NAGAOKA Takashi

Researcher Information

URL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901080425608250

ORCID ID

•  https://orcid.org/0000-0002-7460-5008

J-Global ID

• 200901080425608250

Research Interests

• メラノーマ   ハイパースペクトラルイメージング   表在性腫瘍   無侵襲計測   生体情報・計測   眼底   応用分光学   医療機器開発   内視鏡   検査・診断システム   医用・生体画像   

Research Areas

• Life sciences / Dermatology
• Life sciences / Medical systems
• Life sciences / Digestive surgery
• Life sciences / Biomaterials
• Life sciences / Biomedical engineering

Academic & Professional Experience

• 2023/04 - Today  Kindai UniversityFaculty of Biology-Oriented Science and Technology Department of Computational Systems BiologyAssociate Professor
• 2015/04 - 2023/03  Kindai UniversityFaculty of Biology-Oriented Science and Technology, Department of Computational Systems Biology講師
• 2009/04 - 2015/03  Waseda UniversityFaculty of Science and Engineering次席研究員
• 2006/04 - 2009/03  県立静岡がんセンター研究所任期付研究員
• 2003/04 - 2006/03  Waseda UniversitySchool of Science and Engineering助手

Education

• 2002/04 - 2005/03  Waseda University  Graduate School of Science and Engineering  生命理工学専攻博士後期課程
• 2000/04 - 2002/03  Waseda University  Graduate School of Science and Engineering  電子・情報通信学専攻修士課程
• 1996/04 - 2000/03  Waseda University  School of Science and Engineering  電子情報通信学科

Association Memberships

• 日本皮膚悪性腫瘍学会   THE SOCIETY OF INSTRUMENT AND CONTROL ENGINEERS   IEEE   電気学会   JAPANESE SOCIETY FOR MEDICAL AND BIOLOGICAL ENGINEERING   

Published Papers

• II-26 Unsupervised Feature Extraction for Various Computer-Aided Diagnosis Using Multiple Convolutional Autoencoders and 2.5-Dimensional Local Image Analysis

  Mitsutaka Nemoto; Kazuyuki Ushifusa; Yuichi Kimura; Takashi Nagaoka; Takahiro Yamada; Takeharu Yoshikawa

  Applied Sciences MDPI AG 13 (14) 8330 - 8330 2023/07 

  There are growing expectations for AI computer-aided diagnosis: computer-aided diagnosis (CAD) systems can be used to improve the accuracy of diagnostic imaging. However, it is not easy to collect large amounts of disease medical image data with lesion area annotations for the supervised learning of CAD systems. This study proposes an unsupervised local image feature extraction method running without such disease medical image datasets. Local image features are one of the key determinants of system performance. The proposed method requires only a normal image dataset that does not include lesions and can be collected easier than a disease dataset. The unsupervised features are extracted by applying multiple convolutional autoencoders to analyze various 2.5-dimensional images. The proposed method is evaluated by two kinds of problems: the detection of cerebral aneurysms in head MRA images and the detection of lung nodules in chest CT images. In both cases, the performance is high, showing an AUC of more than 0.96. These results show that the proposed method can automatically learn features that are useful for lesion recognition from lesion-free normal data, regardless of the type of image or lesion.
• II-25 Automatic detection of primary and metastatic lesions on cervicothoracic region and whole-body bone using a uniform machine-learnable approach for [18F]-FDG-PET/CT image analysis.

  Mitsutaka Nemoto; Atsuko Tanaka; Hayato Kaida; Yuichi Kimura; Takashi Nagaoka; Takahiro Yamada; Kohei Hanaoka; Kazuhiro Kitajima; Tatsuya Tsuchitani; Kazunari Ishii

  Physics in medicine and biology 67 (19) 2022/09 [Refereed]
   

  We propose a method to detect primary and metastatic lesions with Fluorine-18 fluorodeoxyglucose (FDG) accumulation in the lung field, neck, mediastinum, and bony regions on the FDG-PET/CT images. To search for systemic lesions, various anatomical structures must be considered. The proposed method is addressed by using an extraction process for anatomical regions and a uniform lesion detection approach. The uniform approach does not utilize processes that reflect any region-specific anatomical aspects but has a machine-learnable framework. Therefore, it can work as a lesion detection process for a specific anatomical region if it machine-learns the specific region data. In this study, three lesion detection processes for the whole-body bone region, lung field, or neck-mediastinum region are obtained. These detection processes include lesion candidate detection and false positive (FP) candidate elimination. The lesion candidate detection is based on a voxel anomaly detection with a one-class support vector machine. The FP candidate elimination is performed using an AdaBoost classifier ensemble. The image features used by the ensemble are selected sequentially during training and are optimal for candidate classification. Three-fold cross-validation was used to detect performance with the 54 diseased FDG-PET/CT images. The mean sensitivity for detecting primary and metastatic lesions at 3 FPs per case was 0.89 with a 0.10 standard deviation (SD) in the bone region, 0.80 with a 0.10 SD in the lung field, and 0.87 with a 0.10 SD in the neck region. The average areas under the ROC curve were 0.887 with a 0.125 SD for detecting bone metastases, 0.900 with a 0.063 SD for detecting pulmonary lesions, and 0.927 with a 0.035 SD for detecting the neck-mediastinum lesions. These detection performances indicate that the proposed method could be applied clinically. These results also show that the uniform approach has high versatility for providing various lesion detection processes.
• II-24 Utility of U-Net for the objective segmentation of the fibroglandular tissue region on clinical digital mammograms

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Hiorto Kimura; Takahiro Yamada; Mitsutaka Nemoto; Yuichi Kimura; Hisashi Handa; Hisashi Yoshida; Koji Abe; Masahiro Tada; Hitoshi Habe; Takashi Nagaoka; Seiun Nin; Kazunari Ishii; Yohan Kondo

  Biomedical Physics & Engineering Express IOP Publishing 8 (4) 045016 - 045016 2022/06 [Refereed]
   

  Abstract This study investigates the equivalence or compatibility between U-Net and visual segmentations of fibroglandular tissue regions by mammography experts for calculating the breast density and mean glandular dose (MGD). A total of 703 mediolateral oblique-view mammograms were used for segmentation. Two region types were set as the ground truth (determined visually): (1) one type included only the region where fibroglandular tissue was identifiable (called the ‘dense region’); (2) the other type included the region where the fibroglandular tissue may have existed in the past, provided that apparent adipose-only parts, such as the retromammary space, are excluded (the ‘diffuse region’). U-Net was trained to segment the fibroglandular tissue region with an adaptive moment estimation optimiser, five-fold cross-validated with 400 training and 100 validation mammograms, and tested with 203 mammograms. The breast density and MGD were calculated using the van Engeland and Dance formulas, respectively, and compared between U-Net and the ground truth with the Dice similarity coefficient and Bland–Altman analysis. Dice similarity coefficients between U-Net and the ground truth were 0.895 and 0.939 for the dense and diffuse regions, respectively. In the Bland–Altman analysis, no proportional or fixed errors were discovered in either the dense or diffuse region for breast density, whereas a slight proportional error was discovered in both regions for the MGD (the slopes of the regression lines were −0.0299 and −0.0443 for the dense and diffuse regions, respectively). Consequently, the U-Net and ground truth were deemed equivalent (interchangeable) for breast density and compatible (interchangeable following four simple arithmetic operations) for MGD. U-Net-based segmentation of the fibroglandular tissue region was satisfactory for both regions, providing reliable segmentation for breast density and MGD calculations. U-Net will be useful in developing a reliable individualised screening-mammography programme, instead of relying on the visual judgement of mammography experts.
• II-23 A deep learning system to diagnose COVID-19 pneumonia using masked lung CT images to avoid AI-generated COVID-19 diagnoses that include data outside the lungs

  Takashi Nagaoka; Takenori Kozuka; Takahiro Yamada; Hitoshi Habe; Mitsutaka Nemoto; Masahiro Tada; Koji Abe; Hisashi Handa; Hisashi Yoshida; Kazunari Ishii; Yuichi Kimura

  Advanced Biomedical Engineering Japanese Society for Medical and Biological Engineering 11 76 - 86 2022/03 [Refereed]
  
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• II-22 Observation of Skin Color Change by Carotenosis in Hyperlipidemia Patient

  Takashi Nagaoka

  Cardiovascular Engineering and Technology Springer Science and Business Media LLC 1869-408X 2021/05
• II-21 Clinical performance of a novel hyperspectral imaging device for cutaneous melanoma and pigmented skin lesions in Caucasian skin.

  Gustav Boelsgaard; Christensen Takashi Nagaoka; Yoshio Kiyohara; Iva Johansson Christian Ingvar; Atsushi Nakamura; Takayuki Sota; Kari Nielsen

  Skin Res Technol. 27 803 - 809 2021/03 [Refereed]
  
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• II-20 Automatic diagnosis of melanoma using hyperspectral data and GoogLeNet

  Ginji Hirano; Mitsutaka Nemoto; Yuichi Kimura; Yoshio Kiyohara; Hiroshi Koga; Naoya Yamazaki; Gustav Christensen; Christian Ingvar; Kari Nielsen; Atsushi Nakamura; Takayuki Sota; Takashi Nagaoka

  Skin Research and Technology Wiley 26 (6) 891 - 897 0909-752X 2020/11
• II-19 Hyperparameter Optimization for Deep Learning-based Automatic Melanoma Diagnosis System

  Takashi Nagaoka

  Advanced Biomedical Engineering Japanese Society for Medical and Biological Engineering 9 (0) 225 - 232 2020/08 [Refereed]
  
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• II-18 AI approach of cycle-consistent generative adversarial networks to synthesize PET images to train computer-aided diagnosis algorithm for dementia.

  Yuichi Kimura; Aya Watanabe; Takahiro Yamada; Shogo Watanabe; Takashi Nagaoka; Mitsutaka Nemoto; Koichi Miyazaki; Kohei Hanaoka; Hayato Kaida; Kazunari Ishii

  Annals of nuclear medicine 0 (0) 0 - 0 2020/07 [Refereed]
   

  OBJECTIVE: An artificial intelligence (AI)-based algorithm typically requires a considerable amount of training data; however, few training images are available for dementia with Lewy bodies and frontotemporal lobar degeneration. Therefore, this study aims to present the potential of cycle-consistent generative adversarial networks (CycleGAN) to obtain enough number of training images for AI-based computer-aided diagnosis (CAD) algorithms for diagnosing dementia. METHODS: We trained CycleGAN using 43 amyloid-negative and 45 positive images in slice-by-slice. RESULTS: The CycleGAN can be used to synthesize reasonable amyloid-positive images, and the continuity of slices was preserved. DISCUSSION: Our results show that CycleGAN has the potential to generate a sufficient number of training images for CAD of dementia.
• II-17 Performance Improvement of Automated Melanoma Diagnosis System by Data Augumentation

  Kana Kato; Mitsutaka Nemoto; Yuichi Kimura; Yoshio Kiyohara; Hiroshi Koga; Naoya Yamazaki; Gustav Christensen; Christian Ingvar; Kari Nielsen; Atsushi Nakamura; Takayuki Sota; Takashi Nagaoka

  Advanced Biomedical Engineering 9 62 - 70 2020/03 [Refereed]
  
• II-16 Automatic delineation algorithm of reference region for amyloid imaging based on kinetics.

  Takahiro Yamada; Shogo Watanabe; Takashi Nagaoka; Mitsutaka Nemoto; Kohei Hanaoka; Hayato Kaida; Kazunari Ishii; Yuichi Kimura

  Annals of nuclear medicine 34 (2) 102 - 107 2020/02 [Refereed]
   

  OBJECTIVE: This study aims to develop an algorithm named AutoRef to delineate a reference region for quantitative PET amyloid imaging. METHODS: AutoRef sets the reference region automatically using a distinguishing feature in the kinetics of reference region. This is reflected in the shapes of the tissue time activity curve. A statistical shape recognition algorithm of the gaussian mixture model is applied with considering spatial and temporal information on a reference region. We evaluate the BPND with manually set reference region and AutoRef using 86 cases (43 positive cases, 10 equivocal cases, and 33 negative cases) of dynamically scanned 11C-Pittsburgh Compound-B. RESULTS: From the Bland-Altman plot, the difference between two BPND is 0.099 ± 0.21 as standard deviation, and no significant systematic error is observed between the BPND with AutoRef and with manual definition of a reference region. Although a proportional error is detected, it is smaller than the 95% limits of agreement. Therefore, the proportional error is negligibly small. CONCLUSIONS: AutoRef presents the same performance as the manual definition of the reference region. Further, since AutoRef is more algorithmic than the ordinary manual definition of the reference region, there are few operator-oriented uncertainties in AutoRef. We thus conclude that AutoRef can be applied as an automatic delineating algorithm for the reference region in amyloid imaging.
• II-15 Quantitative cosmetic evaluation of long-lasting foundation using multispectral imaging.

  Nagaoka T; Kimura Y

  Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 25 (3) 318 - 324 0909-752X 2019/01 [Refereed]
  
• II-14 Clinical contributions of exhaled volatile organic compounds in the diagnosis of lung cancer

  Tsuyoshi Oguma; Takashi Nagaoka; Muneshige Kurahashi; Naofumi Kobayashi; Shinji Yamamori; Chizuko Tsuji; Hiroto Takiguchi; Kyoko Niimi; Hiromi Tomomatsu; Katsuyoshi Tomomatsu; Naoki Hayama; Takuya Aoki; Tetsuya Urano; Kazushige Magatani; Sunao Takeda; Tadashi Abe; Koichiro Asano

  PLOS ONE PUBLIC LIBRARY SCIENCE 12 (4) e0174802  1932-6203 2017/04 [Refereed]
   

  Background Exhaled volatile organic compounds (VOC) are being considered as biomarkers for various lungs diseases, including cancer. However, the accurate measurement of extremely low concentrations of VOC in expired air is technically challenging. We evaluated the clinical contribution of exhaled VOC measured with a new, double cold-trap method in the diagnosis of lung cancer. Methods Breath samples were collected from 116 patients with histologically confirmed lung cancer and 37 healthy volunteers (controls) after inspiration of purified air, synthesized through a cold-trap system. The exhaled VOC, trapped in the same system, were heat extracted. We analyzed 14 VOC with gas chromatography. Results The concentrations of exhaled cyclohexane and xylene were significantly higher in patients with lung cancer than in controls (p = 0.002 and 0.0001, respectively), increased significantly with the progression of the clinical stage of cancer (both p < 0.001), and decreased significantly after successful treatment of 6 patients with small cell lung cancer (p = 0.06 and 0.03, respectively). Conclusion Measurements of exhaled VOCs by a double cold-trap method may help diagnose lung cancer and monitor its progression and regression.
• III-14 生物理工学部における工学系教育へのアクティブラーニング導入の取り組みの一例

  永岡 隆

  近畿大学生物理工学部紀要 40 25 - 32 2017/03 [Refereed]
  
• II-13 Prospective Analyses of Volatile Organic Compounds in Obstructive Sleep Apnea Patients

  Takuya Aoki; Takashi Nagaoka; Naofumi Kobayashi; Muneshige Kurahashi; Chizuko Tsuji; Hiroto Takiguchi; Katsuyoshi Tomomatsu; Tsuyoshi Oguma; Naoki Kobayashi; Kazushige Magatani; Sunao Takeda; Koichiro Asano; Tadashi Abe

  TOXICOLOGICAL SCIENCES OXFORD UNIV PRESS 156 (2) 362 - 374 1096-6080 2016/12 [Refereed]
   

  Various volatile organic compounds (VOCs) are known to be toxic. Although exhaled VOC patterns change in obstructive sleep apnea (OSA) patients, individual VOC profiles are not fully determined. The primary outcome was VOC characterizations; secondary outcomes included their relationships with sleep and clinical parameters in OSA patients. We prospectively examined 32 OSA patients with an apnea-hypopnea index (AHI) >= 15 by full polysomnography, and 33 age-and sex-matched controls without obvious OSA symptoms. Nine severe OSA patients were examined before and after continuous positive airway pressure (CPAP) treatment. By applying amethod which eliminates environmental VOC influences, exhaled VOCs were identified by gas chromatography (GC)-mass spectrometry, and their concentrations were determined by GC. Exhaled aromatic hydrocarbon concentrations (toluene, ethylbenzene, p-xylene, and phenylacetic acid) in the severe OSA groups (AHI >= 30) and exhaled saturated hydrocarbon concentrations (hexane, heptane, octane, nonane, and decane) in themost severe OSA group (AHI >= 60) were higher than those in the control group. Exhaled isoprene concentrations were increased in all OSA groups (AHI >= 15); acetone concentration was increased in the most severe OSA group. Ethylbenzene, p-xylene, phenylacetic acid, and nonane concentrations were increased according to OSA severity, and correlated with AHI, arousal index, and duration of percutaneous oxygen saturation (SpO(2)) <= 90%. Multiple regression analyses revealed these 4 VOC levels were associated with the duration of SpO(2) <= 90%. Isoprene and acetone decreased after CPAP treatment. OSA increased some toxic VOCs, and some correlated with OSA severity. CPAP treatment possibly ameliorates these productions.
• III-13 Recent Advances in Diagnostic Technologies for Melanoma

  NAGAOKA Takashi

  Advanced Biomedical Engineering 5 111 - 117 2016/07 [Refereed]
  
• II-12 Portable hyperspectral imager with continuous wave green laser for identification and detection of untreated latent fingerprints on walls

  Atsushi Nakamura; Hidekazu Okuda; Takashi Nagaoka; Norimitsu Akiba; Kenji Kurosawa; Kenro Kuroki; Fumihiko Ichikawa; Akira Torao; Takayuki Sota

  FORENSIC SCIENCE INTERNATIONAL ELSEVIER IRELAND LTD 254 100 - 105 0379-0738 2015/07 [Refereed]
   

