KINDAI UNIVERSITY


*A space between the first name and last name, please enter

NAKAMURA Takehiro

Profile

FacultyDepartment of Pharmacy
PositionAssistant
DegreeBachelor of Pharmaceutical Sciences
Commentator Guidehttps://www.kindai.ac.jp/meikan/2090-nakamura-takehiro.html
URL
Mail
Last Updated :2020/09/30

Research Activities

Research Interests

  • Cytotoxicity

Published Papers

  • Evaluation of phosphate ion adsorption from aqueous solution by nickel-aluminum complex hydroxides, Ogata F, Toda M, Otani M, Nakamura T, Kawasaki N, Water science and Technology, Water science and Technology, 3, 913 - 921, 2018 , Refereed
  • Simultaneous removal of dye and chemical oxygen demand from aqueous solution by combination treatment with ozone and carbonaceous material produced from waste biomass, e-Journal of Surface Science and Nanotechnology, Ogata F, Nagahashi E, Kobayashi Y, Nakamura T, Kawasaki N, e-Journal of Surface Science and Nanotechnology, e-Journal of Surface Science and Nanotechnology, 16, 229 - 235, 2018 , Refereed
  • Adsorption capability of virgin and calcined wheat bran for molybdenum present in aqueous solution and elucidating the adsorption mechanism by adsorption isotherms, kinetics, and regeneration, Fumihiko Ogata, Takehiro Nakamura, Naohito Kawasaki, Journal of Environmental Chemical Engineering, Journal of Environmental Chemical Engineering, (6), 4459 - 4466, 2018 , Refereed
  • Induction of Syndecan-4 by Organic-Inorganic Hybrid Molcules with a 1,10-phenanthroline Structure in Cultured Vascular Endothelial Cells., Hara T, Kojima T, Matsuzaki H, Nakamura T, Yoshida E, Fujiwara Y, Yamamoto C, Saito S, Kaji T, Int. J. Mol. Sci., Int. J. Mol. Sci., 18(2), 352, 2017 , Refereed
  • Adsorption of tungsten ion with a novel Fe-Mg type hydrotalcite prepared at different Mg2+/Fe3+ rations., Ogata F, Nakamura T, Ueta E, Nagahashi E, Kobayashi Y, Kawasaki N, J. Environ. Chem. Eng., J. Environ. Chem. Eng., 5, 3083 - 3090, 2017 , Refereed
  • Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells., Nakamura T, Yoshida E, Fujie T, Ogata F, Yamamoto C, Kawasaki N, Kaji T, J. Toxicol. Sci., J. Toxicol. Sci., 42, 2017 , Refereed
  • Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells., Hara T, Matsuzaki H, Nakamura T, Yoshida E, Fujiwara Y, Ohkubo T, Maruyama H, Yamamoto C, Saito S, Kaji T, Fundam. Toxicol. Sci., Fundam. Toxicol. Sci., 3, 109 - 113, 2016 , Refereed
  • Adsorption of Nitrite and Nitrate Ions from an Aqueous Solution by Fe-Mg-Type Hydrotalcites at Different Molar Ratios, Fumihiko Ogata, Noriaki Nagai, Yukine Kariya, Eri Nagahashi, Yuhei Kobayashi, Takehiro Nakamura, Naohito Kawasaki, CHEMICAL & PHARMACEUTICAL BULLETIN, CHEMICAL & PHARMACEUTICAL BULLETIN, 66(4), 458 - 465, Apr. 2018 , Refereed
    Summary:In this study, we prepared Fe-Mg-type hydrotalcites (Fe-HT3.0 and Fe-HT5.0) with different molar ratios and evaluated their adsorption capability for nitrite and nitrate ions from aqueous solution. Fe-HT is a typical hydrotalcite-like layered double hydroxide. Adsorption isotherms, as well as the effects of contact time and pH were investigated, and it was found that Fe-HT can adsorb larger amounts of nitrite and nitrate ions than Al-HT (normal-type hydrotalcite). Adsorption isotherm data were fitted to both Freundlich (correlation coefficient: 0.970-1.000) and Langmuir (correlation coefficient: 0.974-0.999) equations. Elemental analysis and binding energy of Fe-HT surface before and after adsorption indicated that the adsorption mechanism was related to the interaction between the adsorbent surface and anions. In addition, the ion exchange process is related to the adsorption mechanism. The adsorption amount increased with increasing temperature (7-25 degrees C). The experimental data fit the pseudo-second-order model better than the pseudo-first order model. The effect of pH on adsorption was not significant, which suggested that Fe-HT could be used over a wide pH range (4-12). These results indicate that Fe-HT is a good adsorbent for the removal of nitrite and nitrate ions from aqueous solution.
