KUSAKA Shunji

Department of MedicineProfessor/Senior Staff

Last Updated :2024/09/21

■Researcher comments

List of press-related appearances

1

■Researcher basic information

Degree

  • (BLANK)(Osaka University)

Research Keyword

  • 眼科学   ophthalmology   

Research Field

  • Life sciences / Ophthalmology

■Career

Career

  • 2018  近畿大学医学部眼科学教室主任教授
  • 2010  近畿大学医学部堺病院眼科教授
  • 2004  大阪大学大学院医学系研究科眼科准教授・病院教授
  • 2002  大阪府立急性期・総合医療センター眼科部長
  • 1997  Osaka University眼科助手・講師
  • 1994  ミシガン大学眼科研究員
  • 1992  Ehime University眼科助手

Educational Background

  •        - 1986  Osaka University  Faculty of Medicine  Medical School

■Research activity information

Paper

  • Kondo H; Tsukahara-Kawamura T; Matsushita I; Nagata T; Hayashi T; Nishina S; Higasa K; Uchio E; Kondo M; Sakamoto T; Kusaka S
    Ophthalmol Sci . Elsevier BV 4 (5) 100514 - 100514 2666-9145 2024/09
  • Sivalingam MD, Wakabayashi T, Kusaka S, Yonekawa Y.
    Ophthalmic Surg Lasers Imaging Retina SLACK, Inc. 55 (8) 430 - 432 2325-8160 2024/08
  • Mizobuchi K, Hayashi T, Tanaka K, Kuniyoshi K, Murakami Y, Nakamura N, Torii K, Mizota A, Sakai D, Maeda A, Kominami T, Ueno S, Kusaka S, Nishiguchi M K, Ikeda Y, Kondo M, Tsunoda K, Hotta Y, Nakano T.
    Am J Ophthalmol . Elsevier BV 264 36 - 43 0002-9394 2024/08
  • Wakayama A, Matsumoto C, Utamura K, Narita R, Kusaka S.
    Jpn J Ophthalmol . Springer Science and Business Media LLC 0021-5155 2024/05
  • Binenbaum G, Stahl A, Coyner AS, He J, Ying GS, Ostmo S, Chan RVP, Toth C, Vinekar A, Campbell JP; International Classification of Retinopathy of Prematurity Committee.
    Ophthalmology Elsevier BV online (online) 0161-6420 2024/05
  • Sugioka K; Nishida T; Murakami J; Itahashi M; Yunoki M; Kusaka S.
    Am J Physiol Cell Physiol. AM. PHYSIOLOGICAL SOCIETY 326 (5) C1482 - C1493 2024/05 
    Corneal fibroblasts maintain homeostasis of the corneal stroma by mediating the synthesis and degradation of extracellular collagen, and these actions are promoted by transforming growth factor-β (TGF-β) and interleukin-1β (IL-1β), respectively. The cornea is densely innervated with sensory nerve fibers that are not only responsible for sensation but also required for physiological processes such as tear secretion and wound healing. Loss or dysfunction of corneal nerves thus impairs corneal epithelial wound healing and can lead to neurotrophic keratopathy. The sensory neurotransmitter substance P (SP) promotes corneal epithelial wound healing by enhancing the stimulatory effects of growth factors and fibronectin. We have now investigated the role of SP in collagen metabolism mediated by human corneal fibroblasts in culture. Although SP alone had no effect on collagen synthesis or degradation by these cells, it promoted the stimulatory effect of TGF-β on collagen type I synthesis without affecting that of IL-1β on the expression of matrix metalloproteinase-1. This effect of SP on TGF-β-induced collagen synthesis was accompanied by activation of p38 mitogen-activated protein kinase (MAPK) signaling and was attenuated by pharmacological inhibition of p38 or of the neurokinin-1 receptor. Our results thus implicate SP as a modulator of TGF-β-induced collagen type I synthesis by human corneal fibroblasts, and they suggest that loss of this function may contribute to the development of neurotrophic keratopathy.NEW & NOTEWORTHY This study investigates the role of substance P (SP) in collagen metabolism mediated by human corneal fibroblasts in culture. We found that, although SP alone had no effect on collagen synthesis or degradation by corneal fibroblasts, it promoted the stimulatory effect of transforming growth factor-β on collagen type I synthesis without affecting that of interleukin-1β on the expression of matrix metalloproteinase-1.
  • 小児眼内注入留置物質
    福島 正樹, 日下 俊次
    眼科手術 37 (2) 141 - 146 2024/04
  • Clinical course of two siblings with potassium voltage-gated channel modifier subfamily V member 2 (KCNV2)-associated retinopathy
    Sato T, Kuniyoshi K, Hayashi T, Nishiwaki H, Mizobuchi K, Kusaka S.
    Doc Ophthalmol. springer 2024/04
  • Okubo M; Mano F; Hashimoto R; Maeno T; Kuniyoshi K; Kusaka S
    Retina Ovid Technologies (Wolters Kluwer Health) 44 (8) 1463 - 1469 0275-004X 2024/04 
    Purpose: This study aimed to determine the incidence of the Amalric triangular sign (ATS) in patients with central retinal artery occlusion (CRAO) and investigate its association with visual function and carotid Doppler ultrasonography findings. Methods: A retrospective chart review was conducted on 21 eyes from 21 cases with complete CRAO. Best-corrected visual acuity (BCVA) and carotid Doppler ultrasonography findings [peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index (RI) = (PSV-EDV)/PSV] were investigated. Results: Three patients (14%) exhibited the ATS. BCVA at first visit was significantly worse in ATS-positive than in ATS-negative (P = 0.024). Doppler waveform analysis of the common carotid artery (CCA) showed that ATS-positive patients had a significantly lower EDV [P = 0.009, median 10 (range 9–10) vs. 17 (13–24) m/s] and significantly higher RI [P = 0.021, median 0.80 (range 0.79–0.83) vs. 0.72 (0.66–0.82)] than did ATS-negative. Conclusions: The ATS was observed in three patients with CRAO, who showed worse BCVA at the first visit than did those without the ATS. Carotid Doppler ultrasonography revealed that ATS-positive patients had a significantly higher RI and lower EDV at the CCA than did ATS-negative, indicating steno-occlusive changes in the internal carotid artery.
  • Goto K; Koyanagi Y; Akiyama M; Murakami Y; Fukushima M; Fujiwara K; Iijima H; Yamaguchi M; Endo M; Hashimoto K; Ishizu M; Hirakata T; Mizobuchi K; Takayama M; Ota J; Sajiki AF; Kominami T; Ushida H; Fujita K; Kaneko H; Ueno S; Hayashi T; Terao C; Hotta Y; Murakami A; Kuniyoshi K; Kusaka S; Wada Y; Abe T; Nakazawa T; Ikeda Y; Momozawa Y; Sonoda KH; Nishiguchi KM
    Journal of Medical Genetics BMJ 61 (7) 613 - 620 0022-2593 2024/03 
    Background As gene-specific therapy for inherited retinal dystrophy (IRD) advances, unified variant interpretation across institutes is becoming increasingly important. This study aims to update the genetic findings of 86 retinitis pigmentosa (RP)-related genes in a large number of Japanese patients with RP by applying the standardised variant interpretation guidelines for Japanese patients with IRD (J-IRD-VI guidelines) built upon the American College of Medical Genetics and Genomics and the Association for Molecular Pathology rules, and assess the contribution of these genes in RP–allied diseases. Methods We assessed 2325 probands with RP (n=2155, including n=1204 sequenced previously with the same sequencing panel) and allied diseases (n=170, newly analysed), including Usher syndrome, Leber congenital amaurosis and cone-rod dystrophy (CRD). Target sequencing using a panel of 86 genes was performed. The variants were interpreted according to the J-IRD-VI guidelines. Results A total of 3564 variants were detected, of which 524 variants were interpreted as pathogenic or likely pathogenic. Among these 524 variants, 280 (53.4%) had been either undetected or interpreted as variants of unknown significance or benign variants in our earlier study of 1204 patients with RP. This led to a genetic diagnostic rate in 38.6% of patients with RP, withEYSaccounting for 46.7% of the genetically solved patients, showing a 9% increase in diagnostic rate from our earlier study. The genetic diagnostic rate for patients with CRD was 28.2%, with RP-related genes significantly contributing over other allied diseases. Conclusion A large-scale genetic analysis using the J-IRD-VI guidelines highlighted the population-specific genetic findings for Japanese patients with IRD; these findings serve as a foundation for the clinical application of gene-specific therapies.
  • A Severe Case of Infectious Necrotizing Anterior Scleritis Caused by Pseudomonas aeruginosa After Vitreoretinal Surgery
    Kayazawa M; Kodama-Takahashi A; Sugioka K; Yunoki M; Kusaka S
    Case Reports in Ophthalmology 2024
  • Utamura K, Wakayama A, Matsumoto F, Shiraishi Y, Narita I, Tanabe F, Kusaka S.
    BMC Ophthalmol. 23 (1) 469 - 469 2023/11 
    BACKGROUND: Amblyopia treatment by occluding the healthy eye is known to be effective during a sensitive critical period. This study aims to clarify the factors for the total occlusion time (TOT) required for the amblyopic eye to achieve a normal visual acuity (VA) level of 1.0 (0.0 logMAR equivalent). This could contribute to an efficient treatment plan for eyes with hyperopic anisometropic amblyopia. METHODS: Subjects were 58 patients (26 boys and 32 girls; age range, 3.6-9.2, average, 5.8 ± 1.3 years) with hyperopic anisometropic amblyopia. All the subjects had initially visited and completed occlusion therapy with improved VA of 1.0 or better in the amblyopic eye at Kindai University Hospital between January 2007 and March 2017. Using the subjects' medical records, we retrospectively investigated five factors for the TOT: the age at treatment, the initial VA of the amblyopic eye, refraction of the amblyopic eye, anisometropic disparity, and the presence of microstrabismus. Patient's VA improvement at one month after treatment was also evaluated to confirm the effect of the occlusion therapy. RESULTS: The initial VA of the amblyopic eye ranged from 0.1 to 0.9 (median, 0.4). The TOT ranged from 140 to 1795 (median, 598) hours with an average daily occlusion time of 7 hours. The initial VA of the amblyopic eye and presence of microstrabismus were the significant factors for the TOT (p < 0.01). To achieve VA of 1.0 or better, patients with an initial VA of ≤ 0.3 in the amblyopic eye required a longer TOT. Moreover, patients with concomitant microstrabismus required a 1.7-fold longer TOT compared to those without microstrabismus. CONCLUSION: Longer daily occlusion hours and early start of the treatment will be necessary for patients with poor initial VA or microstrabismus to complete occlusion therapy within the sensitive critical period.
  • Optical coherence tomography findings of the peripheral retina in patients with congenital X-linked retinoschisis
    Nakajima A, Kuniyoshi K, Iwahashi C, Mano F, Hayashi T, Kondo H, Mizobuchi K, Matushita I, Suga A, Yoshitake K, Nakano T, Iwata T, Matsumoto C, Kusaka S.
    Front Med. FrontiersMedia 10 2023/11
  • Sweeping technique for the removal of emulsified silicone oil droplets from the anterior surface of the iris using an ophthalmic absorption sponge
    Kurihara T, Iwashashi C, Mano F, Kusaka S.
    Retin Cases Brief Rep LIPPINCOTT WILLIAMS & WILKINS 2023/11
  • Iwahashi C, Sakamoto M, Ohguro N, Kusaka S.
    JAMA Ophthalmol . American Medical Association (AMA) 141 (11) 1085 - 1088 2168-6165 2023/10 
    This case report describes the use of tirabrutinib to treat 2 individuals with vitreoretinal lymphoma.
  • Catt C, Pfeil JM, Barthelmes D, Gole GA, Krohne TU, Wu WC, Kusaka S, Zhao P, Dai S, Elder J, Heckmann M, Stack J, Khonyongwa-Fernandez G, Stahl A.
    Br J Ophthalmol . BMJ 0007-1161 2023/09 
    Background/Aims The incidence of retinopathy of prematurity (ROP) is increasing and treatment options are expanding, often without accompanying safety data. We aimed to define a minimal, patient-centred data set that is feasible to collect in clinical practice and can be used collaboratively to track and compare outcomes of ROP treatment with a view to improving patient outcomes. Methods A multinational group of clinicians and a patient representative with expertise in ROP and registry development collaborated to develop a data set that focused on real-world parameters and outcomes that were patient centred, minimal and feasible to collect in routine clinical practice. Results For babies receiving ROP treatment, we recommend patient demographics, systemic comorbidities, ROP status, treatment details, ophthalmic and systemic complications of treatment, ophthalmic and neurodevelopmental outcomes at initial treatment, any episodes of retreatment and follow-up examinations in the short and long-term to be collected for use in ROP studies, registries and routine clinical practice. Conclusions We recommend these parameters to be used in registries and future studies of ROP treatment, to reduce the variation seen in previous reports and allow meaningful assessments and comparisons. They form the basis of the EU-ROP and the Fight Childhood Blindness! ROP Registries.
  • Nomoto H, Matsumoto C, Okuyama S, Kimura S, Inoue S, Yamanaka K, Kusaka S.
    Sci Rep. Nature Research 13 (1) Article number: 14945  2023/09 
    Abstract Visual field (VF) test is one of the most vital tests in the diagnosis of glaucoma and to monitor the disease worsening. In the past couple of decades, the standard automated perimetry (SAP) test takes a major role in VF test for glaucoma patients. The SAP has been demanded to finish a test in short time without sacrificing accuracy. In this study, we developed and evaluated the performance of a new perimetric algorithm (ambient interactive zippy estimation by sequential testing (ZEST): AIZE) by computer simulation. AIZE is a modification of the ZEST procedure that utilizes the spatial information (weighted likelihood: WL) of neighboring test locations, which varies from the distance to the tested location, to estimate a visual threshold. Ten glaucomatous and 10 normal empirical visual field (VF) test results were simulated with five error conditions [ (3% false positives (FP), 3% false negatives (FN)), (9% FP, 9% FN), (15% FP, 15% FN), (3% FP, 15% FN), (15% FP, 3% FN)]. The total number of test presentations and the root mean square error (RMSE) of the estimated visual sensitivities were compared among AIZE, the non-weighted test (WL = 0) and the fixed-weighted test (WL = 0.33). In both glaucomatous (G) and normal (N) VFs, the fixed-weighted test had the lowest number of test presentations (median G 256, N 139), followed by the AIZE (G 285, N 174) and the non-weighted test (G 303, N 195). The RMSE of the fixed-weighted test was lower (median 1.7 dB) than that of the AIZE (1.9 dB) and the non-weighted test (1.9 dB) for normal VFs, whereas the AIZE had a lower RMSE (3.2 dB) than the fixed-weighted test (4.5 dB) and the non-weighted test (4.0 dB) for glaucomatous VFs. Simulation results showed that AIZE had fewer test presentations than the non-weighted test strategy without affecting the accuracy for glaucomatous VFs. The AIZE is a useful time saving test algorithm in clinical settings.
  • Sugioka K, Nishida T, Kodama-Takahashi A, Murakami J, Fukuda M, Matsuo O, Kusaka S.
    Exp Eye Res . 233 109559 - 109559 2023/08 
    Urokinase-type plasminogen activator (uPA) is a serine protease that plays a central role in the pericellular fibrinolytic system, mediates the degradation of extracellular matrix proteins and activation of growth factors, and contributes to the regulation of various cellular processes including cell migration and adhesion, chemotaxis, and angiogenesis. The corneal epithelium responds rapidly to injury by initiating a wound healing process that involves cell migration, cell proliferation, and tissue remodeling. It is innervated by sensory nerve endings that play an important role in the maintenance of corneal epithelial homeostasis and in the wound healing response. We here investigated the role of uPA in corneal nerve regeneration and epithelial resurfacing after corneal injury with the use of uPA-deficient mice. Both the structure of the corneal epithelium and the pattern of corneal innervation in uPA-/- mice appeared indistinguishable from those in uPA+/+ mice. Whereas the cornea was completely resurfaced by 36-48 h after epithelial scraping in uPA+/+ mice, however, such resurfacing required at least 72 h in uPA-/- mice. Restoration of epithelial stratification was also impaired in the mutant mice. Fibrin zymography revealed that the expression of uPA increased after corneal epithelial scraping and returned to basal levels in association with completion of re-epithelialization in wild-type animals. Staining of corneal whole-mount preparations for βIII-tubulin also revealed that the regeneration of corneal nerves after injury was markedly delayed in uPA-/- mice compared with uPA+/+ mice. Our results thus demonstrate an important role for uPA in both corneal nerve regeneration and epithelial migration after epithelial debridement, and they may provide a basis for the development of new treatments for neurotrophic keratopathy.
  • Fukushima M, Hayashi A, Kusaka S, Kamei M, Tsuboi K.
    Retina Ovid Technologies (Wolters Kluwer Health) 43 (12) 2204 - 2207 0275-004X 2023/07 [Refereed]
     
    Abstract Purpose: For the treatment of lamellar macular hole (LMH), the recent development of a lamellar hole-associated epiretinal proliferation (LHEP) embedding technique is likely to improve functional and anatomical results. However, the peeling of LHEP is often technically challenging. We have developed a new technique using a backflush needle with a silicone tip cannula that seems safer and more effective for use in LHEP embedding. Methods: A 25-gauge vitrectomy system with an enhancing visual acuity (EVA) system (D.O.R.C., Zuidland, Netherlands) was used in all cases. After core vitrectomy, triamcinolone acetonide (Wakamoto Pharmaceutical Co., Ltd., Tokyo, Japan) was used to visualize the membrane. A 25-gauge backflush needle with a silicone tip cannula was used to remove the thin preretinal membrane centripetally, leaving an LHEP on the edge of the hole. Brilliant blue G (ILM Blue®; D.O.R.C.) was then used to stain the ILM. Results: This technique was used in 6 eyes with LMH. In all cases, peeling and embedding of the LHEP was effectively performed without damaging the ILM or causing retinal hemorrhage. No other intra- or postoperative complications were experienced. Conclusion: Using a silicone-tipped backflush needle with passive aspiration was a simple and effective technique for peeling and embedding of LHEPs in this small series.
  • Nagae Y, Kuniyoshi K, Ishibashi M, Tanabe F, Matsumoto C, Kusaka S.
    Doc Ophthalmol . Springer Science and Business Media LLC 147 (2) 131 - 137 0012-4486 2023/07
  • Shiraishi Y, Wakayama A, Matsumoto F, Tanabe F, Kusaka S.
    Clin Ophthalmol. Informa UK Limited Volume 17 1545 - 1553 2023/06
  • Hotta F, Eguchi H, Nakayama-Imaohji H, Shimomura Y, Kusaka S.
    Front Cell Infect Microbiol. Frontiers Media SA 13 2023/04 
    We aimed to elucidate the effects of antimicrobial eye drops used in the perioperative period of ophthalmic surgery on the ocular surface microbiome by metagenomic analysis. Twenty-eight eyes from 15 patients (mean age 74.1 years) with no history of eye drop use within 3 months before cataract surgery were included in this study. Gatifloxacin eye drops were used in all patients in the perioperative period. The antimicrobial eye drops were started 3 days before surgery. They were discontinued after conjunctival sac specimen collection for 2 weeks after the surgery. Conjunctival sac specimens were collected to investigate the alterations in the ocular surface microbiome by meta-16S analysis targeting the V3-V4 region of the bacterial 16S rRNA gene. Principal coordinate analysis showed that the bacterial composition tended to be different before and 2 and 4 weeks after surgery. Individual observations on six eyes showed that the bacterial composition at 12 weeks after surgery was closer to that before surgery than to that at 4 weeks after surgery in two eyes, while the bacterial composition in the remaining four eyes was different at various time points. Before surgery, Firmicutes, Proteobacteria, and Bacteroidetes were predominant; however, 2 weeks after surgery, the proportion of Proteobacteria increased and that of Firmicutes decreased. A similar trend was noticed 4 weeks after surgery, although antibacterial eye drops had been discontinued 2 weeks after surgery. The Shannon–Weaver coefficient showed a decreasing trend at 2-, 4-, and 12-weeks post operation compared to that before operation. The diversity of the microbiome decreased significantly at 2- and 4-weeks after surgery when compared to that before surgery (p &lt; 0.05). The ocular surface microbiome is easily disrupted by antimicrobial eye drops, and it needs recovery time. In such cases, the ocular surface microbiome is presumed to contain many antimicrobial-resistant bacteria. In some cases, it may not recover, and a new microbiome is formed.
  • Iwahashi C, Matsushita I, Kuniyoshi K, Kondo H, Kusaka S.
    Retina Ovid Technologies (Wolters Kluwer Health) 43 (1) 64 - 71 0275-004X 2023/04 [Refereed]
     
    PURPOSE: To present the clinical characteristics, surgical outcomes, and surgical complications of patients with congenital X-linked retinoschisis who underwent vitrectomy for bullous schisis cavity hanging over or threatening the macula. METHODS: Nine patients with congenital X-linked retinoschisis (12 eyes) who underwent vitrectomy at three tertiary hospitals and completed ≥3 years of postoperative follow-up were retrospectively investigated. Data were collected from patients' charts, including age at vitrectomy, surgical procedures, and postoperative complications. RESULTS: The age at vitrectomy ranged 4 months to 103 months (median: 14 months). Inner wall retinectomy was performed during the initial vitrectomy in eight eyes. Among the eight eyes that initially underwent inner wall retinectomy, one (12.5%) required subsequent retinal surgery for postoperative complication. Furthermore, four eyes did not undergo initial inner wall retinectomy but required subsequent retinal surgeries for postoperative complications. Three of five eyes (60.0%) treated with silicone oil tamponade and two of seven eyes (28.6%) that were not treated with silicone oil tamponade during the initial vitrectomy required subsequent retinal surgeries for postoperative complications. All eyes maintained a clear central visual axis at the last examination. CONCLUSION: Inner wall retinectomy seems beneficial in achieving a clear visual axis in eyes with bullous schisis cavity hanging over or threatening the macula in patients with congenital X-linked retinoschisis.
  • Kurihara T, Endo T, Obata S, Hotta T, Nishio N, Iwaibara T, Hirata K, Kuge S, Konishi Y, Yoshida D, Yanagi T, Taga T, Wada K, Wada N, Ohga S, Kusaka S.
    Am J Ophthalmol Case Rep. Elsevier BV 101854 - 101854 2451-9936 2023/04
  • 大久保 麻希, 坂本 万寿夫, 岩橋 千春, 日下 俊次
    あたらしい眼科 (株)メディカル葵出版 40 (3) 389 - 394 0910-1810 2023/03 
    目的:Vogt-小柳-原田病(以下,原田病)類似の眼病変で発症したメトトレキサート(MTX)関連リンパ増殖性疾患(MTX-LPD)の症例を報告する.症例:68歳,男性.両眼視力低下と眼瞼腫脹を自覚し眼科受診,初診時視力は右眼(0.15),左眼(0.2),両眼結膜浮腫,前房内炎症,脈絡膜肥厚,右眼漿液性網膜剥離を認めた.同時期より間欠性の発熱や頸部リンパ節腫脹などがみられたこと,血清sIL-2R 36,478U/ml,前房水IL-10/IL-6>1より,リンパ腫病変を疑い頸部リンパ節生検を施行した.びまん性大細胞型B細胞性リンパ腫であり,また,3年前に発症した関節リウマチに対して3ヵ月前よりMTXの内服が開始されていたことより,MTX-LPDと診断した.MTX休薬を行うも全身症状が悪化したため,初診2週間後よりR-CHOP療法を施行,治療開始4週間後には両眼とも視力(0.9)となり,眼炎症所見は速やかに改善した.しかし,4ヵ月後に中枢神経病変を認め,R-MPV療法を施行するも中枢神経病変増悪のため発症7ヵ月後に死亡した.経過中,眼所見の再発はみられなかった.結論:MTX-LPDに原田病類似の眼所見を伴う可能性がある.(著者抄録)
  • Özdek Ş, Özdemir Zeydanlı E, Baumal C, Hoyek S, Patel N, Berrocal A, Lopez-Cañizares A, Al-Khersan H, Kusaka S, Mano F, Jalali S, Lepore D, Akar S.
    Turk J Ophthalmol . Turkish Ophthalmological Association 53 (1) 44 - 57 2023/02 
    Avascular peripheral retina in an infant is a common characteristic of numerous pediatric retinal vascular disorders and often presents a diagnostic challenge to the clinician. In this review, key features of each disease in the differential diagnosis, from retinopathy of prematurity, familial exudative vitreoretinopathy, Coats disease, incontinentia pigmenti, Norrie disease, and persistent fetal vasculature, to other rare hematologic conditions and telomere disorders, will be discussed by expert ophthalmologists in the field.
  • Iwahashi C, Itami T, Sakamoto M, Kusaka S.
    Ocul Immunol Inflamm. 1 - 4 2023/02 
    PURPOSE: To report a case of bilateral retinal vasculitis successfully managed with adalimumab in a patient with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. CASE REPORT: SAPHO syndrome was diagnosed in a 48-year-old female with bilateral blurred vision refractory to steroid eye drops. A preliminary ophthalmic examination revealed bilateral intermediate uveitis with vitreous opacity, and fluorescein angiography (FA) revealed dye leakage from peripheral retinal vessels. Because oral antirheumatic drugs were ineffective in treating her osteitis, her internist prescribed adalimumab, which resulted in rapid normalization of C-reactive protein and improvement of osteitis. Following treatment with adalimumab for 5 months, FA revealed significant improvement of retinal vasculitis. This is the first report on the use of adalimumab for retinal vasculitis associated with SAPHO syndrome. CONCLUSION: We described a rare case of retinal vasculitis associated with SAPHO syndrome. Adalimumab treatment was effective in treating both osteitis and retinal vasculitis.
  • Ung C, Yonekawa Y, Chung MM, Berrocal AM, Kusaka S, Oshima Y, Chan RVP, Inoue M, Read SP, Kuriyan AE, Todorich B, Thanos A, Thomas BJ, Wolfe JD, Hassan TS, Capone A Jr.
    Retina Ovid Technologies (Wolters Kluwer Health) 43 (2) 238 - 242 0275-004X 2023/02
  • Eguchi H, Hotta F, Kusaka S.
    Int J Mol Sci . MDPI AG 24 (3) 2611 - 2611 2023/01 
    Smear microscopic examination and culture of the corneal scrapings are the gold standards for the diagnosis of bacterial keratoconjunctivitis. High-sensitivity molecular biological examinations of the ocular surface specimens are used clinically. However, the results require careful interpretation to avoid the unintentional detection of indigenous bacteria. Results of conventional and state-of-the-art examinations require clinical verification for specificity and sensitivity. In this study, smear microscopic examination, culture, and nanopore sequencing using the MinION of ocular surface specimens from eight clinically diagnosed bacterial keratoconjunctivitis cases were performed and compared. Seven of the eight cases (87.5%) were smear positive and five (62.5%) were culture positive. The former showed the same genus in >60% of the classified reads as one specific bacterium inferred from the smear microscopy when sequenced by the MinION. In two of the three culture-negative cases, the smear-positive images were highly reminiscent of the species comprising most of the MinION sequences. Four of the five culture-positive cases were consistent with the most prevalent bacteria in the sequencing results. Probable contamination among specimens processed on the same day were observed. In conclusion, the microscopic examination of the corneal scraping specimens may be more sensitive and specific than the culture examination. Additionally, although metagenomic analysis using the MinION contributes to more precise medication for bacterial keratoconjunctivitis, contamination can affect the results.
  • Long-term visual prognosis of patients following lens-sparing vitrectomy for stage 4A retinopathy of prematurity
    Iwahashi C, Kurihara T, Kuniyoshi K, Kusaka S.
    Int J Mol Sci. MDPI 24 (3) 論文番号2416  2023/01
  • Hsu HT, Kang EY, Blair MP, Shapiro M, Komati R, Hubbard BG, Price KW, Capone A Jr, Drenser KA, Trese MT, Shields R, Kondo H, Matsushita I, Yonekawa Y, Patel SN, Kusaka S, Mano F, Olsen KR, Ells A, Amphornphruet A, Walsh MK, Besirli CG, Moinuddin O, Baumal CR, Enriquez AB, Hwang YS, Lai CC, Wu WC.
    Ophthalmol Retina Elsevier 7 (1) 72 - 80 2023/01 [Refereed]
     
    PURPOSE: To investigate late vitreoretinal complications and visual outcomes in patients with regressed retinopathy of prematurity (ROP) with or without prior treatment. DESIGN: International, multicenter, noncomparative retrospective case series. PARTICIPANTS: We analyzed 264 eyes of 238 patients from 13 centers worldwide who developed vitreoretinal complications (retinal detachment [RD], vitreous hemorrhage [VH], or retinal break) ≥ 2 years after resolution of acute ROP. METHODS: Each participant was assigned to 1 of 3 groups (the RD, VH, and retinal break groups) according to their primary diagnosis. The average age at presentation, visual acuities, refractive error, axial length, gestational age, birth weight, acute ROP classification, prior treatments for acute ROP, postoperative visual acuity (VA), and concomitant eye conditions in the 3 groups were documented and compared. MAIN OUTCOME MEASURES: Clinical features and visual outcomes of late vitreoretinal complications in patients with regressed ROP. RESULTS: A total of 264 eyes of 238 patients were included. The prior acute ROP status was comparable among the 3 groups, except that the VH group had a higher proportion of patients with type 1 ROP (P = 0.03) and prior treatment (P < 0.001) than the other groups. The average age at presentation was earlier in the RD (20.3 ± 15.5 years) and VH (21.4 ± 18.9 years) groups than in the retinal break group (31.9 ± 18.2 years; P < 0.001). The retinal break group had the best presenting best-corrected VA, followed by the RD and VH groups (P < 0.001). Surgical intervention improved VA in both the RD and VH groups (both P < 0.05). The overall trend of VA was the most favorable in the retinal break group, followed by that in the VH and RD groups. Cicatricial changes in the fellow retina were observed in > 90% of patients with unilateral involvement. CONCLUSIONS: Infants with acute ROP remain at a high risk of vision-threatening complications throughout childhood and adulthood. Continual follow-up of patients with ROP is important. When severe complications, such as RD or VH, are detected, timely surgical intervention is necessary to ensure favorable visual outcomes in these patients.
  • Kusaka S, as a member of Retinopathy of Prematurity Injection Consortium.
    Ophthalmology Elsevier BV 129 (12) 1380 - 1388 0161-6420 2022/12
  • 硝子体内注射後に発症した表皮ブドウ球菌による眼内炎に対し硝子体手術を施行した未熟児網膜症の1例
    黒木 迪子, 杉田 直大, 今里 美幸, 梶原 夏輝, 日高 貴子, 高田 真知, 福島 慶美, 柊山 剰, 日下 俊次, 中馬 秀樹, 池田 康博
    眼科臨床紀要 眼科臨床紀要会 15 (11) 721 - 726 2022/11
  • Mano F, Yonekawa Y, Kakihara S, Fortun J, Borrelli E, Bandello F, Murata T, Kusaka S, Dispenzieri A, Pulido JS.
    Retina Ovid Technologies (Wolters Kluwer Health) 42 (10) 1989 - 1994 0275-004X 2022/10 
    PURPOSE: To characterize choroidal amyloid angiopathy (CAA) using late-phase indocyanine green angiography (ICGA). METHODS: This was a multicenter retrospective observational case series on patients with transthyretin (ATTR) and AL amyloidosis who underwent ICGA. The timing of hyperfluorescence and longitudinal changes were analyzed. RESULTS: Thirty-two patients (27 with ATTR and 5 with AL) with mean age of 58.9 ± 17.4 years were included. Hyperfluorescent spots in the very late phases of ICGA, corresponding to CAA, were observed in 49 of 55 eyes (89%). The median time to maximal staining was 672 (95% confidence interval, 644-752) seconds, which was significantly later than the initial staining (503 [95% confidence interval, 447-521], P < 0.0001; Wilcoxon signed rank test). In seven patients with ATTR amyloidosis who underwent follow-up of ICGA, the CAA was stable in two patients and improved in five patients during treatment. However, 3 patients (43%) had worsening vitreous opacities in both eyes, and 4 patients (57%) developed secondary open-angle glaucoma. CONCLUSION: Most patients with amyloidosis were found to have CAA on ICGA. Up to 12.5 minutes is required for maximal ICG staining. Choroidal amyloid angiopathy improved in most patients with systemic treatment and may serve as a marker of systemic disease status.
  • Mano F, Iwahashi C, Kuniyoshi K, Kusaka S.
    Retina Ovid Technologies (Wolters Kluwer Health) 42 (10) 1950 - 1957 0275-004X 2022/10 
    PURPOSE: This study investigated the outcomes of vitrectomy for Stage 5 retinopathy of prematurity (ROP) based on the International Classification of Retinopathy of Prematurity third edition, in which Stage 5 ROP is divided into three subgroups. METHODS: Fifty-four eyes of 34 patients with Stage 5 ROP who underwent vitrectomy between 2004 and 2020 were retrospectively analyzed. Data including sex, gestational age and weight at birth, International Classification of Retinopathy of Prematurity 3 subcategories, perioperative use of intravitreal bevacizumab injection and laser photocoagulation, surgical procedure and complications, final retinal reattachment, and follow-up period were collected. RESULTS: Complete retinal reattachment was achieved in 16 eyes (88.9%) with Stage 5A and 13 eyes (39.4%) with Stage 5B ( P = 0.0003, Wilcoxon rank-sum test). Three patients with Stage 5C were considered inoperable. Postoperative anatomical failure was significantly associated with stage (Stage 5B vs. 5A; odds ratio, 17.986; 95% confidence interval, 3.712-148.502; P = 0.0001, multivariate logistic regression analysis). Intraoperative intravitreal bevacizumab was significantly associated with lower postoperative incidence of vitreous hemorrhage and glaucoma ( P = 0.041, chi-square test). CONCLUSION: Staging of preoperative anatomical features based on International Classification of Retinopathy of Prematurity 3 is a useful predictor for final anatomical success. Intraoperative intravitreal bevacizumab might reduce postoperative complication risks.
  • Ishibashi T, Matsumoto C, Nomoto H, Tanabe F, Narita I, Ishibashi M, Okuyama S, Kayazawa T, Kimura S, Yamanaka K, Kusaka S.
    Transl Vis Sci Technol . Association for Research in Vision and Ophthalmology (ARVO) 11 (8) 26 - 26 2164-2591 2022/08
  • Kusaka S, as a member of FIREFLEYE Study Group.
    JAMA American Medical Association (AMA) 328 (4) 348 - 359 0098-7484 2022/07
  • Visual snow syndromeの2例
    田村 佳菜子, 國吉 一樹, 堀田 芙美香, 松本 長太, 日下 俊次
    臨床眼科 (株)医学書院 76 991 - 996 2022/07
  • Kusaka S, as a member of Collaborative Community in Ophthalmic Imaging Executive Committee and the Collaborative Community in Ophthalmic Imaging Retinopathy of Prematurity Workgroup.
    Ophthalmology Elsevier BV 129 (7) e69 - e76 0161-6420 2022/07 [Refereed]
  • Kusaka S, as a member of this study group organized by Japan Retina and Vitreous Society.
    Br J Ophthalmol BMJ bjophthalmol - 2022 0007-1161 2022/06 
    Background/aims To determine the incidence and causative pathogens of endophthalmitis after vitrectomy during strict face mask wearing in the COVID-19 period. Methods This was a retrospective multicentre study including 31 ophthalmological institutions of the Japanese Retina and Vitreous Society or Japan-Clinical Retina Study group. Patients who had undergone vitrectomy during 2019, the pre-COVID-19 period, and from July 2020 to June 2021, the COVID-mask period, were studied. The results of cataract surgery were used as a control. The total number of vitrectomies and the total number of postoperative endophthalmitis were determined. Then, the differences in the incidence of postoperative endophthalmitis between the pre-COVID-19 period and the COVID-mask period, and the type of pathogens causing the endophthalmitis were studied. Results The incidence of postvitrectomy endophthalmitis was significantly lower in the pre-COVID-19 period with 16 568 surgeries and 18 endophthalmitis cases (0.11%) than in the COVID-mask period of 14 929 surgeries and 31 endophthalmitis cases (0.21%; p=0.031, OR=1.913, 95% CI 1.078 to 3.394). In the pre-COVID-19 period, 4 of the 18 eyes were culture positive, and all were of the Staphylococcus family. In the COVID-mask period, 9 of the 31 eyes were culture positive, and 4 cases were related to oral commensals including Streptococcus spp, which are reportedly very rare in endophthalmitis after vitrectomy. Conclusions It is necessary for physicians to be aware of the higher incidence of postvitrectomy endophthalmitis during the COVID-mask period, and to treat their patients appropriately.
  • Kusaka S, as a member of ICROP 3 Classification Committee.
    J AAPOS Elsevier BV 26 (3) 109 - 112 1091-8531 2022/06
  • Sugioka K, Nishida T, Kodama-Takahashi A, Murakami J, Mano F, Okada K, Fukuda M, Kusaka S.
    Am J Physiol Cell Physiol AM. PHYSIOLOGICAL SOCIETY 323 (1) 104 - 115 2022/06 
    Corneal fibroblasts are embedded within an extracellular matrix composed largely of collagen type 1, proteoglycans, and other proteins in the corneal stroma, and their morphology and function are subject to continuous regulation by collagen. During wound healing and in various pathological conditions, corneal fibroblasts differentiate into myofibroblasts characterized by the expression of α-smooth muscle actin (α-SMA). Endo180, also known as urokinase-type plasminogen activator (uPA) receptor-associated protein (uPARAP), is a collagen receptor. Here we investigated whether targeting of Endo180 and the uPA receptor (uPAR) by uPA might play a role in the regulation of α-SMA expression by culturing corneal fibroblasts derived from uPA-deficient (uPA-/-) or wild-type (uPA+/+) mice in a collagen gel or on plastic. The expression of α-SMA was upregulated, the amounts of full-length Endo180 and uPAR were increased, and the levels of both transforming growth factor-b (TGF-β) expression and Smad3 phosphorylation were higher in uPA-/- corneal fibroblasts compared with uPA+/+ cells under the collagen gel culture condition. Antibodies to Endo180 inhibited these effects of uPA deficiency on a-SMA and TGF-b expression, whereas a TGF-b signaling inhibitor blocked the effects on Smad3 phosphorylation and a-SMA expression. Our results suggest that uPA deficiency might promote the interaction between collagen and Endo180 and thereby increase a-SMA expression in a manner dependent on TGF-β signaling. Expression of α-SMA is thus negatively regulated by uPA through targeting of Endo180 and uPAR.
  • Kishimoto T, Ishida W, Nakajima I, Taguchi O, Sugioka K, Kusaka S, Fukuda K.
    Exp Eye Res . Elsevier BV 218 108980 - 108980 0014-4835 2022/05
  • Kondo C, Iwahashi C, Utamura S, Kuniyoshi K, Konishi Y, Wada N, Kawasaki R, Kusaka S.
    Front Pediatr Frontiers Media SA 10 785292 - 785292 2022/04 [Refereed]
     
    Background: We investigated the incidence and clinical characteristics of eyes showing retinal detachment (RD) after anti-vascular endothelial growth factor (VEGF) for retinopathy of prematurity (ROP). Methods: A retrospective chart review of 76 consecutive eyes of 45 patients (18 girls and 27 boys) with stage 3 ROP who received anti-VEGF therapy between January 2012 and August 2020 with a minimum follow-up of 6 months was conducted. Eyes were divided into two groups: the vitrectomy (V) group that required vitrectomy for RD after anti-VEGF therapy and the non-vitrectomy (non-V) group that did not require vitrectomy. Data were collected from patient charts, including sex, postmenstrual age (PMA) at birth, birth weight, PMA at anti-VEGF therapy, comorbidities, reactivation, examination interval, and subsequent vitrectomies. Results: The median PMA at birth was 24.7 (range, 22.1-29.3) weeks. Twenty-seven eyes (35.1%) exhibited ROP reactivation at 6.4 ± 3.1 weeks after anti-VEGF therapy. The V group included six eyes of five patients, all of whom exhibited reactivation and developed RD 10.1 ± 6.5 weeks after anti-VEGF therapy. The types of RD were conventional (classic) in two eyes and circumferential (unique to RD after anti-VEGF) in four eyes. Three eyes required repeated vitrectomy. All eyes, except one eye in the V group, achieved retinal attachment at the last examination. The non-V group included 70 eyes of 40 patients, of which 21 exhibited reactivation and were treated successfully with laser (17 eyes) or second anti-VEGF (4 eyes). The proportion of eyes with plus disease was significantly higher in the V group (50.0%) than in the non-V group (10.0%) (P = 0.035). V group included 3 of 22 eyes (13.6%) in which the interval between the last examination and the diagnosis of reactivation was <1 week and 3 of 5 eyes (60.0%) in which the interval was more than 1 week (P = 0.024). The two groups showed no significant differences in the other factors. Conclusion: Approximately 8% of eyes developed RD about 10 weeks after anti-VEGF therapy for ROP. Eyes with history of plus disease should be carefully monitored at appropriate intervals after anti-VEGF therapy for ROP.
  • Narita I, Wakayama A, Shiraishi Y, Tanabe F, Kusaka S.
    Graefes Arch Clin Exp Ophthalmol. Springer 260 (4) 1395 - 1404 2022/04 
    PURPOSE: To investigate the effects of orthoptic training for residual diplopia after blowout fracture (BOF) surgery. METHODS: We retrospectively reviewed the medical records of 14 (average age, 22.9 ± 13.1 years) patients with residual diplopia, who had undergone orthoptic training after BOF surgery at the Department of Ophthalmology, Kindai University Hospital, between August 2013 and September 2019. The orthoptic training included exercises for eye movement, convergence, and fusional area expansion. We assessed the training effects by scoring patients' Hess screen (Hess) test results and fields of binocular single vision (BSV). The scores obtained before/after surgery and after training were compared. We also investigated the factors that influenced patients' BSV scores after training. p < 0.05 was considered statistically significant. RESULTS: The respective pre- and postoperative and after-training average scores were 7.0 ± 5.3, 5.4 ± 4.3, and 2.5 ± 3.2 points for Hess and 50.0 ± 41.3, 48.2 ± 35.9, and 89.4 ± 14.0 points for BSV. Neither Hess nor BSV score showed a significant difference before and after surgery (p > 0.05, the Steel-Dwass test). Compared to the postoperative (i.e., before training) scores, both Hess and BSV scores significantly improved after training (p < 0.05 for Hess, p < 0.01 for BSV; the Steel-Dwass test). CONCLUSION: Orthoptic training appeared effective in resolving residual diplopia after BOF surgery by improving patients' ocular motility and expanding the BSV field.
  • Pars plana vitrectomy for vitreoretinal complications in only seeing eyes after treatment for retinoblastoma
    Nishida K, Morimoto T, Suzuki S, Iwahashi C, Imai H, Kuniyoshi K, Kusaka S.
    Am J Ophthalmol Case Rep . Elsevier Inc. 25 Article 101367  2022/03
  • Sato T, Kuniyoshi K, Kodama T, Kusaka S.
    Am J Ophthalmol Case Rep. Elsevier BV 26 101416 - 101416 2451-9936 2022/02
  • Kayazawa T, Kuniyoshi K, Hatsukawa Y, Fujinami K, Yoshitake K, Tsunoda K, Shimojo H, Iwata T, Kusaka S.
    Ophthalmic Genet. Informa UK Limited 43 (3) 400 - 408 1381-6810 2022/01 
    Leber congenital amaurosis (LCA), although rare, is one of the most severe forms of early-onset inherited retinal dystrophy (IRD). Here, we review the molecular genetics and phenotypic characteristics of patients with NMNAT1-associated IRD. The longitudinal clinical and molecular findings of a Japanese girl diagnosed with LCA associated with pathogenic variants in NMNAT1 c.648delG, (p.Trp216Ter*) and c.709C>T (p.Arg237Cys) have been described to highlight the salient clinical features of NMNAT1-associated IRD.
  • Mano F, Sugioka K, Kuniyoshi K, Kondo H, Kusaka S.
    BMC Ophthalmology Springer Science and Business Media LLC 22 (1) 14 - 14 2022/01 
    Abstract Background This case report describes the surgical outcome in a patient with congenital X-linked retinoschisis (CXLRS) and the results of proteomic analysis of surgically extracted samples from both vitreous and intraschisis cavities by mass spectrometry. Case presentation A 3-month-old boy presented with extensive retinoschisis involving macula and retinal periphery in both eyes. Genetic analysis confirmed retinoschisin 1 mutation (c.554C > T), and an electroretinogram showed significant reduction of b-wave and decreased cone and rod responses, which led to a diagnosis of CXLRS. By performing pars plana vitrectomy, including inner wall retinectomy, clear visual axes with stable retinal conditions and functional vision in both eyes were obtained during the 4 years of follow-up. Proteomic analysis of surgically retrieved fluid from the intraschisis cavity revealed a higher expression of interphotoreceptor retinoid-binding protein (IRBP) than that from the vitreous humor. However, both samples showed equal levels of albumin, transferrin, and pigment epithelium-derived factor. Conclusions Cellular adhesive imperfection in CXLRS may cause IRBP diffusion from the interphotoreceptor matrix, resulting in the strong expression of IRBP in the intraschisis cavity. An impaired retinoid cycle caused by an absence of IRBP in the retina may potentially underlie the pathology of CXLRS.
  • 日本人enhanced S-cone syndromeの臨床的および遺伝学的特徴
    林 孝彰, 溝渕 圭, 亀谷 修平, 國吉 一樹, 日下 俊次, 上野 真治, 西口 康二, 三宅 養三, 中野 匡.
    日本眼科学会雑誌 (公財)日本眼科学会 126 (1) 7 - 18 0029-0203 2022/01 [Refereed]
     
    目的:Enhanced S-conesyndrome(ESCS)は網膜電図(ERG)でshort-wavelength-sensitive(S)錐体応答が増大する遺伝性網膜疾患であるが,網膜機能の進行性についてははっきりしていない.日本人ESCS症例に関して,ERGを含む長期臨床経過および遺伝学的特徴について後ろ向きに検討する.対象と方法:ESCSと診断された9例を対象とし,このうち8例の初期臨床像は過去に報告されている.NR2E3遺伝子変異はSanger法で決定された.視力,光干渉断層計を用いた中心窩網膜厚,ERG所見について検討した.結果:初発症状を聴取できた7例は,就学前に夜盲を自覚していた.各施設の初診時平均年齢は36.2歳,平均観察期間は15.0年であった.初診時に視力不良であったほうの眼の視力は経過中に大きく変化していなかった.最終測定時の平均中心窩網膜厚は初回測定時に比べ有意に減少していた.特徴的全視野ERGおよびS錐体ERG所見は全例で観察された.20年以上の長期経過を追えた2例の錐体応答は明らかに減弱していた.全例でNR2E3遺伝子に両アレル変異が検出され,p.Arg104Gln変異が28%(5/18アレル)と最多であった.結論:ERGの結果から,ESCSは進行性の網膜変性疾患であることが確認できた.視力は黄斑部網膜分離を合併しなければ比較的長期にわたり維持される可能性がある.p.Arg104Gln変異が日本人ESCSの主要変異であると考えられた.(著者抄録)
  • Wood EH, Capone A Jr, Drenser KA, Berrocal A, Hubbard GB, Callaway NF, Kychenthal A, Ells A, Harper CA 3rd, Besirli CG, Baumal CR, Vavvas DG, Chang EY, Nudleman ED, Tsui I, Sears J, Vajzovic L, Hartnett ME, Shapiro MJ, Quiram PA, Ozdek S, Kusaka S, Wu WC, Trese MT.
    Ophthalmic Surg Lasers Imaging Retina. SLACK, Inc. 53 (1) 3 - 6 2325-8160 2022/01
  • Tachibana K, Maeda N, Abe K, Kusaka S.
    J Cataract Refract Surg . 47 (11) 1417 - 1422 2021/11 
    PURPOSE: To compare the outcomes of intraocular lens (IOL) implantation using toric (T)-IOL and nontoric (N)-IOL in pediatric cataract patients with astigmatism and to examine the effect of optic capture (OC) on the axis misalignment (AM) of the T-IOLs. SETTING: Department of Ophthalmology, Kindai University Hospital, Osaka, Japan. DESIGN: Interventional, comparative case study. METHODS: Consecutive pediatric patients implanted with T-IOLs or N-IOLs were retrospectively reviewed. In the T-IOL group, the preoperative and postoperative corrected distance visual acuity (CDVA) and AM were compared in patients with and without OC. RESULTS: The T-IOL group included 14 eyes of 11 patients, whereas the N-IOL group included 22 eyes of 15 patients. One year postoperatively, the mean ocular cylinder (1.38 ± 0.80 diopters [D]) was significantly smaller than the mean corneal cylinder (3.33 ± 1.24 D) in the T-IOL group (P = .00012, Wilcoxon signed-rank test). The mean preoperative and 1-year postoperative CDVA (logMAR) were 0.57 and 0.003 (T-IOL) and 0.71 and 0.09 (N-IOL), respectively. The AM at 1 week and 1 year postoperatively was 2.6 ± 3.7 degrees and 4.4 ± 3.1 degrees for the OC group, and 13.3 ± 8.8 degrees and 18.5 ± 14.8 degrees, for the non-OC group, respectively. The AM was significantly smaller in the OC group than that in the non-OC group (P = .009, Mann-Whitney U test) at postoperative 1 week. CONCLUSIONS: T-IOL implantation is effective in correcting astigmatism in pediatric cataract patients with astigmatism, and the OC technique is likely to achieve lower AM of the T-IOL.
  • Iwahashi C, Utamura S, Kuniyoshi K, Sugioka K, Konishi Y, Wada N, Kusaka S.
    Retina Ovid Technologies (Wolters Kluwer Health) 41 (11) 2261 - 2268 0275-004X 2021/11 
    PURPOSE: To investigate the efficacy and risk factors of intravitreal anti-vascular endothelial growth factor injection (anti-VEGF therapy) for retinopathy of prematurity (ROP). METHODS: We retrospectively reviewed 80 consecutive eyes of 43 patients with type 1 ROP or worse who received anti-VEGF therapy during January 2012-February 2018. Patients were divided into those who were injected with 0.25 mg bevacizumab (IVB group, 37 eyes) and 0.25 mg ranibizumab (IVR group, 43 eyes). Serum VEGF concentrations of 18 patients were measured before and after IVR. RESULTS: Anti-VEGF therapy reduced ROP activity in all eyes; however, 14 eyes (17.5%) exhibited reactivation. The reactivation rates of the IVB and IVR groups were 13.5% and 20.9%, respectively (p = 0.556). Multivariate logistic regression analysis showed that postmenstrual age (PMA) ≤35 weeks at anti-VEGF therapy (p = 0.014) and aggressive posterior ROP (p = 0.044) were significantly associated with reactivation. Serum VEGF was significantly suppressed at days 1 (p < 0.001) and 7 (p = 0.012) after IVR and returned to preinjection level by day 14 (p = 0.210). CONCLUSIONS: Both IVR and IVB seemed effective in reducing ROP activity. Reactivation after anti-VEGF therapy may be associated with younger PMA at anti-VEGF therapy and aggressive posterior ROP.
  • Tachibana K, Maeda N, Abe K, Kusaka S.
    J Cataract Refract Surg. Ovid Technologies (Wolters Kluwer Health) 47 (11) 1417 - 1422 0886-3350 2021/11
  • Iwahashi C, Tachibana K, Oga T, Kondo C, Kuniyoshi K, Kusaka S.
    Ophthalmol Retina Elsevier BV 5 (11) 1139 - 1145 2468-6530 2021/11 
    PURPOSE: To determine the incidence and factors associated with lens opacity after lens-sparing vitrectomy (LSV) for retinopathy of prematurity (ROP). DESIGN: Retrospective comparative case series. PARTICIPANTS: Among the 141 eyes of 94 patients who received LSV for ROP between 2006 and 2019, 108 eyes of 71 patients with minimum follow-up of 12 months after LSV were investigated. METHODS: Data were collected from patients' charts, including sex, gestational age at birth, birth weight, stage of ROP, postmenstrual age (PMA) at LSV, surgical procedure, preoperative injection of anti-vascular endothelial growth factor (anti-VEGF), subsequent retinal surgeries, and lensectomy during the follow-up. MAIN OUTCOME MEASURES: Lens status at last visit, incidence and timing of lensectomy, risk factors for lens opacity requiring lensectomy. RESULTS: Stages of ROP at LSV were 4A, 4B, and 5 in 92, 13, and 3 eyes, respectively. The median PMA at LSV was 40.6 weeks. Thirty-two eyes received anti-VEGF therapy prior to LSV. Lens opacity was found in 17 eyes (15.7%), of which 10 eyes (9.3%) underwent lensectomy. The period between LSV and lensectomy ranged from 21 days to 131.9 months (median: 21.1 months). Eleven other eyes (10.2%) underwent lensectomy as part of a reoperation for worsening of ROP. A total of 80 eyes (74.1%) preserved clear lenses at the latest follow-up examination after surgery (median: 6.8 years; range: 1-14 years). The Kaplan-Meier estimate showed that the proportion of patients with phakia at 5 and 10 years was 92.4% and 89.0%, respectively. Multivariate Cox regression analysis revealed that eyes with the use of tamponade at LSV (p = 0.005; odds ratio: 25.68; confidence interval: 4.187-157.5) and young PMA at LSV (p = 0.033; odds ratio: 1.047; confidence interval: 1.012-1.099) were significantly associated with lens opacity requiring lensectomy. However, anti-VEGF therapy was not associated with lens opacity requiring lensectomy. CONCLUSIONS: Nearly 10% of eyes required lensectomy due to lens opacity after LSV for ROP. The development of lens opacity requiring lensectomy appears to be associated with the use of tamponade and young PMA at LSV.
  • 血管新生緑内障をきたした小児網膜中心静脈閉塞症
    竹内 正興, 千原 智之, 嶋 千絵子, 盛 秀嗣, 大中 誠之, 日下 俊次, 高橋 寛二
    臨床眼科 (株)医学書院 75 (10) 1344 - 1350 2021/10
  • Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A.
    Ophthalmology. Elsevier BV 128 (10) e51 - e68 0161-6420 2021/10
  • Mano F, Matsushita I, Kondo H, Utamura S, Kondo C, Kusaka S.
    Sci Rep. Springer Science and Business Media LLC 11 (1) Article 19333 - 19333 2021/09 
    AbstractThis study investigated the surgical outcomes of Coats disease and the role of external drainage (XD) of subretinal fluid (SRF). The study is a multicenter retrospective interventional case series of 26 consecutive eyes of 26 patients who underwent surgeries for advanced Coats disease with retinal detachment. Main outcomes measured were: 1) comparison of complete SRF resolution with or without XD, and 2) variables that were associated with functional postoperative best-corrected visual acuity (BCVA) defined as BCVA of 0.1 or better, 3) intraocular vascular endothelial growth factor (VEGF) levels. Complete SRF resolution was achieved in all 14 eyes in which XD had been performed and in 75% of 12 eyes in which XD had not been performed (P = .03). Multivariable logistic regression analysis revealed that initial BCVA was the only variable associated with functional postoperative BCVA (odds ratio 3.24, 95% CI 0.93–11.33; P = .04). Markedly elevated VEGF levels were noted in the SRF compared with those in the vitreous humor (49,760 ± 52,990 vs. 707 ± 611 pg/mL, P = .03). XD seems to provide better anatomical success than without XD in the treatment of advanced Coats disease as XD could effectively eliminate substantial amount of VEGF in the SRF.
  • Takada R, Matsumoto F, Wakayama A, Numata T, Tanabe F, Abe K, Kusaka S.
    BMC Ophthalmol Research Square Platform LLC 21 (1) Article number: 304  2021/08 
    Abstract Purpose: The efficacies of prism adaptation test (PAT) and monocular occlusion (MO) and their optimal test durations to detect the maximum angles of deviation at near and distance in eyes with intermittent exotropia (IXT) were assessed and compared. Methods: We retrospectively reviewed the medical records of 72 patients with IXT, who had undergone the initial strabismus surgery between April 2015 and October 2018 and had been preoperatively tested by PAT and MO. The near and distance deviations measured after 30- and 60-minute PAT and MO were compared with the baseline measurements obtained immediately after prism wear and before occlusion. The measurements and the required durations for obtaining the maximum deviation angle were also compared between PAT and MO. Results: Compared with the baseline, the near deviation by PAT significantly increased after 30 (p < 0.05) and 60 (p < 0.01) minutes but not the distance deviation. Besides, the increase in the near deviation after 30 minutes was not significant. By MO, neither near nor distance deviation showed a significant difference from the baseline after 30 and 60 minutes. While the near deviations by PAT were significantly greater than those by MO at 30 and 60 minutes, a similar result was only observed at 30 minutes in the distance deviation. Conclusion: A 30-minute PAT appears to be more effective than MO in revealing the maximum angle of deviation before strabismus surgery.
  • Imamura H, Eguchi H, Sakamoto M, Hotta F, Tabuchi H, Kusaka S.
    Front Med. Frontiers Media SA 8 2021/08 
    Background: Rebamipide ophthalmic suspension was launched in Japan in 2012 and is used for the treatment of dry eye. Case Presentation: We report two cases of orbital abscess, which resulted from dacryocystitis that occurred after administration of rebamipide ophthalmic suspension. Computed tomography images showed an eyeball deformity in one case and exophthalmos in the other. In both cases, light microscopy, scanning electron microscopy and energy dispersive X-ray examinations revealed lacrimal sac concretions, which contained calcium phosphate crystals that were surrounded by microorganisms. Lacrimal sac concretion removal from the lacrimal sacs during dacryocystorhinostomies was performed on both patients. Although the postoperative outcome was favorable in one case, vision was lost in the other case due to the development of retinal artery occlusion as a complication of the orbital abscess, despite lacrimal sac concretion removal and administration of antimicrobials. Conclusions: This is the first case report to highlight that rebamipide ophthalmic suspension can cause an orbital abscess via development of lacrimal sac concretion. Ophthalmologists should be aware that rebamipide ophthalmic suspension might induce the formation of concretion in the lacrimal sac.
  • Tachibana K, Abe K, Kusaka S, Maeda N.
    J Cataract Refract Surg. Ovid Technologies (Wolters Kluwer Health) 47 (8) 1108 - 1108 0886-3350 2021/08
  • Rossin EJ, Tsui I, Wong SC, Hou KK, Prakhunhungsit S, Blair MP, Shapiro MJ, Leishman L, Nagiel A, Lifton JA, Quiram P, Ringeisen AL, Henderson RH, Arruti N, Buzzacco DM, Kusaka S, Ferrone PJ, Belin PJ, Chang E, Hubschman JP, Murray TG, Leung EH, Wu WC, Olsen KR, Harper CA 3rd, Rahmani S, Goldstein J, Lee T, Nudleman E, Cernichiaro-Espinosa LA, Chhablani J, Berrocal AM, Yonekawa Y.
    Ophthalmol Retina. Elsevier BV 5 (8) 805 - 814 2468-6530 2021/08
  • Huang YP, Basanta H, Kang EY, Chen KJ, Hwang YS, Lai CC, Campbell JP, Chiang MF, Chan RVP, Kusaka S, Fukushima Y, Wu WC.
    Br J Ophthalmol. BMJ 105 (8) 1099 - 1103 0007-1161 2021/08 [Refereed]
     
