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SANO Akiko

    Department of Medicine　Lecturer in Medical School
Last Updated :2024/04/19

Researcher Information

Degree

  • Doctor of Medical Science（2020/12 Kindai University）

URL

Research funding number

  • 80335512

ORCID ID

J-Global ID

Research Interests

  • COVID-19   Bronchial thermoplasty   脱顆粒   ホスホリパーゼC   リン脂質代謝   MAPKファミリー   アラキドン酸代謝   薬理学   好酸球   気管支喘息   ホスフォリパーゼA2   

Research Areas

  • Life sciences / Clinical pharmacy
  • Life sciences / Physiology
  • Life sciences / Infectious disease
  • Life sciences / Allergies and connective tissue disease

Academic & Professional Experience

  • 2014/04  Kindai UniversityFaculty of Medicine医学部講師

Published Papers

  • Akiko Sano; Takenori Kozuka; Nanase Watatani; Yuuki Kunita; Yoshiyuki Kawabata; Kyuya Gose; Ken Shirahase; Kazuya Yoshikawa; Ryo Yamazaki; Yusaku Nishikawa; Takashi Omori; Osamu Nishiyama; Takashi Iwanaga; Hiroyuki Sano; Ryuta Haraguchi; Yuji Tohda; Hisako Matsumoto
    Allergology international : official journal of the Japanese Society of Allergology 2023/11 
    BACKGROUND: Obstructive sleep apnea (OSA) is one of the major co-morbidities and aggravating factors of asthma. In OSA-complicated asthma, obesity, visceral fat, and systemic inflammation are associated with its severity, but the role of bronchial hyperresponsiveness (BHR) is unclear. We investigated the involvement of BHR and mediastinal fat width, as a measure of visceral fat, with OSA severity in patients with OSA and asthma-like symptoms. METHODS: Patients with OSA who underwent BHR test and chest computed tomography scan for asthma-like symptoms were retrospectively enrolled. We evaluated the relationship between apnea-hypopnea index (AHI) and PC20 or anterior mediastinal fat width, stratified by the presence or absence of BHR. RESULTS: OSA patients with BHR (n = 29) showed more obstructive airways and frequent low arousal threshold and lower mediastinal fat width, and tended to show fewer AHI than those without BHR (n = 25). In the overall analysis, mediastinal fat width was significantly positively correlated with AHI, which was significant even after adjustment with age and gender. This was especially significant in patients without BHR, while in OSA patients with BHR, there were significant negative associations between apnea index and airflow limitation, and hypopnea index and PC20. CONCLUSIONS: Risk factors for greater AHI differed depending on the presence or absence of BHR in OSA patients with asthma-like symptoms. In the presence of BHR, severity of asthma may determine the severity of concomitant OSA.
  • 西山 理; 藤田 貢; 吉川 和也; 西川 裕作; 大森 隆; 佐野 安希子; 東田 有智; 松本 久子
    日本呼吸器学会誌 (一社)日本呼吸器学会 11 (増刊) 300 - 300 2186-5876 2022/04
  • Haruna Kitazawa; Nobuyuki Hizawa; Yoshihiro Nishimura; Takao Fujisawa; Takashi Iwanaga; Akiko Sano; Hiroyuki Nagase; Hisako Matsumoto; Takahiko Horiguchi; Satoshi Konno; Koichiro Asano
    Respiratory investigation 59 (5) 670 - 674 2021/09 
    The coronavirus disease 2019 (COVID-19) pandemic has had a great influence on medical practice in Japan. In this study, an online questionnaire-based survey was conducted among doctors routinely involved in the treatment of asthma. The questions included in the survey pertained to their thoughts on asthma treatment amidst COVID-19, changes in their clinical approach toward patients with asthma, and the behavioral changes in patients in the pandemic era. The results revealed a significant impact of the pandemic on asthma treatment. Regardless of whether or not they were directly involved in the treatment of patients with COVID-19, the doctors had avoided using nebulizers in outpatient wards/clinics and routine pulmonary function testing. An increase in canceled appointments and inappropriate/non-adherence to treatment among their patients were noticeable. Furthermore, the survey revealed an extensive impact of the pandemic on the doctors engaged in asthma treatment irrespective of the differences in their medical backgrounds.
  • Hiroyuki Nagase; Yoshihiro Nishimura; Hisako Matsumoto; Naoya Sugimoto; Takashi Iwanaga; Akiko Sano; Satoshi Konno; Nobuyuki Hizawa; Koichiro Asano; Takahiko Horiguchi; Akihito Yokoyama
    Respiratory investigation 59 (5) 679 - 682 2021/09 
    There is a concern that persons with underlying respiratory disease may have increased susceptibility to COVID-19 and/or increased severity/mortality if infected. However, information regarding such patients during the first wave of the epidemic is lacking in Japan. We surveyed chest physicians nationwide, and collected anonymous data concerning 1444 patients. Among COVID-19 patients, the prevalence of asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung diseases (ILD) was 3.4%, 4.8%, and 1.5%, respectively. Among COVID-19 patients with these 3 comorbidities, exacerbation of the comorbidity occurred in 12.2%, 18.8%, and 36.4%, respectively, and mortality (6.2% overall) was 4.1%, 13.0%, and 31.8%, respectively. The prevalence of asthma among COVID-19 patients was not higher than that for the general population, and mortality in COVID-19 patients with asthma was not higher than mortality in COVID-19 patients without underlying respiratory disease. COVID-19 patients having COPD or ILD had relatively high mortality, especially for ILD.
  • Osamu Nishiyama; Shigeki Shimizu; Koji Haratani; Kosuke Isomoto; Junko Tanizaki; Hidetoshi Hayashi; Ryo Yamazaki; Takashi Oomori; Yusaku Nishikawa; Akiko Sano; Kazuhiko Nakagawa; Yuji Tohda
    BMC pulmonary medicine 21 (1) 155 - 155 2021/05 
    BACKGROUND: The utility of bronchoscopy for patients with suspected immune checkpoint inhibitor (ICI)-related pneumonitis is currently debatable. The purpose of this study was to examine the findings of bronchoalveolar lavage (BAL) analysis and transbronchial lung biopsy (TBLB) in non-small cell lung cancer (NSCLC) patients with ICI-related pneumonitis, and to elucidate the clinical significance of bronchoscopy for this health condition. PATIENTS AND METHODS: Consecutive NSCLC patients treated with ICIs, diagnosed with ICI-related pneumonitis after undergoing bronchoscopy between October 2015 and March 2019 were retrospectively screened. Findings of BAL fluid analysis and/or TBLB specimen histology were reviewed. RESULTS: Twelve patients underwent bronchoscopy for the diagnosis of ICI-related pneumonitis, ten of whom underwent BAL. An increase in the proportion of lymphocytes higher than 20% was observed in all ten patients. An increase in the proportion of neutrophils (> 10%) and eosinophils (> 10%) was observed in two and one patient, respectively. TBLB specimens were analyzed for eight patients. Major histologic findings included alveolitis in seven (87.5%) and organizing pneumonia (OP) in five (62.5%) patients. Other findings included acute lung injury and fibrosis. All twelve patients demonstrated favorable outcomes. CONCLUSION: A major characteristic of BAL analysis in ICI-related pneumonitis with NSCLC was an increased proportion of lymphocytes. The histologic features of lung tissue included alveolitis and/or OP. Acute lung injury and fibrosis were observed. Although the necessity of bronchoscopy should be determined on a case-by-case basis, it is necessary to assess these parameters when proper differential diagnosis is needed.