  Untreated latent fingerprints are known to exhibit fluorescence under UV laser excitation. Previously, the hyperspectral imager (HSI) has been primarily evaluated in terms of its potential to enhance the sensitivity of latent fingerprint detection following treatment by conventional chemical methods in the forensic science field. In this study however, the potential usability of the HSI for the visualization and detection of untreated latent fingerprints by measuring their inherent fluorescence under continuous wave (CW) visible laser excitation was examined. Its potential to undertake spectral separation of overlapped fingerprints was also evaluated. The excitation wavelength dependence of fluorescent images was examined using an untreated palm print on a steel based wall, and it was found that green laser excitation is superior to blue and yellow lasers' excitation for the production of high contrast fluorescence images. In addition, a spectral separation method for overlapped fingerprints/palm prints on a plaster wall was proposed using new images converted by the division and subtraction of two single wavelength images constructed based on measured hyperspectral data (HSD). In practical tests, the relative isolation of two overlapped fingerprints/palm prints was successful in twelve out of seventeen cases. Only one fingerprint/palm print was extracted for an additional three cases. These results revealed that the feasibility of overlapped fingerprint/palm print spectral separation depends on the difference in the temporal degeneration of each fluorescence spectrum. The present results demonstrate that a combination of a portable HSI and CW green laser has considerable potential for the identification and detection of untreated latent fingerprints/palm prints on the walls under study, while the use of HSD makes it practically possible for doubly overlapped fingerprints/palm prints to be separated spectrally. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
• II-11 Double Cold Trap Method to Determine the Concentrations of Volatile Organic Compounds in Human Expired Gas

  Nagaoka Takashi; Kanou Saki; Kobayashi Naofumi; Kurahashi Muneshige; Oguma Tsuyoshi; Tsuji Chizuko; Aoki Takuya; Urano Tetsuya; Magatani Kazushige; Asano Koichiro; Abe Tadashi; Takeda Sunao

  ADVANCED BIOMEDICAL ENGINEERING Japanese Society for Medical and Biological Engineering 4 112 - 118 2187-5219 2015/06 [Refereed]
   

  Volatile organic compounds (VOCs) are organic chemical substances that volatilize easily in ambient air at normal temperature and pressure. VOCs in human expired gas have been reported to be useful in the diagnosis of various diseases, but measurement of VOCs in human expired gas is technically difficult because the concentrations in expired gas are extremely low and almost the same as the concentrations in ambient air. Accurate VOC measurement usually requires a large system, and no VOC measuring systems suitable for clinical practice are available. We developed a compact, simple, double cold trap system that can measure the concentrations of VOCs originating in humans. Our system detects a limited number of VOCs with very high sensitivity at concentrations as low as 0.05 ppb. We evaluated the reproducibility of our system and measured VOCs in ambient air, purified air, and human expired gas from smokers, non-smokers, and patients. Errors of ±10% seem unavoidable in our system. Our verification experiment using human expired gas strongly suggests that the reproducibility and detection sensitivity of our system allow the detection of most VOCs in human expired gas.
• III-12 Hyperspectroscopic imager for baby fibers

  T. Nagaoka; A. Nakamura; T. Yamazaki; Y. Nakata; K. Endo; T. Sakaguchi; N. Kawata; T. Sota

  2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE 218 - 221 1557-170X 2014/08 [Refereed]
   

  Hyperspectral imaging system for diagnosing digestive diseases was newly developed in order to obtain information on pathology beyond morphology of lesions. In order to guide light reflected from a lesion, a baby fiber, which can be inserted in a forceps channel of the electronic endoscope, was also developed. The performance of the system was evaluated by animal experiment. Obtained hyperspectral data were found to have sufficient quality endurable to practical use. Harmful phenomena to a living body were not observed within the experiment. It was considered from the animal experiment that the present system could be practically used for humans.
• II-10 Modification of a melanoma discrimination index derived from hyperspectral data: a clinical trial conducted in 2 centers between March 2011 and December 2013

  T. Nagaoka; Y. Kiyohara; H. Koga; A. Nakamura; T. Saida; T. Sota

  SKIN RESEARCH AND TECHNOLOGY WILEY-BLACKWELL 21 (3) 278 - 283 0909-752X 2014/08 [Refereed]
   

  BackgroundThe morphology of pigmented skin lesions (PSLs) is predominantly a result of varying concentrations and distributions of pigmented molecules such as melanin and hemoglobin. Based on these differences and the fact that their information is contained in cutaneous spectra, a hyperspectral imager (HSI) for pigmented melanoma and a single discrimination index derived from the resultant hyperspectral data are proposed. ObjectiveTo develop and evaluate a new discrimination index for melanomas, compared to the previous index. MethodsA HSI, which is convenient for both patients and clinicians, was newly developed and used in a clinical trial conducted in 2 centers with 80 patients with primary lesions and 17 volunteers between March 2011 and December 2013. There were 24 melanomas and 110 other PSLs. A previously proposed discrimination index was used without modifications. A new index, which emphasized the essential features of melanoma, was proposed, and its performance was examined. For each index, a threshold value was set to minimize the average value of the false positive and false negative fractions. The performances of both indices were compared. ResultsThe sensitivity and specificity of the old index were 75% and 97%, respectively, while those of the new index were 96% and 87%. ConclusionThe new index had a higher sensitivity and adequate specificity, indicating that it is more useful than the old index.
• III-11 Development of a new measurement system to detect selectively volatile organic compounds derived from the human body

  S. Kanou; T. Nagaoka; N. Kobayashi; M. Kurahashi; S. Takeda; T. Aoki; T. Tsuji; T. Urano; T. Abe; K. Magatani

  Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 3837 - 3840 1557-170X 2013/07 [Refereed]
   

  A new concept expired gas measurement system used double cold-trap method was developed. The system could detect selectively volatile organic compound (VOC) derived from the human body. The gas chromatography (GC) profiles of healthy volunteer's expired gas collected by our system were analyzed. As a result, 60 VOCs were detected from the healthy volunteer's expired gas. We examined 14 VOCs among them further, which could be converted to the concentration from the GC profiles. The concentration of almost VOCs decreased when the subjects inspired purified air compared with the atmosphere. On the other hand, isoprene was almost the same. It was strongly suggested that these VOCs were derived from the human body because the concentration of these VOCs in the atmosphere were nearly zero. Expired gas of two sleep apnea syndrome (SAS) patients were analyzed as preliminary study. As a result of the study, the concentration of some VOCs contained in the expired gas of the SAS patients showed higher value than a healthy controls. © 2013 IEEE.
• II-09 Novel automated screening of age-related macular degeneration

  Yasuyuki Yamauchi; Hiroyuki Kemma; Hiroshi Goto; Atsushi Nakamura; Takashi Nagaoka; Takayuki Sota

  JAPANESE JOURNAL OF OPHTHALMOLOGY SPRINGER JAPAN KK 56 (6) 577 - 583 0021-5155 2012/10 [Refereed]
   

  To determine the objective and quantitative hyperspectral parameters for distinguishing between age-related macular degeneration (AMD) and a normal macula. Near-infrared hyperspectral images were taken of 71 eyes of 62 AMD patients with exudative AMD and 21 eyes of 12 control subjects without AMD. The spatial information included a 480 x 321-pixel image in a 50A degrees field located at the ocular fundus and a 720-950-nm-per-pixel reflectance spectrum. Macular vectors were determined as the average spectrum for each macula, and reference vectors were used as average macular vectors for healthy volunteers. Variations in vector length and angle were calculated based on comparison with the reference vector. The AMD differentiation index was a parameter that minimized the plot overlap between AMD patients and controls. Statistically significant differences between the AMD patients and controls were noted. Receiver-operating characteristic curve analysis revealed an area under the curve of 0.888. The appropriate threshold values were attained for the proposed discrimination index, including 68 % sensitivity, 95 % specificity and 74 % accuracy. This study presents a simplified diagnostic index for the determination of age-related macular degeneration based on near-infrared spectra.
• III-10 Melanoma screening system using hyperspectral imager attached to imaging fiberscope

  T. Nagaoka; A. Nakamura; Y. Kiyohara; T. Sota

  2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) IEEE 3728 - 3731 1557-170X 2012/08 [Refereed]
   

  Early detection and proper excision of the primary lesions of melanoma are crucial for reducing melanoma-related deaths. In order to support the early detection of melanoma, melanoma screening systems have been extensively studied and developed. Recently we have proposed a melanoma discrimination index derived from hyperspectral data (HSD) in the visible-near infrared wavelength region. The index represents variegation in spectra over a lesion and works well in discriminating melanoma from other pigmented lesions. However the previous hyperspectral imager did not have an enough allowance for measurement of lesions. To overcome the problem with it, we have developed a hyperspectral imager attached to imaging fiberscope. This equipment has been able to accumulate HSD in a view field of phi 40 mm within about 10 seconds, from which the above-mentioned melanoma discrimination index has been calculated. Performance of the system has been studied in nine cases of melanoma and 18 cases of non-melanoma, obtained from patients and volunteers, all of whom were Japanese. The index has achieved a sensitivity of 100 % and a specificity of 94.4 %.
• II-08 Hyperspectroscopic screening of melanoma on acral volar skin

  Takashi Nagaoka; Atsushi Nakamura; Haruka Okutani; Yoshio Kiyohara; Hiroshi Koga; Toshiaki Saida; Takayuki Sota

  SKIN RESEARCH AND TECHNOLOGY WILEY-BLACKWELL 19 (1) E290 - E296 0909-752X 2012/06 [Refereed]
   

  Background/purpose: Early detection and proper excision of the primary lesions of melanoma are crucial for reducing melanoma-related deaths. To support the early detection of melanoma, automated melanoma-screening systems have been extensively studied and developed. In this article, a previously reported hyperspectral imager and melanoma discrimination index are applied to the discrimination of acral lentiginous melanoma (ALM) from acral nevus (AN), and their diagnostic performance is reported. Methods: The index expresses the disordered nature of each lesion including variegation in color based on variation in spectral information obtained from each lesion. Performance of the index has been studied in thirteen cases of ALM and seven cases of AN, obtained from patients and volunteers, all of whom were Japanese. Results: The index discriminated ALM from AN with a sensitivity of 92% and a specificity of 86%. The area under the receiver operating characteristic curve was 0.97. Conclusion: The performance of the proposed objective melanoma discrimination index at a molecular pigmentary level approached that of clinical experts, using the three-step algorithm as the gold standard.
• II-07 A possible melanoma discrimination index based on hyperspectral data: a pilot study

  Takashi Nagaoka; Atsushi Nakamura; Haruka Okutani; Yoshio Kiyohara; Takayuki Sota

  SKIN RESEARCH AND TECHNOLOGY WILEY-BLACKWELL 18 (3) 301 - 310 0909-752X 2011/08 [Refereed]
   

  Background Early detection and proper excision of the primary lesions of malignant melanoma (MM) are crucial for reducing melanoma-related deaths. To support the early detection of melanoma, automated melanoma screening systems have been extensively studied and developed. In this article, we present a hyperspectral melanoma screening system and propose a possible melanoma discrimination index derived from the characteristics of the pigment molecules in the skin, both of which have been derived from hyperspectral data (HSD). Methods The index expresses the disordered nature of each lesion including variegation in color based on variation in spectral information obtained from each lesion. Performance of the index in discriminating melanomas from other pigmented skin lesions has been studied in five cases of melanoma (41 HSD sets), one case of Spitz nevus (13 HSD sets), 10 cases of seborrheic keratosis (78 HSD sets), three cases of basal cell carcinoma (16 HSD sets), and nine cases of melanocytic nevus (21 HSD sets), obtained from patients and volunteers, all of whom were Japanese. Results Performance of the index, which reflects the disordered nature of a lesion, discriminates melanomas with a sensitivity of 90%, a specificity of 84%, and an area under the receiver operating characteristic curve of 0.93, on resubstitution. Conclusion An objective melanoma discrimination index at a molecular pigmentary level, derived from HSD, has been proposed, and its performance evaluated. This index was highly successful in discriminating MM from non-melanoma, although the statistical population was small.
• II-06 Novel melanoma discrimination index from optical spectra

  OKUTANI Haruka; NAKAMURA Atsushi; NAGAOKA Takashi; KIYOHARA Yoshio; SOTA Takayuki

  Skin Cancer The Japanese Skin Cancer Society 26 (1) 94 - 97 0915-3535 2011/01 [Refereed]
   

  The ABCD-rule of dermoscopy has increased diagnostic accuracy ; however, some training is required in using it efficiently, and the diagnosis based on morphology is to a large extent subjective as with any clinical diagnosis. Morphology mainly comes from spatial variegation in skin pigmentation, i.e. spatial change in pigment molecular species and their concentration. Optical spectra reflected from the skin carry information about it. An essential feature of melanoma is the variety in morphology of the lesion, which is equivalent to change in spectrum from portion to portion within the lesion. The hyperspectral imaging technique enables one to measure hyperspectral data (HSD) within a short period, which consist of both spatial and spectral information. In this paper, we propose a single melanoma discrimination index derived from HSD using the entropy concept, and demonstrate its usefulness.[Skin Cancer (Japan) 2011 ; 26 : 94-97]
• II-05 A melanoma discrimination index based on optical spectra

  NAGAOKA Takashi; NAKAMURA Atsushi; AIZAWA Katsuo; OHTSUBO Shinya; KIYOHARA Yoshio; SOTA Takayuki

  Skin Cancer The Japanese Skin Cancer Society 25 (1) 81 - 84 0915-3535 2010/01 [Refereed]
   

  The morphology of pigmented skin lesions (PSLs) comes from differences in distribution and in concentration of melanin and hemoglobin pigment molecules. Those differences may be analyzed qualitatively and quantitatively using diffuse reflectance spectra in the visible to near infrared wavelength region. We have expressed differences in concentration distribution of both pigment molecules numerically with the use of diffuse reflectance spectra varying from site to site. Performance of the parameter has been studied on fifteen cases of PSLs : six cases of melanoma, five cases of seborrheic keratosis, and four cases of nevus. It has been demonstrated that the parameter can discriminate melanoma from others with a sensitivity of 85% and a specificity of 91%. It has also been suggested that the parameter reflects both boundary irregularity and variation in colors of PSLs.[Skin Cancer (Japan) 2010 ; 25 : 81-84]
• III-09 Development of blood vessel viewer using multi spectral imaging technology

  Takashi Nagaoka; Atsushi Nakamura; Katsuo Aizawa; Shinya Ohtsubo; Toru Mochizuki; Yoshio Kiyohara; Takayuki Sota

  2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8 IEEE 2008 1234 - + 1557-170X 2008/08 [Refereed]
   

  Using multi spectral imaging technology, which enable us to simultaneously obtain spatial and wavelength information, we have newly developed blood vessel viewer. Our device is composed of the light source, the lens or the endoscope, the optical device, CCD camera, and PC. As an evaluation of our device, we measured the skin diffuse reflectance spectrum of the human hand. The blood vessel observed by our device was corresponding to an anatomy finding. However, even if Principal Component Analysis was used, the reflection of horny was not able to be removed completely.
• III-08 Inspection of skin hemodynamics with hyperspectral camera.

  Nagaoka T; Eikje NS; Nakamura A; Aizawa K; Kiyohara Y; Ichikawa F; Yamazaki T; Doi M; Nakamura K; Otsubo S; Sota T

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2007 3357 - 3361 1557-170X 2007/08 [Refereed]
  
• III-07 Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system

  Hironori Suzaki; Naoki Kobayashi; Takashi Nagaoka; Kiyotaka Iwasaki; Mitsuo Umezu; Sunao Takeda; Tatsuo Togawa

  2006 International Conference of the IEEE Engineering in Medicine and Biology Society IEEE 1 799 - 802 0589-1019 2006/08 [Refereed]
   

  Total hemoglobin (tHb), carboxyhemoglobin (COHb), and methemoglobin (MetHb) are usually measured with a CO-oximeter. Noninvasive and continuous measurement of these blood components is expected to decrease the pain of a patient. Therefore, we developed an instrument to measure oxygen saturation (SpO 2), tHb, COHb, and MetHb non-invasively. Multiwavelength LED (600, 625, 660, 760, 800, 940, and 1300 nm) and a combined detector (Si, InGaAs) were built into the instrument (Seven wavelengths transparent pulse spectrophotometer). We used the Waseda mock circulatory system, which can simulate blood circulation in tissues and generate a pulse wave mechanically, to estimate the instrument's performance. Furthermore we proposed new calculation formula including DC components of optical density (this method). Under conditions without any change of other components, the mean error ± standard deviation between this method and the CO-oximetry were SaO 2=0.0±1.4%, tHb=0.0±0.0 g/dl, COHb=0.0±2.0%, and MetHb=0.0±0.3%. When the concentration of other components was changed, this method showed mean errors and standard deviations of SaO 2=0.2±1.6%, tHb=0.0±0.4 g/dl, COHb=0.5±4.1%, and MetHb=0.0±0.3%. © 2006 IEEE.
• III-06 Relation between hematocrit and optical density in pulse oximetry -In vitro study with Waseda mock circulatory system-

  H. Suzaki; S. Takeda; N. Kobayashi; H. Kubota; T. Aomi; T. Nagaoka; K. Iwasaki; M. Umezu; A. Uchiyama

  2005 IEEE Engineering in Medicine and Biology 27th Annual Conference IEEE 2005/09 [Refereed]
  
• III-05 Development of a small wireless position and bleeding detection sensor

  T Nagaoka; A Uchiyama

  2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology IEEE 130 - 131 2005/05 [Refereed]
   

  Medical capsule devices such as video capsule endoscopes are finding increasing use in clinical applications. At present, technologies capable of measuring capsule position and detecting a bleeding in the digestive tract at the same time have not yet been established. The present study aims to develop a small wireless position and bleeding detection sensor. The sensor position are measured by using the phenomenon of mutual induction and Newton's law. Electromotive forces induced in the sensor are modulated to FM signals using an astable multivibrator, and the signals are passed directly through living tissue at low current and then demodulated by detectors on the surface of the body. A prototype sensor was developed and evaluated in vitro. The sensor was capable of accurately measuring capsule position up to 500 (mm) from the primary coils with an accuracy of 5 (mm), and detecting 0.5 cc blood in 500 cc physiological saline.
• II-04 Development and Application of a Three-dimensional Position Sensor Using a Permanent Magnet