  • Biomass Potential of Virgin and Calcined Tapioca (Cassava Starch) for the Removal of Sr(II) and Cs(I) from Aqueous Solutions, Fumihiko Ogata, Noriaki Nagai, Erimi Ueta, Takehiro Nakamura, Naohito Kawasaki, CHEMICAL & PHARMACEUTICAL BULLETIN, CHEMICAL & PHARMACEUTICAL BULLETIN, 66(3), 295 - 302, Mar. 2018 , Refereed
    Summary:In this study, we prepared novel adsorbents containing virgin and calcined tapioca products for removing strontium (Sr(II)) and cesium (Cs(I)) from aqueous solutions. The characteristics of tapioca, along with its capacity to adsorb Sr(II) and Cs(I), were evaluated. Multiple tapioca products were prepared and tested. The adsorbent prepared by boiling the tapioca followed by calcination at 300 degrees C (BTP300) was the most effective. In addition, adsorption was affected by the adsorbent's surface properties. The Sr(II) and Cs(I) adsorbed onto BTP300 could be recovered through desorption by hydrochloric acid at different concentrations, which indicates that BTP300 can be used several times for adsorption/desorption. The results of this study suggest that BTP300, which was produced from tapioca biomass, can remove Sr(II) and Cs(I) from aqueous solutions.
  • Improvement of the Homogeneous Fenton Reaction for Degradation of Methylene Blue and Acid Orange II., Fumihiko Ogata, Takehiro Nakamura, Naohito Kawasaki, Chemical & pharmaceutical bulletin, Chemical & pharmaceutical bulletin, 66(5), 585 - 588, 2018 , Refereed
    Summary:In this study, the degradation of methylene blue (MB) and acid orange II (ORII) by the Fenton reaction was improved by using HCl and HNO3. In addition, the effects of pH, temperature, concentration of Fenton's reagent, and adjustment reagent of solution pH on the decoloration were evaluated. The results showed that the optimal pH for decoloration of MB and ORII was 2.5 and that the decoloration of MB and ORII increased with higher temperature and concentration of Fenton's reagent. Moreover, the decoloration in the Fenton-reaction process with HCl and HNO3 was greater than the decoloration with H2SO4 by approximately 4.3-5.6 and 1.7-5.6 times for MB and 3.2-3.6 and 4.6-7.2 times for ORII compared to with H2SO4. These results indicated that Fenton-reaction with HCl and HNO3 could be useful for the degradation technology of dyes compared to generally Fenton-reactions.
  • Effects of Water Addition to Prevent Deterioration of Soybean Oil by Calcium Silicate Adsorbent., Fumihiko Ogata, Mikako Obayashi, Eri Nagahashi, Takehiro Nakamura, Naohito Kawasaki, Journal of oleo science, Journal of oleo science, 67(1), 95 - 103, 2018 , Refereed
    Summary:In this study, we prepared calcium silicate at different molar ratios (Ca:Si=1:3, 1:6, and 1:9 refer to CAS-30S, CAS-60S, and CAS-90S, respectively) with water addition. The adsorbent characteristics (specific surface area, pore volume, mean pore diameter, and elemental analysis) were measured and the effect of water addition on the adsorbent surface for the prevention of deterioration was evaluated. In addition, the deterioration of soybean oil (SO) subjected to heating and aeration was investigated based on the acid value (AV) and carbonyl value (CV). The specific surface area increased in the order CAS-60S (160.51 m2/g) < CAS-30S (182.61 m2/g) < CAS-90S (204.19 m2/g). Deterioration of SO could be induced by heating and aeration with AV and CV of 1.4 mg/g and 102.9 µmol/g, respectively. The adsorbent (CAS-30S and CAS-90S) with water addition (25% and 50%) was found to decrease the AV, indicating that a small amount of water addition to adsorbent surface is important for the decreasing of AV. In addition, the correlation between the decrease in AV and the specific surface area is strongly positive (R value: 0.968). The adsorption mechanism is thought to involve interactions between the polar compounds (free fatty acids) in the SO (nonaqueous phase) and the water layer (containing calcium ions released from the adsorbent) on the adsorbent surface. In summary, the data obtained in this study provide useful information for preventing the deterioration of SO and prolonging the oil life cycle.
