OSHIO Kenichi

Researcher Information

Degree

• D.Sc.（1996/03 Hiroshima University）

J-Global ID

• 200901087020329331

Research Interests

• 非線形動力学   神経科学一般   大脳生理学   Non-linear Dynamics   Neuro Science in General   

Research Areas

• Natural sciences / Mathematical physics and basic theory
• Life sciences / Clinical pharmacy
• Life sciences / Physiology
• Life sciences / Neuroscience - general

Academic & Professional Experience

• 2012 - Today  Kinki University, Faculty of MedicineLecturer
• 2007 - 2012  - 近畿大学医学部 助教
• 1999 - 2007  Kindai UniversityFaculty of Medicine
• 1999 - 2007  Kinki University School of Medicine, Research Associate
• 2007  - Kinki University School of Medicine, Assistant Professor
• 1997 - 1999  Keio University
• 1997 - 1999  Keio University, Research Assistant
• 1996 - 1997  広島大学ナノデバイスシステム研究センター 講師
• 1996 - 1997  Research Center for Nanodevices
• (研究機関研究員)
• Post Doctral Researcher
• and Systems Hiroshima University,

Education

•        - 1996  Hiroshima University  理学研究科  物性学
•        - 1996  Hiroshima University  Graduate School, Division of Natural Science
•        - 1991  Hiroshima University  Faculty of Science  物性学科
•        - 1991  Hiroshima University  Faculty of Science

Association Memberships

• 日本物理学会   日本神経科学会   The Physical Society of Japan   Japan Neuroscience Society   

Published Papers

• Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues

  Atsushi Chiba; Kazunori Morita; Ken‐ichi Oshio; Masahiko Inase

  Scientific Reports 11 17520  2021/09 [Refereed]
  
• Neuronal activity of the monkey prefrontal cortex in a duration estimation and production task

  Chiba A; Morita K; Oshio K; Inase M

  Journal of Physiological Sciences 70 (Supplement 1) S141  2020/03 [Refereed]
  
• Interval timing of visual and auditory cues for duration discrimination in monkey prefrontal cortex

  Chiba A; Morita K; Oshio K; Inase M

  Journal of Physiological Sciences 69 (Supplement 1) S140  2019/03 [Refereed]
  
• Neuronal activity involved in temporal classification in the monkey medial premotor areas

  Chiba A; Oshio K; Inase M

  Journal of Physiological Sciences 68 (Supplement 1) S158  2018/03 [Refereed]
  
• Shared timing-related neuronal activity in prefrontal cortex and medial premotor areas of the monkey

  Chiba A; Oshio K; Inase M

  Journal of Physiological Sciences 67 (Supplement 1) S185  2017/03 [Refereed]
  
• Neuronal activity in the monkey medial premotor areas during a duration classification task

  Chiba A; Oshio K; Inase M

  Journal of Physiological Sciences 66 (Supplement 1) S173  2016/03 [Refereed]
  
• Neuronal representation of duration discrimination in the monkey striatum

  Atsushi Chiba; Ken-Ichi Oshio; Masahiko Inase

  Physiological Reports American Physiological Society 3 (2) e12283  2051-817X 2015 [Refereed]
   

  Functional imaging and lesion studies in humans and animals suggest that the basal ganglia are crucial for temporal information processing. To elucidate neuronal mechanisms of interval timing in the basal ganglia, we recorded single- unit activity from the striatum of two monkeys while they performed a visual duration discrimination task. In the task, blue and red cues of different durations (0.2–2.0 sec) were successively presented. Each of the two cues was followed by a 1.0 sec delay period. The animals were instructed to choose the longer presented colored stimulus after the second delay period. A total of 498 phasically active neurons were recorded from the striatum, and 269 neurons were defined as task related. Two types of neuronal activity were distinguished during the delay periods. First, the activity gradually changed depending on the duration of the cue presented just before. This activity may represent the signal duration for later comparison between two cue durations. The activity during the second cue period also represented duration of the first cue. Second, the activity changed differently depending on whether the first or second cue was presented longer. This activity may represent discrimination results after the comparison between the two cue durations. These findings support the assumption that striatal neurons represent timing information of sensory signals for duration discrimination.
• Possible functions of prefrontal cortical neurons in duration discrimination

  Ken-Ichi Oshio

  Frontiers in Integrative Neuroscience 5 25  1662-5145 2011 [Refereed]
  
• Temporal filtering by prefrontal neurons in duration discrimination

  Ken-ichi Oshio; Atsushi Chiba; Masahiko Inase

  EUROPEAN JOURNAL OF NEUROSCIENCE WILEY-BLACKWELL PUBLISHING, INC 28 (11) 2333 - 2343 0953-816X 2008/12 [Refereed]
   

  Neural imaging studies have revealed that the prefrontal cortex (PFC) participates in time perception. However, actual functional roles remain unclear. We trained two monkeys to perform a duration-discrimination task, in which two visual cues were presented consecutively for different durations ranging from 0.2 to 2.0 s. The subjects were required to choose the longer cue. We recorded single-neuron activity from the PFC while the subjects were performing the task. Responsive neurons for the first cue period were extracted and classified through a cluster analysis of firing rate curves. The neuronal activity was categorized as phasic, ramping and sustained patterns. Among them, the phasic activity was the most prevailing. Peak time of the phasic activity was broadly distributed about 0.8 s after cue onset, leading to a natural assumption that the phasic activity was related to cognitive processes. The phasic activity with constant delay after cue onset might function to filter current cue duration with the peak time. The broad distribution of the peak time would indicate that various filtering durations had been prepared for estimating C1 duration. The most frequent peak time was close to the time separating cue durations into long and short. The activity with this peak time might have had a role of filtering in attempted duration discrimination. Our results suggest that the PFC contributes to duration discrimination with temporal filtering in the cue period.
• Effects of isotonic contraction excised vas deferens of guinea-pigs under pain-related drugs

  千葉 惇; 生塩 研一; 稲瀨 正彦

  Biomagnetism interdisciplinary reserch and exploration 275 - 277 2008/08 [Refereed]
   

  単離したモルモット輸精管へ発痛物質（カプサイシン、ホルマリン）を投与した際の静磁場の効果を調べた。
• Striatal neurons encoded temporal information in duration discrimination task

  Atsushi Chiba; Ken-ichi Oshio; Masahiko Inase

  EXPERIMENTAL BRAIN RESEARCH SPRINGER 186 (4) 671 - 676 0014-4819 2008/04 [Refereed]
   

  To clarify the roles of the basal ganglia in time perception, single-unit activity was recorded from both sides of the striatum of a monkey performing a duration discrimination task. In the task, two visual cues were presented successively in different durations (0.2 similar to 1.6 s). Each cue presentation was followed by a 1-s delay period. The subject was instructed to choose a longer presented cue after the second delay period. There were two types of trials for sequence of cue duration, the long-short (LS) trials in which the first cue (C1) was longer than the second cue (C2) and the short-long (SL) trials in which the C1 was shorter than the C2. Striatal neurons phasically responded during the first delay (D1) and second delay (D2) periods. Responses during the D1 period changed depending on C1 duration. Activity of populations of D1-response neurons correlated with C1 duration positively or negatively. Responses during the D2 period differed between the LS and SL trials. Activity of population of D2-response neurons also changed depending on C2 duration. But the dependence on C2 duration was affected by the trial type, that is, whether the C2 was longer or shorter compared to the C1.These findings suggest that striatal neurons could encode cue durations with monotonically changing responses in the D1 period and discrimination results between the two cue durations in the D2 period.
• Prophylactic effect of repetitive magnetic stimulation against stroke in malignant stroke-prone spontaneously hypertensive rats

  千葉 惇; 生塩 研一; 稲瀨 正彦

  The Journal of Japan Biomagnetism and Bioelectromagnetics Society 日本生体磁気学会 19 (1) 258 - 259 2006/06 [Refereed]
   

