KINDAI UNIVERSITY

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Makoto Hosono

Profile

■FacultyDepartment of Medicine / Graduate School of Medical Sciences
■PositionProfessor
■Degree
■Commentator Guidehttps://www.kindai.ac.jp/meikan/2127-hosono-makoto.html
■URL
■Mail
Last Updated :2019/10/30

Education and Career

Education

  •   1979 04  - 1985 03 , Kyoto University Faculty of Medicine
  •   1989 04  - 1993 03 , Kyoto University Graduate School of Medicine, Internal Medicine System, Radiology and Nuclear Medicine

Academic & Professional Experience

  •   2005 10 ,  - 現在, Professor, Kindai University Faculty of Medicine
  •   2003 04 ,  - 2005 09 , Associate Professor, Kindai University Faculty of Medicine
  •   1995 10 ,  - 2003 04 , Lecturer, Saitama Medical University
  •   1994 10 ,  - 1995 09 , Research Fellow, French Government Research Fellowship
  •   1993 10 ,  - 1994 09 , Humboldt Foundation Research Fellow, Humboldt Foundation Research Fellowship
  •   1993 04 ,  - 1993 09 , Fellow, Kyoto University Hospital
  •   1986 04 ,  - 1989 03 , Fellow, Kitano Hospital (Osaka)
  •   1985 04 ,  - 1986 03 , Resident, Kyoto University Hospital

