SAWABE Akiyoshi

Researcher Information

Degree

• Doctor of Engineering（Kinki University）

URL

http://www.kindai.ac.jp/agriculture/research-and-education/teachers/introduce/akiyoshi-sawabe-60d.html

Research funding number

• 70257989

J-Global ID

• 200901014201276933

Research Interests

• 食品添加物   生物活性物質   化粧品   食品   植物   バイオアッセイ   メタローム   環境ストレス   香料   分析   分離   ファイトレメディエーション   環境浄化   重金属   Phytoremediation   Food additives   Bioactive compounds   Cosmetic   Food   Plants   Bioassay   Perfume   Environmental purification   Analysis   Isolation   Heavy metal   

Research Areas

• Life sciences / Bioorganic chemistry
• Life sciences / Structural biochemistry
• Nanotechnology/Materials / Biochemistry
• Nanotechnology/Materials / Molecular biochemistry
• Environmental science/Agricultural science / Environmental materials/recycling technology
• Environmental science/Agricultural science / Environmental load reduction/restoration technology

Academic & Professional Experience

• 2007 - 2011  National Institute for Environmental Studies客員研究員（兼任）
• 1999 - 2000  近畿大学農学総合研究所 助教授
• 1999 - 2000  Institute for Comprehensive Agricultural Sciences,
• 1996 - 1999  近畿大学農学総合研究所 講師
• 1996 - 1999  Institute for Comprehensive Agricultural Sciences,
• 1993 - 1996  近畿大学農学総合研究所 助手
• 1993 - 1996  Institute for Comprehensive Agricultural Sciences,
• 1991 - 1993  米国マサチューセッツ工科大学 博士研究員
• 1991 - 1993  Massachusetts Institute of Technology
• Kinki University

Education

•        - 1991  Kindai University  大学院 工学研究科  応用化学
•        - 1991  Kinki University  Graduate School, Division of Engineering
•        - 1985  Kindai University  Faculty of Science and Engineering  応用化学
•        - 1985  Kinki University  Faculty of Science and Engineering

Association Memberships

• JAPANESE SOCIETY FOR ENOLOGY AND VITICULTURE   日本環境化学会   日本土壌肥料学会   日本分析化学会   日本応用きのこ学会   日本油化学会   有機合成化学協会   日本質量分析学会   アメリカ化学会   日本農芸化学会   日本化学会   American Chemical Society   

Published Papers

• Effects of Astaxanthin, Lutein, and Zeaxanthin on Eye-hand Coordination and Smooth-pursuit Eye Movement after Visual Display Terminal Operation in Healthy: A Randomized, Double-blind Placebo-controlled Intergroup Trial

  Akiyoshi Sawabe

  Nutrients 15 1459  2023/03 [Refereed]
  
• Examination of the Effects of a Food Containing NMN (Nicotinamide Mononucleotide) on Skin Function and Safety － A Double-blind Randomized Controlled Trial of 8-week Treatment －

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. 51 (1) 75 - 87 2023/01 [Refereed]
  
• Skin-beautifying effects of Magnolol and Honokiol glycosides

  Akiyoshi Sawabe

  Processes 10 1241  2022/06 [Refereed]
  
• Development of Evaluation Methods for Anti-Glycation Activity and Functional Ingredients Contained in Coriander and Fennel Seeds

  Akiyoshi Sawabe

  Processes 10 982  2022/05 [Refereed]
  
• Sleep improvement effect of Kwanso-deriverd Hypnocallis® -Ⅱ ―A Randomized, Double—blind, Placebo—controlled, Crossover Study―

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. 50 (3) 461 - 467 2022/03 [Refereed]
  
• Sleep Improvement Effect of Kwanso-deriverd Hypnocallis. - I. -Sleep Improvement Effect with the OSA Sleep Questionnaire-

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. 50 (2) 267 - 273 2022/02 [Refereed]
  
• Effects of Shikuwashas (Citrus depressa)-derived Nobiletin and Tangeretin Foods on Eye and Nasal Allergic Reactions. -A Randmized, Placebo-controlled, Double-blind Parallel-group Study-

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. ライフサイエンス出版(株) 50 (2) 257 - 265 0386-3603 2022/02 [Refereed]
   

  シークワーサー由来ノビレチン、タンゲレチン含有食品の摂取による鼻、目のアレルギー反応の軽減効果について検討した。日ごろから鼻や目の不快感のある20歳以上50歳未満の成人健常男女を対象に、摂取期間を8週間としてランダム化プラセボ対照並行群間比較試験を実施した。1カプセルあたりシークワーサー由来のノビレチン19.4mg、タンゲレチン4.15mgを含む粉末を配合したカプセル状の食品を被験食品、シークワーサー粉末の代わりに結晶セルロースへ置き換えた食品をプラセボ食品とした。被験食品群が15名(男性8名、女性7名、平均37.73±6.02歳)、プラセボ食品摂取群が13名(男性7名、女性6名、平均40.00±5.54歳)であった。鼻・目症状スコアにおいては、被験食品群はプラセボ食品群と比較して摂取4週後、摂取8週後の実測値に有意な差が認められ、QOL総スコアにも有意な群間差が認められた。鼻汁中好酸球の程度は摂取期間中ほとんどの被験者で少ない状態が続き、両群間に有意な差は認められなかった。被験食品の安全性に問題はないと考えられた。シークワーサー由来のノビレチン、タンゲレチンを含む食品において、鼻・目の不快な症状の軽減およびQOLの改善が認められた。
• Functional Ingredients and Food Preservative in Immature Persimmon “Tekka-Kaki”

  Akiyoshi Sawabe

  Processes MDPI AG 9 (11) 1989 - 1989 2021/11 [Refereed]
   

  Immature persimmons are unripe fruits that are cut off during the persimmon cultivation process and immediately discarded, amounting to an annual fruit loss of approximately 100 to 400 kg per 1000 m2. The purpose of this study was to make effective use of unused resources, namely, immature persimmons, and attempt to use them as food additives. In this study, we studied the Tone Wase (fully astringent persimmon) and Fuyu (fully sweet persimmon) cultivars. As a result, we performed a component analysis of the immature persimmons, isolating 12 compounds, of which two were newly identified. Differences in the components and their contents were found between cultivars and between the peel and flesh. To effectively use immature persimmons as food for the elderly, we searched for active substances that inhibit AGE formation and found that extracts of immature persimmons and isolated compounds showed high activity. In particular, high activity was observed for catechin and its polymeric form, procyanidin. Regarding the inhibition of aroma deterioration, 5 mg/L of gallic acid in octadecane was found to be the optimal condition for the inhibition of citral deterioration. As for antimicrobial activity, we found that extracts at a concentration of 500 mg/L had no antimicrobial effect. Based on these findings, we made a microencapsulation process, and plan to advance to the clinical trial study in future. These findings confirmed the effectiveness of immature persimmons, which are an unused resource, and reveal their potential as a food for the elderly and as a food additive in other food products, which we hope will lead to new industrial innovations.
• Ingestion of shekwasha juice for the maintenance of body temperature and improvement of blood flow in cold-sensitive individuals —A randomized, double-blind, placebo-controlled, parallel-group study—

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. 49 (2) 313 - 318 2021/02 [Refereed]
  
• Improvement in Quality of Sleep by the Intake of Kwanso-derived oxypinnatanine ―A Randomized, Double—blind, Placebo—controlled, Parallel-group Study―

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. ライフサイエンス出版(株) 48 (7) 1251 - 1258 0386-3603 2020/07 [Refereed]
  
• Investigation of the psychological stress-relieving effects of beverages containing citric acid and Moromi vinegar: -A randomized double-blind placebo-controlled parallel-group study-

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. ライフサイエンス出版(株) 48 (7) 1241 - 1249 0386-3603 2020/07 [Refereed]
  
• Improvement in the Quality of Sleep by the Intake of Saffron-derived Crocin and Safranal: A Randomized, Double-blind, Placebo-controlled, Parallel-group Trial.

  Akiyoshi Sawabe

  Jpn. Pharmacol. Ther. 48 (3) 487 - 504 2020/03 [Refereed]
  
• Actual situation of the weight control in the Japanese functional indication food and food for specified health use

  SAWABE Akiyoshi

  Advances in Obesity Weight Management & Control 8 (2) 57 - 59 2018/04 [Refereed]
  
• Improvement Effect on Human Skin by Oral Intake of Linseed Oil Content Foods "Garlic Egg Yolk of Silky Fowl"

  SAWABE Akiyoshi

  Med Cons New-Remed (株)医事出版社 54 (12) 1133 - 1138 0037-380X 2017/12 [Refereed]
   

  α-リノレン酸を含む亜麻仁油食品である烏骨鶏のにんにく卵黄の摂取による肌の健康増進効果を調べるために、プラセボ食品を対照とした無作為化二重盲検並行群間試験を実施した。試験期間は、12週間であり、機器測定による皮膚水分量、経皮水分蒸散量、皮膚粘弾性および写真によるシワグレード判定を行った。その結果、皮膚水分量は、両群ともに摂取前と比較して有意に上昇した。また、経皮水分蒸散量も両群ともに摂取前と比較して有意に低下を示し、改善を示した。写真によるシワグレードの判定では、摂取12週後に亜麻仁油含有食品群がプラセボ食品群と比較して有意に改善を示し、亜麻仁油含有食品の摂取によるシワグレード改善効果が認められた。また、VAS法による自覚症状の変化においてもほうれい線やたるみの改善が認められたことから皮膚の粘弾性の改善も示唆された。シワグレードは目尻部のちりめん状の細かいシワも評価することから機器測定による変化だけで捉えきれない、皮膚の乾燥初期に生じる小さな変化を評価できたと考えられ、亜麻仁油含有食品の摂取は、冬場の顔部の乾燥だけでなく、夏場のクーラー環境など日常的に乾燥に曝される環境での生活者の手指の水分量やバリア機能の低下を改善することが考えられ、健康増進に繋がることが示された。(著者抄録)
• Subjective Evaluation and Variation on Skin Color after Ultraviolet Irradiation by Oral Intake of Ellagic Acid Content Foods "Irojiro Komachi" from Pomegranate

  SAWABE Akiyoshi

  Med Cons New-Remed (株)医事出版社 54 (12) 1126 - 1132 0037-380X 2017/12 [Refereed]
   

  「色白こまち」の皮膚に対する機能性を調べるために、人工的に紫外線を皮膚に照射し、照射後の皮膚色の変化および主観的評価をプラセボ照射無作為化二重盲検並行群間試験にて実施した。試験期間は4週間であり、機器測定による皮膚色の測定、VASアンケートによる主観的評価を行った。その結果、皮膚色測定においてb*値が被験食品摂取後にプラセボ食品と比較して有意に低下した。また、VASアンケートにおいては肌のツヤで被験食品摂取後にプラセボ食品と比較して有意に改善した。これらの結果は、「色白こまち」に含まれるエラグ酸の皮膚改善効果を示唆していると考えられる。(著者抄録)
• Effect of tablets containing lactononadecapeptide (NIPPLTQTPVVVPPFLQPE) on cognitive function in healthy middle-aged and senior adults.

  SAWABE Akiyoshi

  Jpn Pharmacol Ther 45 (8) 1303 - 1314 2017/08 [Refereed]
  
• Suppressive Effect of Acacia Polyphenol on Postprandial Blood Glucose Elevation in Non-diabetic Individuals - A Randomized, Double-blind, Placebo-controlled Crossover Study –

  SAWABE Akiyoshi

  Jpn. Pharmacol. Ther. 44 (10) 1463 - 1469 2016/10 [Refereed]
  
• Soy peptides exhibit superior absorption compared with protein beverages

  SAWABE Akiyoshi

  Jpn. J. Med Pharm Sci, 72 (7) 1227 - 1230 2015/07 [Refereed]
  
• 皮膚測定試験の種類に応じた被験者選定の考え方

  澤邊 昭義

  Cosmetic Stage 技術情報協会 9 (5) 63 - 66 1881-4905 2015/06
• The Effects on Restless Legs Syndrome and Intestinal Flora, to the Barley Extract Lactic Acid Bacterium in Japanese Women

  SAWABE Akiyoshi

  Pharmacometrics 応用薬理研究会 88 (5/6) 69 - 74 0300-8533 2015/06 [Refereed]
   

  大麦エキス乳酸菌発酵物の摂取がレストレスレッグス症候群(RLS)および腸内菌叢に及ぼす影響について検討した。成人日本人女性の中から、便秘や下痢の症状があり、かつRLSの症状を有する10例を対象とした。摂取前と比較して、後観察4週目にBacteroidesの割合は減少傾向を示し、Clostridium subcluster XIVaの割合は有意に増加した。アンモニア濃度は、摂取前と比較して摂取4週目および後観察4週目において有意差を認めなかった。摂取4週目および後観察4週目において排便回数が増加した。摂取前と比較してVASのスコアは、摂取4週目において、16項目が有意に減少し、2項目が減少傾向であった。また、摂取前と比較して後観察4週目では、15項目が有意に減少し、2項目が減少傾向であった。摂取期間中に試験食品に起因する重篤な有害事象および医師問診による異常は認めなかった。
• Antiallergic effect of the lactic acid bacterium combination louts root food

  澤邊 昭義

  食生活研究 食生活研究会 34 (6) 343 - 348 0288-0806 2014/09 [Refereed]
  
• Behavioral evidence for beneficial effects of soy peptide supplementation on higher brain function in healthy young volunteers

  SAWABE Akiyoshi

  Jpn Pharmacol Ther. 41 (5) 457 - 464 2013/05 [Refereed]
  
• 成人男性を対象とした、アルギン酸カルシウム含有食品の単回摂取による食後の血中中性脂肪値および血糖値におよぼす影響

  澤邊 昭義; 竹田 竜嗣; 福田靖 河内幸枝; 米虫節夫

  食生活研究 食生活研究会 33 (2) 109 - 114 2013/01 [Refereed]
  
• 成人女性を対象とした、アルギン酸カルシウム含有食品の摂取による脚のむくみに及ぼす影響

  澤邊 昭義; 竹田 竜嗣; 福田 靖; 河内 幸枝; 米虫節夫

  食生活研究 食生活研究会 33 (2) 102 - 108 2013/01 [Refereed]
  
• Nutrition and absorption of soy peptide, comparison with chicken extract

  SAWABE Akiyoshi

  Jpn. J. Med. Pharm. Sci. 自然科学社 67 (6) 843 - 848 2012/06 [Refereed]
  
• About the estrogenic activity and the stress reduction and a relaxation effect of odor after stress loading

  Akiyoshi Sawabe

  Aroma Research フレグランスジャーナル社 49 (1) 58 - 63 1345-4722 2012/02 [Refereed]
  
• THE FEASIBILITY OF USING MOSQUITOFISH (GAMBUSIA AFFINIS) FOR DETECTING ENDOCRINE-DISRUPTING CHEMICALS IN THE FRESHWATER ENVIRONMENT

  Ryo Kamata; Keisuke Itoh; Daisuke Nakajima; Shiho Kageyama; Akiyoshi Sawabe; Masanori Terasaki; Fujio Shiraishi

  ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY WILEY-BLACKWELL 30 (12) 2778 - 2785 0730-7268 2011/12 [Refereed]
   

  We evaluated the utility of gene-transcriptional responses in the liver of mosquitofish (Gambusia affinis), a species introduced to many countries and therefore widely available, for detecting endocrine-disrupting activity in water. Exposure to beta-naphthoflavone, an aryl hydrocarbon receptor (AhR) agonist, significantly increased the transcript of the cytochrome P4501A gene (cyp1a), peaking at 24 h, in both sexes at concentrations of 10 mu g/L or more. 17 beta-Estradiol (E(2)) at 500 ng/L increased the number of males showing gene transcription of precursors of yolk protein, vitellogenin (Vtga, Vtgb, and Vtgc), at 24, 48, and 72 h. Exposure for 48 h to bisphenol A (BPA), an estrogen mimic, also increased vtg-positive males at 1 mg/L or more. Leachate from a Japanese stable-type landfill significantly increased vtg-positive males after 48 h exposure, and the in vitro activity of the leachate against the estrogen receptor (ER) was estimated as an E(2) equivalent of 240 ng/L by yeast transfected with the ER. Chemical analysis showed that major contributors to the ER activation were BPA and 4-tert-octylphenol. This leachate and drainage water from a control-type landfill had AhR activities, estimated by yeast with the AhR, but had no significant effect on cyp1a transcription. These results showed that mosquitofish are suitable for detecting in vivo AhR and ER effects, but are insensitive to E(2). Environ. Toxicol. Chem. 2011;30:2778-2785. (C) 2011 SETAC
• Analysis of Relic Stopper Bottles with Liquid Excavated from Banshu Vineyard Remains

  沢辺 昭義

  日本ブドウ･ワイン学会誌 日本ブドウ・ワイン学会 22 (3) 143 - 147 1342-2324 2011/12 [Refereed]
  
• Water improvement of reservoir by using a microbubble generator

  沢辺 昭義

  環境管理技術 環境管理技術研究会 29 (6) 41 - 47 0289-1557 2011/12
• Easy quantitative evaluation of heavy metals in the soils and paddy-rice

  沢辺 昭義

  Journal of environmental control technique 環境管理技術研究会 29 (5) 31 - 39 0289-1557 2011/10
• Environmental investigation and bioassay of water flea of reservoirs in Nara

  沢辺 昭義

  Journal of environmental control technique 環境管理技術研究会 29 (5) 40 - 47 0289-1557 2011/10
• Aroma constituent production by the use of clonal technology:It smell from plant hairy roots!

  Akiyoshi Sawabe

  Koryo 日本香料協会 250 (250) 35 - 47 0368-6558 2011/06 [Invited]
  
• Effect of various food additives and soy constitutes on high CoQ10 absorption

  SAWABE Akiyoshi

  Jpn J Med Pharm Sci 64 (4) 613 - 620 2010/10 [Refereed]
  
• Behavior of glutathione and amino acid in Pb exposition to Cucurbita moschata

  沢辺 昭義

  Journal of environmental control technique 環境管理技術研究会 27 (4) 36 - 42 0289-1557 2009/08 [Refereed]
  
• Challenge the beauty! Botanical cosmetic materials

  沢辺 昭義

  Foods & food ingredients journal of Japan FFIジャーナル編集委員会 213 (10) 897 - 909 0919-9772 2008/10
• Glycemic index and glycemic load in starch origin food "Malony"

  沢辺 昭義

  食生活研究 食生活研究会 28 (3) 39 - 44 0288-0806 2008/03 [Refereed]
  
• Phylogenetic analysis of carotenoid-producing marine microorganisms around the coral reefs of the Kerama Islands of Okinawa

  Yasuji Sumiya; Satoshi Morita; Yasuhiro Nishida; Hideaki Sakaki; Miyuki Tsushima; Wataru Miki; Jin Tanangonan; Akiyoshi Sawabe; Yoshikazu Sakagami; Sadao Komemushi

  Biocontrol Science Society for Antibacterial and Antifungal Agents Japan 13 (1) 17 - 22 1342-4815 2008 [Refereed]
   

  Seawater sample from the coral reefs of the Kerama Islands of Okinawa were assessed for the presence of carotenoid-producing bacteria. Results of 16S rDNA analysis of the bacteria obtained from the isolated bacteria showed unique patterns that were different from those of the bacteria obtained from the ordinary marine area. Phylogenetic analysis revealed a slight correlation with the statistical analysis of the PDA chart patterns. The results suggest that useful materials for human health such as carotenoids can be extracted from many carotenoid-producing bacteria such as those found the coral reefs the Kerama Islands.
• Culture Characteristics of Carotenoid-producing Filamentous Fungus T-1, and Carotenoid Production

  SAWABE Akiyoshi

  J. Oleo Sci. Japan Oil Chemists' Society 56 (12) 649 - 652 1345-8957 2007/12 [Refereed]
   

  The culture characteristics, carotenoid production, and associated biosynthetic pathway of strain T-1 were examined. As a result of examining the culture temperature and light irradiation, an increase of neurosporaxanthin and neurosporaxanthin β-D-glucopyranoside was observed at a low temperature and 0 lx. It was suggested that highly polar carotenoids, such as neurosporaxanthin, and carotenoid glycosides were involved in the stabilization of membrane during nutrition storage other than the defense function of fungus bodies. Strain T-1 produced lycopene, β-carotene, γ-carotene, torulene, neurosporaxanthin, and neurosporaxanthin β-D-glucopyranoside, as assessed by HPLC, LC-MS, and NMR analysis. Carotenoid biosynthesis begins with neurosporene, passing to lycopene and γ-carotene through cyclization, and produces β-carotene. In addition, it is saturated, γ-carotene is converted to torulene, and neurosporaxanthin is produced. Thus, the carotenoid biosynthetic pathway in strain T-1 was estimated.
  