  高血圧症モデルラット(M-SHRSP)の脳及び脊髄へパルス磁気刺激を与えた。血圧上昇は押さえられなかったが、脳卒中発症抑制効果が観察された。
• Delay period activity of monkey prefrontal neurones during duration-discrimination task

  Ken-ichi Oshio; Atsushi Chiba; Masahiko Inase

  EUROPEAN JOURNAL OF NEUROSCIENCE WILEY 23 (10) 2779 - 2790 0953-816X 2006/05 [Refereed]
   

  Evidence from brain imaging studies has indicated involvement of the prefrontal cortex (PFC) in time perception; however, the role of this area remains unclear. To address this issue, we recorded single neuronal activity from the PFC of two monkeys while they performed a duration-discrimination task. In the task, two visual cues (a blue or red square) were presented consecutively followed by delay periods and subjects then chose the cue presented for the longer duration. Durations of both cues, order of cue duration [long-short (LS) or short-long (SL)] and order of cue colour (blue-red or red-blue) were randomized on a trial-by-trial basis. We found that subjects responded differently between LS and SL trials and that most prefrontal neurones showed significantly different activity during either the first or the second delay period when comparing activity in LS and SL trials. The present result offers new insights into neural mechanisms of time perception. It appears that, during the delay periods, the PFC contributes to implement a strategic process in temporal processing associated with a trial type (LS or SL) such as representation of the trial type, retention of cue information and anticipation of the forthcoming cue.
• Neuronal activity in the monkey striatum during a duration discrimination task

  Atsushi Chiba; Ken-ichi Oshio; Masahiko Inase

  Neuroscience 2005, 35th Annual Meeting of Society for Neuroscience, Washington DC, USA Program No. 413.5 2005 [Refereed]
  
• 1SD54 Neural mechanisms of time perception in monkey brain

  Oshio K.

  Seibutsu Butsuri The Biophysical Society of Japan General Incorporated Association 45 S14  2005
• A trial of the objective structured skill examination in PBL tutorial course

  松尾 理; 稲瀨 正彦; 村田 哲; 千葉 惇; 生塩 研一; 岡田 清孝; 上嶋 繁

  Journal of Medical Education 7 (4) 73 - 75 2004/08 

  PBL テュートリアルコースでの学生実習の客観的技能試験を行った。（英文）
• Neural mechanism for time perception in dorsolateral prefrontal cortex using duration-discrimination task

  4th Forum of European Neuroscience 2004 [Refereed]
  
• Analysis of neuronal network of C. elegans by using database of synaptic connectivity for computation

  Kawamura K; Oshio K; Iwasaki Y; Morita S; Osana Y; Gomi S; Akiyama E; Omata K; Matsuura T; Oka K

  SfN Neuroscience 2004, Program No. 658.3 2004 [Refereed]
  
• Neuron classification based on temporal firing patterns by the dynamical analysis with changing time resolution (DCT) method

  Ken-Ichi Oshio; Satoshi Yamada; Michio Nakashima

  Biological Cybernetics 88 (6) 438 - 449 0340-1200 2003/06 [Refereed]
   

  Spike train data of many neurons can be obtained by multirecording techniques however, the data make it difficult to estimate the connective structure in a large network. Neuron classification should be helpful in that regard, assuming that multiple neurons having similar connections with other neurons show a similar temporal firing pattern. We propose a novel method for classifying neurons based on temporal firing patterns of spike train data called the dynamical analysis with changing time resolution (DCT) method. The DCT method can evaluate temporal firing patterns by a simple algorithm with few arbitrary factors and automatically classify neurons by similarity of temporal firing patterns. In the DCT method, temporal firing patterns were objectively evaluated by analyzing their dependence on temporal resolution. We confirmed the effectiveness of the DCT method using actual spike train data.
• Motor evoked potentials in rats with congenital hydrocephalus

  Atsushi Chiba; Yoshio Ohta; Ken-Ichi Oshio; Masahiko Inase

  Neurological Research 25 (3) 305 - 308 0161-6412 2003/04 [Refereed]
   

  Motor evoked potential (MEP) by focal transcranial magnetic stimulation was used to test the functional integrity of the motor cortex in congenital hydrocephalic rats. Magnetic MEPs, using a figure-eight coil above the head, were recorded in the tibialis anterior muscle. The latency of transcranial magnetic MEP was 3.4 msec in nonhydrocephalic rats. In the hydrocephalic rats, the MEP had a lower threshold than in nonhydrocephalic rats, and showed two peaks. Latencies of early and late peaks were 3.9 msec and from 5.4 msec to 10.0 msec, respectively. Our findings suggest that hydrocephalus in rats is associated with changes in pyramidal cell excitability in the motor cortical area, probably induced by the fluctuations in cortical excitability and synaptic interaction in hydrocephalic rats.
• Neuronal activity in monkey dorsolateral prefrontal cortex during duration-discrimination task

  Ken-ichi Oshio; Atsushi Chiba; Masahiko Inase

  Sixth IBRO World Congress of Neuroscience, July 10-15, 2003, Prague, Czech Republic. 2003 [Refereed]
  
• Neuronal Circuit and Native Responses of C. elegans "jointly worked"

  14th biennial International C. elegans, June 29 - July 3, 2003, California, USA 2003 [Refereed]
  
• A trial of the objective structured skill examination in PBL tutorial course

  Matsuo O; Inase M; Murata A; Chiba A; Oshio K; Okada K; Ueshima S

  Journal of Medical Education 7 (4) 73 - 75 2003 [Refereed]
  
• Magnetically evoked EMGs in rats

  A Chiba; K Oshio; M Inase

  NEUROLOGICAL RESEARCH FOREFRONT PUBL GROUP 25 (1) 87 - 91 0161-6412 2003/01 [Refereed]
   

  Magnetic stimulation of the brain and spinal cord was carried out in rats to record electromyogram (EMGs) from the gastrocnemius. A figure-eight coil was set over the middle of the dorsum, and shifted from the cervical vertebrae to the sacrum. The motor evoked potentials (MEPs) with 4.8 msec latency by transcranial magnetic stimulation and the descending wave with 4.7 msec latency by C3-C4 stimulation were recorded. In evoked EMGs by magnetic stimulation over T9-T10, L4-L5, S2-S3 and Ca2-Ca3 spinal cord levels, the causes of these two evoked components with short (1.5 msec) and long (4.1 msec) latencies were estimated to be the eddy current generated from the rostral to the caudal portion of the spinal cord. With the increase in magnetic stimuli, the relative sizes and disappearance of H- and M-like responses were comparable with the ordinary M- and H-responses in electrically evoked EMGs. The magnetic stimulation of the spinal cord activated the sciatic nerve at their vertebral exit, because the latencies of the H- and M-responses were constant despite the changing stimulus sites. Although magnetic stimulation with the figure-eight coil can be focused on the target, it is necessary to take into consideration the influence of the eddy current flowing in the body. [Neurol Res 2003; 25: 87-91].
• Geometrical structure of the neuronal network of Caenorhabditis elegans

  S Morita; K Oshio; Y Osana; Y Funabashi; K Oka; K Kawamura

  PHYSICA A ELSEVIER SCIENCE BV 298 (3-4) 553 - 561 0378-4371 2001/09 [Refereed]
   

  The neuronal network of the soil nematode Caenorhabditis elegans (C. elegans), which is a good prototype for biological studies, is investigated. Here, the neuronal network is simplified as a graph. We use three indicators to characterize the graph; vertex degree, generalized eccentricity (GE), and complete subgraphs. The graph has the central part and the strong clustering structure. We present a simple model, which shows that the neuronal network has a high-dimensional geometrical structure. (C) 2001 Elsevier Science B.V. All rights reserved.
• Native response of C-elegans encoded in its neuron network

  Y Funabashi; K Kawamura; K Oshio; S Morita; Y Osana; E Akiyama; K Oka

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN PHYSICAL SOC JAPAN 70 (4) 1154 - 1161 0031-9015 2001/04 [Refereed]
   

  For the physical study of the native responses of Caenorhabditis elegans (C. elegans), probability distribution of random walkers on the neuron graph is studied. Here, the neuron graph is a graph which represents the synaptic connection of neurons of the worm. Connection of a sensory neuron to various motor neurons are represented by an index named accessibility. Accessibilities from 39 sensory neurons to all of motor neurons are computed and the formers are classified into three groups. It is found that this classification coincides with the grouping by native responses caused by those sensory neurons. This coincidence implies the usefulness of the random walker model for the analysis of the neural network. The connectivity represented by the major paths of random walkers is a significant factor to interpret relation between external disturbance and resultant movement in the native response of the worm. This native response of the worm is encoded by the connectivity of vertices in the neuron graph.
• Does a randomly organized electrical circuit function as a neuronal system?

