KINDAI UNIVERSITY


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宮澤 正顯ミヤザワ マサアキ

プロフィール

所属部署名医学科 / 医学研究科
職名教授/主任
学位医学博士
専門ウイルス感染免疫学
ジャンル科学・技術/遺伝子・DNA技術
コメンテータガイドhttp://www.kindai.ac.jp/meikan/490-miyazawa-masaaki.html
ホームページURLhttp://www.med.kindai.ac.jp/immuno/
メールアドレス
Last Updated :2017/09/14

コミュニケーション情報 byコメンテータガイド

コメント

    エイズウイルスやインフルエンザウイルスに対する宿主の抵抗性を決める遺伝子を研究しています。厚生労働科研費の研究代表者を長く務め、イタリア・フランス・タイなどと共同研究しています。

報道関連出演・掲載一覧

    <報道関連出演・掲載一覧>
    ●2015/11/17
     日本テレビ系列「情報ライブ ミヤネ屋」
     HIVの治療法について。
    ●2015/06/25
     朝日放送「キャスト」
     HIV感染に関する医学的根拠について。
    ●2014/08/13
     毎日放送「ちちんぷいぷい」
     エボラ出血熱について。
    ●2014/08/05
     毎日放送「ちちんぷいぷい」
     STAP細胞について。

学歴・経歴

学歴

  •  - 1983年, 東北大学, 医学研究科, 病理学系専攻
  •  - 1982年, 東北大学, 医学部, 医学科

経歴

  •   1984年,  - 1995年, 東北大学医学部 助手
  •   1986年,  - 1990年, アメリカ合衆国国立感染症アレルギー研究所客員研究員
  •   1995年,  - 1996年, 三重大学医学部 助教授
  •   1996年,  - 現在, 近畿大学医学部 教授、近畿大学大学院医学研究科担当
  •   2016年,  - 現在, 近畿大学大学院医学研究科長