Research Activities

Research Areas

  • Clinical internal medicine, Radiation science

Research Interests

  • molecular imaging, tumor targeting

Published Papers

  • Manual on the proper use of yttrium-90-labeled anti-P-cadherin antibody injection for radionuclide therapy in clinical trials (Second Edition), Hosono M, Ikebuchi H, Kinuya S, Yanagida S, Nakamura Y, Yamada T, Sakaguchi K, Sugano H, Kojima K, Hatazawa J, Ann Nucl Med, in press, 2019 , Refereed
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  • Radiological protection in therapy with radiopharmaceuticals, Yonekura Y, Mattsson S, Flux G, Bolch WE, Dauer LT, Fisher DR, Lassmann M, Palm S, Hosono M, Doruff M, Divgi C, Zanzonico P, Ann ICRP, 48(1), 5 - 95, Oct. 2019 , Refereed
    DOI
  • Current status of radiation exposure to crystalline lens in ERCP (endoscopic retrograde cholangiopancreatography), Mamoru Takenaka, Makoto Hosono, Atsushi Nakai, Shunsuke Omoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Shiro Hayashi, Tsutomu Nishida, Masatoshi Kudo, Journal of Japanese Society of Gastroenterology, in press, 2019 , Refereed
  • Quantitative measurement of 219Rn radioactivity in exhaled breath from patients with bone metastasis of castration-resistant prostate cancer treated with 223RaCl2, Ooe K, Watabe T, Kamiya T, Yoshimura T, Hosono M, Shinohara A, Hatazawa J, EJNMMI Physics, 6(13), 1 - 11, Jul. 2019 , Refereed
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  • Evaluation and optimization of new PET reconstruction algorithm Bayesian penalized likelihood reconstruction in lung cancer according to lesion size, Otani T, Hosono M, Kanagaki M, Oka S, Fukumoto G, Onishi Y, Matsubara N, Kawabata K, Kimura H., American J Roentgenology, 213(2), W50 - W56, Jun. 2019 , Refereed
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  • Involvement of costal cartilage in relapsing polychondritis detected by 18F-FDG PET/CT, Fukumoto G, Hosono M, Kanagaki M, Ichinose M, Nishisaka K, Japanese Archive of Cases Conference of Clinical Nuclear Medicine, 1, 23 - 27, Jun. 2019 , Refereed
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  • Perspectives for Concepts of Individualized Radionuclide Therapy, Molecular Radiotherapy, and Theranostic Approaches, HOSONO Makoto, Nuclear Medicine and Molecular Imaging, 53(3), 167 - 171, Jun. 2019 , Refereed
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  • Rapid progression of metastatic pulmonary calcification diagnosed by 99mTc-MDP scintigraphy, Fukumoto G, Hosono M, Kanagaki M, Otani T, Ikegaki S., Japanese Archive of Cases Conference of Clinical Nuclear Medicine, 1, 17 - 22, May 2019 , Refereed
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  • Three year follow up of a phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer and bone metastases, Uemura H, Uemura H, Nagamori S, Wakumoto Y, Kimura G, Kikukawa H, Yokomizo A, Mizokami A, Kosaka T, Masumori N, Kawasaki Y, Yonese J, Nasu Y Fukasawa S, Sugiyama T, Kinuya S, Hosono M, Yamaguchi I, Akagawa T, Matsubara N, Int J Clin Oncol, 2019(5), 557 - 566, May 2019 , Refereed
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  • Projects for revision of DRLs in nuclear medicine and prospects, HOSONO Makoto, Innervision, 34(3), 32 - 33, Mar. 2019
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  • Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation, Hosono M, Ikebuchi H, Nakamura Y, Yanagida S, Kinuya S, Annals of Nuclear Medicine, 33(3), 211 - 221, Mar. 2019 , Refereed
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  • Radiation protection in therapy with radiopharmaceuticals, HOSONO Makoto, International Journal of Radiation Biology, in press, 2019 , Refereed
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  • Radiation exposure during image-guided endoscopic procedures: The next quality indicator for endoscopic retrograde cholangiopancreatography, Hayashi S, Takenaka M, Hosono M, Nishida T, World Journal of Clinical Cases, 6(16), 1087 - 1093, 2018 , Refereed
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  • Significance and application of diagnostic reference level in ICRP recommendation (Explanation of Pub.135), HOSONO Makoto, Radiation Effects Association, 10(97), 21 - 22, Oct. 2018
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  • Proposal of Criteria for Release of Patients and Use of the Normal Ward in 64Cu-ATSM Internal Radiotherapy, Yukie Yoshii, Mitsuyoshi Yoshimoto, Tatsuya Higashi, Makoto Hosono, Kakuigaku, 55(1), 77 - 87, Jul. 2018 , Refereed
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  • Impact to Z-score Mapping of Hyperacute Stroke Images by Computed Tomography in Adaptive Statistical Iterative Reconstruction, Watanabe Shota, Sakaguchi Kenta, Hosono Makoto, Ishii Kazunari, Murakami Takamichi, Ichikawa Katsuhiro, Japanese Journal of Radiological Technology, 日本放射線技術学会雑誌, 74(4), 375 - 381, Apr. 2018 , Refereed
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  • Resistance to ibritumomab, HOSONO Makoto, CHATAL Jean-François, Resistance to Targeted Anti-Cancer Therapeutics, 1 - 158, Apr. 2018 , Refereed
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  • Manual on the proper use of lutetium-177-labeled somatostatin analogue (Lu-177-DOTA-TATE) injectable in radionuclide therapy (2nd ed.), Hosono M, Ikebuchi H, Nakamura Y, Nakamura N, Yamada T, Yanagida S, Kitaoka A, Kojima K, Sugano H, Kinuya S, Inoue T, Hatazawa J, Annals of Nuclear Medicine, 32(3), 217 - 235, Apr. 2018 , Refereed
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  • Tumor Hypoxia Detected by 18F-fluoromisonidazole Positron Emission Tomography (FMISO PET) as a Prognostic Indicator of Radiotherapy (RT)., Tachibana I, Nishimura Y, Hanaoka K, Inada M, Fukuda K, Tatebe H, Ishikawa K, Nakamatsu K, Kanamori S, Hosono M, Anticancer research, 38(3), 1775 - 1781, Mar. 2018 , Refereed
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  • 孤立性内臓動脈解離のCT所見, 福井秀行, 松木充, 任誠雲, 甲斐田勇人, 柳生行伸, 小塚健倫, 細川知紗, 熊野正士, 柏木伸夫, 鶴崎正勝, 今岡いずみ, 細野眞, 石井一成, 村上卓道, Japanese Journal of Radiology, 36(Supplement), 34, Feb. 25 2018
  • 神経核内封入体病の1例, 沼本勲男, 松木充, 福井秀行, 若林雄一, 日高正二郎, 渡口真史, 藤谷哲也, 山川美帆, 兵頭朋子, 山田穣, 任誠雲, 甲斐田勇人, 柳生行伸, 柏木伸夫, 細川知紗, 小塚健倫, 鶴崎正勝, 今岡いずみ, 細野眞, 石井一成, 村上卓道, Japanese Journal of Radiology, 36(Supplement), 27, Feb. 25 2018
  • 前立腺癌における骨のマネージメント 前立腺癌骨転移に対するRa‐223の基礎, 細野眞, 細野眞, 泌尿器外科, 30(10), 1521‐1526, Oct. 15 2017
  • Basics of radium-223 for treatment of prostate cancer with bone metastasis, HOSONO Makoto, hinyoki-geka, 30(10), 1521 - 1526, Oct. 2017
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  • Safety and efficacy of radium-223 dichloride in Japanese patients with castration-resistant prostate cancer and bone metastases., Uemura H, Uemura H, Matsubara N, Kinuya S, Hosono M, Yajima Y, Doi T, International Journal of Clinical Oncology, 22(5), 954 - 963, Oct. 2017 , Refereed
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  • Features of Alpha Targeted Therapy and History of Development for Ra-223, HOSONO Makoto, Pharma Medica, 35(9), 96 - 101, Sep. 20 2017
  • Ra‐223の臨床応用について, 細野眞, 日本医学放射線学会秋季臨床大会抄録集, 53rd, S435‐S436, Aug. 18 2017
  • Phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer., Matsubara N, Nagamori S, Wakumoto Y, Uemura H, Kimura G, Yokomizo A, Kikukawa H, Mizokami A, Kosaka T, Masumori N, Kawasaki Y, Yonese J, Nasu Y, Fukasawa S, Sugiyama T, Kinuya S, Hosono M, Yamaguchi I, Tsutsui H, Uemura H, International journal of clinical oncology, Aug. 2017 , Refereed
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  • Q.Freezeが有用であった肺腺がん肝転移の1例, 藤井康司, 白髭賢也, 竹中達明, 細野眞, 核医学症例検討会症例集, 38(2), 31‐32, Aug. 2017
  • 興味深いFDG‐PET/CT所見を示した小児の後腹膜腫瘍の1例, 大西康之, 細野眞, 金柿光憲, 福本元気, 尾谷知亮, 松原菜穂子, 木村弘之, 核医学症例検討会症例集, 38(2), 41, Aug. 2017
  • A new shielding calculation method for X-ray computed tomography regarding scattered radiation., Watanabe H, Noto K, Shohji T, Ogawa Y, Fujibuchi T, Yamaguchi I, Hiraki H, Kida T, Sasanuma K, Katsunuma Y, Nakano T, Horitsugi G, Hosono M, Radiological physics and technology, 10(2), 213 - 226, Jun. 2017 , Refereed
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  • PET検診の総括から未来へ　はじめに, HOSONO Makoto, 62, 619 - 612, May 2017 , Refereed
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  • Influence of acquisition orbit on phase analysis of gated single photon emission computed tomography myocardial perfusion imaging for assessment of left ventricular mechanical dyssynchrony., Misaka T, Hosono M, Kudo T, Ito T, Syomura T, Uemura M, Okajima K, Annals of Nuclear Medicine, 31(3), 235 - 244, Apr. 2017 , Refereed
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  • CRPC治療におけるRa-223の位置付け, 赤座 英之, 酒井 英樹, 米田 俊之, 細野 眞, 和久本 芳彰, 泌尿器外科, 30(4), 409 - 416, Apr. 2017
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  • アルファ線核種の臨床利用における法令と指針, 細野眞, 日本放射線技術学会総会学術大会予稿集, 73rd, 112, Mar. 21 2017
  • 4D‐CTを用いた呼吸同期撮像法の有用性, 藤井康司, 白髭賢也, 竹中達明, 細野眞, 日本放射線技術学会総会学術大会予稿集, 73rd, 302, Mar. 21 2017
  • アイソトープ治療の現状と展望　アルファ核種の利用, 細野 眞, Japanese Journal of Radiology, 35(Suppl.), 45 - 45, Feb. 2017
  • Estimation of activity of administered 18F-fluorodeoxyglucose by measurement of the dose equivalent rate on the right temporal region of the head., Sakaguchi K, Hosono M, Imamura T, Takahara N, Hayashi M, Yakushiji Y, Ishii K, Uto T, Murakami T, EJNMMI physics, 3(1), 28, Dec. 2016 , Refereed
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  • 医療被ばくの正当化と最適化に向けて Part II 医療被ばく管理と放射線防護の現状と将来展望, 細野眞, Innervision, 31(12), 2‐4, Nov. 25 2016
  • 医療被ばくの正当化と最適化に向けて Part II II 診断参考レベル(DRL)に対する活動と課題 3.核医学検査の診断参考レベル(DRL)に対する活動と課題, 細野眞, Innervision, 31(12), 12‐14, Nov. 25 2016
  • 【医療被ばくの正当化と最適化に向けてPart II】 診断参考レベル(DRL)に対する活動と課題　核医学検査の診断参考レベル(DRL)に対する活動と課題, 細野 眞, INNERVISION, 31(12), 12 - 14, Nov. 2016
    Summary:医療放射線に関連した学会・団体が、医療被ばく研究情報ネットワーク(Japan Network for Research and Information on Medical Exposure:J-RIME)の枠組みにて協働して診断参考レベルの設定に取り組み、2015年6月7日に「診断参考レベル2015(Japan DRLs 2015)」(以下、DRLs2015)を公表した。これに含まれる6つのモダリティの1つに核医学検査がある。核医学検査の診断参考レベルは、全国のすべての核医学診療施設を対象にして調査を実施し、その集計結果に基づいて「実投与量」として設定したものである。また、小児の核医学検査における放射性薬剤の適正投与量の設定も重要な課題であった。これについては、診断参考レベルとは別の概念に基づいて検討され、「小児核医学検査適正施行のコンセンサスガイドライン」に示された。したがって、現在、成人の適正投与量についてはDRLs2015、小児の適正投与量については「小児核医学検査適正施行のコンセンサスガイドライン」に規定されている仕組みとなっており、この2つの適正投与量とその内容を十分に理解して核医学検査を実施することが要である。これらの適正投与量が公表(2013〜2015年)された後、関連した学会・団体は学術集会、機関誌、Webサイトなどを通じてその普及に努めている。(著者抄録)
  • 分子標的RIがん治療の新展開 国内のRI治療の問題点と解決のための提言, 東 達也, 池渕 秀治, 内山 眞幸, 織内 昇, 絹谷 清剛, 細野 眞, 日本癌治療学会学術集会抄録集, 54回, S18 - 2, Oct. 2016
  • Theranostics:イメージングと治療の融合, 細野眞, 核医学技術, 36, 386, Sep. 30 2016