    Background/Aim To automatically detect and classify the early stages of retinopathy of prematurity (ROP) using a deep convolutional neural network (CNN). Methods This retrospective cross-sectional study was conducted in a referral medical centre in Taiwan. Only premature infants with no ROP, stage 1 ROP or stage 2 ROP were enrolled. Overall, 11 372 retinal fundus images were compiled and split into 10 235 images (90%) for training, 1137 (10%) for validation and 244 for testing. A deep CNN was implemented to classify images according to the ROP stage. Data were collected from December 17, 2013 to May 24, 2019 and analysed from December 2018 to January 2020. The metrics of sensitivity, specificity and area under the receiver operating characteristic curve were adopted to evaluate the performance of the algorithm relative to the reference standard diagnosis. Results The model was trained using fivefold cross-validation, yielding an average accuracy of 99.93%±0.03 during training and 92.23%±1.39 during testing. The sensitivity and specificity scores of the model were 96.14%±0.87 and 95.95%±0.48, 91.82%±2.03 and 94.50%±0.71, and 89.81%±1.82 and 98.99%±0.40 when predicting no ROP versus ROP, stage 1 ROP versus no ROP and stage 2 ROP, and stage 2 ROP versus no ROP and stage 1 ROP, respectively. Conclusions The proposed system can accurately differentiate among ROP early stages and has the potential to help ophthalmologists classify ROP at an early stage.
  • 斑状の黄斑変性を合併し夜盲をきたした先天網膜分離症の1例
    永江 由季, 國吉 一樹, 林 孝彰, 近藤 千桜里, 亀谷 修平, 岩田 岳, 日下 俊次.
    眼科臨床紀要 眼科臨床紀要会 14 (7) 442 - 447 1882-5176 2021/07 
    背景:先天網膜分離症の典型例では車軸状黄斑変性を認めるが、その他にみられる眼底所見は多彩で、末期には非特異的網膜変性を示す。本報では、夜盲を伴い、斑状の黄斑変性を示した先天網膜分離症の1例を報告する。症例:初診時46歳の男性。30歳代半ばから進行性の夜盲を自覚し、視力が低下してきた。初診時の視力は、右(0.3)、左(0.2)で、黄斑部には黄色斑が集簇していたが、黄斑部網膜分離はなかった。眼底自発蛍光検査では黄斑部はモザイク状の低蛍光を示した。杆体網膜電図electroretinogram(ERG)は消失し、フラッシュERGはnegative型であった。暗順応検査では約1 logの閾値上昇を認めた。RS1遺伝子を検索したところ、既知変異p.Arg200Cysが発見された。結論:本症例にみられた斑状の黄斑変性は先天網膜分離症としては非典型的で、確定診断に遺伝子検索が有用であった。(著者抄録)
  • Kondo H, Matsushita I, Nagata T, Fujihara E, Hosono K, Uchio E, Hotta Y, Kusaka S.
    Transl Vis Sci Technol. Association for Research in Vision and Ophthalmology (ARVO) 10 (7) Article 18  2164-2591 2021/06
  • 小児無水晶体眼症例に処方したハードコンタクトレンズのベースカーブと度数の変化
    立花 都子, 宮本 裕子, 月山 純子, 日下 俊次, 下村 嘉一
    日本コンタクトレンズ学会誌 日本コンタクトレンズ学会 63 (2) 36 - 40 2021/06
  • Yamao S, Tsujioka D, Takada R, Matsumoto F, Kusaka S.
    Retina. Ovid Technologies (Wolters Kluwer Health) 41 (6) 1338 - 1345 0275-004X 2021/06
  • Moysidis SN, Koulisis N, Adrean SD, Charles S, Chetty N, Chhablani JK, Cortes JC, Embabi SN, Gordon C, Gregori NZ, Habib A, Hamza H, Hassaan H, Hassan TS, Houghton O, Kadonosono K, Kusaka S, La Mantia A, Lai CC, Lumi X, Maeno T, Mahgoub MM, Mohamed El Baha S, Morales-Cantón V, Nowara M, Okonkwo ON, Parolini B, Rezende FA, Rogalinska I, Rojas S, Steel DH, Stopa M, Wu AL, Yamada K, Yamada M, Mahmoud TH.
    Ophthalmology. Elsevier BV 128 (5) 672 - 685 0161-6420 2021/05
  • Mano F, Dispenzieri A, Kusaka S, Pavesio C, Khalid H, Keane PA, Pulido JS.
    Retina Ovid Technologies (Wolters Kluwer Health) 41 (5) 1037 - 1046 0275-004X 2021/05 [Refereed]
     
    PURPOSE: This study aimed to describe the choroidal features of ocular amyloidosis using multimodal imaging, to correlate these findings with systemic involvement, and to propose a choroidal grading system. METHODS: Eleven patients with systemic amyloidosis were reviewed retrospectively. Each case was assigned a grade according to the severity of choroidal findings as determined by both enhanced depth imaging optical coherence tomography (EDI-OCT) and indocyanine green angiography (ICGA). The severity of systemic amyloidosis was then correlated to the choroidal involvement. RESULTS: On ICGA, all patients exhibited hyperfluorescent spots in the late stage and were classified according to pre-existing criteria. On EDI-OCT, hyperreflective foci were seen in the choriocapillaris and Sattler's layer in grade 1, partial loss of Sattler's layer was additionally seen in grade 2, and a dense hyperreflective Haller's layer was seen in grade 3. Choroidal grading scores were significantly correlated with systemic severity score (p=0.0014, Pearson's correlation co-efficient; ρ=0.83). CONCLUSION: With ocular amyloidosis, evaluation of choroidal characteristics using multimodal imaging may serve as a biomarker for systemic involvement.
  • Sugioka K, Fukuda K, Nishida T, Kusaka S.
    Exp Eye Res. Elsevier BV 204 0014-4835 2021/03 
    The cornea is a relatively unique tissue in the body in that it possesses specific features such as a lack of blood vessels that contribute to its transparency. The cornea is supplied with soluble blood components such as albumin, globulin, and fibrinogen as well as with nutrients, oxygen, and bioactive substances by diffusion from aqueous humor and limbal vessels as well as a result of its exposure to tear fluid. The healthy cornea is largely devoid of cellular components of blood such as polymorphonuclear leukocytes, monocytes-macrophages, and platelets. The location of the cornea at the ocular surface renders it susceptible to external insults, and its avascular nature necessitates the operation of healing and defense mechanisms in a manner independent of a direct blood supply. The fibrinolytic system, which was first recognized for its role in the degradation of fibrin clots in the vasculature, has also been found to contribute to various biological processes outside of blood vessels. Fibrinolytic factors thus play an important role in biological defense of the cornea. In this review, we address the function of the fibrinolytic system in corneal defense including wound healing and the inflammatory response.
  • Fujimoto K, Nagata T, Matsushita I, Oku K, Imagawa M, Kuniyoshi K, Hayashi T, Kimoto K, Ohji M, Kusaka S, Kondo H.
    Retina (Philadelphia, Pa.) 41 (3) 638 - 645 2021/03 [Refereed]
     
    PURPOSE: To determine the characteristics of fundus autofluorescence (FAF) images and visual functions in eyes with Stickler syndrome using ultra-widefield FAF images. METHODS: Forty-six eyes of 26 patients with mutations in the COL2A1 gene underwent ultra-widefield FAF imaging. The eyes were categorized into three types; no signs of abnormal AF, predominantly hyperfluorescent AF (hyper-AF), and predominantly hypofluorescent AF (hypo-AF). Goldmann perimetry was performed on 34 eyes, and line-scan images of the abnormal AF lesions were obtained by swept-source optical coherence tomography in 4 eyes. RESULTS: Abnormal AF lesions were found in 37 eyes of 21 (80.7%) of the 26 patients. Hyper-AF was found in 15 eyes and hypo-AF was found in 22 eyes. The FAF changes corresponded with the funduscopically observed radial paravascular retinal degeneration. The average age at the examination was significantly younger in patients who had eyes with hyper-AF or no abnormal AF than in those with hypo-AF (12.8 vs. 28.4 years; P = 0.009). Abnormal AF-associated visual field defects were found in 5/10 (50%) eyes with hyper-AF and 17/18 (94%) eyes with hypo-AF. Hyper-AF changes tended to appear before retinal changes were detectable by fluorescein angiography. An absence of the ellipsoid zone and the outer nuclear layer and a thinning of the overall retinal thickness were found corresponding to the hypo-AF lesions in the swept source optical coherence tomography images. CONCLUSION: Abnormal FAF is characteristic of eyes with Stickler syndrome. Age-related alterations of the FAF was associated with visual field defects and disruption of the photoreceptors and retinal pigment epithelial cells.
  • Eguchi H, Nishida K, Hotta F, Shimomura Y, Kusaka S.
    J Ocul Pharmacol Ther Mary Ann Liebert Inc 37 (2) 84 - 89 1080-7683 2021/01 
    Purpose: To determine the in vitro antimicrobial activity of quinolones against major bacterial isolates from the ocular surface bacterial flora of patients in a tertiary hospital for selection of optimal antibiotic eye drop during the perioperative stage. Methods: The conjunctival sac scraping of 933 patients who underwent ophthalmic surgery was cultivated and bacterial species of the isolates were identified. The minimum inhibitory concentrations (MICs) of gatifloxacin (GFLX), moxifloxacin (MFLX), levofloxacin (LVFX), and tosufloxacin (TFLX) were measured by microdilution methods. The cumulative percentages of MICs of 4 quinolones against major bacteria were calculated. The concentrations of quinolones inhibiting 50% (MIC50) and 90% (MIC90) of the major bacteria were compared. Results: The study mainly included 784 patients scheduled for cataract surgery, 73 for vitrectomy, 30 for corneal transplantation, 30 for conjunctival surgery, 11 for eyelid surgery. The most frequently isolated bacterium was coagulase-negative Staphylococci (CNS) (184 strains), followed by Corynebacterium (107 strains), Staphylococcus aureus (33 strains), Streptococcus (18 strains), and Enterococcus (13 strains). The percentages of methicillin-sensitive CNS isolates for which MIC of GFLX, MFLX, LVFX, and TFLX was 0.06 μg/mL or less were 8.0%, 13.4%, 5.4%, and 63.4%, respectively. Similarly, the percentage for Corynebacterium was 23.0%, 23.0%, 0%, and 35.6%, respectively. MIC50 of TFLX for Streptococcus and Enterococcus showed the lowest values, 0.12 and 0.25 μg/mL, respectively. Conclusions: Among 4 quinolones, TFLX has the highest in vitro antimicrobial activity against major bacterial isolates from the ocular surface bacterial flora of patients in a tertiary hospital.
  • Wakayama A, Nomoto H, Chiba Y, Matsumoto C, Kusaka S.
    J Glaucoma. Ovid Technologies (Wolters Kluwer Health) 30 (1) 37 - 43 1057-0829 2021/01 
    PRCIS: A difference between monocular sensitivities measured with and without occlusion was observed in glaucoma. Monocular sensitivity without occlusion could have been affected differently by binocular interaction due to the sensitivity disparity between both eyes. PURPOSE: To investigate the influence of sensitivity disparity between both eyes on visual field results under binocular viewing in glaucoma. MATERIALS AND METHODS: Thirteen glaucoma patients tested by Humphrey Field Analyzer (HFA) and imo were reviewed retrospectively. On the basis of their HFA results, we defined the eye with a better HFA-MD as "the better eye" and the fellow eye with a worse HFA-MD as "the worse eye." Depending on the pointwise pattern deviation (PD) of both eyes, all evaluated test points were classified into 4 groups: normal PD in both eyes (N/N), normal PD in the better eye but abnormal in the worse eye (N/A), abnormal PD in the better eye but normal in the worse eye (A/N), and abnormal PD in both eyes (A/A). Using imo, which can measure sensitivity with and without occluding the nontested eye, the better eye's sensitivities with and without occlusion were compared in each group using weighted data. The weight was derived by applying the inverse probability weighting. RESULTS: Monocular sensitivity without occlusion was higher than that with occlusion in N/N (P<0.01) and the opposite was observed in A/A (P<0.05). No significant sensitivity difference between both conditions was seen in N/A or A/N. In N/A, the points showing a higher sensitivity without occlusion decreased as the sensitivity difference between both eyes increased. CONCLUSIONS: A difference between sensitivities measured with and without occlusion was observed in glaucoma. Owing to the sensitivity disparity between both eyes, monocular sensitivity without occlusion could have been affected differently by binocular interaction.
  • Sakamoto M, Kuniyoshi K, Hayashi S, Yamashita H, Kusaka S.
    Am J Ophthalmol Case Rep. Elsevier BV 20 100964  2451-9936 2020/12
  • Aomatsu K, Kusaka S.
    Case Rep Ophthalmol Med. Hindawi Limited 2090-6722 2020/11 
    Purpose. To report a case of isolated superior oblique muscle swelling causing acute vertical strabismus in Graves’ disease. Case. A 26-year-old woman with a 1-month history of misalignment of the right eye and diplopia was referred to us. Her visual acuity and intraocular pressures were normal in both eyes, but eye movement tests showed clear misalignment of her right eye. Antibody tests for myasthenia gravis were negative. However, blood tests revealed abnormal levels of thyroid-related factors, such as decreased thyroid-stimulating hormone, elevated free T3 and T4, and elevated anti-thyroid-stimulating hormone receptor antibody. We performed magnetic resonance imaging (MRI), which showed slight enlargement of the left superior oblique muscle. The patient was eventually diagnosed with Graves’ disease with superior oblique muscle involvement and underwent a thyroidectomy. Three months postoperatively, her diplopia and abnormal eye movements had substantially resolved. Conclusion. Isolated superior oblique muscle involvement may be a presenting symptom of Graves’ disease. It should be taken into consideration that, in the early stages of thyroid-associated ophthalmopathy (TAO) in adults, only the superior oblique muscle may be enlarged.
  • Hotta F, Eguchi H, Nakayama-Imaohji H, Kuwahara T, Tada A, Yagi H, Shimomura Y, Kusaka S.
    Int J Mol Med. Spandidos Publications 46 (4) 1367 - 1376 1107-3756 2020/10
  • Eguchi H, Hotta F, Kusaka S, Shimomura Y.
    J Ophthalmol. Hindawi Limited 1497089  2090-004X 2020/09 
    Intraoperative optical coherence tomography (iOCT) is widely used in ophthalmic surgeries for cross-sectional imaging of ocular tissues. The greatest advantage of iOCT is its adjunct diagnostic efficacy, which facilitates to decision-making during surgery. Since the development of microscopic-integrated iOCT (MIOCT), it has been widely used mainly for vitreoretinal and anterior segment surgeries. In corneal transplantation, MIOCT allows surgeons to visualise structure underneath the turbid and distorted cornea, which are impossible to visualise with a usual microscope. Real-time visualisation of hard-to-see area reduces the operation time and leads to favorable surgical outcomes. The use of MIOCT is advantageous for a variety of corneal surgical procedures. Here, we have reviewed articles focusing on the utility of iOCT  and MIOCT in penetrating keratoplasty, deep anterior lamellar keratoplasty, Descemet stripping automated endothelial keratoplasty, and Descemet membrane endothelial keratoplasty. The applications of MIOCT to corneal surgery in terms of surgical education for trainees, emergency surgery, and novel surgery are also discussed, with our cases performed using RESCAN® 700.
  • Huang YP, Vadloori S, Chu HC, Kang EY, Wu WC, Kusaka S, Fukushima Y.
    Electronics MDPI AG 9 (9) 1444  2020/09 [Refereed]
     
    Retinopathy of prematurity (ROP) is a disease that can cause blindness in premature infants. It is characterized by immature vascular growth of the retinal blood vessels. However, early detection and treatment of ROP can significantly improve the visual acuity of high-risk patients. Thus, early diagnosis of ROP is crucial in preventing visual impairment. However, several patients refrain from treatment owing to the lack of medical expertise in diagnosing the disease; this is especially problematic considering that the number of ROP cases is on the rise. To this end, we applied transfer learning to five deep neural network architectures for identifying ROP in preterm infants. Our results showed that the VGG19 model outperformed the other models in determining whether a preterm infant has ROP, with 96% accuracy, 96.6% sensitivity, and 95.2% specificity. We also classified the severity of the disease; the VGG19 model showed 98.82% accuracy in predicting the severity of the disease with a sensitivity and specificity of 100% and 98.41%, respectively. We performed 5-fold cross-validation on the datasets to validate the reliability of the VGG19 model and found that the VGG19 model exhibited high accuracy in predicting ROP. These findings could help promote the development of computer-aided diagnosis.
  • Yamada K, Maeno T, Kusaka S, Arroyo JG, Yamada M.
    Clin Ophthalmol. Dove Medical Press 14 2301 - 2306 2020/08 [Refereed]
  • Iwahashi C, Eguchi H, Hotta F, Uezumi M, Sawa M, Kimura M, Yaguchi T, Kusaka S.
    BMC Infect Dis Springer Science and Business Media LLC 20 (1) 2020/08 [Refereed]
  • Aomatsu K, Sugioka K, Kodama-Takahashi A, Fukuda M, Mishima H, Kusaka S.
    Case Rep Oncol Med. Hindawi Limited 2020 2090-6706 2020/07 
    Purpose. To report a case of corneal perforation, in a patient with a history of herpetic keratitis, during combination chemotherapy including cetuximab. Case. We report the case of a 71-year-old man who was diagnosed with a hypopharyngeal carcinoma and received radiation therapy combined with cetuximab, the epidermal growth factor receptor (EGFR) inhibitor monoclonal antibody. He was referred to us because of ocular hyperemia and corneal perforation in his left eye. In spite of conservative therapy, his corneal perforation was exacerbated, with iris incarceration into the wound site and exposure to the surface of the cornea. He therefore discontinued treatment with the combination chemotherapy and underwent lamellar keratoplasty using a preserved donor cornea. After treatment with cetuximab resumed, there was no recurrence of the corneal perforation. Conclusion. We have presented the first case of cetuximab-related corneal perforation in a patient who had a history of recurrent herpetic keratitis. EGFR inhibitors, such as cetuximab, can induce corneal perforation in cases with a history of herpetic stromal keratitis.
  • Yamao S, Kusaka S.
    JAMA Ophthalmol 138 (5) e191452  2020/05 [Refereed]
  • Katagiri S, Hayashi T, Nakamura M, Mizobuchi K, Gekka T, Komori S, Ueno S, Terasaki H, Sakuramoto H, Kuniyoshi K, Kusaka S, Nagashima R, Kondo M, Fujinami K, Tsunoda K, Matsuura T, Kondo H, Yoshitake K, Iwata T, Nakano T.
    Invest Ophthalmol Vis Sci. Association for Research in Vision and Ophthalmology (ARVO) 61 (3) 1552-5783 2020/03
  • Kuniyoshi K, Hayashi T, Kameya S, Katagiri S, Mizobuchi K, Tachibana T, Kubota D, Sakuramoto H, Tsunoda K, Fujinami K, Yoshitake K, Iwata T, Nakano T, Kusaka S.
    Int J Mol Sci. MDPI AG 21 (4) 2020/02 
    DRAM2-associated retinopathy is a rare inherited retinal dystrophy, and its outcome has not been determined. A single retinal involvement by a mutation of the DRAM2 gene is unexplained. We found three unrelated patients with a disease-causing DRAM2 variant in a biallelic state from 1555 Japanese individuals of 1314 families with inherited retinal dystrophy. We reviewed their medical records and examined their peripheral lymphocytes by transmission electron microscopy (TEM). Patient 1 was a 38-year-old woman who complained of night blindness and reduced vision. She developed macular degeneration at age 43 years. Patients 2 and 3 were a man and a woman both of whom noticed night blindness in their 30s. Both had a degeneration in the macula and midperiphery in their 40s, which progressed to a diffuse retinal degeneration in their 60s when their vision was reduced to hand motions. Three novel DRAM2 variants were identified. TEM of the lymphocytes of Patients 1 and 2 showed abnormal structures in 40.6% and 0.3% of the peripheral lymphocytes, respectively. We concluded that the DRAM2-associated retinopathy of our patients was a progressive rod-cone dystrophy, and the visual outcome was poor. The systemic effect of DRAM2 mutations may be compensable and have variations.
  • Nishida K, Sugioka K, Murakami J, Kodama-Takahashi A, Nanri I, Mishima H, Nishida T, Kusaka S.
    Exp Eye Res. Elsevier BV 191 0014-4835 2020/02
  • Enomoto A, Fukuda M, Matsunaga K, Kusaka S, Shimomura Y, Hamada S.
    Br J Oral Maxillofac Surg. 57 (9) 861 - 865 2019/11 [Refereed]
     
    Osteo-odontokeratoprosthesis (OOKP) is a technique invented by Strampelli in 1963, in which the patient's own tooth root is used to support an optical cylinder. It uses an autologous tooth-bone-periodontal complex to mount an optical cylinder, which is stabilised by overlying autologous buccal mucosa. OOKP involves two, staged procedures done by ophthalmologists and oral surgeons, and the main contribution from the oral surgeon is during the first stage. To date we have done nine first-stage, and completed eight second-stage, OOKP operations in Japan with a mean follow-up of eight years and 11 months by modifying the original method of the oral surgery. All OOKP procedures were unilateral, and canines were selected as the donor teeth. Patients developed ocular blindness as a result of Stevens-Johnson syndrome, ocular cicatricial pemphigoid, and chemical and thermal burns to the cornea and ocular surface. All eight patients who completed the second stage have been stable, and there have been no major perioperative or postoperative oral complications. The patients' visual acuities were stable with no serious complications. Here we report the technical details of the oral contribution to OOKP.
  • Sato T, Sugioka K, Kodama-Takahashi A, Murakami J, Saito A, Mishima H, Nishida T, Kusaka S.
    Invest Ophthalmol Vis Sci. Association for Research in Vision and Ophthalmology (ARVO) 60 (13) 4205 - 4214 0146-0404 2019/10 [Refereed]
  • Iwata A, Kusaka S, Ishimaru M, Kondo H, Kuniyoshi K.
    Am J Ophthalmol Case Rep. Elsevier BV 15 100493 - 100493 2451-9936 2019/09 [Refereed]
  • Sugioka K, Yoshida K, Murakami J, Itahashi M, Mishima H, Nishida T, Kusaka S.
    Invest Ophthalmol Vis Sci. Association for Research and Vision and Ophthalmology 60 (8) 2895 - 2903 0146-0404 2019/07 [Refereed]
     
    PURPOSE: The proinflammatory cytokine interleukin (IL)-1 is implicated in corneal ulceration and promotes collagen degradation by corneal fibroblasts cultured in a three-dimensional (3D) collagen gel. Epigallocatechin-3-gallate (EGCG), the principal polyphenol in extracts of green tea, has various beneficial health effects, some of which appear to be mediated through direct or indirect inhibition of protease activity. We therefore examined the effect of EGCG on IL-1β-induced collagen degradation by corneal fibroblasts embedded in a collagen gel. METHODS: Human corneal fibroblasts were cultured in a type I collagen gel. Collagen degradation was assessed by measurement of hydroxyproline in acid hydrolysates of culture supernatants. The expression of urokinase-type plasminogen activator (uPA) was examined by real-time and RT-PCR analysis and by fibrin zymography, and that of the collagenase matrix metalloproteinase 1 (MMP1) was detected by immunoblot analysis. RESULTS: EGCG inhibited IL-1β-induced, plasminogen-dependent collagen degradation by corneal fibroblasts in a concentration-dependent manner. It also attenuated the IL-1β-induced expression of uPA at both mRNA and protein levels. EGCG inhibited the IL-1β-induced conversion of exogenous plasminogen to plasmin as well as the plasminogen-dependent activation of pro-MMP1 in the 3D cultures without a substantial effect on pro-MMP1 abundance. CONCLUSIONS: EGCG inhibits IL-1β-induced collagen degradation by corneal fibroblasts, with this effect likely being mediated by suppression of the upregulation of uPA, the uPA-mediated conversion of plasminogen to plasmin, and the plasmin-mediated activation of pro-MMP1. EGCG thus warrants further investigation as a potential treatment for corneal ulcer.
  • Ueno S, Eguchi H, Hotta F, Fukuda M, Kimura M, Yagita K, Suzuki T, Kusaka S.
    Ann Clin Microbiol Antimicrob. BMC Part of Springer Nature 18 (1) 2019/06 [Refereed]
  • Ishibashi M, Matsumoto C, Hashimoto S, Eura M, Okuyama S, Nomoto H, Tanabe F, Kayazawa T, Numata T, Kusaka S.
    Br J Ophthalmol. BMJ Journals 103 (11) 1672 - 1676 0007-1161 2019/01 [Refereed]
     
    BACKGROUND/AIMS: Car accidents caused by drivers unaware of their visual field (VF) defects under binocular vision have become an issue. We developed a simple self-check chart (CLOCK CHART binocular edition (CCBE)) to help patients with glaucoma recognise their abnormalities in the binocular VF and evaluated its usefulness. METHODS: The chart has four targets displayed at 10°, 15°, 20° and 25° eccentricities. The examinee gradually rotates the chart 360° clockwise. At every 30°, the examinee confirms the fixation and indicates if all four targets can be seen. This study enrolled 88 eyes of 44 patients with glaucoma (mean age, 64.4±13.1 years) and 64 eyes of 32 visually normal individuals (mean age, 32.0±8.4 years). Except the CCBE test, static VF testing using the Humphrey field analyser (HFA) Swedish Interactive Threshold Algorithm-Standard 30-2 and binocular Esterman programmes was also performed for the subjects with glaucoma. RESULTS: VF abnormality was defined as two or more contiguous points with a sensitivity of <10 dB within the central 30°. The CCBE test had sensitivities of 85% and 82% with respect to the HFA and Esterman results, respectively. We also used the British VF standards for Group 1 (car/motorcycle) drivers, and a sensitivity of 88% was obtained for the CCBE. The chart had a specificity of 100% for the visually normal subjects. CONCLUSION: The CCBE test enables drivers with glaucoma to notice their VF abnormalities under binocular condition. The application of this simple self-check method appears promising for occasions such as driver licensing.
  • Kondo H, Oku K, Katagiri S, Hayashi T, Nakano T, Iwata A, Kuniyoshi K, Kusaka S, Hiyoshi A, Uchio E, Kondo M, Oishi N, Kameya S, Mizota A, Naoi N, Ueno S, Terasaki H, Morimoto T, Iwaki M, Yoshitake K, Iejima D, Fujinami K, Tsunoda K, Shinoda K, Iwata T.
    Hum Genome Var. Springer Nature 6 2019/01 [Refereed]
     
    X-linked congenital retinoschisis (XLRS) is an inherited retinal disorder characterized by reduced central vision and schisis of the macula and peripheral retina. XLRS is caused by mutations in the RS1 gene. We have identified 37 different mutations in the RS1 gene, including 12 novel mutations, in 67 Japanese patients from 56 XLRS families. We present clinical features of these patients in relation to the associated mutations.
  • Surgical Management of Severe Retinopathy of Prematurity
    Kusaka S.
    Acta Med Kindai Univ 近畿大学医学会 43 (2) 51 - 56 2018/12
  • Sugioka K, Kodama-Takahshi A, Sato T, Okada K, Murakami J, Park AM, Mishima H, Shimomura Y, Kusaka S, Nishida T.
    Investigative Opthalmology & Visual Science Association for Research in Vision and Ophthalmology (ARVO) 59 (12) 5098 - 5098 1552-5783 2018/10
  • Sugioka K, Kodama-Takahshi A, Sato T, Okada K, Murakami J, Park AM, Mishima H, Shimomura Y, Kusaka S, Nishida T.
    Invest Ophthalmol Vis Sci. 59 (12) 5098 - 5107 0146-0404 2018/10 [Refereed]
     
    Purpose: Staphylococcus aureus is a common cause of corneal ulceration, and staphylokinase (SAK) produced by this bacterium is a plasminogen activator. To investigate the pathogenesis of corneal ulceration induced by S. aureus, we examined the effects of bacterial culture broth and SAK on collagen degradation in a culture model in which human corneal fibroblasts are embedded in a collagen gel. Methods: Corneal fibroblasts embedded in collagen were exposed to S. aureus culture broth or SAK. Collagen degradation was assessed by measurement of hydroxyproline in acid hydrolysates of culture supernatants. Expression of pro-matrix metalloproteinase-1 (pro-MMP-1) was detected by immunoblot analysis as well as reverse transcription and real-time polymerase chain reaction analysis. Results: Both S. aureus culture broth and SAK markedly increased collagen degradation in the presence of corneal fibroblasts and plasminogen. This effect of the culture broth was dependent on cell number to a greater extent than was that of SAK. Whereas the culture broth also increased the expression of pro-MMP-1 in corneal fibroblasts at both mRNA and protein levels, SAK did not. Conclusions: Our results suggest that S. aureus may promote collagen degradation both by upregulating pro-MMP1 expression in corneal fibroblasts, with pro-MMP-1 then being converted to active MMP-1 by plasmin, and by directing plasmin activity toward collagen in a SAK-dependent manner.
  • Fukushima Y, Fujino T, Kusaka S, Hatsukawa Y, Nishida K.
    Am J Ophthalmol Case Rep. 11 66 - 71 2018/09 [Refereed]
     
    Purpose: To evaluate the effect of salvage therapy with bevacizumab after laser photocoagulation for infants with recurrence of zone I aggressive-posterior retinopathy of prematurity (AP-ROP). Methods: This was a retrospective case series documenting the 2-year outcomes of 8 patients diagnosed with zone I AP-ROP and treated with bevacizumab for recurrence after laser photocoagulation. Prior to intravitreal bevacizumab, additional laser treatment was performed when any skip areas on the avascular retina remained. Anatomical and functional outcomes were evaluated. Results: The median gestational age at birth was 23.7 weeks and the median birth weight was 541.5 g. The median time of initial laser treatment and intravitreal bevacizumab treatment were 32.1 weeks and 36.7 weeks' postmenstrual age, respectively. All 14 eyes developed a normal macular appearance and all 8 patients had visual responses. Visual acuity was measurable in 13 eyes (92%) between the chronological ages of 12-24 months. Conclusions: and Importance: Adequate laser treatment and salvage intravitreal bevacizumab achieved favorable anatomical and functional outcomes in AP-ROP patients with recurrence.
  • Tanaka M, Matsumoto F, Kusaka S.
    Case Rep Ophthalmol S. Karger AG 9 (2) 304 - 309 2018/05 
    Binocular vision may be compromised in children after unilateral cataract surgery because the distances at which clear vision is present are different for the two eyes. We believe that wearing progressive additional lenses can be effective in improving the binocular vision in children with pseudophakia.
  • Kondo H, Uchio E, Kusaka S, Higasa K.
    Ophthalmic Genet. Informa UK Limited 39 (3) 405 - 406 1381-6810 2018/05
  • Kusaka S.
    Asia Pac J Ophthalmol. (Phila) Asia Pacific Academy of Ophthalmology 7 (3) 156 - 159 2162-0989 2018/05
  • Kusaka S.
    Retinal Detachment Surgery and Proliferative Vitreoretinopathy Springer International Publishing 269 - 273 2018/04
  • Nakamoto Y, Takada R, Tanaka M, Matsumoto F, Aomatsu K, Tachibana K, Eguchi H, Kusaka S.
    Ophthalmic Res. S. Karger AG 60 (4) 231 - 237 0030-3747 2018
  • Kusaka S.
    Taiwan J Ophthalmol . Medknow 8 (4) 216 - 221 2211-5056 2018
  • 高田 遼太, 松本 富美子, 若山 曉美, 百海 紗弥香, 関 ゆかり, 高橋 里佳, 梅原 郁美, 田中 玲湖, 児島 理恵, 歌村 圭介, 阿部 考助, 七部 史, 日下 俊次, 三島 弘, 石場 義久, 下村 嘉一.
    日本視能訓練士協会誌 JAPANESE ASSOCIATION OF CERTIFIED ORTHOPTISTS 46 257 - 262 0387-5172 2017/12 [Refereed]
     

    [Purpose] To evaluate the usefulness of a newly developed red filter ladder ( "the Yamamoto's filters" ; Yamamoto Kogaku Co., Ltd., Osaka, Japan) in measuring phoria maintenance ability, we used the Yamamoto's filters and the existing Bagolini's red filter bar ( "the SBISA's filters" ; SBISA INDUSTRIALE SPA, Firenze, Italy) to assess patients' abilities to maintain phoria and compared the performance of the two series of filters.

    [Subjects and Methods] Inclusion criteria for subjects were: age 3 to 15 years, best corrected visual acuity of ≤ 1.0 in both eyes, diagnosed as intermittent exotropia [X(T)], and maintained phoria at near (30 cm) and far (5 m) distances. Exclusion criteria were dissociated vertical deviation, unable to respond to subjective examinations, and ocular diseases except X(T). We enrolled 31 subjects (14 boys and 17 girls) aged from 5 to 15 years (mean ± standard deviation, 10.5 ± 2.7 years). With refraction correction, the subject was instructed to fixate on a small light source and a red filter ladder was placed in front of the non-dominant eye. Starting with filter No. 1 with the highest luminous transmittance rate, the filter strength was increased up to filter No. 17 with the lowest luminous transmittance rate. As the load on the eye was increased, the red filter number immediately before the eye changed to tropia was determined as the patient's phoria maintenance ability. The tests by the Yamamoto's and SBISA's filters were performed in a random order and a 10-minute recess was given. The performance of both filter series was compared using the luminous transmittance rate as an indicator of the phoria maintenance ability.

    [Results] Within the range where the two series of filters had the same luminous transmittance rate, no significant difference in the measured phoria maintenance ability was observed between the Yamamoto's and SBISA's filters (Wilcoxon signed-rank test, Near, p = 0.14; Far, p = 0.37).

    [Conclusion] The Yamamoto's red filter ladder is as useful as the SBISA's filters in quantifying phoria maintenance ability.

  • Eguchi H, Hotta F, Kuwahara T, Imaohji H, Kusaka S, Shimomura Y.
    Medicine (United States) Lippincott Williams and Wilkins 96 (50) e9310  1536-5964 2017/12 [Refereed]
     
    Rationale:Contact lens storage cases are known to be contaminated by a significant number of bacteria. However, histamine-producing Raoultella species has not been reported to contaminate contact lens storage case.Patient concerns:A 27-year-old woman with keratoconjunctivitis that developed in the left eye owing to a cosmetic contact lens and poor hygiene was referred to our hospital. The corrected visual acuity was hand motion.Diagnoses:Corneal infection other than Acanthamoeba keratitis (AK) and corneal hypoxia were excluded.Interventions:We initiated empirical therapy for AK, although no cysts or trophozoites were detected in the cornea and in the lens care solution. Analysis of 16S rDNA sequences from the lens care solution yielded the highest homology with Raoultella species, which are histamine-producing bacteria. Histamine was estimated to be 492 ng/mL in the lens care solution.Outcomes:Her clinical course was distinct from that of usual AK cases. The corrected visual acuity increased up to (1.2) only 5 days after initiating empirical therapy.Lessons:To our knowledge, this is the first report to indicate an association between histamine-producing bacteria and keratoconjunctivitis. We should pay an attention to the microbial contamination of contact lens storage cases by histamine producing bacteria.
  • Eguchi H, Hiura A, Nakagawa H, Kusaka S, Shimomura Y.
    Biomed Res Int. HINDAWI LTD 2017 2314-6133 2017/11 [Refereed]
     
    Recently, in vivo confocal microscopy is used to examine the human corneal nerve fibers morphology. Corneal nerve fiber architecture and its role are studied in healthy and pathological conditions. Corneal nerves of rats were studied by nonspecific acetylcholinesterase (NsAchE) staining. NsAchE-positive subepithelial (stromal) nerve fiber has been found to be insensitive to capsaicin. Besides, NsAchE-negative but capsaicin-sensitive subbasal nerve (leash) fibers formed thickmesh-like structure showing close interconnections and exhibit both isolectin B4-and transient receptor potential vanilloid channel 1-(TRPV1-) positive. TRPV1, TRPV3, TRPA (ankyrin) 1, and TRPM (melastatin) 8 are expressed in corneal nerve fibers. Besides the corneal nerve fibers, the expressions of TRPV (1, 3, and 4), TRPC (canonical) 4, and TRPM8 are demonstrated in the corneal epithelial cell membrane. The realization of the importance of TRP channels acting as polymodal sensors of environmental stresses has identified potential drug targets for corneal disease. The pathophysiological conditions of corneal diseases are associated with disruption of normal tissue innervation, especially capsaicin-sensitive small sensory nerve fibers. The relationships between subbasal corneal nerve fiber morphology and neurotrophic keratopathy in corneal diseases are well studied. The recommended treatment for neurotrophic keratopathy is administration of preservative free eye drops.
  • Kusaka S, Tachibana K, Tsujioka D, Hotta F, Eguchi H, Shimomura Y.
    Retina Ovid Technologies (Wolters Kluwer Health) 37 (11) e143 - e144 0275-004X 2017/11
  • Eguchi H, Hotta F, Kuwahara T, Imaohji H, Miyazaki C, Hirose M, Kusaka S, Fukuda M, Shimomura Y.
    Cornea Lippincott Williams and Wilkins 36 S46 - S52 1536-4798 2017/11 [Refereed]
     
    Ocular infection is caused by both endogenous (resident) and exogenous (environmental) microbes. As the ocular surface interacts with both outer environment and its own resident microbiota, clinical ocular samples are predicted to contain a diverse set of microorganisms. Microscopy of sample smears is an important step in the diagnostic process of infectious diseases to interpret the culture results. Traditional culture techniques have several limitations in the detection and/or identification of uncharacterized bacteria of environmental origin. Molecular biological techniques, such as polymerase chain reaction of pathogen-specific virulence genes, 16S rRNA gene clone library analysis, and nextgeneration sequencing of 16S rDNA amplicons, compensate for diagnostic culture techniques in diagnosing infectious diseases. These techniques are expected to provide novel insights into the ocular microbiota and pathology of ocular infections. In this article, we describe various ocular infections, including contact lens- related keratitis, silicone buckle infection, and dacryocystitis, which were analyzed using molecular biological techniques. The advantages and disadvantages of these highly sensitive and inclusive microbiological detection systems for ocular infections are discussed.
  • 〔外国誌要覧〕MRワクチン後の幼児に発症した急性の視細胞変性.
    國吉 一樹, 初川 嘉一, 木村 貞美, 藤野 貴啓, 大黒 浩, 中井 理恵, 角南 健太, 三島 壮一郎, 佐藤 朋子, 日下 俊次, 鈴木 保宏, 下村 嘉一.
    日本眼科学会雑誌 公益財団法人日本眼科学会 121 (10) 782 - 783 2017/10 [Refereed]
  • Sugioka K, Saito S, Kusaka S, Kuniyoshi K, Shimomura Y.
    Biochem Biophys Res Commun. ACADEMIC PRESS INC ELSEVIER SCIENCE 488 (3) 483 - 488 0006-291X 2017/07 [Refereed]
     
    Retinopathy of prematurity (ROP) is a disorder of blood vessels in the retina developed in premature infants and the leading cause of the blindness in children. Proteomic analysis was performed to identify vitreous proteins specific to patients with ROP. Vitreous humor samples were obtained from three patients with ROP and two patients with congenital cataract, the latter included as a control group. The vitreous samples were separated by 2D-PAGE and the proteins running as definitive spots were identified by MALDI-TOF MS spectrometry. We identified 13 and 6 proteins in the vitreous from ROP and cataract patients, respectively. Albumin, transferrin, pigment epithelium-derived factor (PEDF) and transthyretin were found in both patient groups. In the samples from ROP patients, PEDF and transthyretin levels were lower than in those from cataract patients, and retinol binding protein 3 and prostaglandin D synthase were not detected. Of the 13 proteins, 9 proteins including alpha-2-macroglobulin, ceruloplasmin, a-fetoprotein, vitamin D-binding protein, a-l-antitrypsin, alpha-1-beta-glycoprotein, hemopexin, apolipoprotein A-1 and A-1V were found in vitreous samples of only the ROP patients. PEDF has anti-angiogenic and neurotrophic functions. Whether PEDF is increased or decreased in diabetic retinopathy has been controversial but we observed lower PEDF in the ROP samples than in the controls. The proteins specific to or decreased in ROP, if confirmed in future studies, may provide clue to understanding its pathogenesis. (C) 2017 Elsevier Inc. All rights reserved.
  • Vitrectomy for Retinopathy of Prematurity.
    Sugioka K, Saito A, Kusaka S, Kuniyoshi K, Shimomura Y.
    Turkiye Klinikleri J Ophthalmol. 10 (2) 134 - 138 2017/06 [Refereed]
  • Matsushita I, Nagata T, Hayashi T, Kimoto K, Kubota T, Ohji M, Kusaka S, Kondo H.
    Ophthalmology. ELSEVIER SCIENCE INC 124 (6) 896 - 902 0161-6420 2017/06 [Refereed]
     
    Purpose: To determine the microstructure of the fovea in patients with Stickler syndrome using imaging by spectral-domain optical coherence tomography (SD OCT) and swept-source OCT. Design: Retrospective case series study. Participants: A total of 39 eyes of 25 patients with genetically confirmed Stickler syndrome were studied. Methods: All of the patients had mutations in the COL2A1 gene and were diagnosed with Stickler syndrome. Cross-sectional OCT images, OCT angiography (OCTA), and en face OCT images were assessed. The ratio of the foveal inner retinal layer (fIRL) thickness to the parafoveal inner retinal layer (pIRL) thickness, the ratio of the foveal outer retinal layer (fORL) thickness to the parafoveal outer retinal layer (pORL) thickness, and the size of the foveal avascular zone (FAZ) were determined. Main Outcome Measures: The degree of foveal hypoplasia and the best-corrected visual acuity in patients with Stickler syndrome. Results: A persistence of the inner retinal layers in the fovea with an fIRL/pIRL ratio >0.2 was present in 32 of the 39 eyes (82%). Optical coherence tomography angiography showed that the FAZ was smaller, 0 to 0.19 mm(2), than that of normal eyes, in 25 eyes of 17 patients who underwent OCTA. There was no significant correlation between the visual acuities and the fIRL/pIRL ratios. Conclusions: A mild foveal hypoplasia with a persistence of the IRL is characteristic of eyes with Stickler syndrome. The visual acuities were not correlated with the fIRL/pIRL ratios. (C) 2017 by the American Academy of Ophthalmology
  • Eguchi H, Kusaka S, Arimura-Koike E, Tachibana K, Tsujioka D, Fukuda M, Shimomura Y.
    Int Ophthalmol . Springer Science and Business Media LLC 37 (3) 761 - 765 0165-5701 2017/06 [Refereed]
     
    There is no report focusing on the visualization of the iris incarceration or the iridocorneal adhesion during keratoplasty by use of microscope-integrated intraoperative optical coherence tomography (MIOCT). The purpose of this study is to report the usefulness of MIOCT for detecting iris incarceration and iridocorneal adhesions during penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK). MIOCT system was applied both in a patient who underwent PK for corneal leukoma and in a patient who underwent DALK for keratoconus. During the surgeries, we obtained cross-sectional images around the host-graft interface by operating the foot switch of microscope without discontinuing the surgical procedure. Intraoperative MIOCT findings and postoperative outcomes were examined. An iris incarceration at the host-graft interface was visualized during surgery after corneal suture in PK, which allowed surgeons to return the iris to its original position instantly. In DALK, misdirected air into the posterior chamber could also be seen at the end of the DALK. This iridocorneal adhesion was resolved by fluid injection through paracentesis. Secondary glaucoma and graft rejection have not occurred postoperatively in both cases. The MIOCT system provides advantages such as prevention of secondary glaucoma and rejection following PK and DALK.
  • Kusaka S, Tachibana K, Tsujioka D, Hotta F, Eguchi H, Shimomura Y.
    Retina. LIPPINCOTT WILLIAMS & WILKINS 37 (6) 1215 - 1217 0275-004X 2017/06 [Refereed]
  • Todorich B; Thanos A; Yonekawa Y; Thomas BJ; Faia LJ; Chang E; Shulman J; Olsen KR; Blair MP; Shapiro MP; Ferrone P; Vajzovic L; Toth CA; Lee TC; Robinson J; Hubbard B; Kondo H; Besirli CG; Nudleman E; Wong SC; Kusaka S; Walsh M; Chan RVP; Berrocal A; Caputo G; Murray TG; Sears J; Schunemann R; Harper CA; rd; Kychental A; Dorta P; Cernichiaro-Espinosa LA; Wu WC; Campbell JP; Martinez-Castellanos MA; Quiroz-Mercado H; Hayashi H; Quiram P,Amphornphruet A; Hartnett ME; Tsui I; Ells A; John V; Moshfeghi D; Capone A Jr; Drenser KA; Trese MT
    Retina (Philadelphia, Pa.) 37 (5) e52 - e54 0275-004X 2017/05 [Refereed]
  • Kuniyoshi K, Hatsukawa Y, Kimura S, Fujino T, Ohguro H, Nakai R, Sunami K, Mishima SI, Sato T, Kusaka S, Suzuki Y, Shimomura Y.
    JAMA Ophthalmol. AMER MEDICAL ASSOC 135 (5) 478 - 482 2168-6165 2017/05 [Refereed]
     
    IMPORTANCE Ocular inflammation is occasionally observed after vaccinations, and most of them resolve without permanent visual disturbances. However, there are some rare cases of severe ocular complications following vaccinations. OBJECTIVE To report the findings in an infant boy who developed an acute loss of vision bilaterally after Haemophilus influenzae type b, Pneumococcal conjugate vaccination, and measles and rubella vaccination. His vision did not recover. DESIGN, SETTING, AND PARTICIPANT A retrospective review of the medical records of a 13-month-old Japanese boy. MAIN OUTCOMES AND MEASURES Fundus and fluorescein angiographic findings, ultrasonographic and optical coherence tomographic images, and electroretinographic findings. RESULTS A healthy 13-month-old boy had an acute loss of vision in both eyes 31 days after Haemophilus influenzae type b and Pneumococcal conjugate vaccinations and 24 days after a measles and rubella vaccination. He also developed a common cold 10 days before the vision loss. Ultrasonography showed an exudative retinal detachment 1 day after the onset of the visual reduction; however, his fundi appeared normal 4 days later. His eyes did not pursue objects, and pupillary light reflexes were not present. No signs of anterior uveitis were noted. He was treated with corticosteroids, but his vision did not improve. The retinal vessels gradually attenuated, and diffuse small white punctate lesions appeared in the deep retina. Optical coherence tomography showed a thinner outer nuclear layer and an absent ellipsoid zone. The electroretinograms were nonrecordable. These findings suggested a severe impairment of the photoreceptors, especially their outer segments. Western blot analysis of the patient's sera detected an antibody against recoverin, a calcium-binding protein of photoreceptors. CONCLUSIONS AND RELEVANCE We hypothesize that an infection induced severe chorioretinitis with an exudative retinal detachment, which then produced an autoantibody against recoverin. The autoantibody then altered the function of the photoreceptors very rapidly. The initial infection may have been caused by the measles and rubella vaccination. However, because to our knowledge this has not been reported previously, the visual loss after the vaccinations may have been an extremely rare event that was coincidental or may have been related to the vaccination.
  • Hotta F, Eguchi H, Nishimura K, Kogiso M, Ishimaru M, Kusaka S, Shimomura Y, Yaguchi T.
    Ann Clin Microbiol Antimicrob. Springer Science and Business Media LLC 16 (1) Article11  1476-0711 2017/03
  • Kondo H, Matsushita I, Tahira T, Uchio E, Kusaka S.
    Ophthalmic Genet. TAYLOR & FRANCIS INC 37 (4) 462 - 464 1381-6810 2016/12 [Refereed]
  • Kuniyoshi K, Sakuramoto H, Sugioka K, Matsumoto C, Kusaka S, Shimomura Y.
    Int. Ophthalmol. SPRINGER 36 (4) 601 - 605 0165-5701 2016/08 [Refereed]
     
    To report the light- and dark-adapted perimetric findings in a patient with multiple evanescent white dot syndrome (MEWDS). The patient was a 25-year-old Japanese woman who underwent comprehensive ophthalmological examinations including measurements of the visual acuity, dilated ophthalmoscopy, Goldmann kinetic perimetry, electroretinography (ERG), indocyanine green fundus angiography (ICGA), and optical coherence tomography (OCT). Kinetic perimetry was performed under light- and dark-adapted conditions. The patient was diagnosed with MEWDS by the fundus and visual field findings, and the ICGA abnormalities. Light-adapted perimetry showed an enlargement of the blind spot; however, the size of the blind spot was normalized with dark-adaptation. Amplitude of cone ERG was more reduced than that of rod ERG in the affected eye. The OCT images showed multiple disruptions of the ellipsoid and interdigitation zones. These abnormalities were still present 9 months after the onset although the fundus appeared normal. These findings indicate a persistent cone-dominated dysfunction in a patient with MEWDS.
  • 高田 遼太, 松本 富美子, 立花 都子, 江口 洋, 日下 俊次.
    視覚の科学 日本眼光学学会 37 (2) 41 - 44 2016/08 [Refereed]
     

    The accuracies of four intraocular lens power calculation formulas, SRK/T, Haigis, Holladay I, and Hoffer Q, were ascertained for long axial length eye measurement during perioperative stages. The axial length, keratometric data, and anterior chamber depth were measured using an IOL MasterTM, and the refractive errors of each formula were compared in consecutive cases in eyes with an axial length greater than 26.0 mm. The refractive errors in the early postoperative period obtained using SRK/T, Haigis, Holladay I, and Hoffer Q were +0.32±0.58 D, +0.42±0.60 D, +0.83±0.63 D, and +0.89±0.63 D, respectively. These results suggested that the SRK/T or Haigis formulas should be used for intraocular lens power calculation in eyes with a long axial length.

