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HYODO Tomoko

    Department of Medicine　Associate Professor
Last Updated :2024/04/19

Researcher Information

Degree

  • MD（2013/03 Ehime University）

URL

Research funding number

  • 40403836

ORCID ID

J-Global ID

Research Interests

  • Radiology   medicine   MRI   CT   diagnostic radiology   

Research Areas

  • Life sciences / Radiology

Association Memberships

  • JAPANESE SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE   JAPANESE SOCIETY OF GASTROENTEROLOGY   Radiological Society of North America   JAPAN RADIOLOGICAL SOCIETY   

Published Papers

  • Ken Kamata; Hajime Imai; Hisakazu Matsumoto; Yukitaka Yamashita; Takao Kato; Katsuhisa Nishi; Shunsuke Omoto; Kosuke Minaga; Kentaro Yamao; Tomoko Hyodo; Sung‐Woon Im; Akane Hara; Tomoe Yoshikawa; Rei Ishikawa; Ayana Okamoto; Tomohiro Yamazaki; Atsushi Nakai; Kazuomi Ueshima; Yasutaka Chiba; Mamoru Takenaka; Tomohiro Watanabe; Masayuki Kitano; Masatoshi Kudo
    JGH Open Wiley 7 (9) 659 - 666 2397-9070 2023/09 
    Abstract Background and Aim A multicenter, open‐label randomized Phase II trial was conducted to determine whether low‐dose gemcitabine plus nab‐paclitaxel (GnP) could improve tolerability and show equivalent efficacy to the standard‐dose GnP for elderly patients with metastatic pancreatic cancer. Methods Consecutive patients aged ≥65 years with metastatic pancreatic cancer who presented at one of four Japanese referral centers between November 2016 and January 2021 were enrolled. The 60 patients were randomly assigned to low‐ or standard‐dose groups with a 1:1 ratio. Patients in the low‐dose GnP group received gemcitabine at a dose of 250 mg/m2 and nab‐paclitaxel at 125 mg/m2. Results Low‐dose GnP significantly decreased the rate of cases requiring dose reduction (16.7% vs 63.3%). The response rate (36.7% vs 33.3%) and progression‐free survival (7.3 vs 8 months) were comparable between the low‐ and standard‐dose groups as determined by independent review. The difference in the median overall survival between the two groups was not significant (7.9 vs 12 months). The proportion of patients with hematologic and non‐hematologic treatment‐related adverse events was comparable between the two groups. Conclusion Low‐dose GnP had an equivalent efficacy to conventional therapy; however, it did not reduce adverse events.
  • Yujiro Nakazawa; Masahiro Okada; Tomoko Hyodo; Kenichiro Tago; Kazu Shibutani; Mariko Mizuno; Hiroki Yoshikawa; Hayato Abe; Tokio Higaki; Yukiyasu Okamura; Tadatoshi Takayama
    European radiology [in press] 2023/09 [Refereed]
     
    OBJECTIVES: To compare the efficacy of computed tomography volumetry (CTV), technetium99m galactosyl-serum-albumin (99mTc-GSA) scintigraphy, and gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced MRI (EOB-MRI) in estimating the liver fibrosis (LF) stage in patients undergoing liver resection. METHODS: This retrospective study included 91 consecutive patients who had undergone preoperative dynamic CT and 99mTc-GSA scintigraphy. EOB-MRI was performed in 76 patients. CTV was used to measure the total liver volume (TLV), spleen volume (SV), normalised to the body surface area (BSA), and liver-to-spleen volume ratio (TLV/SV). 99mTc-GSA scintigraphy provided LHL15, HH15, and GSA indices. The liver-to-spleen ratio (LSR) was calculated in the hepatobiliary phase of EOB-MRI. Hyaluronic acid and type 4 collagen levels were measured in 65 patients. Logistic regression and receiver operating characteristic (ROC) analyses were performed to identify useful parameters for estimating the LF stage and laboratory data. RESULTS: According to the multivariable logistic regression analysis, SV/BSA (odds ratio [OR], 1.01; 95% confidence interval [CI], 1.003-1.02; p = 0.011), LSR (OR, 0.06; 95%CI, 0.004-0.70; p = 0.026), and hyaluronic acid (OR, 1.01; 95%CI, 1.001-1.02; p = 0.024) were independent variables for severe LF (F3-4). Combined SV/BSA, LSR, and hyaluronic acid correctly estimated severe LF, with an AUC of 0.91, which was significantly larger than the AUCs of the GSA index (AUC = 0.84), SV/BSA (AUC = 0.83), or LSR (AUC = 0.75) alone. CONCLUSIONS: Combined CTV, EOB-MRI, and hyaluronic acid analyses improved the estimation accuracy of severe LF compared to CTV, EOB-MRI, or 99mTc-GSA scintigraphy individually. CLINICAL RELEVANCE STATEMENT: The combined analysis of spleen volume on CT volumetry, liver-to-spleen ratio on gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced MRI, and hyaluronic acid can identify severe liver fibrosis associated with a high risk of liver failure after hepatectomy and recurrence in patients with hepatocellular carcinoma. KEY POINTS: • Spleen volume of CT volumetry normalised to the body surface area, liver-to-spleen ratio of EOB-MRI, and hyaluronic acid were independent variables for liver fibrosis. • CT volumetry and EOB-MRI enable the detection of severe liver fibrosis, which may correlate with post-hepatectomy liver failure and complications. • Combined CT volumetry, gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced MRI (EOB-MRI), and hyaluronic acid analyses improved the estimation of severe liver fibrosis compared to technetium99m galactosyl-serum-albumin scintigraphy.
  • Azusa Miura; Nobuo Kashiwagi; M. Sakai; Tomoko Hyodo; Hiroto Takahashi; Yumiko Miyauchi; Osamu Maenishi; Kazunari Ishii; Katsuyuki Nakanishi; Noriyuki Tomiyama
    Clinical Radiology 77 (12) 935 - 942 0009-9260 2022/10 [Refereed]
     
    Aim: To identify the magnetic resonance imaging (MRI) features of metastases to the extraocular muscles (EOM metastases). Material and methods: The MRI features of 19 patients with EOM metastases were compared with those of 24 patients with EOM diseases of non-thyroid origin. MRI was used to assess the number of tumours, morphology, signal intensity on T2-weighted images, enhancement patterns, and apparent diffusion coefficient (ADC) values. Results: Single muscular involvement was observed in 10 patients, and multiple muscular involvement was observed in nine patients. The morphology was focally discrete in nine patients, and diffuse infiltrative in 10 patients; all the nine patients with focal discrete morphology presented with single muscular lesions. On T2-weighted images, the signal intensities were intermediate or low in 15 patients and a mixture of high and intermediate in four patients. In 14 patients for whom contrast-enhanced images were available, ring enhancement (n=5), heterogeneous diffuse enhancement (n=5), and homogeneous enhancement (n=4) were seen. The mean ADC value was 0.98 × 10−3 mm2/s. Compared to other EOM diseases of non-thyroid origin, single muscular presentation, focal discrete morphology, the presence of hyperintensity on T2-weighted images, and ring or heterogeneous enhancement were significantly more frequent in EOM metastases. Conclusion: The MRI features of EOM metastases showed two main patterns: a single discrete mass and multiple infiltrative masses. In addition to the presentation as a single discrete mass, the presence of hyperintensity on T2-weighted images and ring or heterogeneous enhancement can aid in the differentiation of EOM metastases from other EOM diseases.
  • 外眼筋転移のMRI所見 他の非甲状腺性外眼筋腫瘤との比較
    三浦 あづさ; 柏木 伸夫; 酒井 美緒; 中西 克之; 兵頭 朋子; 石井 一成; 高橋 洋人; 綿谷 朋大; 崎須賀 敬央; 松尾 千聡; 有澤 亜津子; 富山 憲幸
    日本医学放射線学会秋季臨床大会抄録集 (公社)日本医学放射線学会 58回 S402 - S402 0048-0428 2022/08
  • Hidekazu Tanaka; Kosuke Minaga; Yasuo Otsuka; Yasuhiro Masuta; Ken Kamata; Kentaro Yamao; Mamoru Takenaka; Tomoko Hyodo; Masatomo Kimura; Tomohiro Watanabe; Masatoshi Kudo
    Frontiers in Medicine Frontiers Media SA 9 951834 - 951834 2022/07 [Refereed]
     
    Background Pancreatic neuroendocrine carcinoma (PanNEC) is a rare disease entity with rapid progression and poor prognosis. Here, we report a PanNEC case with unique morphological features mimicking intraductal papillary mucinous carcinoma. Case presentation A 69-year-old Japanese man was referred to our hospital for further evaluation of weight loss and deterioration of diabetes mellitus. Contrast-enhanced computed tomography showed a solid and cystic mass with hypo-enhancement at the tail of the pancreas. The main pancreatic duct (MPD) was diffusely dilated without obstruction, accompanied by marked parenchymal atrophy. Multiple peritoneal and omental nodules were observed, suggesting tumor dissemination. Endoscopic retrograde cholangiopancreatography revealed that the mass correlated with the dilated MPD. During pancreatography, a large amount of mucus was extruded from the pancreatic orifice of the ampulla. Based on these imaging findings, intraductal papillary mucinous carcinoma was suspected. Per-oral pancreatoscopy (POPS)-guided tumor biopsies were conducted for the lesion's solid components. Histopathological examination of the biopsied material confirmed small-cell-type PanNEC with a Ki-67 labeling index of 90%. Due to his condition's rapid decline, the patient was given the best supportive care and died 28 days after diagnosis. Conclusion Although rare, PanNEC, which correlates with the MPD and is accompanied by marked dilation of the MPD, does exist as one phenotype. In such cases, POPS-guided biopsy could be a useful diagnostic modality.
  • Atsushi Nakai; Ken Kamata; Tomoko Hyodo; Takaaki Chikugo; Akane Hara; Yasuo Otsuka; Hidekazu Tanaka; Tomoe Yoshikawa; Rei Ishikawa; Ayana Okamoto; Tomohiro Yamazaki; Shunsuke Omoto; Kosuke Minaga; Kentaro Yamao; Mamoru Takenaka; Yasutaka Chiba; Tomohiro Watanabe; Ippei Matsumoto; Yoshifumi Takeyama; Masatoshi Kudo
    Endoscopic Ultrasound Medknow 11 (5) 401 - 406 2303-9027 2022/07 [Refereed]
     
    BACKGROUND: The value of contrast-enhanced harmonic EUS (CH-EUS) for diagnosis of portal vein invasion in patients with pancreatic cancer was evaluated. PATIENTS AND METHODS: This single-center, retrospective study included consecutive patients with pancreatic cancer who underwent both surgical resection after preoperative EUS, CH-EUS, and contrast-enhanced computed tomography (CE-CT) examinations between April 2015 and August 2017. CH-EUS evaluation was performed during the late phase. Portal vein invasion on EUS and CH-EUS was defined as no continuity in the line of the vessel wall. Definition of portal vein invasion on CE-CT was based on the Loyer's criteria. The accuracy of three modalities for diagnosis of invasion into the portal vein was compared using the McNemar's test. RESULTS: Eighty-eight patients (mean age: 71.0 years, ratio of male to female: 48:40) were eligible. Postoperative pathological results were as follows: seven cases of portal vein invasion; 81 cases without. Diagnostic accuracy of EUS, CH-EUS, and CE-CT for diagnosing invasion into the portal vein was 72.7%, 93.2%, and 81.8%, respectively. The differences between CH-EUS and CE-CT (P = 0.0094) and CH-EUS and EUS (P = 0.0022) were significant. EUS and CE-CT were comparable. CONCLUSION: CH-EUS is useful for diagnosis of portal vein invasion by pancreatic cancer.
  • Daisuke Morimoto-Ishikawa; Tomoko Hyodo; Mamoru Takenaka; Yuko Matsukubo; Isao Numoto; Makoto Itoh; Masato Ohmi; Ken Kamata; Yu Ueda; Miyuki Wakana; Masatoshi Kudo; Shigeyoshi Saito; Kazunari Ishii
    European Journal of Radiology Elsevier BV 150 110279 - 110279 0720-048X 2022/05 [Refereed]
  • Yasuo Otsuka; Ken Kamata; Tomoko Hyodo; Takaaki Chikugo; Akane Hara; Hidekazu Tanaka; Tomoe Yoshikawa; Rei Ishikawa; Ayana Okamoto; Tomohiro Yamazaki; Atsushi Nakai; Shunsuke Omoto; Kosuke Minaga; Kentaro Yamao; Mamoru Takenaka; Yasutaka Chiba; Tomohiro Watanabe; Takuya Nakai; Ippei Matsumoto; Yoshifumi Takeyama; Masatoshi Kudo
    Surgical Endoscopy Springer Science and Business Media LLC 36 (5) 3254 - 3260 0930-2794 2022/05 [Refereed]
     
    BACKGROUND: The value of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for T-staging in patients with extrahepatic bile duct cancer was evaluated. METHODS: This single-center, retrospective study included consecutive patients with extrahepatic bile duct cancer who underwent surgical resection after preoperative EUS, CH-EUS, and contrast-enhanced CT (CE-CT) examinations between June 2014 and August 2017. The capacity of these modalities for T-staging of extrahepatic bile duct cancer was evaluated by assessing invasion beyond the biliary wall into the surrounding tissue, gallbladder, liver, pancreas, duodenum, portal vein system (portal vein and/or superior mesenteric vein), inferior vena cava, and hepatic arteries (proper hepatic artery, right. and/or left. hepatic artery). Blind reading of EUS, CH-EUS, and CE-CT images was performed by two expert reviewers each. RESULTS: 38 patients were eligible for analysis, of which eight had perihilar bile duct cancer and 30 had distal bile duct cancer. Postoperative T-staging was T1 in 6, T2 in 16, and T3 in 16 cases. CH-EUS was superior to CE-CT for diagnosing invasion beyond the biliary wall into surrounding tissue (92.1% vs. 45.9%, P = 0.0002); the ability to detect invasion to other organs did not differ significantly between the two modalities. The accuracy of CH-EUS for T-staging of tumors was better than that of CE-CT (73.7% vs. 39.5%, P = 0.0059). CH-EUS tended to have a better accuracy than EUS for the diagnosis of invasion beyond the biliary wall into the surrounding tissue (92.1% vs. 78.9%, P = 0.074) and T-staging (73.7% vs. 60.5%, P = 0.074). CONCLUSION: CH-EUS is useful for T-staging of extra hepatic bile duct cancer, especially in terms of invasion beyond the biliary wall into the surrounding tissue.
  • Rei Ishikawa; Ken Kamata; Akane Hara; Hidekazu Tanaka; Ayana Okamoto; Tomohiro Yamazaki; Atsushi Nakai; Shunsuke Omoto; Kosuke Minaga; Kentaro Yamao; Mamoru Takenaka; Yasunori Minami; Tomohiro Watanabe; Yasutaka Chiba; Takaaki Chikugo; Ippei Matsumoto; Yoshifumfi Takeyama; Yuko Matsukubo; Tomoko Hyodo; Masatoshi Kudo
    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 33 (5) 829 - 839 2021/07 [Refereed]
     