  NAGAOKA Takashi; ICHIKAWA Daisuke; UCHIYAMA Akihiko

  Transactions of the Japanese Society for Medical and Biological Engineering : BME Japanese Society for Medical and Biological Engineering 42 (4) 300 - 306 1347-443X 2004/08 [Refereed]
   

  In recent years, the number of patients complaining of abnormal bowel movements has increased, and the incidence of abnormal bowel movements in the Japanese population over the age of 15 years old has been estimated to have increased to approximately 20%. Clarification of the intestinal peristalsis of the digestive tract is important for elucidating the pathology of digestive disorders. Existing assessment systems have problems with quantification and reproducibility. With this background, the present study was conducted to develop a system for analyzing intestinal peristalsis using three-dimensional (3D) position sensors. By creating 3D position sensors out of permanent magnets, we were able to directly measure the movements of intestinal contents and assess the state of intestinal peristalsis using strain gauges attached to the intestinal wall. The results of in vitro experiments showed that the maximum measurement error was 6.5mm within 250mm of the sensor. A preliminary animal study was conducted using wired position sensors. Radiographic findings showed that the sensors detected the movement of the intestinal contents, and the movement detected by the sensors correlated with the output of the strain gauges attached to the intestinal wall.
• III-04 Development of noninvasive tonometer using resonance phenomenon

  M. Nakai; T. Nagaoka; I. Yoshizawa; A. Fujita; S. Takeda; K. Yanasima; A. Uchiyama

  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 26 III 2055 - 2058 0589-1019 2004/08 [Refereed]
   

  A tonometer is used to measure ocular pressure either by shooting a short blast of compressed air onto the cornea or by applying pressure directly to the cornea. At present, the tonometer is the primary instrument available for measuring ocular pressure. However, measuring ocular pressure by such means can either frighten or injure the patient. We propose an improved method of measuring ocular pressure in which the tonometer is applied over the patient's closed eyelid for several seconds. The sensor part of the newly developed tonometer contains a bimorph type transducer and weighs only 28.7 (g). When the sensor is placed on the eyelid and the transducer is vibrated by altering the applied voltage, the current flowing through the transducer changes in relation to the ocular pressure. Ocular pressure can thus be determined based on the current flowing through the system. During measurement, patients are generally unaware of the vibrations of the sensor and report no pain.
• III-03 Development of a small wireless position sensor for medical capsule devices

  T. Nagaoka; A. Uchiyama

  Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 26 III 2137 - 2140 0589-1019 2004/08 [Refereed]
   

  Medical capsule devices such as video capsule endoscopes are finding increasing use in clinical applications. At present, technologies capable of measuring capsule position in the digestive tract have not yet been established. The present study aims to develop a small wireless position sensor capable of measuring capsule position based on the phenomenon of mutual induction. Currents into primary coils are adjusted to maintain electromotive force induced in secondary coils at a constant level. Electromotive forces induced in the secondary coils are modulated to FM signals using an astable multivibrator, and the signals are passed directly through living tissue at low current and then demodulated by detectors on the surface of the body. A prototype wireless sensor was developed and evaluated in vitro. The sensor was capable of accurately measuring capsule position up to 500 (mm) from the primary coils with an accuracy of 5 (mm). Miniaturization of the sensor is necessary for commercialization.
• II-03 Trial of Wireless 3-D Position Sensor

  Takashi Nagaoka; Akihiko Uchiyama

  IEEJ Transactions on Electronics, Information and Systems The Institute of Electrical Engineers of Japan 124 (7) 1352 - 1358 1348-8155 2004/07 [Refereed]
   

  We developed wireless 3-D position sensor. Although we reported a wired position sensor, in order that the wire might affect movement of the sensor, we develop a wireless position sensor newly. For inspection of position measurement algorithm, we first developed a trial product of wireless capsule type sensor without regard to size. The position of the sensor was detected by using mutual induction. In order to maintain the electromotive force induced at secondary coils in the sensor constant, the current flowing into the primary coil was regulated using feedback control. The position of the sensor was measured stably using the feedback control, even when the sensor was relatively far from the primary coil. Induced electromotive forces are modulated to FM signals by using astable multivibrator and the FM signal is flowed into a living body directly with low current, and demodulated from electrode on body surface. The position of the sensor was determined from the current flowing into the primary coil. As a re ult of accuracy evaluation of the sensor in vitro, the error was 2.17±0.99 mm (Ave±S.D.) in a range of up to 1 m from the magnetic field generator. This sensor is applicable to medical capsule devices, such as capsule endoscope. © 2004, The Institute of Electrical Engineers of Japan. All rights reserved.
• II-02 Fabrication of Three-Dimensional Position-Measurement Sensor Using a Single-Axis Coil

  Nagaoka T; Uchiyama A

  Journal of Magnetics Society of Japan 公益社団法人日本磁気学会 28;2 (2) 97 - 101 1880-4004 2004/04 [Refereed]
   

  This paper proposes a new sensing method that can measure three-dimensional position inside a living body, using a magnetic field. This method is applicable to medical capsule devices, such as the capsule endoscope. The mutual induction phenomenon is used for position measurement. In order to hold constant the induced electromotive force that occurs in the secondary coil, we apply feedback control to the alternating current flowing into the primary coil. This method enables stable measurement of sensor position, even if the sensor exists relatively far from the primary coils. The position of the sensor is measured by calculating six formulas using Newton's method. The relationship between the induced electromotive force and the theoretical value of the magnetic field is determined in advance. Sensor in vitro accuracy was verified. For distances of less than 300 mm from the sensor to the magnetic field generator, the distance error was less than 7 mm. Although a wireless sensor would be ideal, the present sensor is connected to the computer through a thin cable. Development of wireless sensor should be the next research subject.
• III-02 Development of three-dimensional position sensor for the digestive tract

  T Nagaoka; A Uchiyama

  IEEE EMBS APBME 2003 IEEE 266 - 267 2003/10 [Refereed]
   

  Video capsule endoscopes are partly applied to clinical use. However, measurement technologies of capsule position in the digestive tract are not established yet. Therefore, the purpose or this study is to develop three-dimensional position sensor which can measure capsule position in the digestive tract. Three coils are arranged perpendicular in the capsule. The sensor generates electromotive force induced by magnetic field generator placed outside of a living body. By measuring induced electromotive force, we can calculate the distance between the sensor and the magnetic field generator. Although wireless is an ideal method for position measurements of capsule endoseope, this sensor is connected to computer through a thin cable because of electric power requirement.
• II-01 Development of a Three-Dimensional Position Sensor for Digestive Tract Measurement

  NAGAOKA Takashi; TAKEDA Sunao; UCHIYAMA Akihiko

  Transactions of the Japanese Society for Medical and Biological Engineering : BME Japanese Society for Medical and Biological Engineering 41 (4) 239 - 249 1347-443X 2003/08 [Refereed]
   

  We developed a three-dimensional position sensor that can measure the position of a capsule in the digestive tract. For the purpose of inspecting a new position measurement algorithm, we first developed a prototype wired capsule-type sensor that is capable of being swallowed. Our ultimate goal will be to develop a wireless sensor. The current sensor is applicable for medical capsule devices, such as capsule endoscope. The position of the sensor was detected using mutual induction. In order to maintain the electromotive force induced at secondary coils in the sensor constant, the current flowing into the primary coil was regulated using feedback control. The position of the sensor was measured stably using the feedback control, even when the sensor was relatively far from the primary coil. The position of the sensor was determined from the current flowing into the primary coil. As a result of evaluating the accuracy of the wired sensor in vitro, the error was 2.90 ± 2.10 mm (Ave.± S. D.) in a range of up to 1m from the magnetic field generator. Moreover, using a new position compensation algorithm, we were able to remove distortion caused by the magnetic field.
• III-01 3D Analysis of the Alignment of the Lower Extremity in High Tibial Osteotomy.

  Hideo Kawakami; Nobuhiko Sugano; Takashi Nagaoka; Keisuke Hagio; Kazuo Yonenobu; Hideki Yoshikawa; Takahiro Ochi; Asaki Hattori; Naoki Suzuki

  Medical Image Computing and Computer-Assisted Intervention - MICCAI 2002, 5th International Conference, Tokyo, Japan, September 25-28, 2002, Proceedings, Part II Springer 261 - 267 2002/09 [Refereed]
  

Books etc

• I-1 生命・医療・福祉ハンドブック

  早稲田大学生命; 生体; 福祉研究所 (Joint work眼圧計, カプセル型内視鏡, 超音波診断, 超音波破砕, 放射線治療)コロナ社 2007/02

Conference Activities & Talks

• (066) DP 生成系AIを用いた読影医によるアノテーション不要なFDG-PET/CT像の肺病変強調手法

  大谷 和暉; 根本 充貴; 甲斐田 勇人; 瀬川 新; 木村 裕一; 永岡 隆; 三上 勝大; 山田 誉大; 花岡 宏平; 槌谷 達也; 北島 一宏; 石井 一成

  第63回日本核医学会学術総会  2023/11
• (065) DP AIで生成したアミロイド画像におけるスライス間の連続性の評価

  渡邉 綾; 山田 誉大; 永岡 隆; 根本 充貴; 渡部 浩司; 茨木 正信; 松原 佳亮; 花岡 宏平; 甲斐田 勇人; 石井 一成; 木村 裕一

  第63回日本核医学会学術総会  2023/11
• (064) DP 教師無し深層画像生成を用いた FDG-PET/CT 像上の肺病変検出  [Not invited]

  瀬川新; 根本充貴; 甲斐田勇人; 木村裕一; 永岡隆; 三上勝大; 山田誉大; 花岡宏平; 北島一宏; 槌谷達也; 石井一成

  生体医工学シンポジウム2023  2023/09
• (063) DP スタイル変換による加増がメラノーマ自動診断システムの性能に与える影響  [Not invited]

  飛塚丈輝; 正木達也; 北畠直人; 花崎和寿; 張維倫; 永岡隆

  生体医工学シンポジウム2023  2023/09
• (062) DP 自動機械学習を用いたメラノーマ診断システムのパラメータ調整による性能向上  [Not invited]

  正木達也; 北畠直人; 飛塚丈輝; 花崎和寿; 張 維倫; 永岡 隆

  生体医工学シンポジウム2023  2023/09
• (061) DP ハイパースペクトルデータからのメラノーマ抽出と自動診断への応用  [Not invited]

  北畠直人; 飛塚丈輝; 花崎和寿; 正木達也; 張 維倫; 永岡 隆

  生体医工学シンポジウム2023  2023/09
• (060) DP 縁を付与したメラノーマ画像を用いた深層学習による病変抽出  [Not invited]

  花崎和寿; 北畠直人; 飛塚丈輝; 正木達也; 張維倫; 永岡隆

  生体医工学シンポジウム2023  2023/09
• (059) DP 肺マスク層を有する 3D-CNN を用いた COVID-19 診断システムの開発  [Not invited]

  張 維倫; 北畠 直人; 飛塚 丈輝; 正木 達也; 花崎 和寿; 永岡 隆

  生体医工学シンポジウム2023  2023/09
• (058) DP Contrastive learning と 2.5 次元画像解析による診断支援システム画像特徴量の生成に関する検討  [Not invited]

  細田和史; 根本充貴; 木村裕一; 永岡隆; 三上勝大; 吉川健啓

  生体医工学シンポジウム2023  2023/09
• (031) IP Improving performance of melanoma automated diagnosis system with style transfer  [Not invited]

  Takeki Tobitsuka; Naoto Kitabata; Tatsuya Masaki; Kazutoshi Hanazaki; Wei Lun Chang; Nagaoka Takashi

  45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2023)  2023/07
• (030) IP Segmentation of pigmented skin lesions considering features of dermoscopic images  [Not invited]

  Kazutoshi Hanazaki; Naoto Kitabata; Takeki Tobitsuka; Tatsuya Masaki; Wei Lun Chang; Takashi Nagaoka

  45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2023)  2023/07
• (096) DO 生成系 AI を用いた読影医によるアノテーション不要な FDG-PET/CT 像の肺病変強調手法  [Not invited]

  大谷 和暉; 根本 充貴; 甲斐田 勇人; 瀬川 新; 木村 裕一; 永岡 隆; 三上 勝大; 山田 誉大; 花岡 宏平; 槌谷 達也; 北島 一宏; 石井 一成

  第5回日本核医学会近畿支部会  2023/07
• (095) DO アミロイド PET 撮像判断のための生成系 AI による FDG 画像からのアミロイド画像合成の検討  [Not invited]

  本田 実沙; 山田 誉大; 永岡 隆; 三上 勝大; 根本 充貴; 花岡 宏平; 甲斐田 勇人; 石井 一成; 木村 裕一

  第5回日本核医学会近畿支部会  2023/07
• (094b) DO 診断情報を後ろ向き利用した胸部CT画像上肺結節領域の自動推定～医師によるアノテーションの負荷が少ない胸部画像診断AI開発に向けた一検討～  [Not invited]

  村中 皓紀; 根本 充貴; 木村 裕一; 永岡 隆; 三上 勝大; 吉川 健啓

  一般社団法人和歌山県臨床工学技士会第 28 回学術集会  2023/06
• (094a) DO U-netを用いた全身CT像上骨領域抽出～FDG-PET/CT像上多種がん骨転移検出AIに向けた検討～  [Not invited]

  佐原 詢之佑; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 三上 勝大; 山田 誉大; 花岡 宏平; 槌谷 達也; 北島 一宏; 石井 一成

  一般社団法人和歌山県臨床工学技士会第 28 回学術集会  2023/06
• (057) DP 3D-CNN と肺マスク画像を用いた COVID-19 診断システムの開発  [Not invited]

  張 維倫; 飛塚 丈輝; 正木 達也; 北畠 直人; 花崎 和寿; 永岡 隆

  第62回日本生体医工学会大会  2023/05
• (056) DP AutoML を用いたメラノーマ診断システムのデータ加増による性能向上  [Not invited]

  正木 達也; 北畠 直人; 飛塚 丈輝; 花崎 和寿; 張 維倫; 永岡 隆

  第62回日本生体医工学会大会  2023/05
• (055) DP ハイパースペクトラルデータと 3D u-net を用いたメラノーマ病変部抽出  [Not invited]

  北畠 直人; 飛塚 丈輝; 正木 達也; 花崎 和寿; 張 維倫; 永岡 隆

  第62回日本生体医工学会大会  2023/05
• (054) DP スタイル変換における加増パターンの違いに対するメラノーマ自動診断システムの性能変化  [Not invited]

  飛塚 丈輝; 正木 達也; 北畠 直人; 花崎 和寿; 張 維倫; 永岡 隆

  第62回日本生体医工学会大会  2023/05
• (053) DP 深層学習を用いたメラノーマの病変部抽出  [Not invited]

  花崎 和寿; 北畠 直人; 飛塚 丈輝; 正木 達也; 張 維倫; 永岡 隆

  第62回日本生体医工学会大会  2023/05
• (094) DO Pix2Pix 画像スタイル変換を用いた教師無し異常検知による FDG-PET/CT 像上肺病変強調  [Not invited]

  大谷 和暉; 根本 充貴; 甲斐田 勇人; 瀬川 新; 中前 由香子; 村中 皓紀; 吉田 昂平; 木村 裕一; 永岡 隆; 三上 勝大; 山田 誉大; 花岡 宏平; 槌谷 達也; 北島 一宏; 石井 一成

  第62回日本生体医工学会大会  2023/05
• (093) DO U-Net を用いた CT 像上肝臓および腎臓領域の同時抽出～腹部 PET/CT 像上病変検出に向けた検討～  [Not invited]

  吉田 昂平; 根本 充貴; 甲斐田 勇人; 瀬川 新; 中前 有香子; 村中 晧紀; 大谷 和暉; 木村 裕一; 永岡 隆; 山田 誉大; 花岡 宏平; 槌谷 達也; 北島 一宏; 石井 一成

  第62回日本生体医工学会大会  2023/05
• (092) DO AI 診断システム開発用病変ラベル作成負荷低減に向けた弱教師とマルチウィンドウ CT 像解析による肺結節領域推定  [Not invited]

  村中 皓紀; 根本 充貴; 木村 裕一; 永岡 隆; 細田 和史; 中前 有香子; 大谷 和暉; 吉田 昂平; 吉川 健啓

  第62回日本生体医工学会大会  2023/05
• (057b) DP U-Netを用いたCT像上肝臓および腎臓領域の同時抽出～腹部PET/CT像上病変検出に向けた検討～

  吉田昂平; 根本充貴; 甲斐田勇人; 瀬川新; 中前有香子; 村中皓紀; 大谷和暉; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 槌谷達也; 北島一宏; 石井一成

  第62回日本生体医工学会大会  2023/05
• (057a) DP Pix2Pix画像スタイル変換を用いた教師無し異常検知による FDG-PET/CT像上肺病変強調

  大谷和暉; 根本充貴; 甲斐田勇人; 瀬川新; 中前有香子; 村中皓紀; 吉田昂平; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 槌谷達也; 北島一宏; 石井一成

  第62回日本生体医工学会大会  2023/05
• (091)DO 3D-CNNを用いたCOVID-19診断システムの開発  [Not invited]

  張 維倫; 飛塚丈輝; 正木達也; 北畠直人; 花崎和寿; 永岡 隆

  メディカルイメージング連合フォーラム  2023/03
• (090)DO Auto MLを用いたメラノーマ診断システムの性能向上  [Not invited]

  正木達也; 北畠直人; 飛塚丈輝; 花崎和寿; 張 維倫; 永岡 隆

  メディカルイメージング連合フォーラム  2023/03
• (089)DO スタイル変換によるメラノーマ自動診断システムの性能向上  [Not invited]

  飛塚丈輝; 正木達也; 北畠直人; 花崎和寿; 張 維倫; 永岡 隆

  メディカルイメージング連合フォーラム  2023/03
• (088)DO ハイパースペクトラルデータとDeeplabv3+を用いたメラノーマ病変部抽出  [Not invited]

