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MORISHIMA Masaki

    Department of Food Science and Nutrition　Associate Professor
Last Updated :2023/03/24

Researcher Information

J-Global ID

Research Interests

  • 公衆栄養学   病態生理学   循環器学   応用栄養学   運動習慣   

Research Areas

  • Life sciences / Nutrition and health science
  • Life sciences / Healthcare management, medical sociology
  • Life sciences / Nutrition and health science
  • Life sciences / Clinical pharmacy
  • Life sciences / Physiology

Academic & Professional Experience

  • 2022/04 - Today  Kindai University農学部食品栄養学科准教授
  • 2019/04 - 2021/03  近畿大学農学部食品栄養学科講師
  • 2016/04 - 2019/03  The University of Tokushima糖尿病対策センター特任講師
  • 2017/09 - 2018/12  Drexel University College of MedicineDept. Pharmacology and Physiology客員研究員
  • 2007/04 - 2016/03  Oita UniversityFaculty of Medicine助教
  • 2006/10 - 2007/04  Oita UniversityFaculty of Medicine研究支援者
  • 2006/04 - 2006/09  Oita UniversityFaculty of Medicine技術補佐員

Education

  • 2003/04 - 2006/03  The University of Tokushima  栄養学研究科  博士後期課程
  • 2001/04 - 2003/03  The University of Tokushima  栄養学研究科  博士前期課程

Association Memberships

  • 日本栄養改善学会   JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE   JAPANESE HEART RHYTHM SOCIETY   JAPANESE SOCIETY OF PATHOPHYSIOLOGY   日本神経科学会   日本生理学会   THE JAPAN DIABETES SOCIETY   

Published Papers

Conference Activities & Talks

  • Polyunsaturated fatty acids and cardiovascular health  [Invited]
    Masaki Morishima
    The 100th Anniversary Annual Meeting of The Physiological Society of Japan  2023/03
  • コロナ禍に負けない身体づくりと食環境整備  [Invited]
    森島 真幸
    はりま産学交流会  2022/10
  • 未利用食材の活用によるポストコロナ時代の食環境整備  [Invited]
    森島 真幸
    近畿大学研究シーズ発表会  2022/09

MISC

Industrial Property Rights

Awards & Honors

  • 2022/08 日本病態生理学会 学部学生・修士課程大学院生セッション 優秀賞
     妊娠・授乳期のヘスペリジンの摂取が母子の免疫機能に及ぼす影響 
    受賞者: 松永華奈;山本こはる;堀井鴻佑;森島真幸
  • 2021/03 日本循環器学会 Circulation Journal誌 年間優秀論文賞（Experimental Investigation)
     
    受賞者: 嶋岡徹*、王岩*、森島真幸*、宮本伸二、小野克重
  • 2014/07 日本不整脈心電学会 第29回日本不整脈学会学術大会・第31回日本心電学会学術集会合同学術大会 Young Investigator's Award
     
    受賞者: 森島 真幸
  • 2013/08 日本病態生理学会 第23回日本病態生理学会大会 特別表彰
     
    受賞者: 森島 真幸
  • 2013/07 第12回九州脳・高血圧・循環制御研究会 最優秀演題賞
     
    受賞者: 森島 真幸
  • 2008/07 第7回九州脳と高血圧研究会 最優秀賞
     
    受賞者: 森島 真幸
  • 2007/11 日本心臓財団 第5回日本心臓財団若年研究者研究奨励（藤基金）
     
    受賞者: 森島 真幸
  • 2007/06 International Society for Heart Research Young Investigator's Award
     
    受賞者: Masaki Morishima
  • 2006/02 徳島大学 康楽賞
     
    受賞者: 森島 真幸
  • 2005/08 徳島大学, 徳島県医師会 第232回徳島医学会 最優秀演題賞
     
    受賞者: 森島 真幸
  • 2001/03 四国大学 芳藍賞
     
    受賞者: 森島 真幸

Research Grants & Projects

  • 日本学術振興会：科学研究費助成事業 基盤研究(C)
    Date (from‐to) : 2020/04 -2023/03 
    Author : 森島 真幸
  • microRNA過剰発現ラットの作製とそれを用いた新しい不整脈発症機序の解明
    日本学術振興会：平成27年度科学研究費助成事業 国際共同研究加速基金
    Date (from‐to) : 2016/04 -2019/03 
    Author : 森島 真幸
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2015/04 -2018/03 
    Author : MORISHIMA Masaki
     
    We have previously shown that miR-30d is up-regulated in cardiomyocytes with persistent atrial fibrillation (AF), in response to cellular Ca2+-overload. It is well-known that abnormal Ca2+ dynamics may lead to the development of AF, however, mechanisms for microRNA-30d (miR-30d） up-regulation in AF cardiomyocytes have not been elucidated. To investigate whether Ca2+ overload regulates miR-30d expression in adult or neonatal rat cardiomyocytes, we infused angiotensin II (Ang II; 1.68 mg/kg/day) or noradrenaline (NA; 5.4 mg/kg/day) for 2 weeks via osmotic minipump into adult Wistar rats, because Ang II and NA are well-known drivers for onset of AF. Acute- or long-term stimulation of cardiomyocytes by Ang II induces elevation of miR-30d expression independently of the changes in blood pressure. The correlation of miR-30d expression between plasma and atrium was positively indicated. Our data would propose circulating miRNA-30d as promise biomarkers and therapeutic targets in AF.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    Date (from‐to) : 2016 -2018 
    Author : MORISHIMA Masaki; Singh Harpreet
     