  • Clinical outcomes of IMRT planned with or without PET/CT simulation for patients with pharyngeal cancers., Matsuura T, Nishimura Y, Nakamatsu K, Kanamori S, Ishikawa K, Tachibana I, Hosono M, Shibata T, International journal of clinical oncology, 22(1), 52 - 58, Sep. 2016 , Refereed
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  • 肺血流MAAシンチグラフィにおいて投与時の体位によりシャント率が変化した1例, 渡邊翔太, 坂口健太, 黒川敏昭, 小西達郎, 吉田修平, 又野嘉枝子, 細野眞, 核医学症例検討会症例集, 37(1), 3‐4, Aug. 2016
  • Report of a nationwide survey on actual administered radioactivities of radiopharmaceuticals for diagnostic reference levels in Japan., Watanabe H, Ishii K, Hosono M, Imabayashi E, Abe K, Inubushi M, Ohno K, Magata Y, Ono K, Kikuchi K, Wagatsuma K, Takase T, Saito K, Takahashi Y, Annals of nuclear medicine, 30(6), 435 - 444, Jul. 2016 , Refereed
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  • 診断参考レベル(DRLs)の国内導入, 細野眞, 近畿大学医学雑誌, 41(1-2), 3‐7, Jun. 23 2016
  • Myocardial changes on FDG-PET/CT after radiation therapy for esophageal cancer., 稲田正浩, 西村恭昌, 石川一樹, 花岡宏平, 坂口健太, 細野眞, 臨床放射線, 臨床放射線, 61(5), 657‐666 - 666, May 10 2016
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  • アイソトープ治療の現状と展望, 細野眞, FB News, (473), 1 - 3, May 01 2016
  • 診断参考レベルの国内導入, 細野眞, 日本診療放射線技師会誌, 63(4), 403‐405, Apr. 01 2016
  • Radioisotope Therapy of Japan: Future Perspective and Recommendations., Higashi T, Ikebuchi S, Uchiyama M, Oriuchi N, Kinuya S, Hosono M, Kaku igaku. The Japanese journal of nuclear medicine, 53(1), 27 - 43, 2016 , Refereed
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  • Performance of 11C-Pittsburgh Compound B PET Binding Potential Images in the Detection of Amyloid Deposits on Equivocal Static Images., Hosokawa C, Ishii K, Kimura Y, Hyodo T, Hosono M, Sakaguchi K, Usami K, Shimamoto K, Yamazoe Y, Murakami T, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(12), 1910 - 1915, Dec. 2015 , Refereed
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  • Feasibility of heterogeneity analysis for intratumoral hypoxia on FMISO PET/CT in radiation therapy, Hosono Makoto, Tachibana Izumi, Nishumura Yasumasa, Hanaoka Kohei, Kanamori Shuichi, Nakamatsu Kiyoshi, Ishikawa Kazuki, JOURNAL OF NUCLEAR MEDICINE, 56(3), May 01 2015 , Refereed
  • Radiation exposure of nursing staff in PET practices in correlation to performance status of patients, Hosono Makoto, Takahara Naomi, Yakushiji Yuuko, Sakaguchi Kenta, Ishii Kazunari, JOURNAL OF NUCLEAR MEDICINE, 56(3), May 01 2015 , Refereed
  • Heterogeneity of intratumoral (111)In-ibritumomab tiuxetan and (18)F-FDG distribution in association with therapeutic response in radioimmunotherapy for B-cell non-Hodgkin's lymphoma., Hanaoka K, Hosono M, Tatsumi Y, Ishii K, Im SW, Tsuchiya N, Sakaguchi K, Matsumura I, EJNMMI research, 5, 10, Mar. 14 2015 , Refereed
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  • Applicability of self-activation of an NaI scintillator for measurement of photo-neutrons around a high-energy X-ray radiotherapy machine., Wakabayashi G, Nohtomi A, Yahiro E, Fujibuchi T, Fukunaga J, Umezu Y, Nakamura Y, Nakamura K, Hosono M, Itoh T, Radiological physics and technology, 8(1), 125 - 134, Jan. 2015 , Refereed
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  • Investigation of 11C-PiB equivocal PET findings., Hosokawa C, Ishii K, Hyodo T, Sakaguchi K, Usami K, Shimamoto K, Yamazoe Y, Hosono M, Hanada K, Ueda M, Saigo K, Murakami T, Annals of nuclear medicine, 29(2), 164 - 169, Nov. 2014 , Refereed
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  • Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition., Ishii K, Hosokawa C, Hyodo T, Sakaguchi K, Usami K, Shimamoto K, Hosono M, Yamazoe Y, Murakami T, Annals of nuclear medicine, 29(1), 78 - 83, Oct. 2014 , Refereed
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  • Clinical practice guideline for dedicated breast PET., Hosono M, Saga T, Ito K, Kumita S, Sasaki M, Senda M, Hatazawa J, Watanabe H, Ito H, Kanaya S, Kimura Y, Saji H, Jinnouchi S, Fukukita H, Murakami K, Kinuya S, Yamazaki J, Uchiyama M, Uno K, Kato K, Kawano T, Kubota K, Togawa T, Honda N, Maruno H, Yoshimura M, Kawamoto M, Ozawa Y, Annals of nuclear medicine, 28(6), 597 - 602, Jul. 2014 , Refereed
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  • Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images, Hosokawa Chisa, Ishii Kazunari, Kimura Yuichi, Sakaguchi Kenta, Hosono Makoto, Murakami Takamichi, JOURNAL OF NUCLEAR MEDICINE, 55, May 2014 , Refereed
  • A newly designed radioimmunoconjugate releasing a hippurate-like radiometal chelate for enhanced target/non-target radioactivity, Arano Y, Matsushima H, Tagawa M, Inoue T, Koizumi M, Hosono M, Sakahara H, Endo K, Konishi J and Yokoyama A, Nucl Med Biol, 21, 63 - 69, 2014 , Refereed
  • A prospective clinical trial of tumor hypoxia imaging with 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) before and during radiation therapy., Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Koike R, Nishikawa T, Ishikawa K, Tamura M, Hosono M, Journal of radiation research, 54(6), 1078 - 1084, Nov. 2013 , Refereed
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  • Measurements for a Contamination Control of a ^<223>Ra Medicament, HOHARA Sin-ya, HOSONO Makoto, INAGAKI Masayo, IM Sung-Woon, MORIMOTO Hideo, HANAOKA Kohei, SAKAGUCHI Kenta, YAMANISHI Hirokuni, ITOH Tetsuo, RADIOISOTOPES, Radioisotopes, 62(9), 659 - 665, Sep. 15 2013
    Summary:In recent years, attention has been focused on radionuclide therapy with α emission nuclides. Research and clinical tests of pharmaceuticals including 223Ra, which has short half-life and a number of α & β decays with its decay family, started in Japan in this year. Despite the fact that research on pharmaceuticals including 223Ra is continuing, methods and knowledge of 223Ra radiation controls have not been researched.
    Contamination controls of radioactive pharmaceuticals in clinical sites are very important because of radiation protection, and research on 223Ra-contamination controls should be performed as soon as possible before any medical application becomes licensed.
    In this work, we performed demonstration experiments of 223Ra-contamination with commonly-used survey meters. The results of experiments show that a Geiger-Muller type survey meter(TGS-133:Hitachi Aloka Medical) is effective to find 223Ra-contamination, but an NaI(Tl) scintillation type survey meter(TCS-161:Hitachi Aloka Medical) should be used carefully due to the measurement limit in a 223Ra-contamination survey.
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  • Guidelines for clinical use of FDG PET, PET/CT 2012, 細野 眞, 佐賀 恒夫, 伊藤 健吾, 汲田 伸一郎, 佐々木 雅之, 千田 道雄, 畑澤 順, 渡邉 浩, 伊藤 浩, 金谷 信一, 木村 裕一, 佐治 英郎, 陣之内 正史, 福喜多 博義, 村上 康二, 絹谷 清剛, 山崎 純一, 内山 眞幸, 宇野 公一, 加藤 克彦, 川野 剛, 日下部 きよ子, 窪田 和雄, 戸川 貴史, 本田 憲業, 丸野 廣大, 吉村 真奈, 宍戸 文男, 井上 登美夫, 福田 寛, 中村 佳代子, Jpn J Nucl Med (Kaku Igaku), 核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine, 49(4), 391 - 401, Nov. 30 2012
  • Gamut of FDG-PET, 御前 隆, 石津 浩一, 石守 崇好, 工藤 崇, 中本 裕士, 東 達也, 細野 眞, 核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine, 核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine, 49(4), 357 - 389, Nov. 30 2012
  • Dynamic sequence respiratory gated perfusion pulmonary SPECT without external tracking device., Sakaguchi K, Hosono M, Otsuka M, Hanaoka K, Usami K, Uto T, Ishii K, Annals of nuclear medicine, Annals of nuclear medicine, 27(1), 65 - 73, Oct. 2012 , Refereed
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  • Recognition of complete response by long-term observation after treatment with 90Y-Ibritumomab tiuxetan for relapsed follicular lymphoma, Tatsumi Y, Rai S, Shimada T, Yamaguchi K, Morita Y, Kawanishi K, Miyatake J, Ashida T, Hosono M, Matsumura I, Acta Med Kinki Univ, 36(2), 87 - 89, Sep. 2012 , Refereed
  • Recognition of complete response by long-term observation after treatment with 90Y-Ibritumomab tiuxetan for relapsed follicular lymphoma, Acta　Med　Kinki Univ, 36(２), 87 - 89, Sep. 2012
  • 内用療法の環境整備, 細野眞, 核医学, 49(3), 164, Aug. 31 2012
  • 認知症における脳FDG‐PET早期撮像の可能性について, 兵頭朋子, 石井一成, 坂口健太, 花岡宏平, 宇佐美公男, 島元健次, 山添譲, 山田穣, 松木充, 細野眞, 村上卓道, 核医学, 49(3), 294, Aug. 31 2012
  • SPECT/CTを用いたバセドウ病のヨウ素131治療計画, 細野眞, 花岡宏平, 米矢吉宏, 土屋典生, 坂口健太, 高田裕史, 森元英夫, 宇佐美公男, 石井一成, 核医学症例検討会症例集, 33(1), 15-16, Aug. 2012
  • Impact of CT attenuation correction by SPECT/CT in brain perfusion images., Ishii K, Hanaoka K, Okada M, Kumano S, Komeya Y, Tsuchiya N, Hosono M, Murakami T, Annals of nuclear medicine, 26(3), 241 - 247, Apr. 2012 , Refereed
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  • 医療放射線の安全確保と有効利用に関する厚生労働省班研究の概要, 細野眞, 岡野友宏, 山口一郎, 高橋健夫, 赤羽正章, 雫石一也, 池渕秀治, 柳田幸子, 米矢吉宏, 土屋典生, 日本医学放射線学会総会抄録集, 71st, S150, Feb. 29 2012
  • 131I甲状腺内用療法におけるSPECT/CTを用いた甲状腺重量測定について, 花岡宏平, 大塚正和, 吉田修平, 井上亮, 石井一成, 村上卓道, 細野眞, 日本放射線技術学会総会学術大会予稿集, 68th, 185-186, Feb. 29 2012
  • 脳FDG集積低下を示す大きな腫瘍代謝症例の分析, 細野眞, 花岡宏平, 米矢吉宏, 土屋典生, 宇佐美公男, 高田裕史, 坂口健太, 森元英夫, IM Sung‐Woon, 石井一成, 辰巳陽一, 下野太郎, 核医学症例検討会症例集, 32(2), 41-42, Feb. 2012
  • 〈Case Reports〉Recognition of complete response by long-term observation after treatment with ^<90>Y-Ibritumomab tiuxetan for relapsed follicular lymphoma, Tatsumi Yoichi, Rai Shinya, Shimada Takahiro, Yamaguchi Terufumi, Morita Yasuhiro, Kawanishi Kazunobu, Miyatake Junichi, shida Takashi, Maeda Yasuhiro, Hosono Makoto, Matsumura Itaru, Acta Medica Kinki University, Acta Medica Kinki University, 36(2), 87 - 89, Dec. 01 2011
    Summary:[Abstract] Monoclonal antibodies have markedly changed the treatment possibilities for patients with indolent B-cell lymphoma. ^<90>Y-Ibritumomab tiuxetan (Zevalin) is the first radioimmunotherapy (RIT) agent approved for the treatment of relapsed and refractory indolent lymphoma patients. In most cases, the maximum clinical response were observed two to three months after RIT. Treatment with ^<90>Y-ibritumomab tiuxetan may have potential late effects in some cases of relapsed follicular lymphomas, and we must be careful to start the next treatment after RIT.
  • Report on the 44th Annual Meeting of Japan Health Physics Society, HOSONO Makoto, 保健物理 : hoken buturi, 保健物理 : hoken buturi, 46(4), 288 - 291, Dec. 01 2011
  • 18F‐FDG PET/CTにてsuperscanを呈した腎癌骨転移の1例, 兵頭朋子, 石井一成, 細野眞, 阪本祐一, 米矢吉宏, 柳生行伸, 土屋典生, 熊野正士, 足利竜一朗, 中村一郎, 植村天受, 村上卓道, 核医学, 48(4), 471, Nov. 30 2011
  • 核医学治療の有効性と環境整備および今後の展望, 細野眞, 核医学, 48(3), 245, Sep. 30 2011
  • 高精度放射線治療におけるPET/CTの臨床的有効性に関する検討, 大久保充, 小泉潔, 徳植公一, 西村恭昌, 細野眞, 核医学, 48(3), 238, Sep. 30 2011
  • The iliac wing sign: An indicator of the presence of bone and/or soft-tissue injury of the pelvis and hips., Kakigi T, Hosono M, Shimono T, Hiraoka T, Nishimura K, European journal of radiology, 81(9), 2348 - 2352, Sep. 2011 , Refereed
