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HAMASAKI Shinichi

    Kindai University Nara Hospital　Lecturer in Medical School
Last Updated :2024/04/25

Researcher Information

J-Global ID

Research Areas

  • Life sciences / Anesthesiology

Association Memberships

  • JAPAN SOCIETY OF PAIN CLINICIANS   THE JAPANESE PHARMACOLOGICAL SOCIETY   THE JAPANESE SOCIETY OF INTENSIVE CARE MEDICINE   JAPANESE SOCIETY OF ANESTHESIOLOGISTS   

Published Papers

  • Atsuhiro Kitaura; Hiroatsu Sakamoto; Shinichi Hamasaki; Shota Tsukimoto; Yasufumi Nakajima
    Medicina (Kaunas, Lithuania) 59 (12) 2023/12 
    Background and Objectives: Remimazolam is a new ultrashort-acting benzodiazepine anesthetic. Remimazolam appears to be useful in patients with severe valvular disease because of its minimal cardiovascular impact. In this retrospective case series study, we assessed the efficacy and safety of remimazolam for maintaining hemodynamic stability during anesthetic induction and maintenance. Cases: MitraClip was performed on 18 cases with severe mitral regurgitation with low left ventricular function who presented with heart failure, and remimazolam was administered for general anesthesia with induction (12 mg/kg/h) and maintenance (1 mg/kg/h). The impact of remimazolam on the hemodynamics at anesthetic induction and during anesthetic maintenance was investigated retrospectively using electronic medical records. Blood pressure decreased significantly during anesthetic induction with remimazolam (78.5 [72, 81.25] and 66.1 [62.2, 74.2], median [IQR], p = 0.0001), but only mildly, by about 10 mmHg. There was no significant change in the cardiac index (2.0 [1.8, 2.4] vs. 1.9 [1.8, 2.3], p = 0.57642) or pulse rate (73.5 ± 8.85 vs. 74.7 ± 11.7, mean ± SD, p = 0.0876) during anesthetic induction with remimazolam. All patients underwent MitraClip without major hemodynamic concerns, with no or small increases in inotropes. Conclusions: Remimazolam may be used safely in patients with severe mitral regurgitation and low left ventricular function presenting with heart failure.
  • Atsuhiro Kitaura; Shota Tsukimoto; Hiroatsu Sakamoto; Shinichi Hamasaki; Shinichi Nakao; Yasufumi Nakajima
    Scientific reports 13 (1) 17074 - 17074 2023/10 
    Remimazolam, an ultrashort-acting benzodiazepine, allows for rapid and reliable arousal. Rapid awakening using remimazolam may be beneficial in transcatheter aortic valve replacement (TAVR), as it allows rapid detection of neurologic deficits. The purpose of this study was to compare arousal time and outcomes between monitored anesthesia care (MAC) with remimazolam and remifentanil and conventional MAC with dexmedetomidine, propofol, and remifentanil. This study was a single center retrospective study. All TAVR cases performed under MAC (MAC-TAVR) at our institution between 2019 and 2021 were included. Patients were classified by anesthesia method into remimazolam and dexmedetomidine groups. Among 258 MAC-TAVR patients, 253 were enrolled. After propensity score matching, 76 patients were assigned to each group. The time from end of drug-administration to arousal [20.0 (16.0, 24.0) min vs. 38.5 (30.0, 56.3) min, p < 0.0001] and the time from attempted-arousal to arousal [1.0 (1.0, 1.0) min vs. 12.5 (3.0, 26.8) min, p < 0.0001] were significantly shorter in the remimazolam group. There was no significant difference in the length of ICU stay [2.0 (2.0, 2.0) days vs. 2.0 (2.0, 2.0) days, p = 0.157] and postoperative hospital stay [6.0 (4.0, 9.0) days vs. 5.0 (4.0, 8.0) days, p = 0.262].Trial registration: Clinical trial number: R03-123, Registry URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051635 Registration number: UMIN000045195, Principal investigator's name: Atsuhiro Kitaura, Date of registration: 20 August 2021.
  • Atsuhiro Kitaura; Tatsushige Iwamoto; Shinichi Hamasaki; Shota Tsukimoto; Yasufumi Nakajima
    Cureus 15 (8) e44003  2023/08 [Refereed]
     
