MURAI Yoshihiro

    General Education Coordinating Committee Associate Professor
Last Updated :2024/03/24

Researcher Information

Degree

  • (BLANK)
  • (BLANK)

J-Global ID

Research Interests

  • 有機化学   organic chemistry   

Research Areas

  • Life sciences / Bioorganic chemistry
  • Nanotechnology/Materials / Structural/physical organic chemistry

Education

  •        - 1988  Toyama Medical and Pharmaceutical University  薬学研究科  医療薬科学
  •        - 1988  Toyama Medical and Pharmaceutical University  Graduate School, Division of Pharmaceutical Sciences
  •        - 1983  Tamagawa University  College of Agriculture  農芸化学科
  •        - 1983  Tamagawa University  Faculty of Agriculture

Association Memberships

  • 日本生薬学会   日本化学会   和漢医薬学会   日本薬学会   

Published Papers

  • マグノロールおよびホノキオールの配糖体合成と生理活性について
    2022/02
  • Ingredient research of Triforium repen L. and Alpinia oxyphylla
    2022/02
  • Development of resist material by Grignard reaction
    yoshihiro murai
    Research Reports of Faculty of Engineering (No.54) 23 - 27 2021/02 [Refereed]
  • The relation of print and the brush strokes of the hiragana
    YOSHIHIRO MURAI
    Research Reports of the Faculty of Engineering Kindai University (53) 23 - 26 2019/12 [Refereed]
  • Harmony in the print of the hiragana
    YOSHIHIRO MURAI
    Research Reports of the Faculty of Engineering Kindai University (53) 27 - 31 2019/12 [Refereed]
  • Attemputs to physical principules elcidate by the scale-Relationship of vibration and the scale of material
    MURAI Yoshihiro
    (52) 63 - 69 2018/12 [Refereed]
  • Transliterration Heat Sutra-Heart Sutra and the human genome
    MURAI Yoshihiro
    RESEARCH REPORTS OF THE FACULTY OF ENGINEERING KINDAI UNIVERSITY (52) 57 - 62 2018/12 [Refereed]
  • M Ishifune; H Yamashita; Y Kera; N Yamashita; K Hirata; H Murase; S Kashimura
    ELECTROCHIMICA ACTA PERGAMON-ELSEVIER SCIENCE LTD 48 (17) 2405 - 2409 0013-4686 2003/07 
    Regioselective electroreduction of the aromatics, including methoxybenzenes, by using LiClO4 as a supporting electrolyte in an aprotic solvent (THF) containing alcoholic proton donors such as t-BuOH was successfully achieved to afford the corresponding 1,4-cyclohexadienes regioselectively in high yield. The electrolysis can, be performed under constant current conditions at ambient temperature. The effect of electrode materials was remarkable, that is, the use of Mg electrodes gave the best result. Moreover in the presence of t-BuOD instead of t-BuOH, the deutrated 1,4-cyclohexadienes were obtained in high deuterium incorporation at 1- and 4-positions. A direct electron transfer to the aromatics is unlikely, and it is reasonable that the solvated Li(0), which is generated by the cathodic reduction of LiClO4, is intermediately involved in the electron transfer with being assisted by the anodically generated Mg2+ as an electron transfer catalyst. (C) 2003 Elsevier Science Ltd. All rights reserved.
  • S Kashimura; H Yamashita; Y Murai; Y Kera; N Yamashita; H Murase; M Ishifune
    ELECTROCHIMICA ACTA PERGAMON-ELSEVIER SCIENCE LTD 48 (1) 7 - 10 0013-4686 2002/11 [Refereed]
     