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  • Fluorodeoxyglucose uptake in the bone marrow after granulocyte colony-stimulating factor administration in patients with non-Hodgkin's lymphoma., Hanaoka K, Hosono M, Usami K, Tatsumi Y, Yamazoe Y, Komeya Y, Tsuchiya N, Ishii K, Sumita M, Nuclear medicine communications, 32(8), 678 - 683, Aug. 2011 , Refereed
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  • [Evaluation of patient dose from diagnostic X-ray using glass badges]., Usami K, Sakaguchi K, Ootsuka M, Nagamoto K, Inoue R, Fukuda K, Kano Y, Yoshida K, Hosono M, Nihon Hoshasen Gijutsu Gakkai zasshi, 日本放射線技術学会雑誌, 67(7), 785 - 792, Jul. 20 2011 , Refereed
    Summary:Radiography is used in medical practices based on the principles of justification and optimization. Patients’ exposure doses should be kept as low as still allows for image quality that does not disturb the diagnostic processes. To optimize diagnostic radiological procedures, the international commission on radiological protection (ICRP) advocated the establishment of diagnosis reference levels (DRLs) in the new basic recommendation (Publication 103) in 2007 by stating that “The DRL should be expressed as a readily measurable patient-dose-related quantity for the specified procedure.” In th...
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  • Report on the 44th Annual Meeting of Japan Health Physics Society, HOSONO Makoto, Jpn. J. Health Phys., 保健物理, 46(4), 288 - 291, 2011
  • Decreased brain FDG uptake in patients with extensive non-Hodgkin's lymphoma lesions., Hanaoka K, Hosono M, Shimono T, Usami K, Komeya Y, Tsuchiya N, Yamazoe Y, Ishii K, Tatsumi Y, Sumita M, Annals of nuclear medicine, 24(10), 707 - 711, Dec. 2010 , Refereed
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  • FDG PET/CT versus CT, MR imaging, and 67Ga scintigraphy in the posttherapy evaluation of malignant lymphoma., Okada M, Sato N, Ishii K, Matsumura K, Hosono M, Murakami T, Radiographics : a review publication of the Radiological Society of North America, Inc, 30(4), 939 - 957, Jul. 2010 , Refereed
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  • Radiation treatment planning using positron emission and computed tomography for lung and pharyngeal cancers: a multiple-threshold method for [(18)F]fluoro-2-deoxyglucose activity., Okubo M, Nishimura Y, Nakamatsu K, Okumura M, Shibata T, Kanamori S, Hanaoka K, Hosono M, International journal of radiation oncology, biology, physics, 77(2), 350 - 356, Jun. 2010 , Refereed
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  • Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult, KURIU Akihiro, SHIMONO Taro, KUWABARA Masatomo, ASHIKAGA Ryuichiro, HOSONO Makoto, MURAKAMI Takamichi, Jpn J Radiol, 28(2), 166 - 168, Feb. 2010 , Refereed
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  • Radiation treatment planning using positron emission and computed tomography (PET/CT) for lung and pharyngeal cancers: A multiple thresholds method for FDG activity., Int J Radiat Oncol Biol Phys, 77, 350 - 356, 2010
  • Worldwide trends in radiation protection in medicine, HOSONO M., Jpn. J. Radiol. Technol., 臨床放射線, 54(13), 1772 - 1778, Dec. 2009
  • Adrenal masses: the value of additional fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in differentiating between benign and malignant lesions., Okada M, Shimono T, Komeya Y, Ando R, Kagawa Y, Katsube T, Kuwabara M, Yagyu Y, Kumano S, Imaoka I, Tsuchiya N, Ashikaga R, Hosono M, Murakami T, Annals of nuclear medicine, 23(4), 349 - 354, Jun. 2009 , Refereed
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  • Ring-shaped lateral ventricular nodules: an incidental finding on brain magnetic resonance imaging., Shimono T, Hosono M, Ashikaga R, Kumano S, Imaoka I, Yagyu Y, Okada M, Kuwabara M, Murakami T, Neuroradiology, 51(3), 145 - 150, Mar. 2009 , Refereed
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  • [Research on the shielding evaluation method for medical X-ray imaging facilities]., Ohba H, Fujibuchi T, Mita S, Horikoshi A, Iwanaga T, Ikebuchi H, Hosono M, Nihon Hoshasen Gijutsu Gakkai zasshi, 日本放射線技術學會雜誌, 65(1), 57 - 63, Jan. 20 2009 , Refereed
    Summary:The purpose of this study was to verify the shielding evaluation method for medical X-ray imaging facilities in Report No. 147 of the National Council on Radiation Protection and Measurements (NCRP). We investigated the concept of radiation protection and the major revised point in Report No. 147. The goal of radiation protection in Report No. 147 was compared with that in Japan. Using the data of the Imaging Performance Assessment of CT scanners (ImPACT) 2006 and the latest pre-installation manuals of several manufactures for different computed tomography (CT) scanner models, we verified t...
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  • Integrated FDG-PET/CT compared with intravenous contrast-enhanced CT for evaluation of metastatic regional lymph nodes in patients with resectable early stage esophageal cancer., Okada M, Murakami T, Kumano S, Kuwabara M, Shimono T, Hosono M, Shiozaki H, Annals of nuclear medicine, 23(1), 73 - 80, Jan. 2009 , Refereed
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  • Static and moving phantom studies for radiation treatment planning in a positron emission tomography and computed tomography (PET/CT) system., Okubo M, Nishimura Y, Nakamatsu K, Okumura M, Shibata T, Kanamori S, Hanaoka K, Hosono M, Annals of nuclear medicine, 22(7), 579 - 586, Aug. 2008 , Refereed
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  • "Prominent ear sign" on diffusion-weighted magnetic resonance imaging in relapsing polychondritis., Kuwabara M, Shimono T, Toyomasu M, Shioyama M, Mitsui Y, Yoshinaga E, Kawada A, Hosono M, Murakami T, Kusunoki S, Radiation medicine, 26(7), 438 - 441, Aug. 2008 , Refereed
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  • Quantitative evaluation of norcholesterol scintigraphy, CT attenuation value, and chemical-shift MR imaging for characterizing adrenal adenomas., Yoh T, Hosono M, Komeya Y, Im SW, Ashikaga R, Shimono T, Tsuchiya N, Okada M, Hanada K, Yagyu Y, Nishimura Y, Murakami T, Annals of nuclear medicine, 22(6), 513 - 519, Jul. 2008 , Refereed
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  • Comparison between one-route and two-route injection for liver and aortic enhancement using MDCT., Okada M, Murakami T, Kumano S, Imaoka I, Shimono T, Ashikaga R, Hosono M, AJR. American journal of roentgenology, 190(6), 323 - 326, Jun. 2008 , Refereed
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  • Discordance of motion artifacts on magnetic resonance imaging in Creutzfeldt-Jakob disease: comparison of diffusion-weighted and conventional imaging sequences., Shimono T, Tsuboyama T, Kuwabara M, Im SW, Yagyu Y, Imaoka I, Ashikaga R, Hosono M, Murakami T, Radiation medicine, 26(3), 151 - 155, Apr. 2008 , Refereed
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  • Recent advances in unsealed radionuclide therapy, 細野 眞, 月刊新医療, 月刊新医療, 35(3), 56 - 59, Mar. 2008
  • Clinical Usefulness of [^<18>F] FDG-PET for Diagnosis of Bone and Soft Tissue Tumors : An Analysis Based on Multi-center Questionnaire Survey, KATO Katsuhiko, HOSONO Makoto, ITO Kengo, OKADA Masahiro, KOMEYA Yoshihiro, IM Sung-WOON, TSUCHIDA Norio, TORIZUKA Kanji, RADIOISOTOPES, Radioisotopes, 57(1), 13 - 23, Jan. 15 2008
    Summary:The usefulness of [18F] FDG-PET for the diagnosis of bone and soft tissue tumors was evaluated using 75 cases(20 kinds of diseases)which were collected from7institutions in Japan by sending out questionnaires. The data of the study patients, who had osteosarcoma, Ewing′s sarcoma(including primitive neuroectodermal tumor), liposarcoma, leiomyosarcoma, Hemangiosarcoma, synovial sarcoma, rhabdomyosarcoma, giant cell tumor, schwannoma, malignant fibrous histiocystoma, chondrosarcoma, alveolar soft part sarcoma, epithelioid sarcoma, endometrial stromal sarcoma, hibernoma, fibrosarcoma, multiple osteochondroma, sacral chordoma, Langerhans cell histiocytosis, and neurofibromatosis, respectively, were analyzed. From the analytical results it was concluded that the usefulness of [18F] FDG-PET is high for the diagnosis of these tumors.
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  • Clinical usefulness of <18F> FDG-PET for diagnosis of bone and soft tissue tumors: an analysis based on multi-center questionnaire survey, 加藤 克彦, 細野 眞, 伊藤 健吾, Radioisotopes, Radioisotopes, 57(1), 15 - 25, Jan. 2008
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  • [Advancement of the imaging for hepatic malignancies]., Kumano S, Okada M, Imaoka I, Shimono T, Hosono M, Murakami T, Gan to kagaku ryoho. Cancer & chemotherapy, 34, 1357 - 1360, Sep. 2007 , Refereed
  • Contrast enhanced MDCT, 22(5), 106 - 109, 2007
  • Regional cerebral blood flow in the assessment of major depression and Alzheimer's disease in the early elderly., Hanada K, Hosono M, Kudo T, Hitomi Y, Yagyu Y, Kirime E, Komeya Y, Tsujii N, Hitomi K, Nishimura Y, Nuclear medicine communications, 27(6), 535 - 541, Jun. 2006 , Refereed
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  • Radiotherapy and ND-YAG laser for locally advanced non-small cell lung cancer with malignant airwary stenosis and dyspnea, NISHIMURA Keiichiro, TAKAHASHI Takeo, OSADA Hisato, MURATA Osamu, HONDO Mikito, HOSONO Makoto, HONDA Norinari, The Journal of JASTRO, The Journal of JASTRO = 日本放射線腫瘍学会誌, 17(2), 97 - 101, Jun. 25 2005
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  • Aggressive multiple lung metastases from intracranial atypical meningioma, Jpn J Tomogrraphy, 32(1), 24 - 27, Jan. 2005
  • RADIOTHERAPY AND ND-YAG LASER FOR LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER WITH MALIGNANT AIRWAY STENOSIS AND DYSPNEA, NISHIMURA Keiichiro, TAKAHASHI Takeo, OSADA Hisato, MURATA Osamu, HONDO Mikito, HOSONO Makoto, HONDA Norinari, The Journal of JASTRO, 日本放射線腫瘍学会誌, 17(2), 97 - 101, 2005
    Summary:Locally advanced non-small cell lung cancer is often inoperable. It is difficult to choose the optimal therapy for locally advanced lung carcinoma with malignant airway obstruction. We applied Neodymiumyttrium-aluminum garnet (Nd-YAG) laser therapy combined with external beam radiotherapy. Seven patients were treated with Nd-YAG laser and 60 Gy and more of conventional radiotherapy. All patients had malignant airway obstructions and severe dyspnea at the beginning of Nd-YAG laser therapy. These patients received good to excellent palliation and were able to have normal daily lifes after the treatments. The Nd-YAG laser combined with external radiotherapy may be one of the most useful treatment for locally advanced lung cancer with malignant airway stenosis to improve quality of life.