    Andexanet alfa is an analog of activated factor X and is used as an antagonist of anti-activated factor X agents. Andexanet alfa is useful for hemostasis in emergent bleeding during direct oral anticoagulant administration, which contributes to safety. In patients undergoing surgery with cardiopulmonary bypass because of heparin resistance, anesthesiologists are faced with a choice of anticoagulants. Herein, we experienced anesthesia for vascular prostheses with cardiopulmonary bypass for acute aortic dissection in a patient who had received andexanet alfa preoperatively. Heparin was initially used as the anticoagulant during cardiopulmonary bypass; however, despite the administration of large doses and antithrombin III preparations, anticoagulation was insufficient. Therefore, nafamostat mesilate was administered and sufficient anticoagulation was attained. The patient completed surgery under cardiopulmonary bypass, coagulation function was recovered shortly after withdrawal, and no obvious adverse effects were observed.
  • Atsuhiro Kitaura; Shinichi Hamasaki; Hiroatsu Sakamoto; Shota Tsukimoto; Yasufumi Nakajima
    Cureus Springer Science and Business Media LLC 15 (7) 2168-8184 2023/07 [Refereed]
  • Atsuhiro Kitaura; Rina Yamamoto; Shota Tsukimoto; Shinichi Hamasaki; Yasuhumi Nakajima
    Cureus 15 (4) e37436  2023/04 
    A small percentage of cases of dermatomyositis are positive for anti-mitochondrial antibodies (AMA), a known marker for primary biliary cirrhosis. AMA-positive myositis is a rare disease that has been reported to be accompanied by myocarditis, resulting in low left ventricular function, supraventricular arrhythmias, and abnormalities of the conduction system. We present a case of AMA-positive myocarditis resulting in sinus arrest during general anesthesia. A 66-year-old female with AMA-positive myocarditis underwent artificial femoral head replacement for osteonecrosis of the femoral head under general anesthesia. During general anesthesia, a nine-second sinus arrest occurred without any inducement. The sinus arrest was thought to be influenced by not only over-suppression caused by severe supraventricular tachycardia derived from sick sinus syndrome but sympathetic depression caused by general anesthesia. Because of the potential for life-threatening cardiovascular events during anesthesia in patients with AMA-positive myositis, it was considered essential to provide adequate preoperative management and intraoperative monitoring during anesthesia for patients with this disease. Herein, we report our case with a literature review.
  • Atsuhiro Kitaura; Takashi Nishinaka; Shinichi Hamasaki; Omer Faruk Hatipoglu; Hidenori Wake; Masahiro Nishibori; Shuji Mori; Shinichi Nakao; Hideo Takahashi
    PLOS ONE Public Library of Science (PLoS) 16 (1) e0245957 - e0245957 2021/01 [Refereed]
     