  北畠直人; 飛塚丈輝; 正木達也; 花崎和寿; 張 維倫; 永岡 隆

  メディカルイメージング連合フォーラム  2023/03
• (087)DO ダーモスコピーの縁を考慮に入れたメラノーマの病変抽出  [Not invited]

  花崎和寿; 北畠直人; 飛塚丈輝; 正木達也; 張 維倫; 永岡 隆

  メディカルイメージング連合フォーラム  2023/03
• (086)DO pix2pixを用いたメラノーマの病変領域抽出  [Not invited]

  永岡 隆; 根本充貴; 三上勝大; 篠原寿広; 木村裕一

  メディカルイメージング連合フォーラム  2023/03
• (085b) DO フラクタルデータベースを用いた胸部CT画像の肺炎識別器の事前学習  [Not invited]

  吉岡雄健; 舩津朋和; 永岡隆; 小塚健倫; 根本充貴; 山田誉大; 木村裕一; 石井一成; 波部斉

  情報処理学会第85回全国大会  2023/03
• (029d) IP Pre-training of Pneumonia Classifier for Chest CT images using Fractal Database

  Yuken Yoshioka; Daichi Ikefuji; Tomokazu Funatsu; Takashi Nagaoka; Takenori Kozuka; Mitsutaka Nemoto; Takahiro Yamada; Yuichi Kimura; Kazunari Ishii; Hitoshi Habe

  The 29th International Workshop on Frontiers of Computer Vision (IW-FCV2023) Online Proceeding  2023/02
• (029c) IP Detection of Bone Metastasis on FDG-PET/CT Images using Multi-step Anomaly Voxel Detection and Local Patch analysis with Unsupervised Deep Features and Image Textures

  Yamaguchi H; Nemoto M; Kaida H; Kimura Y; Nagaoka T; Yamada T; Hanaoka K; Kitajima K; Tsuchitani T; Ishii K

  13th World Federation of Nuclear Medicine and Biology  2022/09
• (029b) IP Study for detecting pulmonary nodules on FDG-PET/CT images with training small dataset

  Segawa A; Nemoto M; Kaida H; Kimura Y; Nagaoka T; Yamaguchi H; Nakamae Y; Yamada T; Hanaoka K; Kitajima K; Tsuchitani T; Ishii K

  13th World Federation of Nuclear Medicine and Biology  2022/09
• (029a) IP Evaluation on Applicability of Generative Adversarial Network to Synthesize Training Images for AI-Based Computer Aided Diagnostic Algorithm to Dementia

  Watanabe A; Yamada T; Nagaoka T; Nemoto M; Watabe H; Ibaraki M; Matsubara K; Hanaoka K; Ishii K; Kimura Y

  13th World Federation of Nuclear Medicine and Biology  2022/09
• (029)IP Robustness of a U-net model for different image processing types in segmentation of the mammary gland region

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Hiroto Kimura; Takahiro Yamada; Mitsutaka Nemoto; Yuichi Kimura; Hisashi Handa; Hisashi Yoshida; Koji Abe; Masahiro Tada; Hitoshi Habe; Takashi Nagaoka; Seiun Nin; Kazunari Ishii; Yongbum Lee

  16th International Workshop on Breast Imaging (IWBI2022)  2022/07  SPIE
  
• (049)DP スタイル変換を用いた加増によるメラノーマ自動診断システムの性能向上  [Not invited]

  飛塚丈輝; 正木達也; 花崎和寿; 北畠直人; 永岡 隆

  第61回日本生体医工学会大会  2022/06
• (048)DP 深層学習を用いたメラノーマ診断システムのデータ加増による性能向上  [Not invited]

  正木達也; 飛塚丈輝; 花崎和寿; 北畠直人; 永岡 隆

  第61回日本生体医工学会大会  2022/06
• (047)DP 線形判別分析を用いたメラノーマの領域抽出とその診断性能への影響  [Not invited]

  北畠直人; 正木達也; 飛塚丈輝; 花崎和寿; 永岡 隆

  第61回日本生体医工学会大会  2022/06
• (046)DP メラノーマの病変部抽出

  花崎和寿; 飛塚丈輝; 正木達也; 北畠直人; 永岡 隆

  第61回日本生体医工学会大会  2022/06
• (050)DP 深層画像生成技術を用いたFDG-PET/CT像異常検知による病変強調

  瀬川新; 根本充貴; 甲斐田勇人; 甲斐田勇人; 山口明乃; 木村裕一; 永岡隆; 山田誉大; 北島一宏; 石井一成; 石井一成

  日本生体医工学会大会プログラム・抄録集(Web)  2022/06
• (051)DP CT画像テクスチャと患者情報のAI解析による体外衝撃波結石破砕術の結果予測

  中前有香子; 根本充貴; 木村裕一; 木村裕一; 永岡隆; 永岡隆; 出口龍良; 山下真平; 柑本康夫; 原勲

  日本生体医工学会大会プログラム・抄録集(Web)  2022/06
• (052)DP 画素異常検知と深層教師なし特徴抽出によるFDG-PET/CT像上がん骨転移検出

  山口明乃; 根本充貴; 甲斐田勇人; 甲斐田勇人; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成

  日本生体医工学会大会プログラム・抄録集(Web)  2022/06
• (085a) 学習時の注目領域重視度の動的調整による画像分類精度の改善  [Not invited]

  舩津朋和; 波部 斉; 永岡 隆; 小塚健倫; 根本充貴; 山田誉大; 吉田 久; 木村裕一; 石井一成

  情報処理学会第84回全国大会  2022/03
• (084)DO 2種類の異常検知を用いたFDG-PET/CT像上のがん骨転移病変自動検出

  山口明乃; 根本充貴; 甲斐田勇人; 甲斐田勇人; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成

  核医学(Web)  2021/11
• (085)DO 敵対的生成ネットワークで合成したPET画像における定量性の検討

  渡邉綾; 木村裕一; 山田誉大; 渡辺翔吾; 永岡隆; 根本充貴; 宮崎晃一; 花岡宏平; 甲斐田勇人; 甲斐田勇人; 石井一成; 石井一成

  核医学(Web)  2021/11
• (028)IP [CAR-PO-23] 001 Can radiological technologists create training data for automatically segmenting the mammary gland region in non-dense breasts?  [Not invited]

  M. Yamamuro; Y. Asai; N. Hashimoto; N. Yasuda; Y. Ozaki; S. Nin; K. Ishii; T. Yamada; M. Nemoto; Y. Kimura; H. Handa; H. Yoshida; K. Abe; M. Tada; H. Habe; T. Nagaoka; Y. Lee

  CARS2021  2021/06
• (027)IP [CAD-PO-61] 033 Detection of bone metastases on FDG-PET/CT images by using two-step anomaly detection  [Not invited]

  H. Yamaguchi; M. Nemoto; H. Kaida; Y. Kimura; T. Nagaoka; T. Yamada; K. Hanaoka; K. Kitajima; T. Tsuchitani; K. Ishii

  CARS2021  2021/06
• (083)DO O1-5-3-5 CT 画像によるCOVID-19 性肺炎診断支援システムKindAI-COVID の開発  [Not invited]

  永岡 隆; 小塚 健倫; 根本 充貴; 波部 斉; 山田 誉大; 吉田 久; 木村 裕一; 石井 一成

  第60回日本生体医工学会大会  2021/06
• (082)DO O1-5-4-4 2 種類のAI 異常検知カスケードを用いたFDG-PET/CT 像上がん骨転移検出  [Not invited]

  山口 明乃; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 山田 誉大; 花岡宏平; 北島 一宏; 槌谷 達也; 石井 一成

  第60回日本生体医工学会大会  2021/06
• (081)DO O1-5-3-3 CT 画像上のテクスチャ解析によるESWL 治療可能な尿路結石の自動認識  [Not invited]

  中前 有香子; 根本 充貴; 木村 裕一; 永岡 隆; 山田 誉大; 出口 龍良; 山下真平; 柑本 康夫; 原 勲

  第60回日本生体医工学会大会  2021/06
• (080)DO O1-5-2-4 認知症診断AI アルゴリズム学習のためのCycleGAN で合成したPET 画像の定量的検証  [Not invited]

  渡邉 綾; 山田 誉大; 渡辺 翔吾; 永岡 隆; 根本 充貴; 宮崎 晃一; 花岡 宏平; 甲斐田 勇人; 石井 一成; 木村 裕一

  第60回日本生体医工学会大会  2021/06
• (079)DO 深層学習によるメラノーマの自動診断 ～ HSDの主成分分析による次元縮約 ～  [Not invited]

  金澤祐斗; 永岡 隆; 木村裕一; 根本充貴

  メディカルイメージング連合フォーラム  2021/03
• (26b) IP How to select training data to segment mammary gland region using a deep-learning approach for reliable individualized screening mammography  [Not invited]

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Takahiro Yamada; Mitsutaka Nemoto; Yuichi Kimura; Hisashi Handa; Hisashi Yoshida; Koji Abe; Masahiro Tada; Hitoshi Habe; Takashi Nagaoka; Yoshiaki Ozaki; Seiun Nin; Kazunari Ishii; Yongbum Lee

  Medical Imaging 2021: Computer-Aided Diagnosis  2021/02  SPIE
  
• (078)DO One-class SVMを用いた異常検知によるPET/CT上の骨転移病変自動検出  [Not invited]

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 牛房 和之; 山田 誉大; 花岡 宏平; 北島 一宏; 槌谷 達也; 石井 一成

  第60回日本核医学学術総会  2020/11
• (077)DO 認知症自動診断AIアルゴリズム学習のための深層学習により加増したアミロイド画像の検証

  渡邉 綾; 木村 裕一; 山田 誉大; 渡辺 翔吾; 永岡 隆; 根本 充貴; 宮崎 晃一; 花岡 宏平; 甲斐田 勇人; 石井 一成

  第60回日本核医学学術総会  2020/11
• (076)DO 深層学習を用いたメラノーマの自動診断システムの開発 ～ 病変部位強調画像の採用 ～  [Not invited]

  平野銀次; 根本充貴; 木村裕一; 永岡 隆

  電子情報通信学会医用画像研究会  2020/11
• One-class SVMによる画素悪性度の集中性を用いたFDG-PET/CT上の病変自動検出

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 牛房 和之; 山田 誉大; 花岡 宏平; 北島 一宏; 槌谷 達也; 石井 一成

  日本医用画像工学会大会予稿集  2020/09  日本医用画像工学会
  
• One-class SVMによる画素悪性度の集中性を用いたFDG-PET/CT上の病変自動検出

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 牛房 和之; 山田 誉大; 花岡 宏平; 北島 一宏; 槌谷 達也; 石井 一成

  日本医用画像工学会大会予稿集  2020/09  日本医用画像工学会
  
• (045)DP P2-11少数症例を用いた教師無し深層学習による病変検出画像特徴量の汎用的生成－胸部 CT を用いた実験的検証－  [Not invited]

  牛房和之; 根本充貴; 木村裕一; 永岡隆; 山田誉大; 田中敦子; 林直人

  第39回日本医用画像工学会大会, 山形(オンライン開催)  2020/09
• (044)DP P1-17One-class SVM による画素悪性度の集中性を用いた FDG-PET/CT 上の病変自動検出  [Not invited]

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 牛房 和之; 山田 誉大; 花岡 宏平; 北島 一宏; 槌谷 達也; 石井 一成

  第39回日本医用画像工学会大会, 山形(オンライン開催)  2020/09
• (26a)IP Automatic detection of cervical and thoracic lesions on FDG-PET/CT by organ specific one-class SVMs  [Not invited]

  A. Tanaka; M. Nemoto; H. Kaida; Y. Kimura; T. Nagaoka; T. Yamada; K. Ushifusa; K. Hanaoka; K. Kitajima; T. Tsuchitani; K. Ishii

  International Journal of Computer Assisted Radiology and Surgery  2020/06  Springer Science and Business Media LLC
  
• (043)DP PO-1-033主成分分析を用いたHSDの次元縮約  [Not invited]

  金澤 祐斗; 永岡 隆

  第59回日本生体医工学会大会, 岡山(オンライン開催)  2020/05
• (042)DP PO-1-032ハイパースペクトラルデータを用いたメラノーマの自動診断支援システムの開発  [Not invited]

  平野 銀次; 根本 充貴; 木村 裕一; 永岡 隆

  第59回日本生体医工学会大会, 岡山(オンライン開催)  2020/05
• (041)DP PO-1-031メラノーマ診断に適した画像特徴量の追加検討  [Not invited]

  田村 侑大; 根本 充貴; 木村 裕一; 永岡 隆

  第59回日本生体医工学会大会, 岡山(オンライン開催)  2020/05
• (039)DP メラノーマ自動診断支援システムの開発における単一波長画像作成方法の検討  [Not invited]

  加藤日菜; 永岡 隆

  メディカルイメージング連合フォーラム2019  2020/01
• (075)DO 正常データセットの教師なし学習に基づく病変検出支援システム画像特徴量の汎用的生成に関する検討 ～ 少規模なデータセットを用いた特徴量生成の実験的検証 ～  [Not invited]

  牛房和之; 根本充貴; 木村裕一; 永岡 隆; 山田誉大; 田中敦子; 林 直人

  メディカルイメージング連合フォーラム2019  2020/01
• (074)DO One-class SVMを用いた病変強調によるFDG-PET/CT上の頸胸部病変の自動検出  [Not invited]

  田中敦子; 根本充貴; 甲斐田勇人; 木村裕一; 永岡 隆; 山田誉大; 牛房和之; 花岡宏平; 北島一宏; 槌谷達也

  メディカルイメージング連合フォーラム2019  2020/01
• (040)DP メラノーマ診断に適した画像特徴量の検討  [Not invited]

  田村侑大; 永岡 隆

  メディカルイメージング連合フォーラム2019  2020/01
• (038)DP 認知症自動診断AIアルゴリズム学習のための深層学習によるアミロイド画像の加増手法の検討

  渡邉 綾; 山田 誉大; 永岡 隆; 根本 充貴; 花岡 宏平; 甲斐田 勇人; 石井 一成; 木村 裕一

  第59回日本核医学会学術総会  2019/11
• (035)DP Automatic Diagnosis of Melanoma Using Hyperspectral Data and GoogLeNet

  Ginji Hirano; Mitsutaka Nemoto; Yuichi Kimura; Yoshio Kiyohara; Hiroshi Koga; Naoya Yamazaki; Gustav Christensen; Atsushi Nakamura; Takayuki Sota; Takashi Nagaoka

  生体医工学シンポジウム2019  2019/09
• (036)DP Performance Improvement of Automated Melanoma Diagnosis System by Data Augmentation

  Kana Kato; Mitsutaka Nemoto; Yuichi Kimura; Yoshio Kiyohara; Hiroshi Koga; Naoya Yamazaki; Gustav Christensen; Atsushi Nakamura; Takayuki Sota; Takashi Nagaoka

  生体医工学シンポジウム2019  2019/09
• (037)DP Weighting Function for Kinetics-Based Noise Reduction in PET Amyloid Imaging

  Takahiro Yamada; Shogo Watanabe; Takashi Nagaoka; Mitsutaka Nemoto; Kohei Hanaoka; Hayato Kaida; Kazunari Ishii; Yuichi Kimura

  生体医工学シンポジウム2019  2019/09
• (034)DP 病変検出支援アルゴリズムにおける局所画像特徴量の汎用的な自動生成 -健常データのみの学習による特徴量生成の検討-  [Not invited]

  牛房 和之; 根本 充貴; 木村 裕一; 永岡 隆; 山田誉大; 林 直人

  第38回日本医用画像工学会大会  2019/07
• (073)DO ハイパースペクトラルデータを用いたメラノーマの自動診断支援システムの開発 ～ 深層学習の導入 ～  [Not invited]

  平野銀次; 永岡 隆

  電子情報通信学会医用画像研究会  2019/07
• (026)IP Automated Diagnosis of Melanoma using Three Wavelengths  [Not invited]

  Yudai Tamura; Takashi Nagaoka

  41st International Engineering in Medicine and Biology Conference  2019/07
• (025)IP Automated Melanoma Diagnosis using Transfer Learning  [Not invited]

  Kana Kato; Takashi Nagaoka

  41st International Engineering in Medicine and Biology Conference  2019/07
• (024)IP Automatic Diagnosis of Melanoma using Machine Learning  [Not invited]

  Hirano Ginji; Nagaoka Takashi

  41st International Engineering in Medicine and Biology Conference  2019/07
• (023)IP AI-Based Melanoma Diagnosis Support System Using a Hyperspectral Imaging Technique  [Not invited]

  Takashi Nagaoka

  41st International Engineering in Medicine and Biology Conference  2019/07
• (022)IP Custering-based data reduction algorithm with simplified reference tissue modelto generate parametric images in amyloid imaging

  T.Yamada; Y. Kimura; M. Sakata; T. Nagaoka; M. Nemoto; K. Hanaoka; H. Kaida; K. Ishii

  2019/07
• (032)DP FDG‐PET/CTの統計的異常検知処理による転移を考慮した頸胸部病変の自動検出  [Not invited]

  田中敦子; 根本充貴; 甲斐田勇人; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 石井一成

  日本生体医工学会大会プログラム・抄録集(Web)  2019/06
• (033)DP 深層畳み込みオートエンコーダを用いた健常データの教師なし学習による病変認識特徴量の汎用的自動生成  [Not invited]

  牛房和之; 根本充貴; 木村裕一; 永岡隆; 山田誉大; 林直人

  日本生体医工学会大会プログラム・抄録集(Web)  2019/06
• (072)DO 皮膚のスペクトル解析とその応用  [Not invited]

  永岡隆

  日本生体医工学会大会プログラム・抄録集(Web)  2019/06
• (071)DO メラノーマ診断支援装置ハイパースペクトル・イメージャー(HSI)の性能 白人色素性病変の診断能力  [Not invited]