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  • A new bifunctional chelating agent conjugated with monoclonal antibody and labelled with technetium-99m for targeted scintigraphy:6-(4-isothiocyanatobenzyl)-5, 7-dioxo -1, 11- (carboxymethyl)-1, 4, 8, 11 - tetraazacyclotridecane, MISHRA Ak, PANWAR P, HOSONO M, CHUTTANI K, MISHRA P, SHARMA Rk, CHATAL Jf, J Drug Targeting, 12(9-10), 559 - 567, Oct. 2004 , Refereed
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  • Extraosseous accumulation of 99mTc-MDP in lymph node metastases of small cell carcinoma of the esophagus, Ann Nucl Med, 18, 157 - 160, Oct. 2004
  • Extraosseous accumulation of 99mTc-MDP in lymph node metastases of small cell carcinoma of the esophagus., Takahashi T, Machida K, Honda N, Hosono M, Oku S, Osada H, Murata O, Nishimura K, Ohno H, Annals of nuclear medicine, 18, 157 - 160, Apr. 2004 , Refereed
  • [Drawing up the guidelines for ventilation, draining and disposal of radioactive medical waste]., Koizumi M, Endo K, Yokoyama K, Narita Y, Kinoshita F, Hosono M, Kusakabe K, Kosaka N, Mori Y, Kosuda S, Kaku igaku. The Japanese journal of nuclear medicine, 41, 48 - 50, Feb. 2004 , Refereed
  • Three-dimensional stereotactic surface projection of brain perfusion SPECT improves diagnosis of Alzheimer's disease., Honda N, Machida K, Matsumoto T, Matsuda H, Imabayashi E, Hashimoto J, Hosono M, Inoue Y, Koizum K, Kosuda S, Momose T, Mori Y, Oshima M, Annals of nuclear medicine, 17, 641 - 648, Dec. 2003 , Refereed
  • Optimal Injection Protocol In Hepatic Dynamic CT Using MDCT, 23(9), 1017 - 1025, Sep. 2003
  • Distribution of intrasplenically injected colon cancer cells following pneumoperitoneum in mice, Surg Endosc, 17(8), 1278 - 1282, Aug. 2003
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  • Visualization of fatal hepatic necrosis on bone scan., Hosono M, Machida K, Honda N, Takahashi T, Ohtawa N, Clinical nuclear medicine, 28, 398 - 399, May 2003 , Refereed
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  • Spontaneous regression of chest wall malignant lymphoma. Presentation on Ga-67 imaging., Machida K, Inoue Y, Honda N, Hosono M, Takahashi T, Kashimada A, Clinical nuclear medicine, 28, 405 - 407, May 2003 , Refereed
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  • Adult embryonal rhabdomyosarcoma in axilla., Takahashi T, Machida K, Honda N, Hosono M, Kashimada A, Murata O, Osada H, Nishimura K, Radiation medicine, 21, 135 - 137, May 2003 , Refereed
  • Spontaneous regression of chest wall malignant lymphoma presentation on Ga-67 imaging, Clin Nucl Med, 28(5), 405 - 407, May 2003
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  • Visualization of fatal hepatic necrosis on bone scan, HOSONO M, MACHIDA K, HONDA N, TAKAHASHI T, OHTAWA N, Clinical Nuclear Medicine, 28(5), 398 - 399, May 2003
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  • Adult embryonal rhabdomyosarcoma in axilla, Radiation Medicine, 21(3), 135 - 137, Mar. 2003
  • Gallium-67 demonstration of extensive soft-tissue involvement of multiple myeloma., Hosono M, Machida K, Inoue Y, Honda N, Takahashi T, Kashimada A, Ohtawa N, Ohno H, Yamano T, Annals of nuclear medicine, 17(1), 69 - 72, Feb. 2003 , Refereed
  • Effective radiotherapy and an abscopal effect for bone metastases of an unknown origin, Jpn J Tomogrraphy, 30, 96 - 99, Feb. 2003
  • Intense Ga-67 accumulation in pure primary mediastinal seminomas., Hosono M, Machida K, Honda N, Takahashi T, Kashimada A, Murata O, Osada H, Ohtawa N, Itoyama S, Clinical nuclear medicine, 28, 25 - 28, Jan. 2003 , Refereed
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  • Gallium-67 demonstration of extensive soft-tissue involvement of multiple myeloma, Ann Nucl Med, 17(1), 69 - 72, Jan. 2003
  • Intense gallium-67 accumulation in primary mediastinal pure seminomas, HOSONO M, MACHIDA K, HONDA N, TAKAHASHI T, KASHIMADA A, MURATA O, OSADA H, OHTAWA N, ITOYAMA S, Clinical Nuclear Medicine, 28(1), 25 - 28, Jan. 2003
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  • EVALUATION OF QOL IN CANCER PATIENTS TREATED WITH RADIATION THERAPY, TAKAHASHI Takeo, MACHIDA Kikuo, HONDA Norinari, HOSONO Makoto, MURATA Osamu, OSADA Hisato, OMICHI Masahide, The Journal of JASTRO, The Journal of JASTRO = 日本放射線腫瘍学会誌, 14(4), 233 - 238, Dec. 25 2002
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  • Quantitative lung perfusion scintigraphy and detection of intrapulmonary shunt in liver cirrhosis., Hosono M, Machida K, Honda N, Takahashi T, Kashimada A, Osada H, Murata O, Ohtawa N, Nishimura K, Annals of nuclear medicine, 16, 577 - 581, Dec. 2002 , Refereed
  • Quantitative lung perfusion scintigraphy and detection of intrapulmonary shunt in liver cirrhosis, Ann Nucl Med, 16(8), 577 - 581, Dec. 2002
  • Interobserver variation in diagnosis of dementia by brain perfusion SPECT., Honda N, Machida K, Hosono M, Matsumoto T, Matsuda H, Oshima M, Koizumi K, Kosuda S, Momose T, Mori Y, Hashimoto J, Shimizu Y, Radiation medicine, 20, 281 - 289, Nov. 2002 , Refereed
  • Scintigraphic findings of MALT lymphoma of the thyroid., Honda N, Machida K, Inoue Y, Hosono M, Takahashi T, Kashimada A, Osada H, Murata O, Ohmichi M, Watanabe W, Okada T, Itoyama S, Annals of nuclear medicine, 16, 289 - 292, Jun. 2002 , Refereed
  • Current topics of nuclear medicine in lung cancer, 本田 憲業, 町田 喜久雄, 細野 眞, 月刊新医療, 月刊新医療, 29(5), 112 - 115, May 2002
  • Interobserver variation in diagnosis of dementia by brain perfusion SPECT, Radiation Medicine, 20, 281 - 289, May 2002
  • Increased insufflation pressure enhances the development of liver metastasis in a mouse laparoscopy model, Surg Endosc, 16, 331 - 335, Mar. 2002
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  • Measurement of decreased cerebellar blood flow of Machado-Joseph Disease by brain perfusion SPECT, Jpn J Tomography, 28, 94 - 98, Mar. 2002
  • Increased uptake of Tc-99m MDP in pulmonary osseous chondrosarcoma in a patient with Carney’s syndrome, Jpn J Tomography, 29, 29 - 32, Jan. 2002
  • Noninvasive quantitative monitoring of cerebral blood flow in aneurysmal subarachnoid hemorrhage with 99mTc-ECD, Nucl Med Comm, 23, 5 - 11, Jan. 2002
  • Evaluation of QOL in cancer patients treated with radiation therapy., TAKAHASHI Takeo, MACHIDA Kikuo, HONDA Norinari, HOSONO Makoto, MURATA Osamu, OSADA Hisato, OMICHI Masahide, J Jpn Soc Ther Radiol Oncol, The Journal of JASTRO, 14(4), 233 - 238, 2002
    Summary:Introduction: Evaluation of QOL in cancer patients is an important theme. However, we do not have an established method to assess QOL in cancer patients during radiotherapy in Japan. We evaluated both the changes of QOL and the factors affecting QOL in radiotherapy patients.
    Materials and Methods: Three hundred and fifty-five cancer patients, who filled in a questionnaire at the beginning, middle, and end of radiotherapy between 1998 and 2001, were studied. Weused"The QOL Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL-ACD)" devisedby Kurihara et al, the Ministry of Health and Welfare. The QOL Questionnaire had five categories: physical activity, physical condition, mental state, social interaction, and face scale. The total score, sum of the score of five categories, were established synthetically (maximum score is 110).
    Results: The mean of total QOL scores were 75.8, 77.6, and 78.2 at the beginning, middle, and end of radiotherapy respectively. Patients with symptoms related to cancer had apparent improvement of QOL score. Patients receiving chemotherapy had a decreased QOL score at the end of radiotherapy. The score of physical condition was reduced improvement.
    Conclusions: It was suggested that radiotherapy could be performed without losing QOL of cancer patients, including older patients. However, patients receiving chemotherapy and those with head and neck cancer may lose their QOL, therfore, we should treat such patients carefully.
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  • Oligodendroglioma with cystic component in infant, Computerized Medical Imaging and Graphics, 25, 361 - 365, Oct. 2001
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  • Rhenium-188-labeled anti-neural cell adhesion molecule antibodies with 2-iminothiolane modification for targeting small-cell lung cancer, Hosono MN, Hosono M, Mishra AK Faivre-Chauvet A Gautherot E Barbet J Knapp FF Chatal JF, Ann Nucl Med, 14, 173 - 179, Jun. 2000 , Refereed
  • Clinical Application of 133-Xe Ventilation Scintigraphy, HONDA Norinari, MACHIDA Kikuo, HOSONO Makoto, 日本醫學放射線學會雜誌, 日本醫學放射線學會雜誌, 60(5), 237 - 242, Apr. 25 2000
  • Clinical Application of 133-Xe Ventilation Scintigraphy, Honda Norinari, Machida Kikuo, Hosono Makoto, 日本医学放射線学会雑誌, 日本医学放射線学会雑誌, 60(5), 237 - 242, Apr. 25 2000
  • Two-step targeting and dosimetry for small-cell lung cancer xenograft with anti-NCAM/anti-histamine bispecific antibody and radioiodinated bivalent hapten, Hosono M, Hosono MN, Kraeber-Bod?r? F Devys A Thedrez P Faivre-Chauvet A Gautherot E Barbet J Chatal JF, J Nucl Med, 40, 1216 - 1221, Oct. 1999 , Refereed
  • Cardivascular effects of colforsin daropate hydrochloride, a novel drug for the treatment of acute heart failure, HOSONO Makoto, Folia Pharmacologica Japonica, 日本薬理学雑誌, 114(2), 83 - 88, Aug. 01 1999
    Summary:Colforsin daropate hydrochloride (COL) is a water-soluble forskolin derivative for the treatment of acute heart failure. COL, like forskolin, stimulated adenylate cyclase (AC) directly and produced pharmacologic activities accompanied by the increase in cellular cAMP. COL was different from forskolin in water-solubility, duration of action, BBB permeability, oral activity and AC-subtype selectivity. COL was a inodilator with positive inotropic and vasodilator effects and was effective on a β-receptor desensitized-heart model in which the effects of β-agonists and PDE inhibitors were attenuated. COL improved cardiac function in some heart failure models. In the clinical studies, COL improved hemodynamics, subjective and objective symptoms of heart failure patients, and was also effective in the catecholamine-resistaiit heart failure patients. COL is a first clinically available adenylate cyclase activator. Further information from the post-marketing-surveillance will provide information that will enable more adequate usage of this drug.
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  • Nuclear Oncology with Monoclonal Antibodies and Peptides, HOSONO Makoto, 核医学, 35(8), 681 - 687, Oct. 20 1998