  • 西山 理; 藤田 貢; 國田 裕貴; 白波瀬 賢; 御勢 久也; 吉川 和也; 佐伯 翔; 綿谷 奈々瀬; 西川 裕作; 大森 隆; 佐野 安希子; 佐野 博幸; 岩永 賢司; 東田 有智
    日本呼吸器学会誌 (一社)日本呼吸器学会 10 (増刊) 191 - 191 2186-5876 2021/04
  • Akiko Sano; Hiroyuki Sano; Takashi Iwanaga; Yuji Tohda
    European journal of pharmacology 884 173353 - 173353 2020/10 
    Phosphatidylinositol-specific phospholipase C (PI-PLC) and cytosolic phospholipase A2 (cPLA2) regulate both eosinophil degranulation and leukotriene (LT) synthesis via PI-PLC-mediated calcium influx and cPLA2 activation. Phosphatidylcholine-specific phospholipase C (PC-PLC) likely plays a key role in cellular signaling, including the eosinophilic allergic inflammatory response. This study examined the role of PC-PLC in eosinophil LT synthesis and degranulation using tricyclodecan-9-yl-xanthogenate (D609), a PC-specific PLC inhibitor. D609 inhibited N-formyl-met-leu-phe + cytochalasin B (fMLP/B)-induced arachidonic acid (AA) release and leukotriene C4 (LTC4) secretion. However, at concentrations that blocked both AA release and LTC4 secretion, D609 had no significant inhibitory effect on stimulated cPLA2 activity. D609 also partially blocked fMLP/B-induced calcium influx, indicating that inhibition of AA release and LTC4 secretion by D609 is due to inhibition of calcium-mediated cPLA2 translocation to intracellular membranes, not inhibition of cPLA2 activity. In addition, D609 inhibited fMLP/B-stimulated eosinophil peroxidase release, indicating that PC-PLC regulates fMLP/B-induced eosinophil degranulation by increasing the intracellular calcium concentration ([Ca2+]i). Overall, our results showed that PC-PLC is critical for fMLP/B-stimulated eosinophil LT synthesis and degranulation. In addition, degranulation requires calcium influx, while PC-PLC regulates LTC4 synthesis through calcium-mediated cPLA2 activation.
  • Yuji Higashimoto; Morihide Ando; Akiko Sano; Sho Saeki; Yusaku Nishikawa; Kanji Fukuda; Yuji Tohda
    Respiratory investigation 58 (5) 355 - 366 2020/09 
    Pulmonary rehabilitation (PR) is recommended as an effective treatment for patients with chronic obstructive pulmonary disease (COPD). Previous meta-analyses showed that PR improves exercise capacity and health-related quality of life (HRQOL). However, they did not evaluate the effect of PR on the sensation of dyspnea. We searched six databases in May 2019 for randomized controlled trials (RCTs) that examined PR, including supervised lower limb endurance training as a minimal essential component that was continued for 4-12 weeks, in patients with stable COPD, with changes from baseline dyspnea as a primary outcome. Secondary outcomes were changes in exercise capacity, HRQOL, activity of daily life (ADL), physical activity (PA), and adverse events. We calculated the pooled weighted mean difference (MD) using a random effects model. We identified 42 studies with 2150 participants. Compared with the control, PR improved dyspnea, as shown using the British Medical Research Council (MRC) questionnaire (MD, -0.64; 95% CI, -0.99 to -0.30; p = 0.0003), transitional dyspnea index (MD, 1.95; 95% CI, 1.09 to 2.81; p = 0.0001), modified Borg score during exercise (MD, -0.62; 95% CI, -1.10 to -0.14; p = 0.01), and Chronic Respiratory Questionnaire (CRQ) dyspnea score (MD, 0.91; 95% CI, 0.39 to 1.44; p = 0.0007). PR significantly increased exercise capacity measured by the 6 min walking distance time, peak workload, and peak VO2. It improved HRQOL measured by the St. George's Respiratory Questionnaire and CRQ, but not on PA or ADL. These results indicated that PR programs including lower limb endurance training improve dyspnea, HRQOL, and exercise capacity in patients with stable COPD.
  • Yusaku Nishikawa; Osamu Nishiyama; Shigeki Shimizu; Akiko Sano; Yuji Tohda
    Thorax 75 (9) 817 - 818 2020/09
  • Yuji Higashimoto; Akiko Sano; Osamu Nishiyama; Hiroyuki Sano; Takashi Iwanaga; Ryuta Haraguchi; Yasutaka Chiba; Kanji Fukuda; Yuji Tohda
    Allergology international : official journal of the Japanese Society of Allergology 69 (3) 453 - 454 2020/07
  • T. Iwanaga; H. Sano; A. Sano; Y. Tohda
    Nihon Kikan Shokudoka Gakkai Kaiho Japan Broncho-Esophagological Society 71 (2) 156 - 158 0029-0645 2020/04 [Refereed]
  • デバイス別にみた喘息患者の吸入手技の比較検討
    岩永 賢司; 吉川 和也; 御勢 久也; 綿谷 奈々瀬; 西川 裕作; 佐野 安希子; 西山 理; 佐野 博幸; 原口 龍太; 東田 有智
    日本内科学会雑誌 (一社)日本内科学会 109 (Suppl.) 249 - 249 0021-5384 2020/02 [Refereed]
  • 御勢 久也; 西山 理; 佐伯 翔; 西川 裕作; 大森 隆; 佐野 安希子; 清水 重喜; 佐野 博幸; 岩永 賢司; 東田 有智
    気管支学 (NPO)日本呼吸器内視鏡学会 42 (1) 91 - 91 0287-2137 2020/01 [Refereed]
  • 佐野 安希子; 清水 重喜; 西川 裕作; 大森 隆; 西山 理; 岩永 賢司; 原口 龍太; 東田 有智
    肺癌 (NPO)日本肺癌学会 59 (6) 886 - 886 0386-9628 2019/11 [Refereed]
  • 西川 裕作; 西山 理; 佐野 安希子; 岩永 賢司; 原口 龍太; 東田 有智; 清水 重喜
    肺癌 (NPO)日本肺癌学会 59 (6) 886 - 886 0386-9628 2019/11 [Refereed]
  • Kazunori Okahashi; Naoki Oiso; Norito Ishii; Shusuke Uchida; Shigeto Yanagihara; Akiko Sano; Yuji Tohda; Takashi Hashimoto; Daisuke Tsuruta; Akira Kawada
    The Journal of dermatology 46 (4) e140-e142  2019/04
  • Hiroyuki Sano; Katsuyuki Tomita; Akiko Sano; Shou Saeki; Yusaku Nishikawa; Osamu Nishiyama; Takashi Iwanaga; Yuji Tohda
    Allergology international : official journal of the Japanese Society of Allergology 68 (2) 191 - 198 2019/04 
    BACKGROUND: We obtain summary estimates of the accuracy of additional objective tests for the diagnosis of adult asthma using systematic review and meta-analysis of diagnostic test accuracy studies. METHODS: Medline, Embase, and other relevant electronic databases were searched for papers published between January 1989 and December 2016. Studies were included if they evaluated the diagnostic accuracy of objective tests, including airway reversibility (AR), airway hyperresponsiveness (AHR), and fractionated exhaled nitric oxide (FeNO) for the diagnosis of adult asthma in patients with symptoms suggestive of asthma. If papers were assessed appropriate using the adapted QUADAS-2 tool, meta-analysis was conducted using the hierarchical bivariate model. This hierarchical model accounts for both within and between study variability. RESULTS: Sixteen studies reported the performance of the evaluated objective tests at presentation. For diagnosis of adult asthma, overall sensitivity and specificity for AR were 0.39 (95% confidence interval [CI] 0.18 to 0.66) and 0.95 (95% CI 0.86 to 1.00); for AHR, 0.86 (95% CI 0.61 to 1.00) and 0.95 (95% CI 0.77 to 1.00); for FeNO, 0.65 (95% CI 0.53 to 0.77) and 0.83 (95% CI 0.75 to 0.90). Comprehensive comparison of three diagnostic tools for adult asthma using the back-calculated likelihood rate (LR) showed that AR and AHR corresponded to a higher LR+, and AHR gave a lower LR-. CONCLUSIONS: In the current situation of no gold standard for diagnosis of adult asthma, AR and AHR are appropriate for ruling-in the true diagnosis, and AHR is superior for ruling-out a diagnosis. Since each objective test had a specific characteristic, it should be chosen depending on the situation, such as the capacity of the institution and the conditions of patients.