• Antibacterial activity of stilbene oligomers against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) and their synergism with antibiotics

  Yoshikazu Sakagami; Akiyoshi Sawabe; Sadao Komemushi; Zulfiqar Ali; Toshiyuki Tanaka; Ibrahim Iliya; Munekazu Iinuma

  Biocontrol Science Society for Antibacterial and Antifungal Agents Japan 12 (1) 7 - 14 1342-4815 2007 [Refereed]
   

  Two resveratrol trimers, gnemonol B isolated from Gnetum gnemon and gnetin E obtained from the Gnetum species, were found to exhibit strong antibacterial activities against vancomycin-resistant Enterococci (VRE) and methiclllin-resistant Staphylococcus aureus (MRSA). The MIC values of gnemonol B against five strains of VRE and nine strains of MRSA were 12.5 and 6.25 μ g/ml, respectively. The MIC values of gnetin E against five strains of VRE and nine strains of MRSA ranged from 12.5 to 25 μ g/ml. These compounds also showed synergistic effects when used in combination with commercially available antibiotics according to the evaluation method using FIC indices. These findings suggested that the application of the test compounds alone or in combination with antibiotics might be useful in controlling and treating VRE and MRSA infections.
• ファイトレメディエーション．Ⅶ －閉鎖系水域の環境問題－

  沢辺 昭義

  環境管理技術 環境管理技術研究会 24 (3) 35 - 38 0289-1557 2006/06
• ファイトレメディエーション．Ⅵ －土壌中における汚染物質（TPHおよびPAHs）の分解と代謝－

  沢辺 昭義

  環境管理技術 環境管理技術研究会 24 (2) 24 - 27 0289-1557 2006/04
• Chemical composition of three extracts of Bursera graveolens

  C Yukawa; Y Imayoshi; H Iwabuchi; S Komemushi; A Sawabe

  FLAVOUR AND FRAGRANCE JOURNAL JOHN WILEY & SONS LTD 21 (2) 234 - 238 0882-5734 2006/03 [Refereed]
   

  Three different extracts were separated by diethyl ether extraction, simultaneous steam distillation extraction and roasted aroma extraction (dry distillation) from Bursera graveolens. It was possible to identify 100 compounds in the three different extracts by GC-MS. The odour-active compounds present in the extracts were evaluated by gas chromatography-olfactometry (GC-0). It was estimated that mono- or sesquiterpenoids contributed to woody, herbal and minty aromas of the woody material of B. graveolens. On the other hand, the roast aroma produced by burning chips included several aroma compounds, such as cyclotene and vanillin. Copyright (c) 2005 John Wiley & Sons, Ltd.
• ファイトレメディエーション．Ⅴ －土壌中におけるPAHsの挙動－

  沢辺 昭義

  環境管理技術 環境管理技術研究会 24 (1) 44 - 48 0289-1557 2006/02
• Field investigation of pahs in soils around Nara city in Japan

  Takeda R; Ikuma Y; Matsumoto S; Komemushi S; Sawabe A

  Association for Environmental Health and Sciences - 21st Annual International Conference on Contaminated Soils, Sediments and Water 2005 11 325 - 335 2006 [Refereed]
  
• Accumulation of heavy metals by cucumber and brassica juncea under different cultivation conditions

  Takeda R; Sato Y; Yoshimura R; Komemushi S; Sawabe A

  Association for Environmental Health and Sciences - 21st Annual International Conference on Contaminated Soils, Sediments and Water 2005 11 279 - 285 2006 [Refereed]
  
• Toward Use of the Leaves of Perilla frutescens (L.) Britton var. Acuta Kudo (red perilla) with Japanese Dietary Pickled Plum (Umeboshi)

  Akiyoshi Sawabe; Takashi Satake; Ryosuke Aizawa; Keisuke Sakatani; Kouta Nishimoto; Chie Ozeki; Yoh Hamada; Sadao Komemushi

  Journal of Oleo Science 55 (8) 413 - 422 1347-3352 2006 [Refereed]
   

  Six phenolic compounds and one steroid were isolated from the leaves of Perilla frutescens Britton var. acuta (red perilla) with Japanese dietary pickled plum (Ume). These compounds were identified based on UV, MS, 1H-NMR and 13C-NMR spectroscopic data as β-sitosterol [1], shisonin [2], kaempferol 3-O-rutinoside [3], rosmarinic acid [4], rosmarinic acid methyl ester [5], 4-glucopyranosylcinnamic acid [6], and caffeic acid methyl ester [7]. In the bioassay, remarkable superoxide scavenging activity was found in the 1-butanol extract, and 20% methanol-water eluate, 50% methanol-water eluate and methanol eluate of an Amberlite XAD-2. In addition, remarkable superoxide scavenging activity was found in rosmarinic acid and rosmarinic acid methyl ester which are those isolation compounds. Moreover, we synthesized caffeic acid derivatives which were metabolic product of citrusin C and rosmarinic acid, and pharmacological effects such as superoxide scavenging activity used metabolite (vanillic acid, 4-hydroxy cinnamic acid, ferulic acid and isoferulic acid) of the chlorogenic acid as a starting material, and synthesized glycoside. And we examined their superoxide scavenging activity and tyrosinase inhibitory activity (Stepl as L-Tyrosine substrate Step 2 as L-DOPA substrate), and their synthesized compounds investigated for cosmetic use. As a result, for tyrosinase inhibitory activity, isoferulic acid (3,4-CA) and their methyl ester (3,4-CAM), good inhibition of 67.5 and 93.9% of Step 1 and 65.1 and 53.8% of Step 2 were noted. These compounds inhibited tyrosinase activity more than arbutin (63.0% of Step 1 and 7.7% of Step 2). For superoxide scavenging activity, ferulic acid (4,3-CA) and their methyl ester (4,3-CAM), and 4-hydroxy cinnamic acid (4-CA) were good activity of 43.6, 57.9 and 55.2%, respectively. Melanin inhibition and cytotoxicity were examined by using cultured B16 melanoma cells. More than 40% suppression was observed in 3-β-glucopyranosyl isoferulic acid methyl ester (3,4-CAGlc) and 4-hydroxy cinnamic acid methyl ester (4-CAM). © 2006, Japan Oil Chemists' Society. All rights reserved.
• Mono- and sesquiterpenoids of the volatile oil of Bursera graveolens

  C Yukawa; H Iwabuchi; S Komemushil; A Sawabe

  FLAVOUR AND FRAGRANCE JOURNAL JOHN WILEY & SONS LTD 20 (6) 653 - 658 0882-5734 2005/11 [Refereed]
   

  The characteristic spicy, sweet and balsamic aroma components of the woods of Bursera graveolens (palo santo) were measured using GC-MS. The characteristic four compounds, 1-4, were isolated from the diethyl ether extract. The structure of compounds 1 and 2 was elucidated by means of NMR studies, and confirmed to be 1-acetyl-4-isopropenyl-1-cyclopentene (1) and 2-methyl-5-isopropenyl-1-cyclopenten-1-carboxaldehyde (2) by synthesis from limonene oxide derivatives. The structure of compounds 3 and 4 was determined to be 6,10-epoxy-7(14)-isodaucane (3) and 10-hydroxy-6,10-epoxy-7(14)-isodaucane (4) by NMR experiments. Of these, compound 4 is a new sesquiterpenoid with a weak woody note, and the presence of compounds 1-4 in B. graveolens is reported here for the first time. Copyright (c) 2005 John Wiley & Sons, Ltd.
• ファイトレメディエーション．Ⅳ －植物の重金属集積メカニズム２－

  澤邊 昭義; 竹田 竜嗣; 米虫 節夫

  環境管理技術 環境管理技術研究会 23 (5) 47 - 51 0289-1557 2005/10
• Polycyclic aromatic hydrocarbons for the soil-plant-environment system

  SAWABE Akiyoshi

  J. Agric. Meteorol. 60 1137 - 1140 2005/10 [Refereed]
  
• Elucidation of a carotenoid biosynthesis gene cluster encoding a novel enzyme, 2,2 '-beta-hydroxylase, from Brevundimonas sp strain SD212 and combinatorial biosynthesis of new or rare xanthophylls

  Y Nishida; K Adachi; H Kasai; Y Shizuri; K Shindo; A Sawabe; S Komemushi; W Miki; N Misawa

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY AMER SOC MICROBIOLOGY 71 (8) 4286 - 4296 0099-2240 2005/08 [Refereed]
   

  A carotenoid biosynthesis gene cluster mediating the production of 2-hydroxyastaxanthin was isolated from the marine bacterium Brevundimonas sp. strain SD212 by using a common crtI sequence as the probe DNA. A sequence analysis revealed this cluster to contain 12 open reading frames (ORFs), including the 7 known genes, crtW, crtY, crtI, crtB, crtE, idi, and crtZ. The individual ORFs were functionally analyzed by complementation studies using Escherichia coli that accumulated various carotenoid precursors due to the presence of other bacterial crt genes. In addition to functionally identifying the known crt genes, we found that one (ORF11, named crtG) coded for a novel enzyme, carotenoid 2,2'-beta-hydroxylase, which showed intriguingly partial homology with animal sterol-C5-desaturase. When this crtG gene was introduced into E. coli accumulating zeaxanthin and canthaxanthin, the resulting transformants produced their 2-hydroxylated and 2,2'-dihydroxylated products which were structurally novel or rare xanthophylls, as determined by their nuclear magnetic resonance and high-performance liquid chromatography/photodiode array detector/atmospheric pressure chemical ionization mass spectrometry spectral data. The new carotenoid produced was suggested to have a strong inhibitory effect on lipid peroxidation.
• Glycosides in African Dietary Leaves, ┣DBHibiscus sabdariffa(/)-┫DB

  SAWABE Akiyoshi

  J. Oleo Sci. Japan Oil Chemists' Society 54 (3) 185 - 191 1345-8957 2005/03 [Refereed]
   

  Seven glycosides were isolated from African dietary leaves, Hibiscus sabdariffa. Their structures were determined based on UV, MS, ¹H-NMR and ¹³C-NMR spectroscopic data as kaempferol 3-O-rutinoside [1], kaempferol 3-O-glucopyranoside [2], quercetin 3-O-rutinoside [3], citrusin C [4], 2,3-dihydro-2-(4′-hydroxy-3′-methoxyphenyl)-3-β-D-glucopyranosylmethyl-7-hydroxy-5-benzofuranpropanol [5], corchoionoside C [6], and trans-carveol 6-O-β-glucopyranoside [7]. In the bioassay with superoxide scavenging activity, 1-BuOH extract, acidic components, neutral components, compound 3 and aglycone of 3 (3a) showed strong activity. And in the tyrosinase inhibitory activity, aglycone of 1 (1a) and aglycone of 3 (3a) showed good inhibition. As a result, we considered that Hibiscus sabdariffa may be related to the longevity, and their 1-BuOH extract was found promising as a cosmetic agent. The presence of compounds 4-7 in the leaves of Hibiscus sabdariffa is reported here for the first time.
  
• Behavior of heavy metals in the callus of Brassica juncea, a heavy metal accumulation plant

  Toru Yamada; Ryuji Takeda; Yusuke Tsuda; Sadayoshi Matsumoto; Sadao Komemushi; Akiyoshi Sawabe

  Bunseki Kagaku 54 (9) 929 - 933 0525-1931 2005 [Refereed]
   

  To find a more efficient phytoremediation, the accumulation mechanism of elucidating heavy metals of a hyperaccumulator is important. We measured the behavior and glutathione quantity of the heavy metal accumulation level in calli using Brassica juncea, which is a hyperaccumulator of Pb and Cd. Brassica juncea from a seed was used to grow callus, which was for three months. Then, for two weeks, we conducted long-term exposure to a culture in heavy-metal component culture media (Cr, Cu, Zn, Cd, Pb, Co, Ni). Furthermore, we used a liquid culture medium for Pb, we conducted a short-term exposure for five days. As for Cd and Pb, the absorbed dose was high, and the Cd, in particular, showed the absorbed dose to be high at a low concentration (10-100 μM), compared with other heavy-metal classes. There were many things that necrotized, in other heavy metals, the fastness was not found to influence the heavy metal. In the short-term exposure of Pb, the absorption level increased during the early phase. However, 96 hours later, according to the cell cycle, that absorption appeared to be promoted. In addition, in GSH, while a large difference was not recognized, a high concentration level was much contained it. © 2005 The Japan Society for Analytical Chemistry.
• Terpenoids of the volatile oil of Bursera graveolens

  Chiyoki Yukawa; Hisakatsu Iwabuchi; Tadao Kamikawa; Sadao Komemushi; Akiyoshi Sawabe

  Flavour and Fragrance Journal 19 (6) 565 - 570 0882-5734 2004/11 [Refereed]
   

  In the course of studies on the constituents of the woody material of Bursera graveolens, the aroma components that provide its characteristic spicy, sweet and balsamic odor were investigated using GC/MS. Five compounds, 1-5, were isolated from the volatile oil obtained by diethyl ether extraction of B. graveolens wood chips, and their structures were elucidated by means of NMR studies. Their structures were determined as (-)-dihydro-α-agarofuran (1), (-)-5,11-epoxy-4α,5β,10α-eudesm-1-ene (2), (-)-4α-hydroxydihydroagarofuran (3), (-)-3β,4β -oxidoagarofuran (4) and (-)-10-epi-γ-eudesmol (5). Of these, (-)-5,11-epoxy-4α,5β,10α-eudesm-1-ene (2) is a new sesquiterpenoid that has not previously been reported in literature, and the presence of (-)-dihydro-α-agarofuran (1), (-)-4α -hydroxydihydroagarofuran (3), (-)-3β,4β-oxidoagarofuran (4) and (-)-10-epi-γ-eudesmol (5) in B. graveolens is reported for the first time. Copyright © 2004 John Wiley & Sons, Ltd.
• Inhibitory actions of several natural products on proliferation of rat vascular smooth muscle cells induced by Hsp60 from Chlamydia pneumoniae J138

  K Fukuoka; A Sawabe; T Sugimoto; M Koga; H Okuda; T Kitayama; M Shirai; K Komai; S Komemushi; K Matsuda

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY AMER CHEMICAL SOC 52 (20) 6326 - 6329 0021-8561 2004/10 [Refereed]
   

  Atherosclerosis is a vascular disorder involving inflammation, a narrowed vascular lumen in the entire tunica intima, and reduced elasticity of the arterial wall. It has been found that Hsp60 from Chlamydia pneumoniae, an obligate bacterial pathogen associated with atheroma lesions, mimics human Hsp60, thereby causing attacks by immune cells on stressed endothelial cells expressing endogenous Hsp60 on their surface. Furthermore, Hsp60 from C. pneumoniae has been shown to promote the growth of vascular smooth muscle cells (VSMCs). To explore probes that can be used for studying signal transduction elicited by the chlamydial Hsp60, we have tested several natural products for their inhibitory actions on the Hsp60-induced proliferation of rat arterial smooth muscle cells. Sesamol, vanillyl alcohol, and trans-ferulic acid exhibited moderate inhibitory actions on the Hsp60-induced cell proliferation; zerumbone, humulene, and caryophylene effectively inhibited it at low concentrations with IC(50) values of 529, 122, and 110 nM, respectively. The results indicated that the 11-membered alicyclic ring is favorable for interactions with receptors involved in the Hsp60-induced VSMC proliferation.
• Field investigation of PAHs in soils around Nara city

  Ryuji Takeda; Yoshimasa Ikuma; Sadayoshi Matsumoto; Sadao Komemushi; Akiyoshi Sawabe

  Bunseki Kagaku 53 (9) 1003 - 1008 0525-1931 2004/09 [Refereed]
   

  PAHs are the general term of the compounds, having two or more benzene rings. These are discharged from diesel motor gas, tanker accidents, oil emissions by cars, and so on. They float in the atmosphere, and it is considered that they are absorbed in soil as a result of rain. Generally, compounds that have two or three benzene rings show only toxicity, whereas these having four or more benzene rings show toxicity, carcinogenicity and mutagenicity. Especially, benzo(a)pyrene was shown to be an agency of an endocrine disrupter. We investigated the action of 16 PAHs specified by the U.S. EPA in soil around Nara city. Soil was collected from different locations involving traffic and vegetation. Soil from three locations around our uni-versity were collected every month for investigating seasonal movement. PAHs were extracted from soil by soxhlet extraction with dichloromethane. They were then analyzed quantitatively by HPLC/UV. We classed PAHs by the number of rings, and examined the concentration and seasonal movements. All content of 16 PAHs in soils increased in proportion to traffic volume. At the same locations of traffic volume, the gravitation at a location with a plant with all 16 PAHs in soils was, furthermore, found to have a low concentration. There were different seasonal movements of the 2,3-ring and 4, 5, 6-ring PAHs. 4, 5, 6-ring PAHs have strong correlations each others(r > 0.79), but there was no correlation between 2, 3-ring and 4, 5, 6-ring PAHs. As a result, the traffic volumes are exposition sources of 4, 5, 6-ring PAHs in soils.
• Carotenoids and Flavonoids from Saffron (Crocus sativus L.): Assessment of cosmetic use

  SAWABE Akiyoshi

  Carotenoid Rresearch 7 37 - 38 2004/04 

  サフランに含まれる２種類のカロテノイド，２種類のフラボノイドおよび２種類のものテルペノイドの合計６種の成分を抽出・単離し，それらの構造を明確にした。得られた成分の光・温度・pHの耐性テストを行うとともにチロシナーゼ活性阻害試験および活性酸素抑制試験により化粧品有用性について検討した。
• Accumulation of Heavy Metals by Japanese Weeds and their Seasonal Movement

  SAWABE Akiyoshi

  Soil & Sediment Contamination 13 222  2004/04 

  近畿大学農学部キャンパス（奈良市）をはじめ，木津川河原，車通りの多い奈良市内県道周辺，奈良市内ガソリンスタンド跡地など様々な立地環境における30種類以上の草本植物を採取し，季節間の重金属の集積量を調査した。（英文）
• Eudesmane-Type Sesquiterpenoids in the Volatile Oil from Bursera graveolens

  Chiyoki Yukawa; Hisakatsu Iwabuchi; Sadao Komemushi; Akiyoshi Sawabe

  Journal of Oleo Science 53 (7) 343 - 348 1347-3352 2004 [Refereed]
   

  In the course of studies on the constituents of the woody material of Bursera graveolens, the aroma components that provide its characteristic spicy, sweet and balsamic odor were investigated using gas chromatography/olfactometry (GC/O) and GC/MS. Four compounds 1-4 were isolated from the volatile oil obtained by diethyl ether extraction of B. graveolens wood chips, and their structures were elucidated by means of NMR studies. Their structures were determined as (-)-juneol (1), dihydrojuneol (2), 6β-hydroxy-4(15)-eudesmen-1-one (3) and 6β-hydroxynoreudesman-4-one (4). The presence of these compounds in B. graveolens is reported for the first time. © 2004, Japan Oil Chemists' Society. All rights reserved.
• 58(P-31) A New Carotenoid Glycoside Isolated from a Marine Microorganism, Strain T-1 : Structural Determination and Cultural Characteristic

  Hioki Kazuya; Sumiya Yasuji; Kaneno Hirokazu; Kishimoto Noriaki; Fujita Tokio; Matsumoto Sadayoshi; Komemushi Sadao; Sawabe Akiyoshi; Tsushima Miyuki; Sakaki Hideyuki; Miki Wataru

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (45) 341 - 346 2003/09 

  The surface of the sea in tropical and subtropical region is a severe environment for the growth of organisms, because active oxygen and free radicals are generated by intense irradiation with strong sunlight. Recently, it has been reported that the marine microorganisms Agrobacterium aurantiacum produced astaxanthin, which has one of the strongest ^1O_2 quenching activities. Then, focusing on fungal type marine microorganisms, we screened ocean fungus for production of excellent carotenoid with antioxidative activity. Here we report on the structural determination and cultural characteristic of a new carotenoid from marine microorganisms. Strain T-1 producing orange pigment was isolated from the surface of sea water at Tanegashima, Kagoshima Prefecture in Japan in August 1999 and identified as a Fusarium sp. The microorganism was cultured in a 10-liter scale at 25℃ for 7 days on a reciprocal shaker, using a modified marine broth medium. The cultured cells were concentrated by centrifugation, then extracted with acetone. After separation and purification by column chromatography on silica gel and HPLC, successively, structures of the carotenoids were analyzed using UV-VIS, MS, ^1H- and ^<13>C-NMR spectrometry. Neurosporaxanthin β-D-glucopyranoside was identified as a new carotenoid from the strain. A yield of carotenoid in 1g freeze-dried fungus body was found to be 0.25mg. Main carotenoids of the strain were neurosporaxanthin (45% out of the all carotenoids), γ-carotene (32%) and the new carotenoid neurosporaxanthin β-D-glucopyranoside (11%). β-Carotene (5%) and torulene (3%) were minor constituents.
• Evaluation for Efficient Hairy Root Production Assessed by GFP-gene Expression in Tomato Cultivars Inoculated with Agrobacterium rhizogenes MAFF07 20001

  Takeshi Fukumoto; Teruo Nonomura; Yoshinori Matsuda; Shin-ichirou Komaki; Nobuyuki Moriurai; Hideyoshi Toyoda; Koji Kakutani; Akiyoshi Sawabe

  Plant Biotechnology 20 (3) 257 - 261 1347-6114 2003 [Refereed]
   