  • Yonekawa Y, Wu WC, Kusaka S, Robinson J, Tsujioka D, Kang KB, Shapiro MJ, Padhi TR, Jain L, Sears JE, Kuriyan AE, Berrocal AM, Quiram PA, Gerber AE, Paul Chan RV, Jonas KE, Wong SC, Patel CK, Abbey AM, Spencer R, Blair MP, Chang EY, Papakostas TD, Vavvas DG, Sisk RA, Ferrone PJ, Henderson RH, Olsen KR, Hartnett ME, Chau FY, Mukai S, Murray TG, Thomas BJ, Meza PA, Drenser KA, Trese MT, Capone A Jr.
    Ophthalmology. ELSEVIER SCIENCE INC 123 (8) 1802 - 1808 0161-6420 2016/08 [Refereed]
     
    Purpose: To determine the feasibility and safety of bilateral simultaneous vitreoretinal surgery in pediatric patients. Design: International, multicenter, interventional, retrospective case series. Participants: Patients 17 years of age or younger from 24 centers worldwide who underwent immediate sequential bilateral vitreoretinal surgery (ISBVS)-defined as vitrectomy, scleral buckle, or lensectomy using the vitreous cutter-performed in both eyes sequentially during the same anesthesia session. Methods: Clinical history, surgical details and indications, time under anesthesia, and intraoperative and postoperative ophthalmic and systemic adverse events were reviewed. Main Outcome Measures: Ocular and systemic adverse events. Results: A total of 344 surgeries from 172 ISBVS procedures in 167 patients were included in the study. The mean age of the cohort was 1.3 +/- 2.6 years. Nonexclusive indications for ISBVS were rapidly progressive disease (74.6%), systemic morbidity placing the child at high anesthesia risk (76.0%), and residence remote from surgery location (30.2%). The most common diagnoses were retinopathy of prematurity (ROP; 72.7% [P < 0.01]; stage 3, 4.8%; stage 4A, 44.4%; stage 4B, 22.4%; stage 5, 26.4%), familial exudative vitreoretinopathy (7.0%), abusive head trauma (4.1%), persistent fetal vasculature (3.5%), congenital cataract (1.7%), posterior capsular opacification (1.7%), rhegmatogenous retinal detachment (1.7%), congenital X-linked retinoschisis (1.2%), Norrie disease (2.3%), and viral retinitis (1.2%). Mean surgical time was 143 +/- 59 minutes for both eyes. Higher ROP stage correlated with longer surgical time (P = 0.02). There were no reported intraoperative ocular complications. During the immediate postoperative period, 2 eyes from different patients demonstrated unilateral vitreous hemorrhage (0.6%). No cases of endophthalmitis, choroidal hemorrhage, or hypotony occurred. Mean total anesthesia time was 203 +/- 87 minutes. There were no cases of anesthesia-related death, malignant hyperthermia, anaphylaxis, or cardiac event. There was 1 case of reintubation (0.6%) and 1 case of prolonged oxygen desaturation (0.6%). Mean follow-up after surgery was 103 weeks, and anatomic success and globe salvage rates were 89.8% and 98.0%, respectively. Conclusions: This study found ISBVS to be a feasible and safe treatment paradigm for pediatric patients with bilateral vitreoretinal pathologic features when repeated general anesthesia is undesirable or impractical. (C) 2016 by the American Academy of Ophthalmology.
  • Kondo H, Matsushita I, Nagata T, Hayashi T, Kakinoki M, Uchio E, Kondo M, Ohji M, Kusaka S.
    Hum Genome Var . Springer Nature 3 16018 - 16018 2016/07 [Refereed]
     
    Stickler syndrome is an inherited connective tissue disorder that affects the eyes, cartilage and articular tissues. The phenotypes of Stickler syndrome include congenital high myopia, retinal detachment, premature joint degeneration, hearing impairment and craniofacial anomalies, such as cleft palate and midline facial hypoplasia. The disease is genetically heterogeneous, and the majority of the cases are caused by mutations in the COL2A1 gene. We examined 40 Japanese patients with Stickler syndrome from 23 families to determine whether they had mutations in the COL2A1 gene. This analysis was conducted by examining each patient's genomic DNA by Sanger sequencing. Five nonsense, 4 splicing and 8 deletion mutations in the COL2A1 gene were identified, accounting for 21 of the 23 families. Different mutations of the COL2A1 gene were associated with similar phenotypes but with different degrees of expressivity.
  • Imaizumi A, Kusaka S, Takaesu S, Sawaguchi S, Shimomura Y.
    Case Rep Ophthalmol . S. Karger AG 7 (1) 223 - 229 1663-2699 2016/04 [Refereed]
     
    Severe forms of Coats' disease are often associated with total retinal detachment, and a differential diagnosis from retinoblastoma is critically important. In such eyes, laser- and/or cryoablation is often ineffective or sometimes impossible to perform. We report a case of advanced Coats' disease in which a rapid pathological examination of subretinal fluid was effective for the diagnosis, and external subretinal drainage combined with vitrectomy was effective in preserving the eye.
  • 未熟児網膜症に対する水晶体温存硝子体術後の水晶体透明性
    立花 都子; 日下 俊次; 阿部 考助; 森本 壮; 國吉 一樹; 杉岡 孝二; 岩橋 千春; 不二門 尚; 下村 嘉一
    日本眼科学会雑誌 (公財)日本眼科学会 120 (臨増) 192 - 192 0029-0203 2016/03
  • 広角眼底観察システム用曇り防止装置の臨床応用
    日下 俊次; 辻岡 大志; 立花 都子; 小池 英子; 檜垣 史郎; 下村 嘉一
    眼科臨床紀要 8 (10) 757 - 757 1882-5176 2015/10
  • Reduced rod electroretinograms in carrier parents of two Japanese siblings with autosomal recessive retinitis pigmentosa associated with PDE6B gene mutations.
    Kuniyoshi K, Sakuramoto H, Yoshitake K, Ikeo K, Furuno M, Tsunoda K, Kusaka S, Shimomura Y, Iwata T.
    Doc Ophthalmol. 131 (1) 71 - 79 2015/08
  • Novel nonsense and splice site mutations in CRB1 gene in two Japanese patients with early-onset retinal dystrophy
    Kuniyoshi K, Ikeo K, Sakuramoto H, Furuno M, Yoshitake K, Hatsukawa Y, Nakao A, Tsunoda K, Kusaka S, Shimomura Y, Iwata T.
    Doc Ophthalmol . Springer 130 (1) 49 - 55 2015/01
  • Fukumitsu M, Matsumoto F, Tachibana K, Koike E, Tanabe F, Abe K, Kusaka S, Onuma K.
    JAPANESE ORTHOPTIC JOURNAL Japan Society of Engineering Geology 43 137 - 143 0387-5172 2014/12 [Refereed]
     
    [Purpose] We reported two cases of anisometropic amblyopia with Mittendorf spot that achieved good visual acuity and stereo acuity by nonsurgical amblyopic treatment.
    [Cases] The patient in case 1 was a 3-year-old boy with a 0.8 mm-diameter Mittendorf spot in the left eye. Visual acuity after cycloplegia was RV = (1.0×+3.50 D) and LV = (0.5×+5.00 D, cyl-2.50 D 60°). Higher order aberrations by Wave-Front Analyzer KR-1W® (TOPCON) were 0.052 μm (right) and 0.826 μm (left). After refractive correction and occlusion therapy, he achieved the best corrected visual acuity of 1.0 and stereo acuity of 60 second of arc.
      The patient in case 2 was an 11-year-old girl with a 1.6 mm-diameter Mittendorf spot in the right eye. Visual acuity after cycloplegia was RV = (0.6×+2.50 D, cyl-1.50 D 155°) and LV = (1.5×+0.50 D, cyl-0.75 D 180°). Higher order aberrations were 0.231 μm (right) and 0.108 μm (left). After refractive correction and occlusion therapy, she obtained the best corrected visual acuity of 1.2 and stereo acuity of 60 second of arc.
    [Conclusion] In amblyopic eyes with Mittendorf spot and large amount of higher order aberrations, amblyopic treatment could be effective even if the eyes are anisometropic.
  • Minami T, Kuniyoshi K, Kusaka S, Sugioka K, Sakuramoto H, Sakamoto M, Izu A, Wada N, Shimomura Y.
    Case Rep Ophthalmol. S. Karger AG 5 (3) 318 - 324 1663-2699 2014/10 [Refereed]
     
    Purpose: To report our findings in an infant with Peters anomaly type II whose retinopathy of prematurity (ROP) was treated with an anti-VEGF agent and surgeries. Case Report: A male infant weighing 548 g was born prematurely at 23 weeks and 1 day with corneal opacity and shallow anterior chambers in both eyes. At the postmenstrual age of 35 weeks and 3 days, the infant was tentatively diagnosed with stage 3 ROP because of a dilated tunica vasculosa lentis and ultrasonographic findings. The boy was treated with bilateral intravitreal injections of bevacizumab (IVB) because laser photocoagulation of the retina could not be performed due to the corneal opacity. The retina in the right eye detached 3 times, namely 5 days, 16 days, and 7 months after the IVB encircling the scleral buckle and a vitrectomy with endolaser photocoagulation were therefore required. In his left eye, the retina was reattached after the initial IVB, and no additional treatment was required. ROP was not reactivated in both eyes until the last examination at the age of 2 years and 6 months. Conclusions: Our results showed that IVB is a useful treatment for ROP in patients with Peters anomaly. However, a retinal detachment can be a complication after IVB. The optimal timing of IVB for ROP in infants with hazy media needs to be determined.
  • 岡本 紀夫, 日下 俊次, 松本 長太, 不二門 尚, 下村 嘉一
    眼科 金原出版(株) 56 (9) 1123 - 1128 0016-4488 2014/08 
    症例は86歳女性で、74歳時に左眼の白内障手術・黄斑円孔手術、81歳時に白内障手術の既往があった。主訴は目の前に丸い黒いものが飛ぶであった。視力は右眼0.8、左眼0.5、眼圧は右眼10.5mmHg、左眼16.5mmHgであった。眼底検査では右眼に後部硝子体剥離、左眼に黄斑部の異常反射を認め、光干渉断層像(OCT)では右眼は正常、左眼に網膜色素上皮の乱れを認めた。初診2ヵ月後に風呂上りにギザギザが見えて再診し、眼底検査では右眼の下耳側網膜分枝に塞栓を認め、その領域の網膜が白濁していた。OCTでは網膜白濁の部位は肥厚し、網膜内層の高反射を認め、静的視野検査で白濁部位に一致して網膜感度の低下を認めた。バイアスピリン内服を開始した。初診3年後再診時の眼底検査では塞栓が残存し、その末梢の網脈動脈にバイパス形成を認め、OCTでは白濁部位の網膜厚、ganglion cell complex厚の菲薄化を認めた。
  • Longitudinal clinical course of three Japanese patients with Leber congenital amaurosis/early-onset retinal dystrophy with RDH12 mutation.
    Kuniyoshi K, Sakuramoto H, Yoshitake K, Abe K, Ikeo K, Furuno M, Tsunoda K, Kusaka S, Shimomura Y, Iwata T.
    Doc Ophthalmol. Springer 128 (3) 219 - 228 2014/06
  • Kuniyoshi K, Sugioka K, Sakuramoto H, Kusaka S, Wada N, Shimomura Y.
    Jpn J Ophthalmol. Springer Science and Business Media LLC 58 (3) 237 - 243 0021-5155 2014/05
  • Tahija SG, Hersetyati R, Lam GC, Kusaka S, McMenamin PG.
    Br J Ophthalmol. BMJ PUBLISHING GROUP 98 (4) 507 - 512 0007-1161 2014/04 [Refereed]
     
    Aim To evaluate vascularisation of the peripheral retina using fluorescein angiography (FA) digital recordings of infants who had been treated with intravitreal bevacizumab (IVB) as sole therapy for zone I and posterior zone II retinopathy of prematurity (ROP). Methods A retrospective evaluation was performed of medical records, RetCam fundus images and RetCam fluorescein angiogram videos of 10 neonates (20 eyes) who received intravitreal bevacizumab injections as the only treatment for zone I and posterior zone II ROP between August 2007 and November 2012. Results All eyes had initial resolution of posterior disease after IVB injection as documented by RetCam colour fundus photographs. Using a distance of 2 disc diameters from the ora serrata to vascular termini as the upper limit of allowable avascular retina in children, the FA of these infants demonstrated that 11 of 20 eyes had not achieved normal retinal vascularisation. Conclusions Although bevacizumab appears effective in bringing resolution of zone I and posterior zone II ROP and allowing growth of peripheral retinal vessels, in our series of 20 eyes, complete normal peripheral retinal vascularisation was not achieved in half of the patients.
  • Kodama A; Sugioka K; Kusaka S; Matsumoto C; Shimomura Y
    BMC Ophthalmol. Springer Nature 14 36 - 36 2014/03 
    BACKGROUND: The exact pathogenetic mechanisms of Coats' disease remain unknown. In this report, we show two cases of Coats' disease that achieved a favorable prognosis with the combined treatment of intravitreal bevacizumab (IVB) injection prior to photocoagulation, although both initially resisted photocoagulation therapy. CASE PRESENTATIONS: Case 1 was a 15-year-old boy with initial visual acuity of 0.4 OD. At the temporal retina, aneurysms and abnormal telangiectatic vessels were observed. Hard exudates and an exudative retinal detachment extended to the fovea. He was diagnosed as having Coats' disease at stage 3A and we performed laser photocoagulation as an initial approach to treat peripheral aneurysms and telangiectatic vessels. After the treatment, the exudative retinal detachment was eased and visual acuity improved to 1.0; however, recurrence occurred after 5 months. The exudative change was resistant against laser photocoagulation therapy and we therefore added IVB as an adjuvant before photocoagulation. Fourteen days after IVB injection phased laser photocoagulation was given to cover the abnormal capillaries, aneurysms and the leakage area spotted in FA. A good prognosis was obtained with decreased exudation and improved visual acuity.Case 2 was an 11-year-old boy with decreased visual acuity of 0.15 OS at the initial visit. Hard exudates, retinal edema and serous retinal detachment were seen at the macula and peripheral retina. Fluorescein angiography revealed telangiectatic capillaries at the temporal retina. Our diagnosis was Coats' disease at stage 3A. Extensive photocoagulation was performed as an initial treatment to the lesion. However, the exudative change was severe and resistant against the photocoagulation treatment. Therefore, we added IVB as an adjuvant before photocoagulation. Exudative change in the retina seemed to be eased 7 days after IVB injection, therefore, phased laser phototherapy was added to cover the abnormal capillaries. After the combination therapy, exudative change was remarkably ameliorated and better visual acuity was achieved. CONCLUSION: Bevacizumab is considered an effective adjuvant for Coats' disease with exudative change resistant to retinal photocoagulation therapy.
  • Baba T, Miyake A, Yamasaki A, Kusaka S, Inoue Y.
    臨床眼科 医学書院 68 (3) 339 - 343 0370-5579 2014/03 [Refereed]
  • Imaizumi A, Kusaka S, Noguchi H, Shimomura Y, Sawaguchi S.
    Am J Ophthalmol Case Rep. ELSEVIER SCIENCE INC 157 (2) 384 - 389 0002-9394 2014/02 [Refereed]
     
    PURPOSE: To evaluate the efficacy of perfluoro-n-octane as a postoperative short-term tamponade after vitrectomy in pediatric cases with complex retinal detachment (RD) and proliferative vitreoretinopathy (PVR). DESIGN: Prospective, noncomparative, interventional case series. METHODS: The medical records of 10 eyes of 9 children (6 boys and 3 girls), whose age ranged from 3 months to 11 years, with a median of 7.5 months, were reviewed. The cause of the PVR was retinopathy of prematurity (7 eyes of 6 patients); familial exudative vitreoretinopathy; or tractional RD associated with congenital optic nerve anomalies,(1) and persistent fetal vasculature. Perfluoro-n-octane was injected into the eyes at the primary surgery in 2 eyes and at the repeat surgeries in 8 eyes. The perfluoro-n-octane was removed after 1 to 4 postoperative weeks. The patients were followed for 5 to 43 months. RESULTS: At the last examination, the retinas were reattached in 8 eyes (80%). In the other two eyes, a retinal attachment was not obtained. Postoperatively, the best-corrected visual acuity improved from hand motion to 0.1 in 1 eye and could not be measured in the other 9 patients because of their ages. No apparent adverse events related to the use of perfluoro-n-octane were noted.. CONCLUSIONS: Although cautions should be exercised regarding potential mechanical retinal injuries by heavy liquids in the eye, short-term perfluoro-n-octane tamponade was effective in pediatric cases with severe PVR in which retinal reattachment is considered to be difficult with
  • アリピプラゾールによる一過性の近視化の1例
    岡本 紀夫, 日下 俊次, 長井 紀章, 伊藤 吉將, 下村 嘉一
    眼科臨床紀要 眼科臨床紀要会 6 (11) 903 - 905 2013/11
  • Sugioka K, Kodama A, Okada K, Iwata M, Yoshida K, Kusaka S, Matsumoto C, Kaji H, Shimomura Y.
    Exp Eye Res. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 115 13 - 21 0014-4835 2013/10 
    Transforming growth factor-beta (TGF-beta) is one of the main epithelial mesenchymal transition (EMT)-inducing factors. In general, TGF-beta-induced EMT promotes cell migration and invasion. TGF-beta also acts as a potent regulator of pericellular proteolysis by regulating the expression and secretion of plasminogen activators. Urokinase-type plasminogen activator (uPA) is a serine protease that binds to its cell surface receptor (uPAR) with high affinity. uPA binding to uPAR stimulates uPAR's interaction with transmembrane proteins, such as integrins, to regulate cytoskeletal reorganization and cell migration, differentiation and proliferation. However, the influence of TGF-beta and the uPA/uPAR system on EMT in retinal pigment epithelial (RPE) cells is still unclear. The purpose of this study was to determine the effect of TGF-beta 2, which is the predominant isoform in the retina, and the uPA/uPAR system on RPE cells. In this study, we first examined the effect of TGF-beta 2 and/or the inhibitor of uPA (u-PA-STOP (R)) on the proliferation of a human retinal pigment epithelial cell line (ARPE-19 cells). Treatment with TGF-beta 2 or u-PA-STOP (R) suppressed cell proliferation. Combination treatment of TGF-beta 2 and u-PA-STOP (R) enhanced cell growth suppression. Furthermore, western blot analysis, fibrin zymography and real-time reverse transcription PCR showed that that TGF-beta 2 induced EMT in ARPE-19 cells and that the expression of uPA and uPAR expression was up-regulated during EMT. The TGF-beta inhibitor SB431542 suppressed TGF-beta 2-stimulated uPA expression and secretion but did not suppress uPAR expression. Furthermore, we seeded ARPE-19 cells onto Transwell chambers and allowed them to invade the collagen matrix in the presence of TGF-beta 2 alone or with TGF-beta 2 and u-PA-STOP (R). TGF-beta 2 treatment induced ARPE-19 cell invasion into the collagen gel. Treatment with a combination of TGF-beta 2 and the uPA inhibitor strongly inhibited ARPE-19 cell invasion compared with treatment with TGF-beta 2 alone. Furthermore, the interaction between uPA and ARPE-19 cells was analyzed using a surface plasmon biosensor system. The binding of uPA to ARPE-19 cells was observed. In addition, TGF-beta 2 significantly promoted the binding activity of uPA to ARPE-19 cells in a time-dependent or cell-number-dependent fashion. These results indicate that TGF-beta-induced EMT-associated phenotype changes in ARPE-19 cells and the invasiveness of ARPE-19 cells into a collagen gel matrix are mediated, at least in part, by uPA. (C) 2013 Elsevier Ltd. All rights reserved.
  • 日下 俊次
    日本眼科学会雑誌 公益財団法人日本眼科学会 117 (3) 311 - 314 0029-0203 2013/03
  • Kondo H, Kusaka S, Yoshinaga A, Uchio E, Tawara A, Tahira T.
    Mol. Vis. MOLECULAR VISION 19 476 - 485 1090-0535 2013/02 
    Purpose: Retinopathy of prematurity (ROP) is a complex disease with a genetic predisposition, but little is known about its genetic background. It has a clinical resemblance to familial exudative vitreoretinopathy (FEVR), a hereditary disease characterized by defects in the development of retinal vessels. Several studies have suggested that mutations in the causative genes for FEVR may account for a proportion of advanced ROP, but conflicting data have also been reported for some variants. To address the possibility of genetic involvement of FEVR genes in ROP, we performed comprehensive sequence analyses of 53 Japanese patients with advanced ROP for the FEVR-causing genes. Methods: Peripheral blood DNA was obtained from 53 patients referred to our hospitals for retinal surgery. Polymerase chain reaction followed by direct sequencing of the coding regions of the known FEVR-causing genes (FZD4, LRP5, TSPAN12, and NDP) and a noncoding exon of the NDP gene was performed. Possible pathogenicity of the sequence changes were analyzed by orthologous protein sequence alignment and by computational predictions. Results: We identified six different nonsynonymous DNA variants in the coding region of either the FZD4 gene (p.H69Y, p.R127H, and p.Y211H) or the LRP5 gene (p.R1219H, p.H1383P, and p.T1540M) in seven patients. The corresponding codons of these changes were highly conserved among species, and these changes were predicted to be pathogenic by at least two of four computational prediction programs. No such changes were found in the TSPAN12 and NDP genes. Conclusions: Six possibly pathogenic variants of FZD4 or LRP5 were found in seven advanced ROP patients. Although these variants do not yet provide definitive evidence that they are causal, the results imply a role of the FZD4 and LRP5 genes in the development of advanced ROP.
  • 抗VEGF療法が奏効した新生児網膜血管異常の2例
    藤田 陽子, 塚本 晶子, 田邉 美香, 石田 貴美子, 江内田 寛, 吉川 洋, 日下 俊次, 石橋 達朗
    眼科手術 日本眼科手術学会誌 26 (1) 121 - 127 2013/01
  • Iwahashi-Shima C, Miki A, Hamasaki T, Otori Y, Matsushita K, Kiuchi Y, Okada M, Kusaka S.
    Retina Ovid Technologies (Wolters Kluwer Health) 32 (8) 1636 - 1642 0275-004X 2012/09
  • Sakaguchi H, Ohji M, Oshima Y, Ikuno Y, Gomi F, Maeda N, Kamei M, Kusaka S, Nishida K.
    Clin Ophthalmol. Informa UK Limited 6 1281 - 1286 2012/08 
    BACKGROUND: To assess time-course changes in best-corrected visual acuity (BCVA) up to 5 years after vitrectomy to treat idiopathic full-thickness macular holes (MHs) and identify the relationship of the changes to postoperative complications. METHODS: Twenty-three consecutive patients with an idiopathic MH underwent vitrectomy without adjuvant treatment. BCVA and complications were assessed postoperatively. RESULTS: Twenty-two of 23 (95.7%) MHs closed after the first surgery, with a final anatomic success rate of 100%. The time course of the BCVA was analyzed in 20 cases in which data were obtained for over 5 years. The BCVA improved by 0.43 logarithm of the minimum angle of resolution (logMAR) unit 6 months postoperatively (P < 0.001) and continuously improved by 0.05, 0.06, and 0.07 logMAR units between 6 months and 1 year, 1 year and 3 years (by 0.11 logMAR unit between 6 months and 3 years; P = 0.049), and 3 years and 5 years (P = 0.018) postoperatively, respectively. Macular complications developed in seven (35%) of the 20 cases; the mean BCVA at 5 years in these cases was significantly (P < 0.001) worse than in cases without complications. CONCLUSION: The BCVA might improve gradually for 5 years after vitrectomy to treat MHs. However, the macular complications that can develop postoperatively could limit that possibility.
  • Kiboshi N, Hori Y, Shimojo H, Kusaka S, Fujikado T.
    Folia Jpn de Ophthalmol Clin. 眼科臨床紀要会 5 (3) 216 - 219 1882-5176 2012/03
  • Sato T, Wada K, Arahori H, Kuno N, Imoto K, Iwahashi-Shima C, Kusaka S.
    Am J Ophthalmol. Elsevier BV 153 (2) 327 - 333.e1 0002-9394 2012/02
  • 特集 眼科診療:5年前の常識は,現在の非常識! 4 網膜・硝子体疾患 ■診断・治療 未熟児網膜症の治療
    佐藤 達彦, 日下 俊次
    臨床眼科 医学書院 65 (11) 299 - 301 2011/10
  • Kondo H, Kusaka S, Yoshinaga A, Uchio E, Tawara A, Hayashi K, Tahira T.
    Am J Ophthalmol. Elsevier BV 151 (6) 1095 - 1100.e1 0002-9394 2011/06 
    • Purpose: To search for mutations in the TSPAN12 gene in 90 Japanese probands with familial exudative vitreoretinopathy (FEVR) and their family members and to determine the types and frequencies of the mutations. • Design: Laboratory investigation and clinical case analyses. • Methods: Direct sequencing after polymerase chain reaction of the coding exons of TSPAN12 was performed for 90 probands with FEVR and some of their family members. The clinical signs and symptoms that were characteristic of individuals with TSPAN12 mutations were determined. • Results: Three families were found to carry 2 mutations in TSPAN12. One of these mutations was a new missense change, L245P, and the other was an already reported nonsense mutation, L140X, in 2 families. Mutations in TSPAN12 accounted for 3% of Japanese FEVR patients and 8% of the FEVR families who did not have mutations in any of the known FEVR genes, FZD4, LRP5, and NDP. The clinical signs and symptoms varied among the patients, but the retinal findings with TSPAN12 mutations were not different from those with mutations in the known FEVR-causing genes. • Conclusions: Mutant TSPAN12 is responsible for approximately 3% of FEVR patients in Japan. The results provide further evidence that mutations in TSPAN12 are FEVR causing and that the gene products most likely play a role in the development of retinal vessels. © 2011 Elsevier Inc. All rights reserved.
  • Kitaguchi Y, Kusaka S, Yamaguchi T, Mihashi T, Fujikado T.
    Clin Ophthalmol. Informa UK Limited 5 345 - 351 2011/03 
    PURPOSE: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD). DESIGN: Observational case reports. METHODS: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained. RESULTS: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea. CONCLUSION: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.
  • Sato T, Shima C, Kusaka S.
    Am J Ophthalmol Elsevier BV 151 (2) 353 - 357.e1 0002-9394 2011/02
  • Murakami Y, Kusaka S, Hayashi N, Soga K, Fujikado T.
    J AAPOS. Elsevier BV 14 (6) 530 - 531 1091-8531 2010/12 [Refereed]
  • Kandori M, Saishin Y, Kusaka S, Shimojyo H, Otori Y, Tano Y.
    Acta Ophthalmol. Wiley 88 (7) e289 - e290 1755-375X 2010/11
  • Kusaka S, Futamura H.
    Retina Ovid Technologies (Wolters Kluwer Health) 30 (8) 1318 - 1319 0275-004X 2010/09 [Refereed]
  • Wakabayashi T, Fujiwara M, Sakaguchi H, Kusaka S, Oshima Y.
    Ophthalmology. Elsevier BV 117 (9) 1814 - 1824 0161-6420 2010/09 
    Purpose: To evaluate reconstructive changes in foveal microstructures and identify a correlation with visual outcomes in eyes with surgically closed macular holes (MHs). Design: Retrospective, consecutive, observational case series. Participants: Forty eyes (40 patients) with surgically closed MHs. Methods: Spectral-domain optical coherence tomography (SD-OCT) was performed to assess the foveal microstructural changes 3 and 12 months postoperatively. The correlation between the postoperative best-corrected visual acuity (BCVA) and the integrity of the foveal photoreceptor layer was evaluated. Main Outcome Measures: The integrity of the back-reflection lines from the photoreceptor inner segment (IS) and outer segment (OS) junction and the external limiting membrane (ELM) on SD-OCT images and the BCVA measured on the same day. Results: The integrity of the foveal photoreceptor layer was the only postoperative SD-OCT finding significantly associated with the 3-month BCVA (r=0.483; P=0.002). The eyes were categorized into 3 groups according to restoration of the IS/OS junction and ELM signals: 6 eyes (15%) in group A with complete restoration of the IS/OS junction and the ELM; 26 eyes (65%) in group B with a disrupted IS/OS junction and intact ELM; and 8 eyes (20%) in group C with disruption or loss of the IS/OS junction and the ELM. Although the baseline BCVA did not differ significantly (P=0.137) among groups, the mean 3-month BCVA values in groups A and B, both with reconstructed ELM with or without a restored photoreceptor IS/OS, were significantly better than in group C (P<0.05); the difference between groups A and B was not significant (P>0.05). Groups A (P=0.029) and B (P<0.001) had significant visual improvement at 12 months; group C did not have marked visual recovery. Fourteen eyes (54%) in group B had subsequent realignment of the foveal photoreceptor IS/OS; no eyes in group C had a restored IS/OS at 12 months. The presence of the ELM at 3 months is a critical structural feature significantly correlated with the BCVA at 12 months (r=0.832, P<0.001). Conclusions: Reconstruction of the foveal ELM in the early postoperative period helps predict subsequent restoration of the foveal photoreceptor layer and the potential for better visual outcomes.
  • Sato T, Kusaka S, Shimojo H, Fujikado T.
    Ophthalmology Elsevier BV 116 (11) 2165 - 2169 0161-6420 2009/11
  • Sato T, Kusaka S, Shimojo H, Fujikado T.
    Ophthalmology Elsevier BV 116 (9) 1599 - 1603 0161-6420 2009/09
  • Kitaguchi Y, Fujikado T, Kusaka S, Yamaguchi T, Mihashi T, Tano Y.
    Am J Ophthalmol. Elsevier BV 148 (1) 97 - 104.e2 0002-9394 2009/07 
    PURPOSE: To examine and observe the subtle retinal injuries caused by a titanium:sapphire laser with a high-resolution adaptive optics (AO) fundus camera and with Fourier-domain optical coherence tomography (FD-OCT). DESIGN: Observational case series. METHODS: Four eyes of 2 individuals who experienced an accidental exposure to reflected light from a titanium:sapphire laser were examined. High-resolution retinal images were obtained with the AO fundus camera and by FD-OCT, and the images were compared with the findings obtained by standard clinical tests, including the Amsler test and fluorescein angiography (FA). RESULTS: The photoreceptor mosaic was absent in a localized area of the fovea in the images obtained by the AO fundus camera, and the photoreceptor outer segments (OS) were disrupted at the corresponding area in the FD-OCT images. The changes were detected not only in the symptomatic eye but also in the asymptomatic fellow eye in both patients. In 3 eyes, the geographic dark area in the AO image decreased during the follow-up examinations. CONCLUSIONS: Very small, localized photoreceptor disruptions can be detected in patients with minimal titanium:sapphire laser injury by cross-sectional imaging using OCT, but their extent was delineated more precisely by en face AO imaging. Because the area of the photoreceptor disruption is very small, especially in the nonsymptomatic fellow eye, it is strongly recommended that laser workers--even those without visual symptoms--be examined by FD-OCT, an AO camera, or both if they have not worn protective goggles while using a laser.
  • Oshima Y, Shima C, Wakabayashi T, Kusaka S, Shiraga F, Ohji M, Tano Y.
    Ophthalmology Elsevier BV 116 (5) 927 - 938 0161-6420 2009/05
  • Shima C, Kusaka S, Kondo H, Hasebe H, Fujikado T, Tano Y.
    Arch Ophthalmol. American Medical Association (AMA) 127 (4) 579 - 579 0003-9950 2009/04
  • Wakabayashi T, Oshima Y, Fujimoto H, Murakami Y, Sakaguchi H, Kusaka S, Tano Y.
    Ophthalmology. ELSEVIER SCIENCE INC 116 (3) 519 - 528 0161-6420 2009/03 
    Purpose: To evaluate foveal microstructural changes in eyes with anatomically successful repair of rhegmatogenous retinal detachments (RRDs). Design: Retrospective, consecutive, observational case series. Participants: Fifty-three eyes of 51 consecutive patients with macula-on RRDs (15 eyes) or macula-off RRDs (38 eyes) after anatomically successful surgical repair. Methods: A microscopic fundus examination was conducted followed by Fourier-domain optical coherence tomography (FD-OCT) to assess the postoperative foveal microstructure. The correlation between the postoperative best-corrected visual acuity (BCVA) and microstructural findings at the fovea was evaluated. Main Outcome Measures: Images of the foveal microstructure obtained by FD-OCT and the BCVA measured on the same day. Results: We obtained FD-OCT images a mean of 10.3 +/- 7.3 months (range, 1-25) postoperatively. Foveal anatomic abnormalities were detected in 33 eyes (62%); disruption of the junction between the photoreceptor inner and outer segments (IS/OS) in 23 eyes (43%), of which 9 eyes (39%) had a disrupted external limiting membrane (ELM); residual subretinal fluid in 6 eyes (11%), epiretinal membranes in 12 eyes (23%), and cystoid macular edema in 2 eyes (4%). Disruption of the photoreceptor IS/OS junction was observed only in macula-off eyes, whereas other microstructural abnormalities were observed in both macula-on and macula-off eyes. In preoperative macula-off eyes, the postoperative BCVA was significantly correlated with the integrity of the photoreceptor IS/OS and ELM signals detected by FD-OCT postoperatively (r = 0.805; P<0.001). Of the 16 eyes followed by FD-OCT, the photoreceptor IS/OS junction was restored in 7 (64%) of the 11 eyes with a disrupted back-reflection line from the IS/OS junction, but without disrupted ELM signals at the initial examination. Of the 5 eyes with disrupted back-reflection lines from both IS/OS junction and ELM at the initial examination, the photoreceptor layer was not restored completely during the follow-up period in any eyes. Conclusions: After anatomically successful RRD repair, FD-OCT is a valuable, noninvasive tool for evaluating foveal microstructural changes. The integrity of the photoreceptor IS/OS junction and ELM signals detected by FD-OCT may account for visual restoration in patients with preoperative macula-off RRDs. Preservation of the ELM postoperatively may predict the subsequent restoration of the photoreceptor layer. Financial Disclosure(s): Proprietary or commercial disclosures may be found after the references. Ophthalmology 2009; 116:519-528 (C) 2009 by the American Academy of Ophthalmology.
  • Sato T, Kusaka S, Hashida N, Saishin Y, Fujikado T, Tano Y.
    Br J Ophthalmol. BMJ 93 (1) 96 - 103 0007-1161 2009/01
  • Kusaka S, Shima C, Wada K, Arahori H, Shimojyo H, Sato T, Fujikado T.
    Br J Ophthalmol. BMJ 92 (11) 1450 - 1455 0007-1161 2008/11
  • Fang X, Sakaguchi H, Gomi F, Oshima Y, Sawa M, Tsujikawa M, Ikuno Y, Kamei M, Kusaka S, Tano Y.
    Acta Ophthalmol. WILEY-BLACKWELL 86 (7) 800 - 805 1755-375X 2008/11 [Refereed]
     
    Purpose: To assess the efficacy, duration of effect and safety of one intravitreal injection of bevacizumab in diabetic macular oedema (DMO). Methods: Bevacizumab (1 mg/0.04 ml) was injected intravitreally into eyes with DMO (29 with and nine without previous treatments). Best corrected visual acuity (BCVA), intraocular pressure and central retinal thickness (CRT) were measured; slit-lamp examination, macular biomicroscopy, optical coherence tomography and fluorescein angiography were performed before and at 2-4, 8 and 12 weeks post-injection. Best corrected VA and CRT were analysed in both groups. Results: In the non-pretreated group, mean BCVA improved from 0.76 +/- 0.33 (baseline) to 0.57 +/- 0.30 and 0.54 +/- 0.27 at 2-4 weeks and 8 weeks post-injection, respectively (p = 0.02, p = 0.014, paired t-test). Mean CRT decreased from 632.4 +/- 196.0 mu m (baseline) to 392.3 +/- 113.6 mu m and 370.4 +/- 141.7 mu m at the same time-points, respectively (p = 0.01, p = 0.01). There was no difference in BCVA or CRT at 12 weeks. In the pretreated group, mean BCVA improved from 0.62 +/- 0.30 (baseline) to 0.53 +/- 0.33 at 2-4 weeks post-injection (p = 0.01), and mean CRT decreased from 583.9 +/- 180.7 mu m (baseline) to 404.1 +/- 197.9 mu m at 2-4 weeks post-injection (p < 0.001). Mean BCVA was unchanged at 8 weeks and 12 weeks post-injection, although mean CRT remained lower at 8 weeks (p = 0.004). No ocular or systemic side-effects developed during follow-up. Conclusions: One intravitreal injection of bevacizumab for DMO seems to be effective and safe in both eyes that have been treated previously and eyes that have not. The therapeutic effect is temporary and repeat treatment may be needed.
  • Murakami Y, Kusaka S, Oshima Y, Tano Y.
    Retina. LIPPINCOTT WILLIAMS & WILKINS 28 (9) 1357 - 1360 0275-004X 2008/10 [Refereed]
  • Wakabayashi T, Oshima Y, Sakaguchi H, Ikuno Y, Miki A, Gomi F, Otori Y, Kamei M, Kusaka S, Tano Y.
    Ophthalmology. ELSEVIER SCIENCE INC 115 (9) 1571 - 1580 0161-6420 2008/09 [Refereed]
     
    Purpose: To evaluate the biologic efficacy of intravitreal bevacizumab (IVB) for iris neovascularization (INV) or neovascular glaucoma (NVG) in patients with ischemic retinal disorders. Design: Retrospective, consecutive, interventional case series. Participants: Thirty patients (41 eyes) with INV or NVG secondary to ischemic retinal disorders. Methods: Patients received IVB (1 mg) as the initial treatment for INV or NVG and were followed up for at least 6 months. Ophthalmic evaluations included measurement of visual acuity and intraocular pressure (IOP), a complete ophthalmic examination, and fluorescein angiography. Patients were divided into 3 subgroups: INV without elevated IOP (INV group), NVG with an open angle (O-NVG group), and NVG with angle closure (C-NVG group) for outcomes analysis. Main Outcome Measures: The controllability of IOP by IVB, incidence of recurrence, and requirement for surgery to treat NVG. Results: No significant ocular or systemic adverse events developed during follow-up (range, 6-22 months; mean, 13.3 months). The mean IOP levels were 14.7, 31.2, and 44.9 mmHg at baseline in the INV, O-NVG, and C-NVG groups, respectively. In the INV group (9 eyes), the INV regressed or resolved after 1 injection. Iris neovascularization recurred in 4 eyes by 6 months and stabilized after repeated injections without IOP elevation. In the O-NVG group (17 eyes), rapid neovascular regression with successful IOP normalization (<= 21 mmHg) occurred in 12 eyes (71 %) within 1 week after 1 injection. Five (29%) of the 17 eyes required surgery by 6 months despite repeated IVB injections, and a total of 7 eyes (41 %) underwent surgery during follow-up. In the C-NVG group (15 eyes), IVB caused INV resolution but failed to lower the IOP. Fourteen (93%) of 15 eyes required surgery by 2 months after initial IVB and achieved IOP stabilization. The mean interval between IVB and surgery was significantly shorter in the C-NVG group than in the O-NVG group (P<0.001). Conclusions: Intravitreal bevacizumab is well tolerated, effectively stabilized INV activity, and controlled IOP in patients with INV alone and early-stage NVG without angle closure. In advanced NVG, IVB cannot control IOP but may be used adjunctively to improve subsequent surgical results. Further evaluation in controlled randomized studies is warranted.
  • Shima C, Sakaguchi H, Gomi F, Kamei M, Ikuno Y, Oshima Y, Sawa M, Tsujikawa M, Kusaka S, Tano Y.
    Acta Ophthalmol. BLACKWELL PUBLISHING 86 (4) 372 - 376 1755-375X 2008/06 [Refereed]
     
    Purpose: To report complications in patients after intravitreal injection of bevacizumab to treat ocular diseases associated with vascular endothelial growth factor. Methods: We retrospectively reviewed the systemic and ocular complications that developed within 2 months of each intravitreal injection of bevacizumab in 707 patients (1300 injections) with intraocular neovascularization or macular oedema. Results: Nine ocular (1.27%) and eight systemic (1.13%) complications occurred in 707 patients. The ocular complications included corneal abrasion (n = 2), chemosis (n = 2), lens injury (n = 1), ocular inflammation (n = 2), retinal pigment epithelial tear (n = 1) and acute vision loss (n = 1). The systemic complications included cerebral infarction (n = 1), elevation of systolic blood pressure (n = 2), facial skin redness (n = 1), itchy diffuse rash (n = 1) and menstrual irregularities (n = 3). Conclusion: Intravitreal injection of bevacizumab may cause systemic or ocular complications. Caution is advised when considering intravitreal injection of this drug.
  • Sato T, Kusaka S, Oshima Y, Fujikado T.
    Retina. LIPPINCOTT WILLIAMS & WILKINS 28 (5) 749 - 754 0275-004X 2008/05 [Refereed]
     
    Purpose: To investigate the cutting and aspirating properties of eight vitreous cutters under different conditions and to analyze the factors determining these properties. Methods: Commercially available 20-gauge (20-G), 23-G, and 25-G pneumatic vitreous cutters were evaluated. The areas of the inner tube and cutting port were measured with a microscope and 3D-CAD software. The total opening area/s of the cutting port was determined by photographing the movements of the cutter blade with a high-speed camera. The total volume of balanced salt solution aspirated/s was measured. Results: The inner tube areas ranged from 0.350-0.352 mm(2) for the 20-G, 0.169-0.196 mm 2 for the 23-G, and 0.128-0.129 mm(2) for the 25-G cutters. The port areas ranged from 0.254 to 0.306 mm(2) for the 20-G, 0.122 to 0.173 mm(2) for the 23-G, and 0.066 to 0.125 mm 2 for the 25-G cutters. High-speed camera analyses revealed that the total opening area was determined not only by the port area but also by the duty cycle, and that the latter varied among the cutters even under the same cutting speed. There was a positive correlation (R-2 >0.88) between total opening area/s and total aspirated volume/s. Conclusions: Larger cutting port areas and higher duty cycles are associated with higher aspirated volumes of vitreous cutters.
  • Radial Optic Neurotomy for Central Retinal Artery Occlusion
    松田 理, 大下 貴志, 藤井 清美, 内堀 恭孝, 相馬 剛至, 日下 俊次.
    Folia ophthalmologica Japonica 日本眼科紀要会 58 (11) 708 - 711 2007/11 
    Background: We report 3 cases of radial optic neurotomy (RON) for central retinal artery occlusion (CRAO). Case Reports: Three patients (2 males and 1 female) between the ages of 74 and 90 years presented with sudden loss of vision due to CRAO. After conventional treatments, i.e., paracentesis, administration of vasodilator medications, and reduction in intraocular pressure (IOP), had proven ineffective, RON was performed 8 hours to 20 days after the onset of sudden vision loss. RON was performed with 1 to 3 radial cuts at the nasal edge of the optic disc. After RON, none of the patients had improvement in visual acuity. Two patients underwent fluorescein angiography after RON, and retinal circulation was found to be slightly improved in 1 case but not improved in the other, and there was no recovery of visual acuity. Two patients underwent Goldmann visual field perimetry after RON and in both, vision remained only in segmental visual fields. Conclusion: The results in these 3 cases suggest that RON is not effective for CRAO.
  • Fujikado T, Morimoto T, Kanda H, Kusaka S, Nakauchi K, Ozawa M, Matsushita K, Sakaguchi H, Ikuno Y, Kamei M, Tano Y.
    Graefes Arch. Clin. Exp. Ophthalmol. SPRINGER 245 (10) 1411 - 1419 0721-832X 2007/10 [Refereed]
     
    Background To determine the efficient parameters to evoke electrical phosphenes is essential for the development of a retinal prosthesis. We studied the efficient parameters in normal subjects and investigated if suprachoroidal-transretinal stimulation (STS) is effective in patients with advanced retinitis pigmentosa (RP) using these efficient parameters. Methods The amplitude of pupillary reflex (PR) evoked by transcorneal electrical stimulation (TcES) was determined at different frequencies in eight normal subjects. The relationship between localized phosphenes elicited by transscleral electrical stimulation (TsES) and the pulse parameters was also examined in six normal subjects. The phosphenes evoked by STS were examined in two patients with RP with bare light perception. Biphasic pulses (cathodic first, duration: 0.5 or 1.0 ms, frequency: 20 Hz) were applied through selected channel(s). The size and shape of the phosphenes perceived by the patients were recorded. Results The maximum PR was evoked by TcES with a frequency of 20 Hz. The brightest phosphene was elicited by TsES with a pulse train of more than 10 pulses, duration of 0.5-1.0 ms and a frequency of 20 to 50 Hz. In RP patients, localized phosphenes were elicited with a current of 0.3-0.5 mA (0.5 ms) in patient 1 and 0.4 mA (1.0 ms) in patient 2. Two isolated or dumbbell-shaped phosphenes were perceived when the stimulus was delivered through two adjacent channels. Conclusion Biphasic pulse trains (>= 10 pulses) with a duration of 0.5-1.0 ms and a frequency of 20-50 Hz were efficient for evoking phosphenes by localized extraocular stimulation in normal subjects. With these parameters, STS is a feasible method to use with a retinal prosthesis even in advanced stages of RPs.
  • Okawa Y, Fujikado T, Miyoshi T, Sawai H, Kusaka S, Mihashi T, Hirohara Y, Tano Y.
    Invest Ophthalmol Vis Sci. ASSOC RESEARCH VISION OPHTHALMOLOGY INC 48 (10) 4777 - 4784 0146-0404 2007/10 [Refereed]
     
    To determine whether reflectance changes of the retina after electrical suprachoroidal-transretinal stimulation (STS) can be detected with a newly developed optical imaging fundus camera. METHODS. Ten eyes of 10 cats were studied. A small retinal area was focally stimulated with electric currents passing between an active electrode placed in the fenestrated sclera and a reference electrode in the vitreous. Biphasic pulses were applied for 4 seconds with a current up to 500 mu A. Images of the fundus illuminated with near-infrared (800-880 nm) light were obtained every 20 msec for 26 seconds between 2 seconds before and 20 seconds after the STS. Twenty images of 20 consecutive experiments were averaged. A two-dimensional map of the reflectance changes was constructed by subtracting the images before the stimulation from those after the stimulation. STS-evoked potentials (EPs) were recorded from the optic chiasma. RESULTS. Approximately 0.5 second after the onset of STS, reflectance changes were observed around the retinal locus, where the stimulating electrodes were positioned. The intensity of the reflectance changes was correlated with the intensity of the stimulus current. The area of the reflectance change increased as the current intensity increased and was correlated with the amplitude of the EPs (R-2 = 0.82). CONCLUSIONS. Reflectance changes after STS were localized to the area around the electrode. The strong correlation between the area of the reflectance changes and the amplitude of the EPs suggested that the reflectance changes reflected the activity of retinal neurons elicited by electrical stimulation.
  • 眼科学 眼内新生血管に対する抗VEGF治療
    日下 俊次
    医学のあゆみ 医歯薬出版 222 (10) 831 - 832 2007/09
  • Kusaka S, Ikuno Y, Ohguro N, Hori Y, Tano Y.
    Acta Ophthalmol. BLACKWELL PUBLISHING 85 (6) 692 - 693 1395-3907 2007/09 [Refereed]
  • Sayanagi K, Ikuno Y, Soga K, Sawa M, Oshima Y, Kamei M, Kusaka S, Tano Y.
    Br J Ophthalmol. B M J PUBLISHING GROUP 91 (7) 939 - 944 0007-1161 2007/07 [Refereed]
     
    Background: Internal limiting membrane ( ILM) peeling with indocyanine green ( ICG) staining is a commonly used procedure to treat idiopathic macular holes ( MH). Aim: To report changes in the patterns of residual ICG fluorescence over time after vitrectomy using the Heidelberg Retina Angiograph 2 ( HRA2, Heidelberg Engineering, Heidelberg, Germany). Methods: 10 patients ( 10 eyes) who had undergone vitrectomy for MH with ILM peeling were included. 9 ( 90%) patients underwent ILM peeling with ICG, and 1 ( 10%) patient had it with triamcinolone acetonide ( TA). We observed residual ICG using HRA2, postoperatively. Autofluorescence, optical coherence tomography images and best- corrected visual acuity ( BCVA) measurements were also obtained. The minimal follow- up was 3 months. Results: The MHs were closed postoperatively in all patients ( 100%). In eyes that underwent ILM peeling with ICG, the BCVA improved significantly ( p < 0.001) in 8 ( 89%) eyes and was unchanged in 1 ( 11%) eye. HRA2 showed the ICG fluorescence patterns but not TA postoperatively. The ICG hyperfluorescent signal was typically diffuse at the posterior retina and was hypofluorescent around the fovea. The hyperfluorescence then migrated towards the optic nerve disc presumably along the nerve fibre, and the area of ILM peeling was clearly identified. A large number of hyperfluorescent dots were observed instead of diffuse hyperfluorescence that was observed just after surgery. Conclusions: Patterns of residual ICG fluorescence were sequentially observed with HRA2 after vitrectomy for MH with ICG- assisted ILM peeling.
  • Novel mutations in Norrie disease gene in Japanese patients with Norrie disease and familial exudative vitreoretinopathy
    Kondo H, Qin M, Kusaka S, Tahira T, Hasebe H, Hayashi H, Uchio E, Hayashi K.
    Invest Ophthalmol Vis Sci 48 (3) 1276 - 1282 2007/03
  • Nakauchi K, Fujikado T, Kanda H, Kusaka S, Ozawa M, Sakaguchi H, Ikuno Y, Kamei M, Tano Y.
    J Neural Eng. IOP PUBLISHING LTD 4 (1) S50 - S57 1741-2560 2007/03 [Refereed]
     
    The purpose of this study is to determine the threshold suprachoroidal-transretinal stimulation (STS) current that results in retinal damage in rabbits. Biphasic STS pulses (anodic first, frequency 20 Hz) were used to stimulate the retina of pigmented rabbits (n = 18) continuously for 1 h using a 100 mu m diameter platinum wire electrode. The STS current that induced retinal damage after 1 h was determined by ophthalmoscopy or by fluorescein angiography (FA) independently. The effect of the pulse duration on the threshold current was investigated. Histological studies were performed after electrical stimulation experiments. The threshold for a safe current to the retina was 0.6 mA for a duration of 0.5 ms. The threshold for a safe charge increased approximately linearly with an increase of stimulus duration but the threshold for a safe current decreased logarithmically with an increase of duration. The threshold for a safe electrical energy remained almost constant for all durations. Histological examination showed severe retinal damage when the current exceeded the threshold, with more damage in the inner layers compared with the outer layers of the retina. The threshold for the safe current was higher than that reported for direct stimulation of neural tissues, suggesting that the STS method was safe and able to be used with a retinal prosthesis. Because the threshold for the safe charge was lower with shorter pulse durations, care should be taken using pulses of short durations.
  • Sakaguchi H, Ikuno Y, Gomi F, Kamei M, Sawa M, Tsujikawa M, Oshima Y, Kusaka S, Tano Y.
    Br J Ophthalmol. BMJ 91 (2) 161 - 165 0007-1161 2007/02
  • Morimoto T, Fukui T, Matsushita K, Okawa Y, Shimojyo H, Kusaka S, Tano Y, Fujikado T.
    Graefes Arch Clin Exp Ophthalmol. Springer Science and Business Media LLC 244 (10) 1283 - 1292 0721-832X 2006/10
  • Sakaguchi H, Ohji M, Kamei M, Ikuno Y, Fukushima Y, Gomi F, Oshima Y, Kusaka S, Tano Y.
    Retina 26 (5) 555 - 561 0275-004X 2006/05 
    PURPOSE: To assess the efficacy of radial optic neurotomy (RON) for hemicentral retinal vein occlusion (hemi-CRVO) in patients with follow-up of > 12 months. METHODS: Five consecutive patients with hemi-CRVO were enrolled in the study and underwent vitrectomy with RON. The effects of this treatment were assessed by visual acuity, optical coherence tomography, indocyanine green angiography, and kinetic visual field testing. RESULTS: The median and mean visual acuities improved from 20/250 to 20/50 and from 20/286 to 20/51, respectively. Four patients (80%) had visual acuity improvement of ≥3 lines visual acuity in 1 patient (20%) remained the same. Visual acuity in all four eyes with preoperative visual acuity of < 20/200 improved to > 20/200 12 months after surgery. Foveal thickness was gradually reduced during the follow-up period. Chorioretinal anastomosis was detected by indocyanine green angiography in 3 eyes (60%). A temporal visual field defect was found in two eyes. No neovascularization on the iris, angle, optic disk, or retina was detected postoperatively. CONCLUSION: Visual acuity may improve more with RON compared with the natural history of the disease, and no neovascular formation may occur after RON, suggesting that this procedure may be an effective treatment for hemi-CRVO. © The Ophthalmic Communications Society, Inc.
  • Results of Surgery for Pediatric Cataract
    Makino R, Kusaka S, Miura K, Shimojyo H, Hosohata J, Fujikad T, Tano Y.
    Folia ophthalmologica Japonica 日本眼科紀要会 57 (2) 108 - 113 2006/02 
    Purpose: To evaluate the outcome of surgery for pediatric cataract. Methods: The clinical records of 32 children (48 eyes) who had undergone cataract surgery between 1986 and 2005 were reviewed. The ages of the patients at the time of surgery ranged from 1 month to 11 years (mean 3.7 years). The follow-up period ranged from 12 months to 12.6 years (mean 6.1 years). Results: The mean postoperative best-corrected visual acuity (BCVA) of bilaterally pseudophakic patients (1.02) was significantly better than that of unilaterally pseudophakic patients (0.47, p=0.028). With regard to surgical techniques, there was no difference in mean postoperative BCVA or postoperative opacity of the axis of vision between eyes that had undergone anterior vitrectomy and those that had not, or between those in which optic capture had occurred or not. Postoperative iris capture occurred in 2 eyes, in which neither optic capture nor anterior vitrectomy had been performed. Conclusions: The mean postoperative BCVA was significantly better in patients with bilateral cataract than in those with unilateral cataract. Optic capture may be effective for preventing postoperative iris capture.
  • Blau syndromeの母子例
    小豆澤 宏明, 壽 順久, 室田 浩之, 中村 敏明, 伊藤 孝一, 大畑 千佳, 板見 智, 片山 一朗, 日下 俊次, 金澤 伸雄, 河 敬世, 初川 嘉一.
    日本皮膚科学会雑誌 (公社)日本皮膚科学会 115 (13) 2272 - 2275 2005/12 
    我々は,若年発症サルコイドーシスで非常な希な常染色体優性遺伝性疾患であるブラウ症候群(Blau syndrome)の母子例を経験した.ともに両側肺門部リンパ節腫脹(BHL),血清ACE・リゾチームの上昇といった,一般にサルコイドーシスで見られる特徴的所見を欠いていた.本症の家系報告は本邦では2家系目で,皮膚科領域では初めての報告である(著者抄録)
  • KusakaS, Shimojyo H, Oshita T, Fujii K.
    Ophthalmology Elsevier BV 112 (9) 1636 - 1637 0161-6420 2005/09
  • Outcome of vitreous surgery for prematurity of retinopathy with retinal detachment
    Fujii K, Kusaka S, Shimojyo H, Oshita T, Kida T, Iwahashi Y, Harino S, Hatsukawa Y.
    臨床眼科 医学書院 59 (8) 1293 - 1297 2005/08
  • Sawa M, Ohji M, Kusaka S, Sakaguchi H, Gomi F, Saito Y, Tano Y.
    Ophthalmology Elsevier BV 112 (8) 1402 - 1408 0161-6420 2005/08 
    PURPOSE: To report the long-term follow-up results of nonvitrectomizing vitreous surgery for idiopathic epiretinal membrane (ERM). DESIGN: Nonrandomized comparative case series. PARTICIPANTS: Thirty patients were followed up for at least 5 years after nonvitrectomizing vitreous surgery. INTERVENTION: Epiretinal membranes were peeled without infusion of balanced salt solution and removal of the vitreous. The data from the fellow eye was the control data. MAIN OUTCOME MEASURES: We examined the visual acuities (VAs), objective refractions, and slit-lamp and Scheimpflug photographs from the preoperative and the final examinations of both eyes. Quantitative assessment of the progression of nuclear sclerosis was performed by densitometry analysis using Scheimpflug photography. The recurrence rate of ERM was determined. RESULTS: The follow-up periods ranged from 60 to 102 months (mean+/-standard deviation, 72.2+/-11.0 months). The patient ages ranged from 52 to 76 years (68.8+/-6.3 years). The final VA improved or stabilized within 2 lines in 29 of 30 eyes (96.7%). No unilateral progression of nuclear sclerosis occurred in any cases. The mean preoperative and postoperative refractions without additional surgery were -0.4+/-2.9 diopters (D) and -0.2+/-3.0 D in the operated eyes, respectively, and -0.2+/-2.5 D and 0.1+/-2.4 D, respectively, in the unoperated fellow eyes. The mean differences in the refractive error between both eyes (operated eye data minus fellow eye data) were -0.2+/-0.7 D before surgery and -0.3+/-0.8 D after surgery (P = 0.319, paired t test). The mean preoperative and postoperative nuclear densities in 16 patients were 69+/-14 nuclear density units (NDUs) and 76+/-12 NDUs in the operated eyes and 71+/-14 NDUs and 78+/-14 NDUs in the fellow eyes, respectively. The mean preoperative and postoperative differences in nuclear densities in both eyes were -2+/-2 NDUs and -2+/-5 NDUs, respectively (P = 0.836, paired t test). The ERM recurred in 10 eyes (33%), and 3 eyes underwent conventional vitrectomy combined with cataract surgery. CONCLUSIONS: Unilateral nuclear sclerosis did not progress for at least 5 years after nonvitrectomizing vitreous surgery. The recurrence rate of ERM appeared to be higher than that after conventional vitreous surgery.
  • Utilization of Clinical Pathways in the Care of Patients Undergoing Vitreous Surgery
    Oshita T, Kusaka S, Makino R, Fujii K, Tanaka.
    Folia ophthalmologica Japonica 日本眼科紀要会 56 (5) 377 - 341 2005/05
  • Nakata K, Ohji M, Ikuno Y, Kusaka S, Gomi F, Kamei M, Ross DF 3rd, Tano Y.
    Am J Ophthalmol Elsevier BV 137 (4) 760 - 762 0002-9394 2004/04
  • Teba FA, Mohr A, Eckardt C, Wong D, Kusaka S, Joondeph BC, Feron EJ, Stalmans P, Van Overdam K, Melles GR.
    Ophthalmology . Elsevier BV 110 (12) 2409 - 2412 0161-6420 2003/12
  • Kusaka S, Oshita T, Ohji M, Tano Y.
    RETINA Ovid Technologies (Wolters Kluwer Health) 23 (5) 733 - 734 0275-004X 2003/10
  • Ikuno Y, Sayanagi K, Oshima T, Gomi F, Kusaka S, Kamei M, Ohji M, Fujikado T, Tano Y.
    Am J Ophthalmol. Elsevier BV 136 (3) 477 - 481 0002-9394 2003/09
  • Ishii M, Fujita A, Iwai K, Kusaka S, Higashi K, Inanobe A, Hibino H, Kurachi Y.
    Am J Physiol Cell Physiol. American Physiological Society 285 (2) C260 - C267 0363-6143 2003/08 
    Kir5.1 is an inwardly rectifying K+channel subunit whose functional role has not been fully elucidated. Expression and distribution of Kir5.1 in retina were examined with a specific polyclonal antibody. Kir5.1 immunoreactivity was detected in glial Müller cells and in some retinal neurons. In the Kir5.1-positive neurons the expression of glutamic acid decarboxylase (GAD65) was detected, suggesting that they may be GABAergic-amacrine cells. In Müller cells, spots of Kir5.1 immunoreactivity distributed diffusely at the cell body and in the distal portions, where Kir4.1 immunoreactivity largely overlapped. In addition, Kir4.1 immunoreactivity without Kir5.1 was strongly concentrated at the endfoot of Müller cells facing the vitreous surface or in the processes surrounding vessels. The immunoprecipitant obtained from retina with anti-Kir4.1 antibody contained Kir5.1. These results suggest that heterotetrameric Kir4.1/Kir5.1 channels may exist in the cell body and distal portion of Müller cells, whereas homomeric Kir4.1 channels are clustered in the endfeet and surrounding vessels. It is possible that homomeric Kir4.1 and heteromeric Kir4.1/Kir5.1 channels play different functional roles in the K+-buffering action of Müller cells.
  • Nakata K, Ohji M, Ikuno Y, Kusaka S, Gomi F, Tano Y.
    Graefes Arch Clin Exp Ophthalmol. Springer Science and Business Media LLC 241 (7) 582 - 584 0721-832X 2003/07
  • Changes in the Last Decade in Vitrectomy for Diabetic Retinopathy
    Oie Y, Nakata K, Sakaguchi H, Ikuno Y, Gomi F, Kusaka S, Ohji M, Tano Y, Kusunoki T, Hasegawa T, Danjo Y.
    Folia ophthalmologica Japonica 日本眼科紀要会 54 (5) 339 - 343 2003/05 
    Purpose: We evaluated changes over the last decade in indications for vitrectomy for diabetic retinopathy. Methods: We compared indications for initial vitrectomy to treat tractional retinal detachment (TRD), vitreous hemorrhage (VH), or macular edema (ME) in 3 groups of eyes: 169 eyes treated in 1991 and 1992 (group A), 246 eyes treated between 1994 and 1995 (group B), and 208 eyes treated between 1999 and 2000 (group C). Results: Group A included 117 eyes with TRD (69%), 48 eyes with VH (28%), and 3 eyes with ME (2%). TRD was the indication for vitrectomy in 121 eyes (49%), VH was the indication in 90 eyes (37%), and ME was the indication in 31 eyes (13%) in group B, whereas TRD was the indication for vitrectomy in 60 eyes (29%), VH was the indication in 77 eyes (37%), and ME was the indication in 67 eyes (32%) in group C. Conclusion: TRD decreased as an indication for vitrectomy, probably because of improved management of diabetes mellitus and diabetic retinopathy, and ME increased because it is a new indication for vitrectomy.
  • Kusaka S, Hayashi N, Ohji M, Ikuno Y, Gomi F, Tano Y
    Arch Ophthalmol. American Medical Association (AMA) 121 (5) 732 - 732 0003-9950 2003/05
  • Cekiç O, Ohji M, Zheng Y, Hayashi A, Kusaka S, Tano Y.
    Am J Ophthalmol. Elsevier BV 135 (5) 641 - 647 0002-9394 2003/05
  • Zheng Y, Ikuno Y, Ohj M, Kusaka S, Jiang R, Cekiç O, Sawa M, Tano Y.
    Jpn J Ophthalmol. Elsevier BV 47 (2) 158 - 165 0021-5155 2003/04
  • Sou R, Kusaka S, Ohji M, Gomi F, Ikuno Y, Tano Y.
    Am J Ophthalmol. Elsevier BV 135 (4) 537 - 539 0002-9394 2003/04
  • Otori Y, Kusaka S, Kawasaki A, Morimura H, Miki A, Tano Y.
    Brain Res . Elsevier BV 961 (2) 213 - 219 0006-8993 2003/01
  • Fujikado T, Asonuma S, Ohji M, Kusaka S, Hayashi A, Ikuno Y, Kamei M, Oda K, Tano Y.
    Am J Ophthalmol Elsevier BV 134 (6) 849 - 856 0002-9394 2002/12
  • Apparent disappearance of choroidal neovascularization after initial photodynamic therapy with verteporfin
    Sawa M, Ohji M, Gomi F, Kusaka S, Tano Y, Bressler NM.
    Arch Ophthalmol . 120 (11) 1588 - 1590 2002/11
  • Inoue Y, Yamamoto S, Inoue T, Fujikado T, Kusaka S, Ohguro N, Ohji M, Tano Y.
    Am J Ophthalmol. Elsevier BV 134 (4) 622 - 624 0002-9394 2002/10
  • Cekiç O, Ohji M, Hayashi A, Fang XY, Kusaka S, Tano Y.
    Am J Ophthalmol. Elsevier BV 134 (1) 75 - 80 0002-9394 2002/07
  • Ikuno Y, Ohji M, Kusaka S, Gomi F, Nakata K, Futamura H, Tano Y.
    Am J Ophthalmol. Elsevier BV 133 (6) 847 - 848 0002-9394 2002/06
  • Ohji M, Fujikado T, Kusaka S, Hayashi A, Hosohata J, Ikuno Y, Sawa M, Kubota A, Hashida N, Tano Y.
    Am J Ophthalmol Case Rep. ELSEVIER SCIENCE INC 132 (6) 888 - 896 0002-9394 2001/12 
    - PURPOSE: To report the results of three methods of foveal translocation in the presence of subfoveal choroidal neovascular membrane resulting from age related macular degeneration. - METHODS: We treated 51 eyes of 51 consecutive patients with subfoveal choroidal neovascular membranes resulting from age-related macular degeneration with one of three techniques of foveal translocation surgery: foveal translocation with partial retinotomy (n = 6), limited translocation (n = 9), and translocation with 360-degree retinotomy (n = 36). All patients were followed for at least 6 months postoperatively. The size of the choroidal neovascular membrane and the amount of foveal displacement, the best,corrected visual acuity, and complications were recorded preoperatively and posts operatively. - RESULTS: The mean distance of the foveal translocation was greater in the 360,degree retinotomy group (3340 mum) than in the partial retinotomy (1060 mum, P < .001) and the limited translocation groups (1120 mum, P < .001). A final visual acuity of 20/200 or better was achieved in two eyes (33%) in the partial retinotomy group, seven eyes (78%) in the limited translocation group, and 23 eyes (64%) in the 360,degree retinotomy group. The final visual acuity improved by 0.2 logarithm of minimal angle of resolution (logMAR) unit or more in one eye (17%), one eye (11%), and seven eyes (19%), respectively. The final visual acuity was maintained within I line in zero eyes, five eyes (56%), and 19 eyes (53%), respectively. A retinal detachment developed postoperatively in five eyes (83%), zero eyes (0%), and 15 eyes (42%), respectively. - CONCLUSIONS: A significant number of patients improved or maintained best corrected visual acuity after translocation with 360-degree retinotomy, and limited translocation, whereas translocation with 360 degree retinotomy is suitable for larger choroidal neovascular membranes because it resulted in the greatest foveal displacement among the three translocation procedures. (C) 2001 by Elsevier Science Inc. All rights reserved.
  • 日下 俊次
    Folia ophthalmologica Japonica 52 (10) 899 - 890 0015-5667 2001/10
  • Kubota A, Ohji M, Kusaka S, Hayashi A, Hosohata J, Fujikado T, Tano Y.
    Am J Ophthalmol . Elsevier BV 132 (4) 581 - 584 0002-9394 2001/10
  • Sawa M, Saito Y, Hayashi A, Kusaka S, Ohji M, Tano Y.
    Am J Ophthalmol. Elsevier BV 132 (3) 356 - 362 0002-9394 2001/09
  • Oshita T, Hayashi S, Inoue T, Hayashi A, Maeda N, Kusaka S, Ohji M, Fujikado T, Tano Y.
    Graefes Arch Clin Exp Ophthalmol. Springer Science and Business Media LLC 239 (5) 382 - 386 0721-832X 2001/06
  • Ohji M, Futamura H, Sanger D, Nakata K, Hayashi A, Kusaka S, Tano Y.
    Jpn J Ophthalmol. Elsevier BV 45 (2) 199 - 201 0021-5155 2001/04
  • Fang XY, Hayashi A, Cekic O, Morimoto T, Ohji M, Kusaka S, Kamei M, Fujikado T, Tano Y.
    Am J Ophthalmol . Elsevier BV 131 (4) 481 - 488 0002-9394 2001/04
  • Kusaka S, Hayashi N, Ohji M, Hayashi A, Kamei M, Tano Y.
    Am J Ophthalmol. Elsevier BV 131 (3) 388 - 390 0002-9394 2001/03
  • Kusaka S, Inanobe A, Fujita A, Makino Y, Tanemoto M, Matsushita K, Tano Y, Kurachi Y.
    J Physiol. Wiley 531 (1) 27 - 36 0022-3751 2001/02
  • Kusaka S, Saito Y, Okada AA, Sasamoto M, Hayashi A, Ohji M, Tano Y.
    Ophthalmologica S. Karger AG 215 (2) 139 - 141 0030-3755 2001
  • Fujikado T, Ohji M, Kusaka S, Hayashi A, Kamei M, Okada AA, Oda K, Tano Y.
    Am J Ophthalmol . ELSEVIER SCIENCE INC 131 (1) 101 - 110 0002-9394 2001/01 
    PURPOSE: To assess functional and anatomical outcomes after foveal translocation with 360-degree retinotomy and simultaneous torsional muscle surgery in patients with myopic neovascular maculopathy. METHODS: Foveal translocation with 360-degree retinotomy was performed in 11 eyes of 11 patients with myopic neovascular maculopathy. Ten eyes had simultaneous torsional muscle surgery with recession of the superior oblique muscle and tucking of the inferior oblique muscle. Silicone oil removal with or without intraocular lens implantation was performed 2 to 8 weeks after the primary procedure. Visual acuity, binocular function, and degree of cyclotorsion were assessed preoperatively and postoperatively. Angles of retinal and globe rotation, distance of foveal shift, and surgical complications were also investigated. RESULTS: With a mean postoperative follow-up of 6.2 months (range, 3 to 13 months), vision improved (greater than 0.2 logarithm of minimal angle of resolution [logMAR] units) in eight eyes, was unchanged in two eyes, and worsened (greater than 0,2 logMAR units) in 1 eye. Seven of 11 eyes (64%) had a final visual acuity of 20/50 or better. Five patients developed or maintained binocular fusion, four patients continued to have suppression, and two patients developed diplopia that was managed by spectacles with Fresnel prisms. Subjective cyclotorsion was less than 8 degrees in 10 eyes. Mean retinal and globe rotations were 23.4 degrees and 19.8 degrees, respectively. Average size of the choroidal neovascular membrane was 0.8 disk diameter, whereas the average distance of foveal shift was 1.5 disk diameter. After the primary procedure, three eyes developed retinal detachment, one eye macular hole, and one eye proliferative vitreoretinopathy. These complications were successfully managed by additional surgery. CONCLUSION: Foveal translocation with 360-degree retinotomy is effective in restoring vision in some patients with myopic neovascular maculopathy. Although the development of torsional diplopia is generally obviated by simultaneous extraocular muscle surgery, a relatively high incidence of surgical complications should be taken into account with this procedure. (Am J Ophthalmol 2001;131:101-110, (C) 2001 by Elsevier Science Inc. All rights reserved.).
  • Retinal changes after retinal translocation surgery with scleral imbrication in dog eyes
    Hayashi A, Usui S, Kawaguchi K, Fujioka S, Kusaka S, Fujikado T, Ohji M, Tano Y.
    Invest Ophthalmol Vis Sci. Association for Research in VisionandOphthalmology 41 (13) 4288 - 4292 2000/12
  • Cekic O, Ohji M, Fujikado T, Fang XY, Hayashi A, Kusaka S, Tano Y.
    Ophthalmology. Elsevier BV 107 (12) 2117 - 2117 0161-6420 2000/12
  • 日下 俊次
    Folia ophthalmologica Japonica 51 (11) 1083 - 1084 0015-5667 2000/11
  • Bilateral giant macular hole
    Kusaka S, Hosotani H, Hayashi A, Ohji M, Fujikado T, Tano Y.
    Arch Ophthalmol American Medical Association 118 (10) 1453 - 1455 2000/10
  • Sakaguchi H, Ohji M, Kubota A, Otori Y, Hayashi A, Kusaka S, Saito Y, Tano Y.
    Am J Ophthalmol. Elsevier Inc. 130 (3) 355 - 356 0002-9394 2000/09 
    PURPOSE: To compare a macular hole from accidental Nd:YAG laser injury with idiopathic macular holes. METHODS: Case report. In a 24-year-old man with accidental Nd:YAG laser injury, right eye, Amsler grid testing and optical coherence tomography were performed. RESULTS: Nd:YAG laser injury was responsible for a macular hole about 700 μm in diameter. The visual acuity was 20/100. Amsler grid testing displayed a central scotoma with no surrounding distortion. Optical coherence tomography showed a defect in all retinal layers at the macula. CONCLUSION: The scotoma caused by Nd:YAG laser injury is not surrounded by distortion the hole is produced by the defect of all retinal layers. In contrast, idiopathic macular holes generally produce a pincushion pattern on Amsler grid testing and have no tissue loss. (C) 2000 by Elsevier Science Inc.
  • Kusaka S, Okada AA, Hayashi A, Higaki S, Ohji M, Tano Y.
    Retina Ovid Technologies (Wolters Kluwer Health) 20 (4) 417 - 418 0275-004X 2000/04
  • Inoue Y, Yamamoto S, Okada M, Tsujikawa M, Inoue T, Okada AA, Kusaka S, Saito Y, Wakabayashi K, Miyake Y, Fujikado T, Tano Y.
    Arch Ophthalmol . AMER MEDICAL ASSOC 118 (1) 93 - 96 0003-9950 2000/01 
    Background: X-linked retinoschisis (XLRS) is a relatively rare vitreoretinal dystrophy that causes visual loss in young men. Recently, a gene responsible for this disease, designated XLRS1, was identified, and several deleterious gene mutations were reported. Objective: To analyze Japanese patients clinically diagnosed as having XLRS formutational changes in the XLRS1 gene. Methods: Ten patients with XLRS underwent full ophthalmologic examination, including slitlamp biomicroscopy and dilated funduscopy. Genomic DNA was isolated from leukocytes, and all exons of the XLRS1 gene were amplified by polymerase chain reaction and analyzed using a direct sequencing method. Results: Point mutations in the XLRS1 gene were identified in all 10 patients. The mutations were identical in each of 2 pairs of brothers. Six of the point mutations represented missense mutations, 1 was a nonsense mutation, and 1 was a frameshift mutation. Five of the mutations are newly reported herein. Conclusions: The discovery of new point mutations in this study increases the available information regarding the spectrum of genetic abnormalities and clinical manifestations of XLRS. However, the limited data failed to reveal a correlation between mutation and disease phenotype. Clinical Relevance: Identification of mutations in the XLRS1 gene and expanded information on clinical manifestations will facilitate early diagnosis, appropriate early therapy, and genetic counseling regarding the prognosis of XLRS.
  • Mikajiri K, Okada AA, Ohji M, Morimoto T, Sato S, Hayashi A, Kusaka S, Saito Y, Tano Y.
    Am J Ophthalmol. ELSEVIER SCIENCE INC 128 (5) 655 - 657 0002-9394 1999/11 
    PURPOSE: To evaluate foveal structure after vitrectomy for idiopathic macular hole in relation to postoperative visual outcome. METHODS: Optical coherence tomography was performed postoperatively to assess retinal thickness at the foveal center in patients who underwent vitrectomy, posterior hyaloid membrane removal, and perfluoropropane gas tamponade for idiopathic macular hole. Thirty-seven eyes of 36 patients documented to have achieved anatomic hole closure by optical coherence tomography were included in the study. RESULTS: Increased visual acuity significantly correlated with greater foveal thickness assessed at a median of 5 months postoperatively (Spearman analysis; R = .453, P = .005). CONCLUSION: Visual outcome after anatomic closure of macular holes by vitrectomy is closely related to the structure of the center of the fovea postoperatively. (C) 1999 by Elsevier Science Inc. All rights reserved.
  • Kusaka S, Horio Y, Fujita A, Matsushita K, Inanobe A, Gotow T, Uchiyama Y, Tano Y, Kurachi Y.
    J Physiol. CAMBRIDGE UNIV PRESS 520 (2) 373 - 381 0022-3751 1999/10 
    1. In the eye, different substances and ions including potassium (K+) are transported between neural retina and choroid via the subretinal space. Inwardly rectifying K+ channels (Kir) on the apical membrane of retinal pigment epithelial (RPE) cells are thought to play an essential role in K+ transport in the subretinal space. 2. Single-channel recordings from the apical membrane of RPE cells exhibited functional expression of a Kir channel with properties identical to those of Kir4.1, while recordings from the basolateral membrane showed no detectable Kir channel currents. 3. The expression of Kir4.1 mRNA in RPE cells was confirmed by RT-PCR analysis and in situ hybridization, Furthermore, using immunohistochemistry, we found that Kir4.1 was prominently expressed in RPE cells and localized specifically on the processes on their apical membrane. 4. Developmental studies revealed that expression of Kir4.1 started to appear 10 days Or later after birth in RPE cells, in parallel with the maturation of retinal neuronal activity as represented by the a- and b-waves of the electroretinogram. 5. These data suggest that Kir4.1 is one of the Kir channels involved in RPE-mediated control of K+ ions in the subretinal space.
  • A VIEW FOR THE TELE-MEDICAL SUPPORT OF THE MENTAL-HEALTHCARE FOR JAPANESE OVERSEAS
    Ueda T, Takeda N, Kusaka S, Mizoo A, Makino E, Nakada S, Sugimoto H.
    The journal of Japan Accident Medical Association (一社)日本職業・災害医学会 47 (10) 637 - 641 1999/10
  • Risk factors for vitreous hemorrhage following vitrectomy in diabetic retinopathy
    Kusaka S, Imai T, Sakagami K, K Chang, Maeda N, Fujikado H, Ikeda T, Haruta Y, Tano Y.
    Folia Ophthalmologica Japonica 日本眼科紀要会 41 (9) 1793 - 1798 1999/09
  • 森本 壮, 林 篤志, 日下 俊次, 大路 正人, 斉藤 喜博, 岡田 アナベル, 田野 保雄.
    臨床眼科 (株)医学書院 53 959 - 962 1999/05
  • Kusaka S, Kapousta-Bruneau NV, Puro DG
    Glia Wiley 25 (3) 205 - 215 0894-1491 1999/02
  • Optical coherence tomography of the involved macula after retinal detachment surgery
    Morimoto T, Hayashi A, Kusaka S, Ohji M, Saito Y, Okada A. A , Tano Y.
    Jpn J Ophthalmol. 医学書院 53 959 - 962 1999/01 [Refereed]
     