  • 佐野 安希子; 佐野 博幸; 綿谷 奈々瀬; 西山 理; 岩永 賢司; 堀口 高彦; 東田 有智
    日本呼吸器学会誌 (一社)日本呼吸器学会 8 (増刊) 280 - 280 2186-5876 2019/03 [Refereed]
  • 胸腔鏡下肺生検で診断した軽症の多中心性キャッスルマン病の1例
    佐伯 翔; 西山 理; 田中 伴典; 佐野 安希子; 岩永 賢司; 東田 有智
    日本呼吸器学会誌 (一社)日本呼吸器学会 7 (5) 342 - 346 2186-5876 2018/09 
    症例は58歳男性。前医で右鼠径リンパ節腫脹に対して生検を施行されたが診断がつかなかった。その際に胸部異常陰影も指摘されたが、自己判断で放置していた。その後、検診で胸部異常陰影、高ガンマグロブリン血症、脾腫を指摘され当科紹介となり診断のため外科的肺生検を施行した。生検の結果小葉間隔壁および周囲の肺胞隔壁に形質細胞の浸潤を認め、HHV-8染色でも陰性であった。前医のリンパ節生検でもリンパ濾胞周囲に形質細胞が認められ、多中心性キャッスルマン病と診断した。呼吸機能障害を認めず軽症の症例と考えられた。(著者抄録)
  • びまん性肺胞出血にて発症した若年肺血管肉腫の一例
    西川 裕作; 西山 理; 清水 重喜; 綿谷 奈々瀬; 佐野 安希子; 東田 有智
    日本呼吸器学会誌 (一社)日本呼吸器学会 7 (増刊) 341 - 341 2186-5876 2018/03
  • 佐野 安希子; 東田 有智
    喘息・アレルギー (株)メディカルレビュー社 29 (2) 151 - 158 2424-1121 2016/10 
    気管支喘息(以下、喘息)と慢性閉塞性肺疾患(COPD)のコンポーネントを併せもつ、喘息-COPDオーバーラップ症候群(ACOS)は、喘息やCOPD単独と比較して急性増悪の頻度や重症度が高く、予後が悪い。併存する喘息の治療を十分に行うことにより予後が改善することから、喘息あるいはCOPDとしてすでに治療している患者に対してACOSである可能性を見逃さず、適切な治療を行うということが重要である。高齢者では喘息やCOPDとしての単一疾患はむしろ少なく、ACOSが高い比率を占めているため、喘息患者が将来ACOSに移行するリスクを知り、早期に診断し増悪を予防することが求められる。(著者抄録)
  • Akiko Sano; Osamu Nishiyama; Hiroyuki Sano; Koichiro Yoshida; Yuji Tohda
    Kekkaku : [Tuberculosis] 91 (9) 617 - 622 0022-9776 2016/09 
    A 52-year-old woman was referred to our hospital presenting with epigastric pain and weight loss. A contrast- enhanced abdominal computed tomography (CT) scan showed a low-density mass in the body of the pancreas, indicative of a malignancy. Endoscopic ultrasound-guided fine needle aspiration of the pancreatic mass was performed three times and showed no specific findings. A distal pancreatectomy was performed, and a pathological examination revealed epitheli- oid cell granulomas and necrosis. Ziehl-Neelsen staining did not reveal acid-fast bacilli in the pancreatic mass. A diagnosis of tuberculosis or sarcoidosis of the pancreas was con- sidered; however, the patient chose to undergo a follow-up examination without therapeutic intervention because the pancreatic mass had been removed completely and she had recovered well. Four months after the operation, the patient was readmitted to our hospital for insulin therapy for pancreatic diabetes. She presented with a fever and a productive cough, and a chest CT scan showed multiple nodules in both upper lobes. A bronchoscopy was performed and bronchoalveolar lavage fluid cultures for Mycobacterium tuberculosis were positive. The patient received antitubercular quadri-therapy and showed symptomatic and radiologic improvement. At the initial examination, we had been unable to establish the correct diagnosis; however, the detection of pulmonary lesions led to the time-delayed diagnosis of pancreatic tuber- culosis. Owing to its rarity, it is difficult to diagnose pancreatic tuberculosis using clinical symptoms and radiological imaging modalities; thus, pathologic and bacteriologic confirmation is essential. To avoid performing an unnecessary laparotomy in patients with pancreatic tuberculosis, increased vigilance and an accurate diagnostic approach are required.
  • 佐野 安希子; 西山 理; 佐野 博幸; 吉田 耕一郎; 東田 有智
    結核 (一社)日本結核病学会 91 (9) 617 - 622 0022-9776 2016/09 
    52歳、女性。心窩部痛と体重減少を主訴に受診。腹部造影CTにて膵体部に腫瘤を認め、膵臓の悪性腫瘍が疑われた。EUS-FNAを3回施行したが診断に至らず、膵体尾部切除術を施行、病理組織診断にて壊死を伴う類上皮細胞肉芽腫を認めた。Ziehl-Neelsen染色で抗酸菌は証明されず、結核やサルコイドーシスが鑑別として考えられたが、腫瘤は完全に切除され、症状も改善していたため、経過観察となっていた。約4ヵ月後、膵性糖尿病に対してインスリン導入のため入院となった際に湿性咳嗽、発熱が出現。CTで両肺上葉に微細結節の集簇を認めた。気管支鏡検査を施行し、気管支洗浄液培養から結核菌陽性となった。抗結核薬4剤の治療を開始し、症状と画像所見の改善を認めた。初回検査時に診断が得られなかったが、後に肺結核の存在が判明したことにより、膵臓の病変は膵結核であったと考えられた。膵結核は稀な疾患であり、臨床所見や画像から診断することが困難であるため、病理学的、細菌学的確証が重要である。まず結核の可能性を疑って正確な診断アプローチを行うことが必要であり、それによって不要な外科的切除を避けることができる。(著者抄録)
  • Yuji Higashimoto; Toshiyuki Yamagata; Kazushige Maeda; Noritsugu Honda; Akiko Sano; Osamu Nishiyama; Hiroyuki Sano; Takashi Iwanaga; Yasutaka Chiba; Kanji Fukuda; Yuji Tohda
    Geriatrics & gerontology international 16 (8) 934 - 41 2016/08 
    AIM: To evaluate the influence of comorbidities and aging on pulmonary rehabilitation (PR) efficacy in patients with chronic obstructive pulmonary disease (COPD). METHODS: This was a retrospective cohort study of patients with COPD attending an outpatient PR program. Comorbidity information was collected with the Charlson Index, BODE index and COPD-specific comorbidity test, and also included other common conditions not included in these indexes. The efficacy of PR was defined as a 54-m increase in 6-min walk distance or a four-point decrease in St. George's Respiratory Questionnaire score. Patients were divided into two age groups according to the median age of 72 years. RESULTS: A total of 21 of 52 patients (40%) showed a clinically significant benefit by the 6-min walk distance, and 29 patients (55.8%) by the St. George's Respiratory Questionnaire score. PR efficacy was not different between the elderly group and the younger group by either parameter. A total of 98% of the patients had at least one chronic comorbidity. Hypertension was the most frequently reported comorbidity (28.5%). Higher body mass index, Hospital Anxiety and Depression Scale anxiety score and St. George's Respiratory Questionnaire total score were associated with a good response to PR by the 6-min walk distance. None of the individual comorbidities or indexes were correlated with the efficacy of PR. Multiple logistic regression analysis showed that body mass index was independently associated with the response to PR. CONCLUSIONS: PR is equally effective in elderly and younger patients with COPD, with efficacy influenced by body mass index and anxiety. Geriatr Gerontol Int 2016; 16: 934-941.
  • Hiroyuki Sano; Takashi Iwanaga; Osamu Nishiyama; Akiko Sano; Yuji Higashimoto; Katsuyuki Tomita; Yuji Tohda
    Allergology international : official journal of the Japanese Society of Allergology 65 (2) 204 - 209 2016/04 