  When leaf segments of a tomato cultivar 'Ponderosa' were inoculated with Agrobacterium rhizogenes MAFF07-20001 carrying the binary vectors pRi and pBI121/sGFP, adventitious roots were developed from calli formed at the edges of the segments. Primordial roots were obtained with green fluorescence under blue light and elongated vigorously on hormone-free medium without loss of the green fluorescence. They were easily distinguishable from the non-fluorescing roots on the same segments. Successful integration of the sGFP and rol C genes into the chromosome of tomato roots was confirmed by polymerase chain reaction and Southern hybridization. The present method enables us to evaluate the hairy root formation without subculture, isolation and DNA analysis. All commercial cultivars available in Japan (24 cultivars) and 14 breeding lines of tomato were tested by this method. All but two breeding lines produced the hairy roots. Thus, the present method is useful for hairy root production in tomato. © 2003, Japanese Society for Plant Cell and Molecular Biology. All rights reserved.
• Constituents of Volatile Oil from Melon Hairy Roots Produced by the Infection with Agrobacterium rhizogenes

  Akiyoshi Sawabe; Yoshinori Matsuda; Hideyoshi Toyoda; Kazuhiko Maeda; Teruo Nonomura; Naoto Shimizu; Naoko Fujita; Seiji Ouchi

  Journal of Oleo Science 52 (3) 171 - 174 1347-3352 2003 [Refereed]
   

  Volatile oils were obtained from melon hairy roots produced by the infection with Agrobacterium rhizogenes, and their constituents were analyzed by GC and GC-MS spectroscopy. Characteristic major components were 1-nonanal, (Z)-6-nonenol, and (E, Z)-2, 6-nonadienal. The melon hairy roots are thus shown to produce volatile components with the fragrance of ripe melon fruit. © 2003, Japan Oil Chemists' Society. All rights reserved.
• Evaluation for Efficient Hairy Root Production Assessed by GFP-gene Expression in Tomato Cultivars Inoculated with Agrobacterium rhizogenes MAFF07 20001

  Takeshi Fukumoto; Teruo Nonomura; Yoshinori Matsuda; Shin-ichirou Komaki; Nobuyuki Moriurai; Hideyoshi Toyoda; Koji Kakutani; Akiyoshi Sawabe

  Plant Biotechnology 20 (3) 257 - 261 1347-6114 2003 [Refereed]
   

  When leaf segments of a tomato cultivar 'Ponderosa' were inoculated with Agrobacterium rhizogenes MAFF07-20001 carrying the binary vectors pRi and pBI121/sGFP, adventitious roots were developed from calli formed at the edges of the segments. Primordial roots were obtained with green fluorescence under blue light and elongated vigorously on hormone-free medium without loss of the green fluorescence. They were easily distinguishable from the non-fluorescing roots on the same segments. Successful integration of the sGFP and rol C genes into the chromosome of tomato roots was confirmed by polymerase chain reaction and Southern hybridization. The present method enables us to evaluate the hairy root formation without subculture, isolation and DNA analysis. All commercial cultivars available in Japan (24 cultivars) and 14 breeding lines of tomato were tested by this method. All but two breeding lines produced the hairy roots. Thus, the present method is useful for hairy root production in tomato. © 2003, Japanese Society for Plant Cell and Molecular Biology. All rights reserved.
• Constituents of Volatile Oil from Melon Hairy Roots Produced by the Infection with Agrobacterium rhizogenes

  Akiyoshi Sawabe; Yoshinori Matsuda; Hideyoshi Toyoda; Kazuhiko Maeda; Teruo Nonomura; Naoto Shimizu; Naoko Fujita; Seiji Ouchi

  Journal of Oleo Science 52 (3) 171 - 174 1347-3352 2003 [Refereed]
   

  Volatile oils were obtained from melon hairy roots produced by the infection with Agrobacterium rhizogenes, and their constituents were analyzed by GC and GC-MS spectroscopy. Characteristic major components were 1-nonanal, (Z)-6-nonenol, and (E, Z)-2, 6-nonadienal. The melon hairy roots are thus shown to produce volatile components with the fragrance of ripe melon fruit. © 2003, Japan Oil Chemists' Society. All rights reserved.
• Synthesis and Cosmetic Whitening Effect of Glycosides Derived from Anacardic Acids

  Kazuo Kasemura; Masato Nomura; Akiyoshi Sawabe; Yoshihito Fujihara

  Journal of Oleo Science 52 (3) 141 - 147 1347-3352 2003 [Refereed]
   

  Anacardic acids, (6-[(8Z)-8-pentadecenyl] salicylic acid (1) and 6-[(8Z,11Z)-8, 11,14-pentadecatrienyl] salicylic acid (2)) were isolated from the shell oil of Indonesian cashew nut and used to synthesize glycosides via glycosidation of the carboxyl group on the benzene ring. We examined these compounds for their inhibition of the enzyme tyrosinase, their superoxide scavenging activity and their inhibition of enzyme hyaluronidase. The glucosides derived from (1) and (2) were found to inhibit tyrosinase (using L-DOPA as a substrate) activity by more than 80%. The inhibitory rates exceeded that of arbutin, a compound that is used in commercial cosmetics. As the comparison, cardanols, (3-[(8Z)-8-pentadecenyl] phenol (3) and 3-[(8Z, 11Z)-8, 11, 14-pentadecatrienyl] phenol (4)) were isolated from the cashew nut shell oil and used to synthesize glycosides that we also examined for their inhibitory activity. © 2003, Japan Oil Chemists' Society. All rights reserved.
• A new carotenoid glycosyl ester isolated from a marine microorganism, Fusarium strain T-1

  H Sakaki; H Kaneno; Y Sumiya; M Tsushima; W Miki; N Kishimoto; T Fujita; S Matsumoto; S Komemushi; A Sawabe

  JOURNAL OF NATURAL PRODUCTS AMER CHEMICAL SOC 65 (11) 1683 - 1684 0163-3864 2002/11 [Refereed]
   

  A new carotenoid glycosyl ester, neurosporaxanthin beta-D-glucopyranoside (2), together with neurosporaxanthin (1), beta-carotene, gamma-carotene, and torulene were isolated from cultured cells of a marine microorganism, strain T-1, which was identified as Fusarium sp. Their structures were determined by chemical and spectral data.
• Isolation and Synthesis of Cosmetic Substances from African Dietary Leaves, Celosia argentea L. For Skin Depigmentation

  Akiyoshi Sawabe; Masato Nomura; Yoshihito Fujihara; Takahiro Tada; Fumihiro Hattori; Satoko Shiohara; Kenji Shimomura; Yoshiharu Matsubara; Sadao Komemushi; Tadashi Okamoto; Saburou Kawamura

  Journal of Oleo Science 51 (3) 203 - 206 1347-3352 2002 [Refereed]
   

  Six compounds were isolated from the leaves of Celosia argentea L. Tyrosinase inhibitory and superoxide scavenging activity of the compounds was examined so as to obtain a skin depigmentation agent for cosmetic application. Eugenyl Oβ-D-glucopyranoside (citrusin C, 1) showed strong tyrosinase inhibitory activity. Two-step inhibitory effects of successive tyrosine and DOPA oxidation for tyrosinase were stronger compared to arbutin used commercially at present (47.20% inhibition of tyrosine oxidation and 87.93%, DOPA oxidation, compared to 63.00% for tyrosine and 7.70% for DOPA oxidation in the case of arbutin). Moreover, we succeed in providing compound 1 abundantly in the synthetic study which used acetobromo-α-D-glucose and Sn(OTf)2-J. Oleo Sci., 51, 203-206 (2002).© 2002, Japan Oil Chemists’ Society. All rights reserved.
• 55(P-12) Investigation of Cosmetic Substances for Skin Depigmentation from African Dietary Leaves, Hibiscus sabdariffa

  Sawabe Akiyoshi; Yamamoto Satoshi; Matsumoto Sadayoshi; Okamoto Tadashi; Matsubara Yoshiharu; Kawamura Saburou; Komemushi Sadao; Morita Masanori; Hattori Fumihiro; Shimomura Kenji; Fujihara Yoshihito; Nomura Masato

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (43) 323 - 328 2001/09 

  Sierra Leone is a country located in the Middle West of Africa, where people enjoy longevity. It is interesting, therefore, to know what may be the cause of their long lives. Assuming that their foods may be related to the longevity, we started to investigate the constituents in the leaves of Hibiscus sabdariffa, which is used for diet in the country. Hibiscus sabdariffa grows in the torrid zone of Africa by origin. Previously, we isolated six compounds from the leaves of African Celosia argentea L. and investigated their effect on the skin depigmentation. In this report, we describe the isolation and identification of functional molecules in the leaves of African Hibiscus sabdariffa, and their effect on the skin depigmentation. Five compounds were isolated from the leaves of Hibiscus sabdariffa and their structures were determined based on MS, ^1H-NMR and ^<13>C-NMR spectroscopic data as kaempferol 3-O-rutinoside (1), kaempferol 3-O-glucopyranoside (2), quercetin 3-O-rutinoside (3), citrusin C (4), and corchoionoside C (5). Among them, compounds 1a (kaempfrol) and 4 (citrusin C) showed a good skin depigmentation effect.
• アルギニン・グルタミン混合物による高齢者の褥瘡および低栄養改善効果の検討

  沢辺 昭義

  臨床栄養 118 (2) 188 - 204 2001/02 [Refereed]
  
• Cosmetic Substances for Skin Depigmentation from African Dietary Leaves,L.

  SAWABE Akiyoshi

  Bull. Inst. Compr. Agr. Sci. Kinki Univ. 近畿大学農学総合研究所 (9) 141 - 146 0919-3022 2001 

  [Synopsis] Sierra Leone is a country located in the Middle West of Africa, where people enjoy longevity. It is interesting, therefore, to know what may be the cause of their long lives. Assuming that their foods may be related to the longevity, we started to investigate the constituents in the leaves of Celosia argentea L., which is used for diet in the country. Celosia argentea L. grows in the torrid zone of Africa by origin, and is also found in a warm place of the westward of Japan. Some terpenoids and saponins in the roots, and flavonoids in the leaves and stems have been implicated as active constituents in Celosia argentea L.. Here we describe an investigation of functional molecules in the leaves of African Celosia argentea L., and their effect on the skin depigmentation. Six compounds were isolated from the leaves of Celosia argentea L. and their structures were determined based on UV, MS, ^1H-NMR and ^<13>C-NMR spectroscopic data as 1-(4-O-β-glucopyranosyl-3-methoxyphenyl) propan-2-ene (citrusin C, 1), 3-O-β-glucopyranosyl-1H- indole (indican, 2), (3Z)-hexenyl-1-O-(6-O-α-rhamnopyranosyl- β-glucopyranoside) (3), (3Z)-hexenyl- 1-O-β-glucopyranoside (4), (7E)-6,9-dihydromegastigma-7-ene-3-one-9-O-β-glucopyranoside (5), and trans- ferulic acid (6). Among them, compound 1 (citrusin. C) showed good skin depigmentation effect. The presence of compounds 1-6 in the leaves of Celosia argentea L. is reported here for the first time.
• Structural Characterization of a Precursory Substance of Bitterness, New Polyisoprenepolyols Isolated from an Edible Mushroom by FAB/MS

  SAWABE Akiyoshi

  Bull. Inst. Compr. Agr. Sci. Kinki Univ. 近畿大学農学総合研究所 (9) 97 - 105 0919-3022 2001 

  [Synopsis] Fast atom bombardment (FAB) mass spectrometry enables analyses in the positive and negative ion modes, providing different information. Therefore, the method is a powerful tool for analyzing the structure of polyisoprenepolyols. Although some of the structural information is available from routine FAB mass spectra, the linked scan spectra provides information in more detail. In this paper, we briefly review our recent works and describe the structural elucidation of polyisoprenepolyols isolated from an edible mushroom (Hypsizygus marmoreus) by FAB mass spectrometry. （摘要）きのこ（ブナシメジ、Hypsizygus marmoreus）の苦味成分と考えられる新規ポリイソプレンポリオールの分離に成功し、それらの構造解析にFAB/MSが有効な手法であることを示した。また、混合物であってもFAB/MSを用いることによって、上記化合物の構造特性を探ることができた。
• 130(P-76) Synthesis and Cosmetic Whitening Effects of Glycoside of Salicylic Acids from Cashew Nut Shell Oil

  Kasemura Kazuo; Nomura Masato; Fujihara Yoshihito; Sawabe Akiyoshi; Morita Masanori; Tada Takahiro; Shimomura Kenji

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (42) 775 - 780 2000/10 

  Pollution by chlorofluorohydrocarbons from freezers and air conditioners has recently contributed to the destruction of the ozone layer and it has been suggested that excessive exposure to ultraviolet rays causes serious problems such as carcinogenesis, inflammation, and photo-aging. The investigation of natural products have been increased expecting the effectiveness and safety. We have previously reported that 6-[(8Z)-8-pentadecenyl] salicylic acid (1) (Anacardic acid monoene) and 6-[(8Z, 11Z)-8, 11, 14- pentadeca trienyl] salicylic acid (2) (Anacardic acid triene) were isolated from cashew nut shell oil and their derivatives showed strong tyrosinase inhibitory activity. In this report, we synthesized eight derivatives from (1), (2), 3-[(8Z)-8-pentadecenyl] phenol (3) (Cardanol monoene) and 3-[(8Z, 11Z)-8, 11, 14-pentadecatrienyl] phenol (4) (Cardanol triene) by condensation and hydrolysis reactions using 2,3,4,6-tetra-o-acetyl-α-D-glucopyranosyl bromide and 2,3,4,6-tetra-o-acetyl-α-D-e galactopyranosyl bromide. These derivatives were examined for their use as whitening agents which inhibit tyrosinase activity, superoxide scavenging activity and hyaluronidase activity. Compounds (1a) and (2a) were found to be inhibited by ca. 81-88% tyrosinase activity (L-Dopa). This inhibitory action considerably exceeded that of arbutin used in commercial cosmetics.
• Characterization of acetylenes and Terpenoids from ┣DBSolidago(/)-┫DB ┣DBaltissima(/)-┫DB

  SAWABE Akiyoshi

  Bull. Inst. Compr. Agr. Sci. Kinki Univ. 近畿大学農学総合研究所 (8) 81 - 88 0919-3022 2000 

  [Synopsis] Four acetylenes and three terpenoids were isolated from Solidago altissima L. and characterized by MS, 'H-NMR and ^<13>C-NMR spectroscopy as methyl (Z)-decaene-4,6,8-triynoate (Zdehydromatricaria ester, 1), methyl 10-[(Z)-2-methyl-2-butenoyloxy]-(2Z,84-2,8-decadiene-4,6-diyoate (2), (4Z-2,4-decadiene-6,8-diyn-4-olide (Z-dehydromatricaria lactone, 3), (4E)-2,4-decadiene-6,8-diyn-4-olide (E-dehydromatricaria lactone, 4), 13E,7 α-acetoxyl kolavenic acid (solidagonic acid, 5), kolavenol (6), and D:C-friedours-7-en-3 β-ol (ilexol, 7). The polyacetylenes could be easily detected as yellowish brown spots on TLC plate following irradiation with blue black light for two to three minutes. The Z and E isomers of dehydromatricaria lactones were easily differentiated based on differences in melting points and chemical shifts of ^1H- and ^<13>C-NMR spectroscopy. Bioassay of these compounds on the germination of lettuce seeds showed that compounds 1, 2, 3, 4, and 5 exhibited growth inhibitory activity, whereas compound 7 did not exhibit the activity. This study presents the first isolation of (E)-dehydromatricaria lactone from Solidago altissima L. in nature. （摘要） Solidago altissima L..から単離した4種のアセチレンおよび3種のテルペン、methyl (z)-decaene-4,6,8-triynoate (Z-dehydromatricaria ester, 1), methyl 10-[(Z)-2-methy 1-2-butenoyloxy]-(2Z,8Z)-2,8-decadiene-4,6-diyoate (2), (4Z)-2,4-decadiene-6,8-diyn-4-olide (Z-dehydromatricaria lactone, 3), (4E)-2,4-decadiene-6,8-diyn-4-olide (E-dehydromatricaria lactone, 4) 13E,7 α-acetoxyl kolavenic acid (solidagonic acid, 5) kolavenol (6), D:C-friedours-7-en-3β-ol (ilexol, 7)について発芽に対する影響をレタスを用いて検討した。その結果、化合物 1,2,3,4 および5は生長阻害作用を示し、化合物7は活性を示さなかった。ポリアセチレンは、TLC上で2, 3分ブルーブラックライトの照射によって黄茶色のスポットとして、容易に確認できた。 Dehydromatricaria lactones のZ体およびE体は、融点の違い、また、^1H-および^<13>C-NMRのケミカルシフトの違いによって、容易に確認できた。なお、単離した成分のうち、（E)-dehydromatricaria lactone (4)は天然物としてSolidago altissima L. から初めて見出した成分である。
• Cosmetic substances for skin depigmentation from African dietary leaves, ┣DBCelosia argenta(/)-┫DB-L.

  Fragrance Journal 28 (9) 54  2000
• A hairy root culture of melon produces aroma compounds

  Yoshinori Matsuda; Hideyoshi Toyoda; Akiyoshi Sawabe; Kazuhiko Maeda; Naoto Shimizu; Naoko Fujita; Takumi Fujita; Teruo Nonomura; Seiji Ouchi

  Journal of Agricultural and Food Chemistry 48 (4) 1417 - 1420 0021-8561 2000 [Refereed]
   

  Musk melon is the favorite fruit with a high market value in Japan, and the fragrance is one of the major factors determining the fruit quality of melon. In this study, mutant melon hairy roots which had been induced by means of the T-DNA insertion mutagenesis were found to produce volatile compounds with the fruity fragrance of mature melon. The volatile compounds were extracted and identified by GLC-mass spectrometry. Some essential oils such as (Z)-3-hexenol, (E)-2-hexenal, 1-nonanol, and (Z)-6-nonenol were stably synthesized by these hairy roots despite the increased number of subcultures. The productivity of these compounds by the best hairy root line was shown to be considerably higher than naturally ripened melon fruits.
• 94(P36) Isolation and Synthesis of Cosmetic Substances for Skin Depigmentation from African Dietary Leaves, Celosia argentea L.

  Sawabe Akiyoshi; Matsubara Yoshiharu; Iwasaki Masayo; Okamoto Tadashi; Morita Masanori; Tada Takahiro; Hattori Fumihiro; Shiohara Satoko; Shimomura Kenji; Nishimura Kazuhiko; Fujihara Yoshihito; Nomura Masato

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (41) 559 - 564 1999/09 

  Sierra Leone is a country located in the Middle West of Africa, where people enjoy longevity. It is interesting, therefore, to know what may be the cause of their long lives. Assuming that their foods may be related to the longevity, we started to investigate the constituents in the leaves of Celosia argentea L., which is used for diet in the country. Celosia argentea L. grows in the torrid zone of Africa by origin, and is also found in a warm place of the westward of Japan. Some terpenoids and saponins in the roots, and flavonoids in the leaves and stems have been implicated as active constituents in Celosia argentea L., Here we describe the isolation and identification of functional molecules in the leaves of African Celosia argentea L., and their effect on the skin depigmentation. Six compounds were isolated from the leaves of Celosia argentea L. and their structures were determined based on UV, MS, ^1H-NMR and ^<13>C-NMR spectroscopic data as 1-(4-O-β-glucopyranosyl-3-methoxyphenyl) propane-2-ene (citrusin C, 1), 3-O-β-glucopyranosyl-1H-indole (indican, 2), (3Z)-hexenyl-1-O-(6-O-α-rhamnopyranosyl-β-glucopyranoside) (3), (3Z)-hexenyl-1-O-β-glucopyranoside (4), (7E)-6,9-dihydromegastigma-7-ene-3-one-9-O-β-glucopyranoside (5), and trans-ferulic acid (6). Among them, compound 1 (citrusin C) showed a good skin depigmentation effect. The presence of compounds 1-6 in the leaves of Celosia argentea L. is reported here for the first time.
• Structural analyses of a precursory substance of bitterness: New polyisoprenepolyols isolated from an edible mushroom (Hypsizigus marmoreus) by fast atom bombardment mass spectrometry

  A Sawabe; M Morita; T Kiso; H Kishine; Y Ohtsubo; S Ouchi; T Okamoto

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY AMER CHEMICAL SOC 47 (2) 588 - 593 0021-8561 1999/02 [Refereed]
   

  New polyisoprenepolyols (hypsiziprenol AA and BA) were isolated from an edible mushroom (Hypsizigus marmoreus). These polyols occur as a mixture of homologous polyisoprene derivatives with 40-70 carbon atoms. Analyses by FAB/MS in the positive and negative ion modes are complementary with each other in that the former provides information on the number of hydroxy groups present while the latter specifies the isoprenoid sequence, and thus become a powerful tool for analyzing the structures of polyisoprenepolyols. No polyisoprenepolyols obtained here were found to have antitumor activity on NCI-H292 and EL-4 cell lines.
• Isolation and characterization of new limonoid glycosides from Citrus unshiu peels

  Akiyoshi Sawabe; Masanori Morita; Tatsuya Kiso; Hideki Kishine; Yoshikazu Ohtsubo; Toshie Minematsu; Yoshiharu Matsubara; Tadashi Okamoto

  Carbohydrate Research 315 (1-2) 142 - 147 0008-6215 1999/01 [Refereed]
   

  Three limonoid glycosides were isolated from Citrus unshiu peels, and their structures were determined based on MS and NMR spectroscopic data as nomilinic acid 17-O-β-D-glucopyranoside (1), methyl nomilinate 17-O-β-D-glucopyranoside (2), and obacunone 17-O-β-D-glucopyranoside (3). In particular, the location of the sugar moiety was clearly determined by the B/E constant linked scan FABMS method. No limonoid glycosides obtained here were found to have antitumor activity in NCI-H292 and EL-4 cell lines. Copyright (C) 1999 Elsevier Science Ltd.
• Investigation of functional molecules in African Celosia argentea L.