  永岡 隆; グスタフクリステンセン; クリスチャンインバー; 清原 祥夫; 中村 厚; 宗田 孝之

  日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2019/05
• (031)DP HSDを用いたメラノーマの自動診断支援システムの開発 ～ Adaptive boostingによる鑑別 ～  [Not invited]

  平野銀次; 永岡 隆

  メディカルイメージング連合フォーラム  2019/01
• (070)DO 空間分解能を温存したノイズ低減アルゴリズムを用いたアミロイドイメージング動態撮像の短時間化  [Not invited]

  山田 誉大; 木村 裕一; 北西 巧; 永岡 隆; 根本 充貴; 花岡 宏平; 甲斐田 勇人; 石井 一成

  第8回核医学画像解析研究会, 秋田  2018/12
• (069)DO SRTM法を用いたアミロイドイメージングに対する空間分解能を損なわないノイズ低減アルゴリズムの検討  [Not invited]

  山田 誉大; 木村 裕一; 根本 充貴; 坂田 宗之; 永岡 隆; 花岡 宏平; 甲斐田 勇人; 石井 一成

  核医学  2018/11
• (067)DO メラノーマ診断支援装置ハイパースペクトル・イメージャ(HSI)の性能  [Not invited]

  中村 厚; 清原 祥夫; 古賀 弘志; 高橋 聡; 永岡 隆; 山崎 直也; 斎田 俊明; 宗田 孝之

  日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2018/07
• (068)DO ハイパースペクトルデータ(HSD)に基づく悪性黒色腫の腫瘍境界部の観察  [Not invited]

  清原 祥夫; 野口 遼介; 中村 厚; 永岡 隆; 吉川 周佐; 大塚 正樹; 杉原 悟; 宗田 孝之

  日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2018/07
• (021)IP Automatic diagnosis of melanoma using machine learning  [Not invited]

  G. Hirano; T. Nagaoka

  World Congress on Medical Physics and Biomedical Engineering  2018/06
• (030)DP PETアミロイドイメージングのための空間分解能を損なわないノイズ低減アルゴリズムの臨床画像による評価  [Not invited]

  山田誉大; 木村裕一; 藤井康介; 渡辺翔吾; 永岡隆; 根本充貴; 花岡宏平; 甲斐田勇人; 石井一成; 石井一成

  日本生体医工学会大会プログラム・抄録集(Web)  2018/06
• (020)IP Noise Reduction Algorithm for Amyloid Imaging to Preserve the Contrast Between Gray and White Matters Using Simplified Reference Tissue Model

  T Yamada; Y Kimura; K Fujii; S Watanabe; T Nagaoka; M Nemoto; K Hanaoka; C Hosokawa; K Ishii

  World Congress of the World Federation of Nuclear Medicine and Biology  2018/04
• (029)DP HSDを用いたメラノーマの自動診断支援システムの開発 ～ 機械学習による鑑別 ～  [Not invited]

  竹村香音; 平野銀次; 永岡 隆

  メディカルイメージング連合フォーラム  2018/03
• (019)IP Noise Reduction Algorithm for Amyloid Image Preserving Image Resolution. - Quantitative Evaluation Using Clinical Images -  [Not invited]

  T.Yamada; Y.Kimura; K.Fuji; S.Watanabe; T.Nagaoka; M.Nemoto; K.Hanaoka; H.Kaida; C.Hosokawa; K.Ishii

  Human Amyloid Imaging Conference  2018/01
• (066)DO 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価  [Not invited]

  山田 誉大; 木村 裕一; 藤井 康介; 渡辺 翔吾; 永岡 隆; 花岡 宏平; 細川 知紗; 石井 一成; 村上 卓道

  第57回日本核医学会学術総会  2017/10
• (028)DP ハイパースペクトラルイメージャーを用いた化粧品の定量評価に関する基礎研究  [Not invited]

  永岡隆; 麻生祐未; 横山真由; 河本敬子

  Aesthetic Dermatology  2017/07
• (065)DO PETアミロイドイメージングによる参照領域自動設定アルゴリズムの開発 - 時間情報及びクラスタ数の再検討 -  [Not invited]

  山田 誉大; 木村 裕一; 永岡 隆; 花岡 宏平; 細川 知紗; 石井 一成

  第56回日本生体医工学会大会  2017/05
• (064)DO サマースクールの目指すもの  [Not invited]

  永岡 隆

  第56回日本生体医工学会大会  2017/05
• Development of automated delineation algorithm of reference regions for amyloid imaging. - Considering time information and the number of clusters -

  Yamada Takahiro; Kimura Yuichi; Nagaoka Takashi; Hanaoka Kohei; Hosokawa Chisa; Ishii Kazunari

  Transactions of Japanese Society for Medical and Biological Engineering  2017  Japanese Society for Medical and Biological Engineering
   

  In Alzheimer's disease (AD) amyloid-β (Aβ) depositions disturbs neurons irreversibly, and early treatment before occurrence of dementia is important for AD treatments. This study aims at proposing an automated delineation algorithm for reference regions (AutoRef) for Aβ accumulation quantification. This presentation focuses on merits of a limited temporal information and the increased number clusters. As a result, for 86 clinical data (43 cases of AD, 33 cases of normal and 10 cases of equivocal deposition of Aβ), AutoRef succeeded in delineating the reference region for all the data. There was no significant difference (p < 0.05) between AutoRef and manually delineated reference region by a physician. The standard deviation of the difference between them was smaller than the discrimination threshold of AD used in actual clinical practice. In conclusions, the effectiveness of this study was suggested.

• (018)IP Algorithm for reference region delineation for amyloid imaging using pattern recognition scheme and kinetics of administered Aβ probe ― considering the number of clusters ―  [Not invited]

  T. Yamada; Y. Kimura; T. Nagaoka; C. Hosokawa; T. Murakami; K. Ishii

  Human Amyloid Imaging Conference  2017/01
• (017)IP Investigation of Potential Usability of Machine Learning to Diagnosis of Parkinson Disease Using SPECT DaTSCAN  [Not invited]

  S. Watanabe; T. Nagaoka; Y. Kimura

  International Forum on Medical Imaging in Asia (IFMIA2017)  2017/01
• (016)IP Performance Evaluation of Kinetics-Based Denoising Algorithm for PET Amyloid Imaging  [Not invited]

  K. Fuji; T. Yamada; T. Nagaoka; Y. Kimura

  International Forum on Medical Imaging in Asia (IFMIA2017)  2017/01
• (026)DP 化粧品のもちの定量評価―ファンデーションの時間変化―  [Not invited]

  藤本茜; 永岡隆

  電子情報通信学会技術研究報告  2017/01
• (025)DP メラノーマの診断支援システムの開発―病変部の面積が及ぼす影響―  [Not invited]

  平野銀次; 永岡隆

  電子情報通信学会技術研究報告  2017/01
• (027)DP 化粧品の主観評価とスペクトルの相関  [Not invited]

  舩倉美咲; 永岡隆

  電子情報通信学会技術研究報告  2017/01
• (024)DP 陽電子断層画像・アミロイドイメージングによるアルツハイマー病早期診断のためのデータ処理法  [Not invited]

  木村 裕一; 山田 誉大; 永岡 隆

  第17回計測自動制御学会 システムインテグレーション部門講演会(SI2016)  2016/12
• (023)DP 臨床データを用いたPETアミロイドイメージングにおける 参照領域自動設定法の性能評価  [Not invited]

  山田 誉大; 木村 裕一; 永岡 隆; 岡田 志麻; 細川 知紗; 石井 一成

  生体医工学シンポジウム2016  2016/09
• (022)DP PETアミロイドメージングにおけるトレーサの動態に基づいたノイズ除去アルゴリズムの可用性検討  [Not invited]

  藤井康介; 木村裕一; 山田誉大; 坂田宗之; 永岡 隆; 細川知紗; 石井一成

  生体医工学シンポジウム2016  2016/09
• (015)IP Hyperspectroscopic Evaluation correlated to the Subjective Evaluation for Cosmetics  [Not invited]

  NAGAOKA Takashi

  38th Annual International Conference of the IEEE EMBS  2016/08
• (003)IO Deliniation Algorithm on Reference Region for Amyloid Imaging Using a Time History of Radioactivity  [Not invited]

  Y. Kimura; T. Yamada; C. Hosokawa; S. Okada; T. Nagaoka; K. Ishii

  SNMMI 20016 Annual Meeting, San Diego, USA  2016/06
• (062)DO メラノーマ診断支援装置ハイパースペクトル・イメージャーの性能~掌蹠の色素性病変~:第五報  [Not invited]

  朴木達也; 高橋聡; 古賀弘志; 清原祥夫; 片桐孝太; 中村厚; 永岡隆; 山崎直也; 斎田俊明; 宗田孝之

  日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2016/05
• (063)DO メラノーマ診断支援装置ハイパースペクトル・イメージャーの性能~腫瘍厚の推定~:第六報  [Not invited]

  清原祥夫; 永岡隆; 中村厚; 古賀弘志; 斎田俊明; 宗田孝之

  日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2016/05
• (021)DP 肺癌患者における呼気ガス中揮発性有機化合物測定の有用性の検討  [Not invited]

  小熊剛; 永岡隆; 小林尚史; 倉橋宗重; 滝口寛人; 友松克允; 友松裕美; 新美京子; 端山直樹; 青木琢也; 浦野哲哉; 阿部直; 浅野浩一郎

  日本呼吸器学会誌  2016/04
• (061)DO Application of hyperspectral imaging in medicine  [Not invited]

  永岡 隆

  生体医用画像研究会第3回若手発表会  2016/03
• Validation of automated delineation algorithm of reference regions in PET amyloid imaging based on kinetics of administered amyloid probe

  Yamada Takahiro; Kimura Yuichi; Nagaoka Takashi; Okada Shima; Hosokawa Chisa; Ishii Kazunari

  Transactions of Japanese Society for Medical and Biological Engineering  2016  Japanese Society for Medical and Biological Engineering
   

  A deposit of amyloid β (Aβ) to the central nervous system causes Alzheimer's disease (AD). A periodical evaluation on Aβ, a year, can therefor detect the beginning of AD, and it realizes an effective medical treatment for AD. For quantitative measurement of Aβ deposit is available using PET, and it requires to delineate the cerebellum gray matter as a reference region, when no Aβ deposit occurs physiologically and it has complicated shape. This study aim at proposing automated delineation algorithm based on a kinetics of administered PET tracer for Aβ imaging. The validation using a clinical data presented no significant difference (p < 0.05) between the amount of Aβ deposit using an ordinary manual delineation and the automated method. We can conclude that the algorithm is clinically useful.

• (060)DO Algorithm for automated delineation of reference regions in PET amyloid imaging based on pattern recognition scheme and kinetics of administered tracer-Performance evaluation using climical data-  [Not invited]

  山田誉大; 木村裕一; 永岡隆; 岡田志麻; 細川知紗; 石井一成

  電子情報通信学会技術研究報告  2016/01
• (002)D講演 ハイパースペクトラルイメージャーを用いたメラノーマ診断支援システムの開発  [Invited]

  永岡 隆

  レーザー学会学術講演会第36回年次大会  2016/01
• (058)DO Algorithm for automated delineation of reference regions in PET amyloid imaging based on pattern recognition scheme and kinetics of administered tracer  [Not invited]

  山田誉大; 木村裕一; 永岡隆; 岡田志麻; 細川知紗; 石井一成

  電子情報通信学会技術研究報告  2015/11
• (059)DO アミロイドイメージングにおける組織放射能時間曲線に対するパターン認識による参照領域設定アルゴリズム  [Not invited]

  木村裕一; 山田誉大; 永岡 隆; 細川知紗; 石井一成; 村上卓道

  第55回日本核医学会学術総会  2015/11
• (020)DP PETアミロイドイメージングにおける参照領域自動設定アルゴリズムの開発  [Not invited]

  山田 誉大; 木村 裕一; 永岡 隆; 岡田 志麻; 細川 知紗; 石井 一成

  日本生体医工学会シンポジウム2015  2015/09
• (014)IP Fiber-type hyperspectral melanoma screening system  [Not invited]

  Nagaoka T; Nakamura A; Kiyohara Y; Sota T

  37th annual international conference of the IEEE Engineering in Medicine and Biology Society  2015/08
• (001)D講演 宇宙からの目で皮膚を診る  [Invited]

  永岡 隆

  第7回バイオメクフォーラム21, 大阪大学  2015/07
• (057)DO メラノーマ診断支援装置ハイパースペクトラル・イメージャーの性能:第四報  [Not invited]

  片桐孝太; 永岡 隆; 中村 厚; Gustav Christensen; Christian Ingvar; 古賀弘志; 清原祥夫; 斎田俊明; 宗田孝之

  第31回日本皮膚悪性腫瘍学会学術大会  2015/07
• (056)DO ハイパースペクトルイメージャを用いたメラノーマの自動診断−第5報−  [Not invited]

  永岡 隆; 中村 厚; 清原祥夫; 宗田孝之

  第15回計測自動制御学会 システムインテグレーション部門講演会(SI2014)  2014/12
• (018)DP 経日に伴う潜在指紋成分の蛍光強度の増減  [Not invited]

  HIBINO KAZUTO; NAKAMURA ATSUSHI; NAGAOKA TAKASHI; TAKEUCHI SHIGEKI; SHIMODA OSAMU; TAKATSU MASAHISA; AKIBA NORIMITSU; KUROSAWA KENJI; KUROKI KENRO; SOTA TAKAYUKI

  日本法科学技術学会誌  2014/10
• (019)DP 近赤外カメラによる潜在指掌紋の顕在化~冷媒HFC152aによる前処理の効果~  [Not invited]

  NAKATSUKASA TAKUYA; SHIMODA OSAMU; SAWADA YUJI; KIMURA KOJI; KAMITA TOMOKAZU; MIURA YOSHIMASA; OGUSHI MASANORI; SAKATA MASAMICHI; TAKATSU MASAHISA; TAKEUCHI SHIGEKI; HIBINO KAZUTO; AKIBA NORIMITSU; KUROSAWA KENJI; KUROKI KENRO; NAKAMURA ATSUSHI; NAGAOKA TAKASHI; SOTA TAKAYUKI

  日本法科学技術学会誌  2014/10
• (013)IP Possible spectral separation of overlapped fingerprints  [Not invited]

  Takashi Nagaoka; Atsushi Nakamura; Hidekazu Okuda; Norimitsu Akiba; Kenro Kuroki; Kenji Kurosawa; Fumihiko Ichikawa; Akira Torao; Takayuki Sota

  22nd International Symposium on the Forensic Sciences of the Australian and New Zealand Forensic Science Society  2014/09
• (054)DO ヒト呼気に含まれる揮発性有機化合物測定システムを用いた日内変動の測定  [Not invited]

  KANO SAKI; NAGAOKA TAKASHI; KOBAYASHI NAOFUMI; KURAHASHI MUNESHIGE; TAKEDA SUNAO; AOKI TAKUYA; TSUJI CHIZUKO; URANO TETSUYA; ABE TADASHI; MAGATANI KAZUSHIGE

  日本生体医工学会大会プログラム・論文集(CD-ROM)  2014/06
• (055)DO メラノーマ診断支援装置ハイパースペクトラル・イメージャーの性能:第三報  [Not invited]

  AOKI TOSHIYUKI; AKIYAMA SAORI; NAGAOKA TAKASHI; NAKAMURA ATSUSHI; KOGA HIROSHI; KIYOHARA YOSHIO; SAIDA TOSHIAKI; SOTA TAKAYUKI

  日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2014/06
• 3A1-E04 Basic research towards development of an expiration gas analysis system(Medical Robotics and Mechatronics (1))

  PANYASIRI Pongsakorn; KANO Saki; NAGAOKA Takashi; KOBAYASHI Naofumi; KURAHASHI Muneshige; TAKEDA Sunao; AOKI Takuya; TSUJI Tizuko; Urano Tetsuya; ABE Tadashi; MAGATANI Kazushige

  ロボティクス・メカトロニクス講演会講演概要集  2014/05  The Japan Society of Mechanical Engineers
   

  In the purpose of pathological state by exhalation, we have developed an expiration gas analysis system. Also now there are various problems when subjects use the equipment for collecting breath gas. So we have developed the new equipment for collecting breath gas that using a pressure sensor to improve the ability to collect the sample. And because we want to know the difference between breathing resistance of the new equipment for collecting breath gas and currently equipment for collecting breath gas. So we have a subject to use the equipment of both. And we examined the breathing resistance at that time.
• (012)IP Sleep-Apnea-Related Volatile Organic Compounds Are Elevated In Severe Obstructive Sleep Apnea Patients  [Not invited]

  T. Aoki; T. Nagaoka; N. Kobayashi; M. Kurahashi; S. Yamamori; C. Tsuji; J. Tanaka; M. Sato; Y. Horio; H. Takiguchi; H. Tomomatsu; K. Tomomatsu; K. Niimi; N. Hayama; T. Oguma; T. Urano; K. Magatani; S. Takeda; K. Asano; T. Abe

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE  2014/05  AMER THORACIC SOC
  
• (017)DP ハイパースペクトラルイメーシングを用いた肌色計測による化粧品効果の評価  [Not invited]

  TOTSUKA HIRONO; NAGAOKA TAKASHI; SOTA TAKAYUKI; KIN GINSHUKU; HANAYA TSUGUO; YAMAMOTO SAWAKO; BERUMAN DAMIAN; BATISU DOMINIKU; AJURU KURISUTOFU

  日本皮膚科学会雑誌  2014/04
• (011)IP Hyperspectral Imaging of Latent Fingerprints and/or Palm Prints  [Not invited]

  T. Nagaoka; A. Nakamura; H. Okuda; N. Akiba; K. Kuroki; K. Kurosawa; F. Ichikawa; A. Torao; T. Sota

  66th Annual Meeting of the AAFS, Seatle, USA  2014/02
• (010)IP System improvements for exhaled breath measurement system  [Not invited]

  S. Kanou; S. Iitsuka; T. Nagaoka; N. Kobayashi; M. Kurahashi; S. Takeda; T. Aoki; C. Tsuji; T. Urano; T. Abe; K. Magatani