    Hyperglycaemia provides a suitable environment for infections and the mechanisms of glucose toxicity include the formation of advanced glycation end-products (AGEs), which comprise non-enzymatically glycosylated proteins, lipids, and nucleic acid amino groups. Among AGE-associated phenotypes, glycolaldehyde-derived toxic AGE (AGE-3) is involved in the pathogenesis of diabetic complications. Internalisation of endotoxin by various cell types contributes to innate immune responses against bacterial infection. An endotoxin derived from Gram-negative bacteria, lipopolysaccharide (LPS), was reported to enhance its own uptake by RAW264.7 mouse macrophage-like cells, and an LPS binding protein, CD14, was involved in the LPS uptake. The LPS uptake induced the activation of RAW264.7 leading to the production of chemokine CXC motif ligand (CXCL) 10, which promotes T helper cell type 1 responses. Previously, we reported that AGE-3 was internalised into RAW264.7 cells through scavenger receptor-1 Class A. We hypothesized that AGEs uptake interrupt LPS uptake and impair innate immune response to LPS in RAW264.7 cells. In the present study, we found that AGE-3 attenuated CD14 expression, LPS uptake, and CXCL10 production, which was concentration-dependent, whereas LPS did not affect AGE uptake. AGEs were reported to stimulate the receptor for AGEs and Toll-like receptor 4, which cause inflammatory reactions. We found that inhibitors for RAGE, but not Toll-like receptor 4, restored the AGE-induced suppression of CD14 expression, LPS uptake, and CXCL10 production. These results indicate that the receptor for the AGE-initiated pathway partially impairs the immune response in diabetes patients.
  • Mayuka Matsushima; Seishi Kimura; Atsuhiro Kitaura; Shinichi Hamasaki; Tatsushige Iwamoto; Takashi Mino; Kenichi Masui; Shinichi Nakao
    Journal of clinical pharmacy and therapeutics 46 (2) 433 - 439 2020/10 [Refereed]
     
    WHAT IS KNOWN AND OBJECTIVE: Propofol is the most commonly used intravenous anaesthetic worldwide and is considered to be safe for all ages. However, there have been some reports that propofol induces severe atrioventricular (AV) blocks in humans and some studies demonstrated that propofol suppressed the cardiac conduction system in animals. A precise mechanism by which the block is induced has not been elucidated yet in humans. The objective of this study was to investigate the effects of propofol on the cardiac conduction system and the cardiac autonomic nervous balance in children. METHODS: We enrolled 23 paediatric patients (age: 6-15 years; males: 16, females: 7) who were scheduled to undergo radiofrequency catheter ablation (RFCA) under general anaesthesia. Anaesthesia was induced with 2 mg/kg propofol and 0.5 µg/kg/min remifentanil, and tracheal intubation was performed with the aid of 1 mg/kg rocuronium. Anaesthesia was maintained with 5-7 mg/kg/h propofol and 0.2 µg/kg/min remifentanil during the RFCA. After the completion of the RFCA, anaesthesia was further maintained with 5 mg/kg/h propofol and 0.2 µg/kg/min remifentanil for at least 10 min (LC: low propofol concentration state), followed by the injection of 2 mg/kg propofol and the infusion of 10 mg/kg/h propofol for 10 min (HC: high propofol concentration state). The sinus node recovery time (SNRT), sinoatrial conduction time (SACT), atrial-His (AH) interval and the His-ventricular (HV) interval were measured at the end of both the LC and HC. Cardiac autonomic regulation was simultaneously assessed based on heart rate variability. RESULTS AND DISCUSSION: Propofol significantly suppressed intrinsic cardiac HV conduction, but did not affect the SNRT, SACT or the AH interval. As HV blocks, which occur below the His bundle, are often life-threatening, the HV conduction delay may be a cause of severe AV blocks induced by propofol. Propofol directly suppressed parasympathetic nerve activity, and sympathetic nerve activity was also suppressed. WHAT IS NEW AND CONCLUSION: These results indicate that propofol suppresses the HV conduction and might help to elucidate the mechanism by which propofol causes lethal AV blocks.
  • Perioperative management of coagulopathy in a patient with severe hemophilia B who underwent open abdominal surgery
    Nakao Shinichi
    Masui 68 (1) 80 - 83 2019 [Refereed]
  • Shinichi Hamasaki; Takuro Kobori; Yui Yamazaki; Atsuhiro Kitaura; Atsuko Niwa; Takashi Nishinaka; Masahiro Nishibori; Shuji Mori; Shinichi Nakao; Hideo Takahashi
    Scientific Reports Nature Publishing Group 8 (1) 5901  2045-2322 2018/12 [Refereed]
     