    Electroreduction of aliphatic esters in THF was found to be promoted by the catalytic amount of porphine-magnesium(II) complexes and afforded 2-alkoxytetrahydrofuran derivatives, the coupling products between alkoxide anions formed by the electroreduction of aliphatic esters and THF cation generated by the anodic oxidation of the solvent (THF). In this reaction, chlorophyll a extracted from Trifolium repens L was remarkably effective. In addition, lanthanide metal(III) ions such as samarium trichloride were also found to be effective for the electroreduction of aliphatic esters. (C) 2002 Elsevier Science Ltd. All rights reserved.
  • Shigenori Kashimura; Yoshihiro Murai; Yoshihiro Tamai; Ryuich Hirose; Manabu Ishifune; Hirokazu Iwase; Hajime Yamashita; Natsuki Yamashita; Hiroya Kakegawa
    Electrochimica Acta 46 (20-21) 3301 - 3307 0013-4686 2001/07 [Refereed]
     
    A comparative cyclic voltabsorptometric study was carried out for polyaniline (PAn) films prepared by electrochemical polymerization and vacuum thermal evaporation. The absorption values were measured at different characteristic wavelengths (895, 755, 665, 435, and 325 nm) corresponding to the individual absorption bands separated by us earlier from the spectra using the Alentsev-Fock method. Differential voltabsorptometric curves (dA/dt vs. potential (DCVA)) measured in aqueous HCl were compared with ordinary cyclic voltammetry (CVA). The experiments for different sweep rates were also compared. It was found that the DCVA peak at 895 nm corresponds perfectly to the CVA peak both in the electrosynthesized and the vacuum deposited PAn. The DCVA peak at 435 nm (cation-radicals) precedes the CVA peak (similar to the maximum of the EPR signal), while that at 755 nm (polarons or cation-radical dimers) lags behind the CVA peak. For the vacuum deposited films an intense intermediate DCVA and current peaks (at a bout 0.6 V vs. Ag/AgCl) are observed. The results are discussed in terms of the heterogeneous structure of PAn particularly, its specific features in the films prepared using different methods. © 2001 Elsevier Science Ltd. All rights reserved.
  • M Ishifune; H Yamashita; M Matsuda; H Ishida; N Yamashita; Y Kera; S Kashimura; H Masuda; H Murase
    ELECTROCHIMICA ACTA PERGAMON-ELSEVIER SCIENCE LTD 46 (20-21) 3259 - 3264 0013-4686 2001/07 
    Electroreduction of aliphatic esters to form 2-alkoxytetrahydrofurans was achieved by using a new paired electrolysis system, that consists of the cathodic reduction of aliphatic esters and the anodic oxidation of the solvent (THF). It was also found that the presence of magnesium ion in the electrolyte promoted the electroreduction of aliphatic esters remarkably. In fact, the electroreduction of aliphatic esters was found to proceed toward 2-alkoxytetrahydrofurans by using a platinum cathode and anode in the presence of anodically dissolved magnesium ions. (C) 2001 Elsevier Science Ltd. All rights reserved.
  • M Ishifune; S Kashimura; Y Kogai; Y Fukuhara; T Kato; HB Bu; N Yamashita; Y Murai; H Murase; R Nishida
    JOURNAL OF ORGANOMETALLIC CHEMISTRY ELSEVIER SCIENCE SA 611 (1-2) 26 - 31 0022-328X 2000/10 [Refereed]
     
    The stepwise elongation of Si-Si or Si-Ge chain was achieved by the electroreductive cross-coupling reaction of chlorohydrosilanes with dichlorooligosilanes using magnesium electrodes. The electroreductive cross-coupling reaction of chlorodimethylsilane (1) with dichlorodiphenylsilane (2) or dichlorodiphenylgermane (4), for instance, gave 1,2-dihydro-1,1,3,3-tetramethyl-2,2-diphenyltrisilane (3) or bis(hydrodimethylsilyl)germane (5) in good yield. Compounds 3 and 5 were readily transformed to the corresponding 1,3-dichlorotrisilane (6) and bis(chlorosilyl)germane (7), respectively. The electroreductive polymerization of the resulting dichlorooligosilanes using magnesium electrodes in tetrahydrofuran was successfully applied to the synthesis of sequence-ordered polysilanes. (C) 2000 Elsevier Science S.A. All rights reserved.
  • S Kashimura; M Ishifune; N Yamashita; HB Bu; M Takebayashi; S Kitajima; D Yoshiwara; Y Kataoka; R Nishida; S Kawasaki; H Murase; T Shono
    JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 64 (18) 6615 - 6621 0022-3263 1999/09 
    The electroreduction of alkylaryldichlorosilane carried out with Mg cathode and anode in a single compartment cell gave high molecular weight poly(alkylarylsilane) (M-n = 5200-31000, M-w/M-n = 1.4-1.8) in 5-79% yield. The effects of electrode material, monomer concentration, amount of supplied electricity, and ultrasound were investigated. This electroreductive method was also successfully applied to the synthesis of polygermanes, silane-geramane copolymers, and also poly[p- (disilanylene)phenylenes].
  • Y Matsumura; M Nishimura; H Hiu; M Watanabe; N Kise
    JOURNAL OF ORGANIC CHEMISTRY AMER CHEMICAL SOC 61 (8) 2809 - 2812 0022-3263 1996/04 [Refereed]
     