  A Sawabe; T Obata; Y Nochika; M Morita; N Yamashita; Y Matsubara; T Okamoto

  ADVANCES IN PLANT GLYCOSIDES, CHEMISTRY AND BIOLOGY ELSEVIER SCIENCE BV 6 290 - 296 1999 [Refereed]
   

  Five glycosides were isolated from the leaves of Celosia argentea L. and their structures were determined based on UV, MS,H-1 NMR and C-13 NMR spectroscopic data as 1-(4-O-beta-glucopyranosy1-3-methoxyphenyl) propane-2-ene (citrusin C, 1), 3-O-beta-glucopyranosyl-1H-indole (indican, 2), (3Z)-hexenyl-(1-O-rhamnopyranosyl-beta-glucopyranoside) (3), (3Z)-hexenyl-1-O-beta-glucopyranoside (4), and (7E)-6,9-dihydromegastigma-7-ene-3 -one-9-O-beta-glucopyranoside (5). On bioassay on the germination of lettuce, compound 1, the aglycone of 1 (1a), and the aglycone of 3 (3a) exhibited growth inhibitory activity, whereas compound 2 and 3 exhibited growth promotive activity. Compounds 1-5 were detected in the leaves of Celosia argentea L. for the first time in this study.
• Structural analyses of glycolipids from edible mushroom by fast atom bombardment mass spectrometry

  A Sawabe; M Morita; S Ouchi; T Okamoto

  ADVANCES IN PLANT GLYCOSIDES, CHEMISTRY AND BIOLOGY ELSEVIER SCIENCE BV 6 346 - 359 1999 [Refereed]
   

  The structures of glycolipids isolated from Hypsizigus marmoreus (Bunashimeji, a mushroom) and Pleurotus citrinopileatus (Nireouma, a mushroom) were determined to be (4E, 8E)-N-2-hydroxyhexadecanoyl-1-O-beta-glucopyranosyl-9-methyl-C-18-sphinga-4,8-dienine (1), phosphodihexose N-(2-hydroxyoctadecanoyl)-4-hydroxy-C-18-(2), phosphodi-hexose N-(2-hydroxyhexadecanoyl)-4-hydroxy-C-18-sphinganine (3), phosphodihexose N-(2-hydroxytetracosanoyl)-4-hydroxy-C-18-sphi (4), and phosphodihexose N-(2-hydroxydocosanoyl)-4-hydroxy-C18-sphinganine (5). In particular, location of the double bonds in the lone-chain base of 1 was clearly determined by the B/E constant linked scan method. The structure of cerebroside having a long-chain base of 9-methyl-C-18-sphinga-4,8-dienine could be determined in general by the presence of characteristic fragment ions of [C-19-sphingadienine + H-H2O]+ at m/z 276 and [C-19-sphingadienine + H](+) at m/z 294, and the fatty acid carbon number could be calculated from the characteristic fragment ion of [ceramide-180](+) ([MH - GlcOH-180](+)) in positive ion mode FAB mass spectrometry. In the structural determination of 2-5, the ions of m/z 421 and 720 in the negative ion made analyses are assigned to be characteristic of phosphodihexose and phytosphingosine containing phosphodihexose, respectively This is a useful methodology for the structural determination of other unstable natural products such as lipids.
• Structural Analyses of a Precursory substance of Bitterness, New Polyisoprenepolyols from a mushroom by Mass Spectrometry

  SAWABE Akiyoshi

  Mushroom Science and Biotechnology 7 (2) 49  1999
• Stuctural Analyses of Glycolipids in Edible Mushroom by FAB/MS

  SAWABE Akiyoshi

  Bull. Inst. Compr. Agr. Sci. Kinki Univ. (7) 37  1999
• Investigation of Glycosides in the Leaves of African ┣DBCelosia argentea(/)-┫DB L.

  SAWABE Akiyoshi

  Bull. Inst. Compr. Agr. Sci. Kinki Univ. (7) 9  1999
• Effects of Acetylenes and Terpenoids from Solidago altissima L. on Seed Germination

  SAWABE Akiyoshi

  J. Jpn. Oil. Chem. Soc. Japan Oil Chemists' Society 48 (2) 139 - 142 1341-8327 1999 [Refereed]
   

  Four kinds of acetylenes and three kinds of terpenoids were isolated from Solidago altissima L. and characterized by MS, ¹H-NMR and ¹³C-NMR spectroscopy as methyl (Z) -decaene-4, 6, 8-triynoate (Z-dehydromatricaria esther, 1), methyl 10- [(Z) -2-methyl-2-butenoyloxy] - (2Z, 8Z) -2, 8-decadiene-4, 6-diyoate (2), (4Z) -2, 4-decadiene-6, 8-diyn-4-olide (Z-dehydromatricaria lactone, 3), (4E) -2, 4-decadiene-6, 8-diyn-4-olide (E-dehydromatricaria lactone, 4), 13E, 7α-acetoxyl kolavenic acid (solidagonic acid, 5), kolavenol (6), and D : C-friedours-7-en-3β-ol (ilexol, 7). Bioassay of these compounds on the germination of lettuce seeds showed that compounds 1, 2, 3, 4, and 5 exhibited growth inhibitory activity, whereas compound 7 did not exhibit the activity.
• 質量分析法によるきのこに含まれる苦味成分前駆体,新規ポリイソプレンポリオールの構造解析

  沢辺 昭義

  日本応用きのこ学会誌 7 (2) 49 - 56 1999 [Refereed]
  
• 57(P17) Structural Analyses of a Precursory Substance of Bitterness, New Polyisoprenepolyols from an Edible Mushroom by Mass Spectrometry

  Sawabe Akiyoshi; Morita Masanori; Kiso Tatsuya; Kishine Hideki; Ohtsubo Yoshikazu; Ouchi Seiji; Okamoto Tadashi

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (40) 335 - 340 1998/08 

  During the course of our search for functional molecules in edible fungi, we have reported the characterization and structural determination of the sphingolipids in Hypsizigus marmoreus (Bunashimeji, a mushroom) by B/E constant linked scan fast atom bombardment (FAB) mass spectrometry, that is, the fatty acid composition, the location of double bonds in the long-chain base (C19-sphingadienine), or the presence of phosphodihexose. In addition to these compounds, we also found many polyisoprenepolyols in a hot water-ethanol extract of an edible mushroom. In the polyisoprenepolyols, gymnopilins were discovered independently by two groups almost at the same time in 1983 (Nozoe et al. and Aoyagi et al.) from Gymnopilus spectabilis (o-waraitake, an hallucinogenic mushroom), as a bitter principle of the mushroom. However, gymnoprenol which has a free terminal hydroxy group instead of half-ester of 3-hydroxy-3-methylglutaric acid, has no bitter taste. Recently, Nozoe and Shirahama reported that these polyisoprenepolyols have an antitumor activity and also excitatory activity in central neurons. In the polyisoprenepolyols isolated from Hypsizigus marmoreus (Bunashimeji), we found new polyisoprenepolyols, which seem to be the precursor of gymnopilins. This compound has a terminal olefinic carbon group instead of a free terminal hydroxy group in gymnoprenol, and we named as hypsiziprenol. In the past, the structures of these polyisoprenepolyols were determined by chemical degradation studies, which require large amounts of sample. Here we describe, how information on the isoprenoid sequence and the number of hydroxy groups present can conveniently be derived by mass spectrometric methods that require only minute amounts of sample.
• Plant Odours and their Chemical Structures

  SAWABE Akiyoshi

  Bull. Inst. Compr. Agr. Sci. Kinki Univ 近畿大学農学総合研究所 (6) 115 - 117 0919-3022 1998 

  [Synopsis] Essential oils obtained from leaves, trunks, stalks, roots, and natural resins of plants, are the source of characteristic odours and consisted of terpenes, aromatic alcohols, aldehydes, ketones, esters, and so on. These compounds are present in cells of plant tissues and are mostly stored as glycosides. As occasion demands, these are discharged as odour in the atmosphere by the function of enzymes. In this manuscript, we have briefly reviewed some studies on odours, focussing on the plant odours and their chemical structures.
• Bioactive Glycosides in Citrus Fruit Peels

  SAWABE Akiyoshi

  Bull. Inst Compr. Agr. Sci. Kinki Univ. 近畿大学農学総合研究所 (6) 57 - 67 0919-3022 1998 

  [Synopsis] Since 1980's we have been investigating bioactive compounds in citrus fruit peels. We have successfully isolated seventy-three glycosides including thirty-four new compounds. They were flavonoid glycosides, phenylpropanoid glycosides, terpenoid glycosides, limonoid glycosides, and alkyl glycosides. The biological activities of the compounds were studied for the utilization as hypotensive and hypertensive drugs. In this manuscript, recent works are briefly reviewed focussing on the isolation and mutual relationships between the structures of the compounds and their biological activities. (摘要） 有用植物資源として、貴重な柑橘類果皮のより高度な利用開発の基礎研究として、著者らは11種の柑橘類果皮中から34種の新規化合物を含む73種の生物活性物質の分離に成功した。これらの化合物の構造と生物活性の相関性について考察した。
• Glycosides in the Leaves of African Celosia Argentea L.

  SAWABE Akiyoshi

  J. Jpn. Oil Chem. Soc. Japan Oil Chemists' Society 47 (1) 25 - 30 1341-8327 1998 [Refereed]
   

  Five glycosides were isolated from the leaves of Celosia argentea L. and their structures were determined based on UV, MS, ¹H-NMR and ¹³C-NMR spectroscopic data as 1- (4-O-β-glucopyranosyl-3-methoxyphenyl) propane-2-ene (citrusin C, 1), 3-O-β-glucopyranosyl-1H-indole (indican, 2), (3Z) -hexenyl-1-O- (6-O-α-rhamnopyranosyl-β-glucopyranoside) (3), (3Z) -hexenyl-1-O-β-glucopyranoside (4), and (7E) -6, 9-dihydromegastigma-7-ene-3-one-9-O-β-glucopyranoside (5). On bioassay on the germination of lettuce, compound 1, aglycone of 1 (1a), and aglycone of 3 (3a) exhibited growth inhibitory activity, whereas compounds 2 and 3 exhibited growth promotive activity. The presence of compounds 1-5 in the leaves of Celosia argentea L. is reported here for the first time.
• Structu Elucidation of Compex Lipids by FAB/MS

  Masanori MORITA; Akiyoshi SAWABE

  Journal of the Mass Spectrometry Society of Japan The Mass Spectrometry Society of Japan 46 (3) 204 - 210 1340-8097 1998 [Refereed]
   

  As a part of our search for functional natural molecules we have been investigating the extract of an edible fungi (bunashimeji). In this manuscript we describe structural elucidation of complex lipids and polyisoprenepolyols isolated from the mushroom bunashimeji by FAB mass spectrometry.
• Characterization of Functional Molecules Isolated from Mushrooms by Mass Spectrometry

  SAWABE Akiyoshi

  Bull. Inst. Compr. Agr. Sci. Kinki Univ. 近畿大学農学総合研究所 (5) 105 - 119 0919-3022 1997 

  [Synopsis] Fast atom bombardment (FAB) mass spectrometry is a powerful tool for analyzing the structure of natural functional molecules. Analyses in the positive and negative ion modes, provide different data. Although some of structural information is available from routine FAB mass spectra, more detailed information is provided by the linked scan spectra. In this communication, reacent advances in this field are briefly reviewed focussing on the structural elucidation of functional molecules isolated from mushrooms by FAB mass spectrometry.澤邊, 昭義
• Characterization of the Z┣D5-┫D5 and E┣D5-┫D5 Isomers of Dehydromatricaria Lactones

  SAWABE Akiyoshi

  J. Jpn. Oil Chem. Soc. Japan Oil Chemists' Society 46 (4) 413 - 417 1341-8327 1997 [Refereed]
   

  Four polyacetylenes including the Z and E isomers of dehydromatricaria lactones were isolated from Solidago altissima L. and characterized. The polyacetylenes could be easily detected as yellowish brown spots on TLC plate following irradiation with blue black light during two to three minutes. The Z and E isomers of dehydromatricaria lactones were easily differentiated based on differences in melting points and chemical shifts of ¹H-and ¹³C-NMR spectroscopy. This study presents the first isolation of (E) -dehydromatricaria lactone from Solidago altissima L. in nature.
• Terpenoid- and Pheny1 Propanoid-Glycosides Isolated from Leaves of Hiba (┣DBThujopsis dolabrata(/)-┫DB SEIB. et ZUCC. )

  Takao OBATA; Akiyoshi SAWABE; Masanori MORITA; Natsuki YAMASHITA; Yoshiharu MATSUBARA

  J. Jpn. Oil Chem. Soc. Japan Oil Chemists' Society 46 (2) 139 - 144 1341-8327 1997 [Refereed]
   

  Three terpenoid glycosides and seven phenyl propanoid glycosides were isolated from the leaves of Hiba (Thujopsis dolabrata SEIB. et ZUCC., Asunaro), and their structures were determined based on UV, MS, ¹H-NMR and ¹³C-NMR spectroscopic data. The structures were vomifoliol 9-O-β-D-glucopyranoside (1), (6R, 7E, 9R) -9-hydroxymegastigma-4, 7-dien-3-one-9-O-β-D- glucopyranoside (2), (2E, 6R) -2, 6-dimethyl-2, 7-octadien-6-ol-1-O-β-D-glucopyranoside (3), coniferin (4), 2, 3-dihydro-2- (4'-α-L- rhamnopyranosyl-3-methoxyphenyl) -3-hydroxymethyl-7-methoxy-5-benzofuran propanol (5), 2, 3- dihydro-2- (4' -β-D-glucopyranosyl-3' -methoxyphenyl) -3-hydoxymethyl-7-methoxy-5-benzofuran propanol (6), 2, 3-dihydro-2- (4' -β-D-glucopyranosyl-3' -methoxyphenyl) -3-hydoxymethyl-7-hydroxy-5-benzofuran propanol (7), 2, 3-dihydro-2- (4' -hydroxy-3' -methoxyphenyl) -3-hydroxymethyl-7-methoxy-5- 3-O-α-rhamnopyranosylpropan benzofuran (8), 2, 3-dihydro-2- (4' -hydroxy -3' -methoxyphenyl) -3- hydroxymethyl-7-hydroxy-5- (3-O-α-rhamnopyranosylpropan) benzofuran (9), and 1- (4-hydroxy-3-methoxyphenyl) -2- {2-hydroxy-4- (3-O-α-rhamnopyranosylpropan) phenoxy} propan-1, 3-diol (10). Compounds 1 and 3 were found to have no effect on the germination of lettuce. Compounds 110 were detected in the leaves of Hiba for the first time in this study.
• 63(P35) STRUCTURAL ANALYSES OF COMPLEX LIPIDS FROM MUSHROOMS BY MASS SPECTROMETRY

  SAWABE Akiyoshi; MORITA Masanori; INABA Kazunari; OUCHI Seiji; OKAMOTO Tadashi

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (38) 373 - 378 1996/09 

  As a part of our search for functional molecules in edible fungi, we report here the characterization and structural determination of complex lipids (1-6) including new type of glycosyl phosphosphingolipids in Hypsizigus marmoreus (Bunashimeji, a mushroom) and Pleurotus citrinopileatus (Nireouma, a mushroom) by B/E constant linked scan fast atom bombardment (FAB) mass spectrometry. The structures of complex lipids were determined to be O-(1,2-di-O-linoleoylglycero-3-phosphoryl)ethanolamine (1), (4E,8E)-N-2-hydroxyhexadecanoyl-1-O-β-glucopyranosyl-9-methyl-C18-sphinga-4,8-dienine (2), phosphodihexose N-(2-hydroxyoctadecanoyl)-4-hydroxy-C18-sphinganine (3), phosphodihexose N-(2-hydroxyhexadecanoyl)-4-hydroxy-C18-sphinganine (4), phosphodihexose N-(2-hydroxytetracosanoyl)-4-hydroxy-C18-sphinganine (5), and phosphodihexose N-(2-hydroxydocosanoyl)-4-hydroxy-C18-sphinganine (6). In particular, location of the double bonds in the long-chain base of 1 and in the fatty acid of 2 were clearly determined by the B/E constant linked scan method. The structure of cerebroside having a long-chain base of 9-methyl-C18-sphinga-4,8-dienine could be determined in general by the presence of characteristic fragment ions of [C19-sphingadienine + H- H_2O]^+ at m/z 276 and [C19-sphingadienine + H]^+ at m/z 294, and the fatty acid carbon number could be calculated from the characteristic fragment ion of [ceramide -180]^+ ([MH - GlcOH - 180]^+) in positive ion mode FAB mass spectrometry. In the structural determination of 3-6, the ions of m/z 421 and 720 in the negative ion mode analyses are assigned to be characteristic of phosphodihexose and phytosphingosine containing phosphodihexose, respectively. This is a useful methodology for the structural determination of other unstable natural products such as lipids.
• Fast atom bombardment mass spectrometry and linked scan analyses at constant B/E in the structural characterization of new polyisoprenepolyols isolated from an edible mushroom (Hypsizigus marmoreus)

  A Sawabe; M Morita; S Ouchi; T Okamoto

  JOURNAL OF MASS SPECTROMETRY JOHN WILEY & SONS LTD 31 (8) 921 - 925 1076-5174 1996/08 [Refereed]
   

  Fast atom bombardment (FAB) mass spectrometry is a powerful tool for analyzing the structure of polyisoprenepolyols. Analyses in the positive and negative ion mode are complementary in that the former provides data on the number of hydroxy groups present while the latter provides data on the isoprenoid sequence. Some of this information is already available from routine FAB mass spectra. More detailed information is contained in the linked scan spectra.
• Terpenoid glycosides in amanatsu (Citrus natsudaidai) and sudachi (C-sudachi) peels

  A Sawabe; T Obata; M Morita; T Minematsu; N Yamashita; Y Matsubara

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 70 (1) 37 - 39 0002-1407 1996/01 [Refereed]
   

  Five terpenoid glycosides were isolated from amanatsu (Citrus natsudaidai) or sudachi (C. sudachi) peels, and their structures were established on the basis oi MS, H-1-, and C-13-NMR spectroscopy, as well as chemical evidence. They were trans-carveol 6-O-beta-D-glucopyranoside (1), (2 E, 6 R) -2, 6-dimethyl-2, 7-octadien-6-ol-1-O-beta-D-glucopyranoside (2), vomifoliol 9-O-P-D-glucopyranoside (3), (6 R, 7 E, 9 R) -9-hydroxymegastigma -4, 7-dien-3-one-9-O-beta-D-glucopyranoside (4), and (4 S, 6 S)-6-O-beta-D-glucopyranosyl-p-menth-1-en-3-one (5). Among these isolated compounds, 5 is a new terpenoid glycoside.
• 甘夏柑(┣DBCitrus natsudaidai(/)-┫DB)およびスダチ(┣DBC.sudachi(/)-┫DB)果皮中のテルペノイド配糖体

  沢辺 昭義

  日本農芸化学会誌 70 (1) 37 - 39 1996/01 [Refereed]
  
• Several Steroids and Phenylpropanoid Glycosides isolated from leaves of Getto(┣DBAlpina speciosa(/)-┫DB K.Schum.)