    Advanced glycation end-products (AGEs), which comprise non-enzymatically glycosylated proteins, lipids, and nucleic acid amino groups, play an important role in several diseases and aging processes including angiopathy, renal failure, diabetic complications, and neurodegenerative diseases. Among AGE-associated phenotypes, toxic AGEs, glyceraldehyde-derived AGE-2, and glycolaldehyde-derived AGE-3 are involved in the pathogenesis of diabetic complications. In addition, macrophages are reported to remove extracellular AGEs from tissues via scavenger receptors, leading to the progression of atherosclerosis. In the present study, we found that AGE-2 and AGE-3 enhanced their own endocytic uptake by RAW264.7 mouse macrophage-like cells in a concentration-dependent manner. Furthermore, we demonstrated, for the first time, the morphology of phagocytic macrophages and the endocytosis of AGE particles. The toxic AGEs induced the expression of a scavenger receptor, CD204/scavenger receptors-1 class A (SR-A). Notably, an antibody against CD204 significantly prevented toxic AGE uptake. Moreover, an SR-A antagonistic ligand, fucoidan, also attenuated the AGE-2- and AGE-3-evoked uptake in a concentration-dependent manner. These results indicated that SR-A stimulation, at least in part, plays a role in AGE uptake.
  • Takuro Kobori; Shinichi Hamasaki; Atsuhiro Kitaura; Yui Yamazaki; Takashi Nishinaka; Atsuko Niwa; Shinichi Nakao; Hidenori Wake; Shuji Mori; Tadashi Yoshino; Masahiro Nishibori; Hideo Takahashi
    Frontiers in Immunology Frontiers Media S.A. 9 334  1664-3224 2018/03 [Refereed]
     
    M2 macrophage (Mψ) promotes pathologic angiogenesis through a release of pro-angiogenic mediators or the direct cell-cell interaction with endothelium in the micromilieu of several chronic inflammatory diseases, including rheumatoid arthritis and cancer, where interleukin (IL)-18 also contributes to excessive angiogenesis. However, the detailed mechanism remains unclear. The aim of this study is to investigate the mechanism by which M2 Mψs in the micromilieu containing IL-18 induce excessive angiogenesis in the in vitro experimental model using mouse Mψ-like cell line, RAW264.7 cells, and mouse endothelial cell line, b. End5 cells. We discovered that IL-18 acts synergistically with IL-10 to amplify the production of Mψ-derived mediators like osteopontin (OPN) and thrombin, yielding thrombin-cleaved form of OPN generation, which acts through integrins α4/α9, thereby augmenting M2 polarization of Mψ with characteristics of increasing surface CD163 expression in association with morphological alteration. Furthermore, the results of visualizing temporal behavior and morphological alteration of Mψs during angiogenesis demonstrated that M2-like Mψs induced excessive angiogenesis through the direct cell-cell interaction with endothelial cells, possibly mediated by CD163.
  • Houri K; S Hamasaki; Tsujimoto T; Uchida T; Iwamoto T; Shirai T; Nakao S
    JA clinical reports Springer Science and Business Media LLC 4 (1) 6  2018 [Refereed]
  • Seishi Kimura; Shinichi Nakao; Atsuhiro Kitaura; Tatushige Iwamoto; Kei Houri; Mayuka Matsushima; Shinichi Hamasaki
    PLOS ONE PUBLIC LIBRARY SCIENCE 12 (12) e0188555  1932-6203 2017/12 [Refereed]
     