    BACKGROUND AND AIMS: Pancreatic neuroendocrine neoplasms (PanNENs), including Grade 1 (G1) or G2 tumors, can have a poor prognosis. This study investigated the value of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for predicting the prognosis of PanNENs. METHODS: This single-center, retrospective study included 47 consecutive patients who underwent CH-EUS and were diagnosed with PanNEN by surgical resection or EUS-guided fine needle aspiration between December 2011 and February 2016. Patients were divided into aggressive and non-aggressive groups according to the degree of clinical malignancy. CH-EUS was assessed regarding its capacity for diagnosing aggressive PanNEN, the correspondence between contrast patterns and pathological features, and its ability to predict the prognosis of PanNEN. RESULTS: There were 19 cases of aggressive PanNEN and 28 cases of non-aggressive PanNEN. The aggressive group included three G1, four G2, three G3 tumors, three mixed neuroendocrine non-neuroendocrine neoplasms, and six neuroendocrine carcinomas. CH-EUS was superior to contrast-enhanced computed tomography for the diagnosis of aggressive PanNEN (P < 0.001): hypo-enhancement on CH-EUS was an indicator of aggressive PanNEN, with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 94.7%, 100%, 100%, 96.6%, and 97.9%, respectively. Among G1/G2 PanNENs, cases with hypo-enhancement on CH-EUS had a poorer prognosis than those with hyper/iso-enhancement (P = 0.0009). Assessment of 36 resected specimens showed that hypo-enhancement on CH-EUS was associated with smaller and fewer vessels and greater degree of fibrosis. CONCLUSION: Contrast-enhanced harmonic endoscopic ultrasonography may be useful for predicting the prognosis of PanNENs.
  • Kazu Shibutani; Masahiro Okada; Jitsuro Tsukada; Tomoko Hyodo; Kenji Ibukuro; Hayato Abe; Naoki Matsumoto; Yutaka Midorikawa; Mitsuhiko Moriyama; Tadatoshi Takayama
    BJR open 3 (1) 20210019 - 20210019 2021/09 [Refereed]
     
    Objective: To develop a model for predicting post-operative major complications in patients with hepatocellular carcinoma (HCC). Methods: In all, 186 consecutive patients with pre-operative MR elastography were included. Complications were categorised using Clavien‒Dindo classification, with major complications defined as ≥Grade 3. Liver-stiffness measurement (LSM) values were measured on elastogram. The indocyanine green clearance rate of liver remnant (ICG-Krem) was based on the results of CT volumetry, intraoperative data, and ICG-K value. For an easy application to the prediction model, the continuous variables were converted to categories. Moreover, logistic regression analysis and fivefold cross-validation were performed. The prediction model's discriminative performance was evaluated using the area under the receiver operating characteristic curve (AUC), and the calibration of the model was assessed by the Hosmer‒Lemeshow test. Results: 43 of 186 patients (23.1%) had major complications. The multivariate analysis demonstrated that LSM, albumin-bilirubin (ALBI) score, intraoperative blood loss, and ICG-Krem were significantly associated with major complications. The median AUC of the five validation subsets was 0.878. The Hosmer-Lemeshow test confirmed no evidence of inadequate fit (p = 0.13, 0.19, 0.59, 0.59, and 0.73) on the fivefold cross-validation. The prediction model for major complications was as follows: -2.876 + 2.912 [LSM (>5.3 kPa)]+1.538 [ALBI score (>-2.28)]+0.531 [Intraoperative blood loss (>860 ml)]+0.257 [ICG-Krem (<0.10)]. Conclusion: The proposed prediction model can be used to predict post-operative major complications in patients with HCC. Advances in knowledge: The proposed prediction model can be used in routine clinical practice to identify post-operative major complications in patients with HCC and to strategise appropriate treatments of HCC.
  • Shota Watanabe; Kohei Hanaoka; Hayato Kaida; Tomoko Hyodo; Minoru Yamada; Masakatsu Tsurusaki; Kazunari Ishii
    Asia Oceania journal of nuclear medicine & biology 9 (2) 12 - 149 2021 
    OBJECTIVES: To assess respiratory-gated (RG) positron emission tomography (PET) acquisition for patients with liver metastases during delayed PET/computed tomography (CT) scanning with fluorine-18-fluorodeoxyglucose (18F-FDG). METHODS: Nineteen patients with liver metastases who had undergone early whole-body 18F-FDG PET/CT scans without the RG technique and delayed scans with the RG technique were retrospectively selected. The maximum standardized uptake value (SUVmax) of 41 liver lesions and the tumor-to-liver uptake ratios (TLRs) for these same lesions were compared among three data sets: early non-respiratory-gated (early non-RG) images, delayed non-respiratory-gated (delayed non-RG) images, and delayed respiratory-gated (delayed RG) images. In the delayed non-RG and delayed RG images, the improvements in the TLR, relative to the early non-RG images, were assessed according to lesion size. RESULTS: For liver lesions, the SUVmax of early non-RG, delayed non-RG, and delayed RG images were 6.58±2.34, 7.69±3.08, and 9.47±3.73, respectively. There were significant differences among the three images (P<0.01). The TLR of the delayed RG images was significantly higher than those of the early non-RG and delayed non-RG images (P<0.01). In the delayed RG images, the difference in the TLR improvement for lesions ≤10 mm in size was 15% higher than that for lesions >10 mm in size; in the delayed non-RG images, the difference in the TLR improvement for the same lesion categories was 6%. CONCLUSION: Delayed RG imaging improves the TLR, compared with early non-RG and delayed non-RG imaging, especially for small lesions. RG PET acquisition may be a promising protocol for assessing liver metastases on delayed PET/CT scans.
  • Takenori Kozuka; Yuko Matsukubo; Tomoya Kadoba; Teruyoshi Oda; Ayako Suzuki; Tomoko Hyodo; SungWoon Im; Hayato Kaida; Yukinobu Yagyu; Masakatsu Tsurusaki; Mitsuru Matsuki; Kazunari Ishii
    Japanese Journal of Radiology Springer Science and Business Media LLC 38 (11) 1052 - 1061 1867-1071 2020/11 [Refereed]
     
    PURPOSE: To evaluate the performance of a deep learning-based computer-aided diagnosis (CAD) system at detecting pulmonary nodules on CT by comparing radiologists' readings with and without CAD. MATERIALS AND METHODS: A total of 120 chest CT images were randomly selected from patients with suspected lung cancer. The gold standard of nodules ≥ 3 mm was established by a panel of three expert radiologists. Two less experienced radiologists read the images without and afterward with CAD system. Their reading times were recorded. RESULTS: The radiologists' sensitivity increased from 20.9% to 38.0% with the introduction of CAD. The positive predictive value (PPV) decreased from 70.5% to 61.8%, and the F1-score increased from 32.2% to 47.0%. The sensitivity significantly increased from 13.7% to 32.4% for small nodules (3-6 mm) and from 33.3% to 47.6% for medium nodules (6-10 mm). CAD alone showed a sensitivity of 70.3%, a PPV of 57.9%, and an F1-score of 63.5%. Reading time decreased by 11.3% with the use of CAD. CONCLUSION: CAD improved the less experienced radiologists' sensitivity in detecting pulmonary nodules of all sizes, especially including a significant improvement in the detection of clinically important-sized medium nodules (6-10 mm) as well as small nodules (3-6 mm) and reduced their reading time.
  • Daisuke Morimoto; Tomoko Hyodo; Ken Kamata; Tomoya Kadoba; Makoto Itoh; Hiroyuki Fukushima; Yasutaka Chiba; Mamoru Takenaka; Tomohiro Mochizuki; Yu Ueda; Keizou Miyagoshi; Masatoshi Kudo; Kazunari Ishii
    Abdominal Radiology Springer Science and Business Media LLC 45 (10) 3081 - 3091 2366-004X 2020/10 [Refereed]
  • Ayako Suzuki; Nobuo Kashiwagi; Hiroshi Doi; Kazunari Ishii; Katsumi Doi; Mutsukazu Kitano; Takenori Kozuka; Tomoko Hyodo; Masakatsu Tsurusaki; Yukinobu Yagyu; Katsuyuki Nakanishi
    Auris, nasus, larynx 47 (2) 262 - 267 0385-8146 2020/04 [Refereed]
     
    OBJECTIVE: To report clinical features of bone metastases (BM) from head and neck squamous cell carcinoma (HNSCC). METHODS: Among 772 patients with HNSCC diagnosed at our hospital over 9 years, 30 patients (3.9%) had clinical evidence of BM (24 men and 6 women; mean age: 63 years). We assessed the time interval from the primary diagnosis to BM development, symptoms attributable to BM, presence of distant metastases to other organs, number of BM, sites of BM, morphologic changes on computed tomography (CT) images, treatment for BM, and overall survival (OS). RESULTS: BM at the initial stage were found in 9 patients with HNSCC (30%), and in 21 patients (70%) with HNSCC during the course of the disease. In the later patients, the median time interval from the primary diagnosis was 11.5 months. Nineteen patients (63%) did not have BM-related symptoms, 6 (20%) had pain, 3 (10%) had neurologic symptoms resulting from vertebral or skull metastases, and 2 (7%) had hypercalcemia. Seventeen patients (57%) showed bone-exclusive metastases, and 13 (43%) had distant metastases in other organs. Eleven patients (37%) had monostotic metastases (solitary BM), and 19 patients (63%) had polyostotic metastases (multiple BM). When combined, 9 patients (30%) showed bone-exclusive and monostotic metastases. The most commonly affected site was the thoracolumbar spine, accounting for 34% of total BM, followed by the pelvis (24%), shoulder and thorax (21%), and the extremities (17%). Notably, metastases to bones above the clavicle (craniofacial bones and cervical spine) accounted for only 3% of all bone lesions. CT images showed variable morphologic patterns with osteolytic type in 17 patients (57%), intertrabecular in 7 (23%), osteoblastic in 4 (13%), and mixed in 2 (7%). Systematic chemotherapy for BM was performed in 19 patients and radiotherapy in 18. The median survival time for patients with bone-exclusive and monostotic metastases was significantly longer than that for patients with multi-organ metastases or polyostotic metastases at 18.2 months vs. 5.7 months (p=0.02). Neither chemotherapy nor radiotherapy extended OS. CONCLUSION: Thirty percent of BM cases from HNSCC showed bone-exclusive and monostotic metastases. These patients tended to show a more favorable prognosis than patients with multi-organ metastases or polyostotic metastases.
  • Kromrey ML; Hori M; Goshima S; Kozaka K; Hyodo T; Nakamura Y; Nishie A; Tamada T; Shimizu T; Kanki A; Motosugi U
    European radiology 30 (1) 281 - 290 0938-7994 2020/01 [Refereed]
  • Nobuo Kashiwagi; Tomoko Hyodo; Kazunari Ishi; Osamu Maenishi; Eisuke Enoki; Takaaki Chikugo; Tsurusaki Masakatsu; Yukinobu Yagyu; Mutsukazu Kitano; Noriyuki Tomiyama
    Dento maxillo facial radiology 48 (5) 20180382 - 20180382 0250-832X 2019/07 [Refereed]
     
    OBJECTIVES: To report MRI findings of spontaneous infarction in parotid tumours. METHODS: 14 patients (13 male, 1 female; mean age 73 years) with spontaneously infarcted parotid tumours were reviewed retrospectively. MR images were assessed for the location, the presence of synchronous parotid masses, margin characteristics, signal intensity on T1 and T2 weighted images, and internal architecture according to the distribution of T2 signal hyperintensity. RESULTS: 12 tumours were located in the parotid tail and 2 in the superficial lobe. Synchronous parotid masses were seen in four tumours, three of which were located in the ipsilateral parotid tail and one in the contralateral parotid tail. Seven tumours had well-defined margins and seven had ill-defined margins. The signal intensities on T1 weighted images were a mixture of high and intermediate in all cases; in 11 tumours, hyperintense areas were dominant. On T2 weighted images, all tumours also showed a mixture of high and intermediate signal intensities. Internal architectures on T2 weighted images were mosaic hyperintensity in three tumours, central hyperintensity in five, and multiseparated hyperintensity in six. CONCLUSIONS: Spontaneously infarcted parotid tumours were mostly located in the parotid tail and showed mixed signal intensities with predominant hyperintensity on T1 weighted images. Half of the tumours had ill-defined margins, and the internal architectures varied.
  • 膵癌の門脈浸潤診断における造影ハーモニックEUSと造影CTの診断能の比較検討
    中井 敦史; 鎌田 研; 竹中 完; 石川 嶺; 岡本 彩那; 大本 俊介; 三長 孝輔; 山雄 健太郎; 兵頭 朋子; 松本 逸平; 竹山 宜典; 工藤 正俊
    Gastroenterological Endoscopy (一社)日本消化器内視鏡学会 60 (Suppl.2) 2126 - 2126 0387-1207 2018/10
  • 頭頸部扁平上皮癌からの骨転移
    鈴木 絢子; 柏木 伸夫; 沼本 勲男; 小田 晃義; 門場 智也; 兵頭 朋子; 山田 穣; 甲斐田 勇人; 柳生 行伸; 任 誠雲; 鶴崎 正勝; 小塚 健倫; 松木 充; 石井 一成; 中西 克之
    日本医学放射線学会秋季臨床大会抄録集 (公社)日本医学放射線学会 54回 S470 - S470 0048-0428 2018/09
  • 大塚 康生; 鎌田 研; 竹中 完; 石川 嶺; 岡本 彩那; 中井 敦史; 大本 俊介; 三長 孝輔; 山雄 健太郎; 筑後 孝章; 兵頭 朋子; 中居 卓也; 竹山 宜典; 工藤 正俊
    胆道 日本胆道学会 32 (3) 567 - 567 0914-0077 2018/08
  • Nobuo Kashiwagi; Shin Ichi Nakatsuka; Takamichi Murakami; Eisuke Enoki; Kazuhiro Yamamoto; Katsuyuki Nakanishi; Takaaki Chikugo; Yoshitaka Kurisu; Masatomo Kimura; Tomoko Hyodo; Akio Tsukabe; Takahide Kakigi; Yasuhiko Tomita; Kazunari Ishii; Yoshifumi Narumi; Yukinobu Yagyu; Noriyuki Tomiyama
    Dento maxillo facial radiology 47 (5) 20170218 - 20170218 0250-832X 2018/07 [Refereed]
     
    OBJECTIVES: To report MR imaging features of mammary analogue secretory carcinoma (MASC) and acinic cell carcinoma (AciCC) of the salivary gland based on the latest version of the World Health Organization (WHO) 2017 classification of head and neck tumours. METHODS: MR images in 4 patients with MASC and 4 with AciCC were reviewed for margin characteristics, the presence of pathological cervical nodes, the presence of a cystic component and interface between cystic and solid component, signal intensity of the cystic components on T1 weighted images, and signal intensity of the solid component on T1 and T2 weighted images. RESULTS: All the MASCs and AciCCs had well-defined boundaries, and 1 AciCC had pathological nodes. All 4 MASCs presented as predominantly cystic tumours with papillary projection of the solid component. All 4 AciCCs presented as solid tumours. The signal intensity of the cystic components on T1 weighted images was entirely hyperintense in 2, and partly hyperintense demonstrating fluid-fluid level in 2. In all the MASCs, the signal intensity of the solid components on T1 weighted images was intermediate. In the AciCCs, the signal intensity of the solid components on T1 weighted images was high in 2 tumours and intermediate in 2. The signal intensity of the solid components on T2 weighted images varied from low to high in both MSACs and AciCCs. CONCLUSIONS: All 4 MASCs had a large cystic component, including areas of high signal intensity on T1 weighted images. The solid component appeared as a papillary projection into the cystic component. All 4 AciCCs presented as solid tumours, 2 of which showed high signal intensity on T1 weighted images.
  • Sofue K; Tsurusaki M; Mileto A; Hyodo T; Sasaki K; Nishii T; Chikugo T; Yada N; Kudo M; Sugimura K; Murakami T
    Hepatology research : the official journal of the Japan Society of Hepatology 48 (12) 1008 - 1019 1386-6346 2018/06 [Refereed]
     
    AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy computed tomography (CT) data can non-invasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (non-contrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy. Iodine density of liver and aorta were obtained by two independent observers. Iodine uptake of the liver (Δ Liver), representing the difference in iodine density between equilibrium phase and non-contrast images, was calculated and normalized by aorta (Δ Liver/Aorta). We accounted for contrast agent distribution volume by using hematocrit level. Accuracy of iodine density measurements for staging liver fibrosis was assessed by using receiver operating characteristic (ROC) curves. Multivariate linear regression analysis was used to assess the impact of independent variables (liver fibrosis stage and patient-related confounders) on iodine uptake. RESULTS: The Δ Liver/Aorta significantly increased and moderately correlated with METAVIR liver fibrosis stage (ρ = 0.645, P < 0.001). Areas under the ROC curve ranged from 0.795 to 0.855 for discriminating each liver fibrosis score (≥F1-F4). METAVIR fibrosis stage was the most significant independent factor associated with Δ Liver (P = 0.005) and Δ Liver/Aorta (P < 0.001). CONCLUSION: Hepatic extracellular volume fraction with contrast-enhanced dual-energy CT can non-invasively stage liver fibrosis in chronic liver diseases. This technique could prove useful for monitoring disease progression and treatment response, potentially reducing the need for liver biopsy.
  • Volumetric parameterを用いた食道癌切除患者の予後因子の検討
    甲斐田 勇人; 石井 一成; 細川 知紗; 柳生 行伸; 任 誠雲; 兵頭 朋子; 山田 穣; 細野 眞; 安田 卓司; 村上 卓道
    核医学 (一社)日本核医学会 54 (Suppl.) S193 - S193 0022-7854 2017/09
  • Hideyuki Fukui; Nobuo Kashiwagi; Takamichi Murakami; Yoshiyuki Watanabe; Tomoko Hyodo; Kazunari Ishi; Miho Yamakawa; Hirito Takahashi; Noriyuki Tomiyama
    Japanese Journal of Radiology Springer Science and Business Media LLC 35 (9) 532 - 538 1867-1071 2017/09 [Refereed]
  • Kohei Shimomura; Fujio Araki; Yuki Kono; Yoshiyuki Asai; Takamichi Murakami; Tomoko Hyodo; Masahiko Okumura; Kenji Matsumoto; Hajime Monzen; Yasumasa Nishimura
    Physica Medica Elsevier BV 39 59 - 66 1120-1797 2017/07 [Refereed]
     
    The purpose of this study was to obtain the fraction by weight of the elemental composition and mass density of a humanoid tissue phantom that includes lung tissue, soft tissue, and bone tissue, by using dual energy computed tomography (DECT). The fraction by weight and the mass density for tissue-equivalent materials were calculated by means of a least-squares method with a linear attenuation coefficient, using monochromatic photon energies of 10-140keV, as obtained from DECT. The accuracy of calculated values for the fractions by weight of H (hydrogen), C (carbon), N (nitrogen), and O (oxygen) as verified by comparing the values with those that were analyzed using the combustion technique. The fraction by weight for other elements was confirmed by comparing with the analyzed values by means of energy dispersive photon spectroscopy. The calculated mass densities for each tissue were compared with those that were obtained by dividing the weight by volume. The calculated values of the fraction by weight that were obtained by means of DECT had differences of 1.9%, 9.2%, 6.6%, 7.8%, 0.8%, and 0.2% at a maximum for H, C, N, O, P (phosphorus), and Ca (calcium), respectively, from the reference values analyzed by the combustion technique and energy dispersive photon spectroscopy. The difference in the mass density for tissue was 0.011g/cm3 at a maximum. This study demonstrated the fraction by weight and the mass density of the humanoid tissue-equivalent materials that were calculated by means of DECT were expected high accuracy.
  • Masafumi Toguchi; Masakatsu Tsurusaki; Norihisa Yada; Keitaro Sofue; Tomoko Hyodo; Minori Onoda; Isao Numoto; Mitsuru Matsuki; Izumi Imaoka; Masatoshi Kudo; Takamichi Murakami
    Abdominal Radiology Springer Science and Business Media LLC 42 (6) 1659 - 1666 2366-004X 2017/06 [Refereed]
     
    PURPOSE: To evaluate the quantitative measurement of liver stiffness (LS), compare the diagnostic performance of magnetic resonance elastography (MRE) and ultrasound-based transient elastography (TE), and evaluate two different MRE-based LS measurement methods. METHODS: Between October 2013 and January 2015, 116 consecutive patients with chronic liver disease underwent MRE to measure LS (kilopascals; kPa). Of the 116 patients, 51 patients underwent both TE and liver biopsy, and the interval between the liver biopsy and both the MRE and TE was less than 90 days. MRE-derived LS values were measured on the anterior segment of the right lobe (single small round regions of interest per slice; srROIs) and whole right lobe of the liver (free hand region of interest; fhROI), and these values were correlated with pathological fibrosis grades and diagnostic performance. RESULTS: Pathological fibrosis stage was significantly correlated with srROIs (r = 0.87, p < 0.001), fhROI (r = 0.80, p < 0.001), and TE (r = 0.73, p < 0.001). For detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis, the area under the curve (AUC) associated with the srROIs was largest, and there was a significant difference between srROIs and TE (0.93 vs. 0.82, p = 0.006), srROIs and fhROI (0.93 vs. 0.89, p = 0.04) for detection of ≥F2. For advanced fibrosis and cirrhosis detection, AUCs were not significant (0.92-0.96). CONCLUSIONS: MRE and TE detected liver fibrosis with comparable accuracy. In particular, the srROIs method was effective for detecting of significant fibrosis.
  • Scheiwein FT; Ishii K; Hosokawa C; Kaida H; Hyodo T; Hanaoka K; Brendel M; Bartenstein P; Rominger A; Murakami T
    Journal of Alzheimers Disease & Parkinsonism 7 (2) 317  2017/04 [Refereed]
  • Tomoko Hyodo; Norihisa Yada; Masatoshi Hori; Osamu Maenishi; Peter Lamb; Kosuke Sasaki; Minori Onoda; Masatoshi Kudo; Teruhito Mochizuki; Takamichi Murakami
    Radiology Radiological Society of North America (RSNA) 283 (1) 108 - 118 0033-8419 2017/04 [Refereed]
  • Yuichi Wakabayashi; Kazunari Ishii; Chisa Hosokawa; Tomoko Hyodo; Hayato Kaida; Minoru Yamada; Yukinobu Yagyu; Masakatsu Tsurusaki; Takenori Kozuka; Kazuro Sugimura; Takamichi Murakami
    The Kobe journal of medical sciences 62 (5) E136-E141 - E141 0023-2513 2017/03 [Refereed]
     
    Using 11C-Pittsburgh compound B (PiB)-PET and MRI volume data, we investigated whether white matter (WM) PiB uptake in Alzheimer's disease (AD) brain is larger than that of cortical PiB uptake-negative (PiB-negative) brain. Forty-five subjects who underwent both PiB-PET and MRI were included in the study (32 AD patients with cortical PiB-positive and 13 cortical amyloid -negative patients). Individual areas of gray matter (GM) and WM were segmented, then regional GM and WM standard uptake value ratio (SUVR) normalized to cerebellar GM with partial volume effects correction was calculated. Three regional SUVRs except WM in the centrum semiovale in the AD group were significantly larger than those in the PiB-negative groups. Frontal WM SUVR in the AD group vs frontal WM SUVR in the PiB-negative group was 2.57 ± 0.55 vs 1.64 ± 0.22; parietal, 2.50 ± 0.52 vs 1.74 ± 0.22; posterior cingulate, 2.84 ± 0.59 vs 1.73 ± 0.22; and WM in the centrum semiovale, 2.21 ± 0.53 vs 2.42 ± 0.36, respectively. We found that PiB uptake in AD brain is significantly larger than that in PiB-negative brain in the frontal, parietal and posterior cingulate subcortical WM, except in the centrum semiovale.
  • Tomoko Hyodo; Masatoshi Hori; Peter Lamb; Kosuke Sasaki; Tetsuya Wakayama; Yasutaka Chiba; Teruhito Mochizuki; Takamichi Murakami
    Radiology Radiological Society of North America (RSNA) 282 (2) 381 - 389 0033-8419 2017/02 [Refereed]
  • Tatsuo Inoue; Tomoko Hyodo; Keiko Korenaga; Takamichi Murakami; Yasuharu Imai; Atsushi Higaki; Takeshi Suda; Toru Takano; Kennichi Miyoshi; Masahiko Koda; Hironori Tanaka; Hiroko Iijima; Hironori Ochi; Masashi Hirooka; Kazushi Numata; Masatoshi Kudo
    JOURNAL OF GASTROENTEROLOGY SPRINGER JAPAN KK 51 (2) 144 - 152 0944-1174 2016/02 [Refereed]
     
    Background It remains unknown whether Kupffer-phase images in Sonazoid-enhanced ultrasonography (US) can be used to predict hypervascularization of borderline lesions. Therefore, we aimed to clarify whether Kupffer-phase images in Sonazoid-enhanced ultrasonography can predict subsequent hypervascularization in hypovascular borderline lesions detected on hepatobiliary-phase gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (GdEOB-DTPA)-enhanced magnetic resonance imaging. Methods From January 2008 to March 2012, 616 low-intensity hypovascular nodules were detected in hepatobiliary-phase images of Gd-EOB-DTPA-enhanced MRI at nine institutions. Among these, 167 nodules, which were confirmed as hypovascular by Gd-EOB-DTPA-enhanced MRI and Sonazoid-enhanced US, were evaluated in this study. Potential hypervascularization factors were selected based on their clinical significance and the results of previous reports. The Kaplan-Meier model and log-rank test were used for univariate analysis and the Cox regression model was used for multivariate analysis. Results The cumulative incidence of hypervascularization of borderline lesions was 18, 37, and 43 % at 1, 2, and 3 years, respectively. Univariate analyses showed that tumor size (p = 0.0012) and hypoperfusion on Kupffer-phase images in Sonazoid-enhanced US (p = 0.004) were associated with hypervascularization of the tumor. Multivariate analysis showed that tumor size [HR: 1.086, 95 % confidence interval = 1.027-1.148, p = 0.004] and hypo perfusion on Kupffer-phase images [HR: 3.684, 95 % confidence interval = 1.798-7.546, p = 0.0004] were significantly different. Conclusions Kupffer-phase images in Sonazoid-enhanced US and tumor diameter can predict hypervascularization of hypointense borderline lesions detected on hepatobiliary-phase Gd-EOB-DTPA-enhanced MRI.
  • Chisa Hosokawa; Kazunari Ishii; Yuichi Kimura; Tomoko Hyodo; Makoto Hosono; Kenta Sakaguchi; Kimio Usami; Kenji Shimamoto; Yuzuru Yamazoe; Takamichi Murakami
    JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 56 (12) 1910 - 1915 0161-5505 2015/12 [Refereed]
     
    The goal of this study was to clarify whether binding potential (BP) images using C-11-Pittsburgh compound B (C-11-PiB) and dynamic PET can reliably detect cortical amyloid deposits for patients whose C-11-PiB PET static images are ambiguous and whether visual ratings are affected by white matter retention. Methods: Static and BP images were constructed for 85 consecutive patients with cognitive impairment after C-11-PiB dynamic PET. Cortical uptake was visually assessed as positive, negative, or equivocal for both types of images. Quantitatively, the standardized uptake value ratio (SUVR) from the static image, the nondisplaceable BP from the dynamic image for mean gray matter uptake, and the ratio of gray matter uptake to white matter retention were compared among C-11-PiB-positive, C-11-PiB-equivocal, and C-11-PiB-negative groups. Results: Forty-three scans were visually assessed as C-11-PiB-positive in both the static and the BP images. Ten scans were C-11-PiB-equivocal in the static images. In 8 of them, the BP images were C-11-PiB-positive, whereas the other 2 were C-11-PiB-equivocal. Thirty-two scans were assessed as C-11-PiB-negative in the static images. In the BP images, 4 were C-11-PiB-positive and 2 were C-11-PiB-equivocal. The mean gray matter uptake of C-11-PiB in SUVR and nondisplaceable BP, respectively, showed statistically significant differences among the C-11-PiB-positive, C-11-PiB-equivocal, and C-11-PiB-negative groups. The ratio of gray matter uptake to white matter retention was lower in the BP images than static images from the C-11-PiB-negative and C-11-PiB-equivocal groups, whereas it was higher in the C-11-PiB-positive group. Conclusion: C-11-PiB PET BP images can clarify visual interpretation of clinical static C-11-PiB-equivocal images by reducing the interference of nonspecific white matter retention. We conclude that C-11-PiB-equivocal PET findings on static images reflect cortical amyloid deposits, which can be verified using BP images. Furthermore, quantitative assessments, such as SUVR and nondisplaceable BP, are of no use for correctly rating equivocal visual findings.
  • SungWoon Im; Ryuichiro Ashikaga; Yukinobu Yagyu; Tetsuya Wakayama; Mitsuharu Miyoshi; Tomoko Hyodo; Izumi Imaoka; Seishi Kumano; Kazunari Ishii; Takamichi Murakami
    European Radiology Springer Science and Business Media LLC 25 (11) 3175 - 3186 0938-7994 2015/11 [Refereed]
  • PiB陰性例の18F-FDG PETによる脳代謝分布の検討
    細川 知紗; 石井 一成; 若林 雄一; 兵頭 朋子; 花田 一志; 甲斐田 勇人; 細野 眞; 木村 裕一; 村上 卓道
    核医学 (一社)日本核医学会 52 (3) 262 - 262 0022-7854 2015/09
  • Yuichi Wakabayashi; Kazunari Ishii; Chisa Hosokawa; Tomoko Hyodo; Takenori Kozuka; Takamichi Murakami; Kazuro Sugimura
    JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 56 (3) 0161-5505 2015/05
  • Gen Koiwahara; Takaharu Tsuda; Megumi Matsuda; Masaaki Hirata; Hiroaki Tanaka; Tomoko Hyodo; Teruhito Kido; Teruhito Mochizuki
    Japanese journal of radiology 33 (4) 194 - 200 2015/04 
    PURPOSE: The purpose of this study was to characterize hepatic parenchymal enhancement for normal and diseased liver in dynamic computed tomography (CT) with the dose of contrast medium calculated on the basis of body surface area (BSA). MATERIALS AND METHODS: The records of 328 consecutive patients who underwent triple-phase contrast-enhanced CT were retrospectively reviewed. The patients were divided into four groups: normal liver (n = 125), chronic hepatitis (CH) (n = 92), Child-Pugh grade A liver cirrhosis (LC-A) (n = 78), and Child-Pugh grade B liver cirrhosis (LC-B) (n = 33). All patients received 22 g I m(-2) as contrast material, calculated on the basis of BSA. CT values were measured in the region of interest during the pre-contrast, arterial, and portal phases, and the change in the CT value (ΔHU, where HU is Hounsfield units) compared with pre-contrast images was calculated. RESULTS: Mean ΔHU for the hepatic parenchyma for the normal liver, CH, LC-A, and LC-B groups during the portal phase was 55.5 ± 11.8 HU, 55.2 ± 12.5 HU, 50.0 ± 13.0 HU, and 43.0 ± 12.7 HU, respectively; generalized estimating equation analysis showed the differences were significant (p < 0.01). CONCLUSION: Hepatic parenchymal enhancement during the portal phase decreased as the severity of chronic liver damage increased.
  • Minori Onoda; Tomoko Hyodo; Takamichi Murakami; Masahiro Okada; Tatsuro Uto; Masatoshi Hori; Tosiaki Miyati
    EUROPEAN JOURNAL OF RADIOLOGY ELSEVIER IRELAND LTD 84 (3) 339 - 345 0720-048X 2015/03 [Refereed]
     