研究活動情報

研究分野

  • 基礎医学, 人類遺伝学
  • 基礎医学, 実験病理学
  • 基礎医学, ウイルス学
  • 基礎医学, 免疫学

研究キーワード

  • エピトープ, CD4陽性T細胞, Tリンパ球, ワクチン, 効果的なワクチンの開発, 感染抵抗性, 免疫応答遺伝子, 自己免疫病

論文

  • Simian Immunodeficiency Virus Targeting of CXCR3+ CD4+ T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets., Fujino M, Sato H, Okamura T, Uda A, Takeda S, Ahmed N, Shichino S, Shiino T, Saito Y, Watanabe S, Sugimoto C, Kuroda M, Ato M, Nagai Y, Izumo S, Matsushima K, Miyazawa M, Ansari AA, Villinger F, Mori K, Journal of virology,   2017年04月, 査読有り
  • Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis., Yoshikawa T, Wu J, Otsuka M, Kishikawa T, Suzuki N, Takata A, Ohno M, Ishibashi R, Yamagami M, Nakagawa R, Kato N, Miyazawa M, Han J, Koike K, Gastroenterology, 152, 3, 631, 643,   2017年02月, 査読有り
  • Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance., Takamura S, Yagi H, Hakata Y, Motozono C, McMaster SR, Masumoto T, Fujisawa M, Chikaishi T, Komeda J, Itoh J, Umemura M, Kyusai A, Tomura M, Nakayama T, Woodland DL, Kohlmeier JE, Miyazawa M, The Journal of experimental medicine, 213, 13, 3057, 3073,   2016年12月, 査読有り
  • マウスAPOBEC3の生理機能と分子進化, 宮澤 正顯,博多 義之,武田 英里,李 君,河原 佐智代, 生化学, 88, 5, 582, 592,   2016年, 査読有り
  • A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells., Hakata Y, Tsuchiya S, Michiue H, Ohtsuki T, Matsui H, Miyazawa M, Kitamatsu M, Chemical communications (Cambridge, England), 51, 2, 413, 416,   2015年01月, 査読有り
  • Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection., Kato M, Tsuji-Kawahara S, Kawasaki Y, Kinoshita S, Chikaishi T, Takamura S, Fujisawa M, Kawada A, Miyazawa M, Journal of virology, 89, 2, 1468, 1473,   2015年01月, 査読有り
  • Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest., Hakata Y, Miyazawa M, Landau NR, Virology journal, 11, 108,   2014年06月, 査読有り
  • Reply to "CD8+ T cells are essential for controlling acute friend virus infection in C57BL/6 mice"., Tsuji-Kawahara S, Takamura S, Miyazawa M, Journal of virology, 88, 9, 5202, 5203,   2014年05月, 査読有り
  • Infection of adult thymus with murine retrovirus induces virus-specific central tolerance that prevents functional memory CD8+ T cell differentiation., Takamura S, Kajiwara E, Tsuji-Kawahara S, Masumoto T, Fujisawa M, Kato M, Chikaishi T, Kawasaki Y, Kinoshita S, Itoi M, Sakaguchi N, Miyazawa M, PLoS pathogens, 10, 3, e1003937,   2014年03月, 査読有り
  • Elimination of friend retrovirus in the absence of CD8+ T cells., Tsuji-Kawahara S, Miyazawa M, Journal of virology, 88, 3, 1854, 1855,   2014年02月, 査読有り
  • Differential requirements of cellular and humoral immune responses for Fv2-associated resistance to erythroleukemia and for regulation of retrovirus-induced myeloid leukemia development., Tsuji-Kawahara S, Kawabata H, Matsukuma H, Kinoshita S, Chikaishi T, Sakamoto M, Kawasaki Y, Miyazawa M, Journal of virology, 87, 24, 13760, 13774,   2013年12月, 査読有り
  • IFN-γ-producing effector CD8 T lymphocytes cause immune glomerular injury by recognizing antigen presented as immune complex on target tissue., Tsumiyama K, Hashiramoto A, Takimoto M, Tsuji-Kawahara S, Miyazawa M, Shiozawa S, Journal of immunology (Baltimore, Md. : 1950), 191, 1, 91, 96,   2013年07月, 査読有り
  • 生理的に機能するレトロウイルス複製制限因子APOBEC3の分子進化, 宮澤正顯, ウイルス, 62, 1, 27, 38,   2012年06月, 査読有り
  • Two genetic determinants acquired late in mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency., Li J, Hakata Y, Takeda E, Liu Q, Iwatani Y, Kozak CA, Miyazawa M, PLoS pathogens, 8, 1, e1002478,   2012年01月, 査読有り
  • In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke., Hayasaka N, Nagai N, Kawao N, Niwa A, Yoshioka Y, Mori Y, Shigeta H, Kashiwagi N, Miyazawa M, Satou T, Higashino H, Matsuo O, Murakami T, PloS one, 7, 2, e32342,   2012年, 査読有り