    QTc interval prolongation is a serious diabetic complication and increases mortality rate. Hyperglycemia inhibits the rapid component of delayed rectifier potassium channel currents (Ikr) and prolongs the QTc interval on electrocardiograms. Sevoflurane also inhibits the Ikr and causes QTc interval prolongation. In fact, torsade de pointes occurred in a patient with poorly controlled diabetes mellitus during sevoflurane anesthesia. We enrolled 74 patients, including 37 normoglycemic patients (glycated hemoglobin [HbA1c]: <6.5%) (NG group) and 37 chronically hyperglycemic patients (HbA1c: >= 6.5%) (HG group). Anesthesia was induced with 2 mg/kg propofol and 0.3 mu g/kg/min remifentanil, and maintained with 2% sevoflurane in 40% O-2 and 0.2-0.3 mu g/kg/min remifentanil. The QT interval and Tp-e interval (from the peak to the end of the T wave) were measured before and at 5, 10, 30, 60, 90, and 120 min after the administration of sevoflurane and adjusted for the patient's heart rate (QTc and Tp-ec, respectively). P-values of <0.05 were considered statistically significant. The QTc and the Tp-ec intervals of the two groups did not differ significantly before the administration of sevoflurane. The QTc interval gradually increased with time in both groups and was significantly longer than the baseline value at 10 min after the administration of sevoflurane in both groups. The QTc interval of the HG group was significantly longer than that of the NG group at 90 min and 120 min after the administration of sevoflurane. The Tp-ec interval was not affected by sevoflurane in either group. We have demonstrated that sevoflurane significantly prolongs the QTc interval, and that the extent of the prolongation is significantly greater in chronically hyperglycemic patients than in normoglycemic patients. Although Tp-ec is not affected by sevoflurane, it should be noted that the simultaneous blockade of potassium channels would increase the risk of arrhythmias.
  • Kitaura A; Nakao S; S Hamasaki; Houri K; Tsujimoto T; Kimura S; Matsushima M
    JA clinical reports Springer Science and Business Media LLC 3 (1) 29  2017 [Refereed]
  • Atsuko Niwa; Masahiro Nishibori; Shinichi Hamasaki; Takuro Kobori; Keyue Liu; Hidenori Wake; Shuji Mori; Tadashi Yoshino; Hideo Takahashi
    BRAIN STRUCTURE & FUNCTION SPRINGER HEIDELBERG 221 (3) 1653 - 1666 1863-2653 2016/04 [Refereed]
     
    In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.
  • Atsuhiro Kitaura; Tatsushige Iwamoto; Shinichi Hamasaki; Mayuka Shiba; Yasuhiro Shiokawa; Shinichi Nakao
    Japanese Journal of Anesthesiology Kokuseido Publishing Co. Ltd 65 (2) 157 - 159 0021-4892 2016/02 [Refereed]
     
    A 69-year-old male patient with esophageal cancer underwent video assisted subtotal esophagectomy after neoadjuvant chemotherapy and radiation (50 Gy). Adhesion between esophagus and the aorta was so severe that the aortic arch was damaged and massive bleeding occurred during manipulation of the esophagus. However, as we had expected and prepared for the incident we successfully managed it and emergency thoracic endovascular aortic repair could be performed by cardiac surgeons immediately. Preanesthetic careful consideration and preparation for surgical incidents are necessary for anesthesiologists.
  • 周術期の血糖管理の重要性（誌上抄読会）
    岩元辰篤; 濱崎真一; 辻本宣敏; 北浦淳寛; 法里慧; 高岡敦; 月本翔太; 青木理沙; 中尾慎一
    臨床麻酔 40 1549 - 1553 2016 [Invited]
  • Masaki Fuyuta; Shinichi Nakao; Atsuhiro Kitaura; Tatsushige Iwamoto; Shinichi Hamasaki; Shouhei Iwasaki; Takashi Kurita
    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA W B SAUNDERS CO-ELSEVIER INC 29 (6) 1533 - 1536 1053-0770 2015/12 [Refereed]
     