  IFMBE Proceedings  2014/01 

  © Springer International Publishing Switzerland 2014. As many as 200 kinds of volatile organic compounds (VOCs) are included in human exhaled breath. Many papers using VOCs as a biomarker of respiratory diseases have been reported. However, it is very difficult to measure very low concentration of VOCs in exhaled breath with high precision. Moreover, it is also difficult to distinguish VOCs in exhaled breath and VOCs in atmosphere. Therefore, measurement of VOCs is rarely used in a clinical field because complicated and large-sized system is required for measure VOCs in exhaled breath. We are developing exhaled breath measurement system which overcame these problems. Our system analyzes exhaled breath discharged from living body by inhaling atmosphere from which VOCs were removed. In this paper, results of system improvements are reported. At first, we adopted a cold trap method with dry ice as a method of purifying atmosphere (method A). Method A needs complicated device and long processing time. Next, we changed the method into solid absorbent from method A (method B). We verified purity of purified air. Concentration of 10 kinds of VOCs contained in both exhaled breath and atmosphere were measured. Selected VOCs are as follows: benzene, cyclohexane, ethylbenzene, heptanes, hexane, isoprene, nonane, octane, toluene and xylene. Atmosphere was purified by the method A and B. Concentrations of VOCs contained in the purified air were measured by gas chromatography. As a result of measurement, almost VOCs were not detected in the purified air made by both methods. Furthermore, time to make purified air was reduced from 70 minutes to 10 minutes. Simplification of the system and shorter processing time than method A were realized by method B while keeping purity.
• (053)DO 呼気ガス分析システムの開発に向けた基礎研究  [Not invited]

  狩野早紀; 永岡 隆; 小林尚史; 倉橋宗重; 武田朴; 小熊剛; 辻千鶴子; 青木琢也; 浦野哲哉; 浅野浩一郎; 阿部 直; 曲谷一成

  第14回計測自動制御学会 システムインテグレーション部門講演会(SI2013)  2013/12
• (016)DP 高出力グリーンレーザによる潜在指掌紋の顕在化(第3報)~潜在指紋成分の蛍光とバックグラウンド蛍光との関係~  [Not invited]

  HIBINO KAZUTO; TAKEUCHI SHIGEKI; SHIMODA OSAMU; TAKATSU MASAHISA; AKIBA NORIMITSU; KUROSAWA KENJI; KUROKI KENRO; NAKAMURA ATSUSHI; NAGAOKA TAKASHI; SOTA TAKAYUKI

  日本法科学技術学会誌  2013/10
• (052)DO メラノーマ診断支援装置ハイパースペクトラル・イメージャーの性能:第二報  [Not invited]

  AKIYAMA SAORI; KIYOHARA YOSHIO; KOGA HIROSHI; YAMAGUCHI ASATO; NAGAOKA TAKASHI; NAKAMURA ATSUSHI; SAIDA TOSHIAKI; SOTA TAKAYUKI

  日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2013/08
• (009)IP Hyperspectroscopic screening of melanoma  [Not invited]

  T. Nagaoka; A. Nakamura; Y. Kiyohara; H. Koga; T. Saida; T. Sota

  8th World Congress of Melanoma, Hamburg, Germany  2013/07
• (051)DO 睡眠時無呼吸症候群患者における呼気中の揮発性有機化合物濃度の検討  [Not invited]

  AOKI TAKUYA; NAGAOKA TAKASHI; KURAHASHI MUNESHIGE; KOBAYASHI HISASHI; YAMAMORI SHINJI; IIZUKA SHINJIRO; TAKIGUCHI HIROTO; TOMOMATSU HIROMI; TOMOMATSU KATSUIN; NIIMI KYOKO; HAYAMA NAOKI; OGUMA TSUYOSHI; URANO TETSUYA; TSUJI CHIZUKO; TAKEDA SUNAO; MAGATANI KAZUSHIGE; ASANO KOICHIRO; ABE TADASHI

  呼吸  2013/05
• (049)DO 肺癌患者における呼気ガス中の揮発性有機化合物の検討  [Not invited]

  OGUMA TAKESHI; ASANO KOICHIRO; NAGAOKA TAKASHI; KOBAYASHI HISASHI; TAKIGUCHI HIROTO; TOMOMATSU KATSUYOSHI; TOMOMATSU YUMI; NIIMI KYOKO; HAYAMA NAOKI; AOKI TAKUYA; URANO TETSUYA; ABE TADASHI

  日本呼吸器学会誌  2013/03
• (050)DO 睡眠時無呼吸症候群における無呼吸低呼吸指数と呼気中の揮発性有機化合物の関連  [Not invited]

  AOKI TAKUYA; NAGAOKA TAKASHI; KURAHASHI MUNESHIGE; KOBAYASHI HISASHI; YAMAMORI SHINJI; IIZUKA SHINJIRO; TAKIGUCHI HIROTO; TOMOMATSU YUMI; TOMOMATSU KATSUYOSHI; NIIMI KYOKO; HAYAMA NAOKI; OGUMA TSUYOSHI; URANO TETSUYA; TSUJI CHIZUKO; TAKEDA SUNAO; MAGATANI KAZUSHIGE; ASANO KOICHIRO; ABE TADASHI

  日本呼吸器学会誌  2013/03
• (048)DO ハイパースペクトルイメージャを用いたメラノーマの自動診断−第4報−  [Not invited]

  永岡 隆; 中村 厚; 山口麻人; 秋山彩織; 清原祥夫; 宗田孝之

  第13回計測自動制御学会 システムインテグレーション部門講演会(SI2012)  2012/12
• (015)DP 喫煙習慣による呼気ガスの揮発性有機化合物の変化  [Not invited]

  IITSUKA SHINJIRO; NAGAOKA TAKASHI; KOBAYASHI NAOFUMI; KURAHASHI MUNESHIGE; TAKEDA SUNAO; AOKI TAKUYA; TSUJI CHIZUKO; URANO TETSUYA; ABE TADASHI; MAGATANI KAZUSHIGE

  日本生体医工学会大会プログラム・論文集(CD-ROM)  2012/05
• (008)IP Subclinical extension of morphea-like basal cell carcinoma: hyperspectral evaluation  [Not invited]

  T. Nagaoka; Y. Kiyohara; A. Nakamura; A. Yamaguchi; T. Sota

  Dermatol Pract Concept., Brisbane, Australia  2012/04
• (047)DO 睡眠時無呼吸症候群患者における呼気中の揮発性有機化合物の検討  [Not invited]

  AOKI TAKUYA; NAGAOKA TAKASHI; KOBAYASHI HISASHI; KURAHASHI MUNESHIGE; YAMAMORI SHINJI; IIZUKA SHINJIRO; KATO SAKURAKO; HAYAMA NAOKI; URANO TETSUYA; TSUJI CHIZUKO; TAKEDA SUNAO; MAGATANI KAZUSHIGE; ABE TADASHI

  日本呼吸器学会誌  2012/03
• (046)DO ハイパースペクトルイメージャを用いたメラノーマの自動診断−第3報−  [Not invited]

  永岡 隆; 中村 厚; 山口麻人; 清原祥夫; 宗田孝之

  第12回計測自動制御学会 システムインテグレーション部門講演会(SI2011)  2011/12
• (045)DO 足底に発生したメラノーマの自動鑑別  [Not invited]

  永岡 隆; 中村 厚; 奥谷 悠; 清原祥夫; 古賀弘志; 斎田俊明; 宗田孝之

  第27回日本皮膚悪性腫瘍学会学術大会  2011/06
• (044)DO 呼気ガス中の極微量の揮発性有機化合物(VOC:Volatile Organic Compounds)の基礎的検討  [Not invited]

  HISADA JUN'ICHIRO; AOKI TAKUYA; KOBAYASHI HISASHI; NAGAOKA TAKASHI; YAMAMORI SHINJI; INAMURA MASANORI; ISHII HIROSHI; KATO SAKURAKO; HAYAMA NAOKI; URANO TETSUYA; TAKEDA SUNAO; ABE TADASHI

  日本呼吸器学会雑誌  2011/03
• (043)DO ハイパースペクトルイメージャーを用いたメラノーマの自動診断−第2報−  [Not invited]

  永岡 隆; 中村 厚; 奥谷 悠; 清原祥夫; 宗田孝之

  第11回計測自動制御学会 システムインテグレーション部門講演会(SI2010)  2010/12
• (042)DO ハイパースペクトルデータに基づくメラノーマの新しい非侵襲的診断法の開発  [Not invited]

  奥谷 悠; 中村 厚; 永岡 隆; 清原祥夫; 宗田孝之

  第23回日本色素細胞学会学術大会  2010/11
• (040)DO メラノーマの新しい非侵襲的診断法の開発〜ハイパースペクトルデータ(HSD)に基づくメラノーマ鑑別指標〜  [Not invited]

  奥谷 悠; 永岡 隆; 中村 厚; 清原祥夫; 宗田孝之

  第26回日本皮膚悪性腫瘍学会学術大会  2010/06
• (041)DO メラノーマの新しい非侵襲的診断法の開発〜ハイパースペクトルイメージャ(HSI)によるメラノーマの診断〜  [Not invited]

  清原祥夫; 奥谷 悠; 永岡 隆; 中村 厚; 宗田孝之

  第26回日本皮膚悪性腫瘍学会学術大会  2010/06
• (007)IP A noble melanoma discrimination index based on hyperspectral data  [Not invited]

  H. Okutani; T. Nagaoka; A. Nakamura; Y. Kiyohara; T. Sota

  21st European Association for Cancer Research Congress, Oslo, Norway  2010/06
• (039)DO ハイパースペクトルカメラを用いたメラノーマの自動診断  [Not invited]

  永岡 隆; 中村 厚; 奥谷 悠; 會沢勝夫; 大坪真也; 清原祥夫; 宗田孝之

  第10回計測自動制御学会 システムインテグレーション部門講演会(SI2009)  2009/12
• (037)DO 悪性黒色腫の機械診断:可能性試験  [Not invited]

  NAGAOKA TAKASHI; NAKAMURA ATSUSHI; OKUTANI HARUKA; AIZAWA KATSUO; OTSUBO SHIN'YA; KIYOHARA YOSHIO; SOTA TAKAYUKI

  応用物理学会学術講演会講演予稿集  2009/09
• (038)DO 悪性黒色腫診断支援画像  [Not invited]

  NAKAMURA ATSUSHI; NAGAOKA TAKASHI; OTSUBO SHIN'YA; AIZAWA KATSUO; KIYOHARA YOSHIO; SOTA TAKAYUKI

  応用物理学会学術講演会講演予稿集  2009/09
• (006)IP Optical Diagnostics System of Melanoma based on Hyperspectral Imaging Technique  [Not invited]

  A. Nakamura; T. Nagaoka; S. Ohtsubo; K. Aizawa; Y. Kiyohara; T. Sota

  7th World Congress on Melanoma, Vienna, Austria  2009/05
• (005)IP Melanoma Discrimination Index derived from Optical Spectra  [Not invited]

  T. Nagaoka; A. Nakamura; K. Aizawa; S. Ohtsubo; Y. Kiyohara; T. Sota

  7th World Congress on Melanoma, Vienna, Austria  2009/05
• (014)DP ハイパースペクトルカメラを用いた悪性黒色腫の自動診断  [Not invited]

  NAGAOKA TAKASHI; NAKAMURA ATSUSHI; AIZAWA KATSUO; OTSUBO SHIN'YA; MOCHIZUKI TOORU; KIYOHARA YOSHIO; SOTA TAKAYUKI

  日本生体医工学会大会プログラム・論文集(CD-ROM)  2009/04
• (036)DO 色素性病変診断のためのメラニン量分布画像  [Not invited]

  NAKAMURA ATSUSHI; NOMURA MASAHIRO; SUZUKI ASAYOSHI; OSATO NAO; MATSUMURA AZUSA; OTSUBO SHIN'YA; AIZAWA KATSUO; SOTA TAKAYUKI; NAGAOKA TAKASHI; FURUKAWA MASAYO; KIYOHARA YOSHIO; ITO SHOSUKE; WAKAMATSU KAZUMASA

  日本皮膚科学会雑誌  2009/04
• (035)DO 色素性病変診断に向けたメラニン,ヘモグロビン濃度強調マップの作製  [Not invited]

  NAKAMURA ATSUSHI; NAGAOKA TAKASHI; OTSUBO SHIN'YA; AIZAWA KATSUO; KIYOHARA YOSHIO; SOTA TAKAYUKI

  日本皮膚科学会雑誌  2009/03
• (001)I講演 Automated Melanoma Recognition using Hyperspectral Image Analysis  [Invited]

  T. Nagaoka

  International Workshop HITS 2009, Tokyo Institute of Technology, Tokyo, Japan  2009/02
• (034)DO 多層モデルによる皮膚の分光特性推定  [Not invited]

  永岡 隆; 清原祥夫; 中村 厚; 野村将大; 鈴木麻悌; 大里奈央; 松村あずさ; 大坪真也; 會沢勝夫; 宗田孝之; 古川雅代; 伊藤祥輔; 若松一雅

  第9回計測自動制御学会システムインテグレーション部門講演会(SI2008)  2008/12
• (033)DO 3次元皮膚モデルを用いたメラニン濃度分布の画像化  [Not invited]

  NAKAMURA ATSUSHI; NAGAOKA TAKASHI; FURUKAWA MASAYO; NOMURA MASAHIRO; SUZUKI ASAYOSHI; OSATO NAO; MATSUMURA AZUSA; OTSUBO SHIN'YA; AIZAWA KATSUO; KIYOHARA YOSHIO; ITO SHOSUKE; WAKAMATSU KAZUMASA; SOTA TAKAYUKI

  応用物理学会学術講演会講演予稿集  2008/09
• (032)DO 3次元皮膚モデルの光学的特性  [Not invited]

  NAGAOKA TAKASHI; NAKAMURA ATSUSHI; FURUKAWA MASAYO; NOMURA MASAHIRO; SUZUKI ASAYOSHI; OSATO NAO; MATSUMURA AZUSA; OTSUBO SHIN'YA; AIZAWA KATSUO; KIYOHARA YOSHIO; ITO SHOSUKE; WAKAMATSU KAZUMASA; SOTA TAKAYUKI

  応用物理学会学術講演会講演予稿集  2008/09
• (013)DP 近赤外眼底分光画像に関するリング状照明モデルによる輝度値補正  [Not invited]

  NAKAMURA ATSUSHI; NAGAOKA TAKASHI; NOMURA MASAHIRO; OTSUBO SHIN'YA; AIZAWA KATSUO; SOTA TAKAYUKI

  日本生体医工学会大会プログラム・論文集(CD-ROM)  2008/05
• (011)DP 眼底スペクトル画像に対するリング照明に起因した照明ムラの除去  [Not invited]

  NAGAOKA TAKASHI; NAKAMURA ATSUSHI; SOTA TAKAYUKI; AIZAWA KATSUO; OTSUBO SHIN'YA

  日本糖尿病眼学会誌  2008/04
• (012)DP 近赤外光を用いた眼底スペクトル撮像装置の開発  [Not invited]

  NAKAMURA ATSUSHI; NAGAOKA TAKASHI; SOTA TAKAYUKI; AIZAWA KATSUO; ICHIKAWA FUMIHIKO; KANAZAWA MASAO; KEZUKA TAKESHI; SHIRAI MASAHIKO

  日本糖尿病眼学会誌  2008/04
• (031)DO ハイパースペクトルカメラを用いた皮膚血行動態の観察  [Not invited]

  永岡 隆; 清原?夫; 中村 厚; 會沢勝夫; 大坪真也; 宗田孝之; 市川文彦; 山嵜登志夫; 土居正雄; 中村勝重

  第8回システムインテグレーション部門講演会(SI2007)  2007/12
• (030)DO in vitro皮膚組織モデルを用いた分光学的メラニン色素濃度定量法の検討  [Not invited]

  NAKAMURA ATSUSHI; TANIGAWA SAYAKA; FURUKAWA MASAYO; AIZAWA KATSUO; NAGAOKA TAKASHI; OTSUBO SHIN'YA; WAKAMATSU KAZUMASA; ITO SHOSUKE; SOTA TAKAYUKI

  応用物理学会学術講演会講演予稿集  2007/09
• (004)IP Application of decorrelation stretching method to hyperspectral fundus image processing  [Not invited]

  T. Nagaoka; A. Nakamura; K. Aizawa; M. Kanazawa; T. Kezuka; M. Miura; M. Usui; S. Ohtsubo; T. Sota

  Progress in Biomedical Optics and Imaging - Proceedings of SPIE  2007/08 

  We have developed a near-infrared hyperspectral imaging system that can acquire both spectral and spatial data covering a 50-degree field at the fundus surface within 5 seconds. Single wavelength band reflectance images with bandwidth of 20 nm have demonstrated that choroidal vascular patterns can be clearly observed as bright images for the central wavelength ranging from 740 to 860 nm, while retinal blood vessels are seen as dark images for that ranging from 740 to 920 nm. It is desirable for clinical use to separate the choroidal vascular patterns image from the retinal blood vessels image. To this end, we have applied the decorrelation stretch to processing of spectral images. We have found the following. Original fundus spectral images have stripes noise. The decorrelation stretch emphasizes the noise and, thus, the noise has to be removed by, for example, DCT (Discrete Cosine Transform) filter beforehand. The choroidal vascular image can be successfully separated from the retinal vascular image. Furthermore, the macular is superimposed on the latter as it should be so from the viewpoint of anatomy. The result suggests that useful information may be extracted by combining hyperspectral images with the decorrelation stretch.
• (003)IP Near-infrared hyperspectral images of human ocular fundus and their processing with decorrelation stretch  [Not invited]

  T. Nagaoka; A. Nakamura; K. Aizawa; M. Kanazawa; T. Kezuka; M. Miura; M. Usui; S. Ohtsubo; T. Sota

  Progress in 2007 ARVO Annual Meeting "The Aging Eye", Florida, USA  2007/05
• (010)DP ハイパースペクトル医用画像を用いたerythema indicesの観察  [Not invited]