    We performed optical coherence tomography (OCT) in 13 eyes of rhegmatogenous retinal detachment involving the macula. In 10 eyes which showed foveal reflex after surgery, the foveal depression was reformed also. In the other 3 eyes which failed to show foveal reflex by biomicroscopy, OCT showed residual subretinal fluid in 2 eyes and retinal pigment epithelial detachment in 1. The thickness of the central fovea as assessed by OCT was not correlated with the best-corrected visual acuity after surgery.
  • Fujikado T, Ohji M, Hayashi A, Kusaka S, Tano Y.
    Am J Ophthalmol. Elsevier Inc. 126 (6) 839 - 842 0002-9394 1998/12 
    PURPOSE: To document the anatomic and functional recovery of the fovea after foveal translocation surgery with scleral shortening and simultaneous excision of a neovascular membrane in a patient with age-related macular degeneration. METHOD: Case report. RESULTS: The visual acuity of a 54-year- old woman with age-related macular degeneration improved from 20/200 to 20/50 after excision of subretinal neovascular membrane and foveal translocation surgery in the right eye. Fixation shifted inferonasally 0.6 disk diameters, corresponding to the direction of foveal translocation, as shown by scanning laser ophthalmoscope microperimetry. Postoperative optical coherence tomography through fixation disclosed normal foveal concavity and intact retinal pigment epithelium. CONCLUSION: Anatomic and functional recovery of the fovea was confirmed in a patient with age-related macular degeneration after foveal translocation surgery with scleral shortening and simultaneous excision of a neovascular membrane.
  • Tangential vitreous traction observed in optic disc pit maculopathy without apparent serous detachment
    Joko T, Kusaka S.
    Ophthalmic Surg Lasers. 29 (8) 677 - 679 1998/08
  • Joko T, Kusaka S.
    Ophthalmic Surg Lasers. SLACK INC 29 (8) 677 - 679 0022-023X 1998/08 [Refereed]
     
    The authors describe a rare case of a patient with an optic pit that was accompanied by a cyst-like change in the macula without serous retinal detachment. A 38-year-old woman with a 10-year history of visual impairment in her right eye was referred to the authors' clinic. The best-corrected visual acuity was 20/200 in the right eye, and ophthalmoscopy showed a cyst-like change in the macula with tangential traction by the surrounding vitreous, The patient was treated with vitrectomy and the posterior vitreous was separated from the retina during the procedure. After the surgery, the cyst-like region disappeared and the corrected visual acuity improved to 20/40. The authors suggest that tangential vitreous traction played an important role in the pathogenesis of the optic pit maculopathy.
  • Kusaka S, Toshino A, Ohashi Y, Sakaue E.
    Jpn J Ophthalmol. Elsevier BV 42 (3) 218 - 222 0021-5155 1998/05
  • Kusaka S, Kapousta-Bruneau N, Green DG, Puro DG.
    J Physiol. Wiley 506 (2) 445 - 458 0022-3751 1998/01
  • Long-term visual recovery after scleral buckling of macula-off retinal detachments
    ToshinoA, Kusaka S, Ohashi Y, Sakaue E.
    Jpn J Ophthalmol. (公財)日本眼科学会 101 (11) 862 - 865 1997/11 
    We retrospectively investigated long-term visual recovery in 32 macular reattached eyes which had been followed up for more than five years after surgery. In 17 eyes (53%), the best-corrected visual acuity at 5 years after surgery was ≤2 lines better than best-corrected visual acuity at 3 months postoperatively. For these 17 eyes, the mean visual acuity continued to improve for up to 10 years after surgery. In the other 15 eyes, visual acuity changes were within 1 line. Improvement of long-term postoperative visual acuity was found to be statistically correlated with younger age, no or mild myopia (< - 5D) and shorter duration of macular detachment (≤30 days). Surgeons should be aware that the visual function of reattached retinas may recover in the long-term, especially in eyes with these features.
  • Kusaka S, Sakagami K, Kutsuna M, Ohashi Y.
    Jpn J Ophthalmol. Elsevier BV 41 (5) 332 - 338 0021-5155 1997/09
  • Results of Vitrectomy for Diffuse Macular Edema Associated with Diabetic Retinopathy
    Joko T, Kusaka S, Sakagami K, Hosokawa M, Ohashi Y.
    Folia ophthalmologica Japonica 日本眼科紀要会 48 (7) 922 - 926 1997/07 
    We performed pars plana vitrectomy to treat diffuse diabetic macular edema in 12 eyes of 7 patients. Patients ranged in age from 47 to 72 (mean±SD=61.9±9.3) years and were followed for between 8 and 29 (18.0±6.6) months after surgery. Preoperatively, posterior vitreous detachment was considered to be absent in 9 eyes and present in 3 eyes because of the presence of Weiss' ring. Macular edema resolved postoperatively in all eyes and fluorescein leakage disappeared in 10 eyes and decreased in 2 eyes. At the last postoperative follow-up visit, visual acuity had improved by 2 lines or more in 5 eyes (42%) and was unchanged in 7 eyes (58%). Improved visual acuity was associated with relatively short duration of macular edema. These results indicate that pars plana vitrectomy is beneficial for the treatment of diffuse diabetic macular edema.
  • Indocyanine green dye enhanced diode laser transscleral retinal photocoagulation in albino rabbits
    Kusaka S, Nakae K, Danjo Y, Tano Y, Ishii Y.
    Folia Ophthalmologica Japonica 日本眼科紀要会 48 (5) 648 - 652 1997/07 
    We conducted a study to determine whether diode laser transscleral photocoagulation could produce retinal burns in nonpigmented eyes with the use of indocyanine green (ICG). Approximately 2 to 5 minutes after intravenous injection of 5, 10, or 15 mg/kg ICG in 9 albino rabbits, laser transscleral photocoagulation was performed in 1 eye of each rabbit. The power and burn duration were kept constant at 1 W and 0.5 second, respectively. Fundus examinations were performed 1 hour, 1 week, and 1 month after photocoagulation, after which the rabbits were killed and their eyes were examined histologically. Higher doses of ICG correlated with larger retinal burns, greater occlusion of choriocapillaris and choroidal vessels, and more severe damage to the outer retina. The results of our study suggest the possible clinical application of ICG enhanced diode laser transscleral photocoagulation in poorly or nonpigmented eyes.
  • 愛媛大学における硝子体手術成績
    清家 千鶴子, 日下 俊次, 坂上 憲史, 石川 明邦
    あたらしい眼科 (株)メディカル葵出版 14 (6) 933 - 937 1997/06
  • Kusaka S, Fujikado T, Ikeda T, Tano Y.
    Am J Ophthalmol. Elsevier BV 123 (6) 837 - 839 0002-9394 1997/06
  • 自己血清を用いた全層黄斑円孔に対する硝子体手術成績
    忽那 実紀, 日下 俊次, 坂上 憲史, 大橋 裕一
    日本眼科學会雜誌 日本眼科学会 101 (5) 407 - 412 1997/05
  • Kusaka S, Puro DG.
    J Physiol Wiley 500 (3) 593 - 604 0022-3751 1997/05
  • Seike C, Kusaka S, Sakagami K, Ohashi Y.
    Retina. Ovid Technologies (Wolters Kluwer Health) 17 (1) 2 - 6 0275-004X 1997
  • Kusaka S, Dabin I, Barnstable CJ, Puro DG.
    J Physiol. Wiley 497 (3) 813 - 824 0022-3751 1996/12
  • Kusaka S, Kodama T, Ohashi Y.
    Am J Ophthalmol. Elsevier BV 121 (5) 574 - 575 0002-9394 1996/05
  • Transient myopia after pars plana vitrectomy
    Kusaka S, Mano T, Ohashi Y.
    Ophthalmic Surg Lasers SlackIncorporated 27 (1) 75 - 76 1996/01
  • Kusaka S, Ohashi Y.
    RETINA Ovid Technologies (Wolters Kluwer Health) 16 (4) 312 - 316 0275-004X 1996
  • Kusaka S, Mano T, Ohashi Y.
    Ophthalmic Surg Lasers. SLACK INC 27 (1) 75 - 76 0022-023X 1996/01 [Refereed]
  • Three Cases of Endogenous Bacterial Endophthalmitis Due to Klebsiella Pneumoniae
    Ishikawa H, Kusaka S, Haruta Y, Ohashi Y, Takubo K, Sanada Y.
    Folia ophthalmologica Japonica 日本眼科紀要会 46 (7) 761 - 766 1995/07
  • A case of Valsalva hemorrhagic retinopathy
    Kusaka S, Joko T, Haruta Y, Ohashi Y, Funasaka K.
    Japanese Journal of Clinical Ophthalmology 医学書院 49 (3) 513 - 515 1995/03
  • Use of the Panoramic Viewing System(R) in Vitreous Surgery
    Hayashi H, Kusaka S, Ohashi Y, Tano Y.
    J Ophthalmol 日本眼科手術学会誌 8 (1) 117 - 120 1995/01
  • Kusaka S, Tsujioka M, Mano T, Tsuboi S, Ohashi Y.
    Am J Ophthalmol . Elsevier BV 117 (4) 533 - 534 0002-9394 1994/04
  • Rapid growth of eyelid squamous cell carcinoma in elderly patients with multiple cancers
    Kusaka S, Sasabe T, Yamamoto S, Sekimoto M, Okuda H, Fujikawa M.
    Nippon Ganka Gakkai Zasshi 日本眼科学会 98 (2) 206 - 211 1994/02
  • 眼内レンズ挿入術前後の瞳孔径の変化
    日下 俊次, 高木 敬之, 辻岡 雅典, 小島 伸介, 真野 富也, 坪井 俊児
    Japanese Journal of Clinical Ophthalmology 医学書院 47 (6) 1313 - 1316 1993/06 
    眼内レンズ挿入術前後の症例44例58眼につき,術前,術後1か月,術後3か月に暗所での瞳孔径,および0.5%トロピカミドと0.5%塩酸フェニレフリン混合液(ミドリンP®)点眼後の瞳孔径を測定した。暗所での瞳孔径,ミドリンP®の点眼後の瞳孔径ともに術前に比し,術後1か月では有意に小さく,術後3か月では有意な差がなかった。術後3か月の暗所での瞳孔径と術前の暗所での瞳孔径との相関の方が,術後3か月の暗所での瞳孔径と術前のミドリンP®点眼後の瞳孔径との相関よりも強く,術後の暗所での瞳孔径を推定する手段として術前の暗所での瞳孔径を測定する方法が優れていると考えられた。術前に暗所での瞳孔径を測定する方法は,白内障手術予定の患者に適切な光学径の眼内レンズを選択する際に有用であると考えられた。
  • Vitreous surgery for epiretinal membranes
    Kusaka S, Kusunoki T, Danjo Y, Ikeda T, Tano Y.
    Japanese Journal of Clinical Ophthalmology 医学書院 46 (2) 123 - 127 1992/02
  • Pars plana vitrectomy for ocular toxocariasis
    Sakagami K, Tano Y, Haruta Y, Ikeda T, Fujikado H, Nakae K, K. Chang, Kusaka S, Imai T, Tsuji M.
    Japanese Journal of Clinical Ophthalmology 医学書院 45 (10) 1647 - 1650 1991/10
  • Rubeosis iridis following diabetic vitrectomy
    K. C. Chang, Tano Y, Fujikado T, Maeda N, Ikeda T, Haruta Y, Kusaka S, Sakagami K, Imai T.
    K. C. Chang, Tano Y, Fujikado T, Maeda N, Ikeda T, Haruta Y, Kusaka S, Sakagami K, Imai T. 日本眼科紀要会 42 (5) 1064 - 1067 1991/05
  • Seven cases of diabetic keratoepitheliopathy successfully treated by anterior stromal puncture
    Hosotani H, Tano Y, Ikeda T, Kusaka S, Ikushima M, Nakae K, Manabe R.
    Folia Ophthalmologica Japonica 日本眼科紀要会 42 841 - 845 1991/05
  • Nine cases of inclusion conjunctivitis
    Kusaka S, Maeda N, Ohashi Y.
    Folia Ophthalmologica Japonica 日本眼科紀要会 42 (5-1) 732 - 737 1991/05
  • Vitrectomy for macular heterotopia associated with proliferative diabetic retinopathy
    Kusaka S, Ikeda T, Tano Y.
    Japanese Journal of Clinical Ophthalmology 医学書院 45 (2) 165 - 169 1991/02
  • 糖尿病黄斑偏位に対する硝子体手術
    日下 俊次, 池田 恒彦, 田野 保雄
    臨床眼科 (株)医学書院 45 (2) 96 - 97 1991/02
  • Overnight absolute bed rest for postoperative vitreous hemorrhage
    Sakagami K, Tano Y, Haruta Y, Ikeda T, Fujikado T, Maeda N, K. C. Chang, Kusaka S, Imai T.
    Folia Ophthalmologica Japonica 日本眼科紀要会 42 1051 - 1054 1991/01
  • 日下 俊次, 今居 寅男, 春日 恭照
    眼科臨床医報 眼科臨床医報会 84 (10) 2145 - 2148 1990/10
  • 増殖糖尿病網膜症に対する硝子体手術 術後硝子体出血をきたす要因について
    日下 俊次, 今居 寅男, 坂上 憲史
    日本眼科紀要 日本眼科紀要会 41 (9) 1793 - 1798 1990/09
  • Treatment of fibrovascular membrane under hyperinfusion pressure during vitrectomy for proliferative diabetic retinopathy
    Ikushima M, Tano Y, Ikeda T, Nakae R, H K, Nakae R, Kusaka S, Sato Y.
    Japanese Journal of Clinical Ophthalmology (株)医学書院 44 (8) 1311 - 1315 1990/08 
    活動性の高い線維血管性増殖組織を伴う糖尿病性黄斑部牽引性網膜剥離16例17眼に対し,硝子体手術中,超高灌流圧下で一時的に網膜中心動脈を途絶させた状態にして増殖膜の処理を行った。この間ほぼ完全な術中止血が得られ,超高灌流圧は82mmHgから105mmHgで,その持続時間は0.9分から最高16.5分(平均4.1分)に及んだ。その結果,16眼(94%)に網膜復位が得られ,15眼(88%)に視力改善が認められたが視力悪化例はなかった。 超高灌流圧下での増殖膜処理は良好な視認性により術中合併症を防止し,手術時間を短縮するとともに手術成績も向上させた。また,増殖糖尿病網膜症でも10分間以上の虚血に耐えると考えられた。
  • Vitreo-retinal surgery in patients with juvenile retinal detachment
    Ikeda T, Tano Y, Haruta Y, Fujikado T, Maeda N, Kusaka S, K C Chang, Imai T, Sakagami K.
    Folia Ophthalmologica Japonica 日本眼科紀要会 41 (4) 668 - 672 1990/04
  • Retinal detachment in morning glory syndrome
    Nakae K, Kusaka S, Ikushima M, Hosotani H, Ikeda T, Tano Y.
    Japanese Journal of Clinical Ophthalmology 医学書院 43 (11) 1677 - 1682 1989/10
  • Treatment of postsurgical proliferative vitreoretinopathy with anterior loop traction
    Ikeda T, Tano Y, Hosotani H, Nakae K, Ikushima M, Kusaka S.
    Japanese Journal of Clinical Ophthalmology 医学書院 43 (9) 1407 - 1410 1989/09
  • Sympathetic ophthalmia with three cases of choroidal detachment after pars plana vitrectomy
    Ikeda T, Chu KC, Imai T, Sakagami K, Kusaka S, Nakae K, Fujikado T, Haruta Y, Tano Y, Hohki T.
    Folia Ophthalmologica Japonica 日本眼科紀要会 40 (6) 1258 - 1263 1989/06
  • Cataract induced by intravitreal gas
    Ikeda T, Tano Y, Hosotani H, Nakae K, Ikushima M, Kusaka S.
    Japanese Journal of Clinical Ophthalmology 医学書院 43 (6) 956 - 959 1989/06
  • Inferior semicircular retinotomy for residual retinal detachment
    Nakae K, Kusaka S, Ikusima M, Hosotani H, Ikeda T, Tano Y.
    臨床眼科 医学書院 42 (12) 1367 - 1371 1988/12
  • 池田 恒彦, 田野 保雄, 細谷 比佐志, 中江 一人, 生島 操, 日下 俊次
    Ikeda T, Tano Y, Hosotani H, Nakae K, Ikushima M, Kusaka S.
    Japanese Journal of Clinical Ophthalmology 医学書院 42 (9) 1075 - 1077 1988/09
  • Fibrovascular proliferation in the fundus periphery in ocular parasitosis
    Ikeda T, Tano Y, Hosotani H, Tamada R, Nakae K, Ikushima M, Kusaka S, Tsuji M.
    Japanese Journal of Clinical Ophthalmology 医学書院 42 (7) 787 - 792 1988/07

MISC

  • Current Status and Issues of Treatment for Retinopathy of Prematurity
    Kusaka S  Journal of Japznese Ophthalmological Society  128-  (5)  389  -391  2024/05
  • 特集(1)小児の網膜硝子体手術 小児眼内注入留置物質
    福島 正樹, 日下 俊次  眼科手術  37-  (2)  451  -458  2024/04
  • 【眼科医の手引】未熟児網膜症と抗VEGF治療
    Kusaka S.  日本の眼科  95-  (2)  202  -203  2024/02
  • 未熟児網膜の診断と治療
    日下 俊次  日本眼科医会「眼科学術ビデオライブラリー」  2024/01
  • (会議録)KCNV2網膜症同胞例の長期経過
    佐藤 朋子, 國吉 一樹, 林 孝彰, 溝渕 圭, 西脇 弘一, 初川 嘉一, 中野 匡, 日下 俊次.  眼科臨床紀要  16-  (6)  456  -457  2023/06
  • (会議録)眼底所見が正常な錐体ジストロフィ
    國吉 一樹, 角田 和繁, 林 孝彰, 永江 由季, 藤波 芳, 須賀 晶子, 岩田 岳, 日下 俊次.  日本眼科学会雑誌  127-  (臨増)  250  -250  2023/03
  • 病院紹介-近畿大学病院-
    日下 俊次  日本小児眼科学会会報  (34)  41  -43  2023
  • An Instruction Manual of Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents for Retinopathy of Prematurity (2nd Edition)
    Terasaki H, Azume N, Kitaoka T, Kusaka S, Kondo H, Nishina S, Mori T, Yamada M, Yoshitomi T : Commottee for the Ophthalmic Management of Retinopathy of Prematurity  Journal of Japznese Ophthalmological Society  127-  (5)  570  -578  2023
  • 【未熟児網膜症アップデート】わかりやすい臨床講座 ROPの治療 硝子体手術・晩期合併症
    岩橋 千春, 日下 俊次  日本の眼科  93-  (10)  1410  -1415  2022/10
  • (会議録)ステロイド内服中に発症したStevens-Johnson症候群の一例.
    川口 奈都美, 岩橋 千春, 堀田 芙美香, 日下 俊次.  眼科臨床紀要  15-  (7)  495  -495  2022/07
  • (会議録)先天網膜分離症に対する硝子体手術の治療成績
    岩橋 千春, 松下 五佳, 近藤 寛之, 國吉 一樹, 日下 俊次.  眼科臨床紀要  15-  (6)  420  -420  2022/06
  • (会議録)未熟児網膜症に対するranibizumab単独投与治療後の経過
    歌村 翔子, 國吉 一樹, 岩橋 千春, 七部 史, 坂本 万寿夫, 和田 紀久, 日下 俊次.  眼科臨床紀要  15-  (6)  418  -419  2022/06
  • (会議録)未熟児網膜症-classic ROPとAROP(旧APROP)の病態と対応の違い- 未熟児網膜症に対する硝子体手術
    日下 俊次  日本眼科学会雑誌  (臨増)  34  -34  2022/03
  • (会議録)未熟児網膜症に対する抗VEGF治療
    日下 俊次  日本眼科学会雑誌  126-  (臨増)  2022/03
  • (会議録)我が国の家族性滲出性硝子体網膜症250家系の遺伝子解析
    近藤 寛之, 松下 五佳, 川村 朋子, 内尾 英一, 日下 俊次, 林 孝彰, 白澤 誠, 仁科 幸子, 金子 優, 川崎 良, 坂本 泰二  日本眼科学会雑誌  126-  (臨増)  203  -203  2022/03
  • (会議録)CTNNB1遺伝子変異を有する症候性家族性滲出性硝子体網膜症の臨床像
    成瀬 翔, 岡本 美里, 林 孝彰, 細野 克博, 堀田 喜裕, 岡島 道子, 渡邉 淳, 東 範行, 日下 俊次, 近藤 寛之  日本眼科学会雑誌  126-  (臨増)  203  -203  2022/03
  • (会議録)硝子体手術を要した瘢痕期未熟児網膜症の臨床的特徴と手術成績
    眞野 福太郎; 岩橋 千春; 國吉 一樹; 日下 俊次  日本眼科学会雑誌  126-  (臨増)  230  -230  2022/03
  • (会議録)網膜色素変性患者に対する白内障手術の術前・術後の視力経過
    永江 由季, 國吉 一樹, 萱澤 朋泰, 日下 俊次  日本眼科学会雑誌  126-  (臨増)  243  -243  2022/03
  • (会議録)線維柱帯切除後の悪性緑内障に対しirido-zonulo-hyaloido vitrectomyを行った1例
    野本 裕貴, 山田 泰生, 日下 俊次  眼科臨床紀要  15-  (3)  231  -232  2022/03
  • (会議録)先天網膜分離症の光干渉断層計検査所見
    中嶌 彩夏, 國吉 一樹, 岩橋 千春, 眞野 福太郎, 日下 俊次  眼科臨床紀要  158-  (158)  2022/02
  • (会議録)Visual snow syndromeの2例
    田村 佳菜子, 國吉 一樹, 堀田 芙美香, 日下 俊次  眼科臨床紀要  15-  (2)  159  -159  2022/02
  • (会議録)硝子体手術の進歩と難治性疾患への対処
    日下 俊次  眼科臨床紀要  15-  (2)  161  -161  2022/02
  • (会議録)日本人enhanced S-cone syndromeの臨床的および遺伝学的特徴
    林 孝彰, 溝渕 圭, 亀谷 修平, 國吉 一樹, 日下 俊次, 上野 真治, 西口 康二, 三宅 養三, 中野 匡  日本眼科学会雑誌  126-  (1)  7  -18  2022/01
  • (Q&A/特集)【眼科手術Q&A】網膜・硝子体 Coats病に対する硝子体手術の適切な手術介入時期とポイントについて教えてください
    眞野 福太郎, 日下 俊次  あたらしい眼科  38-  (臨増)  106  -109  2021/12
  • (会議録)W-60R挿入眼とLS-313 MF15挿入眼における立体視機能の検討
    酒井 邦章, 若山 暁美, 松本 富美子, 高田 遼太, 萱澤 朋泰, 日下 俊次  日本視能矯正学会プログラム抄録集62回  52  -52  2021/12
  • (会議録)帯状角膜変性症治療後のCorynebacterium propinquum角膜炎
    杉野 日彦, 江口 洋, 堀田 芙美香, 宮本 龍郎, 日下 俊次  眼科臨床紀要  14-  (12)  848  -848  2021/12
  • (会議録)複数回の角膜移植で失明を免れた淋菌性角結膜炎による角膜穿孔の1例
    中嶌 彩夏, 江口 洋, 堀田 芙美香, 日下 俊次  眼科臨床紀要  14-  (12)  848  -848  2021/12
  • Autologous peripheral retinal transplants in recalcitrant macular holes
    山田 桂子, 前野 貴俊, 日下 俊次, Arroyo Jorge G.  眼科臨床紀要  14-  (9)  613  -613  2021/09
  • (会議録)家族性滲出性網膜症様所見を呈したRubinstein-Taybi症候群の一例
    川口 奈都美, 遠藤 高生, 大久保 麻希, 山雄 さやか, 日下 俊次  眼科臨床紀要  14-  (8)  538  -538  2021/08
  • (会議録)DSAEK後の早期移植片機能不全にDMEKを施行した1例
    永江 由季, 江口 洋, 堀田 芙美香, 日下 俊次  眼科臨床紀要  14-  (8)  538  -538  2021/08
  • (会議録)錐体障害が優位なAZOORの長期予後
    國吉 一樹, 松本 長太, 日下俊次.  眼科臨床紀要  14-  (7)  448  -448  2021/07
  • Stage 4A未熟児網膜症術後の長期視力経過
    立花 都子, 岩橋 千春, 國吉 一樹, 阿部 考助, 日下 俊次.  眼科臨床紀要  14-  (6)  383  -384  2021/06
  • (会議録)Coats病における硝子体液および網膜下液のVEGF濃度の検討
    眞野 福太郎, 歌村 翔子, 近藤 千桜里, 大賀 智行, 日下 俊次  眼科臨床紀要  14-  (6)  383  -383  2021/06
  • (会議録)デスメ膜内皮移植術(DMEK)後2週間以内に視力が大幅に改善した3例
    若山 典子, 江口 洋, 堀田 芙美香, 日下 俊次  眼科臨床紀要  14-  (4)  251  -251  2021/04
  • (会議録)眼表面常在細菌に対する各種キノロン薬の抗菌活性
    川口 奈都美, 江口 洋, 堀田 芙美香, 日下 俊次, 西田 功一, 下村 嘉一  眼科臨床紀要  14-  (4)  252  -253  2021/04
  • 未熟児網膜症に対する抗VEGF治療後に硝子体手術を要した症例の臨床的特徴
    近藤 千桜里, 岩橋 千春, 國吉 一樹, 日下 俊次.  日本眼科学会雑誌  125-  (臨増)  206  -206  2021/03
  • (会議録)両眼同時白内障手術に用いたLS-313 MF15とW-60Rの臨床成績
    萱澤 朋泰, 日下 俊次  日本眼科学会雑誌  125-  (臨増)  189  -189  2021/03
  • (会議録)ヘッドマウント型視野計imoを用いた視野検査中のマイクロサッケードの評価
    石橋 拓也, 松本 長太, 野本 裕貴, 木村 伸司, 日下 俊次  日本眼科学会雑誌  125-  (臨増)  218  -218  2021/03
  • (会議録)網膜色素変性の視機能
    國吉 一樹, 佐藤 朋子, 上野 覚, 日下 俊次  日本眼科学会雑誌  125-  (臨増)  230  -230  2021/03
  • 間欠性外斜視の最大斜視角検出におけるPrism adaptation testとPatch testの比較検討
    高田 遼太, 松本 富美子, 若山 曉美, 梅原 郁美, 歌村 圭介, 成田 竜, 酒井 邦章, 下屋 美妃, 沼田 卓也, 七部 史, 岩田 明子, 阿部 考助, 日下 俊次.  日本視能訓練士協会誌  49-  223  -223  2020/12
  • (解説)治療法の再整理とアップデートのために 専門家による私の治療 未熟児網膜症
    佐藤 達彦, 日下 俊次  日本医事新報  (5042)  55  -56  2020/12
  • (会議録)夜盲をきたした非典型的な先天網膜分離症の1例
    永江 由季, 近藤 千桜里, 國吉 一樹, 日下 俊次  眼科臨床紀要  13-  (12)  816  -816  2020/12
  • (会議録)血管新生緑内障をきたした小児網膜中心静脈閉塞症の症例
    竹内 正興, 千原 智之, 嶋 千絵子, 盛 秀嗣, 大中 誠之, 高橋 寛二, 日下 俊次  眼科臨床紀要  13-  (12)  817  -817  2020/12
  • (解説)【屈折矯正に関する話題】小児白内障に対する眼内レンズの選択
    日下 俊次  あたらしい眼科  37-  (12)  1491  -1495  2020/12
  • (解説)未熟児網膜症に対する抗VEGF療法の手引き
    寺崎 浩子, 東 範行, 北岡 隆, 日下 俊次, 近藤 寛之, 仁科 幸子, 盛 隆興, 山田 昌和, 吉冨 健志, 未熟児網膜症眼科管理対策委員会, 日本眼科学会, 日本網膜硝子体学会, 日本小児眼科学会, 日本眼科医会  日本眼科学会雑誌  124-  (12)  1013  -1019  2020/12
  • (会議録)裂孔原性網膜剥離に対する硝子体手術後の非伏臥位の有用性について
    萱澤 朋泰, 國吉 一樹, 野本 裕貴, 杉岡 孝二, 日下 俊次  眼科臨床紀要  13-  (11)  762  -762  2020/11
  • (会議録)コロナ禍における手術運営
    中居 卓也, 谷 育美, 日下 俊次, 久保 修一  日本手術医学会誌  41-  (Suppl)  139  -139  2020/11
  • (会議録)朝顔症候群に伴う網膜剥離術後に網膜翻転を伴う再剥離を繰り返した1例
    佐藤 朋子, 國吉 一樹, 日下 俊次  眼科臨床紀要  14-  (11)  774  -774  2020/11
  • (会議録)脈絡膜皺襞を呈したANCA関連血管炎の1例
    岩橋 千春, 杉野 日彦, 上野 覚, 山雄 さやか, 坂本 万寿夫, 日下 俊次  眼科臨床紀要  13-  (11)  741  -741  2020/11
  • (会議録)Stage 4A未熟児網膜症に対する硝子体手術後再手術例の検討
    歌村 翔子, 國吉 一樹, 立花 都子, 日下 俊次  眼科臨床紀要  13-  (10)  689  -689  2020/10
  • (会議録)緑内障眼における24plus(1)測定点での視野評価
    野本 裕貴, 松本 長太, 杉野 日彦, 奥山 幸子, 日下 俊次  日本緑内障学会抄録集31回  165  -165  2020/10
  • (会議録)朝顔症候群に伴う網膜剥離に対する硝子体手術成績
    坂本 万寿夫, 國吉 一樹, 日下 俊次  眼科臨床紀要  13-  (10)  688  -688  2020/10
  • (会議録)角膜線維芽細胞におけるIL-1誘導性u-PA発現およびコラーゲン分解に対するエピガロカテキンガレートの効果
    吉田 浩二, 杉岡 孝二, 高橋 彩, 村上 純子, 三島 弘, 西田 輝夫, 日下 俊次  日本生化学会大会プログラム・講演要旨集93回  602  -602  2020/09
  • 抗Myelin oligodendrocyte glycoprotein(MOG)抗体陽性視神経炎の一例
    西田 功一, 青松 圭一, 七部 史, 日下 俊次  眼科臨床紀要  13-  (7)  497  -498  2020/07
  • 片眼性後天赤緑異常の1例
    大賀 智行, 國吉 一樹, 青松 圭一, 川崎 厚史, 日下 俊次  眼科臨床紀要  13-  (7)  492  -492  2020/07
  • 杉野 日彦, 國吉 一樹, 角田 和繁, 藤波 芳, 岩田 岳, 櫻本 宏之, 櫻本 宏之, 初川 嘉一, 日下 俊次.  眼科臨床紀要  13-  (6)  2020/06
  • 視力低下を呈したIgG4関連疾患の1例
    武田 麻希, 岩田 明子, 萱澤 朋泰, 石橋 拓也, 七部 史, 中尾 雄三, 日下 俊次  13-  (5)  366  -366  2020/05
  • 間欠性外斜視の術後経過における斜視角の変化と融像幅の関係
    成田 竜, 若山 曉美, 梅原 郁美, 歌村 圭介, 松本 富美子, 阿部 考助, 七部 史, 沼田 卓也, 日下 俊次.  眼科臨床紀要  13-  (4)  277  -278  2020/04
  • 日常生活における視野異常の自覚と両眼視野セルフチェックシートの有用性について
    石橋 眞里佳, 松本 長太, 奥山 幸子, 野本 裕貴, 七部 史, 萱澤 朋泰, 江浦 真理子, 日下 俊次.  日本眼科学会雑誌  124-  (臨増)  178  -178  2020/03
  • 間欠性外斜視の最大斜視角検出におけるPrism adaptation testとPatch testの比較検討
    高田 遼太, 松本 富美子, 若山 曉美, 梅原 郁美, 歌村 圭介, 成田 竜, 酒井 邦章, 下屋 美妃, 沼田 卓也, 七部 史, 岩田 明子, 阿部 考助, 日下 俊次.  日本視能矯正学会プログラム抄録集  60回-  58  -58  2019/11
  • 網膜芽細胞腫に伴う硝子体出血に対して硝子体手術を行った1例
    西田 功一, 日下 俊次, 今井 尚徳, 國吉 一樹, 森本 壮, 鈴木 茂伸.  眼科臨床紀要  12-  (10)  783  2019/10
  • 青錐体1色覚の新規遺伝子変異
    國吉 一樹, 林 孝彰, 岩佐 真紀, 山下 高廣, 上山 久雄, 片桐 聡, 櫻本 宏之, 宇野 直樹, 七田 芳則, 日下 俊次.  眼科臨床紀要  12-  (10)  2019/10
  • 重症未熟児網膜症(ROP)に対する抗VGEF治療後の再燃例の検討
    歌村 翔子, 國吉 一樹, 初川 嘉一, 藤野 貴啓, 杉岡 孝二, 日下 俊次.  眼科臨床紀要  12-  (10)  792  -792  2019/10
  • 近藤 千桜里, 國吉 一樹, 林 孝彰, 亀谷 修平, 片桐 聡, 久保田 大紀, 櫻本 宏之, 藤波 芳, 角田 和繁, 岩田 岳, 日下 俊次.  眼科臨床紀要  12-  (9)  727  -727  2019/09
  • 武田 麻希, 西田 功一, 福田 昌彦, 高橋 彩, 江口 洋, 濱田 傑, 天野 史郎, 日下 俊次.  眼科臨床紀要  12-  (9)  727  2019/09
  • (会議録)日常生活における視野異常の自覚とクワトロチェッカーの有用性
    石橋 眞里佳, 松本 長太, 奥山 幸子, 野本 裕貴, 七部 史, 萱澤 朋泰, 江浦 真理子, 日下 俊次.  第30回日本緑内障学会抄録集  146  -146  2019/09
  • 視野測定プログラムAIZE、AIZE-EXにおける検査結果の変動
    野本 裕貴, 松本 長太, 吉川 啓司, 南野 麻美, 奥山 幸子, 木村 伸司, 日下 俊次.  第30回日本緑内障学会抄録集  30回-  147  -147  2019/09
  • 國吉 一樹, 亀谷 修平, 林 孝彰, 櫻本 宏之, 久保田 大紀, 片桐 聡, 藤波 芳, 角田 和繁, 岩田 岳, 日下 俊次.  眼科臨床紀要  12-  (8)  641  -641  2019/08
  • 杉野 日彦, 國吉 一樹, 角田 和繁, 藤波 芳, 岩田 岳, 櫻本 宏之, 初川 嘉一, 日下 俊次.  眼科臨床紀要  12-  (8)  655  -655  2019/08
  • 日下 俊次  眼科臨床紀要  12-  (8)  656  -656  2019/08
  • 中居 卓也, 谷 育美, 日下 俊次  日本手術医学会誌  40-  (Suppl.)  163  -163  2019/07
  • 佐藤 朋子, 福田 昌彦,西田 功一, 高橋 彩, 南 毅, 日下 俊次.  眼科臨床紀要  12-  (6)  511  -511  2019/06
  • 石橋 眞里佳, 萱澤 朋泰, 堀田 芙美香, 奥山 幸子, 江口 洋, 日下 俊次.  眼科臨床紀要  12-  (5)  421  -422  2019/05
  • 西田 功一, 杉岡 孝二, 村上 純子, 岡田 清孝, 西田 輝夫, 日下 俊次.  日本結合組織学会学術大会プログラム・抄録集  51回-  115  -115  2019/05
  • Stickler症候群患者における中心窩網膜低形成(Foveal Hypoplasia in Patients with Stickler Syndrome)
    松下 五佳, 永田 竜郎, 林 孝彰, 木許 賢一, 久保田 敏昭, 大路 正人, 日下 俊次, 近藤 寛之.  眼科臨床紀要  12-  (3)  237  -237  2019/03
  • OCT angiographyでできること、今後の展望について 非侵襲的に血管像を層別に観察でき、今後ますます普及が期待される
    飯田 知弘, 日下 俊次  週刊日本医事新報  (4950)  59  -60  2019/03
  • (会議録)小児白内障手術におけるoptic capture法の有用性の検討
    岩田 明子, 日下 俊次, 立花 都子, 阿部 考助, 辻岡 大志, 下村 嘉一.  眼科臨床紀要  12-  (3)  250  -250  2019/03
  • (会議録)簡易的な視野異常自己診断チェックツール(クワトロチャート)の有用性
    石橋 眞里佳, 松本 長太, 奥山 幸子, 橋本 茂樹, 野本 裕貴, 七部 史, 江浦 真理子, 萱澤 朋泰, 日下 俊次.  日本眼科学会雑誌  123-  (臨増)  158  -158  2019/03
  • (会議録)マリオット盲点近傍に感度低下を有する眼におけるHeijl-Krakau法での固視不良応答
    石橋 拓也, 松本 長太, 野本 裕貴, 奥山 幸子, 七部 史, 山雄 さやか, 吉川 啓司, 南野 麻美, 日下 俊次.  日本眼科学会雑誌  123-  (臨増)  158  -158  2019/03
  • (会議録)新たな視野測定プログラムAIZE-EX
    野本 裕貴, 松本 長太, 吉川 啓司, 南野 麻美, 奥山 幸子, 山雄 さやか, 木村 伸司, 日下 俊次.  日本眼科学会雑誌  123-  (臨増)  158  -158  2019/03
  • (会議録)次世代シークエンス技術を用いた周術期の眼表面菌叢解析
    堀田 芙美香, 江口 洋, 桑原 知巳, 今大路 治之, 日下 俊次.  日本眼科学会雑誌  123-  (臨増)  225  -225  2019/03
  • (会議録)未熟児網膜症に対するranibizumab硝子体内投与後の血清VEGF濃度
    歌村 翔子, 國吉 一樹, 杉岡 孝二, 小西 悠平, 南方 俊祐, 和田 紀久, 日下 俊次.  日本眼科学会雑誌  123-  (臨増)  230  -230  2019/03
  • (会議録)近畿大学におけるデスメ膜内皮移植術(DMEK)の術後早期成績
    江口 洋, 大賀 智行, 堀田 芙美香, 日下 俊次.  眼科臨床紀要  12-  (2)  160  -160  2019/02
  • (会議録)静的視野検査中の固視微動測定
    石橋 拓也, 松本 長太, 野本 裕貴, 奥山 幸子, 梅原 郁美, 若山 暁美, 日下 俊次.  眼科臨床紀要  12-  (1)  77  -77  2019/01
  • (会議録)小児白内障手術におけるoptic captureの有用性
    岩田 明子, 立花 都子, 阿部 考助, 日下 俊次.  眼科臨床紀要  11-  (12)  934  -934  2018/12
  • 未熟児網膜症診療の現状と治療、適応とタイミングは? レーザー網膜光凝固法が90%以上の症例で有効。最近、抗VEGF治療が開発された
    日下 俊次, 古泉 英貴.  日本医事新報  (4932)  56  -56  2018/11
  • (会議録)再燃を繰り返し、長期にわたる治療を要したvon Hippel-Lindau病の1例
    立花 都子, 日下 俊次, 辻岡 大志, 下村 嘉一  眼科臨床紀要  11-  (11)  854  -854  2018/11
  • 転換期を迎えつつある未熟児網膜症の治療
    日下 俊次  九州医事新報  (11月号)  2018/10
  • (会議録)硝子体手術を行った重症Coats病の視機能予後
    立花 都子, 日下 俊次, 阿部 考助, 辻岡 大志, 國吉 一樹, 下村 嘉一.  眼科臨床紀要  11-  (9)  716  -717  2018/09
  • (会議録)硝子体手術を行った重症Coats病の視機能長期予後
    立花 都子, 日下 俊次, 阿部 考助, 辻岡 大志, 國吉 一樹, 下村 嘉一.  日本眼科学会雑誌  122-  (7)  530  -530  2018/07
  • (会議録)小児無水晶体眼に対するコンタクトレンズ処方
    立花 都子, 日下 俊次, 阿部 考助, 國吉 一樹, 辻岡 大志, 宮本 裕子, 下村 嘉一.  眼科臨床紀要  11-  (6)  476  -477  2018/06
  • (会議録)裂孔併発し治療に難渋した重症Coats病の1例
    辻岡 大志, 日下 俊次, 立花 都子, 高井 保幸, 下村 嘉一.  眼科臨床紀要  11-  (6)  478  -478  2018/06
  • (会議録)レバミピド点眼後の涙嚢炎発生機序に関する研究
    長谷川 麻里子, 江口 洋, 堀田 芙美香, 日下 俊次, 宮崎 千歌, 廣瀬 美央, 竹谷 太, 佐々木 次壽, 井上 康, 下村 嘉一.  眼科臨床紀要  11-  (4)  318  -318  2018/04
  • (会議録)Stickler症候群における傍血管網膜変性部の視機能
    冨士本 一志, 永田 竜朗, 松下 五佳, 林 孝彰, 日下 俊次, 近藤 寛之.  日本眼科学会雑誌  122-  (臨増)  194  -194  2018/03
  • 未熟児網膜症 最近の動向
    日下 俊次  日本眼科学会雑誌  122-  (2)  91  -93  2018/02
  • (会議録)MRワクチン接種後に発症した重篤な視細胞変性
    佐藤 朋子; 國吉 一樹; 初川 嘉一; 木村 貞美; 藤野 貴啓; 大黒 浩; 中井 理恵; 角南 健太; 三島 壮一郎; 日下 俊次; 鈴木 保宏; 下村 嘉一  眼科臨床紀要  11-  (1)  77  2018/01
  • (会議録)水晶体再建術後に良好な視機能が得られた小児マルファン症候群の一例
    百海 紗弥香, 阿部 考助, 日下 俊次, 立花 都子, 松本 富美子, 田中 玲湖, 西岡 由加里, 飯尾 早也香, 萱澤 真梨子, 三島 弘.  日本視能訓練士協会誌  46-  295  -296  2017/12
  • (会議録)重症未熟児網膜症に対するranibizumab硝子体内投与
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 小西 悠平, 南方 俊祐, 和田 紀久, 松本 長太, 下村 嘉一  眼科臨床紀要  10-  (11)  918  -918  2017/11
  • 家族性滲出性硝子体網膜症と小頭症
    近藤 寛之, 松下 五佳, 奥 一真, 内尾 英一, 林 孝彰, 日下 俊次.  眼科臨床紀要  10-  (10)  860  -860  2017/10
  • (会議録)超早産児の慢性肺疾患の発現抑制効果を評価するための遺伝子組換えヒトIGF-1/IGFBP-3製剤の国際共同第IIb/III相試験デザイン
    平野 慎也, 早川 昌弘, 河井 昌彦, 日下 俊次, 中村 友彦, Mangili A,Hamdani M,; Pavia R, Barton N, 楠田 聡.  日本新生児成育医学会雑誌  29-  (3)  729  -729  2017/10
  • (会議録)重症未熟児網膜症に対するranibizumab硝子体内投与
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 小西 悠平, 南方 俊祐, 和田 紀久, 松本 長太, 下村 嘉一.  眼科臨床紀要  10-  (9)  783  -783  2017/09
  • (会議録)1歳男児に急性発症した重篤な網膜機能障害
    佐藤 朋子; 國吉 一樹; 初川 嘉一; 木村 貞美; 藤野 貴啓; 角南 健太; 大黒 浩; 三島 壮一郎; 日下 俊次; 下村 嘉一  眼科臨床紀要  10-  (7)  581  -582  2017/07
  • 小児白内障に対するトーリック眼内レンズ挿入眼の術後視機能
    立花 都子, 日下 俊次, 阿部 考助, 辻岡 大志, 小池 英子, 江口 洋, 下村 嘉一.  眼科臨床紀要  10-  (6)  506  -506  2017/06
  • 小児網膜疾患に対する両眼同日手術
    辻岡 大志, 日下 俊次, 國吉 一樹, 杉岡 孝二, 下村 嘉一  眼科臨床紀要  10-  (6)  514  -515  2017/06
  • Todorich B,Thanos A,Yonekawa Y,Thomas BJ,Faia LJ,Chang E,Shulman J,Olsen KR,Blair MP,Shapiro MP,Ferrone P,Vajzovic L,Toth CA,Lee TC,Robinson J,Hubbard B, Kondo H,Besirli CG,Nudleman E,Wong SC,Kusaka S,Walsh M,Chan RVP,Berrocal A,Caputo G,Murray TG,Sears J,Schunemann R,Harper CA 3rd,Kychental A,Dorta P,Cernichiaro-Espinosa LA,Wu WC,Campbell JP,Martinez-Castellanos MA,Quiroz-Mercado H,Hayashi H,Quiram P,Amphornphruet A,Hartnett ME,Tsui I,Ells A,John V,Moshfeghi D,Capone A Jr,Drenser KA,Trese MT.  Retina  37-  (5)  e52  -e54  2017/05
  • Todorich B; Thanos A; Yonekawa Y; Thomas BJ; Faia LJ; Chang E; Shulman J; Olsen KR; Blair MP; Shapiro MP; Ferrone P; Vajzovic L; Toth CA; Lee TC; Robinson J; Hubbard B; Kondo H; Besirli CG; Nudleman E; Wong SC; Kusaka S; Walsh M; Chan RVP; Berrocal A; Caputo G; Murray TG; Sears J; Schunemann R; Harper CA; Kychental A; Dorta P; Cernichiaro-Espinosa LA; Wu WC; Campbell JP; Martinez-Castellanos MA; Quiroz-Mercado H; Hayashi H; Quiram P,Amphornphruet A; Hartnett ME; Tsui I; Ells A; John V; Moshfeghi D; Capone A; Drenser KA; Trese MT  Retina  37-  (5)  e52  -e54  2017/05
  • 眼科図譜 術中 Optical Coherence Tomography (RESCAN®700)
    江口 洋, 日下 俊次, 堀田 芙美香, 福田 昌彦, 下村 嘉一.  臨床眼科  71-  (4)  509  -513  2017/04
  • 小児でのToric IOL使用成績とoptic captureの影響
    立花 都子, 日下 俊次, 阿部 考助, 辻岡 大志, 堀田 芙美香, 江口 洋, 下村 嘉一.  日本眼科学会雑誌  121-  (臨増)  191  -191  2017/03
  • Corynebacterium oculiの薬剤感受性
    堀田 芙美香, 江口 洋, 日下 俊次, 福田 昌彦, 下村 嘉一, 今大路 治之, 桑原 知巳, Bernard K, Vandamme P.  日本眼科学会雑誌  121-  (臨増)  198  -198  2017/03
  • 術前眼表面の培養結果と分離菌のキノロン感受性
    西田 功一, 江口 洋, 堀田 芙美香, 立花 都子, 辻岡 大志, 日下 俊次, 福田 昌彦, 下村 嘉一.  日本眼科学会雑誌  121-  (臨増)  199  -199  2017/03
  • Stickler症候群に見られる網膜傍血管変性の眼底自発蛍光所見
    冨士本 一志, 永田 竜朗, 松下 五佳, 林 孝彰, 久保田 敏昭, 大路 正人, 日下 俊次, 近藤 寛之.  日本眼科学会雑誌  121-  (臨増)  190  -190  2017/03
  • 【小児眼科Q&A】 先天性疾患・小児疾患 眼内レンズ選択の考え方を教えてください
    岩田 明子, 日下 俊次  あたらしい眼科  33-  (臨増)  210  -212  2016/11
  • 小児家族性滲出性硝子体網膜症に対する硝子体手術成績
    辻岡 大志, 日下 俊次, 杉岡 孝二, 國吉 一樹, 下村 嘉一.  眼科臨床紀要  9-  (10)  844  -845  2016/10
  • 未熟児網膜症に対する水晶体温存硝子体術後の水晶体透明性
    立花 都子, 日下 俊次, 阿部 考助, 森本 壮, 國吉 一樹, 杉岡 孝二, 岩橋 千春, 不二門 尚, 下村 嘉一.  眼科臨床紀要  9-  (9)  773  -773  2016/09
  • Kondo H, Uchio E, Hayashi T, Nishina S, Azuma N, Kusaka S.  Invest Ophthalmol Vis Sci.  57-  (12)  2016/09
  • 先天網膜分離症に網膜内層切除術を施行した1例
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 松本 長太, 下村 嘉一, 近藤 寛之.  眼科臨床紀要  9-  (5)  449  -449  2016/05
  • 経口フルオレセインを用いた超広角蛍光眼底撮影の試み
    辻岡 大志, 日下 俊次, 高田 遼太, 松本 富美子, 立花 都子, 小池 英子, 江口 洋, 下村 嘉一.  眼科臨床紀要  9-  (4)  371  -371  2016/04
  • 角膜移植術における術中real-time OCT(RESCAN 700)
    江口 洋, 小池 英子, 立花 都子, 辻岡 大志, 日下 俊次, 福田 昌彦, 下村 嘉一.  日本眼科学会雑誌  120-  (臨増)  295  -295  2016/03
  • 未熟児網膜症に対する水晶体温存硝子体術後の水晶体透明性
    立花 都子, 日下 俊次, 阿部 考助, 森本 壮, 國吉 一樹, 杉岡 孝二, 岩橋 千春, 不二門 尚, 下村 嘉一.  日本眼科学会雑誌  120-  (臨増)  192  -192  2016/03
  • 重症未熟児網膜症に対してranibizumab硝子体内投与を施行した3症例
    平木 翔子, 杉岡 孝二, 國吉 一樹, 日下 俊次, 下村 嘉一.  眼科臨床紀要  9-  (3)  292  -292  2016/03
  • Kusaka S, Tachibana K, Shimomura Y.  Ophthalmologica  236-  59  -59  2016
  • 日下 俊次  日本医師会雑誌 = The Journal of the Japan Medical Association  144-  (9)  1795  -1798  2015/12
  • 硝子体手術後の未熟児網膜症例の5歳時視機能
    立花 都子, 日下 俊次, 阿部 考助, 國吉 一樹, 杉岡 孝二, 松本 富美子, 下村 嘉一.  眼科臨床紀要  8-  (11)  853  -853  2015/11
  • 広角眼底観察システム用曇り防止装置の臨床応用
    日下 俊次, 辻岡 大志, 立花 都子, 小池 英子, 檜垣 史郎, 下村 嘉一.  眼科臨床紀要  8-  (10)  757  -757  2015/10
  • Kondo H, Matsushita I, Tahira T, Uchino E, Kusaka S.  iVOS  56-  (7)  2015/06
  • コーツ病に対するbevacizumab併用治療の効果
    立花 都子, 日下 俊次, 初川 嘉一, 今泉 綾子, 兒玉 達夫, 下村 嘉一.  日本眼科学会雑誌  119-  (臨増)  261  -261  2015/03
  • ヘルペスと闘った37年
    下村 嘉一, 松本 長太, 福田 昌彦, 奥山 幸子, 國吉 一樹, 杉岡 孝二, 板橋 幹城, 橋本 茂樹,青松 圭一, 七部 史, 野本 裕貴, 渡邊 敬三, 河本 庄平, 児玉 彩, 坂本 万寿夫, 日下 俊次, 檜垣 史郎, 小池 英子, 立花 都子, 辻岡 大志, 三島 弘, 阿部 考助, 萱澤 朋泰, 萱澤 真梨子, 藤田 貢, 義江 修.  日本眼科学会雑誌  119-  (3)  145  -167  2015/03
  • 知っておきたい小児眼科の最新知識 2)重症未熟児網膜症には光凝固?それとも抗VEGF治療?
    Kusaka S.  臨床眼科  69-  (2)  204  -208  2015/02
  • RESCAN 700の使用経験
    日下俊次  New letter from Carl Zeiss Meditec Insight 2  17-  2015/01
  • 【未熟児網膜症アップデート】わかりやすい臨床講座 未熟児網膜症 最近の手術的治療と今後の展望(解説)
    日下 俊次  日本の眼科  85-  (12)  19  -22  2014/12
  • Mittendorf spotを伴う不同視弱視の2症例
    福光 実里, 松本 富美子, 立花 都子, 小池 英子, 七部 史, 阿部 考助, 日下 俊次.  日本視能訓練士協会誌  43-  336  -337  2014/12
  • 未熟児網膜症の最新治療
    日下 俊次  眼科手術  27-  (4)  579  -552  2014/10
  • [Weekly on-line newspaper] Bevacizumab appears beneficial for ROP in zone II
    Kuniyoshi K, Sugioka K, Sakuramoto H, Kusaka S, Wada N, Shimomura Y.  Academy Express Asia Pacific Edition  2014/06
  • 佐藤 達彦; 日下 俊次  臨床眼科  68-  (5)  616  -622  2014/05
  • 未熟児網膜症に対するベバシズマブ単独治療の成績(会議録)
    國吉 一樹, 杉岡 孝二, 櫻本 宏之, 辻岡 大志, 日下 俊次, 下村 嘉一, 和田 紀久.  眼科臨床紀要  7-  (5)  381  -381  2014/05
  • 前房内に迷入した空気により瞳孔ブロックを来した小児の1例
    藤井 明子, 日下 俊次, 河本 庄平, 青松 圭一, 小池 英子, 立花 都子, 檜垣 史郎, 下村 嘉一.  眼科臨床紀要  7-  (5)  382  -383  2014/05
  • 日下 俊次.  Graphic journal of ophthalmology  3-  (1)  39  -43  2014/02
  • (会議録)ベバシズマブ硝子体注射とPDTを施行した小児に発症したVHL病による網膜血管腫の1例
    馬場 高志, 三宅 敦子, 山崎 厚志, 日下 俊次, 井上 幸次.  眼科臨床紀要  6-  (12)  992  -992  2013/12
  • (会議録)Mittendorf spotを伴う不同視弱視の2症例
    Fukumitsu M, Matsumoto F, Tachibana K, Koike E, Tanabe F, Abe K, Kusaka S.  日本視能矯正学会プログラム抄録集  54回-  77  -77  2013/11
  • ウロキナーゼ型プラスミノーゲン活性化因子によるRPEのコラーゲンゲル内遊走作用(会議録)
    杉岡 孝二, 児玉 彩, 岩田 美穂子, 岡田 清孝, 日下 俊次, 松本 長太, 下村 嘉一.  眼科臨床紀要  6-  (10)  805  -805  2013/10
  • 水晶体嚢を有しない眼に対する眼内レンズ強膜内固定法の短期成績(会議録)
    河本 庄平, 日下 俊次, 藤井 明子, 青松 圭一, 小池 英子, 立花 都子, 檜垣 史郎, 下村 嘉一  眼科臨床紀要  6-  (10)  815  -815  2013/10
  • 手術相談室 症例呈示 自傷行為のある知的障害者の白内障と網膜剥離の手術(Q&A)
    永原 幸, 日下 俊次, 大島 佑介, 池田 恒彦, 井上 真  眼科手術  26-  (3)  437  -443  2013/07
  • Peters奇形を伴った未熟児網膜症に対する治療(会議録)
    南 毅, 国吉 一樹, 日下 俊次, 櫻本 宏之, 福田 昌彦, 松本 長太, 伊藤 久太郎, 下村 嘉一.  眼科臨床紀要  6-  (5)  404  -404  2013/05
  • 日下 俊次  日本眼科學会雜誌  117-  (3)  317  -317  2013/03
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  Japanese Journal of Clinical Ophthalmology  66-  (12)  1623  -1632  2012/11
  • Peters奇形を伴った未熟児網膜症に対する治療(会議録)
    南 毅, 國吉 一樹, 日下 俊次, 坂本 万寿夫, 櫻本 宏之, 杉岡 孝二, 福田 昌彦, 松本 長太, 伊藤 久太朗, 下村 嘉一.  眼科臨床紀要  5-  (11)  1064  -1064  2012/11
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  Japanese Journal of Clinical Ophthalmology  66-  (10)  1450  -1459  2012/10
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (9)  1290  -1298  2012/09
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (8)  1120  -1127  2012/08
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (7)  958  -968  2012/07
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (6)  786  -792  2012/06
  • 重症未熟児網膜症に対する抗VEGF治療(解説)
    日下 俊次  日本未熟児新生児学会雑誌  24-  (2)  213  -216  2012/06
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (5)  590  -596  2012/05
  • 【超低出生体重児-最新の管理・治療と予後】未熟児網膜症に対する抗VEGF治療
    日下 俊次  周産期医学  42-  (5)  573  -576  2012/05
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (4)  402  -408  2012/04
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (3)  242  -248  2012/03
  • Kusaka S.  Journal of the eye  29-  (2)  183  -187  2012/02
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (2)  148  -154  2012/02
  • アイカップ法により得られた検体の細菌、真菌、ウイルスDNA(会議録)
    河本 庄平, 檜垣 史郎, 板橋 幹城, 福田 昌彦, 萱澤 朋泰, 青松 圭一, 立花 都子, 日下 俊次, 中尾 雄三, 下村 嘉一.  眼科臨床紀要  5-  (2)  182  -182  2012/02
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  臨床眼科  66-  (1)  12  -19  2012/01
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  Japanese Journal of Clinical Ophthalmology  65-  (13)  1874  -1880  2011/12
  • Kita M, Kimura H, Kusaka S, Kuriyama S, Saito Y, Tsukahara Y, Yasuhara T.  Japanese Journal of Clinical Ophthalmology  65-  (12)  1786  -1793  2011/11
  • Stage 3未熟児網膜症に対するbevacizumab硝子体内投与の短期成績
    日下 俊次; 荒堀 仁美; 和田 和子; 岩橋 千春; 佐藤 達彦  眼科臨床紀要  4-  (10)  993  -993  2011/10
  • 重症未熟児網膜症に対する抗VEGF治療(会議録)
    日下 俊次  日本未熟児新生児学会雑誌  23-  (3)  448  -448  2011/10
  • 佐藤 達彦, 日下 俊次.  眼科  53-  (10)  1489  -1493  2011/09
  • (会議録)Bevacizumab硝子体内投与のみで寛解したAP-ROPの一例
    遠藤 高生; 日下 俊次; 荒堀 仁美; 和田 和子; 國吉 一樹; 黒田 聡; 森本 壮; 不二門 尚  眼科臨床紀要  4-  (5)  472  -472  2011/05
  • 未熟児網膜症に対する硝子体手術後の続発緑内障(会議録)
    島 千春, 日下 俊次, 大鳥 安正, 三木 篤也, 松下 賢治, 木内 良明, 不二門 尚.  眼科臨床紀要  3-  (4)  405  -405  2010/04
  • 特異な眼振からLeber先天盲が判明した1症例(会議録)
    本岡 麻由, 森本 壮; 松下 賢治, 日下 俊次, 不二門 尚, 富永 康仁.  眼科臨床紀要  3-  (3)  289  -290  2010/03
  • 各科臨床のトピックス 重症未熟児網膜症に対する治療法の進歩(解説)
    Kusaka S.  Journal of the Japan Medical Association)  138-  (8)  1588  -1589  2009/11
  • 未熟児網膜症に対する硝子体手術後の続発緑内障(会議録)
    島 千春, 日下 俊次, 大鳥 安正, 張野 正誉, 三木 篤也, 松下 賢治, 木内 良明, 岡田 守生, 不二門 尚  日本眼科学会雑誌  113-  (10)  992  -993  2009/10
  • Sato T, Kusaka S.  Journal of the eye  26-  (4)  481  -486  2009/04
  • 田野保雄; 瓶井資弘; 生野恭司; 辻川元一; 坂口裕和; 西田健太郎; 方肖雲; 杜兆江; 謝平; 不二門尚; 日下俊次; 森本壮; 中内一揚; 別所建一郎; 下條裕史; 大川賀孝; 北口善之; 福田淳; 澤井元; 三好智満; 八木哲也; 小山内実; 宋文杰; 三宅養三; 近藤峰生; 子安俊行; 坂井隆夫; 栗本幸英; 平形明人; 大路正人; QUIROZ‐MERCADO Hugo; USTARIZ‐GONZALEZ Orlando; CECILIA‐GONZALEZ Carmen; 太田淳; 徳田崇; 小澤素生; 古野間邦彦; 鐘堂健三; 大澤孝治; 中谷正義  日本眼科学会雑誌  113-  (3)  315  -343  2009/03
  • 佐藤 達彦, 日下 俊次  眼科  50-  (11)  1721  -1727  2008/10
  • 日下 俊次  ジャパンメディカルソサエティ  (134)  92  -95  2008/02
  • Kusaka S.  Journal of ophthalmic surgery  21-  (1)  68  -69  2008/01
  • 日下 俊次  臨床眼科  62-  (1)  9  -14  2008/01
  • 網膜中心静脈閉塞症による黄斑浮腫に対するBevacizumab(アバスチン)の効果(会議録)
    上野 千佳子(大阪大学), 瓶井 資弘, 沢 美喜, 坂口 裕和, 辻川 元一, 大島 佑介, 生野 恭司, 五味 文, 日下 俊次, 田野 保雄.  眼科臨床医報会  101-  (9)  978  -978  2007/09
  • Kusaka S.  Journal of ophthalmic surgery  19-  (3)  345  -348  2006/07
  • Kusaka S, Fujikado T.  Journal of the eye  23-  (1)  1  -2  2006/01
  • Sato T, Kusaka S  Journal of the eye  23-  (1)  33  -37  2006/01
  • 日下 俊次, 白神 史雄  Journal of the eye  22-  (10)  1369  -1370  2005/10
  • 小児白内障の手術成績(会議録)
    牧野 里砂, 日下 俊次, 三浦 和美, 細畠 淳, 田野 保雄, 不二門 尚.  眼科臨床医報  99-  (7)  605  -605  2005/07
  • Kusaka S, Ikuno Y, Oshima Y, Sakaguchi H, Gomi F, Kamei M, Ohji M, Tano Y.  Invest Ophthalmol Vis Sci.  46-  (13)  774  -774  2005/05
  • (会議録)CNV同時抜去を併用した強膜短縮黄斑移動術
    崎元 晋, 瓶井 資弘, 坂口 裕和, 大島 佑介, 生野 恭司, 五味 文, 日下 俊次, 大路 正人, 田野 保雄.  眼科臨床医報  99-  (3)  267  -267  2005/03
  • 日下 俊次  小児科診療  67-  (8)  1242  -1248  2004/08
  • 日下 俊次  Journal of ophthalmic surgery  17-  (3)  301  -306  2004/07
  • 松尾 俊彦, 日下 俊次.  眼科  46-  (4)  605  -609  2004/04
  • 日下 俊次, 吉田 宗徳  Journal of the eye  20-  (12)  1679  -1680  2003/12
  • Kusaka S.  Journal of ophthalmic surgery  16-  (4)  517  -519  2003/10
  • Sayanagi K, Ikuno Y, Sawa M, Gomi F, Kamei M, Kusaka S, Ohji M, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  44-  U89  -U89  2003/05
  • Kusaka S, Makino R, Ohji M, Kamei M, Ikuno Y, Gomi F, Saito Y, Hayashi A, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  44-  U489  -U489  2003/05
  • Cekic O, Keserci B, Ohji M, Sawa M, Hayashi A, Ikuno Y, Nakata K, Gomi F, Kusaka S, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  43-  U984  -U984  2002/05
  • 網膜色素上皮細胞における2つの内向き整流性K+チャネル(Kir4.1,Kir7.1)の発現と局在の違い(会議録)
    日下 俊次, 稲野辺 厚, 藤田 秋一, 間木野 泰祥, 種本 雅之, 松下 賢治, 田野 保雄, 倉智 嘉久.  日本眼科学会雑誌  105-  (臨増)  253  -253  2001/03
  • 網膜色素上皮細胞における2つの内向き整流性K+チャネル(Kir4.1,Kir7.1)の発現と局在の違い(会議録)
    日下 俊次, 堀尾 嘉幸, 藤田 秋一, 稲野辺 厚, 松下 賢治, 田野 保雄, 倉智 嘉久.  日本眼科学会雑誌  105-  (臨増)  253  -253  2001/03
  • Sawa M, Saito Y, Ikuno Y, Hayashi A, Kusaka S, Ohji M, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  42-  (4)  S428  -S428  2001/03
  • Shimojyo H, Fujikado T, Hosobata J, Hayashi A, Kusaka S, Ohji M, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  42-  (4)  S169  -S169  2001/03
  • 日下 俊次  あたらしい眼科  17-  113  -115  2001/01
  • ラット網膜色素上皮細胞における内向き整流性K+チャネル(Kir7.1)の発現(会議録)
    日下 俊次, 稲野辺 厚, 間木野 泰祥, 松下 賢治, 田野 保雄, 倉智 嘉久.  104-  (臨増)  216  -216  2000/03
  • Tano Y, Nakata K, Ohji M, Kusaka S, Hayashi A, Kamei M, Fujikado T.  Invest Ophthalmol Vis Sci.(IVOS)  41-  (4)  S540  -S540  2000/03
  • Ohji M, Takashima H, Kusaka S, Hayashi A, Saito Y, Kamei M, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  41-  (4)  S656  -S656  2000/03
  • Hayashi A, Hayashi S, Fang XY, Morimoto T, Osman A, Usui S, Kusaka S, Ohji M, Fujikado T, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  41-  (4)  S181  -S181  2000/03
  • Kusaka S, Inanobe A, Makino Y, Matsushita K, Tano Y, Kurachi Y.  Invest Ophthalmol Vis Sci.(IVOS)  41-  (4)  S492  -S492  2000/03
  • Morimoto T, Hayashi A, Fujikado T, Fang XY, Kamei M, Kusaka S, Ohji M, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  41-  (4)  S889  -S889  2000/03
  • 日下 俊次  Neuro-ophthalmology Japan  16-  (1)  10  -14  1999/03
  • 内向き整流K+チャネル(KAB-2/Kir4.1)の網膜色素上皮細胞における発現と細胞内局在(会議録)
    日下 俊次, 堀尾 嘉幸, 藤田 秋一, 稲野辺 厚, 松下 賢治, 田野 保雄, 倉智 嘉久  日本眼科学会雑誌  103-  (臨増)  58  -58  1999/03
  • 網膜色素上皮細胞における内向き整流K1チャネル(KAB-2/Kir4.1)の発現とその局在(会議録)
    日下 俊次, 堀尾 嘉幸, 藤田 秋一, 稲野辺 厚, 松下 賢治, 田野 保雄, 倉智 嘉久.  日本薬理学雑誌  103-  (臨増)  46  -46  1999/03
  • イヌ眼における強膜短縮を用いた網膜移動術
    林 篤志, 臼井 審一, 川口 清富, 藤岡 佐由里, 日下 俊次, 大路 正人, 不二門 尚, 田野 保雄.  日本眼科学会雑誌  103-  (臨増)  128  -128  1999/03
  • Hayashi A, Usui S, Kawaguchi K, Fujioka S, Kusaka S, Fujikado T, Ohji M, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  40-  (4)  S710  -S710  1999/03
  • Ohji M, Harino S, Saito Y, Kusaka S, Okada AA, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  40-  (4)  S319  -S319  1999/03
  • Fujikado T, Ohji M, Hayashi A, Okada AA, Kusaka S, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  40-  (4)  S207  -S207  1999/03
  • Saito Y, Tanaka M, Hayashi A, Kusaka S, Ohji M, Tano Y.  Invest Ophthalmol Vis Sci.(IVOS)  40-  (4)  S871  -S871  1999/03
  • Kusaka S, Dabin I, Barnstable CJ, Puro DG.  Invest Ophthalmol Vis Sci.(IVOS)  37-  (3)  665  -665  1996/02
  • 日下 俊次  あたらしい眼科  12-  103  -105  1995/12
  • 自己血清を用いた全層黄斑円孔に対する硝子体手術成績(会議録)
    忽那 実紀, 日下 俊次, 坂上 憲史, 大橋 裕一  臨床医報  89-  (7)  1019  -1019  1995/07
  • Kusaka S; Takayuki T; Tsujioka M; Kojima S; Mano T; Tsuboi S.  Invest Ophthalmol Vis Sci.(IVOS)  34-  (4)  882  -882  1993/03