  SAWABE Akiyoshi

  J.Jpn.Oil Chem.Soc. Japan Oil Chemists' Society 44 (11) 1012 - 1014 0513-398X 1995 [Refereed]
   

  Three steroids and four phenylpropanoid glycosides were isolated from leaves of Getto (Alpinia speciosa K. Sebum), and their structures were determined based on UV, MS, ¹H-NMR, and ¹³C-NMR spectroscopic data.
  The structures were β-sitosterol (1), campesterol (2), stigmasterol (3), coniferin (4), syringin (5), 2, 3-dihydro-2- (4-β-D-glucopyranosyl-3-methoxyphenyl) -3-hydroxymethyl-7-hydroxy-5-benzofranpropanol (6), and citrusin B (7). Compounds 4 and 5 showed no effect for the germination of lettuce.
  All compounds isolated in this study, 17 were found in the leaves of Getto for the first time.
• Structural Analyses of Natural Organic Compounds from Mshrooms by Mdern Mass Spectrometry

  SAWABE Akiyoshi

  Mushroom Science and Biotechnoligy Japanese Society of Mushroom Science and Biotechnology 2 (4) 157 - 166 1340-7767 1995 [Refereed]
   

  odern mass spectrometry has original advantages in that it enables observation of molecular signals even of labile compounds, by means of "soft ionization" techniques such as fast atom bombardment (FAB), and allows characterization of individual molecules present in a mixture with the use of tandem mass spectrometry (MS/MS method) or B/E constant linked scan method. These methods are successfully applied to the determination of natural organic compounds, in particular. In this manuscript, recent works are reviewed focussing on the structural elucidation of lipids including new glycosyl phosphosphingolipids isolated from mushrooms by FAB mass spectrometry.
• B/E constant Linked Scan Fast Atom Bombardment Analysis of a New Type of Glycosy Phosphosphingolipid Isolated from Edible Fungi (Mushroom)

  Akiyoshi SAWABE; Masanori MORITA; Seiji OUCHI; Tadashi OKAMOTO

  Journal of the Mass Spectrometry Society of Japan The Mass Spectrometry Society of Japan 43 (2) 115 - 120 1340-8097 1995 [Refereed]
   

  The structures of new type of glycosyl phosphosphingolipids (1-4) isolated from Hypsizigus marmoreus (Bunashimeji, a mushroom) were determined by B/E constant linked scan fast atom bombardment (FAB) mass spectrometry. Each molecular species has common to a phytosphingosine (4-hydroxy-C₁₈-sphinganine) in the long-chain base, phosphodihexose group, and a fatty acid of the difference of carbon numbers. The alkyl chains of fatty acids are determined to be 2-hydroxyoctadecane, 2-hydroxyhexadecane, 2-hydroxytetracosane, and 2-hydroxydocosane for 1-4, respectively. The ions of m/z 421 and 720 in the negative ion mode analyses are assigned to be characteristic of a phosphodihexose and a phytosphingosine containing phosphodihexose, respectively.
• Structural Analyses of Natural Organic Compounds from Mushroom by Modern Mass Spectrometry

  SAWABE Akiyoshi; MORITA Masanori; INABA Kazunari; OUCHI Seiji; OKAMOTO Tadashi

  Mushroom science and biotechnology Japanese Society of Mushroom Science and Biotechnology 2 (4) 157 - 166 1340-7767 1995 [Refereed]
   

  odern mass spectrometry has original advantages in that it enables observation of molecular signals even of labile compounds, by means of "soft ionization" techniques such as fast atom bombardment (FAB), and allows characterization of individual molecules present in a mixture with the use of tandem mass spectrometry (MS/MS method) or B/E constant linked scan method. These methods are successfully applied to the determination of natural organic compounds, in particular. In this manuscript, recent works are reviewed focussing on the structural elucidation of lipids including new glycosyl phosphosphingolipids isolated from mushrooms by FAB mass spectrometry.
• Several Steroids and Phenylpropanoid Glycosides isolated from Leaves of Getto (Alpinia speciosa K. Schum.)

  OBATA Takao; SAWABE Akiyoshi; MORITA Masanori; YAMASHITA Natsuki; MATSUBARA Yoshiharu

  Journal of Japan Oil Chemists' Society Japan Oil Chemists' Society 44 (11) 1012 - 1014 0513-398X 1995 [Refereed]
   

  Three steroids and four phenylpropanoid glycosides were isolated from leaves of Getto (Alpinia speciosa K. Sebum), and their structures were determined based on UV, MS, ¹H-NMR, and ¹³C-NMR spectroscopic data.
  The structures were β-sitosterol (1), campesterol (2), stigmasterol (3), coniferin (4), syringin (5), 2, 3-dihydro-2- (4-β-D-glucopyranosyl-3-methoxyphenyl) -3-hydroxymethyl-7-hydroxy-5-benzofranpropanol (6), and citrusin B (7). Compounds 4 and 5 showed no effect for the germination of lettuce.
  All compounds isolated in this study, 17 were found in the leaves of Getto for the first time.
• THE LOCATION OF DOUBLE-BONDS IN A CEREBROSIDE FROM EDIBLE FUNGI (MUSHROOM) ESTIMATED BY B/E LINKED SCAN FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY

  A SAWABE; M MORITA; T OKAMOTO; S OUCHI

  BIOLOGICAL MASS SPECTROMETRY JOHN WILEY & SONS LTD 23 (11) 660 - 664 1052-9306 1994/11 [Refereed]
   

  The structure of a cerebroside isolated from Hypsizigus marmoueus (mushroom, Bunashirneji) was determined to be (4E, 8E)-N-2-hydroxyhexadecanoyl-1-O-beta-glucopyranosyl-9-methyl-C-18-sphinga-4,8,-diene (1) by positive and negative ion mode fast atom bombardment (FAB) mass spectrometry using the B/E constant linked scan method. In particular, the location of the double bonds in the long-chain base was determined by the method. The structure of cerebrosides having the long-chain base of 9-methyl-C-18-sphinga-4,8-dienine could be determined in general by the presence of characteristic fragment ions of [C-19-sphingadienine + H - H2O](+) at m/z 276 and [C-19-sphingadienine + H](+) at m/z 294, and the fatty acid carbon number could be calculated from the characteristic fragment ion of [ceramide - 180]+ ([MH - GlcOH - 180]+) in positive ion mode FAB mass spectrometry. Compound 1 was isolated for the first time from Hypsizigus marmoreus in the present study.
• THE SYNTHESIS OF NATURALLY-OCCURRING (-)-CALYCULIN-A

  N TANIMOTO; SW GERRITZ; A SAWABE; T NODA; SA FILLA; S MASAMUNE

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH VCH PUBLISHERS INC 33 (6) 673 - 675 0570-0833 1994/03 [Refereed]
  
• Constituents of Essential Oil in the Leaf and Flower of Getto (Alpinia speciosa K. Schum.)

  MATSUBARA Yoshiharu; MORITA Masanori; KATSUI Akira; SAWABE Akiyoshi

  Journal of Japan Oil Chemists' Society Japan Oil Chemists' Society 43 (5) 424 - 427 0513-398X 1994 [Refereed]
   

  Constituents of essential oil in the leaf and flower of Getto (Alpinia speciosa K. Schum.) were investigated. Their structures were identified by GLC and GC-MS spectroscopy. The characteristic major components were ketones such as namely fenchone (Peak 8), camphor (Peak 9), 4-isopropyl-2-cyclohexene-1-one (Peak 20), 7, 7-dimethylbicyclo [4.1.1] oct-3-one (Peak 21), 7, 7-dimethylbicyclo [4.1.1] oct-2-one (Peak 25), isomer of nezukone (Peak 34), and nezukone (Peak 44). Peaks 21 and 25 could be identified here for the first time from the flower of Getto in nature.
• USE OF 2-TRIMETHYLSILYLETHYL AS A PROTECTING GROUP IN PHOSPHATE MONOESTER SYNTHESIS

  A SAWABE; SA FILLA; S MASAMUNE

  TETRAHEDRON LETTERS PERGAMON-ELSEVIER SCIENCE LTD 33 (50) 7685 - 7686 0040-4039 1992/12 [Refereed]
   

  A model study has demonstrated that phosphorylation of a highly hindered hydroxyl group can be achieved via sequential treatment with (1) 2-trimethylsilylethyl dichlorophosphite, (2) 2-trimethylsilylethyl alcohol, and (3) hydrogen peroxide. The resulting triester survives a variety of reaction conditions but may be cleaved with fluoride ion to afford the phosphate monoester.
• TOWARDS THE SYNTHESIS OF CALYCULIN - A SYNTHETIC INTERMEDIATE CORRESPONDING TO THE C(26)-C(37) FRAGMENT

  HA VACCARO; DE LEVY; A SAWABE; T JAETSCH; S MASAMUNE

  TETRAHEDRON LETTERS PERGAMON-ELSEVIER SCIENCE LTD 33 (15) 1937 - 1940 0040-4039 1992/04 [Refereed]
   

  The synthetic intermediate 2 corresponding to the C(26)-C(37) fragment of calyculin A (1) has been synthesized. Key transformations include the efficient one-pot construction of the oxazole system embedded in 1 without epimerization-alpha [C(30)] to the ring, and the in situ formation of the dimethylamine by opening an N-methyllactam with Meerwein's reagent and trapping the resultant methylamine with formaldehyde.
• Structures and Physiological Activity of Coumarins in Hassaku (┣DBCitrus hassaku(/)-┫DB HORT. ), Zabon(┣DBC. gradis(/)-┫DB OSBECK. ), and Amanatsu(┣DBC. natsudaidai(/)-┫DB)Peels

  SAWABE Akiyoshi

  J. Jpn. Oil Chem. Soc. (YUKAGAKU) Japan Oil Chemists' Society 41 (3) 249 - 251 0513-398X 1992 [Refereed]
   

  Two coumarin derivatives were isolated from hassaku (Citrus hassaku HORT.), zabon (Citrus gradis OSBECK.) and amanatsu (Citrus natsudaidai) peeling. Their structures were determined by means of MS, ¹H-NMR and ¹³C-NMR spectroscopy.
  8- (2, 3-dihydroxy-3-methylbutyl) -7-methoxycoumarin (1) and 7- [(6, 7-dihydroxy-3, 7-dimethy1-2 E-octenyl) oxy] coumarin (2) were found.
  Compound (1) was intravenously injected into SHR-SP rats (1 mg/100 g body weight) with subsequent rise in blood pressure. Compound (2) was not tested owing to its poor solubility in water.
• STUDIES ON PHYSIOLOGICALLY ACTIVE SUBSTANCES IN CITRUS-FRUIT PEEL .21. STRUCTURES OF NEW CYCLIC-PEPTIDES IN YOUNG UNSHIU (CITRUS-UNSHIU MARCOV), ORANGE (CITRUS-SINENSIS OSBECK) AND AMANATSU (CITRUS-NATSUDAIDAI) PEELINGS

  Y MATSUBARA; T YUSA; A SAWABE; Y IIZUKA; S TAKEKUMA; Y YOSHIDA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 55 (12) 2923 - 2929 0002-1369 1991/12 [Refereed]
   

  Four cyclic peptides were isolated from young unshiu (unripe fruit), orange and amanatsu peelings, and their structures were established on the basis of FAB-MS (CID method) and 2D-NMR spectroscopic data, and by chemical evidence. They were each found to consist of seven or eight amino acids. In the present study, compounds 1-4 are shown to be new cyclic Peptides.
• STUDIES ON PHYSIOLOGICALLY ACTIVE SUBSTANCES IN CITRUS-FRUIT PEEL .20. STRUCTURE AND PHYSIOLOGICAL-ACTIVITY OF PHENYL PROPANOID GLYCOSIDES IN LEMON (CITRUS-LIMON BURM F) PEEL

  Y MATSUBARA; T YUSA; A SAWABE; Y IIZUKA; K OKAMOTO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 55 (3) 647 - 650 0002-1369 1991/03 [Refereed]
   

  We report here the difference between phenyl propanoid glycosides obtained from hot water and methanol extracts of lemon peel. Eight phenyl propanoid glycosides were isolated, and their structures were established by UV, MS, H-1-NMR and C-13-NMR spectroscopy, as well as by chemical evidence. They were coniferin (1), syringin (2), dehydrodiconiferyl alcohol-4-beta-glucoside (3), citrusin A (4), citrusin B (5), citrusin C (6), methyl-3-(4-beta-glucopyranosyl-3-methoxyphenyl)propionate (7) and methyl-3-{4-(6-O-alpha-glucopyranosyl-beta-glucopyranosyl)-3-hydroxyphenyl}propionate (8). Compound 7, after intravenously injecting (0.5 mg/100 g of body weight) into stroke-prone spontaneously hypotensive rats (SHR-SP), was found to lower the blood pressure. Among these isolated compounds, 7 and 8 are new phenyl propanoid glycosides.
• STUDIES ON PHYSIOLOGICALLY ACTIVE SUBSTANCES IN CITRUS-FRUIT PEEL .18. STRUCTURES OF NEW LIMONOID GLYCOSIDES IN LEMON (CITRUS-LIMON BURM F) PEELINGS

  Y MATSUBARA; A SAWABE; Y IIZUKA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 54 (5) 1143 - 1148 0002-1369 1990/05 [Refereed]
  
• STRUCTURE AND PHYSIOLOGICAL-ACTIVITY OF PHENYL PROPANOID GLYCOSIDES IN THE LEAF OF HINOKI (CHAMAECYPARIES-OBTUSA SIEB ET ZUCC)

  Y MATSUBARA; T NAKANO; A SAWABE; Y IIZUKA; K OKAMOTO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 54 (2) 557 - 559 0002-1369 1990/02 [Refereed]
  
• STRUCTURE OF TERPENOID GLYCOSIDES IN THE LEAF OF HINOKI (CHAMAECYPARIES-OBTUSA SIEB ET ZUCC)

  Y MATSUBARA; A SAWABE; H IBA; Y IIZUKA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 54 (2) 555 - 556 0002-1369 1990/02 [Refereed]
  
• STRUCTURE AND PHYSIOLOGICAL-ACTIVITY OF NITROGENOUS COMPOUNDS AND ALKYL GLYCOSIDES IN LEMON (CITRUS-LIMON BURM F), UNSHIU (CITRUS-UNSHIU MARCOV), HASSAKU (CITRUS-HASSAKU HORT), YUZU (CITRUS-JUNOS SIEB) AND IYOKAN (CITRUS-IYO) PEELINGS

  Y MATSUBARA; T MIZUNO; A SAWABE; Y IIZUKA; K OKAMOTO

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 63 (8) 1373 - 1377 0002-1407 1989/08 [Refereed]
  
• Structure of steroids in lemon (Citrus limon burm.f.) peelings

  Yoshiharu Matsubara; Akiyoshi Sawabe; Yoshitomi Iizuka

  Agricultural and Biological Chemistry 53 (6) 1115 - 1117 0002-1369 1989 [Refereed]
  
• Structures and Hypotensive Effect of Flavonoid Glycosides in Young ┣DBCitrus unshiu(/)-┫DB Peelings

  SAWABE Akiyoshi

  J. Jpn. Oil Chem. Soc. (YUKAGAKU) Japan Oil Chemists' Society 38 (1) 53 - 59 1884-2003 1989 [Refereed]
   

  As a series of our studies on physiologically active substances in citrus fruit peels, we report here the differences between flavonoid glycosides in Citrus unshiu peelings (the ripe fruit peels) and flavonoid glycosides in young Citrus unshiu peelings (the unripe fruit peels). Eleven flavonoid glycosides were isolated from young Citrus unshiu peels and their structures established by UV, MS, ¹H-NMR and ¹³C-NMR spectroscopy and also by chemical findings. They were limocitrin 3-β-D-glucoside (1). narirutin (4), rutin (5), narcissin (6), hesperidin (7), 3-hydroxy-5, 6, 7, 8, 3', 4'-hexamethoxyflavone 3-β-D-glucoside (8), 6, 8-di-C-glucosylapigenin (11), 3, 8-di-C-glucosylapigenin (12), 3, 7, 4'-trihydroxy-5, 6, 8, 3'-tetramethoxy flavone 3-β-D-glucoside (13), 3, 7, 4'-trihydroxy-5, 6, 8, 3'-tetramethoxyflavone 3-O- {[3-hydroxy-3-methylglutaryl (1→6)] -β-D-glucoside} (14) and limocitrin 3-O- {[3-hydroxy-3-methylglutaryl (1→6)] -β-D-glucoside} (15).
  Five flavonoid glycosides (11) (15) were found not to be present in Citrus unshiu peelings (the ripe fruit peels), but could be isolated from young Citrus unshiu peelings (the unripe fruit peels).
  Thus the kinds and quantity of flavonoid glycosides in ripe fruit peels and those in unripe fruit peels differ greatly. The relationship between their structures and hypotensive activity was determined by injecting the compounds intravenously in SHR-SP.
  Of these compounds, (13), (14), and (15) were identified here for the first time as flavonoid glycosides.
• Structure of Steroids in Lemon (Citrus Limon Burm. f.) Peelings

  Yoshiharu Matsubara; Akiyoshi Sawabe; Yoshitomi Iizuka

  Nippon Nōgeikagaku Kaishi 63 (6) 1115 - 1117 0002-1407 1989 [Refereed]
   

  During the course of our studies on physiologyically active substances in citrus fruit peelings, four steroids were isolated from lemon peels. Their structures were established by MS, 1H-NMR and 13C-NMR spectroscopy. They were β-sitosterol [1], campesterol [2], stigmasterol [3] and 4, 4-dimethylcholest-5-ene-3-β-ol[4]. Among these compounds, [2], [3] and [4] were found in lemon peels for the first time. © 1989, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.
• レモン(┣DBCitrus limon(/)-┫DB BURM. f. ), 温州みかん(┣DBCitrus unshiu(/)-┫DB MARCOV. ), ハッサク(┣DBCitrus hassaku(/)-┫DB HORT. ), ユズ(┣DBCitrus junos(/)-┫DB SIEB. )およびイヨカン(┣DBCitrus iyo(/)-┫DB)果皮中の含窒素化合物およびアルキル配糖体の構造と生理活性

  沢辺 昭義

  日本農芸化学会誌 63 (8) 1373 - 1377 1989 [Refereed]
  
• STRUCTURE OF TERPENOIDS AND TERPENOID GLYCOSIDES IN UNSHIU (CITRUS-UNSHIU MARCOV) AND YOUNG UNSHIU (YOUNG CITRUS-UNSHIU MARCOV) PEELINGS

  A SAWABE; Y MATSUBARA; Y IIZUKA

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 62 (10) 1475 - 1477 0002-1407 1988/10 [Refereed]
  
• THE STRUCTURE AND PHYSIOLOGICAL-ACTIVITY OF PHENYL PROPANOID GLYCOSIDES IN THE LEMON (CITRUS-LIMON-BURUM F), UNSHIU (CITRUS-UNSHIU) AND KINKAN (FORTUNELLA-JAPONICA) PEELINGS

  A SAWABE; Y MATSUBARA; Y IIZUKA; K OKAMOTO

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY JAPAN SOC BIOSCI BIOTECHN AGROCHEM 62 (7) 1067 - 1071 0002-1407 1988/07 [Refereed]
  
• Structures of Monoterpenoid Glyosides in Orange (┣DBCitrus sinensis(/)-┫DB Osbeck. ), Hassaku (┣DBCitrus hassaku(/)-┫DB Hort. )and yuzu (┣DBCitrus junos(/)-┫DB Sier. )Peelings

  SAWABE Akiyoshi

  J. Jpn. Oil Chem. Soc. (YUKAGAKU) Japan Oil Chemists' Society 37 (1) 13 - 18 1884-2003 1988 [Refereed]
   

  During the course of our studies on physiologically active substances in citrus fruit peels, five monoterpenoid glycosides were isolated from orange, hassaku and yuzu peels, and their structures were established by MS, ¹H-NMR and ¹³C-NMR spectroscopy, and chemical evidences:namely trans-carveol 6-β-D-glucopyranoside[1], α-terpineol 8-β-D-glucopyranoside[2], (2E, 6R)-2, 6-dimethyl-2, 7-octadien-6-ol-1-O-β-D-glucopyranoside(9-hydroxylinalool 9-β-glucopyranoside) [3], vomifoliol 9-O-β-glucopyranoside [4] and (6R, 7E, 9R)-9-hydroxymegastigma-4, 7-dien-3-one-9-O-β-D-glucoside[5].
  Among these [1 ] and [2] are new monoterpenoid glycosides, whereas [3], [4] and [5] were isolated from orange, hassaku and yuzu peels, respectively for the first time.
• The Structure and Physiological Activity of Phenyl Propanoid Glycosides in the Lemon (Citrus Limon Burum F.), Unshiu (Citrus Unshiu) and Kinkan (Fortunella Japonica) Peelings

  Akiyoshi Sawabe; Yoshiharu Matsubara; Yoshitomi Iizuka; Kozo Okamoto

  Nippon Nōgeikagaku Kaishi 62 (7) 1067 - 1071 0002-1407 1988 [Refereed]
   

  During the course of our studies on physiologically active substances in citrus fruit peels, seven phenyl propanoid glycosides were isolated from the lemon, unshiu and kinkan peels, and their structures were determined by MS, 1H-NMR and 13C-NMR spectroscopy, and chemical evidence. Their glycosides were coniferin [1], syringin [2], dehydrodiconiferyl alcohol-4-β-glucoside [3], citrusin A [4], citrusin B [5], citrusin C [6] and 3-(4-hydroxy-3-methoxyphenyl)-l-glucosyl-2-propene [7]. We propose the term citrusin D for the new phenyl propanoid glycoside [7]. Each component was intravenously injected to SHR-SP rats (1 mg/100 g body weight), and compounds [1] and [2] were found to raise blood pressure, but compounds [3], [4], [6] and [7] lowered blood pressure. Among these isolated compounds, [1]~[6] were found in the lemon, unshiu and kinkan peelings for the first time. © 1988, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.
• 98(PB3-9) Structures of Physiologically Active Substances and their Physiological Activity in eleven Citrus Fruit Peelings

  Matsubara Y.; Sawabe A.; Takekuma S.; Iizuka Y.; Kumamoto H.