    Objective: To compare signal intensity (SI) correction using scale and rescale slopes with SI correction using SIs of spleen and muscle for quantifying multiphase hepatic contrast enhancement with Gd-EOB-DTPA by assessing their correlation with T-1 values generated from Look-Locker turbo-field-echo (LL-TFE) sequence data (ER-T-1). Materials and methods: Thirty patients underwent Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in this prospective clinical study. For each patient, breath-hold T-1-weighted fat-suppressed three-dimensional (3D) gradient echo sequences (e-THRIVE) were acquired before and 2 (first phase), 10 (second phase), and 20 min (third phase) after intravenous Gd-EOB-DTPA. Look-Locker turbo-fieldecho (LL-TFE) sequences were acquired before and 1.5 (first phase), 8 (second phase), and 18 min (third phase) postcontrast. The liver parenchyma enhancement ratios (ER) of each phase were calculated using the SI from e-THRIVE sequences (ER-SI) and the T-1 values generated from LL-TFE sequence data (ER-T-1) respectively. ER-SIs were calculated in three ways: (1) comparing with splenic SI (ER-SI-s), (2) comparing with muscle SI (ER-SI-m), (3) using scale and rescale slopes obtained from DICOM headers (ER-SI-c), to eliminate the effects of receiver gain and scaling. For each of the first, second and third phases, correlation and agreement were assessed between each ER-SI and ER-T-1. Results: In the first phase, all ER-SIs correlated weakly with ER-Ti. In the second and third phases, ER-SI-c showed a stronger linear correlation with ER-Ti (r(2) =0.71-0.72, p <0.01) than did ER-SI-s (r(2) =0.37-0.39, p <0.01) or ER-SI-m (r(2) =0.30-0.41, p <0.01). Conclusion: SI correction using scale and rescale slopes from DICOM data is the most acceptable algorithm for evaluating delayed-phase Gd-EOB-DTPA hepatic enhancement. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
  • Masahiro Okada; Takamichi Murakami; Norihisa Yada; Kazushi Numata; Minori Onoda; Tomoko Hyodo; Tatsuo Inoue; Kazunari Ishii; Masatoshi Kudo
    JOURNAL OF MAGNETIC RESONANCE IMAGING WILEY-BLACKWELL 41 (2) 329 - 338 1053-1807 2015/02 [Refereed]
     
    PurposeTo compare four imaging approaches in cirrhotic estimation; pre-enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal-based liver-to-muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography. Materials and MethodsConsecutive 58 patients with chronic liver diseases who underwent both Gd-EOB-DTPA-enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis. ResultsRR was found to be inversely correlated with LSM (r=-0.65). RR decreased with degree of fibrosis (F0-F1, 58.56.2%, versus F2-F3-F4, 48.8 +/- 11.7%, P=0.010, F0-F1-F2, 58.2 +/- 6.2% versus F3-F4, 45.5 +/- 12.3%, P=0.010 and F0-F1, 58.5 +/- 6.2%, versus F2-F3, 52.1 +/- 12.0%, P=0.0038). LSM increased with degree of fibrosis (F0-F1, 5.4 +/- 2.2 kPa versus F2-F3-F3, 19.3 +/- 15.5 kPa, P=0.0011 and F0-F1-F2, 6.8 +/- 3.6 kPa versus F3-F4, 23.8 +/- 17.1 kPa, P=0.0029 and F0-F1, 5.4 +/- 2.2 kPa, versus F2-F3, 11.4 +/- 7.2 kPa, P=0.0098). Area under ROC curves were 0.83 (F3-F4), 0.72 (F2-F3-F4), 0.68 (F2-F3) for RR and 0.83 (F3-F4), 0.88 (F2-F3-F4), 0.81 (F2-F3) for LSM in discriminating between patients with fibrosis. ConclusionThe capability by LSM was better than those by RR of T1RT, pre-enhancement T1RT, and L/M ratio to differentiate F2, but LSM and RR of T1RT showed the same value to differentiate F3. J. Magn. Reson. Imaging 2015;41:329-338.(c) 2013 Wiley Periodicals, Inc.
  • Chisa Hosokawa; Kazunari Ishii; Tomoko Hyodo; Kenta Sakaguchi; Kimio Usami; Kenji Shimamoto; Yuzuru Yamazoe; Makoto Hosono; Kazushi Hanada; Masami Ueda; Kazuma Saigo; Takamichi Murakami
    ANNALS OF NUCLEAR MEDICINE SPRINGER 29 (2) 164 - 169 0914-7187 2015/02 [Refereed]
     
    We have encountered occasional equivocal findings when assessing cerebral cortical amyloid retention with C-11-Pittsburgh compound B (PiB) PET. We investigated the diagnostic significance of equivocal PiB PET findings. This retrospective study included 101 consecutive patients complaining of cognitive disorders (30 Alzheimer's disease, 25 mild cognitive impairment, 8 Lewy body disease, 7 frontotemporal lobar degeneration, 31 others) who underwent both C-11-PiB PET and F-18-fluorodeoxy-d-glucose (FDG) PET. We visually classified PiB-positive, PiB-equivocal or PiB-negative ratings according to cortical uptake. For quantitative assessments of PiB PET, standard uptake values referred to cerebellar cortex (SUVR) were calculated in regional template volume of interests (frontal, temporoparietal, precuneus/posterior cingulate cortex, cerebral white matter and cerebellar cortex). The results of visual assessment were compared with the regional and mean cortical SUVRs and cortical-to-white matter ratio of PiB uptake, as well as clinical and FDG PET findings. Among the 101 scans, 41 were PiB negative, 11 were PiB equivocal, and 49 were rated PiB positive in the visual assessments. The mean cortical SUVR and cortical-to-white matter ratio were 0.97 +/- A 0.07 and 0.57 +/- A 0.21 in PiB-negative, 1.51 +/- A 0.17 and 0.75 +/- A 0.06 in PiB equivocal and 2.10 +/- A 0.33 and 0.97 +/- A 0.11 in PiB-positive group, respectively. Nine of 11 subjects with PiB-equivocal findings had cognitive impairments and FDG distribution compatible with Alzheimer's disease or dementia with Lewy bodies. We considered equivocal visual findings on PiB PET equivalent to PiB-positive with slight cortical uptake. In addition, slight cortical amyloid deposits were considered to cause cerebral metabolic abnormality and cognitive impairment. Although mean cortical SUVR was more sensitive than visual assessment because of low cortical-to-white matter contrast due to non-specific accumulation in white matter, it is important not to overlook small amounts of cortical uptake of PiB in visual inspection for exact diagnosis.
  • Kazunari Ishii; Chisa Hosokawa; Tomoko Hyodo; Kenta Sakaguchi; Kimio Usami; Kenji Shimamoto; Makoto Hosono; Yuzuru Yamazoe; Takamichi Murakami
    ANNALS OF NUCLEAR MEDICINE SPRINGER 29 (1) 78 - 83 0914-7187 2015/01 [Refereed]
     
    There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition. The aim of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the DLB brain and measure the degree of regional hypometabolism. Ten consecutive subjects with DLB and 10 AD patients who underwent both Pittsburgh compound B (PiB)-PET and F-18-fluoro-2-deoxyglucose (FDG)-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG- and PiB-PET images. All AD patients and five DLB patients showed amyloid deposits (PiB positive). In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups. There were no differences in regional glucose metabolism between PiB positive and negative DLB patients. In the DLB brain, it is suggested that decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area and the degree of parietotemporal and occipital hypometabolism in DLB brain is much larger than that in AD brain.
  • 若林 雄一; 石井 一成; 河内 崇; 細川 知紗; 山川 美帆; 兵頭 朋子; 任 誠雲; 鶴崎 正勝; 足利 竜一郎; 松木 充; 細野 眞; 北村 登; 村上 卓道
    核医学 (一社)日本核医学会 51 (4) 438 - 439 0022-7854 2014/11
  • 軽症アルツハイマー病の18F-FDG PETと11C-PiB PET検査の経時的画像変化の検討
    細川 知紗; 石井 一成; 兵頭 朋子; 坂口 健太; 宇佐美 公男; 若林 雄一; 鶴崎 正勝; 松木 充; 細野 眞; 村上 卓道
    核医学 (一社)日本核医学会 51 (3) 284 - 284 0022-7854 2014/09
  • Masahiro Okada; Tetsuya Wakayama; Norihisa Yada; Tomoko Hyodo; Kazushi Numata; Yuki Kagawa; Daisuke Nishiyama; Keizo Miyakoshi; Takamichi Murakami
    ABDOMINAL IMAGING SPRINGER 39 (4) 694 - 701 0942-8925 2014/08 [Refereed]
     
    To investigate optimal flip angle (FA) of three-dimensional fat-suppressed T1-weighted image on Gd-EOB-DTPA-enhanced MRI. Forty-five patients with 35 hepatocellular carcinomas (HCCs) and 16 liver metastases (METs) were investigated. Signal-to-noise ratio (SNR), tumor-to-liver contrast (TLC) of HCC and MET, visual image quality (IQ) and lesion conspicuity (LeCo) were evaluated at hepatobiliary phase with different FAs (FA15A degrees-30A degrees-45A degrees-60A degrees in 13 patients, FA5A degrees-10A degrees-15A degrees-20A degrees-25A degrees in 32 patients). TLC gradually showed better in range from FA15A degrees to FA60A degrees and FA5A degrees to FA25A degrees, but SNRs gradually decreased. SNR and TLC-MET at FA15A degrees were significantly better than those at FA45A degrees and FA60A degrees. SNR at FA10A degrees was significantly higher than at FA5A degrees, FA20A degrees, and FA25A degrees. TLC-HCC and TLC-MET at FA5A degrees were inferior to other FAs. IQs and LeCos at FA15A degrees and FA30A degrees were superior to those at FA45A degrees and FA60A degrees. IQs at FA5A degrees and FA25A degrees were significantly lower than those at FA10A degrees-20A degrees, although LeCos for HCC and MET at FA25A degrees were superior to those at FA5A degrees-20A degrees. FA ranging from 10A degrees to 20A degrees is suitable for hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI, to image HCC and MET.
  • Takamichi Murakami; Tomoko Hyodo; Masakatsu Tsurusaki; Yasuharu Imai
    Journal of Hepatocellular Carcinoma Informa UK Limited 101 - 101 2014/07 [Refereed]
  • 岡田 真広; 兵頭 朋子; 矢田 典久; 安座間 喜明; 伊良波 裕子; 村山 貞之; 工藤 正俊; 村上 卓道
    画像診断 学研メディカル秀潤社 34 (7) 753 - 759 0285-0524 2014/05
  • H. Takahashi; K. Ishii; C. Hosokawa; T. Hyodo; N. Kashiwagi; M. Matsuki; R. Ashikaga; T. Murakami
    AMERICAN JOURNAL OF NEURORADIOLOGY AMER SOC NEURORADIOLOGY 35 (5) 906 - 911 0195-6108 2014/05 [Refereed]
     
    BACKGROUND AND PURPOSE: Alzheimer disease is the most common neurodegenerative disorder with dementia, and a practical and economic biomarker for diagnosis of Alzheimer disease is needed. Three-dimensional arterial spin-labeling, with its high signal-to-noise ratio, enables measurement of cerebral blood flow precisely without any extrinsic tracers. We evaluated the performance of 3D arterial spin-labeling compared with SPECT, and demonstrated the 3D arterial spin-labeled imaging characteristics in the diagnosis of Alzheimer disease. MATERIALS AND METHODS: This study included 68 patients with clinically suspected Alzheimer disease who underwent both 3D arterial spin-labeling and SPECT imaging. Two readers independently assessed both images. Kendall W coefficients of concordance (K) were computed, and receiver operating characteristic analyses were performed for each reader. The differences between the images in regional perfusion distribution were evaluated by means of statistical parametric mapping, and the incidence of hypoperfusion of the cerebral watershed area, referred to as "borderzone sign" in the 3D arterial spin-labeled images, was determined. RESULTS: Readers showed K = 0.82/0.73 for SPECT/3D arterial spin-labeled imaging, and the respective areas under the receiver operating characteristic curve were 0.82/0.69 for reader 1 and 0.80/0.69 for reader 2. Statistical parametric mapping showed that the perisylvian and medial parieto-occipital perfusion in the arterial spin-labeled images was significantly higher than that in the SPECT images. Borderzone sign was observed on 3D arterial spin-labeling in 70% of patients misdiagnosed with Alzheimer disease. CONCLUSIONS: The diagnostic performance of 3D arterial spin-labeling and SPECT for Alzheimer disease was almost equivalent. Three-dimensional arterial spin-labeled imaging was more influenced by hemodynamic factors than was SPECT imaging.
  • Hiroto Takahashi; Masahiro Okada; Tomoko Hyodo; Syojiro Hidaka; Yuki Kagawa; Mitsuru Matsuki; Masakatsu Tsurusaki; Takamichi Murakami
    EUROPEAN JOURNAL OF RADIOLOGY ELSEVIER IRELAND LTD 83 (4) 684 - 691 0720-048X 2014/04 [Refereed]
     