  • An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases., Sironi M, Guerini FR, Agliardi C, Biasin M, Cagliani R, Fumagalli M, Caputo D, Cassinotti A, Ardizzone S, Zanzottera M, Bolognesi E, Riva S, Kanari Y, Miyazawa M, Clerici M, Molecular biology and evolution, 28, 12, 3319, 3329,   2011年12月, 査読有り
  • Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo., Ogawa T, Tsuji-Kawahara S, Yuasa T, Kinoshita S, Chikaishi T, Takamura S, Matsumura H, Seya T, Saga T, Miyazawa M, Journal of virology, 85, 11, 5423, 5435,   2011年06月, 査読有り
  • Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice., Hayasaka, N., K. Aoki, S. Kinoshita, S. Yamaguchi, J. K. Wakefield, S. Tsuji-Kawahara, K. Horikawa, H. Ikegami, S. Wakana, T. Murakami, R. Ramabhadran, M. Miyazawa, and S. Shibata., PLoS ONE, 6, e17655,   2011年, 査読有り
  • Diversity of MHC class I genes in Burmese-origin rhesus macaques., Naruse, T. K., Z. Chen, R. Yanagida, T. Yamashita, Y. Saito, K. Mori, H. Akari,Y. Yasutomi, M. Miyazawa, T. Matano, and A. Kimura., Immunogenetics, 62, 9, 601, 611,   2010年, 査読有り
  • Response to comment on "Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors.”, Takamura, S. and M. Miyazawa, J. Immunol., 185, 1349, 1350,   2010年, 査読有り
  • Development of a new disinfectant with very strong anti-influenza-viral activity: a preliminary report, Takakuwa, H., T. Maruoka, T. Hata, M. Miyazawa, T. Hata, H. Toshimori, and K. Otsuki, Environmental Health and Preventive Medicine, 15, 2, 121, 123,   2010年, 査読有り
  • Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV., Sugimoto C., S. Watanabe, T. Naruse, E. Kajiwara, T. Shiino, N. Umano, K. Ueda, H. Sato, S. Ohgimoto, V. Hirsch, F. Villinger, A. A. Ansari, A. Kimura, M. Miyazawa, Y. Suzuki, N. Yamamoto, Y. Nagai, and K. Mori., PLoS One, 5, e11678,   2010年, 査読有り
  • Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in Friend virus-infected mice., Tsuji-Kawahara, S., T. Chikaishi, E. Takeda, M. Kato, S. Kinoshita, E. Kajiwara, S. Takamura, and M. Miyazawa., J. Virol., 84, 12, 6082, 6095,   2010年, 査読有り
  • Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors., Takamura, S., S. Tsuji-Kawahara, H. Yagita, H. Akiba, M. Sakamoto, T. Chikaishi, M. Kato, and M. Miyazawa, J. Immunol., 184, 9, 4696, 4707,   2010年, 査読有り
  • Mouse APOBEC3 affects the production of virus-neutralizing antibodies by restricting early retroviral replication, not by altering the B-cell repertoir, Miyazawa, M., S. Tsuji-Kawahara, T. Chikaishi, M. Kato and S. Takamura, Retrovirology O9, 2009., 6, Suppl 2, O9,   2009年
  • The ‘immunologic advantage’ of HIV-exposed seronegative individuals, Miyazawa, Masaaki; Lopalco, Lucia; Mazzotta, Francesco; Caputo, Sergio Lo; Veas, Francisco; Clerici, Mario; for the ESN Study Group, AIDS, 23, 2, 161–175,   2009年, 査読有り
  • Mouse APOBEC3 restricts Friend leukemia virus infection and pathogenesis in vivo., Takeda E, Tsuji-Kawahara S, Sakamoto M, Langlois MA, Neuberger MS, Rada C, Miyazawa M, Journal of Virology, 82, 22, 10998, 11008,   2008年11月, 査読有り
  • Decreased expression of intestinal chemokine TECK/CCL25 in experimental obstructive jaundice and its reversal following internal biliary drainage, Taku Matsumoto, Tetsuo Ajiki , Eiji Kajiwara, Yoshiyasu Mita, Tsunenori Fujita, Haruki Morimoto, Masaaki Miyazawa and Yonson Ku, Journal of Gastroenterology, 43, 5, 0944-1174, 396,   2008年, 査読有り
  • Host genetic factors that control immune responses to retrovirus infections., Miyazawa, M., S. Tsuji-Kawahara, and Y. Kanari., Vaccine, 26, 24, 2981, 2996,   2008年, 査読有り
  • Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals., Biasin M, Piacentini L, Lo Caputo S, Kanari Y, Magri G, Trabattoni D, Naddeo V, Lopalco L, Clivio A, Cesana E, Fasano F, Bergamaschi C, Mazzotta F, Miyazawa M, Clerici M, The Journal of infectious diseases, 195, 960–964, 960, 964,   2007年04月, 査読有り