    BACKGROUND: The characteristics of phenotypes of elderly patients with asthma are unknown. The aim of this study was to classify these phenotypes using lung function tests and images from high-resolution computed tomography (HRCT), and to identify associations between clinical characteristics and phenotypes. METHODS: A cross-sectional study was conducted in 165 elderly patients (>65 years of age) who underwent a multidimensional assessment of clinical and functional status and comorbidity. The patients were divided into three phenotypes: (1) asthma-predominant, (2) asthma-obstructive airway disease (OAD) overlap without emphysema, and (3) asthma-OAD overlap with emphysema (asthma-emphysema overlap) based on chest HRCT. A receiver operating characteristic (ROC) curve was constructed to evaluate the cutoff for differentiating between the two OAD phenotypes. Multivariate analysis was also used to distinguish between these two phenotypes. RESULTS: The phenotypes were asthma-predominant in 48 patients (29%), asthma-OAD without emphysema in 36 (22%), and asthma-emphysema in 81 (49%). Patients with asthma-emphysema were more frequent smokers. In multivariate analysis, smoking status (odds ratio 2.92: 95% CI 1.21-7.00, P = 0.03) and % predicted FEV1 ≤70% (odds ratio 3.18: 95% CI 1.13-8.92, P = 0.03) differed significantly between the asthma-emphysema and asthma-OAD without emphysema phenotypes. CONCLUSIONS: Half of elderly patients with asthma are characterized by asthma-emphysema overlap. Our results showed that elderly patients with asthma who are smokers and have moderate or severe OAD are also likely to have emphysema.
  • Osamu Nishiyama; Ryo Yamazaki; Akiko Sano; Toshiyuki Yamagata; Hiroyuki Sano; Takashi Iwanaga; Yuji Higashimoto; Hiroaki Kume; Yuji Tohda
    Chronic respiratory disease 13 (1) 40 - 7 2016/02 
    Emphysema on high-resolution computed tomography of the chest is the recent focus in the general practice in idiopathic pulmonary fibrosis (IPF). However, adequate attention has not been paid to obstructive disorder. Therefore, we retrospectively evaluated the association between the degree of airway obstruction and longevity in IPF subjects, with a hypothesis that lower forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) has an impact on prognosis. One hundred and fourteen consecutive IPF subjects who had been diagnosed with IPF and had undergone evaluation including pulmonary function test from January 2008 to May 2013 were included in the study. The relationship between baseline data and survival was examined. FEV1/FVC was widely distributed, ranging from 48.6% to 100%. On both univariate and multivariate Cox's regression analyses, lower FEV1/FVC was significantly associated with better survival (hazard ratio of 1.07 and 1.04 and 95% confidential interval of 1.03-1.10 and 1.01-1.08, respectively). Even on analysis with backward selection, FEV1/FVC remained a significant prognostic factor. FEV1/FVC is widely distributed and negatively predicts survival in IPF. A FEV1/FVC should be assessed in "real-world" general practice. Also, the effect of smoking on the clinical course of IPF should be investigated further.
  • Yuji Higashimoto; Noritsugu Honda; Toshiyuki Yamagata; Akiko Sano; Osamu Nishiyama; Hiroyuki Sano; Takashi Iwanaga; Hiroaki Kume; Yasutaka Chiba; Kanji Fukuda; Yuji Tohda
    The European respiratory journal 46 (6) 1615 - 24 2015/12 
    This study was designed to investigate the association of perceived dyspnoea intensity with cortical oxygenation and cortical activation during exercise in patients with chronic obstructive pulmonary disease (COPD) and exertional hypoxaemia.Low-intensity exercise was performed at a constant work rate by patients with COPD and exertional hypoxaemia (n=11) or no hypoxaemia (n=16), and in control participants (n=11). Cortical oxyhaemoglobin (oxy-Hb) and deoxyhaemoglobin (deoxy-Hb) concentrations were measured by multichannel near-infrared spectroscopy. Increased deoxy-Hb is assumed to reflect impaired oxygenation, whereas decreased deoxy-Hb signifies cortical activation.Exercise decreased cortical deoxy-Hb in control and nonhypoxaemic patients. Deoxy-Hb was increased in hypoxaemic patients and oxygen supplementation improved cortical oxygenation. Decreased deoxy-Hb in the pre-motor cortex (PMA) was significantly correlated with exertional dyspnoea in control participants and patients with COPD without hypoxaemia. In contrast, increased cortical deoxy-Hb concentration was correlated with dyspnoea in patients with COPD and hypoxaemia. With the administration of oxygen supplementation, exertional dyspnoea was correlated with decreased deoxy-Hb in the PMA of COPD patients with hypoxaemia.During exercise, cortical oxygenation was impaired in patients with COPD and hypoxaemia compared with control and nonhypoxaemic patients; this difference was ameliorated with oxygen supplementation. Exertional dyspnoea was related to activation of the pre-motor cortex in COPD patients.
  • NISHIYAMA OSAMU; MIYAJIMA HIROYUKI; WATATANI NANASE; OKIMOTO NAMI; FUKAI YUMI; IMBE SHU; TSUKAMOTO KEIZO; SANTO KEISHI; ICHIHASHI HIDEO; MAKINO YASUSHI; SANO AKIKO; SATO RYUJI; YAMAGATA TOSHIYUKI; SANO HIROYUKI; IWANAGA TAKASHI; HIGASHIMOTO YUJI; NAKAJIMA HIROKAZU; TOMITA KATSUYUKI; KUME HIROAKI; TODA YUJI
    日本胸部臨床 72 (5) 545 - 552 0385-3667 2013/05
  • Katsuyuki Tomita; Hiroyuki Sano; Yasutaka Chiba; Ryuji Sato; Akiko Sano; Osamu Nishiyama; Takashi Iwanaga; Yuji Higashimoto; Ryuta Haraguchi; Yuji Tohda
    Primary care respiratory journal : journal of the General Practice Airways Group 22 (1) 51 - 8 2013/03 
    BACKGROUND: To predict the presence of asthma in adult patients with respiratory symptoms, we developed a scoring algorithm using clinical parameters. METHODS: We prospectively analysed 566 adult outpatients who visited Kinki University Hospital for the first time with complaints of nonspecific respiratory symptoms. Asthma was comprehensively diagnosed by specialists using symptoms, signs, and objective tools including bronchodilator reversibility and/or the assessment of bronchial hyperresponsiveness (BHR). Multiple logistic regression analysis was performed to categorise patients and determine the accuracy of diagnosing asthma. RESULTS: A scoring algorithm using the symptom-sign score was developed, based on diurnal variation of symptoms (1 point), recurrent episodes (2 points), medical history of allergic diseases (1 point), and wheeze sound (2 points). A score of >3 had 35% sensitivity and 97% specificity for discriminating between patients with and without asthma and assigned a high probability of having asthma (accuracy 90%). A score of 1 or 2 points assigned intermediate probability (accuracy 68%). After providing additional data of forced expiratory volume in 1 second/forced vital capacity (FEV(1)/FVC) ratio <0.7, the post-test probability of having asthma was increased to 93%. A score of 0 points assigned low probability (accuracy 31%). After providing additional data of positive reversibility, the post-test probability of having asthma was increased to 88%. CONCLUSIONS: This pragmatic diagnostic algorithm is useful for predicting the presence of adult asthma and for determining the appropriate time for consultation with a pulmonologist.
  • S. Yamagata; K. Tomita; H. Sano; Y. Itoh; Y. Fukai; N. Okimoto; N. Watatani; S. Inbe; H. Miyajima; K. Tsukamoto; H. Santoh; H. Ichihashi; A. Sano; R. Sato; Y. Tohda
    Clinical and Experimental Immunology 170 (1) 86 - 93 0009-9104 2012/10 [Refereed]
     