  K Kawamura; Y Funabashi; S Morita; K Omata; K Oshio; Y Osana; K Oka

  JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS INST PURE APPLIED PHYSICS 40 (3B) 2095 - 2099 0021-4922 2001/03 [Refereed]
   

  It is argued that a randomly fabricated electric circuit functions as an information processor. Indeed, the neuronal system of Caenorhabditis elegans (C. elegans) is a random network which processes various information for the survival of the worm. After properties of the connectivity of the neuronal system of the worm are reviewed to emphasize its randomness, it is confirmed that a network of resistors, which is topologically homologous to the neuronal network of C. elegans, can encode a decision table which is similar to the decision table of the native responses of the worm. Some structural properties, which are advantageous for the functioning of a random resistor network for an information processor, are discussed. In addition, it is suggested that a network of resistors with these propeties is a bundle of intertwisted wires connected by some resistive particles.
• Simulational study on neural network of C. elegans(CCE Program)(]G0001[)

  54th Annual Meeting. The Physical Society of Japan, 1999 1999 [Refereed]
  
• Analysis of Neural Connectivity of C.elegans using Random walker(jointly worked)

  12th International C.elegans Meeting 1999 [Refereed]
  
• Excitatory and inhibitory pathways in neural network of C. elegans for touch-induced movement

  Iwasaki Y.; Gomi S.; Osana Y.; Oshio K.; Morita S.; Oka K.

  Seibutsu Butsuri The Biophysical Society of Japan General Incorporated Association 39 S63  0582-4052 1999
• Activity-dependent staining of neural circuits for avoidance reflex in C. elegans

  Oka K.; Fukada M.; Shimizu R.; Ogawa H.; Oshio K.; Morita S.; Osana Y.; Kawamura K.

  Seibutsu Butsuri The Biophysical Society of Japan General Incorporated Association 39 S63  0582-4052 1999
• Bifurcation and chaos of current oscillations in semiconductors with NDC

  K Oshio

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN PHYSICAL SOC JAPAN 67 (7) 2538 - 2545 0031-9015 1998/07 [Refereed]
   

  This paper describes a simulational study on bifurcation and chaos of current oscillations in semiconductor with NDC (Negative Differential Conductivity) induced by the recombination instability. A one-dimensional model of gold-doped n-Ge has been proposed in which the recombination instability leads the system to instability and current oscillations, and the computations have been performed under the boundary conditions with d.c. bias. We found that this system exhibits complicated structure of bifurcations for current oscillations including chaotic behavior and unusual truncated branches on bifurcation diagrams at the transition region between two basic oscillation modes in the parameter space.
• Analysis of spike trains from Aplysia abdominal ganglia neurons

  36th Annual Meeting. The Biophysical Society of Japan, 1998 1998 [Refereed]
  
• Simulational Study on Sb Pile-up at Si/SiO₂ Interface

  Ken-ichi Oshio; Kentaro Shibahara

  The 44th Spring Meeting, 1997 ; The Japan Society of Applied Physics and Related Societies 1997 [Invited]
  
• High-field domains and Chaotic Current Oscillations in Semiconductor with NDC

  Ken-ichi Oshio

  TECHNICAL REPORT OF IEICE ED96 (210) 9 - 16 1997 [Refereed][Invited]
  
• Current oscillations induced by recombination instability in semiconductors

  K Oshio; H Yahata

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN PHYSICAL SOC JAPAN 65 (5) 1490 - 1499 0031-9015 1996/05 [Refereed]
   

  We present a one-dimensional system of gold-doped n-Ge in which the recombination instability leads the system to instability and current oscillations. Using the finite difference method, spatio-temporal evolution of the high-field domain is computed with the bias voltage, the recombination coefficient, and the emission coefficient being taken as the control parameters. Three types of modes of operation: the Ohmic, the quenched and the transit-time modes are found. Non-periodic oscillations are also found in the transition region between the quenched and the transit-time modes. Their origins are clarified on the basis of spatio-temporal evolution of the high-field domain.
• NONPERIODIC CURRENT OSCILLATIONS IN THE GUNN-EFFECT DEVICE WITH THE IMPACT-IONIZATION EFFECT

  K OSHIO; H YAHATA

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN PHYSICAL SOC JAPAN 64 (5) 1823 - 1836 0031-9015 1995/05 [Refereed]
   

  A simulation model of the Gunn-effect device is considered. Using the finite difference method, spatio-temporal evolution of the system in the presence of the impact-ionization effect in the device is computed for n-GaAs with the recombination rate and the bias voltage being taken as the control parameters. We thereby show the motion of the Gunn-effect device exhibits non-periodic behavior due to its own autonomous nonlinearity even if it is not driven by an external periodic field. The domain motion is perturbed by the carrier generation due to the impact ionization, and it becomes non-periodic for specially chosen model parameters. It also exhibits the interpulse incoherent current oscillations similar to the ones observed experimentally. Some remarks are given on the mechanism giving rise to the nonperiodicity on the basis of spatio-temporal evolution of the high-field domain.
• CHAOTIC CURRENT OSCILLATIONS IN THE GUNN-EFFECT DEVICE UNDER THE DC AND THE RF BIAS VOLTAGES

  K OSHIO; H YAHATA

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN PHYSICAL SOC JAPAN 62 (10) 3639 - 3650 0031-9015 1993/10 [Refereed]
   

  A one-dimensional model system of the Gunn-effect device is considered. It consists of an n+-n-n+ GaAs sandwich structure where the high-n+ contact layers on both ends are linearly graded to the uniformly distributed low-n bulk region and a half-wave sinusoidal doping notch is incorporated near the cathode. Using the finite differece method, spatio-temporal evolution of the system subject to the dc and the rf-alternating fields is computed with the amplitudes and the frequency being taken as the control parameters. Current oscillations associated with the cyclic traveling high-electric-field domain are shown to materialize over a range of the control parameters. In particular, the current oscillations become chaotic at specially chosen values of these bias parameters.

Conference Activities & Talks

• 時間知覚と生成におけるサル前頭前野と内側運動前野の機能連関  [Not invited]

  千葉惇; 守田和紀; 生塩研一; 稲瀬正彦

  NEURO 2022 第45回日本神経科学大会  2022/07
• Integration of temporal information on auditory and visual stimuli in monkey prefrontal neurons  [Not invited]

  千葉惇; 守田和紀; 生塩研一; 稲瀬 正彦

  第99回日本生理学会大会  2022/03
• Cue response properties of monkey striatal neurons during duration discrimination task  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  Neuro 2010 （第３３回日本神経科学大会）  2010/09  神戸  Neuro 2010 （第３３回日本神経科学大会）
   

  時間弁別課題中のサル線条体の手がかり期の神経細胞の活動特性を調べた．
• Response properties of monkey striatal neurons during a duration discrimination task  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第８７回日本生理学会大会  2010/05  盛岡  第８７回日本生理学会大会
   

  時間弁別課題中のサル線条体ニューロンのユニット解析し、その特性を調べた．
• Physiological effects of the upright sitting on the knees  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  36th International congress of physiological sciences  2009/07  京都  36th International congress of physiological sciences
   

