KINDAI UNIVERSITY


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Hiroaki Kume

Profile

FacultyDepartment of Medicine / Graduate School of Medical Sciences
PositionAssociate Professor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/626-kume-hiroaki.html
URL
Mail
Last Updated :2019/04/22

Education and Career

Education

  •  - 1990 , Nagoya University, Graduate School, Division of Medicine

Research Activities

Research Areas

  • Basic medicine, General physiology
  • Clinical internal medicine, General internal medicine (including psychosomatic medicine)
  • Clinical internal medicine, Respiratory organ internal medicine

Books etc

  • Mechanisms underlying beta-adrenoceptor-mediated relaxation in guinea-pig tracheal smooth muscle., beta-Adrenoceptor agonists and airways. London, Roy. Soc. Press. etited by R. S. Small & M. Johnson.,   1994
  • Electrophysiology of potassium channels in airway smooth muscle, Airway Smooth Muscle : Development and Regulation of Contractility. Birkhauser Verlag edited by D. Reaburn and M. A. Giembycz,   1994

Works

  • Involvement of Ca2+ mobilization in tachyphylaxis to beta-adrenergic receptors in airway smooth muscle

Misc

  • RhoA/Rho-kinase as a therapeutic target in asthma, Curr Med Chem, 15, 27, 2876, 2885,   2008 , 10.2174/092986708786242831
  • Role of Ca2+ mobilization in desensitization of beta-adrenoceptors by platelet-derived growth factor in airway smooth muscle, Eur J Pharmacol, 591, 1-3, 259, 265,   2008 , 10.1016/j.ejphar.2008.06.072
  • Mast cell tryptase causes homologous desensitization of beta-adrenoceptors by Ca2+ sensitization in tracheal smooth muscle, Clin Exp Allergy, 38, 1, 135, 144,   2008 , 10.1111/j.1365-2222.2007.02879.x
  • A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells., Am J Respir Cell Mol Biol, 38, 4, 407, 413,   2008 , 10.1165/rcmb.2007-0259OC
  • Role of P2X receprors and Ca2+ sensitization in extracellular adonosine triphosphate-induced hyperresponsiveness in airway smooth muscle, Clin Exp Allergy, 37, 6, 893, 900,   2007 , 10.1111/j.1365-2222.2007.02719.x
  • Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges, Clin Exp Allergy, 37, 4, 599, 607,   2007 , 10.1111/j.1365-2222.2007.02693.x
  • Sphingosine 1-phosphate causes airway hyper-reactivity by Rho mediated myosin phosphatase inactivation, J Pharmacol Exp Ther, 320, 2, 766, 773,   2007 , 10.1124/jpet.106.110718
  • Direct effects of hydrogen peroxide on airway smooth muscle tone: roles of Ca2+ influx and Rho-kinase, Eur J Pharmacol, 556, 1-3, 151, 156,   2007 , 10.1016/j.ejphar.2006.11.007
  • Essential role of GATA trabscriptional factors in the activation of mast cells, J Immunol, 178, 1, 360, 368,   2007
  • Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle, Am J Respir Cell Mol Biol, 35, 6, 722, 729,   2006 , 10.1165/rcmb.2006-0034OC
  • Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction od airway smooth muscle, Eur J Pharmacol, 552, 1-3, 135, 142,   2006 , 10.1016/j.ejphar.2006.08.067
  • Comparison of the effects of tulobuterol patch and salmeterol in moderate to severe asthma, Clin Exp Pharmacol Physiol, 33, 11, 1016, 1021,   2006 , 10.1111/j.1440-1681.2006.04480.x
  • Paradoxical effects of hydrogen peroxide on human airway anion secretion, J Pharmacol Exp Ther, 318, 1, 296, 303,   2006 , 10.1124/jpet.106.102541
  • Viscoelastic and dynamic nonlinear properties of airway smooth muscle tissue: roles of mechanical force and the cytoskeleton, Am J Physiol Lung Cell Mol Physiol, 290, 6, L1227-1237,   2006 , 10.1152/ajplung.00299.2005
  • Phase I/II trial of docetaxel and carboplatin as a first-line therapy in patients with stage IV non-small-cell lung cancer, Lung, 184, 3, 133, 139,   2006 , 10.1007/s00408-005-2572-1