  • Nuclear Oncology with Monoclonal Antibodies and Peptides, HOSONO Makoto, 核医学, 核医学, 35(8), 681 - 687, Oct. 20 1998
  • Nuclear Medicine in Europe, HOSONO Makoto, Radioisotopes, Radioisotopes, 47(6), 531 - 532, Jun. 1998
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  • Localization of colorectal carcinoma by rhenium-188-labeled B72.3 antibody in xenografted mice, Hosono MN, Hosono M, Zamora PO, Guhlke S, Haberberger T, Bender H, Knapp FFR Jr and Biersack HJ, Ann Nucl Med, 12(2), 83 - 88, Feb. 1998 , Refereed
  • Nuclear medicine in Europe. Mainl on France., 細野 眞, RADIOISOTOPES, ＲＡＤＩＯＩＳＯＴＯＰＥＳ, 47(6), 531 - 532, 1998
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  • Biodistribution and dosimetric study in medullary thyroid cancer xenograft using bispecific antibody and iodine-125-labeled bivalent hapten, Hosono M, Hosono MN, Kraeber-Bodéré F, Devys A, Thedrez P, Fiche M, Gautherot E, Barbet J and Chatal JF, J Nucl Med, 39(9), 1608 - 1613, 1998 , Refereed
  • Localization of small-cell lung cancer xenografts with I-125-, In-111-, and Re-188-somatostatin analogs, Hosono M, Hosono MN, Haberberger T, Zamora PO, Bender H, Guhlke S, Knapp FFR Jr and Biersack HJ, Cancer Science, 87, 995 - 1000, 1996 , Refereed
  • Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using anti-CA125 monoclonal antibody, Sakahara H, Hosono M, Kobayashi H, Yao Z, Saga T, Yano S, Endo K, Mori T and Konishi J, Cancer Science, 87, 655 - 661, 1996 , Refereed
  • Immnoscintigraphy of colorectal cancer using 111In-labeled monoclonal antibody to mucin, Cancer Immunol Immunother, Cancer Immunol Immunother, 41, 1157 - 1161, 1995 , Refereed
  • Diagnostic value of Tc-99m(V) DMSA for chondrogenic tumors with positive Tc-99m HMDP uptake on bone scintigraphy, Kobayashi H, Kotoura Y, Hosono Mariko, Sakahara H, Hosono M, Yao Z, Ysuboyama T, Yamamuro T, Endo K and Konishi J, Clinical Nuclear Medicine, 20, 361 - 364, 1995 , Refereed
  • Radioimmunodetection of human leukemia with anti-interleukin-2 receptor antibody in severe combined immunodeficiency mice, Hosono M, Takaori-Kondo A, Yao Z, Kobayashi H, Hosono MN, Sakahara H, Imada K, Okuma M, Uchiyama T and Konishi J, Nuclear Medicine and Biology , 22, 869 - 874, 1995 , Refereed
    DOI
  • Detection of homing, proliferation, and infiltration sites of adult T cell leukemia cells in severe combined immunodeficiency mice using radiometric techniques, Takaori-Kondo A, Hosono M, Imada K, Yao Z, Sakahara H, Yamabe H, Konishi J, Okuma M and Uchiyama K, Cancer Science, 86, 322 - 328, 1995 , Refereed
  • Comparison of the chase effects of avidin, streptavidin, neutravidin, and avidin-ferritin on a radiolabeled biotinylated anti-tumor monoclonal antibody, Kobayashi H, Sakahara H, Endo K, Hosono M, Yao Z, Toyama S and Konishi J, Cancer Science, 86, 310 - 314, 1995 , Refereed
  • Kinetics of platelets in dogs with thrombocytopenia induced by antiglycoprotein IIb/IIIa receptor monoclonal antibody, Hosono M, Sone N, Endo K, Saga T, Kobayashi H, Hosono MN, Sakahara H, Yasunaga K and Konishi J, Nuclear Medicine and Biology, 22, 71 - 76, 1995 , Refereed
    DOI
  • Case report: Uptake of pentavalent technetium-99m dimercaptosuccunic acid by pigmented villonodular synovitis: comparison with computed tomography, magnetic resonance imaging and gallium-67 scintigraphy, Kobayashi H, Kotoura Y, Hosono M, Sakahara H, Yamamuro T, Endo K and Konishi J, Br J Radiology, 67, 1030 - 1032, 1994 , Refereed
  • Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as "chase" without decreased accumulation in the target tumor, Kobayashi H, Sakahara H, Hosono M, Yao Z, Toyama S, Endo K and Konishi J, J Nucl Med, 35, 1677 - 1684, 1994 , Refereed
  • Initial studies on Tc-99m- and Re-188-somatostatin analogues: stannous-mediated direct-labeling and biodistribution in normal mice, Haberberger T, Zamora P, Hosono M, Hosono MN, Bender H, Guhlke S, Knapp FFR and Biersask HJ, Technetium and Rhenium chemistry and nuclear medicine, 1994 , Refereed
  • Intraosseous hemangiomatosis: technetium-99m-(V)-dimercaptosuccinic acid and technetium-99m-hydroxymethylene diphosphonate imaging, Kobayashi H, Shigeno C, Sakahara H, Hosono Mariko, Hosono M, Yao Z, Endo K and Konishi J, J Nucl Med, 35, 1482 - 1484, 1994 , Refereed
  • Scintigraphic detection of neural-cell-derived small-cell lung cancer using glioma-specific antibody, Kobayashi H, Sakahara H, Hosono M, Shirato M, Kondo S, Miyatake S, Kikuchi H, Namba Y, Endo K and Konishi J, J Cancer Res Clin Oncol, 120, 259 - 262, 1994 , Refereed
  • Schwannoma of the extremities: comparison of MRI and pentavalent technetium-99m-dimercaptosuccinic acid and gallium-67-citrate scintigraphy, Kobayashi H, Kotoura Y, Sakahara H, Hosono Mariko, Hosono M, Tsaboyama T, Yamamuro T, Endo K and Konishi J, J Nucl Med, 35, 1174 - 1178, 1994 , Refereed
  • Pentavalent technetium-99m dimercaptosuccinic acid SPECT of metastatic renal cell carcinoma in the scalp and in the brain, Kobayashi H, Sakahara H, Hosono M, Shirato M and Konishi J, Clin Nucl Med, 19, 136 - 137, 1994 , Refereed
  • Soft-tissue tumors: diagnosis with Tc-99m(V) dimiercaptosuccinic acid scintigraphy, Kobayashi H, Sakahara H, Hosono M, Shirato M, Endo K, Kotoura Y, Yamamuro T and Konishi J, Radiology, 190, 277 - 280, 1994 , Refereed
  • Treatment of small cell lung cancer xenografts with iodine-131-anti-neural cell adhesion molecule monoclonal antibody and evaluation of absorbed dose in tissue, Hosono M, Endo K, Hosono MN, Kobayashi H, Shirato M, Sakahara H, Ueda R and Konishi J, J Nucl Med, 35, 296 - 300, 1994 , Refereed
  • Effect of hyperthermia on tumor uptake of radiolabeled anti-neural cell adhesion molecule antibody in small cell lung cancer xenografts, Hosono MN, Hosono M, Endo K, Ueda R and Onoyama Y, J Nucl Med, 35, 504 - 509, 1994 , Refereed
  • Dissociation in serum CA125 concentrations measured by different monoclonal antibodies, Sakahara H, Kousaka T, Hattori N, Tomida K, Yao Z, Hosono M, Kobayashi H, Shirato M, Endo K and Konishi J, Gynecologic Oncology, 52, 301 - 305, 1994 , Refereed
  • Scintigraphic detection of xenographted tumors producing human basic fibroblastic growth factor, Kobayashi H, Sakahara H, Hosono M, Shirato M, Konishi J, Takahashi JA, Oda A, Kikuchi H, Endo K and Kozai Y, Cancer Immunology Immunotherapy, 37, 281 - 285, 1993 , Refereed
  • Scintigraphic evaluation of tenosynovial giant cell tumor using technetium-99m(V)-dimercaptosuccinic acid, Kobayashi H, Sakahara H, Hosono M, Shirato M, Konishi J, Kotoura Y, Yamamuro T and Endo K, J Nucl Med, 34, 1745 - 1747, 1993 , Refereed
  • Changes in CA125 release and surface expression caused by drugs in uterine cervix adenocarcinoma cells, Nakai T, Sakahara H, Endo K, Shirato M, Kobayashi H, Hosono M, Saga T, Sakamoto M and Konishi J, Annals of Nuclear Medicine, 7, 133 - 139, 1993 , Refereed
  • Similarity and co-expression of tumour-associated antigens recognized by different monoclonal antibodies, Sakahara H, Saga T, Endo K, Kousaka T, Hosono M, Kobayashi H, Shirato M and Konishi J, Br J Cancer, 68, 920 - 925, 1993 , Refereed
  • In vivo instability of reduction-mediated 99mTc-labeled monoclonal antibody, Sakahara H, Saga T, Endo T, Hattori N, Hosono M, Kobayashi H, Shirato M, Yamamuro T, Toyama S, Arano Y, Yokoyama A and Konishi J, Nucl Med Biol, 20, 617 - 623, 1993 , Refereed
  • Technetium-99m(V) dimercaptosuccinic acid uptake in intra-abdominal massive deposit of amyloid protein, Kobayashi H, Sakahara H, Itoh T, Kudoh T, Takagi T, Shibuya K, Nomura S, Hosono M, Endo K and Konishi J, J Nucl Med, 34, 815 - 817, 1993 , Refereed
  • A human/mouse chimeric monoclonal antibody against CA125 for radioimmunoimaging of ovarian cancer, Kobayashi H, Sakahara H, Saga T, Hosono M, Shirato M, Kanda H, Ishibashi K, Watanabe T, Endo K, Ishiwata I and Konishi J, Cancer Immunol Immunother, 37, 143 - 149, 1993 , Refereed
  • Construction of immunoradiometric assay for circulating c-erbB-2 protooncogene product in advanced breast cancer patients, Hosono M, Saga T, Sakahara H, Kobayashi H, Shirato M, Endo K, Yamamoto T, Akiyama T, Toyoshima K and Konishi J, Cancer Science, 84, 147 - 152, 1993 , Refereed
  • Different antigenic nature in apparently healthy females with high serum CA125 levels -compared with typical ovarian cancer patients-, Hosono MN, Endo K, Sakahara H, Watanabe Y, Saga T, Nakai T, Hosono M, Nakajima T, Onoyama Y and Konishi J, Cancer, 70(12), 2851 - 2856, 1992 , Refereed
  • Human/mouse chimeric antibodies show low reactivity with human anti-murine antibodies(HAMA), Hosono M, Endo K, Sakahara H, Watanabe Y, Saga T, Nakai T, Kawai C, Matsumori A, Yamada T, Watanabe T and Konishi J, Br J Cancer, 65, 197 - 200, 1992 , Refereed
  • Drug effects on CA125 antigen expression and antibody binding to cancer cells, Nakai T, Endo K, Hosono M, Saga T, Watanabe Y, Sakahara H, Imai K, Yachi A, Kiyozuka Y, Ishiwata I and Konishi J, Int J Cancer, 48, 463 - 467, 1991 , Refereed
    DOI
  • Scintigraphic detection of overexpressed c-erbB-2 protooncogene products by a class-switched murine anti-c-erbB-2 protein monoclonal antibody, Saga T, Endo K, Akiyama T, Sakahara H, Koizumi M, Watanabe Y, Nakai T, Hosono M, Yamamoto T, Toyoshima K and Konishi J, Cancer Res, 51, 990 - 994, 1991 , Refereed
  • An antibody-tumor model for the targeting of CA125-producing gynecologic malignancies, Saga T, Ishiwata I, Endo K, Sakahara H, Koizumi M, Watanabe Y, Nakai T, Hosono M, Ishikawa H, Sawada M and Konishi J, Cancer Science, 81, 1141 - 1148, 1990 , Refereed
  • Influence of cocktails of labeled monoclonal antibodies on the localization of antibodies in human tumor xenografts, Watanabe Y, Endo K, Saga T, Koizumi M, Sakahara H, Nakai T, Hosono M, Yao Z, Kuroki M, Matsuoka Y and Konoshi J, Cancer Science, 81, 266 - 271, 1990 , Refereed
  • Bilio-enteric anastomosis as a risk factor for postembolic hepatic abscesses, Okajima K, Kohno S, Tamaki M, Hosono M, Kawamoto M, Nishiyama Y, Sugano M and Miyaoka T, Cardiovasc Intervent Radiol, 12, 128 - 130, 1989 , Refereed
  • CT manifestations of a ruptured hepatic tumor after transcatheter arterial embolization, Nagata Y, Kohno S, Saga T, Okajima K, Hosono M, Tamaki M, Kanata T, Takabayashi A and Matsuda S, CT manifestations of a ruptured hepatic tumor after transcatheter arterial embolization, 13, 419 - 422, 1989 , Refereed
  • Transcatheter Arterial Embolization for Osseous Metastasis of Hepatocellular Carcinoma, Nagata Yasushi, Nakano Yoshihisa, Takahashi Masaji, Abe Mitsuyuki, Saga Tsuneo, Okajima Kaoru, Hosono Makoto, Kohno Shigene, 日本医学放射線学会雑誌, 日本医学放射線学会雑誌, 48(4), 417 - 422, Apr. 25 1988