  NAGAOKA TAKASHI; NAKAMURA ATSUSHI; AIZAWA KATSUO; OTSUBO SHIN'YA; KIYOHARA YOSHIO; SOTA TAKAYUKI

  日本生体医工学会大会プログラム・論文集(CD-ROM)  2007/04
• (009)DP ハイパースペクトル眼底画像への非相関強調の適用  [Not invited]

  NAGAOKA TAKASHI; NAKAMURA ATSUSHI; AIZAWA KATSUO; KANAZAWA MASAO; KEZUKA TAKESHI; MIURA MASAHIRO; USUI MASAHIKO; OTSUBO SHIN'YA; SOTA TAKAYUKI

  日本分光学会講演要旨集  2006/11
• (008)DP 近赤外眼底ハイパースペクトル画像撮像装置の開発  [Not invited]

  NAKAMURA ATSUSHI; AIZAWA KATSUO; NAGAOKA TAKASHI; ICHIKAWA FUMIHIKO; KANAZAWA MASAO; KEZUKA TAKESHI; MIURA MASAHIRO; USUI MASAHIKO; SOTA TAKAYUKI

  日本分光学会講演要旨集  2006/11
• (029)DO 近赤外眼底スペクトル画像撮像装置の臨床応用に向けた検討  [Not invited]

  TANGO MANABU; NAKAMURA ATSUSHI; AIZAWA KATSUO; NAGAOKA TAKASHI; KANAZAWA MASAO; KEZUKA TSUYOSHI; MIURA MASAHIRO; USUI MASAHIKO; ICHIKAWA FUMIHIKO; MUNETA TAKAYUKI

  日本レーザー医学会誌  2006/07
• (003)DP 眼底スペクトル画像上でのニュートン法を用いた照明ムラ補正  [Not invited]

  KUROIWA YOHEI; NAGAOKA TAKASHI; NAKAMURA ATSUSHI; AIZAWA KATSUO; OTSUBO SHIN'YA; SOTA TAKAYUKI

  日本生体医工学会大会プログラム・論文集  2006/05
• (004)DP 近赤外眼底スペクトル画像  [Not invited]

  NAKAMURA ATSUSHI; AIZAWA KATSUO; NAGAOKA TAKASHI; ICHIKAWA FUMIHIKO; KANAZAWA MASAO; KEZUKA TAKESHI; USUI MASAHIKO; SOTA TAKAYUKI

  日本生体医工学会大会プログラム・論文集  2006/05
• (005)DP 永久磁石を用いた3次元位置検出システムの開発(第4報)  [Not invited]

  KUWATA EIGO; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本生体医工学会大会プログラム・論文集  2006/05
• (006)DP 眼底スペクトル撮像装置を用いた糖尿病性網膜症由来浮腫の観察  [Not invited]

  TANGO MANABU; NAKAMURA ATSUSHI; AIZAWA KATSUO; NAGAOKA TAKASHI; KANAZAWA MASAO; KEZUKA TAKESHI; USUI MASAHIKO; ICHIKAWA FUMIHIKO; SOTA TAKAYUKI

  日本生体医工学会大会プログラム・論文集  2006/05
• (007)DP 多波長パルス分光法による多項目血液成分無侵襲計測器の開発  [Not invited]

  SUZAKI HIRONORI; KOBAYASHI NAOKI; NAGAOKA TAKASHI; TAKEDA SUNAO; TOGAWA TATSUO

  日本生体医工学会大会プログラム・論文集  2006/05
• (002)DP スペクトル画像を用いた脈絡膜血管観察  [Not invited]

  NAKAMURA ATSUSHI; NAGAOKA TAKASHI; SOTA TAKAYUKI; AIZAWA KATSUO; ICHIKAWA FUMIHIKO; KANAZAWA MASAO; KEZUKA TAKESHI; USUI MASAHIKO

  応用物理学関係連合講演会講演予稿集  2006/03
• (001)DP 眼底スペクトル画像における照明系に起因した輝度値変化の補正  [Not invited]

  NAGAOKA TAKASHI; NAKAMURA ATSUSHI; SOTA TAKAYUKI; AIZAWA KATSUO; OTSUBO SHIN'YA

  応用物理学関係連合講演会講演予稿集  2006/03
• (002)IP Development of 3-d position sensor by using permanent magnets in the digestive tract  [Not invited]

  T. Nagaoka; A. Uchiyama

  The 3rd European Medical and Biological Engineering Conference EMBEC'05, Prague, Czech Republic  2005/12 

  Medical capsule devices such as video capsule endoscopes are finding increasing use in clinical applications. At present, technologies capable of measuring capsule position and detecting a bleeding in the digestive tract at the same time have not yet been established. The present study aims to develop a small wireless position and bleeding detection sensor. The sensor position are measured by using the phenomenon of mutual induction and Newton's law. Electromotive forces induced in the sensor are modulated to FM signals using an astable multivibrator, and the signals are passed directly through living tissue at low current and then demodulated by detectors on the surface of the body. A prototype sensor was developed and evaluated in vitro. The sensor was capable of accurately measuring capsule position up to 500 (mm) from the primary coils with an accuracy of 5 (mm), and detecting 0.5 cc blood in 500 cc physiological saline. © 2005 IEEE.
• (028)DO C-10-4 Development and Evaluation of 3-D position sensor using a permanent magnet  [Not invited]

  Nagaoka Takashi

  Proceedings of the Society Conference of IEICE  2005/09
• (027)DO Application of 3-D position measurement sensor using permanent magnet  [Not invited]

  ICHIKAWA Daisuke; NAGAOKA Takashi; UCHIYAMA Akihiko; TAKEDA Sunao

  電気学会研究会資料. MBE, 医用・生体工学研究会  2005/07
• (026)DO 運動中の心電図計測・解析システムの開発  [Not invited]

  CHIYODA SHIGEO; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会大会論文集  2005/04
• (024)DO 透過波を利用した超音波断層像構築に向けた基礎研究  [Not invited]

  KUWATA EIGO; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会大会論文集  2005/04
• (025)DO 永久磁石を用いた位置検出システムの開発(第三報)  [Not invited]

  ICHIKAWA DAISUKE; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会大会論文集  2005/04
• (022)DO 永久磁石を用いた位置検出システムの開発(第二報)  [Not invited]

  ICHIKAWA DAISUKE; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会秋季大会論文集  2004/11
• (021)DO 無線式カプセル型三次元位置センサの開発  [Not invited]

  NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会秋季大会論文集  2004/11
• (023)DO 無侵襲Co‐Oximeterの開発  [Not invited]

  SUZAKI HIRONORI; KOBAYASHI NAOKI; KUBOTA HIROSHI; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会秋季大会論文集  2004/11
• (020)DO Development of wireless 3-D position sensor using magnetic field  [Not invited]

  NAGAOKA T; ICHIKAWA D; UCHIYAMA A

  日本応用磁気学会学術講演概要集 = Digest of ... annual conference on magnetics in Japan  2004/09
• (018)DO 非観血血圧計測における耐ノイズ性向上に関する基礎的研究  [Not invited]

  DODA HIDENORI; USUDA TAKASHI; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会大会論文集  2004/05
• (019)DO 永久磁石を用いた位置検出システムの開発  [Not invited]

  ICHIKAWA DAISUKE; NAGAOKA TAKASHI; TAKEDA SUNAO; UCHIYAMA AKIHIKO

  日本ME学会大会論文集  2004/05
• (017)DO カプセル型三次元位置センサの無線化への検討  [Not invited]

  NAGAOKA TAKASHI; UCHIYAMA AKIHIKO

  日本ME学会大会論文集  2004/05
• (001)IP Development of 3-D Position Sensor for capsule endoscopy  [Not invited]

  T. Nagaoka

  3rd International Conference on CAPSULE ENDOSCOPY, Miami, USA  2004/02
• (016)DO 生体用カプセル型三次元位置センサの開発  [Not invited]

  永岡 隆; 内山明彦

  第17回日本エム・イー学会秋季大会  2003/10
• (015)DO 有線式カプセル型三次元位置センサを用いた大腸の蠕動運動の計測  [Not invited]

  永岡 隆; 武田 朴; 松本孝嗣; 高尾良彦; 穴澤貞夫; 内山明彦

  MEシンポジウム2003  2003/08
• (002)IO Development of the three-dimensional position sensor for capsule position detection in digestive tract  [Not invited]

  T.Nagaoka; A.Uchiyama

  Conference of the International Society on Biotelemetry  2003/08
• (012)DO 消化管運動計測のためのカプセル型三次元位置センサの開発とその小型化の検討  [Not invited]

  永岡 隆; 内山明彦

  平成15年電気学会電子・情報・システム部門大会講演論文集  2003/05
• (014)DO 永久磁石を用いた生体内のカプセル位置検出システムの開発  [Not invited]

  永岡 隆; 市川大輔; 内山明彦

  第42回日本エム・イー学会大会  2003/05
• (013)DO 消化管内のカプセル位置を取得する三次元位置センサの開発  [Not invited]

  永岡 隆; 武田 朴; 松本孝嗣; 高尾良彦; 穴澤貞夫; 内山明彦

  第42回日本エム・イー学会大会  2003/05
• (011)DO 消化器官の運動や生理的現象を解析するシステムの開発 －第２報－  [Not invited]

  永岡 隆; 内山明彦

  電気学会研究会資料（医用・生体工学研究会）  2003/03
• (010)DO 消化器官の運動や生理的現象を解析するシステムの開発  [Not invited]

  永岡 隆; 長澤拓弥; 武田朴; 松本孝嗣; 高尾良彦; 穴澤貞夫; 内山明彦

  電気学会研究会資料（医用・生体工学研究会）  2002/10
• (009)DO 脛骨高位骨切り術シミュレーションのための軟組織の変形と干渉を考慮できる膝モデルの開発  [Not invited]

  永岡 隆; 川上秀夫; 米延策雄; 菅野伸彦; 萩尾圭介; 吉川秀樹; 越智隆弘; 服部麻木; 鈴木直樹

  第41回日本ME学会大会  2002/05
• (008)DO New Three-Dimensional Endoscopic Sonograph Using Electo-Magnetic Tracking System  [Not invited]

  SUMIYAMA K; SUZUKI N; HATTORI A; KOIZUMI N; NAGAOKA T; UCHIYAMA Y; IKEDA K; KAKUTANI H; TAJIRI H; AOKI T

  Journal of Japan Society of Computer Aided Surgery : J.JSCAS  2001/12
• (007)DO Assesment of A Surgical Planning for High Tibial Osteotomy using a 3D Simulation Program  [Not invited]

  KAWAKAMI Hideo; SUGANO Nobuhiko; HAGIO Keisuke; YONENOBU Kazuo; YOSHIKAWA Hideki; OCHI Takahiro; NAGAOKA Takashi; HATTORI Asaki; SUZUKI Naoki

  Journal of Japan Society of Computer Aided Surgery : J.JSCAS  2001/12
• (006)DO Development of Simulation System for High Tibia Osteotomy Using Muscle and Tendon Model  [Not invited]

  NAGAOKA T; KAWAKAMI H; YONENOBU S; SUGANO N; HAGIO K; YOSHIKAWA H; OCHI T; HATTORI A; SUZUKI N

  Journal of Japan Society of Computer Aided Surgery : J.JSCAS  2001/12
• (001)IO The Development of Diagnosis Support System using 4D Imaging and VR Environment  [Not invited]

  T.Nagaoka; N.Suzuki; A.Hattori, Richard A.Robb; K.Sumiyama; N.Koizumi; A.Uchiyama

  The 5th World Multiconference on Systemics, Cybernetics and Informatics SCI, Florida, USA  2001/08
• (004)DO 四次元画像診断支援システムの開発  [Not invited]

  永岡 隆; 鈴木直樹; 服部麻木; Richard A.Robb; 炭山和毅; 小泉直史; 内山明彦

  第40回日本ME学会大会  2001/05
• (005)DO コンベックス走査式超音波内視鏡により得た超音波三次元データセットの表示法の開発  [Not invited]

  小泉直史; 炭山和毅; 青木照明; 鈴木直樹; 服部麻木; 永岡 隆; 内山明彦

  第40回日本ME学会大会  2001/05
• (002)DO The Development of Visualization Method for Four-Dimensional Image Using VR Environment  [Not invited]

  NAGAOKA T; SUZUKI N; HATTORI A; ROBB Richard A; SUMIYAMA K; UCHIYAMA A

  Journal of Japan Society of Computer Aided Surgery : J.JSCAS  2000/12
• (003)DO New Three Dimensional Endoscopic Ultrasound Systems with Convex Scanning Echoendoscopes  [Not invited]

  SUMIYAMA K; SUZUKI N; HATTORI A; KOIZUMI N; NAGAOKA T; HINO S; SUZUKI H; AOKI T

  Journal of Japan Society of Computer Aided Surgery : J.JSCAS  2000/12
• (001)DO 四次元ＣＴデータセット可視化のための表示システムの開発  [Not invited]

  永岡 隆; 鈴木直樹; 服部麻木; 松下 聡; 高津光洋; 内山明彦

  第39回日本ME学会大会  2000/05

Works

• ハイパースペクトルイメージング技術の臨床応用

  永岡 隆 Others 2008/04 - Today 

  位置情報と波長情報を同時に取得することができるハイパースペクトルイメージング技術を利用し、無侵襲で生体の様々な情報を計測・診断するシステムの開発を推進。早稲田大学・三鷹光器・静岡がんセンター・信州大学・国立がん研究センターなどと共同研究を実施。眼科・皮膚科・消化器外科・口腔外科用途のシステムを開発した。眼科では加齢黄斑変性を検出するシステムを開発。皮膚科ではメラノーマを高い精度で鑑別するシステムを開発し、国内外における臨床試験が進められている。特にメラノーマを鑑別するアルゴリズムの開発と、装置のインターフェースの開発に従事。アルゴリズム開発ではリモートセンシング分野で使われていたSpectral Angleの技術と、エントロピーの原理を組み合わせた独自のメラノーマ鑑別指標を開発。メラノーマを90%以上の精度で鑑別することに成功している。
• マルチスペクトル眼底カメラの撮影画像に生じる照明ムラ除去法の開発とその応用

  永岡 隆 Others 2006/04 -2008/03 

  生活習慣病（成人病）の早期発見のための検査の一つとして，集団検診などで眼底画像による検査が実施されている．眼底画像は一般に眼底カメラと呼ばれる機器で撮影されることが多いが，その撮影時の照明として，リング状の照明が用いられることが多い．眼底画像を撮像するための光路を確保し，かつ十分な光量の照明を当てるためにリング照明が採用されているが，リング照明の場合，照明光が平行光とならず，被写体に対してどうしても照明ムラが発生してしまうという欠点を抱えている．当該研究課題では，この照明ムラを数学的手法により取り除き，リング照明下ながら，平行光によって照明されたような眼底画像を取得する方法の開発を推進．研究で開発したアルゴリズムを基に，コンピュータグラフィックスを用いた画像表示システムを構築し，画像本来の持つ情報を損なうことなく，照明ムラを取り除くことに成功．眼底画像全体のコントラストの向上と，暗部に隠されていた血管の走行を確認することに成功．
• 生体内三次元位置計測センサの開発とその応用

  永岡 隆 Others 2003/04 -2006/03 

  食生活の欧米化により患者数の増加が予想される消化器系の疾患に対し，臨床において試験が進められているカプセル型内視鏡であるが、その位置を正確に把握できないという問題を抱えていた。そこでカプセル型内視鏡の位置を計測できる程度のサイズ・精度を持った三次元位置計測センサの開発を東京慈恵会医科大学などとの共同研究として推進．有線式の試作機における動物実験を実施し、位置計測アルゴリズムの有用性の確認を終え，臨床応用に向けた実用化研究に着手．相互誘導起電力を応用したセンサと永久磁石を用いたセンサの2種類を開発。センサの無線化，小型化，多機能化，生体外からの姿勢制御についての技術開発を推進した．特に相互誘導起電力を用いた位置センサの開発において、双方に三軸必要であったコイルを、検出側1軸、励磁側6軸とすることで、検出精度を落とすことなく、カプセル側の電子回路を小型化することを実現。
• 脛骨高位骨切り術シミュレーションのための軟組織の変形と干渉を考慮した膝モデルの開発

  永岡 隆 Others 2001/04 -2003/03 

  高齢化社会の進展により患者数の増加が予想される、変形性膝関節症に対する外科的措置である脛骨高位骨切り術の手術シミュレーションシステムの開発を大阪大学医学部との共同研究として推進。術前に計測された患者のMRI画像からモデルを構築し、歩様推定に必要な各種座標系を自動的に設定できるシステムを構築。事前に術式、切除量をシミュレーションできるシステムを開発した。システムは実際の臨床現場に導入され、術中でもリアルタイムに各種パラメータをモデルに反映し、シミュレーションできる機能が高く評価された。
• 三次元CTの効果的な表示法の開発

  永岡 隆 Others 1999/04 -2001/03 

  新エネルギー・産業技術総合開発機構(NEDO)における「高速コーンビーム3次元X線CT」プロジェクトにて開発された、高速コーンビーム3次元X線CTを用い、三次元CTで得られたデータを効果的に表示・診断が可能なシステムの開発を推進。また、米国Mayo Clinicとの共同研究で、4次元X線CTによって計測された犬の心臓の拍動データの解析を担当。VR空間上で膨大なデータから必要なスライドのみを容易に選択できる環境を構築。形状の把握に適しているサーフェスレンダリング法と、流体の流れを可視化できるボリュームレンダリング法を組み合わせ、心臓内の血流の状態と心臓内壁の拍動状態を同時に観察できる新しいレンダリング方法を開発した。

MISC

• 生体医工学サマースクール2022実施報告

  坪子 侑佑; 木村 雄亮; 長嶋 耕平; 桑名 健太; 土井根 礼音; 前田 祐佳; 黒田 嘉宏; 永岡 隆; 荒船 龍彦  生体医工学  60-  (4-5)  126  -129  2022/09
• 生体医工学サマースクール2021実施報告