Books and other publications

  • SURGICAL ANATOMY FOR OPHTHALMOLOGY
    栗原 智樹, 日下 俊次 (Contributor第5章 小児眼科・斜視手術 1小児網膜疾患の手術に必要な手術解剖)南江堂 2024/07 6 220-225
  • Pediatric Vitreoretinal Surgery
    Kusaka S. (ContributorRetinochoroidal Coloboma)Springer International Publishing 2023/06 8 451-458
  • 周産期医学53巻4号(4月増大号) How to Follow-up ―ハイリスク児フォローアップの必修知識2023
    日下 俊次 (Contributor【疾患別・領域別のフォローアップ 退院時にみられる疾患・合併症のフォローアップ】未熟児網膜症)(株)東京医学社 2023/04 4 657-660
  • Vitrectomy for retinopathy of prematurity
    Mano F, Kusaka S. (Contributor【特集】未熟児網膜症アップデート)金原出版 2023/01 6 25-30
  • ファーストステップ!子どもの視機能をみる-スクリーニングと外来診療
    岩橋 千春, 日下 俊次. (ContributorⅦ. 小児眼科のトピックス. ③未熟児網膜症に対する抗VEGF療法.)全日本病院出版会 2022/10 318 285-289
  • 西田 功一, 日下 俊次. (ContributorⅣ.他科診療にみる視機能障害 5.小児科 1)虐待による網膜病変)文光堂 2022/10 4830656166 288 270-273
  • 今日の眼疾患治療指針 第4版
    日下 俊次 (Contributorレーザーによる網膜障害)金原出版 2022/09 1184 1013-1016
  • 手術数でわかるいい病院 2022 (週刊朝日ムック)
    日下 俊次, 石田 晋 (Contributor眼の病気 網膜硝子体手術(眼の手術))朝日新聞出版 2022/06 3 362-364
  • 岡本 直之, 日下 俊次 (Supervisor)幻冬舎メディアコンサルティング,幻冬舎(発売) 2022/05 9784344930766 180
  • 日下 俊次, 石田 晋 (Contributor眼の病気 網膜硝子体手術(眼の手術))朝日新聞出版 2022/02 4022775866 528 363-364
  • 周産期の薬
    佐藤 達彦, 日下 俊次 (Contributor新生児編 疾患に対する薬剤の選び方・使い方・注意点 眼疾患 未熟児網膜症)東京医学社 2021/01 732 718-722
  • In A Quick Guide to Pediatric Retina
    Kusaka S. (Surgical Management of Stage 5 Retinopathy of Prematurity.)Springer 2021/01 302 107-111
  • 江口 洋, 野本 裕貴, 日下 俊次 (Supervisor【総論】眼科手術の近年の動向)メディカ出版 2020/08 9784840471947 302 8-9
  • 眼科学第3版
    日下 俊次, 岩橋 千春 (Contributor未熟児網膜症、鎌状網膜剥離、家族性滲出性網膜症)文光堂 2020/04 6 351-356
  • 眼疾患アトラスシリーズ4 眼病理アトラス
    歌村 翔子; 日下 俊次 (Contributor範囲: 5 網膜・ 硝子体 (1) 未熟児網膜症)総合医学社 2019/10 2 142-143
  • 眼疾患アトラスシリーズ2 後眼部アトラス
    日下 俊次 (Contributor1. 網膜 2) 網膜血管異常 (5) Coats病)総合医学社 2019/10 2 76-77
  • Retinal Detachment Surgery and Proliferative Vitreoretinopathy: From Scleral Buckling to Small Gauge Vitrectomy
    Ruiz-Casas D, Armada-Maresca F, Cabrera-López, Calzada JI, Cubero-Parra JM ,Dhawahir-Scala FE, Mostafa E, Espejo-Arjona F, Guijarro F, Fernández-Arévalo B, Fernandez-Sanz G, Garcia-Martinez J.R, Khalil GF, González-González F, Kazaykin VN, Koch P, Kusaka S, Lara-Medina FJ, Lavaque AJ, Mango CW, Marticorena S, Mura M, Nadal R, Natarajan S, Pastor-Jimeno JC, Relimpio-López MI, Tomic Z, Veckeneer M, Zarranz-Ventura J. (Vitreoretinal Surgeons Assess Surgical Cases: A Questionnaire)Springer International Publishing AG 2018/09 241-255
  • Retinal Detachment Surgery and Proliferative Vitreoretinopathy: From Scleral Buckling to Small Gauge Vitrectomy
    Ruiz-Casas D, Armada-Maresca F, Cabrera-López, Calzada JI, Cubero-Parra JM ,Dhawahir-Scala FE, Mostafa E, Espejo-Arjona F, Guijarro F, Fernández-Arévalo B, Fernandez-Sanz G, Garcia-Martinez J.R, Khalil GF, González-González F, Kazaykin VN, Koch P, Kusaka S, Lara-Medina FJ, Lavaque AJ, Mango CW, Marticorena S, Mura M, Nadal R, Natarajan S, Pastor-Jimeno JC, Relimpio-López MI, Tomic Z, Veckeneer M, Zarranz-Ventura J. (PVR Detachment Questionnaire: Part 3)Springer 2018 25 359-383
  • Retinal Detachment Surgery and Proliferative Vitreoretinopathy: From Scleral Buckling to Small Gauge Vitrectomy
    Ruiz-Casas D, Armada-Maresca F, Cabrera-López, Calzada JI, Cubero-Parra JM ,Dhawahir-Scala FE, Mostafa E, Espejo-Arjona F, Guijarro F, Fernández-Arévalo B, Fernandez-Sanz G, Garcia-Martinez J.R, Khalil GF, González-González F, Kazaykin VN, Koch P, Kusaka S, Lara-Medina FJ, Lavaque AJ, Mango CW, Marticorena S, Mura M, Nadal R, Natarajan S, Pastor-Jimeno JC, Relimpio-López MI, Tomic Z, Veckeneer M, Zarranz-Ventura J. (PVR Detachment Questionnaire: Part1)Springer 2018 8 325-332
  • 眼科インフォームドコンセント・コンセント ダウンロードして渡せる説明シート
    國吉 一樹, 日下 俊次. (未熟児網膜症.)金芳堂 2018 8 358-365
  • 未熟児網膜症
    日下 俊次, 横井 匡 (第7章 抗血管内皮増殖因子治療.)三輪書店 2018 15 150-164
  • Retinal Detachment Surgery and Proliferative Vitreoretinopathy: From Scleral Buckling to Small Gauge Vitrectomy
    Kusaka S. (PVR detachment: My surgical approach)springer 2018 5 269-273
  • Ruiz-Casas D, Armada-Maresca F, Cabrera-López, Calzada JI, Cubero-Parra JM ,Dhawahir-Scala FE, Mostafa E, Espejo-Arjona F, Guijarro F, Fernández-Arévalo B, Fernandez-Sanz G, Garcia-Martinez J.R, Khalil GF, González-González F, Kazaykin VN, Koch P, Kusaka S, Lara-Medina FJ, Lavaque AJ, Mango CW, Marticorena S, Mura M, Nadal R, Natarajan S, Pastor-Jimeno JC, Relimpio-López MI, Tomic Z, Veckeneer M, Zarranz-Ventura J. (PVR Detachment Questionnaire: Part 2)springer 2018 333-357
  • 佐藤 達彦, 日下 俊次 (ContributorⅡ治療の基礎知識 5.基本手技 ©23ゲージ硝子体手術の実際とコツ)文光堂 2017/10 4830655747 322 81
  • 未熟児網膜 症例から学ぶ 周産期診療ワークブック改訂第2版
    日下 俊次 (未熟児網膜症)メジカルビュー社 2016/07 5 471-475
  • 未熟児網膜 眼科疾患 最新の治療2016-2018
    日下 俊次 (未熟児網膜症)南江堂 2016/02 2 229-230
  • 日本医師会雑誌
    日下 俊次 (【視覚障害の早期発見と治療】小児の網膜症 未熟児網膜症・白色瞳孔)日本医学会 2015/12 4
  • 小児眼科学
    日下俊次 (網膜剥離の管理)三輪書店 2015/10 7 319-325
  • 眼科臨床エキスパート
    日下俊次 (前部増殖硝子体網膜症 網膜剥離と極小切開硝子体手術)医学書院 2015/04 109-115
  • 臨床眼科
    日下 俊次 (知っておきたい小児眼科の最新知識 重症未熟児網膜症には光凝固? それとも抗VEGF治療?(解説))医学書院 2015/02 1
  • 佐藤 達彦, 日下 俊次 (Contributor第1部 Ⅴ手術の実際 4.手術記録)文光堂 2014/01 9784830655906 x, 408p 143
  • 眼手術学 1 総論・眼窩
    佐藤 達彦, 日下 俊次 (ContributorⅤ.手術の実際 4.手術記録)文光堂 2014/01
  • 裂孔原性網膜剥離-How to treat (専門医のための眼科診療クオリファイ)
    日下 俊次 (Joint work第一次硝子体過形成遺残)中山書店 2013/06 4 217-220
  • 眼科疾患 最新の治療 2013-2015
    日下 俊次 (Joint work未熟児網膜症)南江堂 2013/06 2 213-214
  • 佐藤 達彦, 日下 俊次 (ContributorIV. 網膜硝子体手術の基本手技 I. 白内障硝子体同時手術手技)文光堂 2012/09 9784830655968 270-275
  • 佐藤 達彦, 日下 俊次 (ContributorIII.硝子体手術の器具・材料 D. 手術室 4. 手術助手)文光堂 2012/09 9784830655968 3 142-144
  • 眼手術学8 網膜・硝子体Ⅱ
    佐藤 達彦, 日下 俊次 (ContributorI.網膜剥離に対する手術 3.裂孔原性網膜剝離に対する硝子体手術 強膜圧迫法のコツ)文光堂 2012/09 44-45
  • 知りたい数値がさっと引けるぱっと分かる新生児の臨床検査・基準値ディクシ ョナリー
    日下 俊次 (眼底検査.)メディカ出版 2012/08 6 302-307
  • Workbook in perinatal and neonatal medicine, Retinoathy of Prematurity
    日下 俊次; 和田 紀久 (Joint work)メジカルビュー社 2012/07 
    周産期専門医を志望する医師を対象としたテキストで、未熟児網膜症について解説した。
  • 症例から学ぶ周産期診療ワークブック
    日下 俊次 (未熟児網膜症.)メジカルビュー社 2012/07 5 427-431
  • 眼科診療クオリファイ9 こどもの眼と疾患, 眼外傷
    日下 俊次 (Single work)中山書店 2012/02
  • 網膜硝子体手術 SOS, 低眼圧、創閉鎖不全 アドバイス
    日下 俊次 (Single work)医学書院 2012/02
  • こどもの眼と疾患
    日下 俊次. (眼外傷.眼科診療クオリファイ 9)中山書店 2012/02 5 201-205
  • 網膜硝子体手術SOS
    日下 俊次 (低眼圧、創閉鎖不全アドバイス)v 2012/02 2 228-229
  • 知りたい数値がさっと引ける ぱっと分かる 新生児の臨床検査・基準値ディクショナリー, 眼底検査
    日下 俊次 (Single work)メディカ出版 2012
  • 症例から学ぶ 周産期診療ワークブック, 未熟児網膜症
    日下 俊次 (Single work)メジカルビュー社 2012
  • 周産期医学
    日下 俊次 (未熟児網膜症に対する抗VEGF治療)東京医学社 2012
  • あたらしい眼科, 小児白内障手術 -手術のポイント-
    日下 俊次 (Single work)2012
  • 網膜硝子体手術研究会 (Contributor1. 硝子体手術の基本のセッティング 硝子体手術の正しいセットアップ)メジカルビュー社 2011/12 9784758307420 179p
  • 日下 俊次 (Contributor3.疾患別手技 未熟児網膜)メジカルビュー社 2011/11 4758307423 179 160-167
  • 日下 俊次 (Contributor2.基本手技 バックルの併用)メジカルビュー社 2011/11 4758307423 179 80-85
  • 日下 俊次 (Contributor2.基本手技 冷凍凝固)メジカルビュー社 2011/11 4758307423 179 76-79
  • 日下 俊次 (Contributor1.硝子体手術の基本セッティング 硝子体手術の正しいセットアップ)メジカルビュー社 2011/11 4758307423 179 18-23
  • 日下 俊次 (Contributor1.硝子体手術の基本セッティング 硝子体手術の機会器具(20G))メジカルビュー社 2011/11 4758307423 179 10-17
  • 専門医のための眼科診療クオリファイ 8網膜血管障害
    日下 俊次 (Contributor7発達障害 未熟児網膜症)中山書店 2011/10 210-215
  • 日下 俊次 (ContributorⅢ新しい手術器械, 手技)メジカルビュー社 2011/01 4758310793 217 168-169
  • 佐藤 達彦, 日下 俊次 (ContributorⅡ疾患別 私はこうするバックル手術後の再剥離症例の治療)メジカルビュー社 2010/10 9784758310789 165p 106-113
  • 網膜剥離こうすれば治る復位率100%をめざして
    佐藤 達彦, 日下 俊次. (パックル手術後の再剥離症例の治療.)メディカルビュー社 2010/10 8 106-113
  • 佐藤 達彦, 日下 俊次 (ContributorⅦ. 手術法の選択. 14.未熟児網膜症)文光堂 2009/11 9784830655876 327p 306-308
  • 佐藤 達彦, 日下 俊次 (ContributorⅦ. 手術法の選択. 4.小児網膜剥離.)文光堂 2009/11 9784830655876 327p 276-277
  • 佐藤 達彦, 日下 俊次 (Contributor小切開硝子体手術 23Gの器具バイヤーズガイド)メジカルビュー社 2009/07 9784758307369 217p 182-187
  • 佐藤 達彦, 日下 俊次 (ContributorⅤ.手術用薬の使い方 1.消毒薬)文光堂 2008/09 4830655801 673 404-405
  • 日下 俊次 (ContributorIV.23G硝子体手術の操作 増殖膜処理)メジカルビュー社 2008/03 9784758307314 199p 88-91
  • 日下 俊次 (ContributorIV. 23G硝子体手術の操作 後部硝子体膜剥離)メジカルビュー社 2008/03 9784758307314 199p 80-83
  • 佐藤 達彦, 日下 俊次 (ContributorIV. 23G硝子体手術の操作 硝子体切除)メジカルビュー社 2008/03 9784758307314 199p 76-79
  • 眼科手術21
    日下 俊次 (Contributorワイドビューイング硝子体手術-非接触型)日本眼科手術学会誌 2008/01 2
  • 佐藤 達彦, 日下 俊次 (ContributorⅢ.眼科診療における硝子体 7)小児白内障手術の適応と実際)文光堂 2007/10 4830655747 322 122-125
  • 日下 俊次, 佐藤 達彦 (ContributorⅢ.眼科診療における硝子体 4.小児眼科と硝子体 ©若年網膜剥離手術の手術適応-バックルか硝子体手術か-)文光堂 2007/10 4830655747 322 190-191
  • 佐藤 達彦, 日下 俊次 (ContributorⅢ.眼科診療における硝子体 4.小児眼科と硝子体 2)小児の硝子体手術)文光堂 2007/10 4830655747 322 186-189
  • 佐藤 達彦 , 日下 俊次 (Contributor光凝固を施行しても網膜剥離を併発する重症未熟児網膜症に対して,時期を逃さず早期に硝子体手術を施行しよう)メジカルビュー社 2007/07 4758307229 179 144-147
  • 眼科インストラクションコース11 眼科ERまるごとマスター : 緊急性から考えようエマージェンシー
    中田 亙, 日下 俊次 (Contributorさあ どうする?~網膜硝子体手術後の診察室にて)メジカルビュー社 2007/04 185 160-171
  • 佐藤 達彦, 日下 俊次 (ContributorⅢ.疾患アトラス 1.眼循環異常 13)未熟児網膜症)文光堂 2006/12 4830655690 371 163-164
  • 佐藤 達彦,日下 俊次 (ContributorⅢ.疾患アトラス 1.眼循環異常 2)Coats病)文光堂 2006/12 4830655690 371 110-111
  • 日下 俊次 (ContributorⅢ網膜・硝子体 硝子体)南江堂 2006/10 4524240977 115-123
  • 佐藤 達彦, 日下 俊次 (ContributorⅣ.書類の書き方 3.診断書)文光堂 2006/08 4830655674 332 194-196
  • 坂口 裕和, 日下 俊次 (Contributor2. 観察方法 3) 特殊眼底検査 ③術中眼底検査)文光堂 2005/09 4830655615 365 129
  • 中田 亙, 日下 俊次 (ContributorⅢ網膜硝子体所見の捉え方と描き方 2.観察法 3)特殊眼底検査 ②未熟児の眼底検査 ・外傷眼と術後早期の眼底観察)文光堂 2005/09 4830655615 365 126-127
  • 中田 亙, 日下 俊次 (ContributorⅢ網膜硝子体所見の捉え方と描き方 2.観察法 3)特殊眼底検査 ②未熟児の眼底検査 ・ガスタンポナーデ眼の眼底検査)文光堂 2005/09 4830655615 365 128
  • 日下 俊次 (ContributorⅢ網膜硝子体所見の捉え方と描き方 2.観察法 3)特殊眼底検査 ②未熟児の眼底検査 ・BIOMによる小瞳孔例の硝子体手術)文光堂 2005/09 4830655615 365 124-125
  • 坂口 裕和, 日下 俊次. (III. 網膜硝子体所見の捉え方と描き方 2. 観察方法 (3) 術中眼底検査)文光堂 2005/09 4830655615 365 129-133
  • 中田 亙, 日下 俊次. (ContributorIII. 網膜硝子体所見の捉え方と描き方 2. 観察方法 3) 特殊眼底検査 ガスタンポナーデ眼の眼底検査)文光堂 2005/09 4830655615 365 128
  • 中田亙, 日下俊次 (ContributorIII. 網膜硝子体所見の捉え方と描き方 3) 特殊眼底検査 (2) 未熟児の眼底検査 外傷眼と術後早期の眼底観察)文光堂 2005/09 4830655615 365 126-127
  • 日下 俊次. (ContributorIII. 網膜硝子体所見の捉え方と描き方 2. 観察方法 3) 特殊眼底検査 (2) 未熟児の眼底検査 BIOMによる小瞳孔例の硝子体手術)文光堂 2005/09 4830655615 365 124-125
  • 下條 裕史, 日下 俊次. (ContributorIII. 網膜硝子体所見の捉え方と描き方 2. 観察方法3) 特殊眼底検査(2) 未熟児の眼底検査)文光堂 2005/09 4830655615 365 122-123
  • 下條 裕史, 日下 俊次. (ContributorIII. 網膜硝子体所見の捉え方と描き方 2. 観察方法3) 特殊眼底検査(1) 小児の眼底検査)文光堂 2005/09 4830655615 365 120-121
  • 日下 俊次 (ContributorⅦ黄斑病変の手術治療 T内境界膜と染色の安全性)文光堂 2005/04 4830655593 326 265
  • NANO OPHTHALMOLOGY30
    日下 俊次 (Contributor〔特集〕小児眼科のトピックス 小児の網膜剥離)ロートニッテン 2005 14-18

Lectures, oral presentations, etc.

  • Retinal Detachment associated with CXLRS and Coats ds  [Invited]
    Kusaka S
    EURETINA 2024  2024/09  Barcelona, Spain  European Society of Retina Specialists
  • Surgery for Complications of the Coats’ Disease
    Kusaka S.
    WOC2024  2024/08  Vancouver, Canada  International Council of Ophthalmology
  • Skills Transfer Course - Advanced Vitrectomy
    Kusaka S.
    WOC2024  2024/08  Vancouver, Canada  International Council of Ophthalmology
     
    Course instructor
  • Skills Transfer Course - Basic Vitrectomy
    Kusaka S.
    WOC2024  2024/08  Vancouver, Canada  International Council of Ophthalmology
     
    Course instructor
  • Anti-VEGF in ROP: comparison and efficacy
    Kusaka S.
    6th RETINA SUMMIT 2024 & 8th iROP ANNUAL MEETING  2024/07  Chennai, India  The Team Retina Summit 2024
  • 【Panel Discussion】Session 5 : Surgical Session - PART 2
    Kusaka S, Gopal L, R Azad, Dogra MR, Chandra P, Singh SR.
    6th RETINA SUMMIT 2024 & 8th iROP ANNUAL MEETING  2024/07  Chennai, India  The Team Retina Summit 2024
  • ROP mimickers and masqueraders
    Kusaka S.
    6th RETINA SUMMIT 2024 & 8th iROP ANNUAL MEETING  2024/07  Chennai, India  The Team Retina Summit 2024
  • 視神経乳頭肉芽腫を伴う眼サルコイドーシスの一例
    中尾 力登, 岩橋 千春, 坂本 万寿夫, 日下 俊次.
    第57回日本眼炎症学会(眼感染・炎症・アレルギー学会2024in札幌)  2024/07  札幌市, グランドメルキュール札幌大通公園(旧:ロイトン札幌)  第60回日本眼感染症学会 会長:鈴木 崇(東邦大学医療センター大森病院眼科/ いしづち眼科)第57回日本眼炎症学会 会長:南場 研一(北海道大学大学院医学研究院眼科学教室)第7回日本眼科アレルギー学会 会長:南場 研一(北海道大学大学院医学研究院眼科学教室)
  • COVID-19ワクチン接種後に発症したサルコイドーシスの1例
    新名 愛, 坂本 万寿夫, 堂本 綾, 岩橋 千春, 日下 俊次
    第57回日本眼炎症学会(眼感染・炎症・アレルギー学会2024in札幌)  2024/07  札幌市, グランドメルキュール札幌大通公園(旧:ロイトン札幌)  第60回日本眼感染症学会 会長:鈴木 崇(東邦大学医療センター大森病院眼科/ いしづち眼科) 第57回日本眼炎症学会 会長:南場 研一(北海道大学大学院医学研究院眼科学教室 第7回日本眼科アレルギー学会 会長:南場 研一(北海道大学大学院医学研究院眼科学教室)
  • 髄膜炎菌による角膜穿孔例
    田口 縁, 江口 洋, 堀田 芙美香, 日下 俊次, 宮本 龍郎.
    第60回日本眼感染症学会(眼感染・炎症・アレルギー学会2024in札幌)  2024/07  札幌市, グランドメルキュール札幌大通公園(旧:ロイトン札幌)  第60回日本眼感染症学会 会長:鈴木 崇(東邦大学医療センター大森病院眼科/ いしづち眼科) 第57回日本眼炎症学会 会長:南場 研一(北海道大学大学院医学研究院眼科学教室 第7回日本眼科アレルギー学会 会長:南場 研一(北海道大学大学院医学研究院眼科学教室)
  • 10+ years of clinical experience with EVA surgical system
    Kusaka S.
    TDC VELOCETM Launch Event  2024/07  Chiyoda-ku, The Tokyo Station Hotel  DORC/アールイーメディカル
  • 10+ years of clinical experience with EVA surgical system
    Kusaka S.
    TDC VELOCETM Launch Event  2024/07  大阪市, グランフロント大阪  DORC/アールイーメディカル
  • 小児網膜疾患に対する外科的治療の進歩
    Kusaka S.
    第25回愛知眼科アカデミー  2024/06  名古屋市, 名古屋観光ホテル  興和株式会社
  • 間欠性外斜視の眼位コントロールに対する交代遮閉法の有用性
    竹澤 優子, 白石 ゆかり, 成田 郁美, 若山 暁美, 七部 史, 日下 俊次.
    第80回日本弱視斜視学会総会/第49回日本小児眼科学会総会合同学会  2024/06  浜松市, アクトシティ浜松  利明(国際医療福祉大学熱海病院)/第49回日本小児眼科学会総会会長 近藤 峰生(三重大学大学院医学系研究科臨床医学系講座眼科学)
  • Peripheral Retinal Nonperfusion in Morning Glory Syndrome
    Kurihara T, Fukushima M, Kuniyoshi K, Kusaka S.
    第80回日本弱視斜視学会総会/第49回日本小児眼科学会総会合同学会  2024/06  浜松市, アクトシティ浜松  学会総会会長 後関 利明(国際医療福祉大学熱海病院)/第49回日本小児眼科学会総会会長 近藤 峰生(三重大学大学院医学系研究科臨床医学系講座眼科学)
  • 腎機能障害に先行して発症したNPHP1関連網膜ジストロフィ
    堂本 綾, 國吉 一樹, 須賀 晶子, 吉武 和敏, 河合 洋介, 大前 陽輔, 徳永 勝士, 岩田 岳, 日下 俊次.
    第80回日本弱視斜視学会総会/第49回日本小児眼科学会総会合同学会  2024/06  浜松市, アクトシティ浜松  第80回日本弱視斜視学会総会会長 後関 利明(国際医療福祉大学熱海病院)/第49回日本小児眼科学会総会会長 近藤 峰生(三重大学大学院医学系研究科臨床医学系講座眼科学)
  • 心因性視覚障害と詐病のimoによる静的視野検査における偽陰性応答
    杉野 日彦, 松本 長太, 七部 史, 野本 裕貴, 日下 俊次.
    第13回日本視野画像学会学術集会  2024/06  新潟市, 朱鷺メッセ 新潟コンベンションセンター  新潟大学大学院医歯学総合研究科 眼科学分野
  • 遺伝性網膜ジストロフィにおける遺伝子異常と視野異常
    新名 愛, 國吉 一樹, 林 孝彰, 岩田 岳, 西口 康二, 角田 和繁, 溝渕 圭, 須賀 晶子, 吉武 和敏, 後藤 健介, 川島 弘彦, 藤波 芳, 中野 匡, 松本 長太, 日下 俊次.
    第13回日本視野画像学会学術集会  2024/06  新潟市, 朱鷺メッセ 新潟コンベンションセンター  新潟大学大学院医歯学総合研究科 眼科学分野
  • チラブルチニブ投与後2年経過観察を行った網膜硝子体リンパ腫併発再発性中枢神経系原発 悪性リンパ腫の1例
    坂本 万寿夫, 岩橋 千春, 日下 俊次.
    第460回大阪眼科集談会プログラム  2024/06  大阪市, 毎日新聞オーバルホール  一般社団法人大阪府眼科医会
  • 〔特別講演〕未熟児網膜症診療の現状と課題
    日下 俊次
    第3回ゐのはなNetwork  2024/05  千葉市, 京成ホテルミラマーレ  千寿製薬株式会社
  • PEDIATRIC RETINA: CASE PRESENTATIONS AND PANEL DISCUSSION
    Kusaka S, Kychenthal A, Moshfeghi DM, Özdek Ş, Riazi M, Teixeira SM.
    Retina World Congress 2024 Meeting  2024/05  Fort Lauderdale, USA  Healio LIVE
  • Evaluation of reliable indices glaucomatous visual field.
    Nomoto H, Matsumoto C, Okuyama S, Tanabe F, Kimura T, Yoshikawa K, Mizoue S, Nanno M, Kimura S, Inoue S, Kusaka S.
    The 128th Annual Meeting of the Japanese Ophthalmological Society  2024/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • A case of aAION in a patient with EGPA
    Domoto A, Iwahashi C, Kuniyoshi K, Kusaka S.
    The 128th Annual Meeting of the Japanese Ophthalmological Society  2024/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • The effect of PAI-1 on corneal fibroblast transformation by TGF-β
    Yunoki M, Sugioka K, Nishida T, Murakami J, Kida T, Fukuda M, Kusaka S.
    The 128th Annual Meeting of the Japanese Ophthalmological Society  2024/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • Long-read genome sequencing on Japanese siblings with blue-cone monochromatism
    Kuniyoshi K, Hayashi T, Suga A, Mizobuchi K, Yoshitake K, Tachibana K, Domoto A, Kawai Y, Omae Y, Tokunaga K, Nakano T, Iwata T, Kusaka S.
    The 128th Annual Meeting of the Japanese Ophthalmological Society  2024/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • 【特別講演Ⅱ】難治性網膜硝子体疾患に対する硝子体手術
    日下 俊次.
    第97回香川大学眼科研究会  2024/04  高松市, 高松国際ホテル 2階 「讃岐の間」  香川大学眼科研究会・参天製薬株式会社
  • 〔Scientific Paper Session (Surgical) 6 P:Pediatrics〕 Long‐term functional results following vitrectomy for stage 4A ROP
    Kusaka S.
    FUJI RETINA 2024  2024/03  Toranomon Hills, Minato-ku, Tokyo  鹿児島大学
  • 〔Case Conference 2〕Surgical treatment for CXLRS
    Kusaka S.
    FUJI RETINA 2024  2024/03  Toranomon Hills Forum, Minato-ku, Tokyo  鹿児島大学
  • Long-term functional results following vitrectomy for stage 4A ROP
    Kusaka S.
    2024 Taiwan Macula Society Spring Meeting  2024/03  Kaohsiung City, Taiwan  TMS Taiwan Macula Society
  • Surgical treatment for CXLRS
    Kusaka S.
    Taiwan Macular Society Meeging  2024/03  Kaohsiung City, Taiwan  TMS Taiwan Macula Society
  • How do I do it
    Mohammad A, Kusaka S, Waheb S, Fayyad F, Romano M, Mahmoud T, Hassan A, Godziridis S, Aldibi H.
    SRS2024  2024/03  Riyadh, Saudi Arabia  Saudi Retina Group
  • Surgical treatment for severe Coats disease ー AWhen and how?
    Kusaka S.
    SRS2024  2024/03  Riyadh, Saudi Arabia  Saudi Retina Group
  • Vitrectomy for eyes with retinal detachment associated with morning glory syndrome
    Kusaka S.
    SRS2024  2024/03  Riyadh, Saudi Arabia  Saudi Retina Group
  • Surgery for stage 4 ROP: indications, timing, technique, long term results
    Kusaka S.
    SRS2024  2024/03  Riyadh, Saudi Arabia  Saudi Retina Group
  • Tips and Tricks in Vitrectomy for myopic traction maculopathy
    Kusaka S.
    SRS2024  2024/03  Riyadh, Saudi Arabia  Saudi Retina Group
  • Visual Field Test for Glaucoma Patients by Imo Vifa Perimetry
    Nomoto H, Matsumoto C, Iwase A, Minamino A, Tanabe F, Kusaka S.
    APAO2024  2024/02  Bali, Indonesia  Asia-Pacific Academy of Ophthalmology
  • 総会長企画3 コールドケース外伝 in 手術学会
    門之園 一明, 瓶井 資弘, 日下 俊次, 森實 佑基, 本田 茂, 大澤 俊介, 栗山 晶治
    第47回日本眼科手術学会学術総会  2024/02  国立京都国際会館, 京都市  日本眼科手術学会
  • 抗VEGF薬が奏功した網膜静脈分枝閉塞症を伴う視神経乳頭近傍の網膜細動脈瘤の1例
    中尾 力登, 岩橋 千春, 坂本 万寿夫, 國吉 一樹, 日下 俊次.
    第458回大阪眼科集談会  2024/02  大阪市, 毎日新聞オーバルホール  一般社団法人大阪府眼科医会
  • 全ゲノム解析により診断されたNPHP1関連網膜症
    堂本 綾, 國吉 一樹, 角田 和繁, 須賀 晶子, 吉武 和敏, 河合 洋介, 大前 陽輔, 徳永 勝士, 川島 弘彦, 藤波 芳, 岩田 岳, 日下 俊次.
    第70回日本臨床視覚電気生理学会  2024/02  北九州市, 北九州国際会議場  産業医科大学眼科学教室
  • 【特別講演Ⅱ】未熟児網膜症に対する外科的治療
    日下 俊次
    第31回兵庫県黄斑疾患研究会  2024/01  神戸市, ANAクラウンプラザホテル神戸  バイエル薬品株式会社・参天製薬株式会社
  • 【Pediatric Retina (1)】 Complicated Pediatric RD in XLRS and MGS
    Kusaka S.
    16th APVRS Congress  2023/12  Wan Chai, Hong Kong  Asia-Pacific Vitreo-retina Society
  • 小児網膜硝子体疾患の外科的治療
    日下 俊次
    Orange Eye Surgical Seminar  2023/12  松山市, 松山市医師会館  日本アルコン株式会社
  • 後部硝子体剥離が発症に関与しない黄斑円孔の特徴.
    赤井 亮太, 福島 正樹, 加藤 剛, 林 篤志, 日下 俊次, 瓶井 資弘, 坪井 孝太郎.
    The 62nd Annual Meeting of Japanese Retina and Vitreous Society  2023/11  横浜市, パシフィコ横浜ノース  第62回日本網膜硝子体学会総会
  • [学術展示] 抗VEGF薬が奏効した網膜分枝静脈閉塞症を伴う 視神経乳頭近傍の網膜細動脈癌の1例.
    中尾 力登, 岩橋 千春, 坂本 万寿夫, 國吉 一樹, 日下 俊次.
    The 62nd Annual Meeting of Japanese Retina and Vitreous Society  2023/11  横浜市, パシフィコ横浜ノース  横浜市立大学 大学院医学研究科 視覚再生外科学教室
  • [学術展示]Perfluoro-n-octane (PFO) tamponade for penetrating keratoplasty and vitrectomy.
    Kurihara T, Hotta F, Eguchi H, Kusaka S.
    The 62nd Annual Meeting of Japanese Retina and Vitreous Society  2023/11  横浜市, パシフィコ横浜ノース  横浜市立大学 大学院医学研究科 視覚再生外科学教室
  • [優秀演題シンポジウム2]Embedding versus removal for macular holes with epiretinal proliferation.
    Fukushima M, Hayashi A, Kusaka S, Kamei M, Wakabayashi T, Tsuboi K.
    The 62nd Annual Meeting of Japanese Retina and Vitreous Society  2023/11  横浜市, パシフィコ横浜ノース  横浜市立大学 大学院医学研究科 視覚再生外科学教室
  • 網膜芽細胞腫硝子体術後に高眼圧をきたした一例.
    新名 愛, 野本 裕貴, 日下 俊次.
    第63回PACGs  2023/11  大阪市(Web開催)
  • A Japanese family with Stickler syndrome
    Domoto A, Kuniyoshi K, Kondo H, Matsushita I, Iimori H, Eura M, Kusaka S.
    The 77th Annual of Japanese Clinical Ophthalmology  2023/10  千代田区, 東京国際フォーラム・JPタワーホール&カンファレンス  筑波大学医学医療系眼科
  • 網膜剥離ファイトクラブ round 19 -症例をシェアして自分のものにする-
    喜多 美穂里, 大島 佑介, 門之園 一明, 木村 英也, 日下 俊次, 栗山 晶治, 竹内 忍
    The 77th Annual of Japanese Clinical Ophthalmology  2023/10  千代田区, 東京国際フォーラム・JPタワーホール&カンファレンス  筑波大学医学医療系眼科
  • Frequency and clinical features of syndromic FEVR with gene mutations
    Asano M, Naruse S, Matsushita I, Kawamura T, Hayashi T, Uchio E, Kusaka S, Kondo H
    The 77th Annual of Japanese Clinical Ophthalmology  2023/10  千代田区, 東京国際フォーラム・JPタワーホール&カンファレンス  筑波大学医学医療系眼科
  • Comparison of epiretinal proliferation observed by OCT and intraoperatively
    Fukushima M, Hayashi A, Kusaka S, Kamei M, Tsuboi K.
    The 77th Annual of Japanese Clinical Ophthalmology  2023/10  千代田区, 東京国際フォーラム・JPタワーホール&カンファレンス  筑波大学医学医療系眼科
  • Detection of retinal slow perfusion area by interscan time variable OCTA in CRVO
    Mano F, Sato T, Kuniyoshi K, Kusaka S.
    The 77th Annual of Japanese Clinical Ophthalmology  2023/10  千代田区, 東京国際フォーラム・JPタワーホール&カンファレンス  筑波大学医学医療系眼科
  • Comparison between the new and old central CFF-meter
    Sugino A, Matsumoto C, Kayazawa T, Tanabe F, Nomoto H, Kusaka S
    The 77th Annual of Japanese Clinical Ophthalmology  2023/10  千代田区, 東京国際フォーラム・JPタワーホール&カンファレンス  筑波大学医学医療系眼科
  • 〔Instructional Course 34: Paediatric Retina: Complications and Challenges〕Surgical challenges in paediatric retinal detachment (including Coats disease, atopic dermatitis, CXLRS and others)
    Kusaka S.
    23rd EURETINA Congress  2023/10  Amdterdam, Netherlands  European Society of Retina Specialists
  • Kadayifcilar S, Durukan H, Akkoyun I, Sayin N, Celik G, Teixeira S, Kusaka S.
    TOA Retinopathy of Prematurity Commission Skill Transfer Course  2023/09  Ankara, Turkey  Turkish Ophthalmological Association
  • Özdek Ş, Jalali S, Kusaka S, Harper CA 3rd, Teixeira S.
    TOA Retinopathy of Prematurity Commission Skill Transfer Course  2023/09  Ankara, Turkey  Turkish Ophthalmological Association
  • Differential diagnosis: (FEVR, Norrie, Incontinentia Pigmenti, PFV, Coats)
    Kusaka S,
    TOA Retinopathy of Prematurity Commission Skill Transfer Course  2023/09  Ankara, Turkey  Turkish Ophthalmological Association
  • Kusaka S
    TOA Retinopathy of Prematurity Commission Skill Transfer Course  2023/09  Ankara, Turkey  Turkish Ophthalmological Association
  • Kusaka S.
    TOA Retinopathy of Prematurity Commission Skill Transfer Course  2023/09  Ankara, Turkey  Turkish Ophthalmological Association
  • Kusaka S.
    TOA Retinopathy of Prematurity Commission Skill Transfer Course  2023/09  Ankara, Turkey  Turkish Ophthalmological Association
  • タブレット端末を用いたMulti-Stimulus vision tester (MVT) におけるタッチ応答の検討
    七部 史, 松本 長太, 石橋 眞里佳, 杉野 日彦, 野本 裕貴, 日下 俊次, 岩瀬 愛子.
    第34回日本緑内障学会  2023/09  港区, 虎ノ門ヒルズフォーラム  東京慈恵会医科大学 眼科学講座
  • Surgical treatment of traction retinal detachments associated with compound heterozygous congenital protein C deficiency
    Kurihara T, Endo T, Obata S, Hotta T, Nishio N, Iwaibara T, Hirata K, Kuge S, Konishi Y, Yoshida D, Yanagi T, Taga T, Wada K, Wada N, Ohga S, Kusaka S.
    Advances in Pediatric Retina 2023  2023/09  Santa Clara, USA  iVista Medical Education, Inc.
     