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (29) 745 - 752 1987/07 

  During the course of our studies on physiologically active substances in citrus fruit peels, 27 compounds (phenyl propanoid glycosides, terpenoid glycosides, limonoid glycosides and adenosin) were isolated from lemon, unshiu, grapefruit, kinkan, sudachi, yuzu, hassaku, zabon, orange, iyokan and amanatsukan peels. On investigating phenyl propanoid glycosides which are expected to have seful physiological activity from a structural view point, we isolated 7 compounds including 4 new glycosides, providing interesting information with regard to physiological activity. As for terpenoids, 7 terpenoids and 7 terpenoid glycosides were isolated and their structures and bioassay were investigated. We also isolated 5 limonoid glycosides. Interestingly, we found in several citrus fruit peels, in the presence of adenosin, which exhibited the strongest hypotensive effect. Among these 27 compounds isolated, 13 are hitherto unreported compounds and the rest have been isolated from citrus fruit peels for the first time.
• STRUCTURE AND PHYSIOLOGICAL-ACTIVITY OF PHENYL PROPANOID GLYCOSIDES OF HASSAKU (CITRUS-HASSAKU HORT) AND ORANGE (CITRUS-SINENSIS OSBECK) PEELINGS

  A SAWABE; Y MATSUBARA; H KUMAMOTO; Y IIZUKA; K OKAMOTO

  JOURNAL OF THE AGRICULTURAL CHEMICAL SOCIETY OF JAPAN AGR CHEM SOC JAPAN 60 (8) 593 - 599 0002-1407 1986 [Refereed]
  
• Structure and Physiological Activity of Phenyl Propanoid Glycosides of Hassaku (Citrus hassaku HORT.) and Orange (Citrus sinensis OSBECK.) Peelings

  Akiyoshi Sawabe; Matsubara Yoshiharu; Hiroyasu Kumamoto; Yoshitomi Iizuka; Kozo Okamoto

  Nippon Nogeikagaku Kaishi 60 (8) 593 - 599 0002-1407 1986 [Refereed]
   

  The structure and hypotensive effect of phenyl propanoid glycosides in hassaku and orange peels are described in a series of studies of physiologically active substances in citrus peels. Six phenyl propanoid glycosides were isolated, and their structures were established: coniferin[l], syringin[2], dehydrodiconiferyl alcohol-4-α-glucoside[3], 1-(4-glucosyl-3-methoxyphenyl)-2-{2-methoxy-4-[1-(E)-propene-3-ol]-phenoxy}-propane-1, 3-diol[4], i-(4-glucosyl-3-methoxyphenyl)-2-{2,6-dimethoxy-4-[1-(E)-propene-3-ol]-phenoxy}-propane-1,3-diol [5] and 1-(4-glucosyl-3-methoxyphenyl)-propane-2-ene [6] by MS, UV, 1H-NMR and 13C-NMR spectroscopy and chemical evidence. We propose the terms citrusin A, B and C for these new phenyl propanoid glycosides([4], [5] and [6]). Each component was intravenously injected in SHR-SP rats (1mg/100g body weight), and compounds [1] and [2] were found to raise rat blood pressure, but compounds [3], [4] and [6] lower rat blood pressure. © 1986, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.
• 92 Structure and Hypotensive Effect of Flavonoid Glycosides in Citrus Fruits Peels

  Matsubara Y.; Kumamoto H.; Sawabe A.; Iizuka Y.; Okamoto K.

  Symposium on the Chemistry of Natural Products, symposium papers Symposium on the chemistry of natural products (27) 702 - 709 1985/09 

  A search was made to isolate hypotensive substances from the hot water extract of citrus fruits peels. The forty-four flavonoid glycosides were isolated by repeating chromatography and by gel filtration after extracting with butanol and treating with lead subacetate. Their structures were established by MS, UV, ^1H-NMR and ^<13>C-NMR spectroscopy and the sugar analysis. Among these compounds, the nineteen flavonoid glycosides were new. Each component was intravenously injected in SHR-SP(0.3〜1mg/100g of body weight), and many compounds were found to lower the rat blood pressure. In especial, hypotensive effect of 6,8-di-C-glucosylapigenin showed the effect very strongly.
• Structures and Physiological Activity of Phenyl Propanoid Glycosides in Lemon, Unshiu, and Orange Peelings

  SAWABE Akiyoshi

  Medical Journal of Kinki University 10 (4) 51  1985
• Structures of Limonoid Glycosides Lemon and Unshiu Peelings

  SAWABE Akiyoshi

  Medical Journal of Kinki University 10 (4) 59  1985

Books etc

• クワンソウ由来ヒプノカリス®含有食品の睡眠改善効果，「眠りの科学とスリープテック」

  澤邊昭義; 竹田竜嗣 (Joint work)バイオテクノロジーシリーズ （108頁～113頁），シーエムシー出版（ISBN978-4-7813-1727-4） 2023/03
• NMNの秘密

  インタビュー; 澤邊昭義 (Others)栄養書庫，株式会社ニュートリエントライブラリー 2022/11 9784910307299
• Anti-aging effect of the constituent included in three kinds of spice seeds, "Functions and Applications of Spices and Herbs"

  Akiyoshi Sawabe (Single work)食品シリーズ （289頁～298頁）、シーエムシー出版（ISBN978-4-7813-1521-8） 2020/10
• Glucoside synthesis and functionality as the cosmetics material using the chlorogenic acid metabolite derived from a plant, "Synthesis and Application of a Functional Glcoside"

  Akiyoshi Sawabe; Masato Nomura (Joint work)バイオテクノロジーシリーズ （185頁～194頁）、シーエムシー出版 2013/06 9784781308029 

  植物由来のクロロゲン酸代謝物を用いて化粧品素材としての配糖体合成とその機能性について、これまでの実験結果を論文にしたデータをまとめたものである。
• Proceedings of First AFSSA Conference on Food Safety and Food Security, GEO-REX RAPID ANALYSIS ASSESSMENT OF HEAVY METALS IN RICE, PADDY-RICE, AND SOILS.

  澤邊 昭義; 仲川 一彰; 竹田 竜嗣; 飯田 彰; 米虫 節夫; 玉木 聡史; 岩佐; 航一 (Joint work)Asian Food Safety and Security Association 2013/01
• Proceedings of the 4th European Conference on Chemistry for Life Science, Food additives or Cosmetic ingredients in Plygonum cuspidatum

  澤邊 昭義; 中村 貴俊; 藤井 善之; 竹田 竜嗣; 飯田 彰 (Joint work)Medimond s.r.l. 2011/12
• 環境毒性学

  澤邊 昭義 (Joint work)朝倉書店 2011/03 9784254400205
• 身近に学ぶ化学の世界

  澤邊 昭義 (Joint work)共立出版 2009/10
• Contaminated soils, Sediments and Water: Science in the Real World, Vol. 11, Accumulation of Heavy Metals by Cucumber and Brassica juncea Under Different Cultivation Conditions.

  澤邊 昭義; 竹田 竜嗣; 佐藤 有希子; 吉村 留美; 米虫 節夫 (Joint work)Springer, USA 2006/11 0978764005 

  重金属集積機構の解明の一助として、無毒化に関与する物質を探索した。実験では水耕栽培にて重金属の鉛を曝露させたキュウリ(Cucumis sativus)とカボチャ(Cucurbita maxima)を用いて、①鉛集積量、元素濃度の分析(原子吸光分光光度計)、②グルタチオンの測定(蛍光強度計およびHPLC)、③アミノ酸の分析(GC-MS)を行った。（英文）
• Contaminated soils, Sediments and Water: Science in the Real World, Vol. 11, Field investigation of PAHs in Soils around Nara City in Japan

  SAWABE Akiyoshi (Joint work)Springer, USA, 2006
• Contaminated soils, Sediments and Water: Science in the Real World, vol. 9, Accumulation of Heavy Metals by Japanese Weeds and their Seasonal Movement

  SAWABE Akiyoshi (Joint work)Springer, USA 2004/11 038723036X
• 植物を利用した有用物質の生産 −1. 工業原料の生産と利用 −;新農業環境工学−21世紀のパースペクティブ−；日本生物環境調節学会編

  松田克礼; 沢辺昭義; 野々村照雄; 豊田秀吉 (Joint work)養賢堂発行 2004 4842503599
• Accumulation of Heavy Metals by Japanese Weeds and their Seasonal Movement; Contaminated soils, Sediments and Water: Science in the Real World

  Springer 2004
• Hypotensive and hypertensive compounds from citrus fruit peels

  Research Advances in Agricultural & Food Chemistry 2000
• Research Advances in Agricultural & Food Chemistry, Hypotensive and hypertensive compounds from citrus fruit peels

  SAWABE Akiyoshi (Hypotensive and hypertensive compounds from citrus fruit peels)2000
• Structural Analyses of Glycolipids from Edible Mushroom by Fast Atom Bombardment Mass Spectrometry

  Advances in Plant Glycosides, Chemistry and Biology Elsevier, Amsterdam 1999
• Investigation of Functional Molecules in African ┣DBCelosia argentea(/)-┫DB L.

  Advances in Plant Glysocides, Chemistry and Biology Elsevier, Amsterdam 1999
• Bioactive Glysosides in Citrus Fruit Peels

  Advances in Plant Glycosides, Chemistry and Biology Elsevier, Amsterdam 1999
• Advances in Plant Glycosides, Chemistry and Biology, Structural Analyses of Glycolipids from Edible Mushroom by Fast Atom Bombardment Mass Spectrometry

  SAWABE Akiyoshi (Joint work)Elsevier Science 1999
• Advances in Plant Glycosides, Chemistry and Biology, Investigation of Functional Molecules in African Celosia argentea L.

  SAWABE Akiyoshi (Joint work)Elsevier Science 1999
• Advances in Plant Glycosides, Chemistry and Biology, Bioactive Glycosides in Citrus Fruit Peels

  SAWABE Akiyoshi (Joint work)Elsevier Science 1999
• Structure-function relationship of bioactive compounds in citrus fruit peels

  Recent Research Developments in Agricultural & Biological Chemistry Research Signpost, India 1998
• Recent Research Developments in Agricultural & Biological Chemistry, Vol. 2, Structure-function relationship of bioactive compounds in citrus fruit peels

  SAWABE Akiyoshi (Joint work)Research Signpost, India 1998 8186481656

Conference Activities & Talks

• 摘果柿に含まれる機能性成分の有効利用 ―エマルションを用いた高齢者用食品の風味の劣化抑制効果―  [Not invited]

  澤邊 昭義; 吉岡 佐知子

  第64回香料・テルペンおよび精油化学に関する討論会  2020/10
• ナツメジュースに含まれる機能性成分の探索  [Not invited]

  澤邊 昭義; 田中 文人

  第64回香料・テルペンおよび精油化学に関する討論会  2020/10
• 高麗人蔘のアンチエイジング効果  [Not invited]

  澤邊 昭義

  第74回日本栄養・食糧学会大会  2020/05
• Effect on skin aging of functional compounds included in Coriandrum sativum. L seed  [Not invited]

  Akiyoshi Sawabe

  The 2020 Annual Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry  2020/03
• AGEs inhibitor in immature persimmon “Tekka-kaki”  [Not invited]

  SAWABE Akiyoshi; Ohnishi Natsumi

  The 12th International Conference and Exhibition  2019/12
• The effects of components from wine on corneal damage and inflammation  [Not invited]

  SAWABE Akiyoshi; Yamamoto Akifumi

  American Society for Enology and Viticulture, Japan Chapter, 2019 Kofu  2019/11
• Anti-aging Effects of Constituents in Merlot Wine Compression Residue  [Not invited]

  SAWABE Akiyoshi; Ohnishi Natsumi

  American Society for Enology and Viticulture, Japan Chapter, 2019 Kofu  2019/11
• Effect on skin aging of constituents included in Coriandrum sativum.L seed  [Not invited]

  SAWABE Akiyoshi

  The 63rd Symposium on the Chemistry of Terpenes, Essential Oils and Aromatics  2019/09
• Constituents in wine or wine compression residue alleviates aging of skin  [Not invited]

  SAWABE Akiyoshi

  10th International Workshop on Anthocyanins (IWA 2019)  2019/09
• Utilization of the functional ingredient includedin immature persimmon "Tekka-kaki"  [Not invited]

  SAWABE Akiyoshi; Ohnishi Natsumi

  The 66th Conference on the Japanese Society for Food Science and Technology  2019/08
• Properties of Shikwasa (Citrus depressa) juice to improve lipid metabolism  [Not invited]

  SAWABE Akiyoshi; TAKEDA Ryuji

  Fall 2018 ACS National Meeting & Expo  2018/08
• Discoloration preventive agents of food and anti-aging effects of the constituents in the seed of Foeniculum vulgare  [Not invited]

  SAWABE Akiyoshi; YAMASHITA Atsuyuki

  Fall 2018 ACS National Meeting & Expo  2018/08
• Anti-aging effects of the constituents in the leaves of Callicarpa dichotoma  [Not invited]

  SAWABE Akiyoshi

  Fall 2018 ACS National Meeting & Expo  2018/08
• 脂質ハイドロゾルの安定性に及ぼす流動特性の影響  [Not invited]

  沢辺 昭義; 渡邉 義之; 菅野憲一; 野村正人

  日本農芸化学会2018年度大会  2018/03
• Effects of wine components on corneal damage  [Not invited]

  SAWABE Akiyoshi

  The American Society for Enology and Viticulture, Japan Chapter  2017/11
• Anti-aging effects of wine polyphenols and the utilization of wine compression residue  [Not invited]

  SAWABE Akiyoshi

  ICPH 2017 (The 8th International Conference on Polyphenols and Health)  2017/10
• Anti-allergic effects in spice polyphenols, the seed of Coriandrum sativum L. and Cardamoum  [Not invited]

  SAWABE Akiyoshi; YAMASHITA Atsuyuki

  ICPH 2017 (The 8th International Conference on Polyphenols and Health),  2017/10
• Anti-aging effects of the constituents in the seeds of Elettaria cardamomum.  [Not invited]

  SAWABE Akiyoshi; YAMASHITA Atsuyuki

  TEAC2017  2017/09
• Anti-aging effects in Panax ginseng.  [Not invited]

  SAWABE Akiyoshi

  TEAC2017  2017/09
• Evaluation of RAR binding activity materials in Azolla to inhabit the reservoir of Nara City in Japan with yeast two hybrid assay  [Not invited]

  SAWABE Akiyoshi

  The 5th International EcoSummit Congress, EcoSummit 2016  2016/08
• Evaluation of the alpha-glucosidase inhibitory activity of flavanone glycosides and flavones containing C-C bound saccharide in Citrus fruit peels  [Not invited]

  SAWABE Akiyoshi

  The 18th IUFoS –World Congress of Food Science and Technology  2016/08
• Search for Anti-glycation Substances in Pinot Noir Wine Compression Residue  [Not invited]

  SAWABE Akiyoshi

  American Society for Enology and Viticulture, Japan Chapter  2014/08
• Evaluation of RAR binding activity materials in Azolla with yeast two hybrid assay  [Not invited]

  SAWABE Akiyoshi

  4th International Conference on Environmental Pollution and Remediation  2014/08
• ワイン成分のアンチエイジング効果とワイン残渣の有効利用について  [Invited]

  沢辺 昭義

  セミナー“化学千一夜”「あすの夢を語ろう」  2014/06
• RAR agonistic active compound in Azolla  [Not invited]

  SAWABE Akiyoshi

  23d Symposium on Environmental Chemistry  2014/05
• New efficacy of cosmetics material made of grape sap, leaves, and stems  [Not invited]

  SAWABE Akiyoshi

  American Society for Enology and Viticulture, Japan Chapter  2013/11
• Rapid analysis assessment of heavy metals  [Not invited]

  SAWABE Akiyoshi

  4th International Conference and Exhibition on Analytical & Bioanalytical Techniques  2013/10
• Evaluation of the alpha-glucosidase inhibitory activity of flavonoids in the peelings of Citrus Dekopon [(Citrus unshiu × C. Sinensis) × C. Reticulata]  [Not invited]

  SAWABE Akiyoshi; KAWABATA Hiromi

  4th International Conference and Exhibition on Analytical & Bioanalytical Techniques  2013/10
• Evaluation of RAR binding activity materials in plantwith Yeast Two Hybrid Assay  [Not invited]

  SAWABE Akiyoshi; MUKAI Syouko

  4th International Conference and Exhibition on Analytical & Bioanalytical Techniques  2013/10
• Antiinflammatory evaluation of proanthocyanidins in Litchi chinensis seeds  [Not invited]

  SAWABE Akiyoshi

  7th International Workshop on Anthocyanins  2013/09
• マタタビ果実に含まれる成分の抗糖化作用評価  [Not invited]

  沢辺 昭義

  日本食品科学工学会 第60回記念大会  2013/08
• Heavy metal accumulation of Abelmoschus esculentus hairy root  [Not invited]

  SAWABE Akiyoshi

  22nd Symposium on Environmental Chemistry  2013/07
• Search of anti-glycation substances in Wine Compression Residue  [Not invited]

  SAWABE Akiyoshi; KAWAMURA Haruki

  American Society for Enology and Viticulture, Japan Chapter  2012/11
• ワイン圧搾残渣含有成分の動脈硬化抑制作用  [Not invited]

  沢辺 昭義; 川村 晴希

  日本油化学会フレッシュマンサミット OSAKA 2012  2012/11
• デコポン果皮に含まれるα‐グルコシダーゼ阻害活性物質の探索  [Not invited]

  沢辺 昭義; 川端 博美

  日本油化学会フレッシュマンサミットOSAKA2012  2012/11
• Heavy Metal Accumulation of Phytolacca americana Hairy Root  [Not invited]

  SAWABE Akiyoshi

  NERM 2012 American Chemical Society 38th Northeast Regional Meeting  2012/10
• EVALUATION OF ATHEROSCLEROSIS INHIBITORY EFFECT ON POLYPHENOLS IN WINE COMPRESSION RESIDUE  [Not invited]

  SAWABE Akiyoshi; KAWAMURA Haruki

  NERM 2012 American Chemical Society 38th Northeast Regional Meeting  2012/10
• Geo-REX rapid analysis assessment of heavy metals in rice, paddy-rice, and soils  [Not invited]

  SAWABE Akiyoshi

  1st AFSA Conferences on Food Safety and Food Security  2012/09
• ワイン残渣の利用について  [Invited]

  沢辺 昭義

  ASEV日本ブドウ・ワイン学会西日本地域研究会 第6回研究集会  2012/07
• A search for the compounds like an endocrine disrupter in a plant with yeast Two-Hybrid Assay method. II.  [Not invited]

  SAWABE Akiyoshi

  21st Symposium on Environmental Chemistry  2012/07
• Aroma constituent production by the use of clonal technology  [Invited]

  SAWABE Akiyoshi

  Conference of Nippon Koryo Kyokai  2011/01  Tokyo at January 26, 2011 and Osaka at January 28, 2011  Nippon Koryo Kyokai
  
• 重金属暴露が植物細胞に与える影響  [Not invited]

  山田 亮; 澤邊 昭義; 米虫 節夫; 竹田 竜嗣

  2004年度（第100回）日本土壌肥料学会関西支部講演会  2004/12  京都  2004年度（第100回）日本土壌肥料学会関西支部講演会
   

  ファイトレメディエーションは近年の研究によって，様々な植物種を用いて数多くの元素に対する土壌修復法が報告されている。我々はアブラナ科植物の重金属集積能力に注目し，これを用いた作用機構の解明を目指している。本研究で用いたセイヨウカラシナ(Brassica juncea) はCd耐性を持つことで知られていたが，Pb集積においても興味ある知見を得た。
• クチナシ由来のカロテノイドなどの化粧品有用性評価について  [Not invited]

  相沢 亮介; 澤邊 昭義; 米虫 節夫; 石河 千紘; 高橋 一弘; 口; 隆司; 山村 明子

  第18回カロテノイド研究談話会  2004/09  神戸  第18回カロテノイド研究談話会
   

  クチナシに含まれる成分を抽出・単離し，それらの構造を明確にした。得られた成分の光・温度・pH耐性テストを行うとともにチロシナーゼ活性阻害試験および活性酸素抑制試験により化粧品有用性について検討した。
• ブナシメジの苦味成分に対するアミノ酸の影響（その２）  [Not invited]

  吉邑 典承; 澤邊 昭義; 米虫 節夫; 松本 貞義; 寺下 隆夫; 坂下 卓; 松永 基; 堀内 まゆ子; 木村

  日本きのこ学会第８回大会  2004/09  奈良  日本きのこ学会第８回大会
   

  アミノ酸２０種類を１種ずつ添加した培地条件の異なるブナシメジの苦味成分について検討した結果，ある種のアミノ酸を添加すると苦味成分が増加することを見出した。これらの知見に基づき，今後，生産過程における苦味成分の生成機構に関与する酵素を特定できると考える。
• A New Carotenoid Glycoside Isolated from a Marine Microorganism, Strain T-1: Structural Determination and Cultural Characteristic  [Not invited]

  金野 弘和; 澤邊 昭義; 米虫 節夫; 松本 貞義; 藤田 藤樹夫; 岸本 憲明; 住谷 保治; 津島 己幸; 榊 秀之; 幹 渉

  2004 International Congress on Natural Products  2004/08  Phoenix, Arizona, USA  2004 International Congress on Natural Products
   

  鹿児島県種子島海域からダイビングにより採取した微生物は，Fusarium sp. であり，培養によりオレンジ色の色素を生産した。我々は，その色素を分析した結果，新規カロテノイド配糖体化合物として Neurosporaxantin β-D-glucopyranoside を発見した。また，T-1株のカロテノイド生合成経路について検討した結果，lycopeneの存在が確認されたことから，neurosporeneからlycopeneを通りγ-caroteneへ合成される経路があることが推定されることがわかった。
• 重金属暴露が植物細胞に与える影響－ファイトレメディエーションへの応用  [Not invited]