    Purpose: To investigate whether low-dose dynamic CT of the liver with iterative reconstruction can reduce both the radiation dose and the amount of contrast medium. Materials and methods: This study was approved by our institutional review board. 113 patients were randomly assigned to one of two groups. Group A/group B (fifty-eight/fifty-five patients) underwent liver dynamic CT at 120/100 kV, with 0/40% adaptive statistical iterative reconstruction (ASIR), with a contrast dose of 600/480 mg I/kg, respectively. Radiation exposure was estimated based on the manufacturer's phantom data. The enhancement value of the hepatic parenchyma, vessels and the tumor-to-liver contrast of hepatocellular carcinomas (HCCs) were compared between two groups. Two readers independently assessed the CT images of the hepatic parenchyma and HCCs. Results: The mean CT dose indices: 6.38/4.04 mGy, the dose-length products: 194.54/124.57 mGy cm, for group A/group B. The mean enhancement value of the hepatic parenchyma and the tumor-to-liver contrast of HCCs with diameters greater than 1 cm in the post-contrast all phases did not differ significantly between two groups (P > 0.05). The enhancement values of vessels in group B were significantly higher than that in group A in the delayed phases (P < 0.05). Two reader's confidence levels for the hepatic parenchyma in the delayed phases and HCCs did not differ significantly between the groups (P > 0.05). Conclusions: Low-dose dynamic CT with ASIR can reduce both the radiation dose and the amount of contrast medium without image quality degradation, compared to conventional dynamic CT without ASIR. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
  • Ken Kamata; Masayuki Kitano; Masatoshi Kudo; Hiroki Sakamoto; Kumpei Kadosaka; Takeshi Miyata; Hajime Imai; Kiyoshi Maekawa; Takaaki Chikugo; Masashi Kumano; Tomoko Hyodo; Takamichi Murakami; Yasutaka Chiba; Yoshifumi Takeyama
    ENDOSCOPY GEORG THIEME VERLAG KG 46 (4) 358 - 358 0013-726X 2014/04
  • 腫瘤形成した慢性唾液腺炎のFDG-PET/CT所見
    細川 知紗; 柏木 伸夫; 松久保 祐子; 山田 穣; 任 誠雲; 兵頭 朋子; 高橋 洋人; 柳生 行伸; 岡田 真広; 小塚 健倫; 今岡 いずみ; 鶴崎 正勝; 松木 充; 足利 竜一郎; 細野 眞; 石井 一成; 村上 卓道; 筑後 雅章
    Japanese Journal of Radiology (公社)日本医学放射線学会 32 (Suppl.) 45 - 45 1867-1071 2014/02
  • Ken Kamata; Masayuki Kitano; Masatoshi Kudo; Hiroki Sakamoto; Kumpei Kadosaka; Takeshi Miyata; Hajime Imai; Kiyoshi Maekawa; Takaaki Chikugo; Masashi Kumano; Tomoko Hyodo; Takamichi Murakami; Yasutaka Chiba; Yoshifumi Takeyama
    ENDOSCOPY GEORG THIEME VERLAG KG 46 (1) 22 - 29 0013-726X 2014/01 [Refereed]
     
    Background and study aims: Pancreatic ductal adenocarcinomas (PDAC) sometimes arise in patients with intraductal papillary mucinous neoplasms (IPMNs). This study examined the incidence of PDACs concomitant to or derived from branch duct IPMNs. The usefulness of endoscopic ultrasonography (EUS) relative to other imaging methods for detecting these tumors was also assessed. Patients and methods: This retrospective study used data from clinical records and imaging studies that were collected prospectively. During 2001-2009, 167 consecutive patients with IPMNs underwent EUS, ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). The 102 patients whose branch duct IPMNs lacked mural nodules/symptoms and thus did not qualify for resection were followed up by semiannual EUS and annual ultrasonography, CT, and MRI. The sensitivity and specificity with which the four modalities detected IPMN-derived and -concomitant PDACs at the first examination and throughout the study period were evaluated. The rate of PDAC development during follow-up was analyzed by the Kaplan-Meier method. Results: A total of 17 IPMN-derived and 11 IPMN-concomitant PDACs were diagnosed at the first examination. Lesions that did not qualify for resection or chemotherapy were followed up for a median of 42 months. Seven IPMN-concomitant PDACs and no IPMN-derived PDACs were detected during follow-up. The 3- and 5-year rates of IPMN-concomitant PDAC development were 4.0% and 8.8%, respectively. At the first examination, EUS was superior to other imaging modalities in terms of IPMN-derived and -concomitant PDAC detection. Throughout the study period, including follow-up, EUS was significantly better at detecting IPMN-concomitant PDACs than the other modalities. Conclusions: IPMN-concomitant PDACs are quite often found at diagnosis and during follow-up.EUS examination of the whole pancreas plays an important role in the management of IPMNs as it allows the early detection of these small invasive carcinomas.
  • Ken Kamata; Masayuki Kitano; Masatoshi Kudo; Hiroki Sakamoto; Kumpei Kadosaka; Takeshi Miyata; Hajime Imai; Kiyoshi Maekawa; Takaaki Chikugo; Masashi Kumano; Tomoko Hyodo; Takamichi Murakami; Yasutaka Chiba; Yoshifumi Takeyama
    Endoscopy Georg Thieme Verlag 46 (4) 358  1438-8812 2014 [Refereed]
  • Yuko Matsukubo; Nobuo Kashiwagi; Masanobu Uemura; Sachiyo Tatsumi; Hiroto Takahashi; Tomoko Hyodo; Noriyuki Tomiyama; Ryuichiro Ashikaga; Kazunari Ishii; Takamichi Murakami
    Neuroradiology 11 55 (11) 1341 - 1344 0028-3940 2013/11 [Refereed]
     
    Introduction: The aim of this study was to investigate the prevalence of intravertebral pneumatocyst (IVP) of the cervical spine by age group, compared with that of intradiscal vacuum (IDV). Methods: We investigated 500 consecutive patients who underwent cervical computed tomography (CT) from May 2012 to May2013 for various indications. CT datasets were assessed for the presence of IVPs and IDVs with stratification by age. Results: IVPs of the cervical spine were detected in 8 % (7 of 86 subjects) of patients in their forties or below, 30 % (23 of 75) in their fifties, 49 % (67 of 136) in their sixties, 55 % (76 of 137) in their seventies, and 60 % (40 of 66) in their eighties or over. IDVs of the cervical spine were detected in 6, 25, 48, 54, and 57 %, respectively. Coexistence of both phenomena was identified in 4, 17, 33, 40, and 43 %, respectively. Conclusion: IVPs of the cervical spine are a common incidental finding, increasing in prevalence with age and more common than IDV in all age groups. © 2013 Springer-Verlag Berlin Heidelberg.
  • Tomoko Hyodo; Takamichi Murakami; Yasuharu Imai; Masahiro Okada; Masatoshi Hori; Yuki Kagawa; Sachiyo Kogita; Seishi Kumano; Masatoshi Kudo; Teruhito Mochizuki
    Radiology Radiological Society of North America (RSNA) 266 (2) 480 - 490 0033-8419 2013/02 [Refereed]
  • Dual-energy CTによる肝脂肪定量 ファントム実験によるsingle-energy CTおよびMRSとの比較
    兵頭 朋子; 岡田 真広; 工藤 正幸; 鶴崎 正勝; 足利 竜一朗; 石井 一成; 村上 卓道
    日本医学放射線学会学術集会抄録集 (公社)日本医学放射線学会 72回 S251 - S251 0048-0428 2013/02
  • Tatsuo Inoue; Tomoko Hyodo; Takamichi Murakami; Yukihisa Takayama; Akihiro Nishie; Atsushi Higaki; Keiko Korenaga; Azusa Sakamoto; Yukio Osaki; Hiroshi Aikata; Kazuaki Chayama; Takeshi Suda; Toru Takano; Kennichi Miyoshi; Masahiko Koda; Kazushi Numata; Hironori Tanaka; Hiroko Iijima; Hironori Ochi; Masashi Hirooka; Yasuharu Imai; Masatoshi Kudo
    Digestive Diseases S. Karger AG 31 (5-6) 472 - 479 1421-9875 2013 [Refereed]
     
    Objective: We aimed to investigate the natural outcome of nonhypervascular lesions detected in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI by performing a longitudinal study retrospectively enrolled in a nationwide manner. Methods: Between February 2008 and March 2011, 224 patients with 504 nodules that were diagnosed as nonhypervascular by imaging were recruited from institutions that participated in the present study. We examined the natural outcome of nonhypervascular lesions and evaluated the risk factors. Results: Of the 504 nodules, 173 (34.3%) showed hypervascular transformation. The overall cumulative incidence of hypervascular transformation was 14.9% at 12 months and 45.8% at 24 months. Multivariate analysis using the Cox regression model revealed previous treatment history for hepatocellular carcinoma (HCC relative risk = 1.498 p = 0.036, 95% CI 1.03-2.19) and hyperintensity on T2-weighted images (relative risk = 1.724 p = 0.015, 95% CI 1.11-2.67) were identified as independent factors for hypervascular transformation. Conclusions: Patients who have a previous treatment history for HCC and with hypointense nodules showing hyperintensity on T2-weighted images need careful follow-up because of the high incidence of hypervascular transformation.
  • Tetsuya Fujigai; Seishi Kumano; Masahiro Okada; Tomoko Hyodo; Izumi Imaoka; Yukinobu Yagyu; Ryuichiro Ashikaga; Kazunari Ishii; Takamichi Murakami
    EUROPEAN JOURNAL OF RADIOLOGY ELSEVIER IRELAND LTD 81 (11) 2978 - 2983 0720-048X 2012/11 [Refereed]
     
    Purpose: The purpose of this study is to prospectively investigate the optimal dose of contrast medium for the depiction of hypervascular hepatocellular carcinoma (HCC) during the hepatic arterial phase (HAP), portal venous phase (PVP) and delayed phase (DP) of dynamic MDCT. Materials and methods: The study included 128 patients, out of these patients, 36 patients were found to have 56 hypervascular HCCs. Sixty-three patients were assigned to receive a dose of 525 mgI/kg with protocol A, and 62 received a dose of 630 mgI/kg with protocol B. Measurements of the attenuation values of the abdominal aorta, portal vein, hepatic vein, hepatic parenchyma and HCC during the HAP, PVP and DP were taken. Tumor-liver contrast (TLC) was calculated from the attenuation value of the hepatic parenchyma and HCC. Results: The aortic attenuation value with protocol B (351, 166, and 132 HU) was significantly higher than that with protocol A (313, 153, and 120 HU) during all the phases, (P < 0.01 for all phases). The hepatic enhancement from unenhanced baseline with protocol B (25.2, 63.6, 50.6 HU) was significantly higher than that with protocol A (20.2, 55.1 and 43.0 HU) during all the phases, (P < 0.01 for all phases). The TLC with protocol B (37.4, -11.8 and -13.6 HU) was significantly higher than that with protocol A (28.0, -9.8 and -12.1 HU) during HAP (P = 0.042). Conclusion: The administration of 630 mgI/kg of body weight depicts hypervascular HCC more clearly during HAP and shows sufficient hepatic enhancement of 50 HU during DP. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
  • K. Kamata; M. Kitano; M. Kudo; H. Sakamoto; K. Kadosaka; T. Miyata; H. Imai; T. Komaki; K. Maekawa; T. Chikugo; M. Kumano; T. Hyodo; T. Murakami; Y. Takeyama
    PANCREAS LIPPINCOTT WILLIAMS & WILKINS 41 (7) 1143 - 1143 0885-3177 2012/10
  • Tatsuo Inoue; Masatoshi Kudo; Mina Komuta; Sosuke Hayaishi; Taisuke Ueda; Masahiro Takita; Satoshi Kitai; Kinuyo Hatanaka; Norihisa Yada; Satoru Hagiwara; Hobyung Chung; Toshiharu Sakurai; Kazuomi Ueshima; Michiie Sakamoto; Osamu Maenishi; Tomoko Hyodo; Masahiro Okada; Seishi Kumano; Takamichi Murakami
    JOURNAL OF GASTROENTEROLOGY SPRINGER JAPAN KK 47 (9) 1036 - 1047 0944-1174 2012/09 [Refereed]
     
    We aimed to evaluate gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the detection of hepatocellular carcinomas (HCCs) and dysplastic nodules (DNs) compared with dynamic multi-detector row computed tomography (MDCT), and to discriminate between HCCs and DNs. Eighty-six nodules diagnosed as HCC or DNs were retrospectively investigated. Gd-EOB-DTPA-enhanced MRI and dynamic MDCT were compared with respect to their diagnostic ability for hypervascular HCCs and detection sensitivity for hypovascular tumors. The ability of hepatobiliary images of Gd-EOB-DTPA-enhanced MRI to discriminate between these nodules was assessed. We also calculated the EOB enhancement ratio of the tumors. For hypervascular HCCs, the diagnostic ability of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of MDCT for tumors less than 2 cm (p = 0.048). There was no difference in the detection of hypervascular HCCs between hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI (43/45: 96%) and dynamic MDCT (40/45: 89%), whereas the detection sensitivity of hypovascular tumors by Gd-EOB-DTPA-enhanced MRI was significantly higher than that by dynamic MDCT (39/41: 95% vs. 25/41: 61%, p = 0.001). EOB enhancement ratios were decreased in parallel with the degree of differentiation in DNs and HCCs, although there was no difference between DNs and hypovascular well-differentiated HCCs. The diagnostic ability of Gd-EOB-DTPA-enhanced MRI for hypervascular HCCs less than 2 cm was significantly higher than that of MDCT. For hypovascular tumors, the detection sensitivity of hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was significantly higher than that of dynamic Gd-EOB-DTPA-enhanced MRI and dynamic MDCT. It was difficult to distinguish between DNs and hypovascular well-differentiated HCCs based on the EOB enhancement ratio.
  • 兵頭 朋子; 岡田 真広; 矢田 典久; 前西 修; 香川 祐毅; 任 誠雲; 柏木 伸夫; 柳生 行伸; 今岡 いずみ; 松木 充; 足利 竜一朗; 石井 一成; 工藤 正俊; 村上 卓道
    近畿大学医学雑誌 近畿大学医学会 37 (3-4) 18A - 18A 0385-8367 2012/09
  • T. Hyodo; S. Kumano; F. Kushihata; M. Okada; M. Hirata; T. Tsuda; Y. Takada; T. Mochizuki; T. Murakami
    BRITISH JOURNAL OF RADIOLOGY BRITISH INST RADIOLOGY 85 (1015) 887 - 896 0007-1285 2012/07 [Refereed]
     
    Recent developments in imaging technology have enabled CT and MR cholangiopancreatography (MRCP) to provide minimally invasive alternatives to endoscopic retrograde cholangiopancreatography for the pre- and post-operative assessment of biliary disease. This article describes anatomical variants of the biliary tree with surgical significance, followed by comparison of CT and MR cholangiographies. Drip infusion cholangiography with CT (DIC-CT) enables high-resolution three-dimensional anatomical representation of very small bile ducts (e. g. aberrant branches, the caudate branch and the cystic duct), which are potential causes of surgical complications. The disadvantages of DIC-CT include the possibility of adverse reactions to biliary contrast media and insufficient depiction of bile ducts caused by liver dysfunction or obstructive jaundice. Conventional MRCP is a standard, non-invasive method for evaluating the biliary tree. MRCP provides useful information, especially regarding the extrahepatic bile ducts and dilated intrahepatic bile ducts. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MRCP may facilitate the evaluation of biliary structure and excretory function. Understanding the characteristics of each type of cholangiography is important to ensure sufficient perioperative evaluation of the biliary system.
  • Masahiro Okada; Kazunari Ishii; Kazushi Numata; Tomoko Hyodo; Seishi Kumano; Masayuki Kitano; Masatoshi Kudo; Takamichi Murakami
    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL ZHEJIANG UNIV SCH MEDICINE 11 (3) 307 - 313 1499-3872 2012/06 [Refereed]
     
    BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child-Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1-weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin >= 1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffes post-hoc test after two-way repeated-measures ANOVA and Pearson's correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes, significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio. CONCLUSIONS: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB-DTPA.
  • T. Hyodo; Y. Sugawara; K. Sakayama; K. Kito
    BRITISH JOURNAL OF RADIOLOGY BRITISH INST RADIOLOGY 85 (1010) E26 - E30 0007-1285 2012/02 [Refereed]
     
    We report a case of early-stage malignant peripheral nerve sheath tumour (MPNST) found in a solitary neurofibroma, and its CT and MRI findings. A 19-year-old male with no known history of a neurofibromatosis presented with a painless swelling in the left forearm. CT and MRI scans showed a well-circumscribed, intermuscular mass, which was 6.0 cm in diameter and contained a strongly enhanced 1.0 cm nodular structure with surrounding oedema. Peripheral nerve continuity with the mass was not seen. Histological evaluation proved the nodular structure was an MPNST component completely surrounded by neurofibroma. Following an excisional biopsy with wide margins, the patient was followed up for a year without treatment and no recurrence was observed.
  • Dual energy CTを用いた肝脂肪の定量評価 ファントム実験と初期臨床経験
    兵頭 朋子; 岡田 真広; 矢田 典久; 工藤 正幸; 香川 祐毅; 熊野 正士; 石井 一成; 工藤 正俊; 村上 卓道
    日本医学放射線学会学術集会抄録集 (公社)日本医学放射線学会 71回 S272 - S272 0048-0428 2012/02
  • ASIRを用いた低電圧肝Dynamic-CTによる被曝低減と造影剤量低減に関する報告
    日高 正二朗; 高橋 洋人; 岡田 真広; 兵頭 朋子; 香川 祐毅; 今岡 いずみ; 石井 一成; 足利 竜一朗; 工藤 正俊; 村上 卓道
    日本医学放射線学会学術集会抄録集 (公社)日本医学放射線学会 71回 S273 - S273 0048-0428 2012/02
  • Takamichi Murakami; Masahiro Okada; Tomoko Hyodo
    MAGNETIC RESONANCE IN MEDICAL SCIENCES JPN SOC MAGNETIC RESONANCE IN MEDICINE 11 (2) 75 - 81 1347-3182 2012 
    Detection, characterization, staging, and treatment monitoring are major roles of diagnostic imaging of liver cancers. Developments in multidetector-row computed tomography (MDCT) technology have increased the spatial and temporal resolution of CT to allow more precise evaluation of the hemodynamics of liver tumors and improve the diagnostic accuracy of dynamic MDCT. The high spatial and temporal resolutions of dynamic MDCT enable us to reconstruct 3-dimensional (3D) images that are very useful for pretreatment evaluation. Dynamic MR imaging with fast 3D T-1-weighted gradient echo imaging sequence using nonspecific contrast medium can be highly sensitive for detecting hypervascular HCC. However, the use of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), a contrast medium specific to hepatic tissue, offers greater diagnostic ability and, so, has become essential to liver imaging. MR imaging with Gd-EOB-DTPA may replace CT during hepatic arteriography and CT during arterioportography.
  • Takamichi Murakami; Masahiro Okada; Tomoko Hyodo
    Magnetic Resonance in Medical Sciences 2 11 (2) 75 - 81 1347-3182 2012 [Refereed]
     
    Detection, characterization, staging, and treatment monitoring are major roles of diagnostic imaging of liver cancers. Developments in multidetector-row computed tomography (MDCT) technology have increased the spatial and temporal resolution of CT to allow more precise evaluation of the hemodynamics of liver tumors and improve the diagnostic accuracy of dynamic MDCT. The high spatial and temporal resolutions of dynamic MDCT enable us to reconstruct 3-dimensional (3D) images that are very useful for pretreatment evaluation. Dynamic MR imaging with fast 3D T1-weighted gradient echo imaging sequence using nonspecific contrast medium can be highly sensitive for detecting hypervascu-lar HCC. However, the use of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), a contrast medium specific to hepatic tissue, offers greater diagnostic ability and, so, has become essential to liver imaging. MR imaging with Gd-EOB-DTPA may replace CT during hepatic arteriography and CT during arterioportography.
  • 兵頭 朋子; 岡田 真広; 香川 祐毅; 熊野 正士; 任 誠雲; 柏木 伸夫; 柳生 行伸; 今岡 いずみ; 足利 竜一朗; 石井 一成; 工藤 正俊; 村上 卓道
    近畿大学医学雑誌 近畿大学医学会 36 (3-4) 13A - 13A 0385-8367 2011/12
  • Gd-EOB-DTPA造影MRI肝細胞相で検出された慢性障害肝の乏血性結節 多血化の危険因子
    兵頭 朋子; 岡田 真広; 香川 祐毅; 熊野 正士; 堀 雅敏; 石井 一成; 今井 康陽; 望月 輝一; 工藤 正俊; 村上 卓道
    日本医学放射線学会学術集会抄録集 (公社)日本医学放射線学会 70回 S342 - S343 0048-0428 2011/02
  • Alshimaa Alaboudy; Tatsuo Inoue; Kinuyo Hatanaka; Hobyung Chung; Tomoko Hyodo; Seishi Kumano; Takamichi Murakami; Ehab Fawzy Abdou Moustafa; Masatoshi Kudo
    ONCOLOGY KARGER 81 66 - 72 0030-2414 2011 [Refereed]
     
    Objective: To clarify the diagnostic ability of combining imaging methods to diagnose hepatocellular carcinoma (HCC) using Sonazoid (R)-enhanced ultrasound (US), gadolinium diethylene-triamine-pentaacetic acid-enhanced (Gd-EOB-DTPA) magnetic resonance imaging (MRI), and contrast-enhanced computed tomography (CECT). Methods: A total of 32 patients who underwent surgical resection for HCC were studied. Sonazoid-enhanced US, Gd-EOB-DTPA MRI, CECT, and intraoperative contrast-enhanced ultrasonography were done for all patients. The definitive diagnosis of HCC in those patients was based on histopathological confirmation. Results: A total of 50 histologically proven HCCs were obtained from 32 patients; their mean (+/-SD) age was 68.3 years +/-8.1. The mean (+/-SD) nodule size was 2.6 cm +/- 1.9. Twenty percent were well-differentiated HCC, 64% were moderately differentiated HCC, 10% were poorly differentiated HCC, 4% were combined HCC and CCC, and 2% were HCC with severe necrosis. The overall diagnostic sensitivity of CEUS, CECT, and Gd-EOB-DTPA MRI was 72, 74, and 86%, respectively; however, there was no significant difference between the three imaging modalities in diagnosing typical HCC (p = 0.092). When combining the diagnostic ability of the different imaging modalities, the diagnostic sensitivity of Sonazoid-enhanced US and Gd-EOB-DTPA MRI was 90%, while addition of Sonazoid-enhanced US to CECT and CECT to Gd-EOB-DTPA MRI had a sensitivity of 82 and 88%, respectively. There was no significant difference between the three imaging combinations (p = 0.970). Conclusion: Sonazoid-enhanced US and Gd-EOB-DTPA MRI can be confidently used in daily clinical practice for the management of HCC. Copyright (C) 2011 S. Karger AG, Basel
  • Takamichi Murakami; Yasuharu Imai; Masahiro Okada; Tomoko Hyodo; Won-Jae Lee; Myeong-Jin Kim; Tonsok Kim; Byung Ihn Choi
    ONCOLOGY KARGER 81 86 - 99 0030-2414 2011 [Refereed]
     
    Detection, characterization, staging, and treatment monitoring are major roles in imaging diagnosis in liver cancers. Contrast-enhanced ultrasonography (CEUS) using micro-bubble contrast agents has expanded the role of US in the detection and diagnosis of liver nodules in patients at high risk of hepatocellular carcinoma (HCC). CEUS provides an accurate differentiation between benign and malignant liver nodules, which is critical for adequate management of HCC and is also useful for guidance of percutaneous local therapy of HCC and postprocedure monitoring of the therapeutic response. The technology of multidetector-row computed tomography (MDCT) has increased spatial and temporal resolutions of computed tomography (CT). It has made possible a more precise evaluation of the hemodynamics of liver tumor, and the diagnostic accuracy of dynamic MDCT has improved. Perfusion CT can measure tissue perfusion parameters quantitatively and can assess segmental hepatic function. Dynamic MDCT with high spatial and temporal resolution enables us to reconstruct 3- and 4-dimensional imaging, which is very useful for pretreatment evaluation. Dual-energy CT makes possible the differentiation of materials and tissues in images obtained based on the differences in iodine and water densities. Monochromatic images, which can be reconstructed by dual-energy CT data, provide some improvement in contrast and show a higher contrast-to-noise ratio for hypervascular HCCs. Dynamic magnetic resonance imaging with fast imaging sequence of 3-dimensional Fourier transformation T(1)-weighted gradient echo and nonspecific contrast medium can show high detection sensitivity of hypervascular HCC. However, the hepatic tissue-specific contrast medium, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid, has become an essential contrast medium for liver imaging because of its higher diagnostic ability. It may replace CT during hepatic arteriography and during arterioportography. Copyright (C) 2011 S. Karger AG, Basel
  • Tomoko Hyodo; Yoshifumi Sugawara; Takaharu Tsuda; Yutaka Yanagihara; Katsunori Aoki; Nozomu Tanji; Masaaki Hirata; Masateru Murakami; Masao Miyagawa; Masayoshi Yokoyama; Teruhito Mochizuki
    JAPANESE JOURNAL OF RADIOLOGY SPRINGER 27 (2) 111 - 114 1867-1071 2009/02 [Refereed]
     
    We present a case of sarcomatoid renal cell carcinoma (RCC). Although preoperative computed tomography (CT) scans demonstrated small lung and pleural nodules and mediastinal lymphadenopathy, these findings were not conclusive for metastases. Whole-body fluorine-18 fluorodeoxyglucose positron emission tomography and CT (FDG-PET/CT) performed 15 days after right nephrectomy showed intense FDG uptake in the aforementioned lesions (lung and pleural nodules, mediastinal lymph nodes). Unexpectedly, focal increased FDG uptake was found in the right infraspinatus muscle. FDG-PET/CT was considered useful for evaluating distant metastases and thus portending the aggressive nature of sarcomatoid RCC.

Books etc

  • “No Limit” CT Imaging
    Kazuo Awai; Seitaro Oda; Yoshinori Funama (ContributorLiver Fat Quantification. II Scan technique)MedicalView 2023/10 9784758321068 198-202
  • Japan Radiological Society (ContributorDigestive organs: Hepatocellular carcinoma)Kanehara Shuppan Co. Ltd 2021/09 9784307071239
  • Kazuo Awai (Contributorp2-7/p133-139)Medical View Co., Ltd. 2019/09 9784758316125 viii, 227p
  • Clinical Practice Guidelines for Hepatocellular Carcinoma 2017
    The Japan Society of Hepatology (Contributor)金原出版 2017/10 4307203739 264
  • Japan Radiological Society; Japanese College of Radiology (ContributorDigestive organs: Hepatocellular carcinoma)Kanehara Shuppan Co. Ltd 2016/09 4307071050 582
  • The Japan; Society of Hepatology; 日本肝臓学会 (Contributor)金原出版 2013/10 4307203186 223
  • Japan Radiological Society; 日本医学放射線学会; 日本放射線科専門医会; 医会 (Contributor)金原出版 2013/07 4307070933 480