    We investigated the non-genomic effects of glucocorticoids (GCs) on inhibition of plasma membrane lipid raft formation in activated human basophils. Human basophils obtained from house dust mite (HDM)-sensitive volunteers were pretreated with hydrocortisone (CORT) or dexamethasone (Dex) for 30min and then primed with phorbol 12-myristate 13-acetate (PMA, 10 ng/ml) or HDM (10μg/ml). The expression of CD63, a basophil activation marker, was assessed by flow cytometry. Membrane-bound GC receptors (mGCRs) were analysed by flow cytometry and confocal laser microscopy. Lipid rafts were assessed using a GM1 ganglioside probe and visualization by confocal laser microscopy. Pretreatment of basophils with CORT (10-4M and 10-5M) and Dex (10-7M) significantly inhibited CD63 expression 20min after addition of PMA or HDM. The inhibitory effects of GCs were not altered by the nuclear GC receptor (GCR) antagonist RU486 (10-5M) or the protein synthesis inhibitor cycloheximide (10-4M) (P< 0·05). CORT coupled to bovine serum albumin (BSA-CORT) mimicked the rapid inhibitory effects of CORT, suggesting the involvement of mGCRs. mGCRs were detectable on the plasma membrane of resting basophils and formed nanoclusters following treatment with PMA or HDM. Pretreatment of cells with BSA-CORT inhibited the expression of mGCRs and nanoclustering of ganglioside GM1 in lipid rafts. The study provides evidence that non-genomic mechanisms are involved in the rapid inhibitory effect of GCs on the formation of lipid raft nanoclusters, through binding to mGCRs on the plasma membrane of activated basophils. © 2012 British Society for Immunology.
  • Ryuji Sato; Katsuyuki Tomita; Hiroyuki Sano; Hideo Ichihashi; Shigeyoshi Yamagata; Akiko Sano; Toshiyuki Yamagata; Takayuki Miyara; Takashi Iwanaga; Masato Muraki; Yuji Tohda
    The Journal of asthma : official journal of the Association for the Care of Asthma 46 (7) 677 - 82 2009/09 
    BACKGROUND: Various factors have been reported to be useful for predicting future exacerbations. OBJECTIVE: This study was intended to determine a usefulness of a combination of a patient-based questionnaire, such as the Asthma Control Test (ACT) score with objective assessments, such as forced expiratory volume in 1 second (FEV(1)) and/or exhaled nitric oxide (FE(NO)), for predicting future exacerbations in adult asthmatics. METHODS: We therefore enrolled 78 subjects with mild to moderate asthma, who were clinically stable for 3 months who all had been regularly receiving inhaled steroid treatment. All subjects underwent a routine assessment of asthma control including the ACT score, spirometry, and FE(NO), and then were followed up until a severe exacerbation occurred. The predictors of an increased risk of severe exacerbation were identified and validated using decision trees based on a classification and regression tree (CART) analysis. The properties of the developed models were the evaluated with the area under the ROC curve (AUC) (95% confidence interval [CI]). RESULTS: The CART analysis automatically selected the variables and cut-off points, the ACT score
  • 中野 志仁; 山片 重良; 忌部 周; 宮嶋 宏之; 塚本 敬造; 山藤 啓史; 西川 裕作; 内藤 映理; 市橋 秀夫; 池田 容子; 佐野 安希子; 山縣 俊之; 佐藤 隆司; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 冨田 桂公; 東田 有智
    近畿大学医学雑誌 近畿大学医学会 34 (2) 165 - 169 0385-8367 2009/06 
    [抄録]胸水貯留は胸腔内に過剰な液体が貯留する病態であり，胸水の性状より漏出性および滲出性胸水に分類される.胸水貯留の原因疾患に伴い治療方針が異なるため，鑑別が重要となる.今回我々は胸水の貯留を認め，その原因疾患の診断に苦慮した1例を経験したため，鑑別診断を中心に文献的考察を加えて報告する.
  • Norimasa Miura; Yasunobu Kanamori; Masakuni Takahashi; Reina Sato; Tomoe Tsukamoto; Shunsaku Takahashi; Tomomi Harada; Akiko Sano; Kohei Shomori; Tasuku Harada; Junzou Kigawa; Hisao Ito; Naoki Terakawa; Junichi Hasegawa; Goshi Shiota
    Oncology reports 17 (3) 541 - 8 1021-335X 2007/03 
    Human telomerase reverse transcriptase (hTERT) and epidermal growth factor receptor (EGFR) play an important role in many cancers including gynecological cancers. We previously reported the usefulness of a quantitative highly sensitive detection method for hTERT mRNA in the serum of cancer patients. By this method, we attempted to elucidate the diagnostic evaluation of serum hTERT mRNA for gynecologic malignancies. In 174 female patients with gynecological lesions (47 with ovarian lesions, 63 with uterine lesions, 2 with malignancies in other gynecological lesions, and 62 benign lesions) and 20 healthy individuals, we measured serum hTERT mRNA and EGFR mRNA by using the newly developed real-time quantitative RT-PCR. We examined their sensitivity and specificity in cancer diagnosis, clinical significance in comparison with conventional tumor markers, and their correlations with the clinical parameters by using multivariate analyses. Serum hTERT mRNA showed higher values in patients with gynecologic cancers than in those with benign diseases and healthy individuals. The hTERT mRNA level independently correlated with the presence of cancers (P=0.004 for both ovarian and uterine cancer) and clinical stage (P<0.001). The sensitivity and specificity of hTERT mRNA in cancer diagnosis was 74.4% and 74.1%, respectively. The hTERT mRNA level showed a significant correlation with CA125 by Pearson's relative test (P=0.035) and with histological findings in ovarian cancer by the Friedman test (P<0.004). EGFR mRNA did not display any differences between the diseases. hTERT mRNA is useful for diagnosing gynecologic cancer and is superior to conventional tumor markers. Therefore, serum hTERT mRNA is a novel and available biomarker for gynecologic malignancies.
  • Norimasa Miura; Hiroshige Nakamura; Reina Sato; Tomoe Tsukamoto; Tomomi Harada; Shunsaku Takahashi; Youshin Adachi; Kohei Shomori; Akiko Sano; Yosuke Kishimoto; Hisao Ito; Junichi Hasegawa; Goshi Shiota
    Cancer science 97 (12) 1366 - 73 1347-9032 2006/12 
    Using a newly developed assay of telomerase reverse transcriptase (hTERT) mRNA in serum by real-time RT-PCR, we previously reported this assay to be superior to other tumor markers for hepatoma. In this study, we aimed to clarify its clinical significance as a biomarker for lung cancer. In 112 patients with lung tumor and 80 individuals without cancer, we measured serum hTERT mRNA and epidermal growth factor receptor (EGFR) mRNA levels, using a quantitative one-step real-time RT-PCR assay. We examined its sensitivity and specificity in lung cancer diagnosis, its clinical significance in comparison with other tumor markers, and its correlation with the clinical parameters using multivariate analyses and correlation relative tests. The copy number of serum hTERT mRNA was independently correlated with tumor size, tumor number, presence of metastasis and recurrence, and smoking (all P < 0.05). EGFR mRNA correlated with tumor number and clinical stage (both P < 0.05). The sensitivity and specificity in lung cancer diagnosis were 89.0% and 72.7% for hTERT mRNA, and 71.3% and 80.0% for EGFR mRNA, respectively. hTERT mRNA was superior to other tumor markers in lung cancer diagnosis. For both mRNAs, serum levels were significantly correlated with levels in lung cancer tissues (both P < 0.05). The copy number of hTERT mRNA significantly decreased after the surgical treatment. The data suggest that hTERT mRNA, especially when combined with EGFR mRNA, is a novel and excellent biomarker for pulmonary malignancies to diagnose and assess the clinical stage.
  • Akira Marumoto; Junichi Hasegawa; Fang Zhang; Hisato Moritani; Tomomi Harada; Akiko Sano; Norimasa Miura; Yosuke Kishimoto; Shigetsugu Ohgi
    Journal of cardiovascular pharmacology 46 (2) 167 - 76 0160-2446 2005/08 
    We examined the electrophysiological effects of trapidil on the ionic currents influencing the repolarization and on the transient inward current (ITi) that can cause triggered arrhythmia using the whole-cell patch-clamp technique in guinea pig ventricular myocytes. Trapidil shortened the action potential duration (APD) and increased the delayed rectifier potassium current (IK) in a concentration-dependent manner. The effect of trapidil on the rapidly and slowly activating components of IK (IKr and IKs, respectively) was studied by the envelope of tails test. Trapidil failed to affect IKr and selectively enhanced IKs. Trapidil increased the amplitude of the L-type Ca2+ current (ICa,L), with an acceleration of its inactivation, whereas isoproterenol, a beta-adrenoceptor agonist, increased the amplitude of the ICa,L in a different manner. Isoproterenol activated ITi; however, trapidil not only failed to facilitate ITi but also suppressed isoproterenol-induced ITi. The inhibitory effect of trapidil on isoproterenol-induced ITi is at least partly via a reduction of Ca2+ overload through an acceleration of ICa,L inactivation and/or a sarcoplasmic reticulum (SR) Ca channel modulation. These results suggest that trapidil does not prolong the QT interval and has an antiarrhythmic effect on arrhythmias elicited by triggered activity secondary to Ca2+ overload at much higher concentrations than clinical concentration.
  • Norimasa Miura; Yoshiko Maeda; Takamasa Kanbe; Hiroaki Yazama; Yohei Takeda; Reina Sato; Tomoe Tsukamoto; Emi Sato; Akira Marumoto; Tomomi Harada; Akiko Sano; Yosuke Kishimoto; Yasuaki Hirooka; Yoshikazu Murawaki; Junichi Hasegawa; Goshi Shiota
    Clinical cancer research : an official journal of the American Association for Cancer Research 11 (9) 3205 - 9 1078-0432 2005/05 
    PURPOSE: We previously reported the usefulness of a qualified highly sensitive detection method for human telomerase reverse transcriptase (hTERT) mRNA in serum with 89.7% sensitivity for hepatocellular carcinoma (HCC). In this study, we developed a quantitative detection method for serum hTERT mRNA and examined the clinical significance in HCC diagnosis. EXPERIMENTAL BACKGROUND: In 64 patients with HCC, 20 with liver cirrhosis, 20 with chronic hepatitis, and 50 healthy individuals, we measured serum hTERT mRNA by using the newly developed real-time quantitative reverse transcription-PCR with SYBR Green I. We examined its sensitivity and specificity in HCC diagnosis, clinical significance in comparison with other tumor markers, and its correlations with the clinical variables by using multivariate analyses. RESULTS: Serum hTERT mRNA showed higher values in patients with HCC than those with chronic liver diseases. hTERT mRNA expression was shown to be independently correlated with clinical variables such as tumor size, number, and degree of differentiation (P < 0.001, each). The sensitivity/specificity of hTERT mRNA and alpha-fetoprotein (AFP) mRNA in HCC diagnosis were 88.2%/70.0% for hTERT and 71.6%/67.5% for AFP, respectively. hTERT mRNA proved to be superior to AFP mRNA, AFP, and des-gamma-carboxy prothrombin in HCC diagnosis. Furthermore, hTERT mRNA in serum was associated with that in HCC tissue. CONCLUSIONS: The usefulness of hTERT mRNA expression in HCC diagnosis and its superiority to conventional tumor markers were shown. Therefore, serum hTERT mRNA is a novel and available marker for HCC diagnosis.
  • Junichi Hasegawa; Akiko Sano; Norimasa Miura
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica 124 (5) 353 - 7 0015-5691 2004/11
  • Masaki Sudoh; Yosuke Kishimoto; Akira Marumoto; Mikio Inoue; Akiko Sano; Norimasa Miura; Yasushi Horie; Junichi Hasegawa; Kazuo Ryoke
    Life sciences 74 (24) 3025 - 32 0024-3205 2004/04 
    Although superselective continuous intra-arterial infusion has advantages for cancer therapy, intra-arterial chemotherapy is often interrupted by arterial damage due to arteritis. Therefore, an animal model must be developed to elucidate the mechanism of arteritis associated with continuous anti-cancer drug infusion. We developed a new rat model with which to investigate the causal mechanism(s) of vascular damage associated with continuous catheterization chemotherapy. Chemotherapeutic agents (fluorouracil (5-FU) or peplomycin (PEP)) were continuously administered for 7 days into the abdominal aorta of male Sprague-Dawley rats through a catheter fixed in situ. We found that the incidence of apoptotic endothelial cells of the aorta was higher nearer the tip of the catheter. The incidence of apoptosis was higher in the group treated with 5-FU than with PEP. This animal model will be useful to improve arterial damage among patients undergoing chemotherapy using continuous catheterization.