  竹田 竜嗣; 澤邊 昭義; 米虫 節夫; 松本 貞義; 山田 亮; 蜂谷 健; 日置 和也; 福岡 勘介

  第13回環境化学討論会  2004/07  静岡  第13回環境化学討論会
   

  ファイトレメディエーションは近年の研究によって，様々な植物種を用いて数多くの元素に対する土壌修復法が報告されている。我々はアブラナ科植物の重金属集積能力に注目し，これを用いた作用機構の解明を目指している。本研究で用いたセイヨウカラシナ(Brassica juncea) はCd耐性を持つことで知られていたが，Pb集積においても興味ある知見を得た。
• 奈良市周辺の土壌中のPAHsの挙動と暴露源について  [Not invited]

  幾馬 功昌; 澤邊 昭義; 米虫 節夫; 松本 貞義; 竹田 竜嗣

  第13回環境化学討論会  2004/07  静岡  第13回環境化学討論会
   

  奈良市近郊の立地環境の異なる地点から土壌を採取し，多環芳香族炭化水素類（PAHs）の季節変動による挙動を調査した。その結果，物質循環において興味ある知見を得た。
• 奈良市近郊のおける土壌中の多環芳香族炭化水素類（PAHs）の動態調査  [Not invited]

  竹田 竜嗣; 澤邊 昭義; 米虫 節夫; 松本 貞義; 幾馬 功昌; 相沢 亮介

  第65回分析化学討論会  2004/05  沖縄  第65回分析化学討論会
   

  奈良市近郊の立地環境の異なる地点から土壌を採取し，多環芳香族炭化水素類（PAHs）の季節変動による挙動を調査した。その結果，物質循環において興味ある知見を得た。
• クチナシの化粧品有用性評価について  [Not invited]

  相沢 亮介; 澤邊 昭義; 米虫 節夫; 松本 貞義; 石河 千紘; 高橋一弘; 山口隆司; 山村明子

  2004年度日本農芸化学会大会  2004/04  広島  2004年度日本農芸化学会大会
   

  クチナシに含まれる色素，そのほかの成分を抽出・単離し，得られた成分の光・温度・pH耐性テストを行うとともにチロシナーゼ活性阻害試験および活性酸素抑制試験により化粧品有用性について検討した。
• Microbial conversion from linoleic acid to optical active lactone and their antimicrobial activity  [Not invited]

  岸本 憲明; 藤田 藤樹夫; 吉岡 佐知子; 澤邊 昭義; 米虫節夫

  日本防菌防黴学会第30回年次大会  2003/05  大阪  日本防菌防黴学会第30回年次大会
   

  乳酸菌を用いてリノール酸をヒドロキシ脂肪酸に、ついでパン酵母を用いてγラクトンに変換できる条件を確立した。得られた側鎖の長さやラクトン環の大きさ、光学活性の異なるラクトン類について抗菌活性を明らかにした。

Works

• 有用植物資源中の機能性物質の探索

  1997 -1998
• Ivestigation of functional molecules in useful plant resources

  1997 -1998
• Scientific evaluation of the anti-aging effect of unused plant resources

  SAWABE Akiyoshi Others

MISC

• NMNの秘密

  インタビュー; 澤邊昭義  ニュートリエントライブラリー  1  -28  2022/11
• メルローワインおよびその残渣のポリフェノール類のアンチエイジング効果

  田中 文人; 澤邊 昭義; 山盛 拓馬; 竹田 竜嗣; 岸本 賢治  日本栄養・食糧学会大会講演要旨集  75回-  83  -83  2021/07
• クエン酸およびもろみ酢含有飲料の精神的ストレス緩和作用の検証 ランダム化二重盲検プラセボ対照並行群間試験

  又吉 壮輝; 照屋 潤二郎; 照屋 隆司; 山下 敦之; 澤邉 昭義; 近藤 澄夫; 津吉 哲士; 竹田 竜嗣  薬理と治療  48-  (7)  1241  -1249  2020/07
• クワンソウ由来オキシピナタニンの摂取が睡眠の質改善に及ぼす効果 ランダム化二重盲検プラセボ対照比較試験

  竹田 竜嗣; 山下 敦之; 澤邊 昭義; 照屋 潤二郎; 荻堂 裕; 又吉 壮輝; 渡嘉敷 哲; 玉城 研太朗  薬理と治療  48-  (7)  1251  -1258  2020/07
• 高麗人蔘のアンチエイジング効果

  澤邊 昭義; 山下 敦之; 山中 咲樂; 藤平 峻弘; 竹田 竜嗣; 藤田 佳孝  日本栄養・食糧学会大会講演要旨集  74回-  182  -182  2020/04
• Properties of Shikwasa (Citrus depressa) juice to improve lipid metabolism

  Takeda Ryuji; Matayoshi Masaki; Sawabe Akiyoshi  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  256-  2018/08  [Refereed]
  
• Anti-aging effects of the constituents in the leaves of Callicarpa dichotoma

  Sawabe Akiyoshi; Tagashira Shiho; Yamashita Atsuyuki; Takeda Ryuji; Iida Akira  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY  256-  2018/08  [Refereed]
  
• MagnololおよびHonokiol配糖体の美肌効果に関する研究

  澤邊 昭義; 山下 敦之; 竹田 竜嗣; 井上 俊夫; 石井 まや; 谷本 真一; 横野 一歩; 岡田 芳治; 野村 正人  日本栄養・食糧学会大会講演要旨集  71回-  357  -357  2017/04
• Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition

  Osamu Sakai; Toshinori Yasuzawa; Yoshie Sumikawa; Takashi Ueta; Hirotaka Imai; Akiyoshi Sawabe; Shigeru Ueshima  Pathophysiology  24-  (1)  9  -15  2017/03  [Refereed]
  
• Search of AGEs (Advanced Glycation and Products) Generation Inhibitor in Merlot Wine

  沢辺昭義; 山下敦之; 岡本和浩; 竹田竜嗣; 飯田彰; 米虫節夫  日本ブドウ・ワイン学会誌  27-  (2)  62‐63  2016/11
• 酵母Two Hybrid Assayを用いた奈良近郊の溜め池に生息するアゾラに含まれるRAR結合活性物質の評価

  澤邊昭義; 向井渉子; 笹井勝章; 中島大介; 白石不二雄; 竹田竜嗣; 飯田彰  環境化学討論会要旨集(CD-ROM)  25th-  ROMBUNNO.P‐074  2016/06
• ワイン成分のアンチエイジング効果とワイン圧搾残渣の有効利用

  沢辺昭義; 川村晴希; 吉田裕一; 竹田竜嗣; 飯田彰; 濱原典正; 米虫節夫; 川上浩平; 頓宮美樹; 山田高也  日本農芸化学会大会講演要旨集(Web)  2016-  3B019 (WEB ONLY)  2016/03
• Search for Anti-glycation Substances in Black Queen Wine

  沢辺昭義; 足立亜里寿; 竹田竜嗣; 飯田彰; 米虫節夫  日本ブドウ・ワイン学会誌  26-  (2)  84  -85  2015/11
• ブドウ由来ポリフェノール類の動脈硬化抑制作用

  澤邊昭義; 川村春希; 竹田竜嗣; 山田高也; 頓宮美樹; 川上浩平; 飯田彰; 濱原典正; 米虫節夫  香料・テルペンおよび精油化学に関する討論会講演要旨集  59th-  170  -172  2015/09
• 機能性表示のための研究レビューの進め方

  澤邊 昭義  食品と開発  50-  (8)  66  -69  2015/08
• 汚染土壌の汚染源調査と民間側としての対処について

  澤邊昭義; 木下卓耶; 竹田竜嗣; 飯田彰  環境化学討論会要旨集(CD-ROM)  24th-  ROMBUNNO.P‐161  2015/06
• 被験者に「適正・定時・適量」使用を促すコツ

  沢辺 昭義  Cosmetic Stage  9-  (6)  27  -30  2015/06
• Search for anti-glycation substances in Pinot Noir wine compression residue

  沢辺昭義; 吉田裕一; 藤山翔一朗; 竹田竜嗣; 飯田彰; 濱原典正; 米虫節夫  日本ブドウ・ワイン学会誌  25-  (2)  79  -80  2014/08
• 統計学の視点から見た化粧品有用性評価と取っておきたいデータ

  澤邊 昭義  Cosmetic Stage  8-  (6)  10  -14  2014/08
• アゾラのRAR結合活性物質

  澤邊昭義; 向井渉子; 松山大樹; 中島大介; 白石不二雄; 竹田竜嗣; 飯田彰  環境化学討論会要旨集(CD-ROM)  23rd-  ROMBUNNO.3B-06  2014/05
• ワインやブドウに含まれる成分が肌の老化を抑える

  沢辺昭義; 川端博美; 向井渉子; 竹田竜嗣; 飯田彰; 米虫節夫  日本ブドウ・ワイン学会誌  24-  (2)  87  -88  2013/11
• オクラ毛状根の重金属吸収能力測定

  澤邊昭義; 高田峻輔; 山口秀典; 徳田浩一郎; 竹田竜嗣; 飯田彰  環境化学討論会要旨集(CD-ROM)  22nd-  ROMBUNNO.1PB-16  2013/07
• Effect of postcibal blood triglyceride level and blood glucose level by single intake of calcium alginate content food for adult men

  澤邊 昭義; 福田 靖; 上野 昌樹  食生活研究  33-  (2)  41  -46  2013
• Clinical study of effect of the edema of leg by the intake of calcium alginate content food for adult woman

  澤邊 昭義; 福田 靖; 上野 昌樹  食生活研究  33-  (2)  34  -40  2013
• ワイン圧搾残渣に含まれる抗糖化作用物質の探索

  川村晴希; 竹田竜嗣; 飯田彰; 若林雄平; 濱原典正; 米虫節夫; 沢辺昭義  日本ブドウ・ワイン学会誌  23-  (2)  96  -97  2012/11
• 酵母アッセイ法を用いた植物由来環境ホルモン様活性物質の探索(2)

  沢辺昭義; 向井渉子; 笹井勝章; 澤本拓真; 中島大介; 白石不二雄; 竹田竜嗣; 飯田彰  環境化学討論会要旨集(CD-ROM)  21st-  ROMBUNNO.P-205  2012/07
• ワイン圧搾残渣に含まれる血糖調節活性物質の探索

  中谷太一; 竹田竜嗣; 飯田彰; 松浦信康; 若林雄平; 濱原典正; 米虫節夫; 沢辺昭義  日本ブドウ・ワイン学会誌  22-  (2)  98  -99  2011/11
• 酵母アッセイ法を用いた植物由来環境ホルモン様活性物質の探索

  笹井勝章; 澤本拓真; 中島大介; 白石不二雄; 飯田彰; 沢辺昭義  環境化学討論会要旨集(CD-ROM)  20th-  ROMBUNNO.2C-01  2011/07
• イタドリに含まれる抗アレルギー活性物質の探索

  川村晴希; 竹田竜嗣; 中村貴俊; 藤井善之; 井上俊夫; 飯田彰; 沢辺昭義  日本農芸化学会大会講演要旨集  2011-  227  2011/03
• 梅の機能性物質の探索

  沢辺昭義; 中谷太一; 竹田竜嗣; 飯田彰; 東海林大介; 濱田洋  日本農芸化学会大会講演要旨集  2011-  23  2011/03
• 植物芳香成分による精神的な環境ストレス緩和評価

  沢辺昭義; 戸島猛; 竹田竜嗣; 湯川千代樹; 田中清文; 飯田彰  日本農芸化学会大会講演要旨集  2011-  235  2011/03
• ワイン圧搾残渣に含まれるアテローム性動脈硬化抑制作用物質の探索

  沢辺昭義; 竹田竜嗣; 山田高也; 頓宮美樹; 川上浩平; 飯田彰; 若林雄平; 濱原典正; 米虫節夫  日本ブドウ・ワイン学会誌  21-  (2)  78  -79  2010/11
• 植物芳香成分による精神的な環境ストレス緩和評価 その2

  沢辺昭義; 竹田竜嗣; 湯川千代樹; 田中清文; 飯田彰  香料・テルペンおよび精油化学に関する討論会講演要旨集  54th-  24  -26  2010/10
• イタドリに含まれる抗アレルギー活性物質の探索

  沢辺昭義; 竹田竜嗣; 中村貴俊; 藤井善之; 井上俊夫; 豊田又文; 飯田彰  香料・テルペンおよび精油化学に関する討論会講演要旨集  54th-  118  -120  2010/10
• フェロモン様天然香料のリフレッシュ評価

  戸嶋猛; 竹田竜嗣; 高橋一弘; 山口隆司; 飯田彰; 沢辺昭義  香料・テルペンおよび精油化学に関する討論会講演要旨集  54th-  220  -222  2010/10
• Smilax glabraに含まれる化粧品有効成分の探索(2)

  久保田梨裕; 大黒真也; 飯田彰; 沢辺昭義  香料・テルペンおよび精油化学に関する討論会講演要旨集  54th-  115  -117  2010/10
• 植物に含まれる環境ホルモン様活性物質の探索

  笹井勝章; 澤本拓真; 戸嶋猛; 鄭致孝; 竹田竜嗣; 中島大介; 白石不二雄; 飯田彰; 沢辺昭義  日本農芸化学会関西支部講演会講演要旨集  466th-  35  2010/10
• Geo‐REXによるヒ素およびセレン含有土壌の迅速分析評価

  若林雄平; 仲川一彰; 竹田竜嗣; 飯田彰; 若月利之; 玉木聡史; 岩佐航一郎; 沢辺昭義  日本土壌肥料学会講演要旨集  56-  (56)  283  -283  2010/09
• 霊芝に含まれるトリテルペン類とそれらの化粧品への利用について

  久保田梨裕; 粟飯原茜; 辻本早智; 竹田竜嗣; 飯田彰; 沢辺昭義  日本きのこ学会大会講演要旨集  14th-  107  2010/09
• 植物に含まれる環境ホルモン様活性物質の探索

  笹井勝章; 戸嶋猛; TYON Tihyo; 竹田竜嗣; 中島大介; 白石不二雄; 飯田彰; 沢辺昭義  環境化学討論会講演要旨集  19th-  70  -71  2010/06
• ヨウシュヤマゴボウ毛状根を用いた環境浄化の基礎的研究 その2

  富田真人; 竹田竜嗣; 大久保智史; 山本むつみ; 渡邉泉; 飯田彰; 澤邊昭義  環境化学討論会講演要旨集  19th-  832  -833  2010/06
• Smilax glabraに含まれる美肌有効成分の探索

  久保田梨裕; 伊藤まえみ; 大黒真也; 竹田竜嗣; 飯田彰; 沢辺昭義  日本農芸化学会大会講演要旨集  2010-  140  2010/03
• ブラジル原産Tabebuia avellanedaeカルスによるがん細胞増殖抑制活性ナフトキノン類の生産

  竹中章泰; 清水勇輝; 富田真人; 竹田竜嗣; 沢辺昭義; 金子雅文; 山下光明; 徳田春邦; 飯田彰  日本薬学会年会要旨集  130th-  (2)  194  2010/03
• 大和川水系河川及び奈良市近郊溜池における環境水の遺伝毒性モニタリング

  笹井勝章; 北澤優也; 竹田竜嗣; 鎌田亮; 影山志保; 中島大介; 白石不二雄; 後藤純雄; 飯田彰; 沢辺昭義  環境化学討論会講演要旨集  19th-  2010
• ワインに含まれるアテローム性動脈硬化抑制作用物質の探索―ワイン圧搾残渣有効利用を目的とした―

  沢辺昭義; 竹田竜嗣; 飯田彰; 濱原典正; 米虫節夫  日本ブドウ・ワイン学会誌  20-  (3)  104  -105  2009/11
• Investigation of functional molecules in Noni (Morinda citnfolia) and their usefulness evaluation

  水野加奈; 中谷太一; 大迫由佳; 中村貴俊; 渡具知豊; 野池利彰; 池内正寿; 竹田竜嗣; 飯田彰; 沢辺昭義  香料・テルペンおよび精油化学に関する討論会講演要旨集  53rd-  171  -173  2009/11
• Investigation of bioactive compounds in Polygonum cuspidatum

  中村貴俊; 藤井善之; 水野加奈; 豊田又文; 笹井勝章; 竹田竜嗣; 飯田彰; 沢辺昭義  香料・テルペンおよび精油化学に関する討論会講演要旨集  53rd-  168  -170  2009/11
• Evaluation and characterization of functional molecules in Ganoderma lucidum

  粟飯原茜; 久保田梨裕; 飯田彰; 沢辺昭義  香料・テルペンおよび精油化学に関する討論会講演要旨集  53rd-  165  -167  2009/11
• Investigation of a functional ingredient in a plant perfume component and their environmental harmony evaluation

  沢辺昭義; 竹田竜嗣; 湯川千代樹; 田中清文; 飯田彰  香料・テルペンおよび精油化学に関する討論会講演要旨集  53rd-  251  -253  2009/11
• Investigation of bioactive compounds in Smilax glabra and their cosmetic usefulnes

  久保田梨裕; 伊藤まえみ; 大黒真也; 飯田彰; 沢辺昭義  香料・テルペンおよび精油化学に関する討論会講演要旨集  53rd-  344  -346  2009/11
• イタドリ(Polygonum cuspidatum)に含まれる機能性物質の探索および有用性評価について

  中村貴俊; 藤井善之; 水野加奈; 中東恵介; 笹井勝章; 竹田竜嗣; 飯田彰; 沢辺昭義  日本農芸化学会関西支部講演会講演要旨集  2009-  167  2009/10
• 霊芝に含まれる機能性物質の探索およびその有用性評価

  粟飯原茜; 久保田梨裕; 竹田竜嗣; 飯田彰; 沢辺昭義  日本農芸化学会関西支部講演会講演要旨集  2009-  168  2009/10
• ノニ(Morinda citrifolia)に含まれる機能性物質の探索および有用性評価について

  水野加奈; 中谷太一; 大迫由佳; 中村貴俊; 渡具知豊; 野池利彰; 池内正寿; 竹田竜嗣; 飯田彰; 沢辺昭義  日本農芸化学会関西支部講演会講演要旨集  2009-  168  2009/10
• 澱粉麺「マロニー」の食後血糖,血中脂質濃度の経時変化と長期摂取における腸内環境の変化

  竹田竜嗣; 川上芳緒; 河内幸枝; 飯田彰; 澤邊昭義  食品薬学シンポジウム講演要旨集  3rd-  213  -215  2009/10
• ヨウシュヤマゴボウの毛状根を用いた環境浄化

  富田真人; 竹田竜嗣; 大久保智史; 南加容; 渡邉泉; 飯田彰; 沢辺昭義  日本土壌肥料学会講演要旨集  55-  (55)  297  -297  2009/09
• 霊芝に含まれる機能性物質の探索およびその有用性評価

  粟飯原茜; 久保田梨裕; 中村貴俊; 竹田竜嗣; 飯田彰; 沢辺昭義  日本きのこ学会大会講演要旨集  13th-  81  2009/09
• 奈良県における環境水の環境分析とIn vitroバイオアッセイを用いた曝露モニタリング

  生嶋一貴; 笹井勝章; 竹田竜嗣; 緒方浩史; 鎌田亮; 影山志保; 中島大介; 白石不二雄; 飯田彰; 沢辺昭義  環境化学討論会講演要旨集  18th-  606  -607  2009/06
• GeoREXを用いた水稲およびバングラデシュ土壌の迅速分析評価

  仲川一彰; 菊池康太; 竹田竜嗣; 鈴木肖子; 玉木聡史; 岩佐航一郎; 飯田彰; 若月利之; 沢辺昭義  環境化学討論会講演要旨集  18th-  774  -775  2009/06
• ヨウシュヤマゴボウ毛状根を用いた環境浄化の基礎的研究

  富田真人; 竹田竜嗣; 大久保智史; 南加容; 渡邊泉; 飯田彰; 澤邊昭義  環境化学討論会講演要旨集  18th-  758  -759  2009/06
• 21 「Geo-REX^」による水稲及び土壌中の重金属の迅速オンサイト分析(関西支部講演会,2007年度各支部会)

  仲川 一彰; 竹田 竜嗣; 若林 雄平; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (54)  309  -309  2008/09
• クロガネモチに含まれるトリテルペン系サポニン類の化粧品有用性評価

  沢辺昭義; 阪谷圭祐; 鈴木史哉; 嶋田奈央子; 千葉友美; 米虫節夫; 飯田彰  天然有機化合物討論会講演要旨集  50th-  (50)  291  -296  2008/09
• Use development of functional materials in the leaves of Perilla frutescens (L.) Britton var. acuta Kudo (red perilla) with Japanese dietary pickled plum (Umeboshi)

  A. Sawabe; T. Satake; R. Aizawa; C. Ozeki; Y. Hamada; S. Komemushi  PLANTA MEDICA  74-  (9)  1160  -1161  2008/07
• In vitroバイオアッセイを用いる河川水の曝露モニタリングに関する基礎的研究-その1;日本の13都道府県80河川水試料の調査-

  白石不二雄; 中島大介; 鎌田亮; 影山志保; 小塩正朗; 大谷仁己; 永洞真一郎; 高橋悟; 大金仁一; 堀内孝信; 河合渉; 一二三純子; 福田武史; 原口公子; 末吉恵子; 生嶋一貴; 沢辺昭義; 門上希和夫; 後藤純雄; 滝上英孝; 鑪迫典久; 白石寛明; 鈴木規之  環境化学討論会講演要旨集  17th-  2008
• 奈良県における環境水の環境分析とin vitroバイオアッセイを用いたモニタリング