Books etc

  • Health and labor science research grant aid research fiscal year 2016-2018 Research on medical radiation protection corresponding to new treatment method general research report, HOSONO Makoto, YAMAGUCHI Ichiro, TAKAHASHI Takeo, AKAHANE Masaaki, Joint Work,   2019 03
  • Health and Labor Science Research Grants Subsidy Research 2018 "Research on medical radiation protection corresponding to new treatment methods general research report, HOSONO Makoto, YAMAGUCHI Ichiro, TAKAHASHI Takeo, AKAHANE Masaaki, Joint Work,   2019 03
  • Heterogeneity of intratumoral antibody distribution, HANAOKA Kohei, HOSONO Makoto, Joint Work, Springer International Publishing,   2018 04 , 978-3-319-78237-9
  • Features of ibritumomab as radionuclide therapy. Resistance to ibritumomab in lymphoma, HOSONO Makoto, Joint Work, Resistance to ibritumomab in lymphoma, Springer International Publishing,   2018 04 , 978-3-319-78238-6
  • Gamut of FDG-PET, HOSONO Makoto, Joint Work, JSNM,   2012 10
  • Safety and Efficient Use of Radiation in Medicine, HOSONO Makoto, Joint Work, Comprehensive Report,   2012 03
  • Comparison of functions of CT, MRI, and PET, Joint Work,   2005 10