Conference Activities & Talks

  • Ｐrimaryeffusion lymphomaの一例  [Not invited]
    宮嶋 宏之; 佐野 博幸; 忌部 周; 塚本 敬造; 山藤 啓史; 西川 裕作; 山片 重良; 市橋 秀夫; 内藤 映理; 佐野 安希子; 佐藤隆司; 山縣 俊之; 宮良 高維; 岩永 賢司; 村木 正人; 冨田 桂公; 東田 有智
    第72回日本呼吸器学会近畿地方会  2008/12  第72回日本呼吸器学会近畿地方会
  • interleukin-18の上下気道リモデリングへの影響～期間新喘息マウスモデルを用いた検討～  [Not invited]
    山片 重良; 冨田 桂公; 佐藤隆司; 山藤 啓史; 西川 裕作; 内藤 映理; 市橋 秀夫; 池田容子; 佐野 安希子; 山縣 俊之; 佐野 博幸; 岩永 賢司; 村木 正人; 東田 有智
    第58回日本アレルギー学会  2008/11  第58回日本アレルギー学会
  • Interleukin-18欠損マウスにおける慢性気道炎症および気道リモデリングの抑制についての検討  [Not invited]
    山片 重良; 冨田 桂公; 佐藤隆司; 山藤 啓史; 星 晋; 西川 裕作; 内藤 映理; 市橋 秀夫; 池田容子; 佐野 安希子; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 東田 有智
    第18回国際喘息学会日本北アジア部会  2008/07  第18回国際喘息学会日本北アジア部会
  • ヒト好酸球細胞内のｃＰＬＡ2の局在変化に与えるＰＣ－ＰＬＣの影響  [Not invited]
    佐野 安希子
    第20回日本アレルギー学会春季臨床大会  2008/06  第20回日本アレルギー学会春季臨床大会
  • 呼気中NO値は将来の喘息発作を予想できるか？  [Not invited]
    内藤 映理; 冨田 桂公; 西川 裕作; 山片 重良; 市橋 秀夫; 佐野 安希子; 池田 容子; 佐藤 隆司; 宮良 高維; 佐野 博幸; 岩永 賢司; 村木 正人; 東田 有智
    第５７回日本アレルギー学会秋季学術大会  2007/11  横浜  第５７回日本アレルギー学会秋季学術大会
  • 喘息モデルにおけるＣｙｓＬＴ1 receptor antagonistとCysLT1/2 antagonistの気道炎症と気道過敏性に対する影響  [Not invited]
    村木 正人; 西川 裕作; 内藤 映理; 市橋 秀夫; 山片 重良; 池田 容子; 佐野 安希子; 佐藤 隆司; 辻 文生; 佐野 博幸; 宮良 高維; 岩永 賢司; 冨田 桂公; 久保 裕一; 東田 有智
    第５７回日本アレルギー学会秋季学術大会  2007/11  横浜  第５７回日本アレルギー学会秋季学術大会
  • ADVIA Centaur（CLIA法）とＣＡＰシステム（ＦＥＩＡ法）による特異的ＩｇＥ抗体測定の比較検討  [Not invited]
    岩永 賢司; 佐藤 隆司; 西川 裕作; 内藤 映理; 池田 容子; 佐野 安希子; 佐野 博幸; 宮良 高維; 村木 正人; 冨田 桂公; 東田 有智; 久保 裕一
    第５７回日本アレルギー学会秋季学術大会  2007/11  横浜  第５７回日本アレルギー学会秋季学術大会
  • 気管支喘息の病型とInterleukin-8(IL-8)遺伝子プロモーター領域多型についての検討  [Not invited]
    岩永 賢司; 森 富美子; 西川 裕作; 坂本 直哉; 内藤 映理; 市橋 秀夫; 山片 重良; 池田 容子; 佐藤 隆司; 佐野 安希子; 佐野 博幸; 宮良 高維; 村木 正人; 久保 裕一; 東田 有智
    第１９回日本アレルギー学会春臨床大会  2007/06  横浜  第１９回日本アレルギー学会春臨床大会
  • Role of phosphatidylcholine-phospholipasa C(PC-PLC)and cytosolic phospholipase A2(cPLA)in sosinophil functions  [Not invited]
    佐野 安希子; 佐野 博幸; 市橋 秀夫; 山片 重良; 岩永 賢司; 東田 有智
    第４７回日本呼吸器学会学術講演会  2007/05  東京  第４７回日本呼吸器学会学術講演会
  • ロイコトリエン受容体拮抗薬が気管支喘息患者の年間憎悪日数に及ぼす影響  [Not invited]
    佐野 博幸; 市橋 秀夫; 佐野 安希子; 西川 裕作; 内藤 映理; 山片 重良; 池田 容子; 佐藤 隆司; 宮良 高維; 岩永 賢司; 村木 正人; 久保 裕一; 東田 有智
    第４７回日本呼吸器学会学術講演会  2007/05  東京  第４７回日本呼吸器学会学術講演会
  • 当科における重症喘息症例の背景因子についての検討  [Not invited]
    岩永 賢司; 西川 裕作; 坂本 直哉; 内藤 映理; 市橋 秀夫; 山片 重良; 池田 容子; 佐野 安希子; 佐藤 隆司; 佐野 博幸; 宮良 高維; 村木 正人; 久保 裕一; 東田 有智
    第47回日本呼吸器学会学術講演会  2007/05  東京  第47回日本呼吸器学会学術講演会
  • 閉塞性睡眠時無呼吸症候群患者におけるREM睡眠中AHIとnonREM睡眠中AHIの検討  [Not invited]
    村木 正人; 内藤 映理; 市橋 秀夫; 山片 重良; 池田 容子; 佐野 安希子; 佐藤 隆司; 辻 文生; 佐野 博幸; 宮良 高維; 岩永 賢司; 原口 龍太; 久保 裕一; 東田 有智
    第４７回日本呼吸器学会学術講演会  2007/05  東京  第４７回日本呼吸器学会学術講演会
  • キサンチン製剤の投与の違いによる気管平滑筋拡張効果  [Not invited]
    久保 裕一; 坂本 直哉; 西川 裕作; 市橋 秀夫; 山片 重良; 内藤 映理; 佐野 安希子; 池田 容子; 佐藤 隆司; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 東田 有智
    第４７回日本呼吸器学会学術講演会  2007/05  東京  第４７回日本呼吸器学会学術講演会
     