    Objective: To evaluate the preoperative prevalence of each type of J-wave syndrome electrocardiographic pattern and its association with perioperative cardiac events. Design: Retrospective study. Setting: Single hospital university study. Participants: The study evaluated 930 patients who underwent gynecologic, abdominal, neurosurgical, orthopedic, and urologic surgeries. Interventions: Preoperative standard 12-lead electrocardiogram (ECG) monitoring was performed, and each type of J-wave syndrome ECG pattern types 1, 2, and 3 and Brugada syndrome-type was evaluated. Incidence of perioperative cardiac events was investigated up to 1 year postoperatively using an electronic medical record system. Measurements and Main Results: Data from 789 patients were included in the final study. Of these, 16 patients (2.0%) had J-wave syndrome: 7 patients (0.9%) had type-1 patterns; 5 patients (0.6%) had type-2 patterns; 2 patients (0.3%) had type-3 patterns; and 2 patients (0.3%) had Brugada syndrome-type ECG patterns. A J-point elevation >= 0.2 mV, which is considered to be more dangerous, was found in only 2 patients with Brugada syndrome-type ECG patterns, both of whom suffered perioperative lethal arrhythmias. Conclusion: Patients with J-wave syndrome ECG patterns, even dangerous patterns, are not necessarily associated with a higher risk of perioperative cardiac events. However, Brugada syndrome type ECG patterns should be carefully monitored. (C) 2015 Elsevier Inc. All rights reserved.
  • 妊娠後期に発症した急性腹症手術の麻酔経験
    濱﨑 真一; 柴 麻由佳; 平松 謙二; 中尾 慎一; 髙井 規子
    臨床麻酔 37 (11) 1617 - 1620 2013/11

Conference Activities & Talks

  • Fucoidan, a natural sulfated polysaccharide, attenuates uptake of advanced glycation end-products by macrophages  [Not invited]
    Hamasaki S; Kitaura A; Kobori; Yamazaki; Nishinaka,Niwa; Takahashi H; Nakao S
    31st Annual Congress European Society of Intensive Care Medicine  2018/10
  • 高血糖は何故体に悪いのか？（麻酔科領域講習）  [Not invited]
    濱﨑真一
    日本麻酔科学会第64回関西支部学術集会  2018/09
  • Visualization of advanced glycation end-products phagocytosis by macrophages and identification of possible receptor  [Not invited]
    Hamasaki S; Kobori T; Kitaura A; Yamazaki Y; Nishinaka T; Niwa A; Nakao S; Nishibori M; Takahashi H
    18th World Congress of Basic and Clinical Pharmacology  2018/07
  • Screening of sulfated polysaccharide and sugar-related compounds as the regulator of advanced glycation end-products uptake by macrophage  [Not invited]
    Nishinaka T; Kobori T; Kitaura A; Yamazaki Y; Hamasaki S; Kitaura A; Niwa A; Mori S; Nishibori M; Takahashi H
    18th World Congress of Basic and Clinical Pharmacology  2018/07
  • 分娩後大量出血のためICU管理を行った2例  [Not invited]
    濱﨑 真一; 塩川 泰啓; 岩元 辰篤; 冬田 昌樹; 北浦 淳寛; 法里 慧; 北山 智哉子; 古藤 大和; 中尾 慎一
    第45回日本集中治療医学会学術集会  2018/02
  • Prolonged complete atrioventricular blockinduced by insertion of a pulmonary arterial catheter in a patient with complete left bundle block  [Not invited]
    Kitaura A; Houri K; Hamasaki S; Nakao S
    Annual Meeting of American Society of Anesthesiologists  2017/10
  • インスリン投与後の低カリウム血症により生じた心停止  [Not invited]
    北浦淳寛; 法里 慧; 濱﨑真一; 辻本宜敏; 岩元辰篤; 中尾慎一
    日本心臓血管麻酔学会第22回学術大会  2017/09
  • 肺動脈カテーテル挿入により完全房室ブロックを呈した完全左脚ブロックの1症例  [Not invited]
    法里 慧; 北浦淳寛; 濱﨑真一; 辻本宜敏; 中尾慎一
    日本心臓血管麻酔学会第22回学術大会  2017/09
  • 高血糖・血糖管理（教育講演）  [Not invited]
    濱﨑真一
    第61回日本集中治療医学会近畿地方会  2016/07
  • 終末糖化産物（AGEs）はマクロファージによる血管内皮細胞の管腔形成を促進する  [Not invited]
    濱崎 真一; 小堀 宅郎; 北浦 淳寛; 丹羽 淳子; 高橋 英夫
    第89回日本薬理学会年会  2016/03
  • カテコラミン誘発性多型性心室頻拍患者の麻酔経験  [Not invited]
    濱﨑 真一; 岩元 辰篤; 北浦 淳寛; 法里 慧; 藤田 明子; 中尾 慎一
    第61回日本麻酔科学会関西支部学術集会  2015/09
  • HMGB1によるヒスタミン誘導性免疫応答調節効果  [Not invited]
    濱﨑 真一; 丹羽 淳子; 小堀 宅郎; 西堀 正洋; 髙橋 英夫
    第125回日本薬理学会近畿部会  2014/06
  • ヒスタミンH2受容体刺激によるHMGB1誘導性免疫応答調節効果の基礎的検討  [Not invited]
    濱﨑真一; 丹羽淳子; 上野浩司; 西堀 正洋; 高橋 英夫
    第87回日本薬理学会年会  2014/03
  • 術後2日目に硬膜外カテーテルを抜去後一過性の神経症状を呈した症例の検討  [Not invited]
    北浦 淳寛; 平松 謙二; 濱﨑 真一; 南 奈穂子; 岩元 辰篤; 冬田 昌樹; 中尾 慎一
    日本臨床麻酔学会第33回大会  2013/11  石川県金沢市  日本臨床麻酔学会第33回大会
  • 左肺下葉切除既往患者の右開胸気管形成術の麻酔経験  [Not invited]
    田中 祐子; 梶川 竜治; 濱﨑 真一; 中尾 慎一
    日本臨床麻酔学会第33回大会  2013/11  石川県金沢市  日本臨床麻酔学会第33回大会
  • 妊娠後期の急性腹膜症手術の全身麻酔管理  [Not invited]
    濱崎 真一; 柴 麻由佳; 平松 謙二; 田中 祐子; 梶川 竜治; 中尾 慎一
    日本臨床麻酔学会 第32回大会  2012/11  大阪市  日本麻酔学会・関西支部症例検討会
  • グライドスコープRで挿管困難時にスタイレットを使用して成功した3症例  [Not invited]
    岩元 辰篤; 平松 謙二; 濱﨑 真一; 梶川 竜治; 塩川 泰啓; 中尾 慎一
    日本臨床麻酔学会第32回大会  2012/11  郡山市  日本臨床麻酔学会第32回大会