Conference Activities & Talks

  • CT imaging for assessment of hepatic steatosis  [Not invited]
    Tomoko Hyodo; Masahiro Okada; Hiroyuki Morisaka; Shintaro Ichikawa; Satoshi Goshima
    The RSNA 109th Scientific Assembly and Annual Meeting  2023/11
  • CT and MR diagnosis of biliary tree and pancreatic duct  [Invited]
    Tomoko Hyodo
    Johoku Radiology Seminar  2023/09
  • Minoru Katsuki; Koji Abe; Hitoshi Habe; Tomoko Hyodo; Kazunari Ishii
    The 27th Student Convention of Kansai-Section of the Institute of Electronics, Information and Communication Engineers, Japan  2023/03  Osaka  一般社団法人 電子情報通信学会 関西支部学生会
  • MR cholangiopancreatography: Acquisition and interpretation  [Invited]
    Tomoko Hyodo
    The 25th Osaka-Kobe Abdominal & Interventional Radiology Conference  2022/12  Online
  • Acceleration Motion Compensation Diffusion-weighted Imaging For Aortitis: Phantom and Clinical Studies  [Not invited]
    Hyodo T; Nozaki Y; Kaida H; Morimoto-Ishikawa D; Ueda Y; Ito M; Yasuda N; Fukushima H; Yamamoto A; Ishii K
    The RSNA 108th Scientific Assembly and Annual Meeting  2022/11  Chicago
  • Quantitative Evaluation of Noncontrast Magnetic Resonance Enterography for Active Inflammation in Crohn's Disease Using Native T1 and T2Mapping  [Not invited]
    Morimoto-Ishikawa D; Hyodo T; Komeda Y; Fukushima H; Ito M; Ueda Y; Saito S; Ishii K
    The RSNA 108th Scientific Assembly and Annual Meeting  2022/11  Chicago
  • Acceleration Motion Compensation Diffusion-weighted Imaging for Large Vessel Vasculitis: Phantom Model and Initial Clinical Experience  [Not invited]
    Tomoko Hyodo; Daisuke Morimoto-Ishikawa; Hayato Kaida; Yu Ueda; Daisuke Tomita; Atsuhiro Yamamoto; Makoto Itoh; Nao Yasuda; Hiroyuki Fukushima; Yuji Nozaki; Itaru Matsumura; Kazunari Ishii
    The Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting  2022/05  London  International Society for Magnetic Resonance in Medicine
  • Daisuke Morimoto-Ishikawa; Tomoko Hyodo; Yoriaki Komeda; Hiroyuki Fukushima; Yu Ueda; Keizou Miyagoshi; Shigeyoshi Saito; Kazunari Ishii
    the Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting  2022/05  London  International Society for Magnetic Resonance in Medicine
  • Initial research on native T1 mapping focused on the detection of active ulcerative colitis  [Not invited]
    Daisuke Ishikawa; Tomoko Hyodo; Yoriaki Komeda; Yu Ueda; Keizo Miyagoshi; Shigeyoshi Saito; Kazunari Ishii
    The 78th Annual Meeting of the Japanese Society of Radiological Technology  2022/04
  • Initial experience of whole body MR imaging in the diagnosis of large vessel vasculitis  [Invited]
    Tomoko Hyodo
    Webinar on large vessel vasculitis  2022/02  Osaka
  • Acceleration Motion Compensation Diffusion-weighted Imaging for Diagnosis of Large Vessel Vasculitis  [Not invited]
    Miyuki Wakana; Tomoko Hyodo; Hayato Kaida; Kazunari Ishii; Daisuke Morimoto-Ishikawa; Makoto Ito; Nao Yasuda; Hiroyuki Fukushima; Daisuke Tomita; Atsuhiro Yamamoto; Yuji Nozaki; Itaru Matsumura
    The 330th Kansai Regional Meeting of the Japan Radiological Society  2022/02
  • Metastases to the Extraocular Muscles: MR Features of Institutional 16 Cases and a Systemic Review of Clinical Features  [Not invited]
    Nobuo Kashiwagi; Azusa Miura; Mio Sakai; Tomoko Hyodo; Chisato Matsuo; Masahiro Fujiwara; Atsuko Arisawa; Kazunari Ishii; Noriyuki Tomiyama
    The 107th Scientific Assembly & Annual Meeting of the Radiological Society of North America  2021/12  Chicago 
    *Teaching Points: Following a review of our institutional 16 patients with metastasis to the extraocular muscles which is the largest cohort to date, we present MR features with special attention to the number of lesions, shapes, margin characteristics, signal intensities on T1- and T2-weighted images, enhancement patterns. After a combination of patients from our institutions and from previous literature, we present clinical features including the primary tumor, presenting symptoms, affected muscles among the external ocular muscles, presence of metastasis to other organs, and presence of extra-orbital muscle metastases. *Table of Contents/Outline: 1. Summary of MR features in our 16 patients. 2. Summary of clinical features in 87 combined patients. 3. Presentation of illustrative cases. 4. Conclusions: MR features can be divided into two main patterns: a solitary and well-defined mass with the target appearance as an internal architecture and multi-muscular masses with an infiltrative nature. Regarding clinical features from the combined data, the most common primary tumors were breast cancer accounting for 30% of patients. The most common presenting symptom was proptosis and ocular symptoms were the first manifestation of malignancy in 17% of patients. Distant metastases to other organs were found in 82% of patients, but metastases to extra-orbital muscles were found in only 2 %.
  • Joejeff Johnson; Koji Abe; Hitosi Habe; Tomoko Hyodo; Kazunari Ishii
    2021 Annual Conference on Electronics, Information and Systems Institute of Electrical Engineers of Japan (IEEJ)  2021/09  online 
    In the treatment for hepatocellular carcinoma, sometimes physicians employ molecular targeted therapy. This paper presents a method for measuring the curative effects of the therapy using CT images. In the proposal, the size, the maximum diameter, and the density of the carcinoma are measured and the rate of change for each of the three values before and after the therapy is calculated. Finally, a value for the evaluation is outputted by utilizing the three rates. CT images were taken to 9 patients, and the value extracted from the images roughly showed the same as the correct answer.
  • A Single Breath-Hold Acquisition of Three-Dimensional T1 Mapping Using Look Locker sequence for Assessing Crohn Disease: A Phantom Study  [Not invited]
    Daisuke Morimoto-Ishikawa; Tomoko Hyodo; Shigeyoshi Saito; Yu Ueda; Masato Ohmi; Kazunari Ishii
    International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting & Exhibition  2021/05 
    SMRT Third Place Clinical Focus Electronic Poster Award
  • Synthetic DWI in prostate  [Not invited]
    Yu Ueda; Tsutomu Tamada; Makoto Obara; Tetsuo Ogino; Daisuke Morimoto-Ishikawa; Hiroyasu Sanai; Koji Yoshida; Ayumu Kido; Tomoko Hyodo; Kazunari Ishii; Masami Yoneyama; Marc Van Cauteren
    International Society for Magnetic Resonance in Medicine (ISMRM) & Society for MR Radiographers & Technologists (SMRT) Annual Meeting & Exhibition  2021/05
  • Optimization of the 3D Look Locker Sequence for Magnetic Resonance Enterocolonography  [Not invited]
    Daisuke Ishikawa; Tomoko Hyodo; Shigeyoshi Saito; Yu Ueda; Keizo Miyagoshi; Masato Oumi; Kazunari Ishii
    The 77th Annual Meeting of the Japanese Society of Radiological Technology  2021/04
  • Incidence of indistinct arterial enhancement on CT imaging after the initiation of anti-angiogenesis targeted therapy in hepatocellular carcinoma: Lenvatinib therapy compared with sorafenib therapy  [Not invited]
    Hyodo T; Ueshima K; Oda T; Kudo M; Ishii K
    The 32nd European Congress of Radiology  2020/07
  • The efficacy of the GRASE sequence compared to the compressed sensing technique for breath-hold three-dimensional MR cholangiopancreatography in patients with hyperintense bile on T1-weighted images  [Not invited]
    Morimoto D; Hyodo T; Itoh M; Fukushima H; Kamata K; Takenaka M; Miyagoshi K; Kudo M; Ishii K
    The 32nd European Congress of Radiology  2020/07
  • Iodine Density Imaging using Dual-energy CT in Patients with Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization: Morphological Operations of Ethiodized Oil Retention for Predicting Tumor Recurrence  [Not invited]
    Hyodo; T. Yagyu; Y. Kono; Y. Tsurusaki; M. Ueshima; K. Numoto; I. Ishii, K
    The 31st European Congress of Radiology  2019/02  Vienna
  • Dual-energy derived iodine density imaging based response assessment after conventional transcatheter arterial chemoembolization  [Invited]
    Hyodo T; Yukinobu Y; Kono Y; Numoto I; Tsurusaki M; Ueshima K; Kudo M; Ishii K
    The 25th Kanketsuryu-Dotai-Kino Image conference  2019/02
  • Tomoko Hyodo
    The 31st Annual Meeting of the Japanese Society for Radiation Oncology  2018/10  Kyoto 
    CT、MR検査の概要を述べたうえ、肝細胞がんの各種治療（穿刺局所療法、肝動脈化学塞栓療法、分子標的治療、放射線治療）の効果判定と治療後に生じる変化について、画像を提示しながら解説する。
  • Tomoko Hyodo
    The 46th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine  2018/09  Kanazawa 
    胆道・膵管の走向変異を中心に, MRCPやDIC-CTで見つけるべき異常所見を解説したうえ, 当院での使用経験を踏まえて1.5テスラ装置における圧縮センシング併用MRCPの有用性を述べる。
  • Evaluation of 3D magnetic resonance cholangiopancreatography with combined parallel imaging and compressed sensing reconstruction at 1.5T  [Not invited]
    Morimoto D; Ito M; Fukushima H; Konishi T; Nakatsuka T; Miyagoshi K; Mochizuki T; Hyodo T; Ishii KHyodo T; Ishii K
    The 46th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine  2018/09
  • How to avoid gadoxetic acid-related artefacts? Prospective multi-institutional study in 1994 patients.  [Not invited]
    Motosugi; U. Hori; M. Goshima; S. Kozaka; K. Hyodo; T. Nakamura; Y. Nishie; A. Tamada; T. Kanki, A
    The 30th European Congress of Radiology  2018/02
  • Iodine Density Imaging using Dual-energy CT in Patients with Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization: Quantitative Assessment of Ethiodized Oil Retention for Predicting Tumor Recurrence  [Not invited]
    Hyodo T; Yagyu Y; Kono Y; Oda T; Saitou T; Murakami T; Numoto I; Sasaki K; Ueshima K
    The 103rd Scientific Assembly & Annual Meeting of the Radiological Society of North America  2017/11
  • Virtual Unenhanced Algorithms for Fast-Kilovolt Switching Dual-Energy CT: Comparison Between Dedicated and Non-dedicated Softwares for Assessment of Liver Fat Content  [Not invited]
    Hyodo T; Yada N; Maenishi O; Sasaki K; Kono Y; Murakami T
    The 103rd Scientific Assembly & Annual Meeting of the Radiological Society of North America  2017/11
  • Liver Fat Quantification by using Dual-Energy CT  [Not invited]
    Tomoko Hyodo
    SAMI 2017 (Osaka)  2017/07 
    Two papers (Radiology 282(2):381-389 and Radiology 283(1):108-118) were introduced.
  • Histogram analysis of iodine density assessed by dual-energy imaging for predicting hepatocellular carcinoma recurrence after transcatheter arterial chemoembolization.  [Not invited]
    Hyodo; T. Yagyu; Y. Numoto; I. Tsurusaki; M. Im; S. Ueshima; K. Kudo; M. Murakami, T
    The 76th Annual Scientific Meeting of Japanease Radiological Society  2017/04
  • Accuracy of the Virtual Unenhancement Algorithm for Dual-Energy CT: Experimental Assessment on a Swine Liver Phantom  [Not invited]
    Kono Y; Shimomura K; Watanabe S; Kosaka H; Yamada K; Hyodo T; Sanada S
    the 73rd scientific assembly and annual meeting of the Japanese Society of Radiological Technology  2017/04
  • Tomoko Hyodo
    23rd Kanketsuryu-Dotai-Kino Image conference  2017/02
  • In Vitro Verification of the Virtual Unenhanced Algorithm  [Not invited]
    Tomoko Hyodo
    The 36th Annual Meeting of the Japanese Society of Medical Imaging  2017/02
  • Usefulness of Double Frequency MR Elastography for Assessment of the Necroinflammation on Liver Stiffness Measurements  [Not invited]
    Onoda M; Hyodo T; Murakami T; Tsurusaki M; Sakamoto T; Miyati TM
    The RSNA 102nd Scientific Assembly and Annual Meeting  2016/12
  • Dual-energy CT of the Liver  [Invited]
    Tomoko Hyodo
    AIMS Body Imaging 2016  2016/11
  • Reduced Iodine Dosage in Hepatic Dynamic CT Using Virtual Monochromatic Imaging with a Fast-kVp Switching Dual-Energy CT  [Not invited]
    Hyodo; T. Kumano; S. Nakanishi; J. Yada; N. Tsurusaki; M. Kudo; M. Murakami, T
    The 75th Annual Scientific Meeting of Japanease Radiological Society  2016/04
  • In Vitro Quantification of Fat Using MR Spectroscopy  [Not invited]
    Tomoko Hyodo; Masakatsu Tsurusaki; Takamichi Murakami
    The 35th annual meeting of the Japanese Society of Medical Imaging  2016/02
  • Iodine Load Reduction at Hepatic Dynamic CT using Virtual Monochromatic Imaging with a Fast kVp Switching Dual-Energy CT  [Not invited]
    Hyodo, T Kumano; M. Nakanishi; J. Uemura; M. Kudo; M Murakami; M Toguchi; M. Fukui; H Yada; N Ishii; K Mochizuki, T
    The RSNA 101st Scientific Assembly and Annual Meeting  2015/11
  • Iodine Load Reduction at Hepatic Dynamic CT: Usefulness of the Virtual Monochromatic Imaging using a Fast kVp Switching Dual-Energy CT.  [Not invited]
    Hyodo T; Nakanishi J; Asato N; Tsurusaki M; Matsuki M; Uemura M; Kudo M; Murakami T
    The 27th European Congress of Radiology-Scientific Exhibit.  2015/03
  • A Multi-Material Decomposition Algorithm for Liver Fat Quantification in Dual-Energy CT: Reproducibility of the Method, and Comparison with MR Spectroscopy  [Not invited]
    Hyodo; T. Yada; N. Maenishi; O. Lamb; P. Sasaki; K. Murakami; T. Tsurusaki; M. Ishii; K. Matsuki; M. Kumano; S. Mochizuki, T
    The RSNA 100th Scientific Assembly and Annual Meeting  2014/12
  • Utility of dual-energy CT  [Invited]
    Tomoko Hyodo
    第308回 日本医学放射線学会 関西地方会  2014/10
  • Tomoko Hyodo
    AIMS Abdominal Imaging  2014/10
  • Clinical applications and validation of a multi-material decomposition algorithm for liver and fat quantification with dual-energy CT  [Not invited]
    Hyodo; T. Yada; N. Maenishi; O. Kudo; M. Asato; N. Tsurusaki; M. Matsuki; M. Ishii; K. Kudo; M. Murakami, T
    The 73rd Annual Scientific Meeting of Japanease Radiological Society  2014/04
  • Quantitative Correlation between Liver Fat and Biopsy Score Using Multi-material Decomposition and Fast-kV Switching Dual-energy CT.  [Not invited]
    Kudo; M. Hyodo; T Murakami; M Lamb; P. Mendonça; P. R.S; Uemura, M
    99th Radiological Society of North America  2013/12  Chicago  99th Radiological Society of North America
  • Applications of the Fast kVp Switching Dual Energy CT for Hepatopancreato-biliary Imaging.  [Not invited]
    Hyodo; T Okada; M Kudo; M. Tsurusaki; M Mochizuki; T Ishii; K Murakami, M
    99th Radiological Society of North America  2013/12  Chicago  99th Radiological Society of North America
  • F-18 FDG-PET/CT検査にて経過観察しえた原発性肝神経内分泌腫瘍の1例  [Not invited]
    兵頭 朋子; 村上 卓道; 松木 充; 岡田 真広; 柳生 行伸; 鶴崎 正勝; 足利 竜一朗; 井上 達夫; 木村 雅友; 石井 一成
    第27回日本腹部放射線研究会  2013/06  宇都宮  第27回日本腹部放射線研究会
  • Quantitative assessment of liver fat with dual energy CT: comparison with MR spectroscopy  [Not invited]
    Hyodo T; Kudo M; Lamb P; Mendonça PRS; Okada M; Yada N; Maenishi O; Ishii K; Murakami M
    Computer Assisted Radiology and Surgery, 27th Intemational Congress and Exhibition  2013/06  ドイツ  Computer Assisted Radiology and Surgery, 27th Intemational Congress and Exhibition
  • Dual-energy CTによる肝脂肪定量：ファントム実験によるsingle-energy CTおよびMRSとの比較  [Not invited]
    兵頭 朋子; 岡田 真広; 鶴崎 正勝; 足利 竜一朗; 石井 一成; 村上 卓道; 工藤 正幸
    第72回日本医学放射線学会総会  2013/04  横浜  第72回日本医学放射線学会総会
  • Phantom study of liver fat quantification in dual-energy CT: comparison to single-energy CT and MR spectroscopy.  [Not invited]
    Hyodo T; Okada M; Kudo M; Ishii K; Mochizuki T; Murakami T
    The 25th European Congress of Radiology  2013/03  Vienna  25th European Congress of Radiology
  • 兵頭朋子; 岡田真広; 工藤正幸; 鶴崎正勝; 足利竜一朗; 石井一成; 村上卓道
    日本医学放射線学会総会抄録集  2013/02
  • Quantitative Evaluation of Hepatobiliary Function: A Compartment Model Analysis with Gadoxetic Acid-enhanced MRI  [Not invited]
    Onoda; M. Hyodo; T. Okada; M. Myati; T. Murakami; T. Uto, T
    98th Radiological Society of North America  2012/12  アメリカ  98th Radiological Society of North America
  • Distinguishing Neurodegeneratice Dementia with MRI,FDG-PET,and PiB-PET  [Not invited]
    石井 一成; 村上 卓道; 兵頭 朋子; 高橋 洋人; 岡田 真広
    98th Radiological Society of North America  2012/11  アメリカ  98th Radiological Society of North America
  • Can Virtual Monochromatic Image with Dual-Energy CT Correct Beam Hardening Effect and Reduce Contrast Agent? Phantom Experiment.  [Not invited]
    Kudo M; Hyodo T; Yamada K; Sengupta S; Murakami T
    98th Radiological Society of North America  2012/11  アメリカ  98th Radiological Society of North America
  • Feasibility of early scan of brain FDG-PET in patients with dementia  [Not invited]
    Hyodo T; Ishii K; Sakaguchi K; Hanaoka K; Usami K; Shimamoto K; Yamazoe Y; Yamada M; Matsuki M; Hosono M; Murakami T
    The 52nd Annual Scientific Meeting of the Japanese Society of Nuclear Medicine  2012/10  札幌  第52回日本核医学会学術総会
  • 兵頭朋子; 岡田真広; 矢田典久; 前西修; 香川祐毅; 任誠雲; 柏木伸夫; 柳生行伸; 今岡いずみ; 松木充; 足利竜一朗; 石井一成; 工藤正俊; 村上卓道
    近畿大学医学雑誌  2012/09
  • 兵頭朋子; 石井一成; 坂口健太; 花岡宏平; 宇佐美公男; 島元健次; 山添譲; 山田穣; 松木充; 細野眞; 村上卓道
    核医学  2012/08
  • 肝血行動態解析によるソラフェニブ治療効果の早期予測-CT perfusionを用いて  [Not invited]
    兵頭 朋子; 村上 卓道; 岡田 真広; 香川 祐毅; 日高 正二朗; 任 誠雲; 栁生 行伸; 上嶋 一臣; 矢田 典久; 石井 一成; 工藤 正俊; 工藤 正幸
    第48回日本肝癌研究会  2012/07  石川  第48回日本肝癌研究会
  • CT perfusionによる肝血行動態解析：sorafenib投与による背景肝血流の変化と肝細胞癌治療効果  [Not invited]
    兵頭 朋子; 村上 卓道; 岡田 真広; 香川 祐毅; 日高 正二朗; 栁生 行伸; 上嶋 一臣; 矢田 典久; 松木 充; 石井 一成; 工藤 正俊
    第12回関西肝血流動態イメージ研究会  2012/06  大阪  第12回関西肝血流動態イメージ研究会
  • Hypovascular nodules presenting with hypointensity in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI in cirrhotic patients: Risk factors for hypervascularization. American Roentgen Ray Society Annual Meeting  [Not invited]
    兵頭 朋子; 岡田 真広; 香川 祐毅; 村上 卓道; 堀 雅敏; 今井 康陽
    JRS 2011 Annual Meeting award winning scientific electronic exhibits  2012/04  Vancouver  JRS 2011 Annual Meeting award winning scientific electronic exhibits
  • Dual energy CTを用いた肝脂肪の定量評価：ファントム実験と初期臨床経験  [Not invited]
    兵頭 朋子; 岡田 真広; 村上 卓道; 工藤 正俊; 矢田 典久; 工藤 正幸
    第71回日本医学放射線学会学術集会  2012/04  横浜  第71回日本医学放射線学会学術集会
  • 兵頭朋子; 岡田真広; 香川祐毅; 熊野正士; 任誠雲; 柏木伸夫; 柳生行伸; 今岡いずみ; 足利竜一朗; 石井一成; 工藤正俊; 村上卓道
    近畿大学医学雑誌  2011/12
  • Evaluation of Hepatic Enhancement of Gd-EOB-DTPA: Comparison of T1 Value and Signal Intensity  [Not invited]
    Onoda; M. Hyodo; T. Murakami; T. Okada; M. Kumano; S. Myati, T
    The RSNA 97th Scientific Assembly and Annual Meeting  2011/12
  • Hyodo; T. Okada; M. Hori; M. Imai; Y. Kudo; M. Murakami; T. Mochizuki; T. Kagawa; Y. Kogita; S. Kumano, S
    The RSNA 97th Scientific Assembly and Annual Meeting  2011/12
  • In-vitro evaluation of coronary artery stents by 64ch MDCT: Improvement in luminal visualization using high definition scan mode with adaptive statistical iterative reconstruction technique  [Not invited]
    Hyodo; T. Nakauchi; Y. Yamada; K. Kudo; M. Mochizuki; T. Murakami; T. Okada; M. Ishii, K
    The RSNA 97th Scientific Assembly and Annual Meeting  2011/12
  • 兵頭朋子; 石井一成; 細野眞; 阪本祐一; 米矢吉宏; 柳生行伸; 土屋典生; 熊野正士; 足利竜一朗; 中村一郎; 植村天受; 村上卓道
    核医学  2011/11
  • 中西順子; 山田浩司; 兵頭朋子; 工藤正幸
    日本冠疾患学会雑誌  2011/11
  • Assessment of hepatobiliary phase Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection ability versus MDCT.  [Not invited]
    Inoue T; Kudo M; Arizumi T; Hayaishi S; Takita M; Kitai S; Yada N; Hagiwara S; Minami Y; Ueshima K; Okada M; Hyodo T; Murakami T
    The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)  2011/11  San Francisco, USA  The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Atypical Imaging of Liver Hemangioma: Pictorial Review by Gd-EOB-DTPA-enhanced MRI, Dynamic CT and Sonography.  [Not invited]
    岡田 真広; 兵頭 朋子; 香川 祐毅; 工藤 正俊; 村上 卓道; 沼田 和司
    RSNA - Scientific Poster Session  2011/11  Chicago  RSNA - Scientific Poster Session
  • Hepatocellular Carcinoma: Pictorial Review for the Planning of Therapy and the Evaluation after Therapy.  [Not invited]
    岡田 真広; 兵頭 朋子; 香川 祐毅; 工藤 正俊; 村上 卓道; 沼田 和司
    RSNA - Educational Poster Session  2011/11  Chicago  RSNA - Educational Poster Session
  • CT Perfusionによる肝細胞癌の分子標的薬治療効果予測  [Not invited]
    兵頭 朋子; 香川 祐毅; 岡田 真広; 日高 正二朗; 柳生 行伸; 熊野 正士; 柏木 伸夫; 小塚 健倫; 今岡 いずみ; 足利 竜一朗; 石井 一成; 工藤 正俊; 北野 雅之; 上嶋 一臣; 井上 達夫; 矢田 典久; 村上 卓道; 工藤 正幸
    第2回大阪消化器画像・IVR研究会  2011/09  大阪  第2回大阪消化器画像・IVR研究会
  • 小腸イレウスをきたした硬化性腸間膜炎の1例  [Not invited]
    兵頭 朋子; 熊野 正士; 村上 卓道; 津田孝治; 上田和毅; 前西 修
    第２５回日本腹部放射線研究会  2011/06  大阪  第２５回日本腹部放射線研究会
  • Hypovascular nodules presented with hypointensity on the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI in patients with chronic liver disease: Inciden ce and risk factors of developing hypervascular hepatocellular carcinoma  [Not invited]
    Hyodo T; Okada M; Kagawa Y; Kumano S; Hori M; Ishii K; Imai Y; Mochizuki T; Kudo M; Murakami T
    The 70th Annual Meeting of the Japan Radiological Society (JRS) Congress  2011/05  Web開催  第70回日本医学放射線学会学術集会
  • Hypovascular nodules presented with hypointensity on the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI in the cirrhotic liver: Implications for developing hypervascular hepatocellular carcinoma  [Not invited]
    Hyodo T; Okada M; Kagawa Y; Kogita S; Kumano S; Imaoka I; Hori MI, K; Imai Y; Mochizuki T; Kudo M; Murakami T
    The International Society for Magnetic Resonance in Medicine 19th Annual Meeting  2011/05  Montr?al  the International Society for Magnetic Resonance in Medicine 19th Annual Meeting.
  • 兵頭朋子; 岡田真広; 香川祐毅; 熊野正士; 堀雅敏; 石井一成; 今井康陽; 望月輝一; 工藤正俊; 村上卓道
    第70回日本医学放射線学会学術集会  2011/02
  • 兵頭朋子; 津田孝治; 平田雅昭; 武智恵; 田中宏明; 望月輝一
    日本医学放射線学会総会抄録集  2010/02
  • Gastrografin CT Enterography (G-CTE): A Minimally Invasive Method for Small Bowel Disorders  [Not invited]
    Hyodo; T. Okizuka; Y. Hirata; M. Tanaka; H. Tsuda; T. Mochizuki, T
    The RSNA 95th Scientific Assembly and Annual Meeting  2009/12
  • 兵頭朋子; 起塚香子; 平田雅昭; 村上正哲; 津田孝治; 望月輝一
    第68回日本医学放射線学会総会  2009/02
  • 起塚香子; 兵頭朋子; 平田雅昭; 村上正哲; 津田孝治; 望月輝一
    第68回日本医学放射線学会学術発表会  2009/02
  • 兵頭朋子; 津田孝治; 平田雅昭; 村上正哲; 望月輝一
    第67回日本医学放射線学会総会  2008/02
  • Portal branches in the caudate lobe of the liver: demonstration by three-dimensional CT during arterial portography  [Not invited]
    Hyodo; T. Tsuda; T. Hirata; M. Murakami; M. Mochizuki, T
    The RSNA 93rd Scientific Assembly and Annual Meeting  2007/12
  • Evaluation of the Hepatic Hilar Bile Ducts Using 3D DIC-CT by 16 Channel MDCT: What Should We Know?  [Not invited]
    Hyodo; T. Tsuda; T. Hirata; M. Kumano; S. Mochizuki, T
    The RSNA 92nd Scientific Assembly and Annual Meeting  2006/12
  • 浜本泰; 片岡正明; 兵頭朋子; 居倉美穂; 井上武; 最上博
    日本医学放射線学会学術集会抄録集  2005/02
  • 兵頭朋子; 片岡正明; 浜本泰; 居倉美穂; 井上武; 最上博; 日浦昌道
    第64回日本医学放射線学会総会  2005/02
  • 最上博; 井上武; 兵頭朋子; 居倉美穂; 浜本泰; 片岡正明
    日本医学放射線学会学術集会抄録集  2005/02
  • 浜本泰; 片岡正明; 兵頭朋子; 居倉美穂; 井上武; 最上博
    日本医学放射線学会学術集会抄録集  2005/02
  • 居倉美穂; 井上武; 兵頭朋子; 最上博; 浜本泰; 大住省三; 高嶋成光; 菊池恵一; 望月輝一
    日本医学放射線学会学術集会抄録集  2005/02
  • 居倉美穂; 片岡正明; 浜本泰; 坂本香奈; 兵頭朋子; 井上武; 最上博; 高嶋成光
    日本医学放射線学会雑誌  2005/01
  • 坂本香奈; 最上博; 兵頭朋子; 居倉美穂; 浜本泰; 井上武; 片岡正明; 中田昌男
    日本医学放射線学会雑誌  2004/07
  • 浜本泰; 片岡正明; 居倉美穂; 坂本香奈; 兵頭朋子; 井上武; 最上博
    日本医学放射線学会雑誌  2004/07
  • 兵頭朋子; 最上博; 坂本香奈; 居倉美穂; 浜本泰; 井上武; 片岡正明; 中田昌男
    日本医学放射線学会雑誌  2004/07
  • 最上博; 兵頭朋子; 坂本香奈; 居倉美穂; 井上武; 浜本泰; 片岡正明
    日本医学放射線学会雑誌  2004/02
  • 兵頭朋子; 最上博; 坂本香奈; 居倉美穂; 浜本泰; 井上武; 片岡正明
    第63回日本医学放射線学会総会  2004/02
  • 片岡正明; 浜本泰; 居倉美穂; 坂本香奈; 兵頭朋子; 井上武; 最上博
    日本医学放射線学会雑誌  2004/02
  • 浜本泰; 片岡正明; 兵頭朋子; 坂本香奈; 居倉美穂; 井上武; 最上博
    日本医学放射線学会雑誌  2004/02
  • 坂本香奈; 最上博; 兵頭朋子; 居倉美穂; 井上武; 浜本泰; 片岡正明
    日本医学放射線学会雑誌  2004/02
  • 兵頭朋子; 最上博; 坂本香奈; 居倉美穂; 浜本泰; 井上武; 片岡正明
    第63回日本医学放射線学会総会  2004/02
  • 居倉美穂; 井上武; 坂本香奈; 兵頭朋子; 最上博; 浜本泰; 片岡正明
    日本医学放射線学会雑誌  2004/02
  • 最上博; 兵頭朋子; 坂本香奈; 居倉美穂; 井上武; 浜本泰; 片岡正明; 中田昌男
    肺癌  2003/10
  • 兵頭朋子; 最上博; 坂本香奈; 居倉美穂; 浜本泰; 井上武; 片岡正明; 中田昌男
    第44回日本肺癌学会総会  2003/10
  • 最上博; 坂本香奈; 兵頭朋子; 居倉美穂; 井上武; 浜本泰; 片岡正明; 中田昌男
    肺癌  2003/10
  • 坂本香奈; 兵頭朋子; 居倉美穂; 浜本泰; 井上武; 片岡正明; 最上博; 中田昌男
    肺癌  2003/10
  • 最上博; 井上武; 坂本香奈; 兵頭朋子; 居倉美穂; 片岡正明
    日本医学放射線学会雑誌  2003/02
  • 片岡正明; 井上武; 居倉美穂; 坂本香奈; 兵頭朋子; 最上博
    日本医学放射線学会雑誌  2003/02
  • 兵頭朋子; 石丸良広; 山田雅文; 橋本拓造; 森内昭
    日本医学放射線学会雑誌  2002/06
  • 兵頭朋子; 田中宏明; 菅田成紀; 山本浩司; 津田孝治; 望月輝一; 池添潤平; 宮川直子
    日本医学放射線学会雑誌  2001/11
  • 兵頭朋子; 松田健; 村上忠司; 居倉博彦; 安原美文; 越智誉司; 津田孝治; 望月輝一; 池添潤平
    日本医学放射線学会雑誌  2001/06