    気管支喘息の治療には、キサンチン製剤は気管支拡張作用ならびに抗炎症作用を有し、優れた薬剤である。今回は気管平滑筋収縮に対して、キサンチン製剤の投与方法の違いによる拡張効果を検討した。
  • BinaxNowレジオネラ尿中抗原検査の検出限界近くで診断されたレジオネラ肺炎の一例  [Not invited]
    池田 容子; 宮良 高維; 内藤 映理; 佐野 安希子; 佐藤 隆司; 佐野 博幸; 岩永 賢司; 村木 正人; 久保 裕一; 東田 有智
    第６８回日本呼吸器学会第９８回日本結核病学会 近畿地方会  2006/12  神戸  第６８回日本呼吸器学会第９８回日本結核病学会 近畿地方会
  • 当科における小児喘息患者の気道過敏性に影響を及ぼす臨床的因子の検討  [Not invited]
    池田 容子; 佐野 博幸; 市橋 秀夫; 山片 重良; 内藤 映理; 北口 佐也子; 佐野 安希子; 佐藤 隆司; 宮良 高維; 岩永 賢司; 村木 正人; 久保 裕一; 東田 有智; 東田 万智
    第５６回日本アレルギー学会秋季大会  2006/11  東京  第５６回日本アレルギー学会秋季大会
  • 銀溶液のアトピー性皮膚炎に及ぼす影響  [Not invited]
    佐野 安希子; 佐野 博幸; 宮良 高維; 市橋 秀夫; 山片 重良; 岩永 賢司; 久保 裕一; 東田 有智; 長谷川順一
    第５６回日本アレルギー学会秋季学術大会  2006/11  東京  第５６回日本アレルギー学会秋季学術大会
  • 気管支喘息患者における総IgE値と肺機能の検討  [Not invited]
    佐野 博幸; 内藤 映理; 市橋 秀夫; 山片 重良; 池田 容子; 佐藤 隆司; 佐野 安希子; 宮良 高維; 岩永 賢司; 村木 正人; 久保 裕一; 東田 有智
    第５６回日本アレルギー学会秋季学術大会  2006/11  東京  第５６回日本アレルギー学会秋季学術大会
  • キサンチン製剤の気道炎症細胞に対する影響  [Not invited]
    久保 裕一; 坂本 直哉; 西川 裕作; 市橋 秀夫; 山片 重良; 内藤 映理; 佐野 安希子; 北口 佐也子; 池田 容子; 佐藤 隆司; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 東田 有智
    第５６回日本アレルギー学会秋季学術大会  2006/11  東京  第５６回日本アレルギー学会秋季学術大会
  • 睡眠時無呼吸症候群におけるAHIの重症度に寄与する因子についての検討  [Not invited]
    内藤 映理; 佐野 博幸; 市橋 秀夫; 山片 重良; 池田 容子; 北口 佐也子; 上田 朋子; 山藤 緑; 佐野 安希子; 辻 文生; 宮良 高維; 岩永 賢司; 村木 正人; 久保 裕一; 東田 有智
    第４６回日本呼吸器学会学術講演会  2006/06  東京  第４６回日本呼吸器学会学術講演会
  • 気管支喘息患者における症状感受性の検討  [Not invited]
    辻 文生; 内藤 映理; 山片 重良; 市橋 秀夫; 池田 容子; 山藤 緑; 北口 佐也子; 佐野 安希子; 佐野 博幸; 岩永 賢司; 村木 正人; 久保 裕一; 東田 有智
    第１８回日本アレルギー学会春季臨床大会  2006/06  東京  第１８回日本アレルギー学会春季臨床大会
  • 安定期気管支喘息患者のPEF経年変化と影響因子の解析  [Not invited]
    佐野 博幸; 市橋 秀夫; 辻 文生; 佐野 安希子; 山片 重良; 内藤 映理; 池田 容子; 北口 佐也子; 山藤 緑; 宮良 高維; 岩永 賢司; 村木 正人; 久保 裕一; 原口 龍太; 東田 有智
    第４６回日本呼吸器学会学術講演会  2006/06  東京  第４６回日本呼吸器学会学術講演会
  • モルモット気道炎症と気道過敏症亢進に対するｔｈｏｐｈｙｌｌｉｎｅ吸入の効果について  [Not invited]
    村木 正人; 市橋 秀夫; 山片 重良; 池田 容子; 北口 佐也子; 山藤 緑; 佐野 安希子; 辻 文生; 佐野 博幸; 宮良 高維; 岩永 賢司; 久保 裕一; 東田 有智
    第４６回日本呼吸器学会学術講演会  2006/06  東京  第４６回日本呼吸器学会学術講演会
  • アセチルコリンによる気管平滑筋収縮に対するテオフィリン薬とβ交感神経刺激薬の上乗せ気管支拡張効果  [Not invited]
    久保 裕一; 山片 重良; 市橋 秀夫; 内藤 映理; 池田 容子; 北口 佐也子; 山藤 緑; 佐野 安希子; 佐野 博幸; 辻 文生; 宮良 高維; 岩永 賢司; 村木 正人; 東田 有智
    第４６回日本呼吸器学会学術講演会  2006/06  東京  第４６回日本呼吸器学会学術講演会
  • 好酸球増多症と気管支喘息で発症し、細気管支肺胞上皮癌と診断し得た一例  [Not invited]
    北口 佐也子; 佐野 博幸; 内藤 映理; 市橋 秀夫; 山片 重良; 池田 容子; 山藤 緑; 佐野 安希子; 辻 文生; 宮良 高維; 岩永 賢司; 村木 正人; 久保 裕一; 東田 有智
    第１８回日本アレルギー学会春季臨床大会  2006/05  東京  第１８回日本アレルギー学会春季臨床大会
  • 気管支喘息と鼻炎との関連  [Not invited]
    久保 裕一; 内藤 映理; 山片重良; 市橋秀夫; 山藤 緑; 池田 容子; 北口 佐也子; 辻 文生; 佐野 安希子; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 東田 有智
    第１８回日本アレルギー学会春季臨床大会  2006/05  東京  第１８回日本アレルギー学会春季臨床大会
  • 胸水および心嚢液貯留をともなったＳｔｉｌｌ病の１例  [Not invited]
    上田 朋子; 宮良 高維; 池田 容子; 山片 重良; 市橋 秀夫; 内藤 映理; 北口 佐也子; 山藤 緑; 佐野 安希子; 辻 文生; 佐野 博幸; 岩永 賢司; 久保 裕一; 東田 有智
    第６６回日本呼吸器学会・第96回日本結核病学会近畿地方会  2005/12  大阪  第６６回日本呼吸器学会・第96回日本結核病学会近畿地方会
  • 気管支平滑筋収縮に対するβ交感神経刺激薬と抗コリン薬の併用効果  [Not invited]
    久保 裕一; 内藤 映理; 山片 重良; 市橋 秀夫; 池田 容子; 北口 佐也子; 上田 朋子; 山藤 緑; 佐野 安希子; 辻 文生; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 東田 有智
    第57回日本気管食道科学会総会  2005/11  京都  第57回日本気管食道科学会総会
  • 当科におけるＧＥＲＤ合併の気管支喘息患者の検討  [Not invited]
    辻 文生; 市橋 秀夫; 池田 容子; 上田 朋子; 山藤 緑; 佐野 安希子; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 原口 龍太; 久保 裕一; 東田 有智
    第55回日本アレルギー学会秋季学術大会  2005/10  盛岡  第55回日本アレルギー学会秋季学術大会
  • 好酸球Ｐｈｏｓｐｈａｔｉｄｙｌｃｈｏｌｉｎｅーｓｐｅｃｉｆｉｃ ｐｈｏｓｐｈｏｌｉｐａｓｅ Ｃ発現とアラキドン酸代謝調節機構への関与  [Not invited]
    佐野 安希子; 佐野 博幸; 市橋 秀夫; 池田 容子; 山藤 緑; 北口 佐也子; 辻 文生; 東田 有智
    第55回日本アレルギー学会秋季学術大会  2005/10  盛岡  第55回日本アレルギー学会秋季学術大会
  • 好酸球脱顆粒におけるPI-PLCおよびPC-PLC関与と細胞内Ca++調節の比較検討  [Not invited]
    佐野 博幸; 佐野 安希子; 辻 文生; 市橋 秀夫; 宮良 高維; 岩永 賢司; 久保 裕一; 東田 有智
    第５５回日本アレルギー学会秋季学術大会  2005/10  盛岡  第５５回日本アレルギー学会秋季学術大会
  • 吸入指導の再教育期間  [Not invited]
    久保 裕一; 市橋秀夫; 山片重良; 池田 容子; 北口 佐也子; 山藤 緑; 上田 朋子; 佐野 安希子; 辻 文生; 佐野 博幸; 宮良 高維; 岩永 賢司; 村木 正人; 東田 有智; 中島重徳
    第５５回日本アレルギー学会秋季学術大会  2005/10  盛岡  第５５回日本アレルギー学会秋季学術大会