MISC

Research Grants & Projects

  • 糖尿病を伴う虚血性疾患の細胞障害メカニズム
    科学研究費補助金:若手研究
    Date (from‐to) : 2019/04 -2023/03 
    Author : 濱﨑 真一
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2014/04 -2017/03 
    Author : NIWA Atsuko
     
    Beneficial effects of exercise (EX) in the hypothalamus and bone marrow (BM)were examined for homeostasis and regeneration. A neural progenitor cell, tanycytes, proliferated, differentiated, and matured to NeuN+ neuron in the hypothalamus of adult SHRSP. EX activated tanycytes and promoted cell turn over. Neurogenesis may require FGF-2 and EGF production in adult hypothalamus, and restore physiological and neural functions effectively after stroke in EX SHRSP. Myeloid cell ratio was increased with progression of cerebrovascular disease and that was normalized by EX. Stroke injury induced dynamic fluctuation in SDF-1 distribution that correlated with variations in niche occupation of CD34+/c-kit+ angiogenic stem/progenitor cells. Stem cell niches (SDF-1) in EX responded to injury-related cues that mobilized CD34+ cells from endosteal niche after stroke to sinusoidal vascular niche, which promoted the progenitor proliferation. EX improves the mobilization and activation of BM stem cells.
  • 高血糖を伴う虚血による細胞障害のメカニズム
    大阪難病財団：
    Date (from‐to) : 2016/04 -2017/03 
    Author : 濱﨑 真一
  • 肝切除術臓器障害改善の試み
    日本学術振興会：科学研究費補助金:若手研究(B)
    Date (from‐to) : 2014/04 -2017/03 
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