    学会開催期間中(2023.9.7-2023.9.9)会場でループ放映
  • Retinal detachment in kids
    Kusaka S.
    APR 2023  2023/09  Santa Clara, USA  iVista Medical Education, Inc.
  • Long-term visual outcomes after vitrectomy for stage 4A retinopathy of prematurity
    Kusaka S
    Osaka Retina Meeting 2023  2023/09  大阪市, グランフロント大阪  大阪網膜硝子体研究会
  • Vitrectomy for retinal arterial occlusiin
    Kusaka S.
    Osaka Retina Meeting 2023  2023/09  大阪市, グランフロント大阪  大阪網膜硝子体研究会
  • Coats病に対する硝子体手術後の合併症
    日下 俊次
    Japan Macula Club 2023 第23回学術講演会  2023/08  蒲郡市, 蒲郡クラシックホテル  Japan Macula Club, 株式会社ニデック, 参天製薬株式会社
  • Association Between Epiretinal Proliferation Observed on OCT vs Intraoperative Observation with Brilliant Blue G in Eyes with Macular Hole
    Fukushima M, Tsuboi K, Kusaka S, Kamei M, Hayashi A.
    American Society of Retina Specialists Annual Meeting 2023(ASRS 2023)  2023/07  Seattle, USA  AMERICAN SOCIETY OF RETINA SPECIALISTS
  • COVID-19 ワクチン接種後に網脈絡膜循環障害を呈した 1 例
    大賀 智行, 岩橋 千春, 坂本 万寿夫, 國吉 一樹, 日下 俊次.
    第39回日本眼循環学会  2023/07  奈良市, 奈良県コンベンションセンター  奈良県立医科大学眼科学教室
  • Characteristics of RAP in Early Stage by using OCTA
    Sato T, Mano F, Kuniyoshi K, Kusaka S.
    第39回日本眼循環学会  2023/07  奈良市, 奈良県コンベンションセンター  奈良県立医科大学眼科学教室
  • コンタクトレンズ装用者に生じた角膜脂肪変性の3例
    Takahashi A, Fukuda M, Tsukiyama J, Miyamoto Y, Ito E, Yunoki M, Nishida K, Sugioka K, Kusaka S.
    第65回日本コンタクトレンズ学会総会  2023/07  大阪市, 大阪国際会議場  第59回日本眼感染症学会・第56回日本眼炎症学会・第65回日本コンタクトレンズ学会総会・第11回日本涙道・涙液学会総会第
  • 急性前部ぶどう膜炎と内因性眼内炎の診断における全身性炎症性反応マーカーの有用性.
    Iwahashi C, Sakamoto M, Kusaka S.
    第56回日本眼炎症学会(フォーサム2023大阪)  2023/07  大阪市, 大阪国際会議場  第59回日本眼感染症学会・第56回日本眼炎症学会・第65回日本コンタクトレンズ学会総会・第11回日本涙道・涙液学会総会
  • 離島在住の超高齢者に発症したTrichocladium uniseriatum角膜炎
    Domoto A, Eguchi H, Hotta F, Yaguchi T, Kusaka S.
    第59回日本眼感染症学会  2023/07  大阪市, 大阪国際会議場  第56回日本眼感染症学会(フォーサム2023大阪) 2023年7月8日 第59回日本眼感染症学会・第56回日本眼炎症学会・第65回日本コンタクトレンズ学会総会・第11回日本涙道・涙液学会総会
  • 口腔内常在菌叢の微生物による感染性角膜炎を繰り返した症例の研究
    Goto Y, Eguchi H, Hotta F, Kusaka S, Miyamoto T.
    第56回日本眼感染症学会(フォーサム2023大阪)  2023/07  大阪市, 大阪国際会議場  第59回日本眼感染症学会・第56回日本眼炎症学会・第65回日本コンタクトレンズ学会総会・第11回日本涙道・涙液学会総会
  • COVID-19関連原田病の3例
    坂本 万寿夫, 田村 佳菜子, 大賀 智行, 岩橋 千春, 日下 俊次.
    第56回日本眼炎症学会(フォーサム2023大阪)  2023/07  大阪市, 大阪国際会議場  第59回日本眼感染症学会・第56回日本眼炎症学会・第65回日本コンタクトレンズ学会総会・第11回日本涙道・涙液学会総会
  • STEP BY STEP VITRECTOMY (HOW TO SET UP SURGERY)
    Kusaka S.
    12th Thessaloniki Vitreo-Retinal Summer School (TVRS)  2023/07  Thessaloniki, Greece  MEDITERRETINA SOCIETY
  • VITRECTOMY FOR RRD
    Kusaka S.
    12th Thessaloniki Vitreo-Retinal Summer School (TVRS)  2023/07  Thessaloniki, Greece  MEDITERRETINA SOCIETY
  • 【KEYNOTE-4】 Current Concepts in pediatric macular surgeries.
    Kusaka S.
    RETINA SUMMIT MACULAR SURGERY  2023/07  Chennai, India  Sankara Nethralaya
  • Tips and Tricks in Vitrectomy for myopic traction maculopathy
    Kusaka S.
    RETINA SUMMIT MACULAR SURGERY  2023/06  Chennai, India  Sankara Nethralaya
  • パネルディスカッションⅡ「合併症」
    日下 俊次
    第22回硝子体手術ビデオセミナー  2023/06  品川区, 東京コンファレンスセンター  網膜硝子体手術研究会
  • セッションⅡ網膜剥離「硝子体手術」
    日下 俊次
    第22回硝子体手術ビデオセミナー 硝子体手術達人への道  2023/06  品川区, 東京コンファレンスセンター  網膜硝子体手術研究会
  • 両眼開放視野計を用いた周辺視野における両眼立体視閾値の評価
    若山 暁美, 松本 長太, 歌村 圭介, 成田 竜, 日下 俊次.
    第79回日本弱視斜視学会総会(JASA)/第48回日本小児眼科学会総会(JAPO)合同学会  2023/06  仙台市, 仙台国際センター  福島県立医科大学眼科学講座
  • 接触式広角眼底カメラ3機種の比較
    堂本 綾, 栗原 智樹, 眞野 福太郎, 岩橋 千春, 國吉 一樹, 日下 俊次.
    第79回日本弱視斜視学会総会(JASA)/第48回日本小児眼科学会総会(JAPO)合同学会 2023年6月16日 福島県立医科大学眼科学講座  2023/06  仙台市, 仙台国際センター  福島県立医科大学眼科学講座
  • 未熟児網膜症(ROP)に対する網膜光凝固術後の滲出性網膜剝離の1例
    栗原 智樹, 西村 香澄, 土屋 陽子, 児玉 洋平, 田中 藍, 日下 俊次.
    第79回日本弱視斜視学会総会(JASA)/第48回日本小児眼科学会総会(JAPO)合同学会  2023/06  仙台市, 仙台国際センター  福島県立医科大学眼科学講座
     
    学術展示2023.6.16-2023.6.17
  • 小児用接触式広角眼底カメラ3機種の比較
    堂本 綾, 栗原 智樹, 眞野 福太郎, 岩橋 千春, 國吉 一樹, 日下 俊次.
    第454回大阪眼科集談会  2023/06  大阪市, 毎日新聞オーバルホール  一般社団法人大阪府眼科医会
  • 両眼開放視野計を用いた両眼立体視閾値測定法の開発.
    若山 曉美, 松本 長太, 歌村 圭介, 成田 竜, 日下 俊次.
    第12回日本視野画像学会学術集会  2023/05  名古屋市, ウインクあいち  日本視野画像学会
  • 梅毒脈絡網膜炎の4例.
    大賀 智行, 國吉 一樹, 山雄 さやか, 岩橋 千春, 坂本 万寿夫, 中嶌 彩夏, 松本 長太, 日下 俊次.
    第12回日本視野画像学会学術集会  2023/05  名古屋市, ウインクあいち  日本視野画像学会
  • MVTを用いた視野スクリーニング検査における年齢の影響.
    七部 史, 松本 長太, 石橋 眞里佳, 野本 裕貴, 日下 俊次, 岩瀬 愛子.
    第12回日本視野画像学会学術集会  2023/05  名古屋市, ウインクあいち  日本視野画像学会
  • Current Concept and Treatment of Retinopathy of Prematurity.
    Kusaka S.
    Okinawa Retina Summit  2023/05  Okinawa, Japan  バイエル薬品株式会社・参天製薬株式会社
  • Cone dystrophy with normal funduscopic appearance
    Kuniyoshi K, Tsunoda K, Hayashi T, Nagae Y, Fujinami K, Suga A, Iwata T, Kusaka S.
    The 127th Annual Meeting of the Japanese Ophthalmological Society  2023/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • 【ランチョンセミナー30 極 網膜硝子体手術のTips and Tricks】エキスパートが行う最新の網膜硝子体疾患の手術
    日下 俊次
    第127回日本眼科学会総会  2023/04  千代田区, 東京国際フォーラム  第127回日本眼科学会総会/ライカマイクロシステムズ株式会社
  • Role of uPA,Endo180 and uPAR on alpha‐SMA expression in corneal myofibroblasts
    Sugioka K, Nishida T, Takahashi A, Murakami J, Mano F, Fukuda M, Kusaka S.
    The 127th Annual Meeting of the Japanese Ophthalmological Society  2023/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • Alpha2‐antiplasmin regulates alpha‐SMA expression in corneal fibroblasts
    Yunoki M, Sugioka K, Nishida T, Murakami J, Kida T, Fukuda M, Kusaka S.
    The 127th Annual Meeting of the Japanese Ophthalmological Society  2023/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • Detection of retina slow perfusion area by inter-scan time variable OCTA in CRVO
    Mano F, Sato T, Kuniyoshi K, Kusaka S.
    The 127th Annual Meeting of the Japanese Ophthalmological Society  2023/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • Long-term visual results of eyes following vitrectomy for stage 4A ROP.
    Iwahashi C, Tachibana K, Kurihara T, Kusaka S.
    The 127th Annual Meeting of the Japanese Ophthalmological Society  2023/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • Trends in the number of infants treated for familial exudative vitreoretinopathy
    Ochiai N, Watanabe F, Ohnishi M, Tokutsu K, Kaneko Y, Kawasaki R, Kusaka S, Nishina S, Matsuda S, Fushimi K, Kondo H.
    The 127th Annual Meeting of the Japanese Ophthalmological Society  2023/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • Development of a new MVT-based metamorpho‐psia detective tool
    Tanabe F, Matsumoto C, Nomoto H, Koike E, Kusaka S, Yamao S.
    The 127th Annual Meeting of the Japanese Ophthalmological Society  2023/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • MVT(Multi-Stimulus vision tester)を用いた新しい変視定量ツール
    七部 史, 松本 長太, 野本 裕貴, 日下 俊次, 小池 英子, 山雄 さやか.
    第453回大阪府眼科集談会プログラム  2023/04  大阪市, 毎日新聞オーバルホール  一般社団法人大阪府眼科医会
  • Pars plana vitrectomy for vitreoretinal complications in only seeing eyes after treatment for retinoblastoma
    Kusaka S.
    FUJI RETINA  2023/03  Toranomon Hills, Minato-ku, Tokyo  JRVS (Japan Retina and Vitreous Society)
  • Longitudinal clinical course of two siblings with KCNV2-associated retinopathy
    Sato T, Kuniyoshi K, Hayashi T, Nishiwaki H, Hatsukawa Y, Mizobuchi K, Tomemori R, Endo T, Nakano T, Kusaka S.
    第69回日本臨床視覚電気生理学会・60th ISCEV  2023/03  京都市, 国立京都国際会館  藤田医科大学医学部眼科学教室
  • Digoxin retinopathy that mimics KCNV2 retinopathy
    Nagae Y, Kuniyoshi K, Kato J, Ishibashi M, Tanabe F, Okamoto N, Kusaka S.
    第69回日本臨床視覚電気生理学会・60th ISCEV  2023/03  京都市, 国立京都国際会館  藤田医科大学医学部眼科学教室
  • 〔特別講演〕難治性網膜硝子体疾患に対する外科的治療
    日下 俊次
    第99回新潟臨床眼科研究会  2023/03  新潟市, 新潟大学医学部有壬記念会館  新潟県眼科医会/日本アルコン株式会社
  • 小児網膜疾患の診断と治療-Update-
    日下 俊次
    第8回和歌山黄斑疾患セミナー  2023/03  和歌山市, 和歌山県民文化会館5階 大会議室(WEB開催)  バイエル薬品株式会社・参天製薬株式会社
  • 【特別講演】 難治性網膜硝子体疾患への外科的アプローチ
    日下 俊次
    NRC-なにわレチナ倶楽部  2023/03  日本(Web開催)  なにわレチナ倶楽部 バイエル薬品株式会社 参天製薬株式会社
  • 【Pediatric Retina】Surgical Treatment for CXLRS With Bullous Schisis Cavity
    Kusaka S.
    The38th APAO2023  2023/02  Kuala Lumpur, Malaysia  APAO
  • [POSTER SESSION 1]Interaction between Plasminogen Activation System and Fibronectin in the Control of Alpha-smooth Muscle Actin Expression in Corneal Fibroblasts
    Yunoki M, Sugioka K, Nishida T, Murakami J, Kida T, Fukuda F, Kusaka S.
    ISER 2023  2023/02  Gold Coast, Australia  Meeting International Society for Eye Research
  • 【特別講演】難治性網膜硝子体疾患に対する外科的治療
    日下 俊次
    第15回昭和大学眼科学術講演会  2023/02  ハイブリッド開催(ホテル雅叙園東京3階『シリウス』/WEB配信)  昭和大学眼科学術研究会 千寿製薬株式会社
  • Linear sebaceous nevus syndrome with keratoconjunctival choristoma: case report
    後藤 夕輝, 江口 洋, 堀田 芙美香, 吉田 健司, 桑原 一彦, 筑後 孝章, 日下 俊次.
    角膜カンファランス2023  2023/02  横浜市, パシフィコ横浜  杏林大学医学部眼科学教室
  • ジゴキシン網膜症の1例
    永江 由季, 國吉 一樹, 加藤 順司, 石橋 眞里佳, 七部 史, 岡本 直之, 日下 俊次.
    第452回大阪眼科集談会プログラム  2023/02  大阪市, 毎日新聞オーバルホール  一般社団法人大阪府眼科医会
  • 眼底所見が正常な錐体ジストロフィ
    國吉 一樹, 角田 和繁, 林 孝彰, 永江 由季, 藤波 芳, 須賀 晶子, 岩田 岳, 日下 俊次.
    第452回大阪眼科集談会プログラム  2023/02  大阪市, 毎日新聞オーバルホール  一般社団法人大阪府眼科医会
  • RBに伴う合併症に対する硝子体手術
    日下 俊次
    硝子体手術フォーラム  2023/02  留寿都, ルスツリゾート  桐生純一
  • 【特別講演】難治性網膜硝子体疾患に対する治療 Update
    日下 俊次
    第91回宮崎大学眼科研究会  2023/01  宮崎市, 宮崎KITENビル8F大会議室
  • 眼科コールドケース
    Osawa S, kadonosono, K, Kamei M, Kusaka S, Kuriyama S, Honda S, Nakao S, Kita M.
    眼科コールドケース2023  2023/01  日本(Web開催)  ノバルティスファーマ株式会社
  • 黄斑円孔術後に黄斑萎縮をきたした網膜色素変性の1例
    後藤 夕輝, 國吉 一樹, 萱澤 朋泰, 日下 俊次.
    第61回日本網膜硝子体学会総会  2022/12  大阪市, 大阪国際会議場  関西医科大学医学部 眼科学教室
  • 網膜動脈閉塞症に対する硝子体手術
    日下 俊次, 眞野 福太郎, 萱澤 朋泰, 野本 裕貴, 栗原 智樹, 國吉 一樹.
    第61回日本網膜硝子体学会総会  2022/12  大阪市, 大阪国際会議場  関西医科大学医学部 眼科学教室
  • [イブニングセミナー1 どこまでやるの?硝子体手術My Way] どこまで追求?硝子体手術My Way
    日下 俊次.
    第61回日本網膜硝子体学会総会  2022/12  大阪市, 大阪国際会議場メインホール  関西医科大学医学部 眼科学教室
  • 【サテライトセミナー】未熟児網膜症診療の現状と課題
    日下 俊次
    第66回日本新生児成育医学会・学術集会 (内 第 48 回ハイリスク児フォローアップ研究会 )  2022/11  横浜市, パシフィコ横浜 会議センター  東京女子医科大学附属足立医療センター 新生児科
  • 〔Mysterious Retina Case 4〕Pediatric EMP of unknown etiology
    Kusaka S.
    The 15th APVRS  2022/11  Taipei, Taiwan  Asia-Pacific Vitreo-retina Society
  • Coats Disease: Clinical Presentation and Current Management
    Kusaka S.
    The 15th APVRS  2022/11  Taipei, Taiwan  Asia-Pacific Vitreo-retina Society
  • 両眼の視神経障害を合併したLeigh脳症の1例
    田村 佳菜子, 國吉 一樹, 道浦 徹, 上田 昌美, 高嶋 博, 橋口 昭大, 樋口 雄二郎, 永井 義隆, 日下 俊次.
    第60回日本神経眼科学会総会  2022/11  倉敷市, 倉敷市芸文館  川崎医科大学 眼科学1教室
  • 【特別講演】難治性網膜硝子体疾患に対する治療 Update
    Kusaka S.
    第31回東邦大学医療センター大橋病院と渋谷区・世田谷区・目黒区眼科医会合同勉強会  2022/10  日本(Web開催)  東邦大学医療センター大橋病院・渋谷区眼科医会・世田谷区眼科医会・目黒区眼科医会・参天製薬株式会社
  • 間欠性外斜視の眼位コントロールにおける視距離の影響
    高田 遼太, 若山 曉美, 松本 富美子, 沼田 卓也, 七部 史, 日下 俊次.
    第63回日本視能矯正学会  2022/10  大阪市, 大阪国際会議場  公益社団法人日本視能訓練士協会
  • [インストラクションコース] 網膜ファイトクラブ round18 ―症例をシェアして自分のものにする.
    喜多 美穂里, 大島 佑介, 門之園 一明, 木村 英也, 日下 俊次, 栗山 晶治, 竹内 忍.
    第76回日本臨床眼科学会  2022/10  東京国際フォーラム・JPタワー ホール&カンファレンス  東京女子医科大学眼科学
  • [一般講演41 ぶどう膜炎と悪性腫瘍] 中枢神経悪性リンパ腫に対するチラブルチニル投与に伴い眼所見が改善した3例.
    岩橋 千春, 川口 奈都美, 坂本 万寿夫, 大黒 伸行, 日下 俊次.
    第76回日本臨床眼科学会  2022/10  東京国際フォーラム・JPタワー ホール&カンファレンス  東京女子医科大学眼科学
  • [一般講演22 前眼部感染症とアレルギー] Aspergillus fumigatus keratitis角膜炎から分離された真菌株の相同性検証.
    堂本 綾, 江口 洋, 堀田 芙美香, 新居 鉄平, 矢口 貴志, 下村 嘉一, 日下 俊次.
    第76回日本臨床眼科学会  2022/10  千代田区, 東京国際フォーラム・JPタワー ホール&カンファレンス  東京女子医科大学眼科学
  • [一般講演3 未熟児網膜症他]牽引性網膜剥離を呈した先天性プロテインC欠乏症の2例.
    栗原 智樹, 大賀 智行, 遠藤 高生, 小幡 峻平, 西尾 尚記, 祝原 賢幸, 平田 克弥, 和田 和子, 日下 俊次.
    第76回日本臨床眼科学会  2022/10  千代田区, 東京国際フォーラム・JPタワー ホール&カンファレンス  東京女子医科大学眼科学
  • Aspergillus fumigatus角膜炎から分離された真菌株の相同性検証.
    堂本 綾, 江口 洋, 堀田 芙美香, 新居 鉄平, 矢口 貴志, 下村 嘉一, 日下 俊次.
    第450回大阪眼科集談会  2022/10  Web開催  大阪府眼科医会
  • 日常生活における視野異常の自覚とタブレット型視野計Multi-stimulus Vision tester(MVT)の有用性.
    石橋 眞里佳, 松本 長太, 七部 史, 野本 裕貴, 日下 俊次, 岩瀬 愛子.
    第33回日本緑内障学会  2022/09  横浜市, パシフィコ横浜 会議センター  日本緑内障学会
  • 緑内障眼におけるimo vifaでの視野検査.
    野本 裕貴, 松本 長太, 南野 麻美, 岩瀬 愛子, 小池 英子, 木村 伸司, 日下 俊次.
    第33回日本緑内障学会  2022/09  横浜市, パシフィコ横浜 会議センター  日本緑内障学会
  • タブレット型視野計Multi-Stimulus vision testerにおける年齢の影響.
    七部 史, 松本 長太, 石橋 眞里佳, 野本 裕貴, 日下 俊次, 岩瀬 愛子.
    第33回日本緑内障学会  2022/09  横浜市, パシフィコ横浜 会議センター  日本緑内障学会
  • Surgical outcome of traction retinal detachment associated with FEVR  [Invited]
    Kusaka S.
    WOC2022  2022/09  Australia(Web開催)  International Council of Ophthalmology
  • 近畿大学におけるデスメ膜内皮移植術の術後成績
    堀田 芙美香, 江口 洋, 西田 功一, 日下 俊次.
    第27回大阪眼科手術シンポジウム  2022/09  大阪市, ザ・リッツカールトン大阪  千寿製薬株式会社
  • 小児白内障術後の角膜乱視の長期変化
    立花 都子, 七部 史, 前田 直之, 日下 俊次.
    第58回日本眼光学学会総会  2022/09  旭川市, 旭川市大雪クリスタルホール  日本眼光学学会
  • Master Class:-Training, Surgery & Telemedicine  [Invited]
    Kaul J S, Chandra P, Kusaka S, Ells A, Ozdek S.
    5th World ROP CONGRESS 2022  2022/09  Dubai, UAE  Indian ROP Society
  • Current concepts in ROP Surgery  [Invited]
    Kusaka S.
    5th World ROP CONGRESS 2022  2022/09  Dubai, UAE  Indian ROP Society
  • Successful treatment of retinal vasculitis associated with Synovitis, Acne, Pustulosis, Hyperostosis, and Octeitis syndrome with adalimumab
    Iwahahashi C, Sakamoto M, Kusaka S.
    22nd Euretina Congress  2022/09  Humburg, Germany(ハイブリッド開催)  Euretina
     
    期間中ポスター発表
  • Amalric triangular sign and carotid Doppler findings in central retinal artery occulusion
    Mana F, Okubo M, Sato T, Kusaka S.
    22nd Euretina Congress Hamburg  2022/09  Humburg, Germany(ハイブリッド開催)  EURETINA
  • RAOに対する硝子体手術
    日下 俊次
    Japan Macula Club 2022 第22回総会  2022/08  蒲郡市, 蒲郡クラシックホテル  Japan Macula Club
  • 角膜筋線維芽細胞への形質転換に対するウロキナーゼ型プラスミノーゲンアクチベーター(uPA)の役割.
    杉岡 孝二, 西田 輝夫, 髙橋 彩, 村上 純子, 眞野 福太郎, 福田 昌彦, 日下 俊次.
    第24回眼創傷治癒研究会  2022/08  広島市, ホテルグランヴィア広島
  • [Session 4. New Strategies and Devices.] New portable binocular perimeter imo vifa
    Matsumoto C, Nomoto H, Koike E, Tanabe F, Iwase A, Nozaki M, Minamino M, Kusaka S.
    24th Imaging and Perimetry Society Meeting  2022/08  Berkeley, USA  Imaging and Perimetry Society Department of Optometry & Vision Sciences The University of Melbourne
  • [Session 4. New Strategies and Devices.] The efficiency detection of a glaucoma visual field defect using a tablet perimetry tool: The Multi-Stimulus vision tester
    Tanabe F, Matsumoto C, Ishibashi M, Nomoto H, Kusaka S, Iwase A.
    24th Imaging and Perimetry Society Meeting  2022/08  Imaging and Perimetry Society Department of Optometry & Vision Sciences The University of Melbourne  Berkeley, USA
  • [Session 4. New Strategies and Devices.] Characteristic findings of functional visual loss with perimeter imo
    Sugino A, Matsumoto C, Tanabe F, Nomoto H, Kusaka S.
    24th Imaging and Perimetry Society Meeting  2022/08  Berkeley, USA  Imaging and Perimetry Society Department of Optometry & Vision Sciences The University of Melbourne
  • [Session 4. New Strategies and Devices.] Evaluation of a visual field test strategy AIZE-EX.
    Nomoto H, Matsumoto C, Kimura S, Yamanaka K, Kusaka S.
    24th Imaging and Perimetry Society Meeting  2022/08  Berkeley, USA  Imaging and Perimetry Society Department of Optometry & Vision Sciences The University of Melbourne
  • [Session 1. Big Data & Motion.] Measurement of fixational eye movements during visual field testing
    Ishibashi T, Matsumoto C, Nomoto H, Kimura S, Kusaka S.
    24th Imaging and Perimetry Society Meeting  2022/08  Berkeley, USA  Imaging and Perimetry Society Department of Optometry & Vision Sciences The University of Melbourne
  • 〔学術展示2〕網膜動静脈閉塞症を生じた SLE 網膜症の 2 例.
    佐藤 朋子, 坂本 万寿夫, 山雄 さやか, 岩橋 千春, 國吉 一樹, 日下 俊次.
    第38回日本眼循環学会  2022/07  富山市, 富山国際会議場  富山大学学術研究部医学系眼科学講座
  • 〔学術展示3〕眼球内容除去に至った脈絡膜血管腫の 1 例.
    岩橋 千春, 永江 由季, 野本 裕貴, 日下 俊次.
    第38回日本眼循環学会  2022/07  富山市, 富山国際会議場  富山大学学術研究部医学系眼科学講座
  • [一般講演6 ウイルス2] 健常者の眼表面ウイルス叢.
    堀田 芙美香, 江口 洋, 日下 俊次.
    フォーサム2022せとうち(第58回日本眼感染症学会)  2022/07  広島市, リーガロイヤルホテル広島・NTTクレドホール  第58回日本眼感染症学会・第55回日本眼炎症学会・第64回日本コンタクトレンズ学会総会・第10回日本涙道・涙液学会総会
  • [一般講演6 ウイルス2] ランドル環型角膜上皮症とOrthobunyavirusの関連性.
    江口 洋, 堀田 芙美香, 大家 義則, 前田 直之, 大橋 裕一, 日下 俊次.
    フォーサム2022せとうち(第58回日本眼感染症学会)  2022/07  広島市, リーガロイヤルホテル広島・NTTクレドホール  第58回日本眼感染症学会・第55回日本眼炎症学会・第64回日本コンタクトレンズ学会総会・第10回日本涙道・涙液学会総会
  • 原田病類似症状で発症したMTX-LPDの1例.
    坂本 万寿夫, 大久保 麻希, 岩橋 千春, 日下 俊次.
    フォーサム2022せとうち(第55回日本眼炎症学会)  2022/07  広島市, リーガロイヤルホテル広島・NTTクレドホール  第58回日本眼感染症学会・第55回日本眼炎症学会・第64回日本コンタクトレンズ学会総会・第10回日本涙道・涙液学会総会
  • SAPHO症候群に合併した網膜血管炎の1例.
    岩橋 千春, 坂本 万寿夫, 日下 俊次.
    フォーサム2022せとうち(第55回日本眼炎症学会)  2022/07  広島市, リーガロイヤルホテル広島・NTTクレドホール  第58回日本眼感染症学会・第55回日本眼炎症学会・第64回日本コンタクトレンズ学会総会・第10回日本涙道・涙液学会総会
  • [一般講演2 細菌2]硝子体手術後に発覚した緑膿菌による壊死性強膜炎の1例.
    髙橋 彩, 杉岡 孝二, 萱澤 真梨子, 福田 昌彦, 日下 俊次.
    フォーサム2022せとうち(第58回日本眼感染症学会)  2022/07  広島市, リーガロイヤルホテル広島・NTTクレドホール  第58回日本眼感染症学会・第55回日本眼炎症学会・第64回日本コンタクトレンズ学会総会・第10回日本涙道・涙液学会総会
  • FLUIDICS IN VR SURGERY  [Invited]
    Kusaka S.
    11th THESSALONIKI VITREO-RETINAL SUMMER SCHOOL  2022/07  Thessaloniki, Greece  LM VISION, diathlasis
  • PRIMERY VITRECTOMY FOR RETINA DETACHMEND WET LAB  [Invited]
    Kaynak S, Kusaka S.
    11th THESSALONIKI VITREO-RETINAL SUMMER SCHOOL  2022/07  Thessaloniki, Greece  LM VISION, diathlasis
  • STEP BY STEP VITRECTOMY  [Invited]
    Kusaka S.
    11th THESSALONIKI VITREO-RETINAL SUMMER SCHOOL  2022/07  Thessaloniki, Greece  LM VISION, diathlasis
  • [一般講演4 視野] 網膜色素変性患者に対する白内障手術後の視野変化.
    國吉 一樹, 永江 由季, 萱澤 朋泰, 松本 長太, 日下 俊次.
    第11回日本視野画像学会学術集会  2022/07  横浜市, 新横浜プリンスホテル  日本視野画像学会
  • [一般講演2 次世代視野]imo®Vifaを用いた意図的視野障害所見.
    杉野 日彦, 七部 史, 野本 裕貴, 松本 長太, 日下 俊次.
    第11回日本視野画像学会学術集会  2022/07  横浜市, 新横浜プリンスホテル  日本視野画像学会
  • [一般講演2 次世代視野]24plus(1-2)測定点での緑内障性視野障害の評価.
    野本 裕貴, 松本 長太, 杉野 日彦, 石橋 拓也, 七部 史, 萱澤 朋泰, 石橋 眞里佳, 日下 俊次.
    第11回日本視野画像学会学術集会  2022/07  横浜市, 新横浜プリンスホテル  日本視野画像学会
  • 網膜色素変性に合併した白内障に対する手術の術前・術後の視機能経過
    永江 由季, 國吉 一樹, 萱澤 朋泰, 松本 長太, 日下 俊次.
    第7回 Senju Online Joint Seminar  2022/06  配信:Zoomウェビナー(配信会場:筑波大学臨床講義室D)  千寿製薬株式会社
  • 髄膜腫術後の麻痺性斜視に対して視能訓練を施行した1例.
    歌村 圭介, 若山 曉美, 七部 史, 日下 俊次.
    第78回日本弱視斜視学会総会  2022/06  宇都宮市, 栃木県総合文化センター  国際医療福祉大学 保健医療学部 視機能療法学科
  • 横静脈洞狭窄に伴ううっ血乳頭に対しステント治療が奏功した1例
    川口 奈都美, 坂本 万寿夫, 日下 俊次
    第448回大阪眼科集談会  2022/06  日本(Web開催)  一般社団法人大阪府眼科医会
  • 未熟児網膜症に対する治療 update
    Kusaka S.
    第10回東京ベイエリア眼科講演会  2022/06  Web開催 配信会場:浦安ブライトンホテル/TKPガーデンシティPREMIUM心斎橋/群馬ロイヤルホテル  ノバルティスファーマ株式会社
  • パネルディスカッションⅡ「合併症」
    日下 俊次
    第21回硝子体手術ビデオセミナー 目指せ!硝子体マイスター  2022/05  品川区, 東京コンファレンスセンター  網膜硝子体手術研究会
  • 網膜剥離Ⅱ:「硝子体手術」
    日下 俊次
    第21回硝子体手術ビデオセミナー 目指せ!硝子体マイスター  2022/05  港区,東京コンファレンスセンター・品川  網膜硝子体手術研究会
  • Pediatric Retina Case Discussion  [Invited]
    Chan RVP, Kusaka S, Kychenthal A, Lee TC.
    Retina World Congress2022  2022/05  Fort Lauderdale, USA  Retina World Congress
  • Anti-VEGF injections in the management of Retinopathy of prematurity: What we learned in the last decade?
    Agarwal-Sinha S, Kondo H, Kusaka S, Fukushima Y, Wu WC.
    ARVO 2022 Annual Meeting  2022/05  Denver,USA  ARVO
  • Treatment of tractional retinal detachment in eyes with familial exudative Vitreoretinopathy
    Oga T, Kuniyoshi K, Iwahashi C, Mano F, Kusaka S.
    FUJI RETINA 2022  2022/04  Tokyo, Japan
  • Recurrent retinal detachment in a child with morning glory syndrome and intellectual disability.
    Sato T, Kuniyoshi K, Kodama T, Kusaka S.
    FUJI RETINA  2022/04  Toranomon Hills, Minato-ku, Tokyo  JRVS (Japan Retina and Vitreous Society)
  • 未熟児網膜症に対する抗VEGF治療
    日下 俊次
    第126回日本眼科学会総会  2022/04  大阪市, 大阪国際会議場  公益財団法人 日本眼科学会
  • 網膜色素変性患者に対する白内障手術の術前・術後の視力経過.
    永江 由季, 國吉 一樹, 萱澤 朋泰, 日下 俊次.
    第126回日本眼科学会総会  2022/04  大阪市, 大阪国際会議場  公益財団法人日本眼科学会
  • 硝子体手術を要した瘢痕期未熟児網膜の臨床的特徴と手術成績.
    眞野 福太郎, 岩橋 千春, 國吉 一樹, 日下 俊次.
    第126回日本眼科学会総会  2022/04  大阪市, 大阪国際会議場  公益財団法人日本眼科学会
  • CTNNB1遺伝子変異を有する症候性家族性滲出性硝子体網膜症の臨床像
    成瀬 翔, 岡本 美里, 林 孝彰, 細野 克博, 堀田 喜裕, 岡島 道子, 渡邉 淳, 東 範行, 日下 俊次, 近藤 寛之.
    第126回日本眼科学会総会  2022/04  大阪市, 大阪国際会議場  公益財団法人日本眼科学会
  • 我が国の家族性滲出性硝子体網膜症の250家系の遺伝的解析
    近藤 寛之, 松下 五佳, 川村 朋子, 内尾 英一, 日下 俊次, 林 孝彰, 白澤 誠, 仁科 幸子, 金子 優, 川崎 良, 坂本 泰二
    第126回日本眼科学会総会  2022/04  大阪市, 大阪国際会議場  公益財団法人日本眼科学会
  • [ランチョンセミナー9 スペシャリストが語る顕微鏡] 徹底解明: OCT搭載型Proveo8.
    日下 俊次
    第126回日本眼科学会総会  2022/04  大阪市, 大阪国際会議場  公益財団法人日本眼科学会・ライカマイクロシステムズ株式会社
  • 未熟児網膜症に対する硝子体手術
    日下 俊次
    第126回日本眼科学会総会  2022/04  大阪市, 大阪国際会議場  公益財団法人日本眼科学会
  • 【特別講演Ⅰ】難治性網膜硝子体疾患の治療
    日下 俊次
    【WEB開催】第1回高槻眼疾患フォーラム  2022/03  WEB開催  高槻眼疾患フォーラム・バイエル薬品株式会社・参天製薬株式会社
  • 未熟児網膜症:anti-VEFG時代の硝子体手術
    日下 俊次
    未熟児網膜症診療 Up to date  2022/03  千代田区, 日本教育会館(一ツ橋ホール)  第47回日本小児眼科学会/ノバルティスファーマ株式会社
  • 眼内レンズ強膜内固定後の虹彩捕獲に対し周辺虹彩切除術が有効であった1例.
    飯森 宏仁, 奥嶋 奈美, 上甲 武志, 白石 敦, 日下 俊次.
    第47回日本小児眼科学会総会  2022/03  千代田区, 日本教育会館  日本小児眼科学会
  • Vitrectomy and external drainage of subretinal fluid containing high concentration of vascular endothelial growth factor for advanced coats disease.
    眞野 福太郎, 松下 五佳, 近藤 寛之, 歌村 翔子, 近藤 千桜里, 日下 俊次.
    第47回日本小児眼科学会総会  2022/03  日本小児眼科学会  日本小児眼科学会
  • KCNV2網膜症同胞例の長期経過
    佐藤 朋子, 國吉 一樹, 林 孝彰, 溝渕 圭, 西脇 弘一, 初川 嘉一, 中野 匡, 日下 俊次.
    第47回日本小児眼科学会総会  2022/03  千代田区, 日本教育会館(ハイブリッド開催)  日本小児眼科学会
  • 硝子体手術を要したabusive head traumaの3例.
    西田 功一, 國吉 一樹, 山本 拓広, 日下 俊次.
    第47回日本小児眼科学会総会  2022/03  千代田区, 日本教育会館(ハイブリッド開催)  日本小児眼科学会
  • 接触式広角眼底カメラRetcam��3とPanoCam™Soloの比較
    中嶌 彩夏, 日下 俊次, 國吉 一樹, 岩橋 千春, 眞野 福太郎, 大賀 智行.
    第47回日本小児眼科学会総会  2022/03  千代田区, 日本教育会館(ハイブリッド開催)  日本小児眼科学会
  • The Effect of Direct Maneuver for Retinal Arteries on CRAO or BRAO
    Kusaka S.
    Vail Vitrectomy 2022  2022/03  Vail, USA  Vail Vitrectmy Organizing Committee
  • Visual snow syndromeの2例
    田村 佳菜子, 國吉 一樹, 堀田 芙美香, 松本 長太, 日下 俊次.
    第4回OHKKの会  2022/03  日本(Web開催)
  • 自作移植片インサーターを用いたデスメ膜内皮移植術の術後中期成績.
    西田 功一, 江口 洋, 堀田 芙美香, 日下 俊次
    角膜カンファランス2022  2022/02  金沢市, 石川県立音楽堂/ANAクラウンプラザホテル金沢(ハイブリッド開催)  金沢大学医学部眼科学教室
  • ドナー角膜保存液のマイクロバイオームのショットガンメタゲノム解析.
    堀田 芙美香, 江口 洋, 桑原 知巳, 今大路 治之, 日下 俊次.
    角膜カンファランス2022  2022/02  金沢市, 石川県立音楽堂/ANAクラウンプラザホテル金沢(ハイブリッド開催)  金沢大学医学部眼科学教室
  • 流行性角結膜炎罹患後にvault変化で視力低下をきたしたICL眼.
    佐藤 朋子, 江口 洋, 西田 功一, 堀田 芙美香, 日下 俊次.
    角膜カンファランス2022  2022/02  金沢市, 石川県立音楽堂/ANAクラウンプラザホテル金沢(ハイブリッド開催)  金沢大学医学部眼科学教室
  • ステロイド内服中に発症したStevens-Johnson 症候群の一例
    川口 奈都美, 岩橋 千春, 堀田 芙美香, 日下 俊次.
    第446回 大阪眼科集談会  2022/02  日本(Web開催)  一般社団法人大阪府眼科医会
  • 難治性網膜硝子体疾患の外科的治療
    日下 俊次
    第10回宮城オフサルモロジーセミナー  2022/02  日本(Web開催)  宮城県眼科医会 千寿製薬株式会社
  • RBに伴う合併症に対する硝子体手術
    日下 俊次
    Winter Vitrectomy Meeting  2022/02  留寿都, ルスツリゾート
  • 眼科コールドケース
    大澤 俊介, 門之園 一明, 瓶井 資弘, 日下 俊次, 栗山 晶治, 本田 茂, 森實 祐基, 喜多 美穂里
    眼科コールドケース2022  2022/01  TKPガーデンシティ京都タワーホテル2F【桜】,京都市(Web開催)  ノバルティスファーマ株式会社
  • Surgery for Complex Retinal Detachment in Pediatric Population
    Kusaka S
    APVRS 2021 Virtual  2021/12  Hong Kong(Virtual)  Asia-Pacific Vitreo-retina Society (APVRS)
  • 緑内障における多点刺激法を応用したタブレット型視野計Multi-Stimulate Visual field test (MVT)の有用性
    七部 史, 石橋 眞里佳, 松本 長太, 野本 裕貴, 日下 俊次.
    第445回大阪眼科集談会  2021/12  日本(Web開催)  一般社団法人大阪府眼科医会
  • 網膜中心動脈閉塞症における脈絡膜循環障害の検討.
    大久保 麻希, 眞野 福太郎, 山雄 さやか, 國吉 一樹, 日下 俊次.
    第60回網膜硝子体学会  2021/12  千代田区, 東京国際フォーラム  東京女子医科大学 眼科学教室
  • Surgical outcomes for retinal detachment with familialexudative vitreoretinopathy
    Oga T, Kuniyoshi K, Iwahashi C, Mano F, Kondo H, Kusaka S.
    第60回日本網膜硝子体学会総会  2021/12  千代田区, 東京国際フォーラム  東京女子医科大学 眼科学教室
  • 朝顔症候群に合併した網膜剥離に対する手術成績の検討
    山雄 さやか, 日下 俊次
    第60回日本網膜硝子体学会総会  2021/12  東京(ハイブリッド開催)  東京女子医科大学 眼科学教室
  • [優秀演題シンポジウム2] Surgical outcomes for retinal detachment with familial exudative vitreoretinopathy
    Oga T, Kuniyoshi K, Iwahashi C, Mano F, Kondo H, Kusaka S
    第60回日本網膜硝子体学会総会  2021/12  東京(ハイブリッド開催)  東京女子医科大学 眼科学教室
  • ラニビズマブ硝子体内注射後細菌性眼内炎に対し硝子体手術を施行した未熟児網膜症の例(学術展示)
    黒木 迪子, 今里 美幸, 梶原 夏輝, 日高 貴子, 杉田 直大, 福島 慶美, 柊山 剰, 日下 俊次, 中馬 秀樹, 池田 康博
    第60回日本網膜硝子体学会総会  2021/12  東京(ハイブリッド開催)  東京女子医科大学 眼科学教室
     
    ポスター発表のため期間は2021.12.3-2021.12.5
  • 硝子体手術 update
    日下 俊次
    第14回なでしこの会  2021/11  大阪市, ホテルモントレ グラスミア大阪 21F『スノーベリー』  ノバルティスファーマ株式会社
  • W-60R挿入眼とLS-313 MF15挿入眼における立体視機能の検討
    酒井 邦章, 若山 暁美, 松本 富美子, 高田 遼太, 萱澤 朋泰, 日下 俊次
    第62回日本視能矯正学会  2021/11  千代田区, 東京国際フォーラム ホールA  視能訓練士協会
  • 未熟児網膜症診療Update
    日下 俊次
    栃眼医独協眼科病診連携の会-Web講演-  2021/11  宇都宮市,ホテルマイステイズ宇都宮  栃木県眼科医会
  • 先天網膜分離症の硝子体手術後に眼圧上昇をきたした1例.
    永江 由季, 野本 裕貴, 日下 俊次.
    第59回PACGs  2021/11  大阪(Web開催)
  • 先天網膜分離症の光干渉断層計検査所見
    中嶌 彩夏, 國吉 一樹, 岩橋 千春, 眞野 福太郎, 日下 俊次
    第75回日本臨床眼科学会  2021/10  福岡市, 福岡国際会議場  鹿児島大学大学院医歯学総合研究科 感覚器病学講座 眼科学分野
  • Visual snow syndromeの2例
    田村 佳菜子, 國吉 一樹, 堀田 芙美香, 日下 俊次
    第75回日本臨床眼科学会  2021/10  福岡市, 福岡国際会議場  鹿児島大学大学院医歯学総合研究科 感覚器病学講座 眼科学分野
  • 新国際分類に基づく stage 5 未熟児網膜症に対す る手術成績評価
    眞野 福太郎, 岩橋 千春, 國吉 一樹, 日下 俊次
    第75回日本臨床眼科学会  2021/10  福岡市, 福岡国際会議場  鹿児島大学大学院医歯学総合研究科 感覚器病学講座 眼科学分野
  • タブレット型視野計Multi-Stimulus vision test(MVT) の精度および再現性
    七部 史; 石橋 眞里佳; 松本 長太; 野本 裕貴; 日下 俊次
    第75回日本臨床眼科学会  2021/10  福岡市, 福岡国際会議場  鹿児島大学大学院医歯学総合研究科 感覚器病学講座 眼科学分野
  • 網膜剥離ファイトクラブ round 17 ―症例をシェアして自分のものにする―
    喜多 美穂里, 大島 佑介, 門之園 一明, 木村 英也, 日下 俊次, 栗山 晶治, 竹内 忍
    第75回日本臨床眼科学会  2021/10  福岡市, 福岡国際会議場  鹿児島大学大学院医歯学総合研究科 感覚器病学講座 眼科学分野
  • 光干渉断層血管撮影により、網膜出血下の細動脈瘤を検出できた1例
    杉野 日彦, 眞野 福太郎, 佐藤 朋子, 日下 俊次.
    第75回日本臨床眼科学会  2021/10  福岡市, 福岡国際会議場/福岡サンパレス マリンメッセ福岡A館  鹿児島大学大学院医歯学総合研究科 感覚器病学講座 眼科学分野
  • 糖尿病網膜症の治療 update
    日下 俊次
    Retina Online Theater Vol.6  2021/10  日本(Web開催)  バイエル薬品株式会社 参天製薬株式会社
  • ROP Screening in Japan
    Kusaka S.
    Mastermind Neonatal Eye Imaging Event (Webinar)  2021/10  Natus medical incorporated
  • おさえておきたい小児網膜疾患のポイント
    日下 俊次
    第4回Senju Online Joint Seminar  2021/10  日本(Web開催)  千寿製薬株式会社
  • 線維柱帯切除後の悪性緑内障に対しirido-zonulo-hyaloido vitrectomyを行った1例
    野本 裕貴, 山田 泰生, 日下 俊次.
    第444回 大阪眼科集談会  2021/10  日本(Web開催)  大阪府眼科医会
  • How Long do the Lenses Remain Clear Following Lens-Sparing Vitrectomy for ROP
    Kusaka S.
    TMS 2021  2021/09  台北市(Web開催)  TheTaiwan Macula Society
  • Oral Fluorescein Angiography with Ultra-wide-field Imaging System for Pediatric Retinal Disorders
    Kusaka S.
    Advances In Pediatric Retina(APR)2021 virtual  2021/09  Durham(Virtual)  Department Of Ophthalmology, Duke University School of Medicine
  • 特別講演:硝子体手術の進歩と難治性疾患への対処法
    日下 俊次
    第84回埼玉眼科講習会  2021/09  蒲郡クラシックホテル, 蒲郡市
  • 未熟児網膜症に対する抗VEGF 療法
    日下 俊次
    日本眼科医会第80回生涯教育講座 福岡講座(Web開催)  2021/08  Web開催  公益社団法人日本眼科医会
  • ROPに対するIVR
    日下 俊次
    Japan Macula Club 第22回学術講演会  2021/08  蒲郡クラシックホテル, 蒲郡市  Japan Macula Club
  • Visual snow syndromeの2例
    田村 佳菜子, 國吉 一樹, 堀田 芙美香, 日下 俊次.
    第443回 大阪眼科集談会プログラム  2021/08  日本(Web開催)  一般社団法人大阪府眼科医会
  • 先天網膜分離症の光干渉断層計検査所見
    中嶌 彩夏, 國吉 一樹, 岩橋 千春, 眞野 福太郎, 日下 俊次.
    第443回 大阪眼科集談会プログラム  2021/08  日本(Web開催)  一般社団法人大阪府眼科医会
  • 未熟児網膜症に対する抗 VEGF 療法
    日下 俊次
    日本眼科医会第80回生涯教育講座 名古屋講座(Web開催)  2021/07  名古屋市  公益社団法人日本眼科医会
  • ハードコンタクトレンズ装用により視力が改善した小児無水晶体眼の2症例
    立花 都子, 宮本 裕子, 月山 純子, 日下 俊次, 下村 嘉一.
    フォーサム2021仙台(第 63 回日本コンタクトレンズ学会総会・ハイブリッド開催)  2021/07  仙台市, 仙台国際センター  日本コンタクトレンズ学会
  • Streptococcus, Gemella, Candidaによる角膜混合感染症の1例
    川口 奈都美, 江口 洋, 堀田 芙美香, 日下 俊次, 宮本 龍郎, 桑原 知己, 矢口 貴志, 川上 龍三郎.
    フォーサム2021仙台(第 57 回日本眼感染症学会・ハイブリッド開催)  2021/07  仙台市, 仙台国際センター  日本眼感染症学会
  • 帯状角膜変性症治療後のCorynebacterium propinquum角膜症
    杉野 日彦, 江口 洋, 堀田 芙美香, 宮本 龍郎, 日下 俊次.
    フォーサム2021仙台(第 57 回日本眼感染症学会・ハイブリッド開催)  2021/07  仙台市, 仙台国際センター  日本眼感染症学会
  • 未熟児網膜症に対する抗VEGF 療法
    日下 俊次
    日本眼科医会第80回生涯教育講座 東京講座(Web開催)  2021/07  東京都  公益社団法人日本眼科医会
  • 後天内斜視の融像機能の検討
    下屋 美妃, 若山 曉美, 松本 富美子, 白石 ゆかり, 七部 史, 沼田 卓也, 日下 俊次.
    第77回日本弱視斜視学会総会  2021/07  横浜市, 新横浜プリンスホテル  日本弱視斜視学会
  • 不同視弱視の治療経過の向上と抑制の関係
    白石 ゆかり, 若山 曉美, 松本 富美子, 七部 史, 沼田 卓也, 日下 俊次.
    第77回日本弱視斜視学会総会  2021/07  横浜市, 新横浜プリンスホテル  日本弱視斜視学会
  • 先天網膜分離症に対する硝子体手術の治療成績
    岩橋 千春, 松下 五佳, 近藤 寛之, 國吉 一樹, 日下 俊次
    第46回日本小児科学会総会(ハイブリッド開催)  2021/06  北九州国際会議場, 北九州市  産業医科大学
  • 未熟児網膜症に対するranibizumab単独投与治療後の経過
    歌村 翔子, 國吉 一樹, 岩橋 千春, 七部 史, 坂本 万寿夫, 和田 紀久, 日下 俊次
    第46回日本小児科学会総会(ハイブリッド開催)  2021/06  北九州国際会議場, 北九州市  産業医科大学
  • 家族性滲出性硝子体網膜症所見を呈したRubinstein-Taybi症候群の一例
    川口 奈都美, 遠藤 高生, 大久保 麻希, 山雄 さやか, 日下 俊次
    第46回日本小児科学会総会(ハイブリッド開催)  2021/06  北九州国際会議場, 北九州市  産業医科大学
  • フルオレセイン経口投与での超広角走査レーザー検眼鏡による蛍光眼底造影の有用性
    山雄 さやか, 辻岡 大志, 高田 遼太, 松本 富美子, 日下 俊次
    第46回日本小児科学会総会(ハイブリッド開催)  2021/06  北九州国際会議場, 北九州市  産業医科大学
  • 複数回の角膜移植で失明を免れた淋菌性角結膜炎による角膜穿孔の1例
    中嶌 彩夏, 江口 洋, 堀田 芙美香, 日下 俊次.
    第442回 大阪眼科集談会プログラム  2021/06  日本(Web開催)  一般社団法人大阪府眼科医会
  • 帯状角膜変性症治療後の Corynebacterium propinquum 角膜炎
    杉野 日彦, 江口 洋, 堀田 芙美香, 宮本 龍郎, 日下 俊次
    第442回 大阪眼科集談会プログラム  2021/06  日本(Web開催)  一般社団法人大阪府眼科医会
  • 心因性視覚障害における imo両眼開放ランダム視野検査の有用性について
    杉野 日彦, 野本 裕貴,七部 史, 山雄 さやか, 松本 長太, 日下 俊次.
    第135回南大阪眼科勉強会 (WEB開催)  2021/05  日本(Web開催)  近畿大学医学部眼科学教室
  • 最近の開放性眼外傷の受傷転機と治療予後
    大賀 智行, 近藤 千桜里, 萱澤 朋泰, 杉岡 孝二, 野本 裕貴, 國吉 一樹, 堀田 芙美香, 日下 俊次.
    第135回南大阪眼科勉強会 (WEB開催)  2021/05  日本(Web開催)  近畿大学医学部眼科学教室
  • 裂孔原性網膜剥離に対する硝子体手術後の非伏臥位の有用性について
    萱澤 朋泰, 國吉 一樹, 野本 裕貴, 杉岡 孝二, 日下 俊次.
    第135回南大阪眼科勉強会 (WEB開催)  2021/05  日本(Web開催)  近畿大学医学部眼科学教室
  • ヘッドマウント型視野計imoを用いた視野検査中の固視微動測定
    石橋 拓也, 松本 長太, 野本 裕貴, 木村 伸司, 日下 俊次
    第125回日本眼科学会総会  2021/04  東京都(Web開催)  日本眼科学会
     
    Web開催
  • 心因性視覚障害におけるimo両眼開放ランダム視野検査の有用性について
    杉野 日彦, 野本 裕貴, 松本 長太, 七部 史, 山雄 さやか, 日下 俊次.
    第10回日本視野画像学会学術集会  2021/04  Web開催  日本視野画像学会
  • 視野検査中の固視微動測定
    石橋 拓也, 松本 長太, 野本 裕貴, 木村 伸司, 日下 俊次
    第10回日本視野画像学会学術集会  2021/04  Web開催  日本視野画像学会
  • Visual function in patients with retinitis pigmentosa
    國吉 一樹, 佐藤 朋子, 上野 覚, 日下 俊次
    The 125th Annual Meeting of the Japanese Ophtalmological society  2021/04  大阪国際会議場, 大阪市
  • Evaluation of microsaccades using head-mounted perimeter imo
    石橋 拓也, 松本 長太, 野本 裕貴, 木村 伸司, 日下 俊次
    The 125th Annual Meeting of the Japanese Ophtalmological society  2021/04  大阪国際会議場, 大阪市
  • Characteristics of eyes requiring vitrectomy after anti-VEGF therapy for ROP
    近藤 千桜里, 岩橋 千春, 國吉 一樹, 日下 俊次
    The 125th Annual Meeting of the Japanese Ophtalmological society  2021/04  大阪国際会議場, 大阪市
  • Postoperative outcomes of LS-313 MF15 and W-60R for bilateral cataract surgery
    萱澤 朋泰, 日下 俊次
    The 125th Annual Meeting of the Japanese Ophtalmological society  2021/04  大阪国際会議場, 大阪市
  • Clinical and genetic findings of Japanese patients with enhanced S-cone syndrome
    林 孝彰, 溝渕 圭, 亀谷 修平, 國吉 一樹, 日下 俊次, 上野 真治, 中野 匡
    The 125th Annual Meeting of the Japanese Ophtalmological society  2021/04  大阪国際会議場, 大阪市
  • DSAEK後の早期移植片機能不全にDMEKを施行した1例
    永江 由季, 江口 洋, 堀田 芙美香, 日下 俊次.
    第441回大阪眼科集談会(ハイブリッド開催)  2021/04  大阪市(Web開催)  大阪府眼科医会
  • 家族性滲出性網膜症様所見を呈したRubinstein-Taybi症候群の一例
    川口 奈都美, 遠藤 高生, 大久保 麻希, 山雄 さやか, 日下 俊次
    第441回大阪眼科集談会(ハイブリッド開催)  2021/04  大阪市(Web開催)  大阪府眼科医会
  • 非典型的な黄斑病変を示した先天網膜分離症の1例
    永江 由季, 國吉 一樹, 林 孝彰, 近藤 千桜里, 亀谷 修平, 岩田 岳, 日下 俊次.
    第3回OHKKの会  2021/03  日本(Web開催)  第3回OHKKの会・参天製薬
  • デスメ膜内皮移植術 (DMEK) 後2週間以内に視力が大幅に改善した3例
    若山 典子, 江口 洋, 堀田 芙美香, 日下 俊次
    第439回大阪眼科集談会  2020/12  大阪市(Web開催)  一般社団法人大阪府眼科医会
  • 眼表面常在細菌に対する各種キノロン薬の抗菌活性
    川口 奈都美, 江口 洋, 堀田 芙美香, 日下 俊次, 西田 功一, 下村 嘉一
    第439回大阪眼科集談会  2020/12  大阪市(Web開催)  一般社団法人大阪府眼科医会
  • 難治性網膜硝子体疾患への挑戦
    日下 俊次
    網膜疾患研究会  2020/12  Web開催 (久留米翠香園ホテル/福岡サンパレスより配信)  久留米大学医学部 眼科学講座
  • Association between Choroidal Features and Systemic Severity in Amyloidosis.
    Mano F, Pavesio C, Khalid H, Keane PA, Pulido JS, Kusaka S
    第59回日本網膜硝子体学会総会  2020/11  福岡市(ハイブリッド開催)  鹿児島大学大学院 医歯学総合研究科 先進治療科学専攻 感覚器病学講座 眼科学研究分野
  • 第59回日本網膜硝子体学会総会
    佐藤 朋子, 國吉 一樹, 日下 俊次
    第59回日本網膜硝子体学会総会  2020/11  福岡市(ハイブリッド開催)  鹿児島大学大学院 医歯学総合研究科 先進治療科学専攻 感覚器病学講座 眼科学研究分野
  • 両眼同時白内障手術に用いたLS-313 MF15とW-60Rの臨床成績
    萱澤 朋泰, 日下 俊次
    第74回日本臨床眼科学会  2020/10  東京(Web開催)
  • 緑内障眼における24plus (1) 測定点での視野評価
    野本 裕貴, 松本 長太, 杉野 日彦, 奥山 幸子, 日下 俊次
    第31回日本緑内障学会  2020/10  日本(Web開催)  大分大学医学部 眼科学講座
  • Surgery for Congenital X-Linked Retinoschisis.
    Kusaka S.
    2020 Taiwan Macula Society Annual Meeting  2020/09  台北市, 台湾(Web開催)  The Macula Society
  • Should We Perform Surgery for RD Associated with Morning Glory Syndrome?
    Kusaka S.
    2020 Taiwan Macula Society Annual Meeting  2020/09  台北市, 台湾(Web開催)  The Macula Society
  • Slow and Steady, Win the Race
    Kusaka S.
    2020 Taiwan Macula Society Annual Meeting  2020/09  台北市, 台湾(Web開催)  The Macula Society
  • 非典型的な黄斑病変を示した先天網膜分離症の1例
    永江 由季, 國吉 一樹, 林 孝彰, 近藤 千桜里, 亀谷 修平, 岩田 岳, 日下 俊次
    第68回日本臨床視覚電気生理学会  2020/09  日本(ハイブリッド開催)
  • 錐体障害が優位なAZOORの長期予後
    國吉 一樹, 松本 長太, 日下 俊次
    第68回日本臨床視覚電気生理学会  2020/09  日本(ハイブリッド開催)
  • 夜盲をきたした非典型的な先天網膜分離症の1例
    永江 由季, 近藤 千桜里, 國吉 一樹, 日下 俊次
    第437回大阪眼科集談会  2020/08  大阪市(Web開催)  一般社団法人大阪府眼科医会
  • 未熟児網膜症治療 Update
    日下 俊次
    Novartis Pharma Web Symposium  2020/07  大阪市(Web開催)  Novartis Pharma
  • Stage 4A 未熟児網膜症術後の長期視力経過
    立花 都子, 岩橋 千春, 國吉 一樹, 阿部 孝助, 日下 俊次
    第45回日本小児眼科学会総会  日本(Web開催)  日本小児眼科学会
  • Coats病における硝子体液および網膜下液のVEGF濃度の検討
    眞野 福太郎; 歌村 翔子; 近藤 千桜里; 大賀 智行; 日下 俊次
    第45回日本小児眼科学会総会  日本(Web開催)  日本小児眼科学会
  • PFV; Management of Anterior and/or Posterior Type.
    Kusaka S.
    World Ophthalmology Congress 2020 Virtual  2020/06  Cape Town, Republic of South Africa  ESOPRS
  • 両眼視野セルフチェックシートならびにEstermanと視野異常の自覚の関係
    石橋 眞里佳, 松本 長太, 奥山 幸子, 野本 裕貴, 七部 史, 萱澤 朋泰, 日下 俊次
    第9回日本視野画像学会学術集会  2020  日本(Web開催)  日本視野画像学会
  • 自家製移植片インサーターを用いたDMEKの手術成績.
    杉野 日彦, 江口 洋, 堀田 芙美香, 大久保 麻希, 近藤 千桜里, 日下 俊次.
    第124回日本眼科学会総会  2020/04  東京都 Web開催  公益財団法人 日本眼科学会
     