    Oxidative coupling of phenylacetic acid esters was easily achieved by treating the esters with TiCl4 and then adding Et(3)N to the resulting solution. The products consisted of dl- and meso-2,3-diphenylsuccinic acid esters with the Claisen condensation product, and the ratio of these products depended on the reaction conditions. Reaction conditions suitable for high db selectivity were determined, and a dimer of titanium enolate was postulated as an intermediate responsible for the high db selectivity. The selectivities were compared with those in known oxidative couplings in which titanium enolate intermediates are prepared through lithium enolates and silyl enol ethers. The results suggest that the reactivities of titanium enolates intermediates depend on how they are generated.
  • N KISE; N INAKOSHI; Y MATSUMURA
    TETRAHEDRON LETTERS PERGAMON-ELSEVIER SCIENCE LTD 36 (6) 909 - 912 0040-4039 1995/02 [Refereed]
     
    Both diastereomers of 3-amino-2-hydroxyalkanoic acid derivatives were synthesized selectively by LDA-induced reaction of N-methoxycarbonyl-1-methoxyamines with O-protected N,N-dimethylglycolamides. The inversion of the diastereoselectivity was highly achieved by 1) selecting the O-protecting groups and 2) the addition of Ti(OPr-i)(4).

Books etc

  • 有機電解合成の新展開
    シーエムシー出版 2004

MISC

Research Grants & Projects

  • 日本学術振興会:科学研究費助成事業
    Date (from‐to) : 1994 -1994 
    Author : 柏村 成史; 村井 義洋; 庄野 達哉
     
    我々は、反応性電極としてマグネシウム電極を用いる電極還元系が極めて強い還元力を有し、かつ、興味深い反応性を有することを既に見い出し、この反応系を用いた広範な有機合成反応を既に開拓している。本重点領域研究では、トロポン、アズレン等の非ベンゼン系芳香族化合物を、反応性電極にマグネシウムを用いて電極還元するという新しい手法により、種々の金属と非ベンゼン系芳香族化合物との安定な錯体の合成とその有機反応への応用を行うことを目的として研究を行った結果、種々のアルキル置換基を有するアズレン誘導体を反応性電極としてマグネシウムを用いて電極還元することにより、アズレン誘導体2分子が7一位で位置選択的にカップリングした層状マグネシウム-錯体が高収率で生成することを見い出した。また、これらの層状マグネシウム-錯体とサマリウム、ユーロピウム等のランタノイド類の金属塩を反応させることにより、対応するランタノイド金属錯体が効率良く生成することを明かにした。さらに、上述のマグネシウムおよびランタノイド錯体と種々の親電子剤との反応を検討した結果、これらの錯体が高い求核性を有しており、ハロゲン化ルキル、アルデヒドおよびケトン等の種々の親電子剤と位置選択的に反応することをも見い出した。これらの生成物が容易に酸化されてアズレン誘導体を再生することを明かにし、この反応を用いてアズレン類の2一位に位置選択的に置換基を導入する有効な方法を開拓することにも成功した。
  • 民間薬からの天然物に関する研究
  • Study on Natural products from Folk Medicine


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