    Our previous study has shown that microRNA-30d(miR-30d) is up-regulated in cardiomyocytes with persistent atrial fibrillation (AF), in response to cellular Ca2+-overload. However, mechanisms for miR-30d up-regulation in AF cardiomyocytes have not been elucidated. In this study, we investigated the mechanism how microRNA-30d (miR-30d) involved in the development of AF pathogenesis, we established a novel cardio-specific miR-30d overexpressed rat. MiR-30d overexpressed rats showed more vulnerable and short life span compared with wild type rats. The correlation of miR-30d expression between plasma and atrium was positively indicated in those rats. These data proposed circulating miRNA-30d as promise biomarkers and therapeutic targets in AF.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2012/04 -2015/03 
    Author : MORISHIMA Masaki
     
    We established a new animal model called SPORTS rats. The aim of this study was to investigate the role of the L-type Ca2+ channel in cardiomyocytes and its relation with intracellular Ca2+-dependent signalings in cardiac adaptation responding to high physical activity. Injection of Ca2+ channel antagonist verapamil markedly decreased wheel-running activity with a reduction of heart rate in SPORTS rats. In isolated neonatal rat cardiomyocytes from SPORTS rats, spontaneous beating rate, L-type Ca2+ current, and the expression ofits mRNAs were significantly higher than those in control rat. Phosphorylation of CREB and Akt were significantly elevated in SPORTS rat myocytes in the basal condition. These results suggest that phosphorylation of the CREB via activation of PI3K/Akt signaling pathway in SPORTS rats positively regulates the L-type Ca2+ channel expression, which is responsible for the enhancement of physiological hypertrophy and chronotropy in the heart.
  • 運動意欲促進の分子メカニズムの解明
    日本学術振興会：平成21年度科学研究費補助金 若手研究(B)
    Date (from‐to) : 2009/04 -2012/03 
    Author : 森島 真幸
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2010 -2012 
    Author : IWATA Eriko; ONO Katishige; MORISHIMA Masaki
     
    Even though atrial fibrillation is the most commonly encountered clinical arrhythmia,the therapeutic strategy has not been established. Atrial tissue was obtained from patients undergoing cardiovascular surgery using extracorporial circulation. W e identified some ion channels and microRNAs that were down-regulated or up-regulated in atrial fibrillation patients, and suggested it’ s relation to ion channel remodeling and the possibility of therapeutic application.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2009 -2011 
    Author : MORISHIMA Masaki; NAKAYA Yutaka
     
    We established a novel rat strain featured by high levels of voluntary wheel-running, which is called SPORTS(Spontaneously-Running Tokushima-Shikoku) rat. The aim of this study was to investigate the effect of high-or low-intensities in voluntary exercise on sympathetic and vagal controls of heart at sedentary and during wheel-running exercise by use of SPORTS rats. At 15 weeks of age, each rat was moved to a new cage with or without an exercise wheel, and sorted into four groups ; 1) SPORTS rat with an exercise wheel(running), 2) SPORTS rat without an exercise wheel(sedentary), 3) control rat with an exercise wheel(running), and 4) control rat without an exercise wheel(sedentary). Heart rate was significantly increased in sedentary SPORTS rats compared to those in control rats. SPORTS rats show a significant reduction in resting heart rate by high-intensity running. The low frequency/high frequency(LF/HF) ratio, which reflects cardiac sympathetic nerve activity, was significantly decreased in SPORTS rats by voluntary running. However, a decrease of sympathetic nerve activity was not observed in control rats with approximately 1/10 wheel-running activity. By wheel running, the low frequency(LF) power was augmented in control rats, and was markedly depressed in SPORTS rats. High-intensity voluntary running decreases mean heart rate during resting period(sedentary) with a depression of sympathetic nerve activity. These results suggest that high-intensity voluntary exercise attenuates sympathetic nerve activity not only during exercise but also during resting period as a lasting effects.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2007 -2008 
    Author : ONO Katsushige; ONO Katsushige; LEE Tae-seong; ZENG Ming-qi; MORISHIMA Masaki
     
    心筋細胞におけるT型Ca^(2+)チャネルは自動能の形成作用の他はその機能が知られていなかった。本研究は、僅かな細胞膜電位の変化が窓電流形成膜電位に達することでT型Ca^(2+)チャネルを通過するCa^(2+)電流が細胞内Ca^(2+)過負荷を引き起こし、T型Ca^(2+)チャネルが細胞のアポトーシスの引き金として機能することを初めて明らかにした。
  • アンジオテンシンII受容体を介する心筋イオンチャネルremodelingの分子機序の解明
    日本心臓財団：平成19年度日本心臓財団研究奨励第5回日本心臓財団若年研究者研究奨励（藤基金）
    Author : 森島 真幸

Teaching Experience

  • Functional food scienceFunctional food science Kindai University
  • Functional food scienceFunctional food science Kindai University
  • public health nutritionpublic health nutrition Kindai University

Social Contribution

  • コロナ禍がもたらした健康への新たなアプローチ ～身近な食材に存在する天然酵母を観察してみよう～
    Date (from-to) : 2022/10/28
    Role : Appearance
    Category : Visiting lecture
    Sponser, Organizer, Publisher  : 近畿大学農学部
    Event, Program, Title : 近畿大学農学部キャンパス見学会（附属東広島中学校）

Others

  • 2021/08 -2022/03  令和3年度”オール近大”新型コロナウイルス感染症対策支援プロジェクト 研究提案代表者 
    規格外食材を利用したポストコロナ時代の食環境整備
  • 2020/06 -2021/03  令和2年度”オール近大”新型コロナウイルス感染症支援プロジェクト 研究提案代表者 
    「近大ふりかけ」の開発～ウイルスに負けない身体づくり・やる気をアップさせる「ふりかけ」を全国の食卓に～

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