MISC

Research Grants & Projects

  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2025/03 
    Author : 松本 久子; 田辺 直也; 佐藤 晋; 西山 理; 佐野 安希子
     
    令和5年度は、喘息例での胸部CT所見（気管支拡張・細気管支炎像の有無，進展度）等と遺伝子多型との関係を中心に解析した。候補遺伝子としてびまん性汎細気管支炎や非若齢発症喘息のリスク遺伝子であり、分泌型ムチンをコードするHCG22遺伝子の一塩基多型（SNP）rs2523870に着目した。喘息106例において、rs2523870のgenotypeはTT 37名、CT 45名、CC 24名であった。リスクアレルのホモ接合体であるCC型と他との２群比較で、喘息発症年齢、呼吸機能、mReiff score(気管支拡張像の進展度)との関係はなかったが、CC型で好酸球性副鼻腔炎併存率、過去の血液好酸球数、過去の吸入ステロイド量、過去及び直近の胸部CTで細気管支炎罹患葉数が有意に多かった。IL4RA rs8832、IL13 rs20541についても解析を行ったが、mReiff scoreや細気管支炎の罹患葉数との関連は認めなかった。本研究でCC型での細気管支病変が、好酸球性か否かは確認できなかったが、好酸球性副鼻腔炎の併存率から推察すると一定の割合で好酸球性細気管支炎も存在すると考えられる。喘息の細気管支病変例で、好中球性気道炎症を呈するびまん性汎細気管支炎と同様のリスク多型が確認されたことは、分泌型ムチンの異常、気道クリアランスの障害が、炎症型を問わず細気管支病変の形成に寄与する可能性が推察される（J Allergy Clin Immunol 2023 Epub ahead of print）。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2004 -2006 
    Author : HASEGAWA Junichi; MIURA Norimasa; HARADA Tomomi
     
    1) The acute effects of Shinbuto, a Kampo medicine on the contraction activity of guinea-pig cardiac myocytes were studied using a motion analyzer. Shinbuto (3-5 mg/ml) tended to increase the contractile amplitude of myocytes by 56-369% in a concentration dependent manner. However, results obtained under different conditions were inconsistent. 2) The effect of long-term Shinbuto administration on heart and renal genes expression in mice. About 50 genes in the heart and about 100 genes expressed in the kidney showed marked changes. One apoptosis-related gene showed increased expression in the heart, but a decrease in the kidney. 3) The effect of long-term Shinbuto administration to diseased animals was examined in hypertensive heart failure model rats, spontaneously hypertensive rats (SHR). Although control animals (SHR) did not show any symptoms of heart failure nor an increase in natriuretic peptide, each of two of the five ingredients of Shinbuto individually tended to suppress the blood pressure in SHR, while the other three did not show any effect on blood pressure. Each ingredient of Shinbuto changed the expressions of genes related to heat shock protein, renin-angiotensin system, potassium ion and calcium ion channels. These genes seem to be related to hypertension. Gene expressions changed markedly following Shinbuto administration to normal mice, but did not show any remarkable change in these diseased rats. These findings suggest that the effects of Shinbuto, a Kampo medicine vary not only with species, but also with pathological conditions.
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2003 -2005 
    Author : 佐野 安希子
     
    ヒト好酸球におけるPC-PLC(ホスファチジルコリン特異的ホスホリパーゼC)の細胞内Ca^<2+>濃度変化に及ぼす影響と脱顆粒における役割をPI-PLC(ホスファチジルイノシトール特異的ホスホリパーゼC)と比較して検討した。比較するにあたって、PC-PLC特異的阻害剤であるD609とPI-PLC特異的阻害剤であるET-18-OCH_3を用いた。 1.PI-PLC、PC-PLC阻害剤はともにfMLP刺激によるEPO (Eosinophil peroxidase)放出を抑制した。 2.Amplex redを用いたPC-PLC activity assayにおいてPC-PLC阻害剤はPC-PLCの活性化を抑制したが、PI-PLC阻害剤はPC-PLC活性に影響を与えなかった。 また、PI-PLC阻害剤はIP_3産生を抑制したが、PC-PLC阻害剤はIP_3 (inositol triphosphate)産生に影響を与えなかった。 3.PI-PLC阻害剤は細胞内Ca^<2+>濃度上昇を抑制したが、PC-PLC阻害剤は影響を与えなかった。 4.PKC (Protein kinase C)阻害剤はfMLP刺激によるEPO放出を抑制した。 以上の結果より、PI-PLCはPKC活性化とCa^<2+>influxをダウンレギュレートすることによってヒト好酸球の脱顆粒を抑制している。一方、それとは対照的にPC-PLCは細胞内カルシウム濃度の変化に非依存的に脱顆粒を制御していると考えられた。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2002 -2004 
    Author : SANO Hiroyuki; YAMASAKI Akira; SANO Akiko
     
    Cytosolic phospholipase A_2 (PLA_2) is the rate-limiting enzyme involved in the conversion of membrane phospholipids to arachidonic acid (AA) and lysophospholipids, which are readily metabolized to inflammatory mediators such as leukotrienes, thromboxane and platelet-activation factor. It has been recognized that receptor antagonists of leukotrienes or thronboxane are effective for treatment of bronchial asthma. To inhibit cPLA2 thus might be more effective than using leukotrienes or thronboxane receptor antagonist on treatment of bronchial asthma. We previously reported that cPLA2 regulates adhesion of human eosinophils to ICAM-1 or VCAM-1, and that inhibition of cPLA2 blocked eosinophil migration to lung tissue and antigen-induced airway hyperresponsiveness. In this study we investigated whether activity and quantitatition of cPLA2 in eosinophils from patients with asthma is more excessive than its from healthy donors. Both AA release and cPLA2 activity from patients with asthma by 1□M FMLP were greater than its from healthy donors significantly. Quantitation of cPLA2 is 0.36±0.13 ng/10^6 cells from healthy donors and 0.52±0.17 ng/10^6 cells from patients with asthma(p=0.0285)

Others

  • 2022/04 -2023/03  COVID-19重症化における好酸球の役割 
    近畿大学学内研究助成金 研究種目：奨励研究助成金 課題番号：SR07 研究内容：COVID-19における好酸球の免疫調整作用

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