  • Reference strand-mediated conformation analysis-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci., Tanaka-Takahashi Y, Yasunami M, Naruse T, Hinohara K, Matano T, Mori K, Miyazawa M, Honda M, Yasutomi Y, Nagai Y, Kimura A, Electrophoresis, 28, 6, 918, 924,   2007年03月, 査読有り
  • Vaccine-based long-term stable control of simian-human immunodeficiency virus 89.6PD replication in rhesus macaques., Yamamoto, H., M. Kawada, T. Tsukamoto, A. Takeda, H. Igarashi, M. Miyazawa, T. Naruse, M. Yasunami, A. Kimura, and T. Matano., J. Gen. Virol., 88, 2, 652, 659,   2007年, 査読有り
  • MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression., Kajikawa M, Baba T, Tomaru U, Watanabe Y, Koganei S, Tsuji-Kawahara S, Matsumoto N, Yamamoto K, Miyazawa M, Maenaka K, Ishizu A, Kasahara M, Journal of Immunology (Baltimore, Md. : 1950), 177, 5, 3108, 3115,   2006年09月, 査読有り
  • Increased liver temperature efficiently augments human cellular immune response: T cell activation and possible monocyte translocation., Kida, Y., S. Tsuji-Kawahara, V. Ostapenko, S. Kinoshita, E. Kajiwara, H. Kawabata, T. Yuasa, I. Nishide, S. Yukawa, M. Ichinose, and M. Miyazawa., Cancer Immunology, Immunotherapy, 55, 1459-1469, 1459, 1469,   2006年, 査読有り
  • Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model., Mori K, Sugimoto C, Ohgimoto S, Nakayama EE, Shioda T, Kusagawa S, Takebe Y, Kano M, Matano T, Yuasa T, Kitaguchi D, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, Yamamoto N, Suzuki Y, Nagai Y, Journal of virology, 79, 16, 10386, 10396,   2005年08月, 査読有り
  • Genotypes at chromosome 22q12-13 are associated with HIV-1-exposed but uninfected status in Italians., Kanari Y, Clerici M, Abe H, Kawabata H, Trabattoni D, Caputo SL, Mazzotta F, Fujisawa H, Niwa A, Ishihara C, Takei YA, Miyazawa M, AIDS (London, England), 19, 1015, 1024,   2005年07月, 査読有り
  • [Pathogenesis of granulomatous arteritis]., Miyazawa M, Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 5, 217, 222,   2005年05月, 査読有り
  • Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease, Kawabata, H., A. Niwa, S. Tsuji-Kawahara, H. Uenishi, N. Iwanami, H. Matsukuma, H. Abe, N. Tabata, H. Matsumura, and M. Miyazawa, International Immunology, 18, 1, 183, 198,   2005年, 査読有り
  • Influence of glycosylation on the efficacy of an Env-based vaccine against SIVmac239 in a macaque AIDS model, Mori, K., C. Sugimoto, S. Ohgimoto, E. E. Nakayama, T. Shioda, S. Kusagawa, Y. Takebe, M. Kano, T. Matano, T. Yuasa, D. Kitaguchi, M. Miyazawa, Y. Takahashi, M. Yasunami, A. Kimura, N. Yamamoto, Y. Suzuki, and Y. Nagai., Journal of Virology, 79, 10386, 10396,   2005年, 査読有り
  • Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicity., Sugahara D, Tsuji-Kawahara S, Miyazawa M, Journal of virology, 78, 12, 6322, 6334,   2004年06月, 査読有り
  • Both T and non-T cells with proliferating potentials are effective in inducing suppression of allograft responses by alloantigen-specific intravenous presensitization combined with suboptimal doses of 15-deoxyspergualin., Tahara H, Iwanami N, Tabata N, Matsumura H, Matsuura T, Kurita T, Miyazawa M, Transplant immunology, 13, 25, 32,   2004年06月, 査読有り
  • Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial (共著), Matano, T., M. Kobayashi, H. Igarashi, A. Takeda, H. Nakamura, M. Kano, C. Sugimoto, K. Mori, A. Iida, T. Hirata, M. Hasegawa, T. Yuasa, M. Miyazawa, Y. Takahashi, M. Yasunami, A. Kimura, D. H. O'Connor, D. I. Watkins, and Y. Nagai., The Journal of Experimental Medicine, 199, 1709-1718, 1709, 1718,   2004年, 査読有り
  • マウスレトロウイルス感染と発症:宿主因子による制御機構, 宮澤正顯, ウイルス, 52, 1, 69, 76,   2002年06月, 査読有り
  • Close association between Fas ligand (FasL; CD95L)-positive tumor-associated macrophages and apoptotic cancer cells along invasive margin of colorectal carcinoma: a proposal on tumor-host interactions., Sugita J, Ohtani H, Mizoi T, Saito K, Shiiba K, Sasaki I, Matsuno S, Yagita H, Miyazawa M, Nagura H, Cancer Science, 93, 3, 320, 328,   2002年03月, 査読有り