    Web開催
  • 最近の開放性眼外傷の受傷機転と治療予後
    近藤 千桜里, 大賀 智行, 萱澤 朋泰, 杉岡 孝二, 野本 裕貴, 國吉 一樹, 堀田 芙美香, 日下 俊次
    第124回日本眼科学会総会  2020  日本(Web開催)  日本眼科学会
  • 日常生活における視野異常の自覚と両眼視野セルフチェックシートの有用性について
    石橋 眞里佳, 松本 長太, 奥山 幸子, 野本 裕貴, 七部 史, 萱澤 朋泰, 江浦 真理子, 日下 俊次
    第124回日本眼科学会総会  2020  東京都(Web開催)  日本眼科学会
  • 眼表面マイクロバイオームとマイボグラフィー像との関係
    堀田 芙美香, 江口 洋, 今大路 浩之, 桑原 知巳, 日下 俊次
    第124回日本眼科学会総会  2020  東京都(Web開催)  日本眼科学会
  • 網膜色素変性の色覚異常
    國吉 一樹, 佐藤 朋子, 上野 覚, 日下 俊次
    第124回日本眼科学会総会  2020  東京都(Web開催)  日本眼科学会
  • Endo180が角膜線維芽細胞によるコラーゲンゲル収縮に与える影響
    西田 功一, 杉岡 孝二, 村上 純子, 髙橋 彩, 三島 弘, 西田 輝夫, 日下 俊次
    角膜カンファランス  2020  日本(Web開催)  日本大学医学部視覚科学系眼科学分野
  • 角膜ヘルペスの既往者でセツキシマブ併用化学療法中に角膜穿孔を生じた1例
    青松 圭一; 杉岡 孝二; 髙橋 彩; 福田 昌彦; 三島 弘; 日下 俊次
    角膜カンファランス  日本(Web開催)  日本大学医学部視覚科学系眼科学分野
  • Measurements of fixational eye movements using the head-mounted perimeter “imo”
    Ishibashi T, Matsumoto C, Nomoto H, Tanabe F, Kimura S, Kusaka S
    ARVO 2020 Annual Meeting  2020/05  Baltimore (Web開催)  Association for Research in Vision and Ophthalmology
  • ヘッドマウント型視野計imoを用いた視野検査中の固視微動測定
    石橋 拓也, 松本 長太, 野本 裕貴, 木村 伸司, 日下 俊次.
    第124回日本眼科学会総会  2020/04  千代田区, 東京国際フォーラム  公益財団法人 日本眼科学会
  • 難治性網膜硝子体疾患への挑戦
    日下 俊次.
    第48回 とやま眼科学術講演会  2020/02  富山県  富大眼科学術研究会
  • 特別講演:硝子体手術の進歩と難治性疾患への対処法
    日下 俊次
    アイカンファランス in 大阪南  2020/02  泉大津市
  • 特別講演:チャレンジ!難治性網膜硝子体学会
    日下 俊次
    第一回 網膜硝子体手術 Update in FUKUOKA  2020/02  福岡市
  • 硝子体混濁に対する硝子体手術
    日下 俊次
    硝子体手術フォーラム2020  2020/02  ルスツリゾート, 留寿都
  • 抗Myelin oligodendrocyte glycoprotein (MOG) 抗体陽性視神経炎の一例
    西田 功一, 青松 圭一, 七部 史, 日下 俊次
    第434回大阪眼科集談会  2020/02  大阪市, オーバルホール  一般社団法人大阪府眼科医会
  • 特別講演:硝子体手術の進歩と難治性疾患への対処法
    日下 俊次
    第30回 兵庫臨床眼科研究会  2020/01  神戸市  兵庫医科大学眼科学教室
  • Open globe injury
    Oga T, Kondo C, Mano F, Kusaka S.
    World Congress of Ocular Trauma  2019/12  New Delhi, India  The International Society of Ocular Trauma
  • Retinal Detachment Associated with Atopic Dermatitis  [Not invited]
    Kusaka S.
    World Congress of Ocular Trauma(WCOT 2019)  2019/12  Le Meridien,New Delhi  The International Society of Ocular Trauma
  • 視力低下を呈したIgG4関連疾患の一例.
    武田 麻希, 岩田 明子, 萱澤 朋泰, 石橋 拓也, 七部 史, 中尾 雄三, 日下 俊次.
    第433回大阪府眼科集談会  2019/12  大阪市, オーバルホール  一般社団法人大阪府眼科医会
  • Stage 4A未熟児網膜症に対する硝子体手術後再手術例の検討
    歌村 翔子, 國吉 一樹, 立花 都子, 日下 俊次
    第58回日本網膜硝子体学会総会  2019/12  長崎ブリックホール, 長崎市  長崎大学大学院医歯薬学総合研究科 眼科・視覚科学
  • 朝顔症候群に伴う網膜剥離に対する硝子体手術成績
    坂本 万寿夫, 國吉 一樹, 日下 俊次
    第58回日本網膜硝子体学会総会  2019/12  長崎ブリックホール, 長崎市  長崎大学大学院医歯薬学総合研究科 眼科・視覚科学
  • 裂孔原性網膜剥離に対する硝子体手術後の非伏臥位の有用性について
    萱澤 朋泰, 國吉 一樹, 野本 裕貴, 杉岡 孝二, 日下 俊次
    第58回日本網膜硝子体学会総会  2019/12  長崎新聞文化ホール・アストピア, 長崎市  長崎大学大学院医歯薬学総合研究科 眼科・視覚科学
  • 脈絡膜皺襞を呈したANCA関連血管炎の1例
    岩橋 千春, 杉野 日彦, 上野 覚, 山雄 さやか, 坂本 万寿夫, 日下 俊次
    第58回日本網膜硝子体学会総会  2019/12  長崎新聞文化ホール・アストピア, 長崎市  長崎大学大学院医歯薬学総合研究科 眼科・視覚科学
  • Invited lecture: Surgical Management of FEVR  [Invited]
    Kusaka S.
    2019 Korean Retina Society Annual Meeting  2019/12  Seoul,Korea  The Korean Retina Society
  • Invited lecture: Vitrectomy for ROP
    Kusaka S.
    2019 Korean Retina Society Annual Meeting  2019/12  Seoul,Korea  The Korean Retina Society
  • 特別講演:硝子体手術の進歩と難治性疾患への対処法
    日下 俊次
    奈良県立医科大学眼科学教室同窓会講演会  2019/12  大阪市,シェラトン都ホテル大阪  奈良県立医科大学眼科学教室
  • 間欠性外斜視の最大斜視角検出におけるPrism adaptation testとPatch testの比較検討.
    高田 遼太, 松本 富美子, 若山 曉美, 梅原 郁美, 歌村 圭介, 成田 竜, 酒井 邦章, 下屋 美妃, 七部 史, 沼田 卓也, 岩田 明子, 阿部 考助, 日下 俊次.
    第60回日本視能矯正学会  2019/11  福岡市, 福岡国際会議場  公益社団法人日本視能訓練士協会
  • 南大阪の病診連携について.
    日下 俊次
    第2回南大阪眼科autumnセミナー  2019/11  大阪市
  • シンポジウム:Vitrectomy for RD Associated with Morning Glory Syndrome
    日下 俊次
    13th Asia-Pacific Vitreoretinal Society Congress 2019 (11月22-24日、発表22日、上海)  2019/11  上海,中国  APVRS
  • 特別講演:硝子体手術の進歩と難治性疾患への対応
    日下 俊次
    第35回 大阪府眼科医会女性会員の集い  2019/11  大阪市  大阪府女医会
  • 特別講演:硝子体手術の進歩
    日下 俊次
    堺市医師会眼科医会総会  2019/11  堺市  堺市医師会
  • 日常生活における視野異常の自覚と両眼視やセルフチェックシート (CLOCK CHART binocular edition) の有用性について.
    石橋 眞里佳, 松本 長太, 奥山 幸子, 七部 史, 萱澤 朋泰, 江浦 真理子, 日下 俊次.
    第73回日本臨床眼科学会  2019/10  京都市,グランドプリンスホテル京都  滋賀医科大学眼科学講座
  • 視神経乳頭の異常収縮運動を伴う朝顔症候群の2例.
    坂本 万寿夫, 林 思音, 日下 俊次.
    第73回日本臨床眼科学会  2019/10  京都市, 国立京都国際会館  滋賀医科大学眼科学講座
  • 改正後の視野障害による等級の変動について.
    萱澤 朋泰, 松本 長太, 奥山 幸子, 國吉 一樹, 野本 裕貴, 七部 史, 日下 俊次.
    第73回日本臨床眼科学会  2019/10  京都市, 国立京都国際会館  滋賀医科大学眼科学講座
  • 〔シンポジウム〕未熟児網膜症診断・治療の最前線:外科的治療  [Not invited]
    日下 俊次
    第73回日本臨床眼科学会  2019/10  京都市, 国立京都国際会館・グランドプリンスホテル京都  滋賀医科大学眼科学講座
  • 特別講演:難治性網膜硝子体疾患に対する外科的治療
    日下 俊次
    第1 回沖縄眼科臨床懇話会  2019/10  那覇市,沖縄県立博物館・美術館  参天製薬, 琉球大学眼科
  • Longitudinal clinical course of patients with DRAM2-associated retinopathy and their electron microscopic findings in lymphocytes.
    Kuniyoshi K, Hayashi T, Kameya S, Katagiri S, Mizobuchi K, Tachibana T, Kubota D, Sakuramoto H, Tsunoda K, Fujinami K, Iwata T, Nakano T, Kusaka S.
    57th Symposium of the International Society for Clinical Electrophysiology of Vision  2019/10  Seoul, Korea  Young-Hoon Ohn & team
  • 成人の外斜視手術.
    七部 史, 阿部 考助, 岩田 明子, 若山 曉美, 関 ゆかり, 日下 俊次.
    第25回大阪眼科手術シンポジウム  2019/10  大阪市
  • 最新の白内障治療.
    日下 俊次.
    第32回近畿大学医学部市民公開講座  2019/09  大阪狭山市  近畿大学医学部眼科学教室
  • 日常生活における視野異常の自覚とクワトロチェッカーの有用性.
    石橋 眞里佳, 松本 長太, 奥山 幸子, 野本 裕貴, 七部 史, 萱澤 朋泰, 江浦 真理子, 日下 俊次.
    第30回日本緑内障学会  2019/09  熊本市, ホテル日航熊本  熊本大学病院
  • 視野測定プログラムAIZE、AIZE-EXにおける検査結果の変動.
    野本 裕貴, 松本 長太, 吉川 啓司, 南野 麻美, 奥山 幸子, 木村 伸司, 日下 俊次.
    第30回日本緑内障学会  2019/09  熊本市, ホテル日航熊本  熊本大学病院
  • Surgical Treatment of Coats Disease  [Not invited]
    Kusaka S.
    19th Euretina Congress  2019/09  Paris, France  Euretina
  • Vitrectomy and/or Anti-VEGF for ROP  [Not invited]
    Kusaka S.
    19th Euretina Congress  2019/09  Paris, France  Euretina
  • Surgery for FEVR: When and how?  [Not invited]
    Kusaka S.
    19th Euretina Congress  2019/09  Paris, France  Euretina
  • Endol80が角膜実質細胞コラーゲンゲル収縮に与える影響.
    西田 功一, 杉岡 孝二, 村上 純子, 髙橋 彩, 三島 弘, 西田 輝夫, 日下 俊次.
    第23回眼創傷治癒研究会  2019/08  宇都宮市, 宇都宮グランドホテル  眼創傷治癒研究会
  • 難治性網膜剥離に対する硝子体手術  [Not invited]
    日下 俊次
    第12回加越硝子体手術研究会  2019/08
  • Pediatric Retina  [Not invited]
    Kusaka S, Mogazhi MM, Ciardelli A, Tunay Zo.
    Mediterranean retina MeetingⅧ  2019/08  Dubrovnik, Croatia
  • [Instruction Course] Surgery for Coats disease.
    Kusaka S.
    Mediterranean retina Meeting Ⅷ  2019/08  Dubrovnik, Croatia
  • ヘッドマウント型視野計アイモが有用であった心因性視覚障害の1例.
    杉野 日彦, 野本 裕貴, 佐藤 寿樹, 松本 長太, 日下 俊次.
    第431回大阪眼科集談会  2019/08  大阪市, オーバルホール  一般社団法人大阪府眼科医会
  • Wyburn-Mason症候群のOCTA所見  [Not invited]
    山雄 さやか, 坂本 万寿夫, 日下 俊次
    第36回日本眼循環学会  2019/07  札幌市, ロイトン札幌  北海道大学大学院医学研究院眼科学教室
  • 〔症例検討〕著明な視力低下を呈したIgG4関連疾患の一例.
    武田 麻希, 岩田 明子, 萱澤 朋泰, 歌村 翔子, 石橋 拓也, 日下 俊次.
    第134回南大阪勉強会  2019/07  大阪狭山市  近畿大学医学部眼科学教室
  • 〔症例検討〕緑内障術後に脈絡膜剥離を生じた2例.
    野本 裕貴, 日下 俊次.
    第134回南大阪勉強会  2019/07  大阪狭山市  近畿大学医学部眼科学教室
  • 〔症例検討〕DRAM2関連網膜症の長期臨床経過.
    近藤 千桜里, 國吉 一樹, 日下 俊次.
    第134回南大阪勉強会  2019/07  大阪狭山市  近畿大学医学部眼科学教室
  • 小児無水晶体眼患者に処方したハードコンタクトレンズのベースカーブと度数の変化.
    立花 都子, 宮本 裕子, 月山 純子, 日下 俊次, 下村 嘉一.
    第62回日本コンタクトレンズ学会総会  2019/07  京都市, 国立京都国際会館  日本コンタクトレンズ学会
  • 培養で分離された菌種とは相違のあるメチシリン耐性菌による眼内炎の1例.
    大賀 智行, 堀田 芙美香, 石橋 眞里佳, 石橋 拓也, 江口 洋, 日下 俊次.
    第56回日本眼感染症学会  2019/07  京都市, 国立京都国際会館  日本眼感染症学会
  • 戻し電顕で遡及的に診断したMicrosporidia角膜炎.
    杉野 日彦, 江口 洋, 堀田 芙美香, 上野 覚, 福田 昌彦, 日下 俊次, 鈴木 崇, 木村 雅友, 八木田 健司.
    第56回日本眼感染症学会  2019/07  京都市, 国立京都国際会館  日本眼感染症学会
  • 次世代シークエンス技術を用いて診断したPasteurella科による線維柱帯切除術後眼内炎.
    石橋 眞里佳, 萱澤 朋泰, 堀田 芙美香, 奥山 幸子, 江口 洋, 日下 俊次.
    第56回日本眼感染症学会  2019/07  京都市, 国立京都国際会館  日本眼感染症学会
  • アカントアメーバ角膜炎の早期診断にPCRが有効であった一例.
    西田 功一, 福田 昌彦, 佐藤 朋子, 堀田 芙美香, 江口 洋, 日下 俊次.
    第56回日本眼感染症学会  2019/07  京都市, 国立京都国際会館  日本眼感染症学会
  • Surgery for Congenital X-linked Retinoschisis.  [Not invited]
    Kusaka S.
    19th European Vitreoretinal Society Meeting  2019/06  Lisbon, Portugal  EVRS
  • 片眼性後天赤緑異常の1例.
    大賀 智行, 國吉 一樹, 青松 圭一, 川崎 厚史, 日下 俊次.
    第67回日本臨床視覚電気生理学会  2019/06  墨田区, KFC Hall&Rooms  独立行政法人国立病院機構 東京医療センター 臨床研究センター(感覚器センター) 視覚研究部
  • 黄斑手術Ⅰ: 黄斑上膜・黄斑円孔  [Not invited]
    日下 俊次
    第18回硝子体手術ビデオセミナー  2019/06  港区, 東京コンファレンスセンター・品川  網膜硝子体手術研究会
  • 小児白内障の治療  [Not invited]
    日下 俊次
    第2回眼科手術Updateセミナー  2019/06
  • 〔特別講演〕難治性網膜疾患に対する治療  [Not invited]
    日下 俊次
    第78回近畿大学医学会学術講演会  2019/06  大阪狭山市, 近畿大学医学部  近畿大学医学会
  • 先天膜状白内障の手術症例
    上野 覚, 立花 都子, 四宮 加容, 日下 俊次
    第75回日本弱視斜視学会総会・第44回日本小児眼科学会総会合同学会  2019/06  アクトシティ浜松, 浜松市
  • 家族性滲出性硝子体網膜症に小頭症を合併した兄妹症例
    藤原 悦子, 日下 俊次, 瀬島 斉
    第75回日本弱視斜視学会総会・第44回日本小児眼科学会総会  2019/06  アクトシティ浜松, 浜松市
  • 間欠性外斜視の術後経過における斜視角の変化と融像幅の関係.
    成田 竜, 若山 曉美, 梅原 郁美, 歌村 圭介, 松本 富美子, 阿部 考助, 七部 史, 沼田 卓也, 日下 俊次.
    第75回日本弱視斜視学会総会・第44回日本小児眼科学会総会  2019/06  浜松市, アクトシティ浜松  日本弱視斜視学会
  • 先天性白内障の手術症例
    上野 覚, 立花 都子, 四宮 加容, 日下 俊次.
    第75回日本弱視斜視学会総会・第44回日本小児眼科学会総会  2019/06  浜松市, アクトシティ浜松  日本小児眼科学会
  • 近畿大学眼科におけるレーベル先天黒内障
    杉野 日彦, 國吉 一樹, 角田 和繁, 藤波 芳, 岩田 岳, 櫻本 宏之, 初川 嘉一, 日下 俊次.
    第75回日本弱視斜視学会総会・第44回日本小児眼科学会総会  2019/06  浜松市, アクトシティ浜松  日本小児眼科学会
  • Surgery in FEVR
    Kusaka S.
    Advances in Pediatric Retina Course 2019  2019/06  Salt Lake, USA
  • 〔Invited Faculty〕Management of FEVR  [Not invited]
    Kusaka S.
    Advance in Pediatric Retina Course  2019/06  Salt Lake City, USA
  • Vitrectomy for ROP
    Kusaka S
    2019 Korean Retina Society Annual Meeting (Seoul, Korea)  2019/06
  • 歯根部利用人工角膜 (OOKP) が有効であった瘢痕性角結膜障害の1例.
    武田 麻希, 西田 功一, 福田 昌彦, 高橋 彩, 江口 洋, 濱田 傑, 天野 史郎, 日下 俊次.
    第430回大阪眼科集談会  2019/06  大阪市  一般社団法人大阪府眼科医会
  • DRAM2関連網膜症の長期臨床経過
    近藤 千桜里, 國吉 一樹, 林 孝彰, 亀谷 修平, 片桐 聡, 久保田 大紀, 櫻本 宏之, 藤波 芳, 角田 和繁, 岩田 岳, 日下 俊次.
    第430回大阪眼科集談会  2019/06  大阪市  一般社団法人大阪府眼科医会
  • 〔特別講演〕未熟児網膜症の診断と治療  [Not invited]
    日下 俊次
    第8回大阪西部眼科病診連携の会  2019/06  大阪
  • 角膜実質細胞によるコラーゲンゲル収縮能におけるurokinase-tupe plasminogen activator(u-PA)の影響.
    西田 功一, 杉岡 孝二, 村上 純子, 岡田 清孝, 西田 輝夫, 日下 俊次.
    第51回日本結合組織学会学術大会  2019/06  東京都, KFCホール  日本結合組織学会
  • Surgical Treatment of Retinal Detachment Associated with Optic Disc Anomaly.  [Not invited]
    Kusaka S.
    Osaka Retina Meeting 2019  2019/05  コングレコンベンションセンター,大阪市  大阪網膜硝子体研究会
  • タブレット端末(ipad)を用いた簡易的な視野異常自己診断チェックシート(クワトロチャート)の有用性.
    石橋 眞里佳, 松本 長太, 奥山 幸子, 野本 裕貴, 七部 史, 萱澤 朋泰, 江浦 真理子, 日下 俊次
    第8回日本視野画像学会  2019/05  大阪市, 中央公会堂  日本視野画像学会
  • Heijl-Krakau法での固視不良応答に影響する要因の検討
    石橋 拓也, 野本 裕貴, 松本 長太, 七部 史, 奥山 幸子, 日下 俊次, 吉川 啓司.
    第8回日本視野画像学会  2019/05  大阪市, 中央公会堂  日本視野画像学会
  • 〔特別講演〕難治性網膜硝子体疾患への挑戦  [Not invited]
    日下 俊次
    第48回関西医科大学眼科同窓会 春の勉強会  2019/05  枚方市  関西医科大学眼科同窓会
  • The mechanism of phagocytosis induced by plasminogen on cultured corneal fibroblasts.
    Sato T, Sugioka K, Mishima H,Kusaka S, Nishida T.
    ARVO 2019 Annual Meeting  2019/05  Canada, Vancouver Convention Centre
  • Inhibition by Epigallocatechin Gallate of IL-1-Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts
    Sugioka K, Yoshida K, Murakami J, Itahashi M, Mishima H, Nishida T, Kusaka S.
    ARVO 2019 Annual Meeting  2019/05  Canada, Vancouver Convention Centre
  • Evaluation of fixation loss response to stimulation of physiologic scotoma by Heijl-Krakau method in eyes the deterioration of sensitivity near the physiologic scotoma.
    Ishibashi T, Matsumoto C, Nomoto H, Yoshikawa K, Nanno M, Okuyama, Tanabe F, Yamao S, Kimura S, Kusaka S.
    ARVO 2019 Annual Meeting  2019/04  Canada, Vancouver Convention Centre
  • Usefulness of a simplified self-checking tool(Quattro CHART)for visual field defects.
    Yamashita M, Matsumoto C, Okuyama S, Hashimoto S, Nomoto H,Tanabe F, Eura M, Kayazawa T, Kusaka S.
    ARVO 2019 Annual Meeting  2019/04  Canada, Vancouver Convention Centre
  • 未熟児網膜症に対するranibizumab硝子体内投与後の血清VEGF濃度.
    歌村 翔子, 國吉 一樹, 杉岡 孝二, 小西 悠平, 南方 俊祐, 和田 紀久, 日下 俊次.
    第123回日本眼科学会総会  2019/04  東京都, 国際フォーラム  公益財団法人日本眼科学会
  • 次世代シークエンス技術を用いた周術期の眼表面菌叢解析.
    堀田 芙美香, 江口 洋, 桑原 知巳, 今大路 治之, 日下 俊次.
    第124回日本眼科学会総会  2019/04  東京都, 国際フォーラム  公益財団法人日本眼科学会
  • マリオット盲点近傍に感度低下を有する眼におけるHeijl-Krakau法での固視不良応答.
    石橋 拓也, 松本 長太, 野本 裕貴, 奥山 幸子, 七部 史, 山雄 さやか, 吉川 啓司, 南野 麻美, 日下 俊次.
    第123回日本眼科学会総会  2019/04  東京都, 国際フォーラム  公益財団法日本眼科学会
  • 簡易的な視野異常自己診断チェックツール(クワトロチャート)の有用性.
    石橋 眞里佳, 松本 長太, 奥山 幸子, 橋本 茂樹, 野本 裕貴, 七部 史, 江浦 真理子, 萱澤 朋泰, 日下 俊次.
    第123回日本眼科学会総会  2019/04  東京都, 国際フォーラム  公益財団法人日本眼科学会
  • 新たな視野測定プログラムAIZE-EX
    野本 裕貴 , 松本 長太 , 吉川 啓司 , 南野 麻美 , 奥山 幸子 , 山雄 さやか , 木村 伸司 , 日下 俊次.
    第123回日本眼科学会総会  2019/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • レーベル先天黒内障
    杉野 日彦, 國吉 一樹, 角田 和繁, 藤波 芳, 岩田 岳, 櫻本 宏之, 初川 嘉一, 日下 俊次
    第429回大阪眼科集談会  2019/04  大阪市  一般社団法人大阪府眼科医会
  • 〔特別講演〕小児に対する白内障・硝子体手術  [Not invited]
    日下 俊次
    第429回大阪眼科集談会  2019/04  大阪市  一般社団法人大阪府眼科医会
  • Self-checking sheet (CLOCK CHART® Driving Edition) for binocular visual field defects  [Not invited]
    Ishibashi M, Matsumoto C, Hashimoto S, Okuyama S, Nomoto H, Eura M, Kayazawa T, Numata T, Kuniyoshi K, Kusaka S.
    8th World Glaucoma Congress  2019/03  Melbourne, Australia  World Glaucoma Association
  • Measurement of eye movement during stimulating to physiologic scotoma by Heijl-Krakau method with head-mounted perimeter imoⓇ.
    Ishibashi T, Matsumoto C, Okuyama S, Nomoto H, Tanabe F, Kayazawa T, Yamao S, Yoshikawa K, Kimura T, Asami N, Kusaka S.
    8th World Glaucoma Congress 2019  2019/03  Melbourne, Australia  World Glaucoma Association
  • 近畿大学眼科におけるレーベル先天黒内障.
    杉野 日彦, 國吉 一樹, 日下 俊次.
    第2回OHKKの会  2019/03  西宮市
  • 網膜芽細胞腫に伴う硝子体出血に対して硝子体手術を行った1例
    西田 功一, 日下 俊次, 今井 尚徳, 國吉 一樹, 森本 壮, 鈴木 茂伸.
    第2回OHKKの会  2019/03  西宮市
  • 近畿大学におけるデスメ膜内皮移植術(DMEK)の術後早期成績
    江口 洋, 大賀 智行, 堀田 芙美香, 日下 俊次
    第2回近畿アイNext  2019/03  堺市
  • 網膜疾患-最近の話題-  [Not invited]
    日下 俊次
    大阪府医師会医学会学術講演会  2019/03  大阪
  • Vitrectomy for Congenital X-linked Retinoschisis  [Not invited]
    Kusaka S.
    APAO 2019  2019/03  Bangkok, Thailand  APAO
  • Surgical Treatment of Retinal Detachment Associated with Morning Glory Syndrome  [Not invited]
    Kusaka S.
    APAO 2019  2019/03  Bangkok, Thailand  APAO
  • 〔特別講演〕硝子体手術~手術の進歩と難治性疾患へのアプローチ~  [Not invited]
    日下 俊次
    第74回徳島眼科研究会  2019/02  徳島市, ザ・グランドパレス  徳島大学眼科学分野
  • 〔特別講演〕硝子体手術の進歩と難治性疾患へのアプローチ  [Not invited]
    日下 俊次
    第24回大阪眼科手術シンポジウム  2019/02  大阪市, ザ・リッツカールトン大阪
  • Current treatment for complex retinal detachment.  [Not invited]
    Kusaka S.
    2019 Sino-Japan Ocular Fundus Disease Forum  2019/02  Shanghai, China
  • How We should Treat Retinal Detachment associated with Morning Glory Syndrome  [Not invited]
    Kusaka S.
    Vail Vitrectomy Meeting 2019  2019/02  Vail, USA
  • 表皮ブドウ球菌を保菌したアポクリン汗嚢腫
    杉野 日彦, 江口 洋, 堀田 芙美香, 福田 昌彦, 福田 さとり, 日下 俊次.
    角膜カンファレンス2019  2019/02  京都市, ウェスティン都ホテル京都  京都府立医科大学 眼科学教室
  • 近畿大学におけるデスメ膜内日移植術の術後早期成績
    大賀 智行, 江口 洋, 福田 さとり, 日下 俊次
    角膜カンファレンス2019  2019/02  京都市, ウェスティン都ホテル京都  京都府立医科大学 眼科学教室
  • 角膜穿孔、眼内炎と急激に進行した角膜ヘルペスの一例
    佐藤 朋子, 福田 昌彦, 西田 功一, 高橋 彩, 南 毅, 日下 俊次
    第428回大阪眼科集談会  2019/01  大阪市, オーバルホール  一般社団法人大阪府眼科医会
  • 角膜混濁例に対する硝子体手術  [Not invited]
    日下 俊次
    眼科コールドケース  2019/01  京都市
  • 〔Invited Speaker〕Intra- and Postoperative Complications of Vitrectomy for Stage 4A ROP  [Not invited]
    Kusaka S.
    The 12th Congress of Asia-Pacific Vitreo-Retina Society  2018/12  Seoul, Korea  Asia-Pacific Vitreo-retina Society (APVRS)
  • 重症未熟児網膜症(ROP)に対する抗血管内皮増殖因子(VEGF)治療後の再燃例の検討  [Not invited]
    歌村 翔子, 國吉 一樹, 初川 嘉一, 藤野 貴啓, 杉岡 孝二, 日下 俊次.
    第57回日本網膜硝子体学会総会  2018/12  京都市, 国立京都国際会館  日本網膜硝子体学会
  • 〔イブニングセミナー〕難治性網膜剥離に対する硝子体手術  [Not invited]
    日下 俊次
    第57回日本網膜硝子体学会総会  2018/12  京都市, 国立京都国際会館  日本網膜硝子体学会
  • 網膜芽細胞腫に伴う硝子体出血に対して硝子体手術を行った1例  [Not invited]
    西田 功一, 日下 俊次, 今井 尚徳, 國吉 一樹, 森本 壮, 鈴木 茂伸
    第57回日本網膜硝子体学会総会  2018/12  京都市, 国立京都国際会館  日本網膜硝子体学会
  • 青錐体1色覚の新規遺伝子変異  [Not invited]
    國吉 一樹, 林 孝彰, 岩佐 真紀, 山下 高廣, 上山 久雄, 片桐 聡, 櫻本 宏之, 宇野 直樹, 七田 芳則, 日下 俊次.
    第57回日本網膜硝子体学会総会  2018/12  京都市, 国立京都国際会館  日本網膜硝子体学会
  • 起炎菌の特定に苦慮した線維柱帯切除術後の細菌性眼内炎  [Not invited]
    石橋 眞里佳, 萱澤 朋泰, 堀田 芙美香, 奥山 幸子, 江口 洋, 日下 俊次
    第427回大阪眼科集談会  2018/12  大阪市  一般社団法人大阪府眼科医会
  • Luncheon Seminar:The experience of Optos Ultra-Widefield Imaging at Kindai University  [Not invited]
    Kusaka S.
    Annual Meeting of Taiwan Ophthalmological Soceity  2018/11  Taipei,Taiwan  Taiwan Ophthalmological Soceity
  • 〔Invited Speaker〕Treatment of Severe Coats’ Disease  [Not invited]
    Kusaka S.
    Annual Meeting of Taiwan Ophthalmological Soceity  2018/11  Taipei,Taiwan  Taiwan Ophthalmological Society
  • 〔特別講演〕未熟児網膜症の診断と治療  [Not invited]
    日下 俊次
    愛媛県眼科学術講演会  2018/11  松山市
  • 〔特別講演〕小児網膜硝子体疾患の診断と外科的治療  [Not invited]
    日下 俊次
    第20回兵庫県眼科フォーラム  2018/11  神戸市  兵庫県眼科医会
  • Systemic VEGF and Recurrence after Intravitreal Ranibizumab for ROP  [Not invited]
    Kusaka S, Sugioka K, Hiraki S, Kuniyoshi K, Konishi Y, Minakata S,Wada N.
    ROP Hot Topics 2018  2018/10  Chicago, USA
  • 先天網膜分離症に対する硝子体手術  [Not invited]
    岩田 明子,近藤 寛之,國吉 一樹,日下 俊次.
    第72回日本臨床眼科学会  2018/10  東京都, 国際フォーラム
  • 近畿大学におけるデスメ膜内皮移植術(DMEK)の術後早期成績  [Not invited]
    江口 洋, 大賀 智行, 堀田 芙美香, 日下 俊次.
    第426回大阪眼科集談会  2018/10  大阪市  一般社団法人大阪府眼科医会
  • 〔特別講演〕未熟児網膜症の診断と治療  [Not invited]
    日下 俊次
    第13回小児眼科診療セミナー  2018/09
  • DRAM2関連網膜症の臨床像とその長期経過  [Not invited]
    國吉 一樹,亀谷 修平,林 孝彰,櫻本 宏之,久保田 大紀,片桐 聡,藤波 芳,角田 和繁,岩田 岳,日下 俊次.
    第66回日本臨床視覚電気生理学会  2018/09  浜松市, アクトシティコングレスセンター  浜松医科大学 眼科学教室
  • imoにおけるアイトラッキング法とHeijl-Krakau法の比較  [Not invited]
    石橋 拓也, 松本 長太, 萱澤 朋泰, 奥山 幸子, 野本 裕貴, 七部 史, 山雄 さやか, 日下 俊次, 吉川 啓司, 木村 泰朗
    第29回日本緑内障学会  2018/09  新潟市, 朱鷺メッセ新潟コンベンションセンター  日本緑内障学会
  • 両眼CLOCK CHART Driving Editionの感度と再現性の検討  [Not invited]
    石橋 眞里佳, 松本 長太, 橋本 茂樹, 奥山 幸子, 野本 裕貴, 江浦 真理子, 萱澤 朋泰, 沼田 卓也, 日下 俊次
    第29回日本緑内障学会  2018/09  新潟市, 朱鷺メッセ新潟コンベンションセンター  日本緑内障学会
  • 進行緑内障症例における24plusと24-2測定点配置での中心10度内視野の比較  [Not invited]
    野本 裕貴, 松本 長太, 木村 泰朗, 奥山 幸子, 日下 俊次
    第29回日本緑内障学会  2018/09  新潟市, 朱鷺メッセ新潟コンベンションセンター  日本緑内障学会
  • ARC Course at EVRS  [Not invited]
    Embabi S, Kusaka S, Lam WC, Maia A, Michalewska Z, Nikolakopoulos A, Faia LJ, Wolfe J, Mahmoud T.
    18th EVRS Meeting  2018/08  Prague, Czech Republic
  • ARC Course at EVRS  [Not invited]
    Kusaka S.
    18th European VitreoRetinal Society Meeting  2018/08  Prague, Czech Republic  European VitreoRetinal Society
  • 角膜実質細胞の貪食能にプラスミノーゲンが与える影響  [Not invited]
    佐藤 朋子,杉岡 孝二,青松 圭一,髙橋 彩,三島 弘,西田 輝夫,日下 俊次.
    第22回眼創傷治癒研究会  2018/08  奈良市, 奈良ホテル  眼創傷治癒研究会
  • 角膜実質創傷治癒過程におけるalpha 2 antiplasminの役割  [Not invited]
    西田 功一, 杉岡 孝二, 村上 純子, 髙橋 彩, 岡田 清孝, 三島 弘, 日下 俊次.
    第22回眼創傷治癒研究会  2018/08  奈良市, 奈良ホテル  眼創傷治癒研究会
  • Ultra-wide field FA by oral fluorescein administration in pediatric patients.
    Kusaka S.
    The Third International Pediatric Vitreoretinal Diseases Summit Forum  2018/07  Shanghai, China
  • 未熟児網膜症に対する抗VEGF治療の現況  [Not invited]
    日下 俊次
    第35回日本眼循環学会  2018/07  松本市, ホテルブエナビスタ
  • Traumatic macular hole: To treat or not to treat.  [Not invited]
    Kusaka S.
    2018 Ocular TraumaCON  2018/07  Chennai, India  Ocular Trauma society
  • Intrascleral fixation of IOL using 2 needle technique  [Not invited]
    Kusaka S.
    2018 Ocular Trauma CON  2018/07  Chennai, India  Ocular Trauma society
  • Retinopathy of Prematurity (IPOSC) ROP Surgery  [Not invited]
    Kusaka S.
    World ophthalmology congress 2018  2018/06  Barcelona, Spain
  • 〔特別講演I〕 小児網膜硝子体疾患の診断と治療  [Not invited]
    日下 俊次
    福井県眼科医会学術講演会  2018/06  福井市  福井県眼科医会
  • 小児白内障手術におけるoptic capture法の有用性
    岩田 明子,立花 都子,阿部 考助,日下 俊次.
    第424回大阪眼科集談会  2018/06  大阪市, オーバルホール  一般社団法人大阪府眼科医会
  • 自動視野計による身体障害者等級の判定方法  [Not invited]
    萱澤 朋泰, 松本 長太, 奥山 幸子, 國吉 一樹, 橋本 茂樹, 野本 裕貴, 七部 史, 日下 俊次, 岩瀬 愛子
    第133回南大阪眼科勉強会  2018/05  大阪狭山市
  • 小児眼内レンズ挿入眼の両眼視機能に対する累進屈折力眼鏡の効果  [Not invited]
    武田 美夏, 松本 富美子, 日下 俊次
    第133回南大阪眼科勉強会  2018/05  大阪狭山市
  • 眼内レンズ挿入用カートリッジとシリコンチューブを用いたデスメ膜内皮移植術  [Not invited]
    堀田 芙美香, 江口 洋, 福田 昌彦, 日下 俊次
    第133回南大阪眼科勉強会  2018/05  大阪狭山市
  • 小児網膜、小児白内障  [Not invited]
    日下 俊次
    第17回硝子体手術ビデオセミナー  2018/05  港区, 東京コンファレンスセンター・品川  網膜硝子体手術研究会
  • Overview in Pediatric Retinal Disease.  [Not invited]
    Kusaka S.
    The 5th East Java Ophthalmology Workshop and Symposium  2018/05  Surabaya, Indonesia  East JAVA Indnesia Ophthalmologist assosiation
  • Intraoperative OCT for Various Retinal Diseases.  [Not invited]
    Kusaka S.
    The 5th East Java Ophthalmology Workshop and Symposium  2018/05  Surabaya, Indonesia  East JAVA Indnesia Ophthalmologist assosiation
  • ROP Management in Japan.  [Not invited]
    Kusaka S.
    The 5th East Java Ophthalmology Workshop and Symposium  2018/05  Surabaya, Indonesia  East JAVA Indnesia Ophthalmologist assosiation
  • Short-term perfluoro-n-octane (PFO) tamponade for complex retinal detachment  [Not invited]
    Kusaka S, Tsujioka D, Kuniyoshi K, Sugioka K, Shimomura Y.
    The Association for Research in Vision and Ophthalmology (ARVO) 2018  2018/05  Honolulu, USA  Association for Research in Vision and Ophthalmology
  • Efficacy of optic capture in pediatric cataract surgery without anterior vitrectomy.  [Not invited]
    Iwata A, Kusaka S, Tachibana K, Abe K, Tsujioka D, Shimomura Y.
    The Association for Research in Vision and Ophthalmology (ARVO) 2018  2018/04  Honolulu, USA  Association for Research in Vision and Ophthalmology
  • Plasminogen promotes phagocytic activity of cultured human corneal fibroblasts.
    Sato T, Sugioka K. Murakami J, Mishima H, Nishida T, Shimomura Y, Kusaka S.
    The Association for Research in Vision and Ophthalmology (ARVO) 2018  2018/04  Honolulu, USA  Association for Research in Vision and Ophthalmology
  • Investigation of the mechanism of onset of dacryocystitis after rebamipide ophthalmic solution administration.  [Not invited]
    Hotta F, Eguchi H, Hasegawa M, Miyazaki C, Hirose M, Taketani F, Sasaki T, Inoue Y, Shimomura Y, Kusaka S.
    The Association for Research in Vision and Ophthalmology (ARVO) 2018  2018/04  Honolulu, USA  Association for Research in Vision and Ophthalmology
  • Collagenolytic properties of Staphylococcus Aureus culture broth and staphylokinase on human corneal fibroblasts cultured in collagen gel.  [Not invited]
    Sugioka K, Kodama-Takahshi A, Sato T, Okada K, Murakami J, Park AM, Mishima H, Shimomura Y, Kusaka S, Nishida T.
    The Association for Research in Vision and Ophthalmology (ARVO) 2018  2018/04  Honolulu, USA  Association for Research in Vision and Ophthalmology
  • Investigation of the preoperative disturbances in the ocular surface micro biome using next-generation sequencing analysis  [Not invited]
    Eguchi H, Hotta F, Kuwahara T, Imaohji H, Kusaka S, Shimomura Y.
    The Association for Research in Vision and Ophthalmology(ARVO)2018  2018/05  Honolulu, USA  Association for Research in Vision and Ophthalmology
  • 座長:ランチョンセミナー17「エキスパートが語る、ZEISSの術中OCTとマーカーレスシステム」  [Not invited]
    日下 俊次
    第122回日本眼科学会総会  2018/04
  • 〔一般講演〕器官培養網膜色素上皮を用いた連続波、マイクロパルス波照射によるスポット面積の比較  [Not invited]
    日下 俊次
    第122回日本眼科学会総会  2018/04
  • 硝子体手術を行った重症Coats病の視機能予後  [Not invited]
    立花 都子, 日下 俊次, 阿部 考助, 辻岡 大志, 國吉 一樹, 下村 嘉一.
    第423回大阪眼科集談会  2018/04  大阪市  一般社団法人大阪府眼科医会
  • Intraoperative OCT findings in Retinal Detachment Surgery.  [Not invited]
    Kusaka S.
    Frankfurt Retina Meeting 2018  2018/03  Frankfurt, Germany
  • My Way of Treating Severe Coats' Disease  [Not invited]
    Kusaka S.
    Frankfurt Retina Meeting  2018/03  Frankfurt, Germany
  • 小児難治性網膜疾患に対する外科的治療  [Not invited]
    日下 俊次
    Retina Update Spring Seminar  2018/03  大阪市
  • Surgery RightBroadcast from St.Petersburg Branch Mntk "Eye microsurgery"  [Not invited]
    Kusaka S, Shkvorchebko D.O, Black D.V
    Modern Technologies in Vitreoretinal Pathology Treatment  2018/03
  • Vitrectomy and/or anti- VEGF treatment for ROP.  [Not invited]
    Kusaka S.
    Modern technologies of treatment of vitreoretinal Pathology-2018  2018/03  Saint Petersburg, Russia
  • Approach to the treatment of familial exudative vitreoretinopathy.  [Not invited]
    Kusaka S.
    Modern technologies of treatment of vitreoretinal Pathology-2018  2018/03  Saint Petersburg, Russia
  • Apprach to the treatment of family hereditary exudative Pvr  [Not invited]
    Kusaka S.
    Modern Technologies in Vitreoretinal Pathology Treatment  2018/03  Saint Petersburg, Russia
  • [Morning Meeting]New technologies and reserch in vitreoretinal pathology  [Not invited]
    Zakharov V, Shkvorchebko D.O, Samoilov A.N, Kulikov A.N, Colin A.b, Kusaka S, Seth V, Sdobnikova S.
    Modern Technologies in Vitreoretinal Pathology Treatment  2018/03  Saint Petersburg, Russia
  • Visual outcome after vitrectomy for severe Coats' disease  [Not invited]
    Tachibana K, Kusaka S, Abe K, Tujioka D, Kuniyoshi K, Shimomura Y.
    第43回日本小児眼科学会総会  2018/03  名古屋市, ウインクあいち
  • 小児疾患への画像診断への活用  [Not invited]
    日下 俊次, 坂本 泰二.
    第43回日本小児眼科学会総会  2018/03  名古屋市, ウインクあいち  日本小児眼科学会 寺﨑 浩子(名古屋大学)
  • 小児白内障手術におけるoptic capture法の有用性の検討  [Not invited]
    岩田 明子, 日下 俊次, 立花 都子, 阿部 考助, 辻岡 大志, 下村 嘉一.
    第43回日本小児眼科学会総会  2018/03  名古屋市, ウインクあいち
  • 治療のアップデート 硝子体手術  [Not invited]
    日下 俊次
    第43回日本小児眼科学会総会  2018/03  名古屋市, ウインクあいち
  • 〔特別講演〕小児網膜疾患の治療  [Not invited]
    日下 俊次
    第51回奈良県眼科医会学術定例会  2018/02  奈良市  奈良県眼科医会
  • 眼内レンズ挿入用カートリッジとシリコンチューブを用いた DMEK  [Not invited]
    堀田 芙美香, 江口 洋, 日下 俊次, 福田 昌彦, 下村 嘉一
    角膜カンファランス2018  2018/02  広島市, グランドプリンスホテル広島  広島大学大学院視覚病態学(眼科学)
  • Surgical Treatment of Retinopathy of Prematurity  [Not invited]
    Kusaka S.
    The 33rd APAO Congress  2018/02  Hong Kong
  • New Surgical Techniques in the Management of Pediatric Retinal Diseases (ROP, FEVR, Coats’)  [Not invited]
    Kusaka S.
    The 33rd APAO Congress  2018/02  Hong Kong
  • Vitrectomy for Stage 4 and 5 ROP  [Not invited]
    Kusaka S
    Vietnam ROP Workshop  2018/02  Ho Chi Minh, Vietnam
  • Intravitreal ranibizumab: serum VEGF concentration change and recurrence rate(as compared with bevacizumab)  [Not invited]
    Kusaka S.
    Vietnam ROP Workshop  2018/02  Ho Chi Minh, Vietnam
  • Diagnosis and treatment of retinopathy of prematurity  [Not invited]
    Kusaka S.
    Surgical retina, Retina Eye Care of Nepal (RECON) meeting 2018  2018/01  Pokhara, Nepal  Retina Eye Care of Nepal (RECON)
  • Diagnosis and treatment of retinopathy of prematurity  [Not invited]
    Kusaka S.
    Surgical retina, Retina Eye Care of Nepal (RECON) meeting 2018  2018/01  Kathmandu, Nepal.  Retina Eye Care of Nepal (RECON)
  • 〔特別講演〕小児網膜硝子体疾患の診断と治療  [Not invited]
    日下 俊次
    第29回やまぐち眼科フォーラム  2018/01  山口市, 山口グランドホテル
  • Surgical Intervention in ROP: Indications and Outcomes.  [Not invited]
    Kusaka S.
    The 11th APVRS/Congress of APVRS 2017  2017/12  Kuala Lumpur, Malaysia  APVRS・Malaysian socienty of Ophthalmology
  • Short-term perfluoro-n-octane (PFO) tamponade for complex retinal detachment.  [Not invited]
    Tsujioka D, Kusaka S, Sugioka K, Kuniyoshi K, Shimomura Y.
    The 2ndTaiwan-Japan Joint Meeting  2017/12  東京都
  • 再燃を繰り返し、長期に渡る治療を要したvon Hippel-Lindau病の1例  [Not invited]
    立花 都子, 日下 俊次, 辻岡 大志, 下村 嘉一.
    第56回日本網膜硝子体学会総会  2017/12  千代田区, 東京国際フォーラム  日本網膜硝子体学会
  • Surgical treatment of pediatric complex retinal detachment  [Not invited]
    Kusaka S.
    第56回日本網膜硝子体学会総会  2017/12  千代田区, 東京国際フォーラム  日本網膜硝子体学会
  • 小児網膜硝子体疾患の治療
    日下 俊次
    神戸大学オープンカンファレンス  2017/11  神戸大学
  • 〔特別講演〕小児網膜硝子体疾患の診断と治療  [Not invited]
    日下 俊次
    第5回Senju Ophthalmic Seminar in 岡山 ~網膜硝子体を網羅する~  2017/10  岡山  千寿製薬株式会社
  • 〔特別講演〕中高年の網膜疾患 糖尿病網膜症と加齢黄斑変性  [Not invited]
    日下 俊次
    目の愛護デー講座  2017/10  秋田市  秋田県眼科医会
  • パーフルオロ-n-オクタン(PFO)短期留置を行った硝子体手術成績  [Not invited]
    辻岡 大志, 日下 俊次, 杉岡 孝二, 國吉 一樹, 下村 嘉一.
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • 〔モーニングセミナー〕網膜剥離-私のtrend-  [Not invited]
    日下 俊次
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • Corynebacterium simulans 角膜炎  [Not invited]
    堀田 芙美香, 江口 洋, 武田 純爾, 日下 俊次, 桑原 知巳, 今大路 治之, 宮本 龍郎, 福田 昌彦, 下村 嘉一
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • 生後早期の硝子体手術で黄斑牽引が改善した家族性滲出性硝子体網膜症の1例  [Not invited]
    岩田 明子, 日下 俊次, 石丸 真弓, 近藤 寛之, 國吉 一樹, 下村 嘉一.
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • レバミピド点眼後の涙嚢炎発生機序に関する研究  [Not invited]
    長谷川 麻里子, 江口 洋, 堀田 芙美香, 日下 俊次, 宮崎 千歌, 廣瀬 美央, 竹谷 太, 佐々木 次壽, 井上 康, 下村 嘉一.
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • 〔シンポジウム〕術中OCT -特に小児手術における有用性-  [Not invited]
    日下 俊次
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • 〔イブニングセミナー〕レチナナイトメア ~最後の聖戦~  [Not invited]
    日下 俊次
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • 〔インストラクションコース〕網膜剥離ファイトクラブ round13-症例をシェアして自分のものにする  [Not invited]
    日下 俊次
    第71回日本臨床眼科学会  2017/10  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会・公益社団法人日本眼科医会
  • Vitrectomy for Severe Coats Disease  [Not invited]
    Kusaka S.
    硝子体手術講習会  2017/09  港区, 虎ノ門ヒルズフォーラム  硝子体手術講習会・日本アルコン株式会社
  • Debate 1:ILM transplantation  [Not invited]
    Kusaka S.
    硝子体手術講習会  2017/09  港区, 虎ノ門ヒルズフォーラム  硝子体手術講習会・日本アルコン株式会社
  • Panel Discussion 1:Case presentation  [Not invited]
    Kusaka S.
    硝子体手術講習会  2017/09  港区, 虎ノ門ヒルズフォーラム  硝子体手術講習会・日本アルコン株式会社
  • チャレンジ!小児網膜硝子体疾患  [Not invited]
    日下 俊次
    第23回網膜硝子体セミナー  2017/09  東京都
  • Current treatment for severe Coats disease  [Not invited]
    Kusaka S.
    17th EURETINA Congress  2017/09  Barcelona, Spain
  • ROPに対するranibizumab – update–  [Not invited]
    日下 俊次
    Japan Macula Club 第19回学術講演会  2017/08  蒲生
  • MRワクチン接種後に発症した重篤な視細胞変性  [Not invited]
    佐藤 朋子, 國吉 一樹, 初川 嘉一, 木村 貞美, 藤野 貴啓, 大黒 浩, 中井 理恵, 角南 健太, 三島 壮一郎, 日下 俊次, 鈴木 保宏, 下村 嘉一.
    第419回大阪眼科集談会  2017/08  大阪市, オーバルホール  一般社団法人大阪府眼科医会
  • 〔特別講演〕未熟児網膜の診断と治療update  [Not invited]
    日下 俊次
    第6回眼科医療の未来を考える会  2017/08  大阪
  • 小児片眼性無水晶体眼に対するコンタクトレンズ処方の検討  [Not invited]
    立花 都子, 宮本 裕子, 月山 純子, 阿部 考助, 日下 俊次, 下村 嘉一.
    第60回日本コンタクトレンズ学会総会  2017/07  大阪市, 大阪国際会議場  日本コンタクトレンズ学会
  • Intraoperative OCT  [Not invited]
    Kusaka S.
    RETINA SUMMIT 2017  2017/07  Chennai, India
  • Vitrectomy vs external drainage in Coat’s disease with RD  [Not invited]
    Kusaka S.
    RETINA SUMMIT 2017  2017/07  Chennai, India
  • RD with FEVR  [Not invited]
    Kusaka S.
    RETINA SUMMIT 2017  2017/07  Chennai, India
  • Intrascleral fixation of IOL using 2 needle technique  [Not invited]
    KUSAKA Shunji
    Ocular TraumaCon 2018 meeting in Chennai  2017/07
  • 小児家族性滲出性硝子体網膜症に対する硝子体手術  [Not invited]
    辻岡 大志, 立花 都子, 岩田 明子, 日下 俊次.
    第6回なんかい眼科フォーラム  2017/07  大阪
  • 〔モーニングセミナー〕小児網膜疾患・治療の実際  [Not invited]
    〔モーニングセミナー〕小児網膜疾患・治療の実際
    第42回日本小児眼科学会総会・第73回日本弱視斜視学会総会  2017/06  金沢市, 石川県立音楽堂  日本小児眼科学会総会・日本弱視斜視学会総会
  • 裂孔併発し治療に難渋した重症Coats病の1例  [Not invited]
    辻岡 大志, 日下 俊次, 立花 都子, 高井 保幸, 下村 嘉一.
    第42回日本小児眼科学会総会・第73回日本弱視斜視学会総会  2017/06  金沢市, 石川県立音楽堂  日本小児眼科学会総会・日本弱視斜視学会総会
  • 小児無水晶体眼に対するコンタクトレンズ処方  [Not invited]
    立花 都子, 日下 俊次, 阿部 考助, 國吉 一樹, 辻岡 大志, 宮本 裕子, 下村 嘉一.
    第42回日本小児眼科学会総会・第73回日本弱視斜視学会総会  2017/06  金沢市, 石川県立音楽堂  日本小児眼科学会・日本弱視斜視学会
  • Intraoperative OCT in Pediatric Eye Disease  [Not invited]
    Kusaka S.
    4th Intraoperative OCT Science Day  2017/06  Barcelona, Spain
  • 水晶体関連  [Not invited]
    日下 俊次
    第16回硝子体手術ビデオセミナー  2017/05  東京都
  • Corynebacterium oculiの薬剤感受性.  [Not invited]
    堀田 芙美香, 江口 洋, 日下 俊次, 福田 昌彦, 下村 嘉一, 今大路 治之, 桑原 知巳, Bernard KA, Vandamme P.
    第121回日本眼科学会総会  2017/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • 小児でのToric IOL使用成績とoptic captureの影響  [Not invited]
    立花 都子, 日下 俊次, 阿部 考助, 辻岡 大志, 堀田 芙美香, 江口 洋, 下村 嘉一.
    第121回日本眼科学会総会  2017/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • 術前眼表面の培養結果と分離菌のキノロン感受性  [Not invited]
    西田 功一, 江口 洋, 堀田 芙美香, 立花 都子, 辻岡 大志, 日下 俊次, 福田 昌彦, 下村 嘉一.
    第121回日本眼科学会総会  2017/04  千代田区, 東京国際フォーラム  公益財団法人日本眼科学会
  • Intraoperative OCT Findings in Complex VR Surgery  [Not invited]
    Kusaka S.
    ZEISS RESCAN 700 focus meeting  2017/04  東京都
  • 重症未熟児網膜症に対するranibizumab硝子体内投与  [Not invited]
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 小西 悠平, 南方 俊祐, 和田 紀久, 松本 長太, 下村 嘉一.
    第417回大阪眼科集談会  2017/04  大阪市, オーバルホール  一般社団法人大阪府眼科医会
  • Surgical Treatment of FEVR  [Not invited]
    Kusaka S.
    The 2nd Retina and Glaucoma Symposium  2017/03  Lodz, Poland
  • Surgical and/or anti-VEGF treatment of Severe ROP  [Not invited]
    Kusaka S.
    The 2nd Retina and Glaucoma Symposium  2017/03  Lodz, Poland
  • Surgical Panel Discussion  [Not invited]
    Kusaka S.
    The 2nd Retina and Glaucoma Symposium  2017/03  Lodz, Poland
  • Intraoperative OCT Findings in Complex VR Surgery  [Not invited]
    Kusaka S.
    The 2nd Retina and Glaucoma Symposium  2017/03  Lodz, Poland
  • 小児硝子体手術でのコツと技  [Not invited]
    日下 俊次
    Osaka Retina Meeting 2017  2017/03  大阪市, コングレコンベンションセンター(グランフロント大阪 ナレッジキャピタル B2F)  大阪網膜硝子体研究会
  • Pediatric Retina Surgery /Intraoperative OCT Findings in Pediatric Vitreoretina Surgery.  [Not invited]
    Kusaka S.
    APAO Congress 2017  2017/03  Singapore
  • Surgical ROP/Pediatric Case Discussion.  [Not invited]
    Kusaka S, Quiroz-Mercado H, Moshfeghi DM, Sears J. PANE
    Retina World Congress 2017  2017/02  Florida, USA.
  • 裂孔を伴ったCoats病に対する手術  [Not invited]
    日下 俊次
    硝子体フォーラムWinter Vitrectomy Meeting  2017/02  虻田郡
  • 〔Educational presentation〕 小児の硝子体手術  [Not invited]
    日下 俊次
    The 1st meeting VRNetwork  2017/01  東京都
  • 難治性眼疾患への挑戦  [Not invited]
    日下 俊次
    大阪大学医学部薬理学教室同窓会総会・講演会  2017/01  大阪
  • Coats Disease in Children—Do We Have Effective Strategies to Improve the Visual Outcome?  [Not invited]
    Kusaka S.
    The 10th Congress of the Asia-Pacific Vitreo-retina Society  2016/12  Bangkok, Thailand
  • Surgery for Coats Disease.  [Not invited]
    Kusaka S.
    The 10th Congress of the Asia-Pacific Vitreo-retina Society  2016/12  Bangkok, Thailand
  • 重症未熟児網膜症に対するranibizumab硝子体内投与  [Not invited]
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 小西 悠平, 南方 俊祐, 和田 紀久, 松本 長太, 下村 嘉一.
    第55回日本網膜硝子体学会総会  2016/12  渋谷区, ベルサール渋谷ガーデン
  • 滲出性網膜剥離を来したCoats病に対する手術成績  [Not invited]
    辻岡 大志, 日下 俊次, 立花 都子, 初川 嘉一, 今泉 綾子, 兒玉 達夫, 下村 嘉一.
    第55回日本網膜硝子体学会総会  2016/12  渋谷区, ベルサール渋谷ガーデン
  • 1歳男児に急性発症した重篤な網膜機能傷害  [Not invited]
    佐藤 朋子, 國吉 一樹, 下村 嘉一, 初川 嘉一, 藤野 貴啓, 角南 健太, 木村 貞美, 大黒 浩, 三島 壮一郎, 日下 俊次.
    第127回南大阪眼科勉強会  2016/11  大阪狭山市  近畿大学医学部眼科学教室
  • 2次元電気泳動法による未熟児網膜症患者の硝子体中タンパク質のプロテオーム解析  [Not invited]
    杉岡 孝二, 日下 俊次, 斎藤 昭夫, 國吉 一樹, 下村 嘉一.
    第70回日本臨床眼科学会  2016/11  京都市, 国立京都国際会館
  • レバミピド点眼薬による涙嚢炎での涙石の検討  [Not invited]
    竹谷 太, 江口 洋, 宮崎 千歌, 長谷川 麻里子, 廣瀬 美央, 日下 俊次, 福田 昌彦, 下村 嘉一.
    第70回日本臨床眼科学会  2016/11  京都市, 国立京都国際会館
  • 涙嚢分泌物の培養と次世代シークエンス解析の比較検討  [Not invited]
    堀田 芙美香, 江口 洋, 宮崎 千歌, 杉本 学, 今大路 治之, 桑原 知巳, 日下 俊次, 下村 嘉一.
    第70回日本臨床眼科学会  2016/11  京都市, 国立京都国際会館
  • ステロイド投与が奏功した肺炎球菌角膜炎の1例  [Not invited]
    佐藤 朋子, 江口 洋, 堀田 芙美香, 日下 俊次, 福田 昌彦, 下村 嘉一.
    第70回日本臨床眼科学会  2016/11  京都市, 国立京都国際会館
  • Stickler症候群では高率に黄斑低形成を合併する  [Not invited]
    松下 五佳, 永田 竜朗, 林 孝彰, 木許 賢一, 久保田 敏昭, 大路 正人, 日下 俊次, 近藤 寛之.
    第70回日本臨床眼科学会  2016/11  京都市, 国立京都国際会館
  • 網膜剥離ファイトクラブ round 12 −症例をシェアして自分のものにする−  [Not invited]
    喜多 美穂里, 大島 佑介, 門之園 一明, 木村 英也, 日下 俊次, 栗山 昌治, 竹内 忍.
    第70回日本臨床眼科学会  2016/11  京都市, 国立京都国際会館
  • 無虹彩・無硝子体眼での内皮移植片縫着DSAEKの早期成績  [Not invited]
    西田 功一, 江口 洋, 堀田 芙美香, 辻岡 大志, 立花 都子, 日下 俊次, 福田 昌彦, 下村 嘉一.
    第70回日本臨床眼科学会  2016/11  京都市, 国立京都国際会館
  • 【特別講演Ⅱ】チャレンジ!小児網膜硝子体疾患  [Not invited]
    日下 俊次
    第6回山形眼科フォーラム  2016/10  山形市
  • Foveal Hypoplasia in Patients with Stickler Syndrome.  [Not invited]
    Matsushita I, Hayashi T, Kimoto K, Kubota T, Ohji M, Kusaka S, Kondo H.
    American Academy of Ophthalmology (AAO) 2016  2016/10  Chicago, USA
  • 水晶体再建術後に良好な視機能が得られた小児マルファン症候群の一例
    百海 紗弥香, 阿部 考助, 日下 俊次, 立花 都子, 松本 富美子, 田中 玲湖, 西岡 由加里, 飯尾 早也香, 萱澤 真梨子, 三島 弘.
    第57回日本視能矯正学会  2016/10  大阪
  • 〔シンポジウム〕1 歳男児に急性発症した重篤な網膜機能障害
    佐藤 朋子, 園吉 一樹, 初川 嘉一, 木村 貞美, 藤野 貴啓, 角南 健太, 大黒 浩, 三島 壮一郎, 日下 俊次, 下村 嘉一.
    第64回日本臨床視覚電気生理学会  2016/09  伊勢市, 伊勢志摩ロイヤルホテル
  • New device to prevent moisture condensation on non-contact wide-field viewing system.  [Not invited]
    Kusaka S, Tachibana K, Shimomura Y.
    16th Euretina Congress  2016/09  Copenhagen, Kingdom of Denmark
  • ROPに対するIVR  [Not invited]
    日下 俊次
    Japan Macula Club 第18回学術講演会  2016/08  大阪市
  • How to Deal with FEVR.  [Not invited]
    Kusaka S.
    The Second International Pediatric Vitreoretinal Diseases Summit Forum  2016/08  Shanghai, China
  • Lens Clarity after Lens-sparing Vitrectomy for ROP.  [Not invited]
    Kusaka S.
    The Second International Pediatric Vitreoretinal Diseases Summit Forum  2016/08  Shanghai, China
  • Intraoperative OCT Findings in Pediatric VR Surgry.  [Not invited]
    Kusaka S.
    The Second International Pediatric Vitreoretinal Diseases Summit Forum  2016/08  Shanghai, China
  • Ultra-Wide Field FA by Orel Fluorescein Administration in Pediatric Patients.  [Not invited]
    Kusaka S.
    The Second International Pediatric Vitreoretinal Diseases Summit Forum  2016/08  Shanghai, China
  • 近畿大学堺病院の最近の手術の動向  [Not invited]
    日下 俊次
    第5回なんかい眼科フォーラム  2016/07  大阪市
  • モキシフロキサシン角膜実質注射が有効で合ったMoraxella catarrhalis 角膜炎の一例.
    平木 翔子, 江口 洋, 立花 都子, 米田 早織, 堀田 芙美香, 桑原 和巳, 日下 俊次, 福田 昌彦, 下村 嘉一.
    第53回日本眼感染症学会  2016/07  千代田区, 東京国際フォーラム
  • 多剤耐性・バイオフィルム低産生Staphylococus haemolyticusによるinfectious crystalline keratopathy.
    山下 眞里佳, 宮本 龍郎, 江口 洋, 米田 早織, 堀田 芙美香, 桑原 知巳, 日下 俊次, 福田 昌彦, 下村 嘉一.
    第53回日本眼感染症学会  2016/07  千代田区, 東京国際フォーラム
  • 小児網膜疾患に対する両眼同日手術
    辻岡 大志, 日下 俊次, 園吉 一樹, 杉岡 孝二, 下村 嘉一.
    第41 回日本小児眼科学会総会・第72 回日本弱視斜視学会総会  2016/06  横浜市
  • 小児白内障に対するトーリック眼内レンズ挿入眼の術後視機能  [Not invited]
    立花 都子, 日下 俊次, 阿部 孝助, 辻岡 大志, 小池 英子, 江口 洋, 下村 嘉一.
    第41回日本小児眼科学会総会 第72回日本弱視斜視学会総会  2016/06  横浜市
  • 〔教員セミナー〕眼底検査  [Not invited]
    日下 俊次
    第41回日本小児眼科学会総会 第72回日本弱視斜視学会総会  2016/06  横浜市
  • 近畿大学における眼科臨床分離株の各種抗菌薬に対する感受性
    堀田 芙美香, 江口 洋, 日下 俊次, 立花 都子, 辻岡 大志, 福田 昌彦, 下村 嘉一.
    第14 回Symposium of Ocular Surface and Infection  2016/05  大阪市
  • チャレンジ!小児サージカルレチナ  [Not invited]
    日下 俊次
    β(ベータ)の会  2016/05  横浜市
  • 難治性網膜硝子体疾患の外科的治療  [Not invited]
    日下 俊次
    第3回アイリーア&エタニティーアップデートセミナー in 大分  2016/05  大分市
  • ROP Treatment  [Not invited]
    Kusaka S.
    13th International Congress of the Middle East Africa Council of Ophthalmology  2016/05  Manama, Bahrain
  • Roles of Genes in Phenotypic Diversity and Intraocular Asymmetry in Patients with Familial Exudative Vitreoretinopathy.  [Not invited]
    Kondo H, Uchio E, Hayashi T, Nishina S, Azuma N, Kusaka S.
    The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) 2016  2016/05  Seattle, USA
  • 〔特別講演〕難治性網膜硝子体疾患の治療
    日下 俊次.
    第65回愛媛県眼科集談会  2016/04  愛媛  一般社団法人愛媛県眼科医会
  • 小児裂孔原性網膜剥離
    日下 俊次
    第120回日本眼科学会総会  2016/04  仙台市, 仙台国際センター
  • 角膜移植術における術中 real-time OCT (RESCAN�� 700)  [Not invited]
    江口 洋, 小池 英子, 立花 都子, 辻岡 大志, 日下 俊次, 福田 昌彦, 下村 嘉一.
    第120回日本眼科学会総会  2016/04  仙台市, 仙台国際センター
  • 未熟児網膜症に対する水晶体温存硝子体術後の水晶体透明性  [Not invited]
    立花 都子, 日下 俊次, 阿部 考助, 森本 壮, 國吉 一樹, 杉岡 孝二, 岩橋 千春, 不二門 尚, 下村嘉一.
    第120回日本眼科学会総会  2016/04  仙台市, 仙台国際センター、東北大学(川内キャンパス)
  • 先天性網膜接着不全症候群およびFEVR患者におけるATOH7遺伝子異常  [Not invited]
    松下五佳; 内尾英一; 日下俊次; 近藤寛之
    第120回日本眼科学会総会  2016/04  仙台市
  • 未熟児網膜症に対する水晶体温存硝子体術後の水晶体透明性
    立花 都子, 日下 俊次, 阿部 考助, 森本 壮, 國吉 一樹, 杉岡 孝二, 岩橋 千春, 不二門 尚, 下村 嘉一.
    第411回大阪眼科集談会  2016/04  大阪市  一般社団法人大阪府眼科医会
  • Intra-operative OCT in Various Complex Vitreous Surgery.  [Not invited]
    Kusaka S.
    3rd Intra-Operative OCT Science Day  2016/04  Paris, France
  • Early Surgical Treatment of FEVR  [Not invited]
    Kusaka S.
    Association of Pediatric Retinal Surgeons Meeting 2016  2016/03  Los Cabos, Mexico
  • Late Complications of Vitrectomy for ROP  [Not invited]
    Kusaka S.
    Aaia-Pacific Academy of Ophthalmology Meeting 2016  2016/03  Taipei,Taiwan
  • the Congress Centrum  [Not invited]
    Kusaka S.
    Frankfurt Retina Meeting 2016  2016/03  Frankfurt, Germany
  • 【特別講演】小児の眼底疾患  [Invited]
    日下 俊次
    第93回岡山大学眼科研究会  2016/03  岡山市
  • 【特別講演】小児網膜硝子体疾患の診断と治療  [Not invited]
    日下 俊次
    第17回山梨網膜研究会  2016/03  甲府市
  • 【特別講演】小児網膜硝子体疾患の診断と治療  [Invited]
    日下 俊次
    第9回東京眼科アカデミー  2016/02  千代田区, ザキャピトルホテル東急  東京眼科アカデミー/日本アルコン株式会社
  • Surgical Results of FEVR  [Not invited]
    Kusaka S.
    Vail Vitrectomy Meeting 2016  2016/02  Colorado, USA
  • Anti-VEGF and/or Vitrectomy for Severe Coats Disease  [Not invited]
    Kusaka S.
    RETINA SYMPOSIUM : Organized by TIO/Nepal Ophthalmic Society (NOS)  2015/12  Kathmandu, Nepal
  • 第409回大阪眼科集談会
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 下村 嘉一, 近藤 寛之.
    先天網膜分離症に硝子体手術を施行した1例  2015/12  大阪市  一般社団法人大阪府眼科医会
  • The surgical outcomes of vitrectomy for stage 5 retinopathy of prematurity
    Tachinaba K, Kusaka S, Abe K, Kuniyoshi K, Sugioka K, Iwasaki C, Morimoto T, Fujikado F, Shimomura Y.
    第54 回日本網膜硝子体学会総会・第32 回日本循環学会 合同学会  2015/12  千代田区, 東京国際フォーラム  日本網膜硝子体学会・日本循環学会
  • 〔イブニングセミナー〕「私が選んだ硝子体手術マシン」-弘法も筆を選ぶ!?-  [Not invited]
    日下 俊次
    第54回日本網膜硝子体学会総会・第32回日本循環学会 合同学会  2015/12  千代田区, 東京国際フォーラム 第3会場(ホールB7(2))  日本網膜硝子体学会・日本循環学会
  • Late complications of Vitrectomy for ROP  [Not invited]
    Kusaka S.
    RETINA SYMPOSIUM : Organized by TIO/Nepal Ophthalmic Society (NOS)  2015/12  Kathmandu, Nepal
  • Long-term Surgical Results of Stage 4A (and/or Stage 5) ROP  [Not invited]
    Kusaka S.
    RETINA SYMPOSIUM : Organized by TIO/Nepal Ophthalmic Society (NOS)  2015/12  Kathmandu, Nepal
  • Advances in Vitreoretinal Surgery  [Not invited]
    Kusaka S.
    American Academy of Ophthalmology2015  2015/11  Vas Legas, USA
  • インストラクションコース 網膜剥離ファイトクラブ 第11ラウンド-症例をシェアして自分のものにする2-  [Not invited]
    喜多 美穂里, 大島 佑介, 門之園 一明, 木村 英也, 日下 俊次, 栗山 昌治, 竹内 忍.
    第69回日本臨床眼科学会  2015/10  名古屋市, 名古屋国際会議場・ANAクラウンホテルプラザホテルグランコート名古屋
  • 重症未熟児網膜症に対してranibizumab 硝子体内投与を施行した3 症例
    平木 翔子, 杉岡 孝二, 國吉 一樹, 日下 俊次, 下村 嘉一.
    第123 回南大阪眼科勉強会  2015/10  大阪狭山市  近畿大学医学部眼科学教室
  • 重症未熟児網膜症に対して ranibizumab 硝子体内投与を施行した3 症例.
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 松本 長太, 下村 嘉一.
    第408 回大阪眼科集談会  2015/10  大阪市  一般社団法人大阪府眼科医会
  • 小児網膜硝子体疾患の診断と治療  [Not invited]
    日下 俊次
    第9回北陸オフサルミックフォーラム  2015/10  金沢市
  • 小児網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第11回武庫川眼科アカデミー  2015/10  尼崎市
  • 先天網膜分離症に硝子体手術 を施行した1例.
    平木 翔子, 日下 俊次, 杉岡 孝二, 國吉 一樹, 下村 嘉一, 近藤 寛之.
    大阪眼科手術の会  2015/09  大阪
  • Treatment of severe Coats disease by anti-VEGF therapy and/or vitrectomy  [Not invited]
    Kusaka S.
    The 3rd World Congress of Paediatric Ophthalmology and Strabismus  2015/09  Barcelona, Spain  The World Society of Paediatric Ophthalmology and Strabismus
  • The use of iOCT for the evaluation of macular status in vitrectomy for PDR  [Not invited]
    Kusaka S.
    RESCAN 700 Expert User Meeting ESCRS 2015  2015/09  Barcelona, Spain
  • 新たに製作したRed filter ladderを用いた斜位の維持能力の評価
    高田 遼太, 松本 富美子, 立花 都子, 日下 俊次, 若山 暁美, 児島 理恵, 七部 史, 下村 嘉一, 百海 沙弥香, 阿部 考助, 石場 義久.
    第122回南大阪眼科勉強会  2015/08  大阪狭山市  近畿大学医学部眼科学教室
  • FEVRに対する硝子体手術  [Not invited]
    日下 俊次
    Japan Macula Club 第17回学術講演会  2015/08  蒲郡市
  • 経口フルオレセインを用いた超広角眼底撮影の試み
    辻岡 大志, 日下 俊次, 髙田 遼太, 松本 富美子, 立花 都子, 小池 英子, 江口 洋, 下村 嘉一.
    第71回日本弱視斜視学会総会第40回日本小児眼科学会合同学会  2015/07  神戸市, 神戸ポートピアホテル  日本弱視斜視学会, 日本小児眼科学会
  • 小児の眼内レンズ挿入眼の両眼視機能に対する累進屈折力眼鏡の効果
    田中 美夏, 松本 富美子, 日下 俊次.
    第71回日本弱視斜視学会総会第40回日本小児眼科学会合同学会  2015/07  神戸市, 神戸ポートピアホテル  日本弱視斜視学会, 日本小児眼科学会
  • 〔特別講演〕小児網膜硝子体疾患に対する外科的治療  [Not invited]
    日下 俊次
    第71回日本弱視斜視学会総会第40回日本小児眼科学会合同学会  2015/07  神戸  神戸市, 神戸ポートピアホテル
  • 【Invited Speaker as a Symposisit.】Intraoperative OCT in complex vitreoretinal surgery  [Not invited]
    Kusaka S.
    European Society of Ophthalmology  2015/06  Vienna, Austria
  • 〔特別講演〕小児難治性網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第5回仙台網膜道場  2015/05  仙台
  • 〔ランチョンセミナー〕難治性網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第9回四国PLUS ONE Eyeランドセミナー  2015/05  高松市, JRホテルクレメント高松
  • 〔特別講演〕難治性網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第17回「JON研究会」講演会  2015/05  東京
  • コーツ病に対する bevacizumab併用治療の効果  [Not invited]
    立花 都子, 日下 俊次, 初川 嘉一, 今泉 綾子, 兒玉 達夫, 下村 嘉一.
    第119回日本眼科学会総会  2015/04  札幌市, ロイトン札幌
  • 〔ランチョンセミナー〕小眼球対応 25G Shortウルトラビットプローブの使用経験  [Not invited]
    日下 俊次
    第119回日本眼科学会総会  2015/04  札幌市, ロイトン札幌
  • Use of IO-OCT in various vitro retinal Surgery  [Not invited]
    Kusaka S.
    Intra-Operative OCT Science Day  2015/02  Austria,Vienna
  • Vitrectomy for FEVR  [Not invited]
    Kusaka S.
    The International Meeting of the Egyptian Vitreoretinal Society EGVRS  2015/02  Cairo, Egypt
  • Short term postoperative Perfluoro-n-Octane in Pediatric Complex RD  [Not invited]
    Kusaka S.
    The International Meeting of the Egyptian Vitreoretinal Society EGVRS  2015/02  Cairo, Egypt
  • Intraoperative OCT findings in vitrectomy for various vitreoretinal disorders  [Not invited]
    Kusaka S.
    The International Meeting of the Egyptian Vitreoretinal Society EGVRS  2015/02  Cairo, Egypt
  • Venturi & peristaltic pumps fluidics and implications in different steps of vitreous surgery  [Not invited]
    Kusaka S.
    The International Meeting of the Egyptian Vitreoretinal Society EGVRS  2015/02  Cairo, Egypt
  • 〔特別講演〕硝子体手術 -最近の話題-  [Not invited]
    日下 俊次
    第75回 宮崎大学眼科研究会  2015/01  宮崎
  • 〔特別講演〕難治性網膜硝子体疾患に対する硝子体手術  [Not invited]
    日下俊次
    第三回 Osaka Ophthalmologist Meeting  2015/01  大阪
  • Surgery for Coats disease and PVR.
    Kusaka S.
    American Association for Pediatric Ophthalmology and Strabismus.  2014/11  京都市, 国立京都国際会館
  • Retinal surgery for ROP and FEVR  [Not invited]
    Kusaka S.
    American Association for Pediatric Ophthalmology and Strabismus.  2014/11  京都市, 国立京都国際会館
  • 硝子体手術後の未熟児網膜症例の5歳時視機能  [Not invited]
    立花 都子, 日下 俊次, 阿部 考助, 國吉 一樹, 杉岡 孝二, 松本 富美子, 下村 嘉一
    第53回日本網膜硝子体学会総会・第31回日本眼循環学会  2014/11  大阪市, 大阪国際会議場
  • 広角眼底観察システム用曇り防止装置の臨床応用  [Not invited]
    日下 俊次, 辻岡 大志, 立花 都子, 小池 英子, 檜垣 史郎, 下村 嘉一.
    第53回日本網膜硝子体学会総会・第31回日本眼循環学会  2014/11  大阪市, 大阪国際会議場
  • 網膜硝子体手術~合併症の予防と対策  [Not invited]
    日下 俊次
    第53回日本網膜硝子体学会総会・第31回日本眼循環学会  2014/11  大阪市, 大阪国際会議場
  • 重症コーツ病に対する治療  [Not invited]
    日下 俊次
    第237回O.C.C.  2014/11  大阪
  • 両眼同日白内障手術の検討  [Not invited]
    藤井 明子, 日下 俊次, 青松 圭一, 立花 都子, 小池 英子, 檜垣 史郎, 下村 嘉一.
    第68回日本臨床眼科学会  2014/11  神戸市, 神戸ポートピアホテル・神戸国際会議場
  • 眼科診療再考‐眼科治療進歩の功罪考UPDATE‐  [Not invited]
    日下 俊次
    第68回日本臨床眼科学会  2014/11  神戸市, 神戸ポートピアホテル・神戸国際会議場
  • 網膜剥離ファイトクラブ-症例をシェアして自分のものにする-  [Not invited]
    喜多 美穂里, 大島 佑介, 門之園 一明, 木村 英也, 日下 俊次, 栗山 晶治, 竹内 忍.
    第68回日本臨床眼科学会  2014/11  神戸市, 神戸ポートピアホテル・神戸国際会議場
  • 先読み白内障手術‐他疾患治療を見据えて‐  [Not invited]
    日下 俊次
    第68回日本臨床眼科学会  2014/11  神戸市, 神戸ポートピアホテル・神戸国際会議場
  • 術中OCTで確信の持てる状況判断  [Not invited]
    日下 俊次
    第68回日本臨床眼科学会  2014/11  神戸市, 神戸ポートピアホテル・神戸国際会議場
  • 重症例に対する抗VEGF併用治療の適応と限界  [Not invited]
    日下 俊次
    第68回日本臨床眼科学会  2014/11  神戸市, 神戸ポートピアホテル・神戸国際会議場
  • 網膜硝子体手術における術中OCTの有用性  [Not invited]
    日下 俊次
    第13回網膜ラウンジ  2014/11  東京都
  • 術中OCTの有用性について  [Not invited]
    日下 俊次
    第20回大阪眼科手術シンポジウム  2014/10  大阪
  • Vitrectomy,Perfluorocarbon,and External Subretinal Drainage for Eyes With Advanced Coats Disease With Total Retinal Detachment  [Not invited]
    Kusaka S.
    American Academy of Ophthalmology 2014  2014/10  Chicago,USA
  • Not New Technique:Coat’s Disease  [Not invited]
    Kusaka S
    Retina subspecialty day  2014/10  Chicago
  • 網膜静脈分子閉塞症の黄斑浮腫に対する硝子体手術の効果
    辻岡 大志, 立花 都子, 小池 英子, 檜垣 史郎, 日下 俊次.
    第3回泉北Ophthalmicセミナー  2014/10  大阪
  • 小児網膜硝子体疾患の外科的治療  [Not invited]
    日下 俊次
    瀬戸内眼科コロシアム2014  2014/09  広島市, シェラトングランドホテル広島
  • Real-time Intraoperative HD-OCT Findings during Vitrectomy for Retinal Detachment  [Not invited]
    Kusaka S, Tachibana K, Shimomura Y.
    14th Euretina Congress  2014/09  London
  • The use of intraoperative OCT for evaluation of IOL tilting  [Not invited]
    Kusaka S.
    RESCAN 700-Expert User Breakfast Meeting-Agenda  2014/09  London
  • Real-time intraoperative OCT findings during vitrectomy for various vitreoretinal disorders  [Not invited]
    Kusaka S.
    ZEISS Intra-Operative OCT Innovation Evening  2014/09  London,UK
  • 網膜剥離術中のOCT所見  [Not invited]
    日下俊次
    Japan Macula Club 第16回学術講演会  2014/08  名古屋市
  • 術中OCTの使用経験  [Not invited]
    日下俊次
    第3回 なんかい眼科フォーラム  2014/07  堺
  • 小児網膜、眼内レンズ強膜内固定  [Not invited]
    日下 俊次
    第13回硝子体手術ビデオセミナー  2014/06  東京
  • Systemic risks of anti-VEGF treatment of ROP  [Not invited]
    Kusaka S.
    The First International Pediatric Vitreoretinal Diseases Summit Forum  2014/06  Nanchang,China
  • Surgical management of ROP  [Not invited]
    Kusaka S.
    The First International Pediatric Vitreoretinal Diseases Summit Forum  2014/06  Nanchang,China
  • Comparison of outcomes of vitrectomy for stage 4A ROP w/ or w/o preoperative bevacizumab  [Not invited]
    Kusaka S
    The First International Pediatric Vitreoretinal Diseases Summit Forum  2014/06  Nanchang,China
  • Surgical treatment of severe Coats disease  [Not invited]
    Kusaka S.
    The First International Pediatric Vitreoretinal Diseases Summit Forum  2014/06  Nanchang,China
  • Short-term postoperative perfluoronoctane tamponade in pediatric complex retinal detachment  [Not invited]
    Kusaka S.
    The First International Pediatric Vitreoretinal Diseases Summit Forum  2014/06  Nanchang,China
  • 〔特別講演〕小児網膜硝子体疾患の診断と外科的治療  [Not invited]
    日下 俊次
    第7回紀の国眼疾患研究会  2014/05  和歌山県西牟婁郡白浜町
  • 〔特別講演〕小児網膜硝子体疾患の診断と外科的治療  [Not invited]
    日下 俊次
    第241回鹿児島眼科集談会  2014/05  鹿児島  鹿児島県眼科医会
  • 〔Invited Symposium〕Comparison of Surgical Results Between intrascleral IOL Fixation and IOL Suturing in Eyes without Capsular Support.
    Kusaka S.
    World Ophthalmology Congress of the International Council of Opthalmology  2014/04  Tokyo
  • 〔Invited Symposium〕Advance in the Management of ROP.
    Kusaka S.
    World Ophthalmology Congress of the International Council of Opthalmology.  2014/04  Tokyo
  • Understanding Differences in New-Generation MIVS Machines: EVA (DORC)  [Not invited]
    Kusaka S.
    World Ophthalmology Congress of the International Council of Opthalmology 2014  2014/04  Tokyo
  • Comparison of Surgical Results Between Intrascleral IOL Fixation and IOL Suturing in Eyes without Capsular Support  [Not invited]
    Kusaka S.
    World Ophthalmology Congress of the International Council of Opthalmology 2014  2014/04  Tokyo,International Forum and the Imperial Hotel Tokyo  日本眼科学会、日本学術会議
  • Advance in the Management of ROP  [Not invited]
    Kusaka S.
    World Ophthalmology Congress of the International Council of Opthalmology 2014  2014/04  Tokyo,International Forum and the Imperial Hotel Tokyo  日本眼科学会、日本学術会議
  • Case of Pupillary Block Glaucoma by Migration of Gas into Anterior Chamber after Lens-Sparing Vitrectomy (LSV) in an Infant  [Not invited]
    Fujii A, Kusaka S, Terai T, Shimomura Y.
    World Ophthalmology Congress of the International Council of Opthalmology 2014  2014/04  Tokyo
  • First experience with intra-operative OCT  [Not invited]
    Kusaka S.
    ZEISS Innovation Evening  2014/04  Tokyo
  • Short-term Postoperative Perfluoro-n-Octane Tamponade in Pediatric Complex RD  [Not invited]
    Kusaka S.
    Frankfurt Retina Meeting 2014  2014/03  Mainz, Germany  Klinikum Frankfurt Höchst Klinik für Augenheilkunde Ärztlicher Leiter: Prof. Dr. med. Claus Eckardt
  • Systemic Risks of anti VEGF treatment of ROP  [Not invited]
    Kusaka S
    Bali International Ophthalmology Retreat 2014  2014/02  Bali, Indonesia
  • Surgical management of ROP  [Not invited]
    Kusaka S.
    Bali International Ophthalmology Retreat 2014  2014/02  Bali, Indonesia
  • 未熟児網膜症に対するベバシズマブ単独治療の成績
    國吉 一樹, 杉岡 孝二, 櫻本 宏之, 下村 嘉一, 日下 俊次.
    第115回南大阪眼科勉強会  2014/02  大阪狭山市  近畿大学医学部眼科学教室
  • First experience with continuous OCT  [Not invited]
    Kusaka S.
    1st Intraoperative OCT Science Day  2014/02  Vienna, Austria
  • 〔特別講演〕日下俊次:小児網膜硝子体疾患治療の進歩  [Not invited]
    日下 俊次
    第31回近畿大学医学部眼科学教室同窓会  2014/02  堺
  • Combined treatment for Coats’ disease: Intravitreal bevacizumab injection (IVB) before retinal coagulation was effective in two cases  [Not invited]
    Kodama A, Sugioka K, Kusaka S, Kuniyoshi K, Matsumoto C, Shimomura Y.
    The8thAPVRS and The 52nd Annual Meeting of Japanese Retina and Vitreous Society  2013/12  名古屋  The8thAPVRS and The 52nd Annual Meeting of Japanese Retina and Vitreous Society
     