  • Interstitial lung disease associated with gefitinib, Respir Med, 100, 4, 698, 704,   2006 , 10.1016/j.rmed.2005.07.015
  • Involvement of reduced sensitivity to Ca2+ in beta-adrenergic action on airway smooth muscle, Clin Exp Allergy, 36, 2, 183, 191,   2006 , 10.1111/j.1365-2222.2006.02412.x
  • Mutation of epidermal growth factor of non-small cell lung cancer were associated with sensitivity to gefitinib in recurrence after surgery, Lung Cancer, 50, 3, 385, 391,   2005 , 10.1016/j.lungcan.2005.06.008
  • Ion transport regulated by protease-activated receptor 2 in human airway Calu-3 epithelia., Br J Pharmacol, 146, 3, 397, 407,   2005 , 10.1038/sj.bjp.0706330
  • Clinical use of beta2-adrenergic receptor agonists based on their intrinsic efficacy, Allergology Int., 54, 1, 89, 97,   2005 , 10.2332/allergolint.54.89
  • Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy., Cancer Detect Prev, 29, 2, 175, 180,   2005 , 10.1016/j.cdp.2004.09.001
  • Regulation of airway anion secretion via CFTR in sphingomyelin pathway., Biochem Biophys Res Commun, 324, 2, 901, 908,   2004 , 10.1016/j.bbrc.2004.09.134
  • The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells, J Immunol, 173, 9, 5564, 5573,   2004
  • Role of lysophosphatidylcholine in eosinophil infiltration and resistance in airways., Clin Exp Pharmacol Physiol, 31, 3, 179, 184,   2004 , 10.1111/j.1440-1681.2004.03973.x
  • ATP release triggered by activation of Ca2+-activated K+ channel in human airway Calu-3 cells., Am J Respir Cell Mol Biol, 30, 3, 388, 395,   2004 , 10.1165/rcmb.2003-0184OC
  • Apical and basolateral ATP-induced anion secretion in polaried human airway epithelia., Am J Respir Cell Mol Biol, 30, 3, 411, 419,   2004 , 10.1165/rcmb.2003-0183OC
  • Effects of fluoranthene, a polycyclic aromatic hydrocarbon, on cAMP-dependent anion secretio0n in human airway epithelia., J Pharmacol Exp Ther, 308, 2, 651, 657,   2004 , 10.1124/jpet.103.059089
  • ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis., Eur J Pharmacol, 486, 3, 325, 333,   2004 , 10.1016/j.ejphar.2004.01.013
  • Involvement of Ca2+ mobilization in tachyphylaxis to beta-adrenergic receptors in trachealis., Am J Respir Cell Mol Biol, 29, 3, 359, 366,   2003 , 10.1165/rcmb.2002-0197OC
  • Inhibitory effects of interferon-gannma on the heterologous desensitization of beta-adrenoceptors by transforming growth factor-beta 1 in tracheal smooth muscle., Clin Exp Allergy, 33, 6, 808, 815,   2003 , 10.1046/j.1365-2222.2003.01681.x
  • Asthma health status: influence of disease severity categorized by peak expiratory flow, J Asthma, 40, 3, 281, 287,   2003 , 10.1081/JAS-120018327
  • Effects of direct and indirect activation of G protein of adenylyl cyclase on the subsequent response to beta-adrenergic receptor agonists in human trachealis, Arzneimittelforschung, 52, 11, 803, 812,   2002
  • Effects of sustained-release tulobuterol on asthma control and beta-adrenoceptor function., Clin Exp Phrmacol Physiol, 29, 12, 1076, 1083,   2002 , 10.1046/j.1440-1681.2002.03777.x
  • Regulation of capacitative and noncapacitative receptor-operated Ca2+ entry by Rho-kinase in tracheal smooth muscle, Am J Respir Cell Mol Biol, 26, 4, 491, 498,   2002
  • Bioelectric toxity caused by chlorpromazine in human lung epithelial cells, Toxicol Appl Pharmacol, 183, 3, 198, 206,   2002 , 10.1006/taap.2002.9486
  • Different effects of beta-adrenergic desensitization on inhibitory actions in guinea-pig trachealis, Clin Exp Pharmacol Physiol, 29, 8, 646, 654,   2002 , 10.1046/j.1440-1681.2002.03715.x
  • Bisphenol A inhibits Cl- secretion by inhibition of Basolateral K+ conduction in human airway epithelial cells, J Pharmacol Exp Ther, 320, 1, 80, 87,   2002 , 10.1124/jpet.302.1.80