  • Changes in the number of gut mucosal T-lymphocytes and macrophages in patients treated by external biliary drainage., Fukuoka K, Ajiki T, Miyazawa M, Takeyama Y, Onoyama H, Kuroda Y, The European journal of surgery = Acta chirurgica, 167, 9, 684, 688,   2001年09月, 査読有り
  • Suppression of cell proliferation by tissue plasminogen activator during the early phase after balloon injury minimizes intimal hyperplasia in hypercholesterolemic rabbits (共著), Kanamasa, Ken; Otani, Narutaka; Ishida, Norihiro; Inoue, Yoshikazu; Ikeda, Akiko; Morii, Hideki; Naito, Norikatsu; Hayashi, Takahiro; Ishikawa, Kinji; Miyazawa, Masaaki, Journal of Cardiovascular Pharmacology, 37, 2, 155, 162,   2001年, 査読有り
  • Role of natural killer cells in resistance against Friend retrovirus-induced leukemia (共著), Iwanami, N., A. Niwa, Y. Yasutomi, N. Tabata, and M. Miyazawa, Journal of Virology, 75, 7, 3152, 3163,   2001年, 査読有り
  • In vitro cytokine production of peripheral blood mononuclear cells in response to HCV core antigen stimulation during interferon-beta treatment and its relevance to sCD8 and sCD30., Izuma M, Kobayashi K, Shiina M, Ueno Y, Ishii M, Shimosegawa T, Toyota T, Kakimi K, Miyazawa M, Hepatology research : the official journal of the Japan Society of Hepatology, 18, 3, 218, 229,   2000年11月, 査読有り
  • Roles of endogeneous retroviruses and platelets in the development of vascular injury in spontaneous mouse models of autoimmune diseases, Miyazawa M, International journal of cardiology, 75, Suppl 1, S65, S73,   2000年08月, 査読有り
  • Induction of microthrombotic thrombocytopenia in normal mice by transferring a platelet-reactive, monoclonal anti-gp70 autoantibody established from MRL/lpr mice: an autoimmune model of thrombotic thrombocytopenic purpura, K. Hashimoto, N. Tabata, R. Fujisawa, H. Matsumura, M. Miyazawa, Clinical and Experimental Immunology, 119, 47, 56,   2000年, 査読有り
  • Establishment of monoclonal anti-retroviral gp70 autoantibodies from MRL/lpr lupus mice and induction of glomerular gp70 deposition and pathology by transfer into non-autoimmune mice (共著), Tabata, N., M. Miyazawa, R. Fujisawa, Y. A. Takei, H. Abe, and K. Hashimoto, Journal of Virology, 74, 9, 4116, 4126,   2000年, 査読有り
  • Anti-cytoplasmic autoantibodies reactive with epithelial cells of the salivary gland in sera from patients with Sjögren's syndrome: their disease- and organ-specificities., Sakamoto M, Miyazawa M, Mori S, Fujisawa R, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 28, 1, 20, 25,   1999年01月, 査読有り
  • Protein Kinase Cα promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage, Hiroyuki Okuda, Masaaki Adachi, Masaaki Miyazawa, Yuji Hinoda, Kohzoh Imai, Oncogene, 18, 5604, 40, 5604, 5609,   1999年, 査読有り
  • Squirrel monkey retrovirus (SMRV) sequence from an SMRV-negative cell line?, Masaaki Miyazawa, Yoshiaki Yanai, Masashi Kurimoto, Journal of Hepatology, 31, 5, 967, 967,   1999年, 査読有り
  • Expression and characterization of a very low density lipoprotein receptor variant lacking the O-linked sugar region generated by alternative splicing., Iijima H, Miyazawa M, Sakai J, Magoori K, Ito MR, Suzuki H, Nose M, Kawarabayasi Y, Yamamoto TT, Journal of biochemistry, 124, 4, 747, 755,   1998年10月, 査読有り
  • Detection of endogenous retrovirus antigens in NOD mouse pancreatic beta-cells(共著), Lab. Animal, 32, 1, 86, 94,   1998年, 査読有り
  • Detection of endogenous retrovirus antigens in NOD mouse pancreatic beta-cells, Tsumura H, Miyazawa M, Ogawa S, Wang JZ, Ito Y, Shimura K, Laboratory Animals, 32, 1, 86, 94.,   1998年, 査読有り
  • [Molecular mimicry and mechanisms of autoantibody production]., Miyazawa M, Nihon rinsho. Japanese journal of clinical medicine, 55, 6, 1370, 1376,   1997年06月, 査読有り