  正座中の重心動揺、下肢の皮膚温、血圧の変動を調べた。（英文）
• Effects of isolated crayfish heart by pulsed magnetic stimulation  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  日本生体磁気学会  2009/05  金沢  日本生体磁気学会
   

  摘出したザリガニの心臓を用いてパルス磁気刺激の効果を調べた。心臓の収縮パターンは、パルス磁気刺激と同期した。
• 時間弁別課題におけるサル前頭前野の機能的役割  [Not invited]

  生塩 研一; 千葉 惇; 稲瀨 正彦

  日本物理学会第64回年次大会  2009/03  東京  日本物理学会第64回年次大会
  
• Analgesia effects of static magnetic fields on muscular contraction  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第3回日本磁気科学学会年次大会  2008/10  弘前  第3回日本磁気科学学会年次大会
   

  モルモット輸精管の筋収縮を指標とし、発痛物質投与後の静磁場による効果を調べた。
• Effects of isotonic contraction excised vas deferens of guinea-pigs under pain-related drugs  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  16th International conference on Biomagnetism  2008/08  札幌  16th International conference on Biomagnetism
   

  モルモット輸精管を用いて発痛物資投与中の静磁場の影響を調べた。
• Monkey striatal neurons encoded temporal information in duration discrimination task  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第31回日本神経科学大会  2008/07  東京  第31回日本神経科学大会
   

  時間弁別課題中のサル線条体からユニットを記録し時間処理について解析した。
• Learning of leg position in crayfish with magnetic stimulation  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第23回日本生体磁気学会  2008/06  東京  第23回日本生体磁気学会
   

  ザリガニ歩脚位置学習における磁気刺激と電気刺激の効果を比較した。
• Learning of leg position in crayfish using magnetic stimulation  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第85回日本生理学会大会  2008/03  東京  第85回日本生理学会大会
   

  アメリカザリガニの第１歩脚を用いて磁気刺激によるザリガニの歩脚位置学習を試みた。
• Cue-period activity of monkey prefrontal neurons during a duration-discrimination task  [Not invited]

  生塩 研一; 千葉 惇; 稲瀨 正彦

  第30回日本神経科学大会  2007/09  横浜市  第30回日本神経科学大会
  
• Modulation of magnetically evoked H-reflex after moxibustion  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第22回日本生体磁気学会  2007/06  岡崎  第22回日本生体磁気学会
   

  ラット脊椎L4-L5へ間接灸を施救後に磁気誘発筋電図を腓腹筋から導出し、施灸による促通効果を見い出した。
• Prophylactic effect of repetitive pulsed magnetic stimulation against stroke in malignant stroke-prone spontaneously hypertensive rats (M-SHRSP)  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第2回日本磁気科学学会年次大会  2007/06  大阪  第2回日本磁気科学学会年次大会
   

  連続パルス磁気刺激をM-SHRSPの脳脊髄へ２日ごとに誘発電位の閾値の1.２倍の強度を与えた結果、脳卒中を抑制し延命効果が観測された。
• Effects of transcranial magnetic stimulation on H-reflex in rats  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第84回日本生理学学会大会  2007/03  大阪  第84回日本生理学学会大会
   

  ラットに８字コイルを用いて経頭蓋的磁気刺激を与え、H反射の影響を調べた。
• Prophylactic effect of repetitive magnetic stimulation against stroke in malignant stroke-prone spontaneously hypertensive rats (M-SHRSP)  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第28回日本比較生理性化学学会  2006/12  浜松  第28回日本比較生理性化学学会
   

  M-SHRSPへ経頭蓋的磁気刺激を試みたところ、脳卒中抑制効果を見い出した。
• Delay period activity of the monkey striatum in duration discrimination task  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第29回日本神経科学大会  2006/07  京都  第29回日本神経科学大会
   

  時間弁別課題遂行中のサル線条体から遅延期のユニットを記録した。
• Prophylactic effect of repetitive magnetic stimulation against stroke in malignant stroke-prone spontaneously hypertensive rats  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  日本生体磁気学会  2006/06  大阪  日本生体磁気学会
   

  高血圧症モデルラット(M-SHRSP)を用いて低頻度パルス磁気刺激を脳及び脊髄へ与えることにより血圧降下とそれに伴う脳卒中抑制効果を調べた。
• Prophylactic effect and detection against stroke by magnetic stimulation  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第８３回日本生理学会大会  2006/03  前橋  第８３回日本生理学会大会
   

  磁気刺激法によるM-SHRSPのM-SHRSPの脳卒中発症の予防と病変の検出を試みた。（英文）
• Detection of rat spinal cord injuries by magnetic stimulation  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦; 梶本禮義

  第２０回日本生体磁気学会  2005/07  大阪  第２０回日本生体磁気学会
   

  パルス磁気刺激を用いてラットの脊髄損傷部位の検出を試みた。病変部位の検出には有効であったが、その部位の特定には工夫が必要である。
• Neuronal modulation in the monkey striatum related to duration discrimination task  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第２８回日本神経科学大会  2005/07  横浜  第２８回日本神経科学大会
   

  時間弁別課題中のサル線条体からの神経細胞活動を記録し、時間弁別に関連して発火するニューロンの特徴を報告した。
• Phasic neuronal activity in the monkey striatum during duration discrimination task  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第８２回日本生理学会大会  2005/05  仙台  第８２回日本生理学会大会
   

  時間弁別課題中のサル線条体からのユニットを記録し、時間弁別に関連するニューロンの特性を調べた。
• The development of the objective strucured skill examination in Physiology education  [Not invited]

  松尾 理; 稲瀨 正彦; 村田 哲; 千葉 惇; 生塩 研一; 岡田 清孝; 上嶋 繁

  XXXV International Congress of Physiological Sciences  2005/04  San Diego  XXXV International Congress of Physiological Sciences
   

  生理学教育における実習を効果的にするため学生の技能を客観的に評価する方法を開発した。（英文）
• 時間弁別課題中のサル線条体ニューロン活動  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  脳と心のメカニズム第5回冬のワークショップ  2005/01  留寿都  脳と心のメカニズム第5回冬のワークショップ
   

  サル線条体から時間弁別課題中のニューロン活動を記録した。
• 時間弁別課題遂行中のサル前頭前野の神経活動  [Not invited]

  生塩 研一; 千葉 惇; 稲瀨 正彦

  平成１６年度生理学研究所研究会  2005/01  岡崎市  平成１６年度生理学研究所研究会
  
• Neuronal activity in the monkey striatum during a duration discrimination task  [Not invited]

  Neuroscience 2005, 35th Annual Meeting of Society for Neuroscience, Washington DC, USA  2005
• サルを用いた時間認知に関わる神経機構の解明  [Invited]

  日本生物物理学会第43回年会シンポジウム「神経回路の情報生物物理学」  2005
• Neural mechanisms of monkey prefrontal cortex for time perception  [Not invited]

  生塩 研一; 千葉 惇; 稲瀨 正彦

  日本生物物理学会第42回年会  2004/12  京都市  日本生物物理学会第42回年会
  
• Effects of static magnetic field for muscular contraction by pain  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第27回日本神経科学学会大会  2004/11  大阪  第27回日本神経科学学会大会
   

  痛み物質投与後の平滑筋収縮に対する静磁場の影響を調べた。
• Functional roles of prefrontal cortex in time perception  [Not invited]

  生塩 研一; 千葉 惇; 稲瀨 正彦

  脳と心のメカニズム第5回夏のワークショップ  2004/08  新潟湯沢  脳と心のメカニズム第5回夏のワークショップ
  
• Anatomical data of synaptic connectivity of C. elegans are almost perfectly self-contained  [Not invited]

  川村 清; 生塩 研一; 岩崎 唯史; 守田 智; 長名 優子; 五味 壮平; 尾又 一実; 秋山 英三

  2004 East Asia Worm Meeting  2004/07  淡路  2004 East Asia Worm Meeting
  
• Relation of magnetically evoked EMGs and the spinal vascular lesions in M-SHRSP  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  2004/06 