  • Effects of Water Addition to Prevent Deterioration of Soybean Oil by Calcium Silicate Adsorbent., Fumihiko Ogata, Mikako Obayashi, Eri Nagahashi, Takehiro Nakamura, Naohito Kawasaki, Journal of oleo science, Journal of oleo science, 67(1), 95 - 103, 2018 , Refereed
    Summary:In this study, we prepared calcium silicate at different molar ratios (Ca:Si=1:3, 1:6, and 1:9 refer to CAS-30S, CAS-60S, and CAS-90S, respectively) with water addition. The adsorbent characteristics (specific surface area, pore volume, mean pore diameter, and elemental analysis) were measured and the effect of water addition on the adsorbent surface for the prevention of deterioration was evaluated. In addition, the deterioration of soybean oil (SO) subjected to heating and aeration was investigated based on the acid value (AV) and carbonyl value (CV). The specific surface area increased in the order CAS-60S (160.51 m2/g) < CAS-30S (182.61 m2/g) < CAS-90S (204.19 m2/g). Deterioration of SO could be induced by heating and aeration with AV and CV of 1.4 mg/g and 102.9 µmol/g, respectively. The adsorbent (CAS-30S and CAS-90S) with water addition (25% and 50%) was found to decrease the AV, indicating that a small amount of water addition to adsorbent surface is important for the decreasing of AV. In addition, the correlation between the decrease in AV and the specific surface area is strongly positive (R value: 0.968). The adsorption mechanism is thought to involve interactions between the polar compounds (free fatty acids) in the SO (nonaqueous phase) and the water layer (containing calcium ions released from the adsorbent) on the adsorbent surface. In summary, the data obtained in this study provide useful information for preventing the deterioration of SO and prolonging the oil life cycle.
  • Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells, Tomoya Fujie, Yukino Segawa, Akane Uehara, Takehiro Nakamura, Tomoki Kimura, Eiko Yoshida, Chika Yamamoto, Masanobu Uchiyama, Hiroshi Naka, Toshiyuki Kaji, JOURNAL OF TOXICOLOGICAL SCIENCES, JOURNAL OF TOXICOLOGICAL SCIENCES, 41(2), 217 - 224, Apr. 2016 , Refereed
    Summary:Vascular endothelial cells are in direct contact with blood. Inorganic zinc is thought to be incapable of inducing metallothionein, which protects cells from heavy metal toxicity and oxidative stress, in vascular endothelial cells. Here, we aimed to further characterize the induction of metallothionein in vascular endothelial cells. Our results confirmed that inorganic zinc could not induce metallothionein in vascular endothelial cells. Moreover, ZnSO4 could not activate both the metal response element (MRE) transcription factor 1 (MTF-1)/MRE and Nrf2/antioxidant response element (ARE) pathways and was incapable of inducing metallothionein. In addition, bis(L-cysteinato)zincate(II), a zinc complex that activates the MTF-1/MRE pathway, increased MRE promoter activity but failed to induce metallothionein, suggesting that vascular endothelial metallothionein was not induced only by activation of the MTF-1/MRE pathway. Further analysis of a library of zinc complexes showed that zinc(II) bis(diethyldithiocarbamate) activated the MTF-1/MRE pathway but not the Nrf2/ARE pathway, increased MT-1A, MT-1E, and MT-2A mRNA levels, and induced metallothionein proteins. These data indicated that zinc complexes may be excellent tools to analyze metallothionein induction in vascular endothelial cells.