MISC

Awards & Honors

  • 2022/04 The 78th Annual Meeting of the Japanese Society of Radiological Technology JSRT Silver Prize
     "Initial research on native T1 mapping focused on the detection of active ulcerative colitis" 
    受賞者: Daisuke Ishikawa;Tomoko Hyodo;Yoriaki Komeda;Yu Ueda;Keizo Miyagoshi;Shigeyoshi Saito;Kazunari Ishii
  • 2022/03 The 84th National Convention of Information Processing Society of Japan Student Encouragement Award of IPSJ National Convention
     Detection of Early-Stage Dense Areas in CT Images for Determining the Effect of Hepatocellular Carcinoma Therapy 
    受賞者: Hiromi Fukuda;Hitoshi Habe;Koji Abe;Tomoko Hyodo;Kazunari Ishii
  • 2021/05 ISMRM & SMRT Annual Meeting & Exhibition. SMRT Third Place Clinical Focus Electronic Poster Award
     "A Single Breath-Hold Acquisition of Three-Dimensional T1 Mapping Using Look Locker sequence for Assessing Crohn Disease: A Phantom Study" 
    受賞者: Morimoto-Ishikawa D;Hyodo T;Saito S;Ueda Y;Ohmi M;Ishii K
  • 2013 The RSNA 99th Scientific Assembly and Annual Meeting Cum Laude
     "Applications of the Fast kVp Switching Dual Energy CT for Hepatopancreato biliary Imaging"
  • 2013 Nichidoku-Iho Best Paper Award 2012
     "Clinical Utility of Dual Energy CT Imaging"
  • 2012 第12回関西肝血流動態イメージ研究会 Grand Prize
     "CT perfusion: Changes in HCC and the liver hemodynamics after targeted therapy"
  • 2011 The 70th Annual Meeting of the Japan Radiological Society Gold Medal
     "Hypovascular nodules presented with hypointensity on the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI in patients with chronic liver disease: Inciden ce and risk factors of developing hypervascular hepatocellular carcinoma"
  • 2009 The Japanese College of Radiology Armed Forces Institute of Pathology fellowship

Research Grants & Projects

Other link

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