  M-SHRSP
• Delay period activity fo dorsolateral prefrontal cortex during duration-discrimination task  [Not invited]

  生塩 研一; 千葉 惇; 稲瀨 正彦

  The 31st NIPS International Symposium, Multidisciplinary Approaches to Sensorimotor Integration  2004/03  The 31st NIPS International Symposium, Multidisciplinary Approaches to Sensorimotor Integration
  
• Neural mechanism for time perception in dorsolateral prefrontal cortex using duration-discrimination task  [Not invited]

  4th Forum of European Neuroscience  2004
• Analysis of neuronal network of C. elegans by using database of synaptic connectivity for computation  [Not invited]

  SfN Neuroscience 2004, Program No. 658.3  2004
• サル前頭前野において時間弁別に関わる神経活動  [Not invited]

  第２７回に本神経科学大会, P3-313  2004
• C. elegansの新しい神経回路データベース  [Not invited]

  日本物理学会第５９回年次大会  2004
• Effects of static magnetic field on the smooth muscle contraction by capsaicin pain model  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第25回日本比較生理生化学学会  2003/11  仙台  第25回日本比較生理生化学学会
  
• C. elegans神経回路網のクラスター構造と機能  [Not invited]

  川村 清; 生塩 研一; 船橋 靖広; 岡; 尾又 一実; 守田 智; 長名 優子

  日本物理学会2003年秋季大会  2003/09  岡山市  日本物理学会2003年秋季大会
  
• Behavioral characteristics during duration-discrimination task in the monkey  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第26回日本神経科学学会  2003/07  名古屋  第26回日本神経科学学会
   

  サルに時間弁別課題をした時の行動解析をした。
• The relation between pain and magnetic field in smooth muscle contraction  [Not invited]

  千葉 惇; 生塩 研一; 村田 哲; 梶本 のり義; 稲瀨 正彦

  第80回日本生理学会大会  2003/03  福岡  第80回日本生理学会大会
   

  モルモット輸精管の平滑筋を用いて、痛み物資投与後の筋収縮に対しての静磁場暴露の影響を調べた。
• Neuronal activity in monkey dorsolateral prefrontal cortex during duration-discrimination task  [Not invited]

  Sixth IBRO World Congress of Neuroscience, July 10-15, 2003, Prague, Czech Republic.  2003
• Neuronal Circuit and Native Responses of C. elegans (共著)  [Not invited]

  14th biennial International C. elegans, June 29 - July 3, 2003, California, USA.  2003
• 時間弁別課題遂行中の前頭前野背外側部ニューロンの応答  [Not invited]

  第２６回日本神経科学大会, ７月, 名古屋, P2-P-155.  2003
• 株式市場日中変動における離散的時系列の時間パターン分類法  [Not invited]

  第３回統数研／第１２回総研大「経済学」研究会，東京，３月  2003
• PBL trial of the objective structured skill examination (OSSE) in PBL tutorial course  [Not invited]

  松尾 理; 岡田 清孝; 上嶋 繁; 稲瀨 正彦; 村田 哲; 千葉 惇; 生塩 研一

  The 3rd Asian-Pacific Conference on PBL in Health Sciences  2002/11  Taipei  The 3rd Asian-Pacific Conference on PBL in Health Sciences
   

  統合カリキュラムで集中したコースの中で学生実習をいかに客観的評価するかを検討し報告した。（英文）
• Effects of static magnetic field on the response of the isolated guinea pig vas deferens by capsaicin  [Not invited]

  千葉 惇; 生塩 研一; 村田 哲; 稲瀨 正彦

  第13回日本比較生理生化学学会大会  2002/08  つくば  第13回日本比較生理生化学学会大会
   

  静磁場下のモルモット輸精管の平滑筋の収縮状態を観察した。
• Revision of synaptic connectivity database  [Not invited]

  生塩 研一; 守田 智; 長名 優子; 岩崎 唯史; 五味 壮平; 尾又 一実; 秋山 英三; 岡 浩太郎

  The third japanese C. elegans meeting  2002/08  名古屋市  The third japanese C. elegans meeting
  
• Pathways from sensory neurons to motor neurons determined by McCulloch-Pitts algorithm  [Not invited]

  川村 清; 生塩 研一; 岡 浩太郎; 守田 智; 長名 優子

  The third C. elegans meeting  2002/08  名古屋市  The third C. elegans meeting
  
• Effects of magnetic field on the response of the isolated guinea pig vas deferens by capsaicin  [Not invited]

  千葉 惇; 生塩 研一; 村田 哲; 稲瀨 正彦

  第25回日本神経科学大会  2002/07  東京  第25回日本神経科学大会
   

  経壁的電気刺激によるモルモット輸精管の平滑筋収縮において、静磁場とカプサイシンの影響を観察した。
• Fatigue in muscular contraction caused by magnetic stimulation  [Not invited]

  千葉 惇; 生塩 研一; 村田 哲; 稲瀨 正彦

  第17回日本生体磁気学会大会  2002/05  静岡  第17回日本生体磁気学会大会
   

  同じ重量負荷下におけるカエル縫工筋を用いて、電気ならびに磁気刺激により惹起した筋収縮時の高エネルギーリン酸化代謝物を３１P-NMRにより測定しその筋疲労度を調べた。
• Objective structured skill examination in phygiological student practice  [Not invited]

  松尾 理; 深尾偉晴; 岡田 清孝; 上嶋 繁; 稲瀨 正彦; 村田 哲; 千葉 惇; 生塩 研一

  第７９回日本生理学会大会  2002/03  広島  第７９回日本生理学会大会
   

  生理学実習において客観的技能試験を実施し、実習試験（筆答）およびコース統合成績と比較検討した。
• Effects of magnetic stimulation on the response of the isolated guinea pig vas deferens  [Not invited]

  千葉 惇; 生塩 研一; 村田 哲; 稲瀨 正彦

  第79回日本生理学大会  2002/03  広島  第79回日本生理学大会
   

  摘出平滑筋の収縮における静磁場の影響を調べた。
• C. elegansの感覚ニューロンから運動ニューロンへのaccessibility  [Not invited]

  川村 清; 生塩 研一; 岡 浩太郎; 守田 智; 長名 優子

  日本物理学会第57回年次大会  2002/03  滋賀県草津市  日本物理学会第57回年次大会
  
• 時間パターンによる離散的時系列分類法（DCT法）  [Not invited]

  生塩 研一

  異分野研究者交流フォーラム バイオインフォマティクス- in silico生物学への展望-  2002/03  静岡県田方郡大仁町  異分野研究者交流フォーラム バイオインフォマティクス- in silico生物学への展望-
  
• Pituitary vascular casts in hypertensive model rats  [Not invited]

  千葉 惇; 太田 善夫; 生塩 研一; 村田 哲; 稲瀨 正彦

  第２４回日本神経科学学会大会  2001/11  京都  第２４回日本神経科学学会大会
   

  高血圧症モデルラット（WKY, SHR, SHRSP, M-SHRSP）の脳下垂体の血管鋳型像を作製し、SEMにて観察・比較した。
• 土壌線虫C. elegans神経回路網の構造と機能  [Not invited]

  尾又 一実; 生塩 研一; 守田 智; 長名 優子; 船橋 靖広; 岡; 浩太郎; 川村 清

  第10回日本バイオイメージング学会学術集会  2001/10  東京都  第10回日本バイオイメージング学会学術集会
  
• Magnetically evoked EMGｓ in congenital hydrocephalus SHR  [Not invited]

  千葉 惇; 太田 善夫; 生塩 研一; 村田 哲; 稲瀨 正彦

  第16回日本生体磁気学会大会  2001/06  東京  第16回日本生体磁気学会大会
   

  SHRから系統分離された先天性水頭症ラットの磁気誘発筋電図を観察した。
• DCT法による時間パターン類似性に基づいた離散的時系列分類  [Not invited]