    ベバシズマブ硝子体注射併用網膜光凝固術が有効であった小児Coats病の2例報告。 症例1は15歳男児、Coats病stage3A。病巣部へのレーザー治療により一旦浮腫の軽減を認めたが5ヵ月後に再発し、その後レーザー単独治療に抵抗したため、ベバシズマブ硝子体注射後にレーザー網膜光凝固術を追加したところ、滲出性変化の減少および異常血管瘤の瘢痕化を認めた。症例2は11歳男児、レーザー単独治療に抵抗したため、ベバシズマブ硝子体注射後にレーザー治療を施行したところ滲出性変化の改善を認めた。滲出性変化の強いCoats病症例に対し、ベバシズマブとレーザー網膜光凝固術との併用治療は有効であると考えられた。
  • 【Symposium】Vitrectomy and Bevacizumab for Severe Retinopathy of Prematurity  [Not invited]
    Kusaka S.
    The8thAPVRS and The 52nd Annual Meeting of Japanese Retina and Vitreous Society  2013/12  名古屋  The8thAPVRS and The 52nd Annual Meeting of Japanese Retina and Vitreous Society
  • Case of Pupillary Block Glaucoma by Migration of Gas into Anterior Chamber After Lens-Sparing Vitrectomy(LSV) in an Infant.
    Fujii A, Kusaka S, Shimomura Y.
    The8thAPVRS and The 52nd Annual Meeting of Japanese Retina and Vitreous Society  2013/12  名古屋市  The8thAPVRS and The 52nd Annual Meeting of Japanese Retina and Vitreous Society
  • 〔特別講演〕小児網膜疾患に対する外科的治療
    日下 俊次
    第34回産業医大眼科研究会  2013/11  北九州市
  • An Adult Case of Optic Neuropathy Associated with Erythema Infectiosum  [Not invited]
    青松 圭一, 藤井 明子, 小池 英子, 立花 都子, 檜垣 史郎, 日下 俊次, 中尾 雄三, 遊佐留実.
    第51回日本神経眼科学会総会  2013/11  秋田市, 秋田拠点センターALVE(アルヴェ)  第51回日本神経眼科学会総会
  • Mittendorf spotを伴う高次収差の大きい不同視弱視の2症例
    福光 実里, 松本 富美子, 立花 都子, 小池 英子, 七部 史, 阿部 考助, 日下 俊次, 大沼 一彦.
    第54回日本視能矯正学会  2013/11  福岡市  公益社団法人日本視能訓練士協会
  • 【Keynote Lecture】Surgical Treatment of Complex Retinal Detachment  [Not invited]
    Kusaka S.
    The 2nd Annual Meeting of Taiwan Retina Society  2013/11  Taipei  Taiwan Retina Society
  • 【特別講演】小児における網膜硝子体手術  [Not invited]
    日下 俊次
    第43回RETINAの会  2013/11  横浜  第43回RETINAの会
  • 【特別講演】小児網膜疾患に対する外科的治療  [Not invited]
    日下 俊次
    第34回産業医大眼科研究会  2013/11  北九州  第34回産業医大眼科研究会
  • 伝染性紅斑(りんご病)に合併した視神経症の成人例
    青松 圭一, 藤井 明子, 小池 英子, 立花 都子, 檜垣 史郎, 日下 俊次, 中尾 雄三, 遊佐 留実.
    第6回奈良県眼科万葉フォーラム  2013/10  橿原市
  • 両眼同日白内障手術VS両眼連日白内障手術
    藤井 明子, 日下 俊次, 青松 圭一, 小池 英子, 立花 都子, 檜垣 史郎, 下村 嘉一.
    第2回泉北Ophthalmicセミナー  2013/10  大阪
  • 【特別講演】小児網膜手術 tips and pearls  [Not invited]
    日下 俊次
    第7回琵琶湖眼底疾患研究会  2013/10  大津  第7回琵琶湖眼底疾患研究会
  • An Adult Case of Optic Neuropathy Associated with Erythema Infectiosum  [Not invited]
    青松 圭一; 藤井 明子; 小池 英子; 立花 都子; 檜垣 史郎; 日下 俊次; 中尾 雄三; 遊佐留実
    第6回奈良県眼科万葉フォーラム  2013/10  橿原市  第6回奈良県眼科万葉フォーラム
  • オカルト黄斑変性のtwo-color perimetry  [Not invited]
    國吉 一樹, 角田 和繁, 赤堀 正和, 松本 長太, 日下 俊次,下村 嘉一.
    第15回Japan Macula Club  2013/08  蒲郡市  第15回Japan Macula Club
  • Subretinal drainage and vitrectomy are helpful in diagnosing and treating eye with advanced Coats’s disease  [Not invited]
    Imaizumi A, Kusaka S, Noguchi H
    Singapore National Eye Centre (SNEC) and AAPOS Joint Meeting  2013/07  Suntec City,Singapore  Singapore National Eye Centre (SNEC) and AAPOS Joint Meeting
  • Subretinal drainage and Vitrectomy are helpful in diagnosing and treating eye with advanced Coats' disease.
    Imaizumi A, Noguchi H, Kusaka S.
    Singapore National Eye Centre(SNEC) and AAPOS Joint Meeting  2013/07  Suntec City,Suntec Singapore International Convention and Exhibition Centre
  • 未熟児網膜症に対するベバシズマブ単独治療の成績  [Not invited]
    國吉 一樹, 杉岡 孝二, 櫻本 宏之, 辻岡 大志, 日下 俊次, 和田 紀久, 下村 嘉一.
    第69回日本弱視斜視学会総会・第38回日本小児眼科学会総会  2013/07  広島市  日本弱視斜視学会・日本小児眼科学会
  • 前房内に迷入した空気により瞳孔ブロックを来した小児の1例.
    藤井 明子, 日下 俊次, 河本 庄平, 青松 圭一, 小池 英子, 立花 都子, 檜垣 史郎, 下村 嘉一.
    第69回日本弱視斜視学会総会・第38回日本小児眼科学会総会  2013/07  広島  日本弱視斜視学会・日本小児眼科学会
  • 【特別講演】小児網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第69回Tokyo Ophthalmology Club  2013/06  東京  第69回Tokyo Ophthalmology Club
  • 【特別講演】小児網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第58回山陰眼科集談会  2013/06  出雲  第58回山陰眼科集談会
  • 【特別講演】小児網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第96回阪大眼科同窓会学術講演会  2013/06  大阪  第96回阪大眼科同窓会学術講演会
  • 〔特別講演〕小児網膜硝子体疾患の治療
    日下 俊次
    第96回阪大眼科同窓会学術講演会  2013/06  大阪大学医学部
  • TGF-β2 enhances urokinase type plasminogen activator (uPA), uPA receptor (uPAR) expression and binding activity of uPA to reinal pigment epithelial (RPE) cells and promotes RPE cell invasion into collagen gels by mediating uPA expression.  [Not invited]
    Sugioka K, Kodama A, Iwata M, Yoshida K, Okada k, Kusaka S, Matsumoto C, Shimomura Y.
    The Association for Reserch in vision and Ophthalmology 2013.  2013/05  Seattle  The Association for Reserch
     
    Transforming growth factor-beta (TGF-β)は、epithelial-mesenchymal transition (EMT)の主要関連分子のひとつであり、TGFβはEMTを促進し、細胞の移動、浸潤に関与している。今回我々は uPAのヒト培養網膜色素上皮細胞(ARPE19)のTGFβを介したEMTおよびtype1コラーゲンゲル内遊走に与える影響について検討した。ゲル内にARPE19を包埋し、uPAがTGFbeta2による細胞形態変化に与える影響および、ゲル内細胞遊走評価モデルにより、TGFb処理ARPE19のゲル内遊走抑制効果について検討した。TGFb刺激によるuPA, uPA receptor (uPAR)の発現をfibrin enzymography, western blot法およびreal time PCR法を用いて検討した。ARPE19とuPAの結合反応を生体分子間相互作用解析装置でそれぞれ検討した。ゲル内の細胞はTGFb刺激により線維芽細胞様の形態を示し,その形態変化はuPA阻害剤により抑制された。TGFb(10ng/ml)刺激によりuPAの産生は増加した。ゲル内に遊走する細胞数はuPA阻害剤により有意に抑制された(p<0.01)。uPA, uPARは、TGFbの刺激により依存的に発現上
  • Comparison of surgical results between intrascleral posterior chamber intraocular lens (PC-IOL) fixation and transscleral suturing of PC-IOL in eyes without capsular support  [Not invited]
    Kusaka S, Komoto S, Fujii A, Aomatsu K, Koike E, Tachibana K, Higaki S, Shimomura Y.
    The Association for Reserch in vision and Ophthalmology 2013.  2013/05  Seatle  2013 Association for Research in Vision and Ophthalmology
  • 【特別講演】小児網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    豊中市眼科医会学術研究会  2013/04  豊中市  豊中市眼科医会学術研究会
  • Efficacy of short-term postoperative PFO tamponade in pediatric complex retinal detachment  [Not invited]
    Kusaka S.
    The Vail Vitrectomy 2013 Meeting  2013/03  Vail  The Vail Vitrectomy 2013 Meeting
  • Vitrectomy for vitreoretinal complications in regressed ROP  [Not invited]
    日下 俊次
    Present and Future Challenges in Severe Retinal Diseases  2013/02  Verona  Present and Future Challenges in Severe Retinal Diseases
  • 【特別講演】小児網膜硝子体疾患の治療  [Not invited]
    日下 俊次
    第25回山形眼科先進医療研究会  2013/02  山形  第25回山形眼科先進医療研究会
  • 【シンポジウム】小児の網膜硝子体手術-小児の眼外傷・被虐待児-  [Not invited]
    日下 俊次
    第36回日本眼科手術学会総会  2013/01  福岡市, 福岡国際会議場/福岡サンパレス/マリンメッセ福岡  第36回日本眼科手術学会総会
  • 【教育セミナー】未熟児網膜症の診断と治療-未熟児網膜症に対する硝子体手術-  [Not invited]
    日下 俊次
    第36回日本眼科手術学会総会  2013/01  福岡市, 福岡国際会議場/福岡サンパレス/マリンメッセ福岡  第36回日本眼科手術学会総会
  • Laser and Avastin for ROP: indications and risks.
    Kusaka S.
    The 8th International Symposium of Ophthalmolog  2012/12  Hong Kong
  • 家族性惨出性硝子体網膜症の遺伝的要因:NOrrin- β -cateninシグナル系遺伝子の変異
    田平 知子, 吉永 亜紀, 日下 俊次, 林 孝彰, 内尾 英一, 田原 昭彦, 林 健志, 近藤 寛之.
    第35回日本分子生物学会年会  2012/12  福岡市, 福岡国際会議場
  • 水晶体嚢を有しない眼に対する眼内レンズ強膜内固定法の短期成績
    河本 庄平, 日下 俊次, 藤井 明子, 青松 圭一, 小池 英子, 立花 都子, 檜垣 史郎, 下村 嘉一.
    第51回日本網膜硝子体学会総会  2012/12  甲府市, 甲府富士屋ホテル
  • Visual Outcomes of Eyes after Lens-Sparing Vitrectomy for Stage 4A Retinopathy of Prematurity
    Iwahashi C, Kusaka S, Morimoto T, Fujikado T, Abe K, Shimomura Y, Nishida K.
    第51回日本網膜硝子体学会総会  2012/11  甲府市, 甲府富士屋ホテル
  • Genetic Variants of FZD4 Gene in Eyes with Advanced Retinopathy of Prematurity
    Kondo H, Kusaka S, Yoshinaga A, Uchio E, Tawara A, Tahira T.
    第51回日本網膜硝子体学会総会  2012/11  甲府市, 甲府富士屋ホテル
  • ウロキナーゼ型プラスミノーゲン活性化因子によるRPEのコラーゲンゲル内遊走作用
    杉岡 孝二, 児玉 彩, 岩田 美穂子, 岡田 清孝, 日下 俊次, 松本 長太, 下村 嘉一.
    第51回日本網膜硝子体学会総会  2012/11  甲府市, 甲府富士屋ホテル
  • 網膜硝子体疾患治療のトレンド  [Not invited]
    日下 俊次
    All in One  2012/11  富山市  All in One
  • 硝子体手術 最近のトレンド  [Not invited]
    日下 俊次
    第13回大阪赤十字眼科フォーラム  2012/11  大阪  第13回大阪赤十字眼科フォーラム
  • Comparison of Outcomes ofVitrectomy for Stage 4A ROP With or Without Preoperative Bevacizumab
    Kusaka S, Kuniyoshi K, Shima C, Abe K, Shimomura Y.
    2012 Joint Meeting of the American Academy of Ophthalmology and the Asia-Pacific Academy of Ophthalmology  2012/11  Chicago, USA
  • 網膜剥離ファイトクラブ一手術合併症への挑戦一
    喜多 美穂里, 木村 英也, 日下 俊次, 栗山 晶治, 斉藤 喜博, 塚原 康友, 安原 徹, 池田 恒彦.
    第66回日本臨床眼科学会  2012/10  京都市, 国立京都国際会館
  • レチナナイトメア-合併症の悪夢3-
    恵美 和幸, 門之園 一明, 北岡 隆, 木村 英也, 日下 俊次, 國方 彦志.
    第66回日本臨床眼科学会  2012/10  京都市, 国立京都国際会館
  • 未熟児網膜症(ROP)に対するベバシズマブ(アバスチンR)投与  [Not invited]
    日下 俊次
    第66回日本臨床眼科学会  2012/10  京都市, 国立京都国際会館  第66回日本臨床眼科学会
  • 小児眼科  [Not invited]
    日下 俊次
    第7回東北6大学眼科Step Upセミナー  2012/09  仙台市  第7回東北6大学眼科Step Upセミナー
  • 小児網膜硝子体疾患治療の最前線  [Not invited]
    日下 俊次
    第18回とやま眼科学術講演会  2012/07  富山市  第18回とやま眼科学術講演会
  • 単純血漿交換が有効であった抗アクアポリン4抗体陽性視神経炎の1例  [Not invited]
    青松 圭一; 藤井 明子; 河本 庄平; 小池 英子; 立花 都子; 檜垣 史郎; 日下 俊次; 中尾 雄三; 阪本 光; 上野 周一; 中村 雄作
    第1回なんかい眼科フォーラム  2012/07  大阪  第1回なんかい眼科フォーラム
  • 小児網膜  [Not invited]
    日下 俊次
    第11回 硝子体手術ビデオセミナー  2012/07  東京都, 品川カンファレンスセンター  第11回 硝子体手術ビデオセミナー
  • Peters奇形を伴った未熟児網膜症に対する治療
    南 毅, 日下 俊次, 園吉 一樹, 坂本 万寿夫, 櫻本 宏之, 福田 昌彦, 松本 長太, 下村 嘉一, 伊藤 久太郎.
    第68回日本弱視斜視学会総会・第37回日本小児眼科学会総会  2012/06  名古屋市, 名古屋国際会議場
  • RetCam IIIの紹介と実際  [Not invited]
    日下 俊次
    第68回日本弱視斜視学会総会・第37回日本小児眼科学会総会  2012/06  名古屋市  第68回 日本弱視斜視学会総会・第37回日本小児眼科学会総会
  • Intraocular Pressure Elevation Is A Delayed-onset Complication After Successful Vitrectomy For Stages 4 And 5 Retinopathy Of Prematurity.
    Kusaka S, Iwahashi-Shima C, Miki A, Matsushita K, Hamasaki T, Otori Y, Kiuchi Y, Okada M.
    The Association for Research in Vision and Ophthalmology 2012  2012/05  Fort Lauderdale, USA
  • Efficacy of Short-term Postoperative Perfluoron-n-octane Tamponade for Pediatric Proliferative Vitreoretinopathy.
    Imaizumi A, Kusaka S, Hayasaka K, Noguchi H, Shimomura Y.
    The Association for Research in Vision and Ophthalmology 2012  2012/05  Fort Lauderdale, USA
  • Peters奇形を伴った未熟児網膜症に対する治療
    南 毅, 國吉 一樹, 日下 俊次, 坂本 万寿夫, 櫻本 宏之, 杉岡 孝二, 福田 昌彦, 松本 長太, 伊藤 久太郎, 下村 嘉一.
    第387回大阪眼科集談会  2012/04  大阪市  一般社団法人大阪府眼科医会
  • 577nmイエローパターンスキャンレーザーの使用経験  [Not invited]
    日下 俊次
    第116回日本眼科学会総会  2012/04  東京都, 東京国際フォーラム  第116回日本眼科学会総会
  • Peters奇形を伴った未熟児網膜症に対する治療
    南 毅, 日下 俊次, 國吉 一樹, 櫻本 宏之, 坂本 万寿夫, 杉岡 孝二, 福田 昌彦, 松本 長太, 下村 嘉一, 伊藤 久太郎.
    第108回南大阪眼科勉強会  2012/03  大阪狭山市
  • Laser and Avastin for ROP: indications and risks  [Not invited]
    日下 俊次
    Frankfurt Retina Meeting 2012  2012/03  Frankfurt, Germany  Frankfurt Retina Meeting 2012
  • 近畿大学堺病院の現状と未来  [Not invited]
    日下 俊次
    第12回近畿眼科先進医療研究会  2012/03  大阪市  第12回近畿眼科先進医療研究会
  • Vitrectomy: History & Cutting edge -Stellaris�� PC-  [Not invited]
    日下 俊次
    第35回 日本眼科手術学会総会  2012/01  名古屋市, 名古屋国際会議場  第35回日本眼科手術学会総会
  • 577nmイエローパターンスキャンレーザーの使用経験  [Not invited]
    日下 俊次
    第35回 日本眼科手術学会総会  2012/01  名古屋市, 名古屋国際会議場  第35回 日本眼科手術学会総会
  • 新生児 網膜血管異常に対するベパシズ、マブ?硝子体注射による病勢のコントローノレ
    藤田 陽子, 塚本 晶子, 田邉 美香, 石田 貴美子, 江内田 寛, 吉川 洋, 日下 俊次, 石橋 達朗.
    第35回日本眼科手術学会総会  2012/01  名古屋市, 国際会議場
  • 糖尿病黄斑浮腫に対する硝子体手術の成績  [Not invited]
    日下 俊次
    第35回 日本眼科手術学会総会  2012/01  名古屋市, 名古屋国際会議場  第35回 日本眼科手術学会総会
  • 猫引っ掻き病による視神経網膜炎の一例
    青松 圭一, 立花 都子, 檜垣 史郎, 日下 俊次, 中尾 雄三, 萱澤 朋泰, 河本 庄平.
    第19回飛蝗の会  2011/10  堺市
  • アイカップ法により得られた検体の細菌、真菌、ウイルスDNA
    河本 庄平, 檜垣 史郎, 板橋 幹城, 福田 昌彦, 萱澤 朋泰, 青松 圭一, 立花 都子, 日下 俊次, 中尾 雄三, 下村 嘉一.
    第384回大阪眼科集談会  2011/10  大阪市  一般社団法人大阪府眼科医会
  • 猫引っ掻き病によ る視神経網膜炎の一例
    青松 圭一, 立花 都子, 檜垣 史郎, 日下 俊次, 中尾 雄三, 萱澤 朋泰 河本 庄平.
    第106回南大阪眼科勉強会  2011/08  大阪狭山市
  • 伝染性紅斑(りんご病)に合併した視神経症の成人例
    青松 圭一, 櫻本 宏之, 河本 庄平, 小長谷 奈美, 有村 英子, 櫓垣 史郎, 日下 俊次, 中尾 雄三, 遊佐 留美.
    第382回大阪眼科集談会  2011/06  大阪市  一般社団法人大阪府眼科医会
  • 伝染性紅斑(りんご病)に合併した視神経症の成人例
    青松 圭一, 櫻本 宏之, 河本 庄平, 小長谷 奈美, 有村 英子, 檎垣 史郎, 日下 俊次, 中尾 雄三, 遊佐 留美.
    第105回南大阪勉強会  2011/05  大阪
  • Current Concept and Management of Severe Retinopathy of Prematurit
    Kusaka S.
    第51回中華民国眼科医学会学術演講  2010/12  Taipei
  • Stage 3未熟児1網膜症に対するbevacizumab硝子体内投与の短期成績
    日下 俊次, 荒堀 仁美, 和田 和子, 岩橋 千春 , 佐藤 達彦.
    第49回日本網膜硝子体学会総会・第16回日本糖尿病眼学会総会合同総会  2010/11  大阪市, 大阪国際会議場
  • 糖尿病網膜症
    日下 俊次.
    第2回糖尿病講演会  2010/11  柏原市
  • 〔インストラクションコース〕重症未熟児網膜症の管理一いかに光凝固し、いかに次の治療を考えるかー
    東 範行, 平岡 美依奈, 日下 俊次.
    第64回日本臨床眼科学会  2010/11  神戸市, 神戸国際展示場
  • TSPAN12遺伝子異常による家族性渉出性硝子体網膜症
    近藤 寛之, 日下 俊次, 吉永 亜紀, 内尾 英一, 田原 昭彦, 林 健志, 田平 知子.
    第64回日本臨床眼科学会  2010/11  神戸市, 神戸国際展示場
  • 小児白内障手術成功のポイント
    日下 俊次.
    第64回日本臨床眼科学会  2010/11  神戸市, 神戸国際展示場
  • 〔インストラクションコース〕網膜剥離ファイトクラブ一難治症例の克服ー
    喜多 美穂里, 栗山 晶治 , 日下 俊次, 塚原 康友, 木村 英也, 斉藤 喜博 池田 恒彦.
    第64回日本臨床眼科学会  2010/11  神戸市, 神戸国際展示場
  • [教育セミナー〕レットカムによるROPに対する抗VEGF治療の評価
    日下 俊次.
    第55回日本未熟児新生児学会・学術集会  2010/11  神戸市, 神戸国際会議場
  • Anatomical and Functional Outcomes of Vitrectomy for Stage 4A ROP
    Shima C, Kusaka S, Sato T.
    2010 American Academy of Ophthalmology Meeting  2010/10  Chicago, USA
  • Vitreous Levels of Angiopoietin-1 and -2 in Eyes With ROP
    Sato T, Shima C, Kusaka S.
    2010 American Academy of Ophthalmology Meeting  2010/10  Chicago, USA
  • stage 3 ROPに対する硝子体内アパスチン投与.
    日下 俊次.
    第12回JapanMacula Club 総会  2010/08  蒲郡市
  • Stage 4A未熟児網膜症に対する硝子体手術後の視機能
    島 千春, 日下 俊次, 下保 裕史, 森本 荘, 不二円 尚.
    第66回日本弱視斜視学会総会・第35回日本小児眼科学会合同総会  2010/07  東京都, 品川プリンスホテルアネックスタワー  金沢大学付属病院眼科
  • Bevacizumab硝子体内投与のみで寛解したAP-ROPの一例
    遠藤 高生, 日下 俊次, 荒堀 仁美, 和田 和子, 園吉 一樹, 黒田 聡, 森本 荘, 不二門 尚.
    第66回日本弱視斜視学会総会・第35回日本小児眼科学会合同総会  2010/07  東京都, 品川プリンスホテルアネックスタワー  金沢大学付属病院眼科
  • 未熟児網膜症における硝子体手術
    藤井清美、下條裕史、大下貴志、日下俊次、喜田照代、岩崎佳子、張野正誉、初川嘉一.
    第58回日本臨床眼科学会  千代田区, 東京国際フォーラム  東京医科大学
  • 児の眼底疾患  [Not invited]
    日下俊次
    第93回岡山大学眼科研究会  岡山市

Affiliated academic society

  • JAPANESE ASSOCIATION OF PEDIATRIC OPHTHALMOLOGY   THE VITREORETINA SOCIETY OF JAPAN   日本眼科学会   The Association for Research in Vision and Ophthalmology   欧州網膜硝子体学会(EVRS)   欧州網膜学会(Euretina)   小児網膜外科学会(APRS)   米国眼科学会(AAO)   米国視覚眼科学会(ARVO)   

Research Themes

  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2017/04 -2020/03 
    Author : Kusaka S, Kuniyoshi K, Sugioka K.
     
    Anti-vascular endothelial growth factor (VEGF) therapy was performed for infants with severe retinopathy of prematurity (ROP). Reactivation was observed in 20.9% of 43 eyes of 22 infants after ranibizumab injection and 13.5% of 37 eyes of 21 infants after bevacizumab injection(P=0.556). Multivariate logistic regression analyses revealed that anti-VEGF therapy at 35 weeks or younger post-conceptional age (OR, 7.524; 95% CI, 1.494–37.89; p = 0.014) and aggressive posterior ROP (OR, 5.532; 95% CI, 1.049–29.17; p = 0.044) were the significant risk factors for reactivation.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2014/04 -2017/03 
    Author : Kusaka S, Kuniyoshi K, Sugioka K.
     
    Intravitreal injection of ranibizumab (IVR) was performed in 27 eyes of 14 patients with severe retinopathy of prematurity (ROP). In each eyes, improvement of vascular dilatation and tortuosity, regression of tunica vasculosa lentis, and/or whitening of fibrovascular membranes was observed. Thus, IVR seemed to be effective in reducing disease activity in all eyes. However, reactivation was seen in 7 eyes at 7.3 weeks (mean) after IVR. Suppression of serum vascular endothelial growth factor was observed only at one day, but not 1, 2, and 4 weeks after IVR, compared with that of pre-IVR.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2011 -2013 
    Author : Kusaka S, Kuniyoshi K.
     
    Serum samples were collected from 11 infants with ROP who had received intravitreal bevacizumab injection before and 1 day, 1 week, and 2 weeks after the injection. The serum concentrations of bevacizumab and VEGF were measured by enzyme-linked immunosorbent assay. As a result, the serum concentration of bevacizumab before and 1 day, 1week, and 2 weeks after a total of 0.5 mg of intravitreal bevacizumab was 0, 195, 946L, and 1214 (ng/mL), respectively. The serum concentration of VEGF before and 1 day, 1 week, and 2 weeks after a totalof 0.5 mg intravitreal bevacizumab was 1628, 427, 246, and 269 (pg/mL), respectively. There was a significant negative correlation (r= 0.575, P=0.0125) between the serum concentration of bevacizumab and VEGF. These results indicate that bevacizumab can escape from the eye into the systemiccirculation and reduce the serum level of VEGF in infants with ROP.
  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2008 -2010 
    Author : Kusaka S, Oshima Y, Fujikado T, Saishin Y.
     
    Gene expression profiles of oxygen-induced retinopathy and control mice were investigated using real-time PCR. Upregulation of genes associated with inflammation were observed 2 days before the development of neovascularization (NV), and continued until a few days after disappearance of NV. On the other hand, upregulation of genes associated with NV, such as vascular endothelial growth factor and angiopoietin-2, were observed from one day before the development of NV until the disappearance of NV.
  • 網膜硝子体疾患の外科的治療
  • Surgical treatment of vitreoretinal disorders

Others

  • 認定資格 
    眼科PDT(光線力学的療法)認定医
  • 認定資格 
    日本眼科学会専門医