  桑名 健太; 木村 雄亮; 佐藤 裕一; 坪子 侑佑; 土井根 礼音; 前田 祐佳; 黒田 嘉宏; 永岡 隆; 西川 拓也; 朔 啓太; 荒船 龍彦  生体医工学  59-  (6)  185  -187  2021/12
• 第4回Young Investigator's Awardの報告

  辛川 領; 前田 祐佳; 西川 拓也; 木阪 智彦; 坪子 侑佑; 木村 雄亮; 朔 啓太; 塩澤 成弘; 永岡 隆; 黒田 嘉宏; 荒船 龍彦  生体医工学  59-  (4-5)  127  -130  2021/09
• 第3回Young Investigators Awardの報告

  木阪 智彦; 坪子 侑佑; 木村 雄亮; 朔 啓太; 辛川 領; 塩澤 成弘; 永岡 隆; 黒田 嘉宏; 荒船 龍彦  生体医工学  58-  (4-5)  188  -191  2020/09
• 第15回生体医工学サマースクール実施報告

  荒船,龍彦; 黒田,嘉宏; 永岡,隆; 西川,拓也; 前田,祐佳; 桑名,健太  Transactions of Japanese Society for Medical and Biological Engineering  56-  (4)  168  -170  2018
• 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価

  山田 誉大; 木村 裕一; 藤井 康介; 渡辺 翔吾; 永岡 隆; 花岡 宏平; 細川 知紗; 石井 一成; 村上 卓道  核医学  54-  (Suppl.)  S210  -S210  2017/09
• Medical and Biological Engineering Platform of the Young Researchers, by the Young Researchers, for the Young Researchers - Starting from Healthcare Hackathon -

  黒田 嘉宏; 永岡 隆; 塩澤 成弘; 福満 雅史; 荒船 龍彦  Transactions of Japanese Society for Medical and Biological Engineering  55-  (4)  366  -366  2017
• 学会紹介 第13回生体医工学サマースクール : ヘルスケアハッカソンの試み

  黒田 嘉宏; 荒船 龍彦; 永岡 隆; 大須賀 美恵子  生体医工学 = Transactions of Japanese Society for Medical and Biological Engineering : 日本エム・イー学会誌  54-  (4)  194  -196  2016/08
• がんの超早期診断に資するマルチスペクトルカメラの開発

  NAGAOKA TAKASHI  中谷電子計測技術振興財団年報  (24)  92  -103  2010/08
• 表在性腫瘍や血管障害を診断することができるマルチスペクトルカメラの開発とその表示法の開発

  NAGAOKA TAKASHI; MOCHIZUKI TOORU; SOTA TAKAYUKI; NAKAMURA ATSUSHI  村田学術振興財団年報  (21)  370  -378  2007/12
• カプセル型医用機器等の生体内位置計測に適した小型位置センサの開発とその応用

  NAGAOKA TAKASHI; UCHIYAMA AKIHIKO; TAKEDA SUNAO  マツダ財団研究報告書(科学技術振興関係)  19-  39  -42  2007/06
• 永久磁石を用いた生体内三次元位置センサの開発とその応用

  NAGAOKA TAKASHI; UCHIYAMA AKIHIKO  立石科学技術振興財団助成研究成果集  (15)  52  -55  2006/09
• カプセル内視鏡などのカプセル型生体計測機器に適した三次元位置計測センサの開発とセンサを用いた腸ぜん動運動機能の計測

  NAGAOKA TAKASHI  医科学応用研究財団研究報告  23-  72  -77  2006/02

Industrial Property Rights

• 特許6437466:化粧品の皮膚に対する美容効果を評価するための方法  2018/11/22

  戸塚 広乃, ウンスク・キム, ドミニク・バティス, クリストフ・アジュール, 宗田 孝之, 永岡 隆  ロレアル  201603019668205856
• 特許第5565765号:メラノーマ鑑別指標の導出方法  2014/06/27

  宗田 孝之, 會沢 勝夫, 大坪 真也, 永岡 隆, 清原 祥夫  学校法人早稲田大学, 静岡県  201403001161004601
• 特開2014-023603:睡眠時無呼吸判定装置  2014/02/06

  倉橋 宗重, 小林 尚史, 武田 朴, 永岡 隆, 阿部 直, 浦野 哲哉, 青木 琢也, 辻 千鶴子  日本光電工業株式会社, 学校法人早稲田大学, 学校法人東海大学  201403041268070080
• 特許第5408527号:メラノーマ診断用画像の作成方法  2013/11/15

  宗田 孝之, 中村 厚, 大坪 真也, 會沢 勝夫, 永岡 隆, 清原 祥夫  学校法人早稲田大学, 静岡県  201403095347551950
• 特開2010-051589:非侵襲ヒト皮膚メラニン計測法及びその装置  2010/03/11

  宗田孝之, 中村厚, 大坪真也, 會沢勝夫, 永岡隆, 古川雅代  学校法人早稲田大学, 静岡県, 一丸ファルコス株式会社  201003093151095644
• 特開2007-173894:点光源撮影画像の補正装置および補正方法  2007/07/05

  永岡 隆, 宗田 孝之, 會沢 勝夫, 中村 厚, 大坪 真也  学校法人早稲田大学, テクノスマート株式会社  200903009382720388

Awards & Honors

• 2024/02 SPIE Honorable Mention Poster Award
   Unsupervised lung lesion detection on FDG-PET/CT images by deep image transformation-based 2.5-dimensional local anomaly detection. 

  受賞者: A Segawa;M Nemoto;H Kaida;Y Kimura;T Nagaoka;K Mikami;T Yamada;K Hanaoka;T Tsuchiya;K Kitajima;K Ishii
• 2022/06 日本生体医工学会 臨床工学技士研究発表 奨励賞
   深層画像生成技術を用いたFDG-PET/CT像異常検知による病変強調 

  受賞者: 瀬川新;根本充貴;甲斐田勇人;山口明乃;木村裕一;永岡隆;山田誉大;北島一宏;石井一成
• 2019/06 日本生体医工学会 Young Investigator's Award
   深層畳み込みオートエンコーダーを用いた健常データの教師無し学習による病変認識特徴量の汎用的自動生成 japan_society 

  受賞者: 牛房和之;根本充貴;木村裕一;永岡隆;山田誉大;林直人
• 2017/09 日本生体医工学会 生体医工学シンポジウム2017ベストレビューワーアワード
   

  受賞者: 永岡 隆
• 2017/07 公益社団法人日本青年会議所 超生産性向上大賞 文部科学大臣賞
   超ライフの創出 ～ゆりかごのデータから墓場のデータまで～ 

  受賞者: 近畿大学生物理工学部生命情報工学科
• 2017/07 公益社団法人日本青年会議所 超生産性向上大賞 内閣総理大臣賞
   超ライフの創出 ～ゆりかごのデータから墓場のデータまで～ 

  受賞者: 近畿大学生物理工学部生命情報工学科
• 2015/09 日本生体医工学会 生体医工学シンポジウム2015ベストレビューワーアワード
   

  受賞者: 永岡 隆
• 2009/12 公益社団法人 計測自動制御学会 SI2009 優秀講演賞
   

  受賞者: 永岡 隆
• 2009/02 公益社団法人 計測自動制御学会 計測自動制御学会学術奨励賞 研究奨励賞
   

  受賞者: 永岡 隆
• 2003/08 一般社団法人電気学会 電気学会C部門研究会優秀論文発表賞
   

  受賞者: 永岡 隆

Research Grants & Projects

• 深層学習によるメラノーマの自動診断システムの開発

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2020/04 -2023/03 

  Author : 永岡 隆

   

  深層学習を用いたメラノーマの自動診断システム開発に向け、要素技術の開発に取り組んだ。具体的には、AIの視野を集中させる手法の開発、敵対的生成ネットワークによるデータ加増を用いた深層学習の訓練法の開発、深層学習とサポートベクターマシーンを組み合わせ、少ないデータでも識別器が訓練できる手法の開発、mix-up、random croppingなどのデータ加増による診断性能向上の検証、その他最新の知見を取り入れた新規ネットワーク構造の採用・検討などに取り組んだ。 視野の集中に関しては、深層学習に色素病変の部分だけを投入する手法を複数組み合わせ、診断性能の向上が確認された。加増においても、中心部に病変部が残る形で、周辺の皮膚のみを差し替えることで正診率が向上する効果が確認された。深層学習はどの部分を見て診断したのかを明らかにする、ホワイトボックス化が進んでおり、本研究もその応用として実施。深層学習に見て欲しい部分をより強調して提示することで、診断性能が向上することが確認されつつある。より積極的に視野を限定するため、病変部を正確に抽出し、そのマスクを深層学習の特徴マップに重畳する手法の検討を今後進める。 本邦ではメラノーマ患者が少ない事などを鑑み、複数のデータ加増手法による診断性能の向上にも取り組んだ。今年度はパッチ加増の有用性について検証し、弱いパッチ加増がメラノーマ診断に有効であることが確認された。前述の病変部周囲のみを差し替えることによる加増効果が確認されつつあり、本研究による加増が人工知能の学習に有用であることが判明した。 今後はメラノーマ以外の希少病変、例えばCOVID-19のCTデータなどを対象に、ビックデータが必要な深層学習の訓練に資する手法の開発に取り組む予定である。
• Practical clinical development of AI-based coronavirus pneumonia diagnosis support system (KindAI COVID19)

  Kindai University：All-Kindai University support project against COVID-19

  Date (from‐to) : 2020/04 -2021/03 

  Author : 木村裕一; 永岡隆; 石井一成; 小塚健倫; 山田誉大; 根本充貴; 半田久志; 阿部孝司; 波部斉; 多田昌裕; 吉田久
• Development and application of multi-purpose cancer diagnosis system using hyper spectral imaging technique

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2014 -2016 

  Author : NAGAOKA Takashi

   

  In this study, clinical practical application of hyper spectral imaging technology was examined. A quantitative evaluation index of cosmetics was also developed. Hyperspectral imager costs higher. By diverting the parts of existing equipment, it turned out that it can be trial-manufactured inexpensively. Experiments with healthy volunteers were conducted as a development of a cosmetic evaluation system. As a result of the analysis, effective quantitative evaluation method of cosmetics was established.
• Cancer diagnostic system using hyperspectral imaging technique

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(若手研究(B))

  Date (from‐to) : 2011 -2013 

  Author : Takashi NAGAOKA

   

  Cancer diagnostic system using hyperspectral imaging technique was newly developed. In paticular, melanoma diagnosis support system suitable for clinical field was newly developed and its practicality was verifyed. The system succeed in collecting the 200 cases without a trouble and achieved high accuracy (over 90% in sensitivity and specificity). Hyperspectral imaging system for endscopy was also developed and verifyed by animal experiment. It was confirmed that the system can measure spectra in a digestive tract. Clinical test in Swedish area is planned from now on aiming at the global launch of the melanoma diagnosis device.
• 表在性腫瘍や血管障害を診断することができるマルチスペクトルカメラの開発とその表示法の開発

  公益財団法人 村田学術振興財団：2007年度研究助成

  Date (from‐to) : 2007/04 -2008/03 

  Author : 永岡 隆
• がんの超早期診断に資するマルチスペクトラルカメラの開発

  財団法人中谷電子計測技術振興財団：第24回（平成19年度）研究助成

  Date (from‐to) : 2007/04 -2008/03 

  Author : 永岡 隆
• A hyperspectral melanoma screening system

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(若手研究(A))

  Date (from‐to) : 2007 -2008 

  Author : Takashi NAGAOKA

   

  我々はハイパースペクトル(HS)・イメージング技術を用いた診断システムの開発研究を行っている。本システムによる計測の同意が得られた被験者を計測した。スペクトルをベクトルとみなし、基準ベクトルとのなす角を計算した。得られた角度分布マップのフラクタル次元を鑑別指標と定義し、この指標の有用性を統計的手法を用い確認した。感度は84%、特異度は90%であった。本鑑別指標は悪性腫瘍の特徴を反映した高性能な指標になり得ると考えられる。
• 永久磁石を用いた生体内三次元位置センサの開発とその応用

  公益財団法人 立石科学技術振興財団：平成17年度研究助成

  Date (from‐to) : 2005/04 -2006/03 

  Author : 永岡 隆
• カプセル型内視鏡の位置検出に適した無線式三次元位置センサの開発

  公益信託 小澤・吉川記念エレクトロニクス研究助成基金助成金：

  Date (from‐to) : 2004/04 -2005/03 

  Author : 永岡 隆
• カプセル型医用機器等の生体内位置計測に適した小型位置センサの開発とその応用

  公益財団法人 マツダ財団：第20回（2004年度）マツダ研究助成

  Date (from‐to) : 2004/04 -2005/03 

  Author : 永岡 隆
• 生体内に適した無線式三次元位置センサの開発と応用

  財団法人 倉田記念日立科学技術財団：第37回（平成16年度）倉田奨励金

  Date (from‐to) : 2004/04 -2005/03 

  Author : 永岡 隆
• カプセル型生体内三次元位置センサの開発と その応用

  公益財団法人 カシオ科学振興財団：第22回（平成16年度）研究助成

  Date (from‐to) : 2004/04 -2005/03 

  Author : 永岡 隆
• カプセル内視鏡などのカプセル型生体計測機器に適した三次元位置計測センサの開発とセンサを用いた腸蠕動運動機能の計測

  公益財団法人 鈴木謙三記念医科学応用研究財団：2003年度 研究助成

  Date (from‐to) : 2003/04 -2005/03 

  Author : 永岡 隆
• 消化管内出血部位検知センサの開発

  文部科学省：科学研究費補助金(萌芽研究)

  Date (from‐to) : 2005 -2005 

  Author : 永岡 隆

   

  無線カプセル型機器の生体内での3次元位置情報は,X線などの被爆無しに長時間正確に計測することができない.本研究では,生体内の3次元位置を非侵襲かつリアルタイムに計測することができるシステムの開発を目的とした.本システムは,マーカである小型永久磁石,平面磁界センサアレイとその駆動回路,磁界測定値の集計・計算・表示装置であるPCにより構成されている.本研究ではカプセル内視鏡の直径に合わせφ8mm×3.8mmの希土類ネオジウム磁石を採用した.磁界の計測を行なうセンサアレイには,縦横それぞれ50mm間隔で3×3の格子状に磁界センサ9個を配置した.このセンサアレイ2個を300mm間隔で正対させて配置し,センサアレイ間における磁石の位置を測定対象とした.各センサから駆動回路,A/Dコンバーターを介した後にPCへと磁界分布が集積される.PCでは,永久磁石を磁気双極子とみなし,磁気双極子から発生する磁界の理論値と実測値との差が最小となる値を,永久磁石の空間位置座標として算出する.最適値の算出にはガウス・ニュートン法を用いた.これまではフラックスゲート素子を採用していたが、計測可能な最小磁界が10mGと大きいため,システムの計測範囲が狭いことが問題であった.そこで,0.1mG〜2Gまでの測定が可能であるAMR素子を採用した.また,センサに変更に伴い駆動回路,プログラムを改良した.磁気センサの感度軸方向について測定した結果,7mG付近までは計測電圧と真値との誤差が10%を下回った.この素子を利用して,フラックスゲート素子により構築したシステムと同じシステムを構築する場合,計測範囲を400mmまで広げることが可能となる.駆動回路の改良により計測可能な最小磁界をさらに小さくすることを予定している.

Teaching Experience

Basic Technical Course of English for Biological Systems EngineeringBasic Technical Course of English for Biological Systems Engineering Kindai University
Electronic Measurement and Its Application to Biological SystemsElectronic Measurement and Its Application to Biological Systems Kindai University
Electronic CircuitsElectronic Circuits Kindai University
Fundamental Experiments of Information TechnologyFundamental Experiments of Information Technology Kindai University
Exercises of Fundamental Mathematics 1Exercises of Fundamental Mathematics 1 Kindai University
BiosensorBiosensor Kindai University

Media Coverage

• コロナ肺炎症状の自動診断

  Date : 2022/04/06

  Publisher, broadcasting station: わかやま新報

  Program, newspaper magazine: わかやま新報

  朝刊6面 Paper
• AI時代を勝ち抜くアイデアが集結。日本青年会議所主催「超生産性向上大賞」に注目

  Date : 2017/11

  Writer: Other than myself

  Publisher, broadcasting station: リンクタイズ株式会社

  Program, newspaper magazine: Forbes JAPAN

  164ページ Paper
• 生物理工学部生命情報工学科が超生産性向上大賞受賞！ 内閣総理大臣賞と文部科学大臣賞のダブル受賞

  Date : 2017/08

  Writer: Other than myself

  Publisher, broadcasting station: 財経新聞

  Program, newspaper magazine: 財経新聞

  オンライン版 Paper
• 診断装置開発で意見交換

  Date : 2014/02

  Writer: Other than myself

  Publisher, broadcasting station: 静岡新聞

  Program, newspaper magazine: 静岡新聞

  朝刊23面 Paper
• どんとこい未来技術 「医療、環境分野で着実な実績」 早稲田大学・県立静岡がんセンター 診断数値化 がんを早期発見

  Date : 2008/09

  Writer: Other than myself

  Publisher, broadcasting station: 株式会社日本経済新聞社

  Program, newspaper magazine: 日経産業新聞

  第二部A7面 Paper

Others

• 2017/04 -2017/04  ハイパースペクトラルイメージャによる皮膚科学研究 

  近畿大学学内研究助成金 奨励研究助成金 SR14 研究内容：この研究は、臨床での広い普及を目指した新規スペクトル解析手法の確立を目的とする。本研究ではシステムに機械学習並びに深層学習の導入を推進。正診率の向上が確認された。また、メラノーマ診断以外への応用として、化粧品分野の定量的評価法の確立を進める。その研究の一環で、皮膚色と血液成分の相関が見いだされ、今後実用化に向けた研究を進める。

Other link

researchmap

https://researchmap.jp/nagabu