  生塩 研一; 山田 訓; 中島 道夫

  オープンダイナミックスの諸相 研究会  2001/06  横浜市  オープンダイナミックスの諸相 研究会
  
• Effects of magnetic stimulation on the smooth muscle contraction  [Not invited]

  千葉 惇; 生塩 研一; 村田 哲; 稲瀨 正彦

  第１２回日本比較生理生化学大会  2001/05  福岡  第１２回日本比較生理生化学大会
   

  モルモット輸精管の平滑筋を標本とし、磁気刺激およびカルシウム拮抗剤など投与後の平滑筋の収縮特性を調べた。
• Scanning microscopy of gastric vascular casts in hypertensive rats  [Not invited]

  千葉 惇; 生塩 研一; 村田 哲; 稲瀨 正彦

  第78回日本生理学会大会  2001/03  京都  第78回日本生理学会大会
   

  高血圧症モデルラット（WKY, SHR, SHRSP, M-MSRSP）の胃血管鋳型を作製しSEMで観察した。
• Impact spinal cord injury on magnetically evoked EMGｓ  [Not invited]

  千葉 惇; 生塩 研一; 太田 善夫; 稲瀨 正彦; 島田 洋一

  第23回日本神経科学学会  2000/11  横浜  第23回日本神経科学学会
   

  インパクト損傷装置によりラット脊髄損傷を作製し、損傷度と磁気誘発筋電図との関係を調べた。
• The necessary factor for muscle contraction by magnetic stimulation  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  日本比較生理生化学学会  2000/11  山口  日本比較生理生化学学会
   

  磁気刺激による筋収縮には、終板におけるシナプス前膜の状態に依存していることを明らかにした。
• Analysis on excitatory and inhibitory pathways in neural network of C. elegans III  [Not invited]

  岩崎 唯史; 生塩 研一; 五味 壮平; 守田 智; 長名 優子; 岡; 浩

  日本物理学会第55回年次大会  2000/09  新潟市  日本物理学会第55回年次大会
  
• Neuron classification based on firing pattern with "Dynamical analysis with changing time resolution (DCT) method" from multi-channel recording data  [Not invited]

  生塩 研一; 千葉 惇; 稲瀨 正彦; 山田 訓; 中島

  第23回日本神経科学大会  2000/09  横浜市  第23回日本神経科学大会
  
• Classification of neurons with dynamical analysis with changing time resolution (DCT) method from multi-channel recording data  [Not invited]

  生塩 研一; 稲瀨 正彦; 山田 訓; 中島

  CRESRシンポジウム「脳を創る」  2000/07  東京都港区  CRESRシンポジウム「脳を創る」
  
• Prediction of brain and spinal cord damages in M-SHRSP by magnetically evopked EMGｓ  [Not invited]

  千葉 惇; 太田 善夫; 生塩 研一; 稲瀨 正彦

  日本生体磁気学会  2000/05  東京  日本生体磁気学会
   

  M-SHRSPを用いて神経系の病変と磁気誘発筋電図との関係を調べた。
• Changes in spinal cord function caused by injuries at different levels of the lumbar spinal cord  [Not invited]

  千葉 惇; 蛭間 慎吾; 橋本 重夫; 生塩 研一; 稲瀨 正彦

  日本生体磁気学会  2000/05  東京  日本生体磁気学会
   

  ラット脊髄損傷部位が、腰椎上位と腰椎下位レベルの場合の磁気誘発筋電図を比較・検討した。
• Numerical study on excitatory and inhibitory pathways in neural network of C. elegans  [Not invited]

  岩崎 唯史; 生塩 研一; 五味 壮平; 長名 優子; 岡; 守田 智

  Third east asian biophysics symposium EABS 2000  2000/05  Kyongju, Korea  Third east asian biophysics symposium EABS 2000
  
• 磁気誘発筋電図による脳・脊髄病変の予測  [Not invited]

  千葉 惇; 太田 善夫; 生塩 研一; 稲瀨 正彦

  第92回近畿生理学談話会  2000/04  第92回近畿生理学談話会
   

  6週～15週齢のM-SWHRSPを用いて磁気誘発筋電図による脳・脊髄病変の予測を試みた。
• Magnetically evoked EMGs in congenital hydrocephalic rats  [Not invited]

  千葉 惇; 生塩 研一; 稲瀨 正彦

  第77回日本生理学会大会  2000/03  東京  第77回日本生理学会大会
   

  SHR水頭症ラットの磁気誘発筋電図を記録した。
• 線虫全神経回路網シミュレーション(CCE計画)(]G0001[)  [Not invited]

  日本物理学会第54回年会  1999
• Simulational study on neural network of C. elegans(CCE Program)(]G0001[)  [Not invited]

  54th Annual Meeting. The Physical Society of Japan, 1999  1999
• Analysis of Neural Connectivity of C.elegans using Random walker(共著)  [Not invited]

  12th International C.elegans Meeting  1999
• アメフラシ腹部神経節ニューロンのスパイク・トレイン解析  [Not invited]

  日本生物物理学会第36回年会  1998
• Analysis of spike trains from Aplysia abdominal ganglia neurons  [Not invited]

  36th Annual Meeting. The Biophysical Society of Japan, 1998  1998
• Si/SiO₂界面へのSbパイルアップのシミュレーション  [Invited]

  第44回応用物理学関係連合講演会  1997
• Simulational Study on Sb Pile-up at Si/SiO2 Interface The 44th Spring Meeting, 1997 ; The Japan Society of Applied  [Not invited]

  Physics and Related Societies  1997

Works

• 線虫神経回路網のシミュレーション研究

  1998
• Simulational study on Neural Network of C. elegans

  1998
• アメフラシ腹部神経節ニューロンのスパイクデータ解析

  1997
• Analysis of spike data from Aplysia abdominal ganglion neurons

  1997

MISC

• Response properties of monkey striatal neurons during a duration discrimination task

  Atsushi Chiba; Ken-ichi Oshio; Masahiko Inase  JOURNAL OF PHYSIOLOGICAL SCIENCES  60-  S155  -S155  2010
• Cue response properties of monkey striatal neurons during duration discrimination task

  Atsushi Chiba; Ken-ichi Oshio; Masahiko Inase  NEUROSCIENCE RESEARCH  68-  E292  -E293  2010
• 30aPS-33 Functional roles of monkey prefrontal cortex in duration discrimination

  Oshio K; Chiba A; Inase M  Meeting abstracts of the Physical Society of Japan  64-  (1)  328  -328  2009/03
• Prefrontal neurons contribute to temporal filtering in duration discrimination

  Ken-ichi Oshio; Atsushi Chiba; Masahiko Inase  NEUROSCIENCE RESEARCH  65-  S192  -S192  2009
• Monkey striatal neurons encoded temporal information in duration discrimination task

  Atsushi Chiba; Ken-ichi Oshio; Masahiko Inase  NEUROSCIENCE RESEARCH  61-  S196  -S196  2008
• Cue-period activity of monkey prefrontal neurons during a duration-discrimination task

  Ken-ichi Oshio; Atsushi Chiba; Masahiko Inase  NEUROSCIENCE RESEARCH  58-  S116  -S116  2007
• Cue response of monkey striatal neurons during a duration discrimination task

  Atsushi Chiba; Ken-Ichi Oshio; Masahiko Inase  NEUROSCIENCE RESEARCH  58-  S231  -S231  2007
• Prophylactic effect of repetitive transcranial magnetic stimulation (rTMS) against stroke in malignant stroke-prone spontaneously hypertensive rats (M-SHRSP)

  Atsushi Chiba; Ken-ichi Oshio; Masahiko Inase  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY  145-  (3-4)  423  -423  2006/11
• The development of the objective structured skill examination in physiology education

  O Matsuo; M Inase; A Murata; A Chiba; K Oshio; K Okada; S Ueshima  FASEB JOURNAL  19-  (5)  A1392  -A1392  2005/03
• 3P240 Neural mechanisms of monkey prefrontal cortex for time perception