  • Role of lysophosphatidylcholine in the desensitization of the beta-adrenergic receptors by Ca2+ sensitization in tracheal smooth muscle, Am J Respir Cell Mol Biol, 25, 3, 291, 298,   2001
  • Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells, Clin Exp Immunol, 126, 3, 384, 389,   2001 , 10.1046/j.1365-2249.2001.01646.x
  • Protection by tetracyclines against ion transport distruption caused by nystatin in human airway epithelial cells, Toxicol Appl Pharmacol, 177, 3, 232, 237,   2001 , 10.1006/taap.2001.9313
  • A seroepidemiological study of the risks of Q fever infection in Japanese veterinarians, Eur J Epidemiol, 17, 11, 1029, 1032,   2001 , 10.1023/A:1020018907452
  • Novel effects of minocycline on Ca2+-dependent Cl- secretion in human airway epithelial Calu-3 cells, Toxicol Appl Pharmacol, 176, 2, 101, 109,   2001 , 10.1006/taap.2001.9261
  • Adorenomedulin and proadrenomedulin N-terminal 20 peptide induce histamine release from rat peritoneal mast cell, Regul Pept, 101, 1-3, 163, 168,   2001 , 10.1016/S0167-0115(01)00283-X
  • [(Dihydroindeny)oxy]alkonic acid inhibts the cystic fibrosis transmembrane conductance regulator, Eur J Pharmacol, 426, 3, 175, 178,   2001 , 10.1016/S0014-2999(01)01106-2
  • Effect of prolonged low-dose methylprednisolone therapy in acute exacerbation of idiopathic pulmonary fibrosis, Respir Care, 46, 7, 698, 701,   2001
  • Possible involvement of Rho kinase in Ca2+ sensitization and mobilization by MCh in tracheal smooth muscle, Am J Physiol, 280, 6, L1218-1224,   2001
  • Inhibition of β-adrenergic desensitization by Kca channels in human trachealis, Am J Respir Crit Care Med, 159, 2, 452,   1999
  • Theophylline induces apoptosis of the IL-3 activated epsonophils of patients with bronchial asthma, Apoptosis, 4, 6, 461, 468,   1999 , 10.1023/A:1009656527168
  • Inhibitory effects of Gs on desensitization of β-adrenergic receptors in tracheal smooth muscle., Am J Physiol, 273, 3, L556-564,   1997
  • Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure., Clin Exp Allergy, 27, 6, 705, 713,   1997 , 10.1111/j.1365-2222.1997.tb01200.x
  • Role of G poteins and Kca channels in muscarinic and β-adrenergic regulation of airway smooth muscle., Am J Physiol, 268, 2, L221-229,   1995
  • β-Adrenergic agonists regulate Kca channels in airway smooth muscle by cAMP-dependent and-independent mechanisms., J Clin Invest, 93, 1, 371, 379,   1994
  • Role of calcium-activated potassium channels in the relaxation of tracheal smooth muscle, Clin Exp Pharmacol Physiol, 21, 5, 367, 375,   1994 , 10.1111/j.1440-1681.1994.tb02529.x
  • Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins., Proc Natl Acad Sci U S A, 89, 22, 11051, 11055,   1992 , 10.1073/pnas.89.22.11051
  • Muscarinic inhibition of single Kca channels in smooth muscle cells by a pertussis-sensitive G protein., Am J Physiol, 261, 6, 1204, 1209,   1991
  • Effects of intracellular pH on calcium-activated potassium channels in rabbit tracheal smooth muscle., J Physiol, 424, 445, 457,   1990
  • Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation., Nature, 341, 6238, 152, 154,   1989 , 10.1038/341152a0

Research Grants & Projects

  • Mechanisms of contraction and relaxation in airway smooth muscle
  • involvement of phospholipid in the pathophysiology of bronchial asthma
  • charateristic feature of beta-adrenergic receptor agonists based on intrinsic efficacy
  • Mechanisms of the effect of oxidative stress on airways
  • mechanisms of eosinophil infiltration to the airaways induce by antigen
  • eosinophlic airway inflammation, airway smooth muscle cells, cell proliferation, cell migration
  • Evaluation of eosinophilic in flammation in the peripheral airways in patients with asthma and COPD
  • Role of perticle sizes in inhibiting eosinophilic inflammation in the airways in the inhaled glucocorticosteroid therapy