KINDAI UNIVERSITY


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岡村 大治オカムラ ダイジ

プロフィール

所属部署名農学部 バイオサイエンス学科 / 農学研究科
職名講師
学位博士(医学)
専門発生生物学
ジャンル科学・技術/遺伝子・DNA技術
コメンテータガイドhttp://www.kindai.ac.jp/meikan/1359-okamura-daiji.html
ホームページURLhttps://kaken.nii.ac.jp/d/r/80393263.ja.html
メールアドレスdokamura[at]nara.kindai.ac.jp
Last Updated :2018/02/23

コミュニケーション情報 byコメンテータガイド

コメント

    ES細胞やiPS細胞に代表される多能性幹細胞の最新技術と、その応用事例の解説(再生医療・創薬・家畜育種への利用など)、また生殖細胞を利用した生殖医療の技術解説が可能です。

報道関連出演・掲載一覧

    <報道関連出演・掲載一覧>

    ●2017/2/17
     日本経済新聞
     異なる動物の細胞を用いた臓器細胞研究について

学歴・経歴

経歴

  •   2015年04月,  - 現在, 近畿大学(講師)
  •   2012年04月,  - 2015年03月, ソーク研究所(Research Associate)
  •   2004年04月,  - 2012年03月, 東北大学(助教)

研究活動情報

研究分野

  • 生物科学, 発生生物学

研究キーワード

  • 多能性幹細胞, エピブラスト, 始原生殖細胞, マウス, ES細胞, 分化, 多能性, エピジェネティクス

論文

  • CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs., Wu J, Vilarino M, Suzuki K, Okamura D, Bogliotti YS, Park I, Rowe J, McNabb B, Ross PJ, Belmonte JCI, Scientific reports, 7, 1, 10487,   2017年09月, 査読有り
  • Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells., Suzuki A, Hirasaki M, Hishida T, Wu J, Okamura D, Ueda A, Nishimoto M, Nakachi Y, Mizuno Y, Okazaki Y, Matsui Y, Izpisua Belmonte JC, Okuda A, Nature communications, 7, 11056,   2016年03月, 査読有り
  • An alternative pluripotent state confers interspecies chimaeric competency., Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC, Nature, 521, 7552, 316, 321,   2015年05月, 査読有り
  • Selective elimination of mitochondrial mutations in the germline by genome editing., Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC, Cell, 161, 3, 459, 469,   2015年04月, 査読有り
  • On the fate of primordial germ cells injected into early mouse embryos., Leitch HG, Okamura D, Durcova-Hills G, Stewart CL, Gardner RL, Matsui Y, Papaioannou VE, Developmental biology, 385, 2, 155, 159,   2014年01月, 査読有り
  • Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells., Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, Okamura D, Wu MZ, Dubova I, Esteban CR, Montserrat N, Campistol JM, Izpisua Belmonte JC, Nature cell biology, 15, 12, 1507, 1515,   2013年12月, 査読有り
  • Max is a repressor of germ cell-related gene expression in mouse embryonic stem cells., Maeda I, Okamura D, Tokitake Y, Ikeda M, Kawaguchi H, Mise N, Abe K, Noce T, Okuda A, Matsui Y, Nature communications, 4, 1754,   2013年, 査読有り
  • REST and its downstream molecule Mek5 regulate survival of primordial germ cells., Okamura D, Mochizuki K, Taniguchi H, Tokitake Y, Ikeda M, Yamada Y, Tournier C, Yamaguchi S, Tada T, Schöler HR, Matsui Y, Developmental biology, 372, 2, 190, 202,   2012年12月, 査読有り
  • Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells., Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte JC, Matsui Y, Genes & development, 26, 22, 2477, 2482,   2012年11月, 査読有り
  • Cardiosphere-derived cells for heart regeneration., Masuda S, Montserrat N, Okamura D, Suzuki K, Izpisua Belmonte JC, Lancet (London, England), 379, 9835, 2425, 6; author reply 2426,   2012年06月, 査読有り
  • Requirement of Oct3/4 function for germ cell specification., Okamura D, Tokitake Y, Niwa H, Matsui Y, Developmental biology, 317, 2, 576, 584,   2008年05月, 査読有り
  • Discordant developmental waves of angioblasts and hemangioblasts in the early gastrulating mouse embryo., Furuta C, Ema H, Takayanagi S, Ogaeri T, Okamura D, Matsui Y, Nakauchi H, Development (Cambridge, England), 133, 14, 2771, 2779,   2006年07月, 査読有り
  • Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm., Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA, Aizawa S, Matsui Y, Matsuo I, Developmental cell, 9, 5, 639, 650,   2005年11月, 査読有り
  • Mechanisms of germ-cell specification in mouse embryos., Matsui Y, Okamura D, BioEssays : news and reviews in molecular, cellular and developmental biology, 27, 2, 136, 143,   2005年02月, 査読有り
  • Mouse epiblasts change responsiveness to BMP4 signal required for PGC formation through functions of extraembryonic ectoderm., Okamura D, Hayashi K, Matsui Y, Molecular reproduction and development, 70, 1, 20, 29,   2005年01月, 査読有り
  • Cadherin-mediated cell interaction regulates germ cell determination in mice., Okamura D, Kimura T, Nakano T, Matsui Y, Development (Cambridge, England), 130, 26, 6423, 6430,   2003年12月, 査読有り

MISC

  • Interspecies Chimerism with Mammalian Pluripotent Stem Cells, Jun Wu, Aida Platero-Luengo, Masahiro Sakurai, Atsushi Sugawara, Maria Antonia Gil, Takayoshi Yamauchi, Keiichiro Suzuki, Yanina Soledad Bogliotti, Cristina Cuello, Mariana Morales Valencia, Daiji Okumura, Jingping Luo, Marcela Vilariño, Inmaculada Parrilla, Delia Alba Soto, Cristina A. Martinez, Tomoaki Hishida, Sonia Sánchez-Bautista, M. Llanos Martinez-Martinez, Huili Wang, Alicia Nohalez, Emi Aizawa, Paloma Martinez-Redondo, Alejandro Ocampo, Pradeep Reddy, Jordi Roca, Elizabeth A. Maga, Concepcion Rodriguez Esteban, W. Travis Berggren, Estrella Nuñez Delicado, Jeronimo Lajara, Isabel Guillen, Pedro Guillen, Pedro Guillen, Josep M. Campistol, Emilio A. Martinez, Pablo Juan Ross, Juan Carlos Izpisua Belmonte, Cell, 168,   2017年01月26日, 10.1016/j.cell.2016.12.036, https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010695864&origin=inward
    概要:© 2017 Elsevier Inc. Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several tissues of gene-edited organogenesis-disabled mice. Besides gaining insights into species evolution, embryogenesis, and human disease, interspecies blastocyst complementation might allow human organ generation in animals whose organ size, anatomy, and physiology are closer to humans. To date, however, whether human PSCs (hPSCs) can contribute to chimera formation in non-rodent species remains unknown. We systematically evaluate the chimeric competency of several types of hPSCs using a more diversified clade of mammals, the ungulates. We find that naïve hPSCs robustly engraft in both pig and cattle pre-implantation blastocysts but show limited contribution to post-implantation pig embryos. Instead, an intermediate hPSC type exhibits higher degree of chimerism and is able to generate differentiated progenies in post-implantation pig embryos.