  • Restriction of Friend virus-induced erythroid cell proliferation by CD4+ T-lymphocytes that recognize a single gp70 epitope, MIYAZAWA Masaaki, FUJISAWA Ryuichi, Lenkemia, 11, Suppl 3, 227, 229,   1997年, 査読有り
  • Proliferation of macrophage-lineage cells in the bone marrow, severe thymic atrophy, and extramedullary hematopoiesis of possible donor origin in an autopsy case of post-transplantation graft-versus-host disease., Kazama T, Miyazawa M, Tsuchiya S, Horii A, Bone marrow transplantation, 18, 2, 437, 441,   1996年08月, 査読有り
  • Immunophenotypic characterization of Epstein-Barr virus-associated gastric carcinoma: massive infiltration by proliferating CD8+ T-lymphocytes., Saiki Y, Ohtani H, Naito Y, Miyazawa M, Nagura H, Laboratory Investigation; a journal of technical methods and pathology, 75, 1, 67, 76,   1996年07月, 査読有り
  • Vascular lesions in mice with a deficitin Fas-mediated apoptosis and their transfer, Masato Nose, Mitsuko R. Ito, Masao Ono, Shizuko Terasaki, Masaaki Miyazawa, Shiro Mori, International Journal of Cardiology, 54, S35, S44,   1996年, 査読有り
  • Characterization of novel monoclonal antibodies raised against formalin-fixed,paraffin-embedded human ameloblastoma, Kumamoto H, Miyazawa M, Ooya K, Journal of Oral Pathology and Medicine, 25, 484, 490,   1996年, 査読有り
  • A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes., Kondo T, Uenishi H, Shimizu T, Hirama T, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Fujisawa R, Miyazawa M, Journal of virology, 69, 11, 6735, 6741,   1995年11月, 査読有り
  • Immunization with a single T helper cell epitope abrogates Friend virus-induced early erythroid proliferation and prevents late leukemia development., Miyazawa M, Fujisawa R, Ishihara C, Takei YA, Shimizu T, Uenishi H, Yamagishi H, Kuribayashi K, Journal of Immunology (Baltimore, Md. : 1950), 155, 2, 748, 758,   1995年07月, 査読有り
  • Establishment of a new human cell line, LI90, exhibiting characteristics of hepatic Ito (fat-storing) cells, Murakami K, Abe T, Miyazawa M, Yamaguchi M, Masuda T, Matsuura T, Nagamori S, Takeuchi K, Abe K, Kyogoku M, Laboratory Investigation; a journal of technical methods and pathology, 72, 6, 731, 739,   1995年, 査読有り
  • Contrasting effects from a single major histocompatibility complex class II molecule (H-2E) in recovery from Friend virus leukemia., Perry LL, Miyazawa M, Hasenkrug K, Wehrly K, David CS, Chesebro B, Journal of virology, 68, 8, 4921, 4926,   1994年08月, 査読有り
  • Interstitial nephritis in Aleutian mink disease. Possible role of cell-mediated immunity against virus-infected tubular epithelial cells., Mori S, Nose M, Miyazawa M, Kyogoku M, Wolfinbarger JB, Bloom ME, The American journal of pathology, 144, 6, 1326, 1333,   1994年06月, 査読有り
  • Production and characterization of new monoclonal antibodies that distinguish subsets of mink lymphoid cells, Miyazawa M, Mori S, Spangrude GJ, Wolfinbarger JB, Bloom ME, Hybridoma, 13, 2, 107, 114,   1994年, 査読有り
  • Physiology and pathology of host immune responses to exogenous and endogenous murine retroviruses from gene fragments to epitopes, MIYAZAWA Masaaki, FUJISAWA Ryuichi, Tohoku Journal of Experimental Medicine, 173, 91, 1, 91, 103,   1994年
  • Immunoelectron microscopic localization of transforming growth factor beta 1 and latent transforming growth factor beta 1 binding protein in human gastrointestinal carcinomas: qualitative difference between cancer cells and stromal cells., Mizoi T, Ohtani H, Miyazono K, Miyazawa M, Matsuno S, Nagura H, Cancer research, 53, 1, 183, 190,   1993年01月, 査読有り
  • A macrophage differentiating factor derived from human T cell line HUT 102 acting on a mouse myeloid cell line M1, Kanno H, Nose M, Niki T, Miyazawa M, Kyogoku M, Tohoku Journal of Experimental Medicine, 171, 1, 43, 52,   1993年, 査読有り
  • Multipilicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells, Iwashiro M, Kondo T, Shimizu T, Yamagishi H, Takahashi K, Matsubayashi Y, Masuda T, Otaka A, Fujii N, Ishimoto A, Miyazawa M, Robertson MN, Chesebro B, Kuribayashi K, Journal of Virology, 67, 8, 4533, 4542,   1993年, 査読有り
  • Subacute panencephalitis associated with chronic graft-versus-host disease, Iwasaki Y, Sako K, Ohara Y, Miyazawa M., Minegishi M, Tsuchiya S, Konno K, Acta Neuropathologica, 85, 5, 566, 572,   1993年, 査読有り
  • Protection against Friend retrovirus-induced leukemia by recombinant vaccinia viruses expressing the gag gene., Miyazawa M, Nishio J, Chesebro B, Journal of virology, 66, 7, 4497, 4507,   1992年07月, 査読有り
  • Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia., Miyazawa M, Nishio J, Wehrly K, Jay G, Melvold RW, Chesebro B, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, 19, 3, 159, 164,   1992年06月, 査読有り
  • Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC., Miyazawa M, Nishio J, Wehrly K, David CS, Chesebro B, Journal of immunology (Baltimore, Md. : 1950), 148, 6, 1964, 1967,   1992年03月, 査読有り
  • Use of low-toxicity adjuvants and killed virus to induce protective immunity against the Friend murine leukemia retrovirus-induced disease, Ishihara C, Miyazawa M., Nishio J, Azuma I, Chesebro B, Vaccine, 10, 5, 353, 356,   1992年, 査読有り
  • Paralysis of street rabies virus-infected mice is dependent on T lymphocytes, Sugamata M, Miyazawa M, Mori S, Spangrude GJ, Ewalt LC, Lodmell DL, Journal of Virology, 66, 2, 1252, 1260,   1992年, 査読有り
  • Influence of MHC genes on spontaneous recovery from Friend retrovirus-induced leukemia, Miyazawa M, Nishio J, Wehrly K, Chesebro B, The Journal of Immunology, 148, 2, 644, 647,   1992年, 査読有り
  • Replication of Aleutian mink disease parvovirus in lymphoid tissues of adult mink: Involvement of follicular dendritic cells and macrophages, Mori S, Wolfinbarger JB, Miyazawa M, Bloom ME, Journal of Virology, 65, 2, 952, 956,   1991年, 査読有り
  • Production of monoclonal antibodies reactive with a denatured form of the Friend murine leakemia virus gp70 envelope protein, Robertson MN, Miyazawa M, Mori S, Caughey B, Evans LH, Hayes SF, Chesebro B, Journal of Virological Methods, 34, 3, 255, 271,   1991年, 査読有り
  • Induction of protective immunity to Friend murine leukemia virus in genetic nonresponders to virus envelope protein, Ishihara C, Miyazawa M, Nishio J, Chesebro B, The Journal of Immunology, 146, 11, 3958, 3963,   1991年, 査読有り
  • Host genetic control of spontaneous and induced immunity to Friend murine retrovirus infection (共著), Chesebro, M. Miyazawa, and W. J. Britt., Annual Review of Immunology, 8, 477-499, 477, 499,   1990年, 査読有り
  • Establishment and characterization of mouse leukemia cell lines L615K and L7212K derived from transplantable murine leukemias maintained in China., You S, Maeda S, Murao S, Takahashi R, Ishikawa J, Miyazawa M, Nose M, Sugiyama T, Japanese journal of cancer research : Gann, 80, 5, 444, 451,   1989年05月, 査読有り
  • Genetic control of T cell responsiveness to the Friend murine leukemia virus envelope antigen. Identification of class II loci of the H-2 as immune response genes., Miyazawa M, Nishio J, Chesebro B, The Journal of experimental medicine, 168, 5, 1587, 1605,   1988年11月, 査読有り
  • Pathogenesis of arteritis of SL/Ni mice. Possible lytic effect of anti-gp70 antibodies on vascular smooth muscle cells., Miyazawa M, Nose M, Kawashima M, Kyogoku M, The Journal of experimental medicine, 166, 4, 890, 908,   1987年10月, 査読有り
  • Immunopathology of murine lupus-overview, SL/Ni and MRL/Mp-lpr/lpr-., Kyogoku M, Nose M, Sawai T, Miyazawa M, Tachiwaki O, Kawashima M, Progress in clinical and biological research, 229, 95, 130,   1987年, 査読有り
  • [Animal disease model of vasculitis--immune complex and host factors]., Nose M, Miyazawa M, Tachiwaki O, Kyogoku M, Nihon rinsho. Japanese journal of clinical medicine, 43, 10, 2044, 2051,   1985年10月, 査読有り