  生嶋一貴; 竹田竜嗣; 松嶋信元; 河内洋輔; 鎌田亮; 影山志保; 中島大介; 白石不二雄; 米虫節夫; 澤邊昭義  環境化学討論会講演要旨集  17th-  2008
• 14 カートリッジ型分析システム>による土壌中重金属の迅速オンサイト分析(関西支部講演会,2006年度各支部会)

  竹田 竜嗣; 仲川 一彰; 清水 大輔; 岩佐 航一郎; 玉木 聡史; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (53)  285  -285  2007/08
• 2 栽培条件がウリ科および草本植物の重金属の集積に与える影響(関西支部講演会, 2005年度各支部会講演要旨)

  佐藤 有希子; 竹田 竜嗣; 吉村 瑠美; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (52)  290  -290  2006/09
• 22-44 多環芳香族炭化水素類が植物根圏に与える影響(22.環境保全,日本土壌肥料学会 2005年度大会講演要旨集)

  中江 大輝; 竹田 竜嗣; 坂上 吉一; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (51)  180  -180  2005/09
• P22-2 マイクロバブルを用いた溜め池の浄化とバイオアッセイ(ポスター紹介,22.環境保全,日本土壌肥料学会 2005年度大会講演要旨集)

  清水 大輔; 竹田 竜嗣; 田中 克昌; 田中 義純; 田中 健二; 仲川 一彰; 横山 佳幸; 坂上 吉一; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (51)  182  -182  2005/09
• P22-9 栽培条件がウリ科および草本植物の重金属集積に与える影響(ポスター紹介,22.環境保全,日本土壌肥料学会 2005年度大会講演要旨集)

  吉村 瑠美; 佐藤 有希子; 竹田 竜嗣; 坂上 吉一; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (51)  184  -184  2005/09
• 22-43 PAHs分解菌の探索と評価(22.環境保全,日本土壌肥料学会 2005年度大会講演要旨集)

  幾馬 功昌; 竹田 竜嗣; 坂上 吉一; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (51)  179  -179  2005/09
• 9 重金属が植物細胞に与える影響(関西支部講演会,日本土壌肥料学会 支部講演会講演要旨集 2005年度)

  山田 亮; 竹田 竜嗣; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (51)  287  -287  2005/09
• ファイトレメディエーション(3)植物の重金属集積メカニズム(1)

  竹田 竜嗣; 米虫 節夫; 沢辺 昭義  環境管理技術  23-  (4)  29  -33  2005/08
• ファイトレメディエーション(2)植物の重金属集積能力

  竹田 竜嗣; 米虫 節夫; 沢辺 昭義  環境管理技術  23-  (3)  38  -42  2005/06
• ファイトレメディエーション．Ⅲ －植物の重金属集積メカニズム－

  竹田 竜嗣; 米虫 節夫; 沢辺 昭義  環境管理技術  23 (4), 29-33-  (5)  47  -51  2005
• ATPアナライザーAccuPointによる微生物・食品残渣の簡易測定法について

  News Letter “Daiichi”  6, 7-9-  2005
• ファイトレメディエーション．Ⅱ －植物の重金属集積能力－

  環境管理技術  23 (3), 38-42-  2005
• ファイトレメディエーション －環境浄化能力の高い植物を求めて－

  竹田 竜嗣; 米虫 節夫; 沢辺 昭義  環境管理技術  23 (2), 49-56-  (2)  49  -56  2005
• 奈良市周辺の閉鎖系水域における重金属の挙動とミジンコを用いたバイオアッセイ(関西支部講演会, 日本土壌肥料学会支部講演会講演要旨集2004年度)

  竹田 竜嗣; 柴田 雅之; 因幡 佳太郎; 石田 勝也; 松本 貞義; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (50)  312  -312  2004/09
• 奈良市近郊における土壌中の多環芳香族炭化水素類 (PAHs) の動態調査(関西支部講演会, 日本土壌肥料学会支部講演会講演要旨集2004年度)

  幾馬 功昌; 竹田 竜嗣; 松本 貞義; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (50)  304  -304  2004/09
• 水辺植物による重金属の集積(22. 環境保全, 2004年度大会講演要旨集)

  竹田 竜嗣; 蜂谷 健; 松本 貞義; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (50)  179  -179  2004/09
• (52) Biological Control of Powdery Mildew and Gray Mold of Tomato by Chitinolytic Phylloepiphytes (VII) : Stable Phylloplane Colonization by Entomopathogenic Bacterium Pseudomonas fluorescens KPM-018P (Abstracts Presented at the Meeting of the Kansai Division) (Abstracts of Papers Presented at the Division Meetings of the Phytopathological Society of Japan, 2003)

  Azuma N.; Matsuda Y.; Fujiwara K.; Otsu Y.; Nonomura T.; Kakutani K.; Sawabe A.; Tosa Y.; Mayama S.; Toyoda H.  Annals of the Phytopathological Society of Japan  70-  (1)  70  -70  2004/02
• カテキン茶でダイエット

  澤邊 昭義  日経ヘルス 2004.1号  88  -89  2003/12
• 17 土の黒色度とメラニン化の関係(関西支部講演会)

  竹田 竜嗣; 川村 三郎; 山根 めぐみ; 松本 貞義; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (49)  292  -292  2003/08
• 2-14 土の易分解性アミノ酸とメラニン物質の関係(2.土壌有機・無機化学)

  竹田 竜嗣; 川村 三郎; 山根 めぐみ; 松本 貞義; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (49)  18  -18  2003/08
• 22-48 草本植物による重金属の集積とファイトレメディエーションへの適用(22.環境保全)

  竹田 竜嗣; 福岡 勘介; 森田 真弘; 蜂谷 健; 川村 三郎; 松本 貞義; 米虫 節夫; 沢辺 昭義  日本土壌肥料学会講演要旨集  (49)  178  -178  2003/08
• 37 土壌砂の細粒化の実態予測について(関西支部講演会)

  川村 三郎; 竹田 竜嗣; 坂下 卓; 沢辺 昭義  日本土壌肥料学会講演要旨集  (48)  241  -241  2002/03
• 微生物遺伝子の利用による香気成分生産とその利用開発

  沢辺 昭義; 松田 克礼; 豊田 秀吉  Foods Food Ingredients J. Jpn  207, 23-30-  (207)  23  -30  2002
• 植物由来のクロロゲン酸代謝産物を用いた化粧品素材としての配糖体の合成とその美白効果に関する研究

  野村 正人; 澤辺 昭義; 藤原 義人  Cosmetology  10, 2-7-  2  -7  2002
• アフリカ産食用葉、ノゲイトウに含まれる美白物質

  野村 正人; 沢辺 昭義  近畿大学工業技術研究所研究報告書  1-  9  -13  2001
• Cosmetic Substances for Skin Depigmentation from African Dietary Leaves, Celosia argentea L.

  沢辺 昭義; 野村 正人; 藤原 義人; 多田 貴広; 服部 文弘; 塩原 智子; 下村 健次; 松原 義治; 米虫 節夫; 岡本 忠; 川村 三郎  Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University  (9)  141  -146  2001
• アフリカ産食用葉,ノゲイトウに含まれる美白物質

  沢辺 昭義; 野村 正人  Fragrance Journal  28-  (9)  54  -58  2000
• Structural characterization of glycolipids in edible mushroom by FAB/MS

  Sawabe Akiyoshi; Morita Masanori; Ouchi Seiji; Okamoto Tadashi  Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University  (7)  37  -46  1999/03
• 植物の香りとその化学構造

  近藤大学農学総合研究所報告  (6)  115  1998
• Characterization of Functional Molecules Isolated from Mushrooms by Mass Spectrometry

  沢辺 昭義; 岡本 忠  Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University  (5)  105  -119  1997
• 甘夏柑およびスダチ果皮中のテルペノイド配糖体 : 有機化学・天然物化学

  沢辺 昭義; 小畑 貴央; 森田 全律; 峯松 敏江; 山下 那都樹; 松原 義治  日本農藝化學會誌  70-  230  -230  1996/03
• 機能性天然物分子の探索(2) : 食用キノコに含まれる新しいタイプのスフィンゴ燐糖脂質 : 有機化学・天然物化学

  沢辺 昭義; 森田 全律; 稲葉 和功; 大内 成志; 岡本 忠  日本農藝化學會誌  70-  230  -230  1996/03
• MSによりキノコ類の機能性分子の構造を探る

  澤邊 昭義; 岡本 忠  ニューフードインダストリー  38-  (11)  45  -56  1996  [Invited]
  
• 天然機能性フェノール.III.-タンニン-

  近畿大学農学総合研究所報告  (4)  1  1996
• 柑橘類果皮中の生物活性物質

  沢辺 昭義; 松原 義治  FFI ジャーナル  169-  (169)  37  -44  1996
• Search for Structures of Functional Molecules from Mushrooms by Mass Spectrometry

  SAWABE Akiyoshi  New Food Industry  38-  (11)  45  1996
• Natural Functional Phenols.III. Tannins

  SAWABE Akiyoshi  Bull.Inst.Compr.Agr.Sci.Kinki Univ.  (4)  1  1996
• Bioactive Compounds in Citrus Fruit Peels

  SAWABE Akiyoshi  Foods Food Ingredients J.Jpn.  169-  37  1996
• 機能性天然物分子の探索(1) : 食用キノコ類に含まれる脂質のFAB/MSによる構造解析 : 有機化学・天然物化学

  沢辺 昭義; 森田 全律; 稲葉 和功; 大内 成志; 岡本 忠  日本農藝化學會誌  69-  231  -231  1995/07
• 天然能性フェノール.II. -抗真菌活性をもつフェノール性抗生物質-

  近畿大学農学総合研究報告  (3)  9  1995
• 有機合成におけるリン酸基の保護

  澤邊 昭義; 岡本 忠  近畿大学農学総合研究所報告  (3)  17  1995
• Natural Functional Phenols. II. Phenolics as Antifungal Antibiotics.

  SAWABE Akiyoshi  Bulletin of The Institute for Comprehensive Agricultural Sciences, Kinki University  (3)  9  1995
• Protection of Phosphoryl Group in Organic Synthesis

  SAWABE Akiyoshi  Bulletin of The Institute for Comprehensive Agricultural Sciences, Kinki University  (3)  17  1995
• BIOLOGICALLY-ACTIVE COMPOUNDS IN CITRUS-FRUIT PEELS

  Y MATSUBARA; A SAWABE  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN  52-  (4)  318  -327  1994/04
• 天然機能性フェノール.I. -抗酸化剤および血圧降下作用を持つ植物性フェノール誘導体-

  近畿大学農学総合研究所報告  (2)  1  1994
• Natural Functional Phenols. I. Plant Phenolics as Antioxidants and Hypotensive Materials.

  SAWABE Akiyoshi  Bulletin of The Institute for Comprehensive Agricultural Sciences, Kinki University  (2)  1  1994
• Constituents of Essential Oil in the Leaf and Flower of Getto (┣DBAlpina speciosa(/)-┫DB K. Schem. )

  MATSUBARA Yoshiharu; MORITA Masanori; KATSUI Akira; SAWABE Akiyoshi  J. Jpn. Oil Chem. Soc. (YUKAGAKU)  43-  (5)  424  -427  1994
• STRUCTURE OF STEROIDS IN LEMON (CITRUS-LIMON BURM F) PEELINGS

  Y MATSUBARA; A SAWABE; Y IIZUKA  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY  63-  (6)  1115  -1117  1989/06  [Refereed]
  
• Structures and Physiological Activity of Nitrogenous Compounds and Aokyl Glycosides in Lemon (┣DBCitus limon(/)-┫DB BURM. ┣DBf(/)-┫DB. ), Unshiu (┣DBCitrus unshiu(/)-┫DB MARCOV. ), Hassaku(┣DBCitrus hassaku(/)-┫DB HORT. ), Yuzu (┣DBCitrus junos(/)-┫DB ・・・

  SAWABE Akiyoshi  Nippon Nogeikagaku Kaishi  63-  (8)  1373  1989  [Refereed]
  
• STRUCTURE OF TERPENOIDS AND TERPENOID GLYCOSIDES IN UNSHIU (CITRUS-UNSHIU MARCOV) AND YOUNG UNSHIU (YOUNG CITRUS-UNSHIU MARCOV) PEELINGS

  A SAWABE; Y MATSUBARA; Y IIZUKA  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY  62-  (10)  1475  -1477  1988/10  [Refereed]
  
• Structure and physiological activity of nitrogenoused compound and alkyl glycosides in unshiu (Citrus unshiu), hassaku (Citrus hassaku HORT.), yuzu (Citrus junos SIEB.) and iyokan (Citrus iyo) peelings

  MATSUBARA Yoshiharu; MIZUNO Takahiko; SAWABE Akiyoshi; IIZUKA Yoshitomi; OKAMOTO Kozo  Medical journal of Kinki University  13-  (4)  61  -69  1988
• Structures and Physiological Activity of Nitrogenous Compounds and Alkyl Glycosides in Unshiu (┣DBCitrus unshiu(/)-┫DB MARCOV. ), Hassaku (┣DBCitrus hassaku(/)-┫DB HORT. ), Yuzu (┣DBCitrus junos(/)-┫DB SIEB. ), and Iyokan (┣DBCitrus iyo(/)-┫DB)peelings

  SAWABE Akiyoshi  Medical Journal of Kinki University  13-  (4)  61  -69  1988
• Structures of flavonoid glycosides and adenosine and their hypotensive effects in iyokan (Citrus iyo), young unshiu (young Citrus unshiu) and kinkan (Fortunella japonica) peelings

  MATSUBARA Yoshiharu; SAWABE Akiyoshi; MIZUNO Takahiko; IIZUKA Yoshitomi; OKAMOTO Kozo  Medical journal of Kinki University  12-  (4)  89  -101  1987
• Structures of Flavonoid Glycosides and Adenosine and their hypotensive effects in Iyokan (┣DBCitrus iyo(/)-┫DB), Young Unshiu (young ┣DBCitrus unshiu(/)-┫DB) and Kinkan (┣DBFortunella japoneca(/)-┫DB)Peelings

  SAWABE Akiyoshi  Medical Journal of Kinki University  12-  (4)  89  -101  1987
• Structure and physiological activity of phenyl propanoid glycosides on kinkan (Fortunella japonica), sudachi (Citrus sudachi), yuzu (Citrus junos SIEB.), zabon (Citrus gradis OSBECK.) and unshiu (Citrus unshiu) peelings

  MATSUBARA Yoshiharu; SAWABE Akiyoshi; UENO Koichi; IIZUKA Yoshitomi; OKAMOTO Kozo  Medical journal of Kinki University  11-  (4)  65  -72  1986
• Structures and Physiological Activity of Phenyl Propanoid Gkycosides in Kinkan (┣DBFortunella japonica(/)-┫DB), SUDACHI(┣DBCitrus sudachi(/)-┫DB), Yuzu (┣DBCitrus junos(/)-┫DB SIEB. ), Zabon (┣DBCitrus gradis(/)-┫DB OSBECK. ), and Unshiu (┣DBCitrus uns・・・

  SAWABE Akiyoshi  Medical Journal of Kinki University  11-  (4)  65  -72  1986
• レモン,温州みかん オレンジ果皮中のフェニルプロパノイド配糖体の構造と生理活性

  近畿大学医学雑誌  10-  (4)  51  1985
• レモンおよび温州みかん果皮中のリモノイド配糖体の構造

  近畿大学医学雑誌  10-  (4)  59  1985

Industrial Property Rights

• 特願2006-216081(P2006-216081):紅花のエストロゲン様作用を有する抽出物を配合してなる化粧料  2006年/08/08

  澤邊昭義, 米虫節夫, 山口隆司, 高橋一弘
• アテローム性動脈硬化抑制剤ならびにこれを含む食品および医薬

  特願2004-014836
• 毛状根を用いたメロン香気成分，その製造法および用途

  特開2000-297291
• シトラシンＣを配合した化粧料，医薬外品，医薬品および食品

  特開2000-169358
• Isolation of physiologically active cyclic peptides from citrus fruits and rinds

  JP 04 46,195 [92 46,195]

Awards & Honors

• 2014/03 優秀論文賞
   成人男性を対象とした、アルギン酸カルシウム含有食品の単回摂取による食後の血中中性脂肪値および血糖値におよぼす影響 

  受賞者: 澤邊 昭義

Research Grants & Projects

• Action-training-research aiming at the development of healthy longevity and the new functional foods which non-illness effect could expect

  Kindai University：21st Century Joint Research Enhancement Grant from Kindai University

  Date (from‐to) : 2020/04 -2023/03
• 高付加価値化をめざした食用資源の健康長寿・未病効果の科学的評価

  Kindai University：21st Century Joint Research Enhancement Grant from Kindai University

  Date (from‐to) : 2017/04 -2020/03
• A source of pollution investigation of the contaminated soil and examination to environmental harmony

  Kindai University：21st Century Joint Research Enhancement Grant from Kindai University

  Date (from‐to) : 2014/04 -2015/03 

  Author : Akiyoshi Sawabe
• Study on refreshment and relaxation effect of the life space perfume component

  日本食品化学研究振興財団：日本食品化学研究振興財団 研究助成

  Date (from‐to) : 2009/04 -2011/03 

  Author : Akiyoshi Sawabe
• Search of the metaloam on heavy metal detoxication mechanism and environmental stresses.

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2009 -2011 

  Author : SAWABE Akiyoshi; TAKEDA Ryuji

   

  We compared the official method using AAS or with our new quick heavy metal measuring system based on voltammetry method. Then we considered whether analysis of cadmium on paddy-rice investigation was possible. As for the measurement of heavy metals by microcartridge type electrochemistry analysis machine, measurement was possible in lower than 10 ppb which was Japanese reference value easily, and manipulation was simple and easy. Also we examined the influence that we used a pumpkin as a clue of a heavy metal detoxication mechanism by this study, and Mn presence gave glutathione dosage in one of the defence materials in Pb accumulation dosage in Pb exposition and microelement and organism. As a result, Mn presence affected rhizoma interlobar Ca distribution. In addition, Mn free experiment area showed a rise of GSH/GSSG rate in leaf region conspicuously. In Pb concentration(400 ppm), it compared it with Mn presence experiment area in Mn free experiment area and decreased conspicuously. From these results, it was suggested that Mn functions for an action of a glutathione-related enzymatic group.
• Search of atherosclerosis inhibitor

  Kinki University：Research Enhancement Grant from Kinki University

  Date (from‐to) : 2003/04 -2004/03 

  Author : Akiyoshi Sawabe
• Elucidation of mechanism of production of the bitter principles involved in Hypsizigus marmoreus generation process

  ホクト生物科学振興財団：ホクト生物科学振興財団 研究助成

  Date (from‐to) : 2002 

  Author : Akiyoshi Sawabe
• Isolation and synthesis of the whitening active substance in Hibiscus sabdariffa from Africa

  Kinki University：Research Enhancement Grant from Kinki University

  Date (from‐to) : 2000/04 -2001/03 

  Author : Akiyoshi Sawabe
• Search of the new food additive in African plants, and their utilization as cosmetics

  三栄源食品化学研究振興財団：三栄源食品化学研究振興財団 研究助成

  Date (from‐to) : 1999/04 -2001/03 

  Author : Akiyoshi Sawabe
• Utilization and biosynthesis of the melon fruit aroma components in the melon hairy root

  Kinki University：Research Enhancement Grant from Kinki University

  Date (from‐to) : 1996/04 -1999/03 

  Author : Seiji Ouchi; Hideyoshi Toyoda; Akiyoshi Sawabe; Yoshinori Matsuda; Kazuhiko Maeda
• Isolation and the characterization of new functional lipids

  Kinki University：Research Enhancement Grant from Kinki University

  Date (from‐to) : 1995/04 -1996/03 

  Author : 澤邊昭義
• Search for functional molecules in nature

  Kinki University：Research Enhancement Grant from Kinki University

  Date (from‐to) : 1994/04 -1995/03 

  Author : Akiyoshi Sawabe
• 柑橘類果皮中の生物活性物質
• Biologically active compounds in Citrus fruit peels

Media Coverage

• 摘果柿を有効利用 食品の風味劣化を抑えて動脈硬化の予防もできる機能性素材の開発へ

  Date : 2020/11

  Writer: Other than myself

  Publisher, broadcasting station: 日本の身土不二

  Internet
• コリアンダーシードの抗糖化作用を確認 老化の原因物質 "AGE" の蓄積を抑制する食品の開発を目指す

  Date : 2020/10

  Writer: Other than myself

  Publisher, broadcasting station: 日本の身土不二

  Internet
• 注目浴びる 「アルギン酸」とは？

  Date : 2013/03

  Writer: Other than myself

  Program, newspaper magazine: 日経流通新聞（日経MJ）

  Paper
• カテキン茶でダイエット

  Date : 2004/01

  Writer: Other than myself

  Program, newspaper magazine: 日経ヘルス

  Paper

Others

• 2013/10 -2013/10  Receiving a prize of the graduate student 

  Hiromi Kawabata Best Poster Award 4th International Conference and Exhibition on Analytical & Bioanalytical Techniques held on October 15-17, 2013 in Hampton Inn Tropicana, Las Vegas, USA.

Other link

researchmap

https://researchmap.jp/read0185893