  Oshio K.; Chiba A.; Inase M.  Seibutsu Butsuri  44-  (1)  S249  2004/11
• 29pWB-5 A new version of the database of synptic connectivity of C. elegans

  Oshio K.; Iwasaki Y.; Morita S.; Osana Y.; Gomi S; Akiyama E.; Omata K.; Oka K.; Kawamura K.  Meeting abstracts of the Physical Society of Japan  59-  (1)  312  -312  2004/03
• Cluster Structure of Neural Circuit of C. elegans and its Functioning

  Kawamura K.; Funabashi Y.; Omata K.; Oshio K.; Morita S.; Osana Y.; Oka K.  Meeting abstracts of the Physical Society of Japan  58-  (2)  314  -314  2003/08
• 血圧上昇に伴う高血圧症ラットの下垂体血管鋳型像の変化

  千葉惇; 太田善夫; 生塩研一; 村田哲; 稲瀬正彦  日本神経科学大会プログラム・抄録集  24th-  362  2001/09
• Analysis of Excitatory and Inhibitory Pathways in Neural Network of C. elegns III

  Iwasaki Y.; Gomi S.; Oshio K.; Morita S.; Osana Y.; Oka K.  Meeting abstracts of the Physical Society of Japan  55-  (2)  257  -257  2000/09
• Structures of the C. elegans Neural Circuit

  OMATA K.; OSHIO K.; MORITA S.; OSANA Y.; OKA K.  Meeting abstracts of the Physical Society of Japan  55-  (1)  289  -289  2000/03
• A Neural Network Model for Mechanical Stimuli in C. elegans : Excitatory and Inhibitory Connections

  OSANA Y.; GOMI S.; IWASAKI Y.; AKIYAMA E.; OSHIO K.; MORITA S.; FUNABASHI Y.; OKA K.; HAGIWARA E.; KAWAMURA K.  Meeting abstracts of the Physical Society of Japan  55-  (1)  289  -289  2000/03
• Analysis of Excitatory and Inhibitory Pathways in Neural Network of C. elegans I

  Iwasaki Y.; Gomi S.; Oshio K.; Morita S.; Osana Y.; Oka K.  Meeting abstracts of the Physical Society of Japan  55-  (1)  196  -196  2000/03
• Analysis on Excitatory and Inhibitory Pathways in Network of c. elegans II

  Gomi S.; Iwasaki Y.; Oshio K.; Morita S.; Osana Y.; Oka K.  Meeting abstracts of the Physical Society of Japan  55-  (1)  196  -196  2000/03
• Similarity and Clustering Analusis of the C. elegans Neural Network

  Akiyama E.; Oshio K.; Funabashi Y.; Kawamura K.  Meeting abstracts of the Physical Society of Japan  55-  (1)  288  -288  2000/03
• Information Flow on C. elegans Neural Network and its Structure Analysis

  Funabashi Y.; Oshio K.; Akiyama E.; Kawamura K.  Meeting abstracts of the Physical Society of Japan  55-  (1)  288  -288  2000/03
• Cybanetic C. elegans Program III : Neural Circuit and Native Response of C. elegans.

  Kawamura K.; Akiyama E.; Iwasaki Y.; Oka S.; Osana Y.; Oshio K.; Omata K.; Gomi S.; Seiki A.; Funabashi Y.; Morita S.  Meeting abstracts of the Physical Society of Japan  55-  (1)  288  -288  2000/03
• 26aN-6 Analysis on synaptic connectivity of neural network of C.elegans

  OSHIO K; FUNABASHI Y; MORITA S; OSANA Y; OKA K; KAWAMURA K  Meeting abstracts of the Physical Society of Japan  54-  (2)  312  -312  1999/09
• 26aN-5 Study of Neuron Circuitry of Nematode by Computer Simulation (CCEP)II : Physical Analysis of Neuron Network of C.elegans and Its Biological Implication.

  KAWAMURA Kiyoshi; MORITA Satoru; OSHIO Kenichi; OSANA Yuko; FUNABASHI Yasuhiro; OKA Koutarou  Meeting abstracts of the Physical Society of Japan  54-  (2)  311  -311  1999/09
• 25aPS-47 A graph structure on the neural network of C.elegans

  MORITA Satoru; OSHIO Kenichi; OSANA Yuko; FUNABASHI Yasuhiro; OKA Koutarou; KAWAMURA Kiyoshi  Meeting abstracts of the Physical Society of Japan  54-  (2)  232  -232  1999/09
• 26pU-15 Analysis on the neuron network of C.elegans for the touch-induced movement

  GOMI S; IWASAKI Y; OSANA Y; OSHIO K; MORITA S; OKA K  Meeting abstracts of the Physical Society of Japan  54-  (2)  265  -265  1999/09
• High-field Domains and Chaotic Current Oscillations in Semiconductor with NDC

  TECHNICAL REPORT OF IEICE  ED96(210), 9-16-  1997
• Non-Periodic Current Oscillations in the Gunn-Effect Device with the Impact-Ionization Effect

  Journal of the Physical Society of Japan  64-  (5)  1823  -1836  1995  [Refereed]
  
• CHAOTIC CURRENT OSCILLATIONS IN THE GUNN-EFFECT DEVICE UNDER THE DC AND THE RF BIAS VOLTAGES

  K OSHIO; H YAHATA  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN  62-  (10)  3639  -3650  1993/10  [Refereed]
  

Research Grants & Projects

• Neural mechanisms of "brain timer"

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2021/04 -2024/03 

  Author : 生塩 研一

   

  私たちは１秒と２秒の時間の長さを区別できます。まるで、脳内にストップウォッチがあるかの如く。しかし、そのメカニズムはほとんど分かっていません。これまでの研究により、前頭前野、運動補足野、運動前野、大脳基底核、頭頂葉、小脳、海馬などの多くの脳領域が時間知覚において何らかの形で関与していることが分かっています。しかし、それらの各領域が時間情報処理で具体的にどのような役割を担っているのかは分かっていません。また、精神疾患によって時間感覚が歪むことも知られており、時間知覚を診断に役立てようとする試みもあります。本研究課題では、脳の前頭前野、運動前野、大脳基底核といった脳領域が時間情報処理で具体的にどのような役割を果たしているのか、視覚と聴覚の両方を時間呈示に使う時間弁別課題と、３つの時間長カテゴリを区別する時間弁別課題を実験動物に与え、単一ニューロンレベルでのニューロン活動の記録とデータ解析によって明らかにすることを目的としています。異種感覚刺激を用いた時間弁別課題では、サルに視覚刺激と聴覚刺激という異なる感覚種で時間長を呈示します。視覚刺激では時間的に変化しない色のついた図形（緑色の四角形）を、聴覚刺激ではスピーカからの2,000Hzの純音を用います。両方を同時に用いることはなく、いずれか一方を使って時間長を呈示します。サルには、２つ続けて呈示された時間長のうち、より長く呈示された時間長を選択させました。３つの時間長カテゴリを区別する時間弁別課題では、当初、時間長カテゴリを区別するだけの課題を検討していましたが、2021年度は３つの時間長カテゴリの視覚刺激を呈示したのち、ボタン押しによってそのカテゴリとは別カテゴリの時間長を生成させる課題にバージョンアップし、トレーニングとニューロン活動の計測実験を進めました。2021年度は学会発表を２件行いました。
• Functional role of the frontal lobe with "brain timer"

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2017/04 -2020/03 

  Author : OSHIO Ken-ichi

   