書籍等出版物

  • Host genes that influence immune and non-immune resistance mechanisms against retrovrial infections, Recent Research Developements in Virology,   2005年
  • Tumor Imaging (共著) , Encyclopedia of Immunology, 2nd edition,   1998年
  • Pathogenicity of autoantibodies reactive with the endogenous retroviral envelope glycoprotein gp70 (In "From Animal Models to Human Genetics: Research on the Induction and Pathogenicity of Autoantibodies"), Pabst Science Publishers,   2004年
  • 解明病理学 病気のメカニズムを解く, 医歯薬出版,   2009年, 978-4-263-73115-4
  • 述2, 明石書店,   2008年, 978-4-7503-2749-5

講演・口頭発表等

  • Mouse APOBEC3 affects the production of virus-neutralizing antibodies by restricting early retroviral replication, not by altering the B-cell repertoire., Frontiers of Retrovirology.,   2009年
  • Mechanisms of immune evasion by Friend virus: T-cell exhaustion, B-cell hyperactivation, and their genetic control., 21st International Workshop on Retroviral Pathogenesis.,   2009年
  • Host genes controlling immune responses to retroviral infections and genetic correlates of HIV-1-reposed but uninfected status., 1st International Symposium on Genetic and Immune Correlates of HIV Infection and Vaccine-Induced Immunity.,   2007年
  • Host resistence genes in immunity against human and mouse retroviral infections., Virology Africa 2005,   2005年
  • A cluster of retrovirus-restricting genes in mouse chromosome 15 and syntenic human chromosome 22 and their effects on Friend virus infection., 19th International Workshop on Retroviral Pathogenesis,   2007年
  • Genetic basis for resistance against retroviral infections − from mouse models to humans., Third International Workshop on Immunology and Infectious Diseases,   2004年
  • HIV-1感染抵抗性を賦与する新規宿主遺伝子の解析とその作用機序, 第21回日本エイズ学会学術集会・総会,   2007年
  • Host genetic factors that control immune resistance to HIV-1 infection., 7th AIDS Seminar in Kumamoto,   2006年
  • ビルマ産アカゲザルMHC class II領域のハプロタイプ構成と組換えの解析, ビルマ産アカゲザルMHC class II領域のハプロタイプ構成と組換えの解析,   2006年
  • Host genes controlling immune responses to retroviral infections and genetic correlates of HIV-1-reposed but uninfected status., 1st International Symposium on Genetic and Immune Correlates of HIV Infection and Vaccine-Induced Immunity.,   2007年
  • New metabolic markers derived from gamma and deltaretrovirus envelope glycoproteins., 21st International Workshop on Retroviral Pathogenesis.,   2009年
  • Genetic factors that confer resistance to HIV-1 acquisition in HIV-1-exposed but seronegative individuals in Italy and Thailand., 4th Nagasaki Symposium on Tropical and Emerging Infectious Diseases.,   2009年
  • レトロウイルス遺伝子発現と糸球体病変: 拡大するヒトレトロウイルスの世界 (特別講演), 第45回日本小児腎臓病学会学術集会,   2010年
  • 性感染症の最近の動向: HIVと性器クラミジアを中心に (教育講演), 第19回日本口腔感染症学会総会・学術大会,   2010年
  • HIV感染移行性の分子機構: Rac2とAPOBEC3, 第24回日本エイズ学会学術集会・総会,   2010年

作品

  • エイズ感染防御を含む新しいワクチンへの現代的アプローチに関するコールドスプリングハーバー研究所シンポジウムシンポジスト,   1989年
  • ワクチン開発のための新しい化学的・遺伝的アプローチに関するコールドスプリングハーバー研究所シンポジウムシンポジスト,   1987年
  • 乳酸菌製剤の抗ウイルス免疫賦活能,   1999年 - 2000年
  • ヘルパーT細胞を活性化するエイズワクチンの開発,   2000年 - 2005年
  • 温熱によるC-型肝炎ウイルス免疫応答の増強,   2001年 - 2007年
  • HIV曝露非感染者の遺伝要因の解明,   2002年
  • 新型インフルエンザワクチンの作用機序,   2006年

特許

  • Method for diagnosis and induction of resistance to virus., International Patent Application PCT/JP2007/068591
  • Resistance Genes, International Patent Application PCT/GB2005/005078
  • 新規ヒト内在性レトロウイルスHC2のenv遺伝子, 特願2004-231412
  • Marker Genes, PCT/GB2003/004493

受賞

  •   1989年, 東北大学医学部奨学賞
  •   1990年, 難病医学研究財団研究奨励助成金
  •   2002年, ノバルティス リウマチ医学賞
  •   2007年, 内藤記念科学奨励金

競争的資金