  We can stop a stopwatch in ten seconds with eyes closed. This suggests that our brain have timing function such as a “stopwatch”. Nonetheless, it is unclear how physical time is transformed into brain time. Temporal interval is a modality-independent physical attribute which can be perceived whether it is assigned to a visual, auditory or somatic stimulus. The frontal lobe receives inputs from multiple sensory systems and plays a role in integrating sensory information. It is therefore natural to speculate that the frontal lobe would participate in time perception and represent temporal attributes in some way. Monkeys were trained to discriminate between temporal durations associated with visual or auditory stimuli. Neuronal activity was recorded while the subjects were performing the task. We found various types neurons exhibiting phasic activity and sustained activity, and so on, which were associated with temporal processing from the prefrontal cortex and the premotor cortex.
• Neural mechanisms in duration discrimination of different sensory stimuli

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012 -2014 

  Author : OSHIO Ken-ichi

   

  Time duration is the physical quantity that does not depend on sensory modalities such as visual and auditory senses. We can discriminate between one and two seconds, although we have no specialized organ for it. The prefrontal cortex receives visual, auditory, and somatosensory inputs. Also, previous studies have shown that the prefrontal cortex contributes to duration discrimination. Therefore, the prefrontal cortex is expected to play an important role in duration discrimination. I investigated neuronal activity during monkeys conducted a duration discrimination task, in which duration was assigned visual or auditory stimulus. The results suggest that the prefrontal cortex discriminates visual and auditory duration in different ways, rather than measuring duration after extraction of temporal information from different sensory inputs.
• Functional roles of prefrontal cortex and striatum in duration discrimination

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(基盤研究(C))

  Date (from‐to) : 2009 -2011 

  Author : Kenichi OSHIO

   

  The prefrontal cortex and the basal ganglia are considered to be related with temporal estimation. However, their functions remains unclear. We recorded single-unit activity from the brain regions while monkeys were performing a duration discrimination task. We found that, in the striatum, phasic(transient) activity with various time intervals from the cue onset, which was previously found in the prefrontal cortex. Furthermore, striatal neurons showed duration-responsive activity in the following delay periods.
• A study on neural mechanisms in time perception using duration discrimination tas

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(基盤研究(C))

  Date (from‐to) : 2007 -2008 

  Author : Ken-ichi OSHIO

   

  脳の前頭前野や大脳基底核は時間計測に関与すると考えられていますが、具体的な役割は未解明です。我々は引き続いて呈示された図形の表示時間の違いを弁別する課題をサルに与えて、その課題遂行中に個々の神経細胞の活動を調べました(大脳基底核では世界初)。前頭前野が時間の長短を大まかに分ける標準時間によってフィルタリングすること、また、大脳基底核が遅延期間で時間長を発火頻度で符号化していることを見出しました。
• Temporal Information Processing in Prefrontal-Basal Ganglia Circuit

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(基盤研究(C))

  Date (from‐to) : 2006 -2007 

  Author : Masahiko INASE; Atsushi CHIBA; Ken-ichi OSHIO

   

  We have been conducting neurophysiological experiments to reveal neuronal mechanisms for temporal information processing in the prefrontal-basal ganglia circuit. Monkeys were trained to perform a duration discrimination task. In the task, two visual cues were presented successively in different duration (0.2〜1.6 sec). Each cue presentation was followed by a 1-sec delay period. The subjects were instructed to choose a longer presented cue after the second delay period. Single-unit activity was recorded from the prefrontal cortex and the striatum while the monkeys were performing the task.Prefrontal neurons showed phasic activity during the first cue period. The activity had peak time around 800ms that was close to the midpoint between long and short cue duration. This activity might have functioned for filtering cue duration to discriminate between long and short cues. In the first delay period prefrontal neurons exhibited differential activity following long and short cues. In the neurons with preference for long cues the delay activity after longer cues was uniformly high regardless of cue duration, but that after shorter cues was uniformly low. This binary change in the delay activity indicates that the prefrontal cortex could represent cue duration categorically as long or short. Striatal neurons phasically responded during the first and second delay periods. Responses during the first delay period changed depending on the first cue duration. Activity of populations of these neurons correlated with the first cue duration positively or negatively. Responses during the second delay period differed between long-short and short-long trials. These findings suggest that striatal neurons could encode cue duration with monotonically changing responses and discrimination results between the two cue durations.
• 時間情報処理における大脳皮質-基底核ループの役割

  文部科学省：科学研究費補助金(特定領域研究)

  Date (from‐to) : 2005 -2005 

  Author : 稲瀬 正彦; 千葉 惇; 生塩 研一

   

  我々は、大脳皮質前頭連合野と大脳基底核をめぐるループ回路における時間情報処理機構の解明を目指して、研究を進めている。本研究では、視覚刺激の時間弁別課題を遂行中のサルを用いて、大脳皮質前頭連合野から神経細胞活動を記録し解析した。課題では、呈示時間の異なる2種類の視覚刺激を1秒間の遅延期間(D1期間)をはさんで呈示し、続く2回目の遅延期間(D2期間)後に、その2種類の視覚刺激を同時に呈示し、呈示時間の長かった方の視覚刺激を選択させた。呈示時間は200〜1600msの間で、100ms間隔で試行毎に変化させた。刺激呈示時間の長短の順序(長-短か短-長)や視覚刺激の種類の順序も、試行毎にランダムに変えた。動物の正答率は、二つの視覚刺激の呈示時間の時間差に加えて、長短の視覚刺激の呈示順序に影響された。訓練により動物が十分に課題を遂行できるようになった後、記録実験を遂行した。2頭のサルから記録した562ニューロンについて、遅延期間(D1とD2期間)の神経細胞活動を解析した。長-短試行と短-長試行とで比較してみると、93ニューロンで遅延期活動が異なっていた。61ニューロンがD1期間に、37ニューロンがD2期間に、5ニューロンが両期間に違いを示した。D1期間のみで活動が異なっていた61ニューロンのうち、36ニューロンで長-短試行の、25ニューロンで短-長試行の活動が大きかった。長-短試行で活動が増加したニューロン群について、1番目の視覚刺激の呈示時間とD1期間の発射活動との関連を分析した。このニューロン群の活動は、D1期間の開始直後から、長い刺激後と短い刺激後とでは異なっており、刺激呈示時間が900ms付近まで増加すると、活動がステップ状に増加していた。これらの結果は、前頭連合野の神経細胞が視覚刺激の呈示時間のカテゴリ化に関わっている可能性を示す。
• Functional roles of cortico-basal gangila loops in conditional motor learning

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(基盤研究(C))

  Date (from‐to) : 2003 -2004 

  Author : Masahiko INASE; Ken-ichi OSHIO

   

  In order to examine functional roles of the prefrontal cortex in arbitrary visuomotor association, we recorded neuronal activity in the medial prefrontal cortex, area 9m, of a behaving monkey during conditional visuomotor learning. The monkey was presented a cueing visual stimulus, and following a delay period required to push, pull, or turn a manipulator according to the cue. Under the control condition three cues instructed the monkey to the three responses in a block of trials. After a few months of training the animal was familiar with these associations. Under the learning condition, two of the three familiar cues and one novel cue were presented in a block. The monkey needed to learn a new cue-response association by trial and error. Area 9m neurons responded to cue presentation. The Cue responses changed whether a cue was familiar or novel. A group of area 9m neurons responded to a novel cue, bur not to familiar ones. Other group of neurons responded to familiar cues, but not to a novel one. In a subgroup of these familiar cue-selective neurons the cue responses were enhanced under the learning condition compared to the control condition. These results suggest that cue familiarity is represented in area 9m activity and/or that the activity may be involved in action selection during the arbitrary visuomotor association learning.
• マルチレコーディングデータの解析
• 株式市場日中変動データ解析
• 半導体における非線形現象の解明とその応用
• 線虫神経回路網のシミュレーション研究
• サルの高次脳機能の解明
• 中枢神経系における多細胞同時計測データの解析
• Analysis of Multi-recording data
• Data ayalysis of stock market
• Study on Non-linear Phenomena in Semiconductors and The Applications
• Simulational Study on Neural Network of C. elegans
• Study on higher brain function of the Monkey
• Analysis of Multi-channel Recording Data in Central Nervou System

Other link

researchmap

https://researchmap.jp/read0190840