Conference Activities & Talks

  • Present status and revision works of DRLs, HOSONO Makoto, 55th Autumn Meeting of Japan Radiological Society,   2019 10 20 , 招待有り, TOYAMA Hiroshi
  • Recent updates on radionuclide therapy -focusing on Ra-223-, HOSONO Makoto, 19th Kinki Radiology Forum ,   2019 10 05 , 招待有り
  • Basics of radiation therapy, HOSONO Makoto, 84th Annual Meeting of Eastern Section of Japanese Urological Association,   2019 10 03 , 招待有り, ASANO Tomohiko
  • Outline of research on radiation protection in medicine for novel therapeutic procedures by grant of MHLW for fiscal years 2016-2018, HOSONO Makoto, TAKAHASHI Takeo, YAMAGUCH Ichiro, AKAHANE Masaaki, IKEBUCHI Hideharu, YANAGIDA Sachiko, NAKAMURA Yoshihide, 36th Meeting of Japanese Society of Hyperthermia,   2019 09 07 , TAKAHASHI Takeo
  • Trends in safe utilization of medical radiation, HOSONO Makoto, 37th Meeting of Southern Osaka Imaging Study Consortium,   2019 08 28 , 招待有り
  • Optimization of respiratory gated 18F-FDG PET/CT scan protocol for cardiac sarcoidosis, Hanaoka K, Watanabe S, Kaida H, Hosono M, Ishii K, Annual Meeting of Society of Nuclear Medicine Molecular Imaging,   2019 06 22 , Society of Nuclear Medicine Molecular Imaging
  • Comparison among 18F-FDG uptake parameters for assessing the prognosis of esophageal squamous cell carcinoma, Kaida H, Shiraishi O, Iwama M, Kimura Y, Kitajima K, Hosono M, Yasuda T, Ishii K, Annual Meeting of Society of Nuclear Medicine Molecular Imaging,   2019 06 22 , Society of Nuclear Medicine Molecular Imaging
  • Evaluation of respiratory motion-corrected PET/CT in oncological patients, Otani T, Hosono M, Nakamoto Y, Kidera K, Kitaguchi K, Watanabe M, Miyake K, Annual Meeting of Society of Nuclear Medicine Molecular Imaging,   2019 06 22 , Society of Nuclear Medicine Molecular Imaging
  • Examination of actual radiation exposure dose of the patients who performed EUS-guided dranage (EUS-BD/EUS-PD/EUS-CD), Takenaka M, Hayashi S, Nishida T, Hosono M, Yoshikawa T, Ishikawa Rei, Okamoto A, Yamazaki T, Nakai A, Omoto S, Minaga K, Kamata K, Yamao K, Kudo M, DDW 2019,   2019 05 18 , DDW 2019
  • Radiation protection standards in novel radionuclide therapy, HOSONO Makoto, The 13th Asia Oceania Congress of Nuclear Medicine and Biology,   2019 05 10 , 招待有り, Asia Oceania Federation of Nuclear Medicine and Biology
  • Guidelines in radionuclide therapy, HOSONO Makoto, 19th Spring Meeting of Japanese Society of Nuclear Medicine,   2019 04 28
  • Perspectives on radionuclide therapy, HOSONO Makoto, 19th Spring Meeting of Japanese Society of Nuclear Medicine,   2019 04 27 , 招待有り
  • ICRP perspectives for individualized radionuclide therapy, HOSONO Makoto, Theranostics World Congress 2019 (TWC2019),   2019 03 02 , 招待有り
  • Radiation protection for patients and practitioner in fluoroscopy-guided procedures, HOSONO Makoto, 9th Meeting of FIGHT-Japan,   2019 02 24 , 招待有り
  • Contribution to PET and RNT as Pharmacist, ASAMI Keita, HOSONO Makoto, et al., Japanese Society of Hospital Pharmacists,   2019 01 20 , 招待有り
  • ICRP C3, HOSONO Makoto, Radiation Effect Association,   2018 12 26 , 招待有り
  • Management of radiation control in short-lived radionuclides including alpha emitters, HOSONO Makoto, Japanese Society of Radiation Safety Management,   2018 12 06 , 招待有り
  • Nuclear Medicine in Oncology, HOSONO Makoto, 62nd Meeting of Fukuoka RI Conference,   2018 10 27 , 招待有り, Fukuoka RI Conference
  • Domestic Situations of Nuclear Medicine Therapy and Future Prospects, HOSONO Makoto, 56th Annual Meeting of Japanese Society of Clinical Oncology,   2018 10 19 , 招待有り, Japanese Society of Clinical Oncology
  • Radionuclide Therapy, HOSONO Makoto, 31st Annual Meeting of Japanese Society of Radiation Oncology,   2018 10 11 , 招待有り, Japanese Society of Radiation Oncology
  • Interpretation and determination of images, HOSONO Makoto, 36th Safety handling course of radioimmunotherapy using Yttrium-90 labeled anti-CD20 antibody,   2018 09 29 , 招待有り
  • Significance and application of diagnostic reference levels in ICRP recommendation (Explanation of Pub.135), HOSONO Makoto, Course held by Radiation Effect Association (ICRP Seminar),   2018 09 26 , 招待有り
  • Medical use and reasonable safety management of radionuclides (including alpha emitting radionuclides), HOSONO Makoto, 平成30年度秋期放射線安全管理研修会　放射線障害防止中央協議会,   2018 09 20 , 招待有り
  • Radiological Protection for Innovative Targeted Therapy, HOSONO Makoto, Annual Meeting of Society of Nuclear Medicine and Molecular Imaging 2018,   2018 06 26 , 招待有り, Society of Nuclear Medicine and Molecular Imaging
  • Effectiveness of targeted alpha therapy, HOSONO Makoto, 14th Workshop on safety handling of Ra-223,   2018 05 26 , 招待有り
  • Guidelines in radionuclide therapy, HOSONO Makoto, !8th Spring Meeting of JSNM,   2018 05 13 , 招待有り
  • Perspectives of radionuclide therapy, HOSONO Makoto, 18th Spring Meeting of JSNM,   2018 05 12 , 招待有り
  • From Molecular Imaging to Molecular Radiotherapy, HOSONO Makoto, 18th Spring Meeting of JSNM,   2018 05 12 , 招待有り
  • Individualized treatment planning in radionuclide therapy, HOSONO Makoto, 12th Congress of the World Federation of Nuclear Medicine and Biology,   2018 04 20 , 招待有り, 12nd Congress of the World Federation of Nuclear Medicine and Biology
  • Radiation Protection in Therapy with Radiopharmaceuticals, HOSONO Makoto, International Workshop on the Biological Effects on Radiation 2018,   2018 03 21 , 招待有り
  • Development and clinical application of targeted alpha therapy, HOSONO Makoto, Seminar at ARRONAX,   2018 01 15 , 招待有り, ARRONAX, Nantes University
  • Impact of new technology on patient radiation protection in nuclear medicine-including hybrid systems, low dose PET, HOSONO Makoto, International Conference on Radiation Protection in Medicine: Achieving Change in Practice ,   2017 12 13 , 招待有り, IAEA
  • Efficacy of Targeted Alpha Therapy, HOSONO Makoto,   2017 11 25 , 招待有り, Japan Radioisotope Association
  • Targeted Alpha Therapy in Japan, HOSONO Makoto, Seminar at Salgrenska Hospital, University Göteborg,   2017 11 08 , 招待有り, Salgrenska Hospital, University Göteborg
  • Current Status on Radionuclide Therapy, HOSONO Makoto, Joint FMU-ICRP Workshop on Radiological Protection in Medicine,   2017 10 03 , 招待有り, Fukushima Medical University and ICRP
  • Clinical evaluation and optimization of Q.Clear; a new PET reconstruction algorithm, Otani T, Hosono M, Kanagaki M, Fukumoto G, Onishi Y, Matsubara N, Kimura H, Annual Meeting of Society of Nuclear Medicine and Molecular Imaging,   2017 06 10
  • Prognostic impact of 18F-FDG PET parameters and molecular markers expression in resected non-small cell lung cancer patients, HOSONO Makoto, Kaida H, Azuma K, Kawahara A, Sadashima E, Hattori S, Akiba J, Rominger A, Takamori A, Fujimoto K, Hosono M, Ishii K, Murakami T, Ishibashi M,   2017 06 10
  • Methods of survey and decontamination of radium-223 dichloride for radionuclide therapy in clinical facilities, Hosono M, Hohara S, Inagaki M, Sakaguchi K, Yoshida S, Yamanishi H, Wakabayashi G, Matsuda T, Ito T, 10th International Symposium on Targeted Alpha Therapy,   2017 05 30
  • α線内用療法の有効性（臨床応用に関する基礎的事項）, HOSONO Makoto,   2017 05 27 , 招待有り
  • 4D-CTを用いた呼吸同期撮像法の有用性, 藤井 康司, 白髭 賢也, 竹中 達明, 細野 眞, 日本放射線技術学会総会学術大会予稿集,   2017 03
  • アルファ線核種の臨床利用における法令と指針, 細野 眞, 日本放射線技術学会総会学術大会予稿集,   2017 03
  • センチネルリンパ節SPECT/CTで肺野に集積を認めた1例, 小西達郎, 坂口健太, 細野眞, 核医学症例検討会症例集,   2017 02
  • 甲状腺乳頭癌術後のフォローのPET/CTにて皮膚に多発集積を認めた1例, 尾谷知亮, 細野眞, 金柿光憲, 乘本周平, 木村弘之, 核医学症例検討会症例集,   2017 02
  • 上顎洞術後変化としての眼窩下管拡大, 福井 秀行, 柏木 伸夫, 任 誠雲, 甲斐田 勇人, 柳生 行伸, 小塚 健倫, 細川 知紗, 熊野 正士, 鶴崎 正勝, 松木 充, 今岡 いずみ, 石井 一成, 細野 眞, 村上 卓道, Japanese Journal of Radiology,   2017 02
  • PET/CTにおける新しい再構成法Q.Clearの検討, 尾谷 知亮, 金柿 光憲, 乗本 周平, 木村 弘之, 細野 眞, Japanese Journal of Radiology,   2017 02
  • 前立腺小線源療法後1年以内死亡の3例, 横川 正樹, 中松 清志, 稲田 正浩, 福田 浩平, 建部 仁志, 石川 一樹, 立花 和泉, 門前 一, 金森 修一, 西村 恭昌, 細野 眞, Japanese Journal of Radiology,   2017 02
  • Survey and decontamination of radium-223 dichloride for alpha- particle radionuclide therapy in clinical facilities, Hosono M, Hohara S, Inagaki M, Yamanishi H, Wakabayashi G, Matsuda T, Sakaguchi K, Hanaoka K, Ito T, Annual Congress of European Association of Nuclear Medicine,   2016 10 15
  • Estimation of administered fluorodeoxyglucose activity in patients on the basis of dose equivalent rate on head by multiple regression analysis, Hosono M, Sakaguchi K, Imamura T, Takahara N, Hayashi M, Hosokawa C, Yamada M, Ishii K, Annual Congress of European Association of Nuclear Medicine,   2016 10 15
  • Survey on radionuclide therapy facilities in Japan with grants by Ministry of Health, Labour, and Welfare, Hosono M, Ikebuchi H, Nakamura Y, Nakamura N, Yanagida S, Kitaoka A, Annual Congress of European Association of Nuclear Medicine,   2016 10 15
  • 前立腺　前立腺がん診療の新技術 骨転移のある日本人の症候性去勢抵抗性前立腺癌患者への塩化ラジウム-223の第II相試験, 永森 聡, 上村 博司, 和久本 芳彰, 植村 天受, 木村 剛, 横溝 晃, 菊川 浩明, 絹谷 清剛, 細野 眞, 山口 郁, 筒井 弘一, 松永 瑛典, 松原 伸晃, 日本癌治療学会学術集会抄録集,   2016 10
  • JSNM Education, Accreditation, and Multidisciplinary Team Practice, HOSONO Makoto, Annual Meeting of Society of Nuclear Medicine,   2016 06 11 , 招待有り
  • Texture analysis for FMISO PET/CT in oncology patients receiving extra-beam radiation therapy, Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Sakaguchi K, Ishikawa K, Nakamatsu K, Kanamori S, Annual Meeting of Society of Nuclear Medicine and Molecular Imaging,   2016 06 11
  • Pretherapeutic FDG heterogeneity in tumors can predict local control in oropharyngeal cancer patients undergoing intensity-modulated radiation therapy, Hanaoka K, Hosono M, Tatebe H, Ishikawa K, Monzen H, Ishii K, Nishimura Y, Annual Meeting of Society of Nuclear Medicine Molecular Imaging,   2016 06 11
  • Dose evaluation and control for Nuclear Medicine. Joint Symposium 2: Dose evaluation and control for medical radiation exposure, HOSONO Makoto, Japan Radiology Congress,   2016 04 14 , 招待有り
  • Clinical evaluation and optimization of a new PET reconstruction algorithm Q.Clear in lung cancer, Otani T, Hosono M, Kanagaki M, Fukumoto G, Onishi Y, Matsubara N, Kimura H, ECR 2017,   2016 02 28
  • α核種による治療の現状と将来, HOSONO Makoto, 第132回関西Cancer Therapistの会,   2015 12 02 , 招待有り
  • Tumor hypoxia detected by 18F-misonidazole (F-MISO) PET/CT as a prediction of initial tumor response of radiation therapy (RT), Tachibana I, Hosono M, Inada M, Fukuda K, Tatebe H, Ishikawa K, Yokokawa M, Nakamatsu K, Kanamori S, Nishimura Y, ASTRO 2015, 57th annual meeting,   2015 10 18
  • Assessment of heart injury induced by radiation therapy for esophageal cancer using FDG-PET/CT, Hanaoka k, Hosono M, Inada M, Sakaguchi K, Shimomura K, Tamura M, Matsumoto K, Monzen H, Nishimura Y, Annual Congress of European Association of Nuclear Medicine,   2015 10 10
  • Texture analysis for tumor hypoxia visualized by FMISO PET/CT during radiation therapy, Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Ishikawa K, Sakaguchi K, Annual Congress of European Association of Nuclear Medicine,   2015 10 10
  • Therapy planning and dose prescription in radioiodine-131 therapy for hyperthyroidism using radioiodine-123 SPECT/CT imaging, Hanaoka K, Hosono M, Otsuka M, Asai Y, Okumura M, Ishii K, Murakami T, Annual Congress of European Association of Nuclear Medicine,   2015 10 10
  • Occupational radiation exposure of nursing staff in PET facility in association with performance status of patients, Hosono M, Takahara N, Yakushiji Y, Sakaguchi K, Yamada Y, Hosokawa C, Ishii K, Annual Congress of European Association of Nuclear Medicine,   2015 10 10
  • Radiation exposure of nursing staff in PET practices in correlation to performance status of patients, Hosono M, Takahara N, Yakushiji Y, Sakaguchi K, Ishii K, SNMMI 2015 Annual Meeting,   2015 06 06
  • Tumor hypoxia imaging with 18F-misonidazole (F-MISO) positron emission tomography (PET) during radiation therapy (RT), Tachibana I, Hosono M, Ishikawa K, Nakamatsu K, Matsuura T, Tatebe H, Inada M, Fukuda K, Kanamori S,Nishimura Y, International Conference of Radiation Research,   2015 05 25
  • Predictive values of 111In-ibritumomab tiuxetan SPECT/CT and 18F-FDG PET/CT in radioimmunotherapy for B-cell non-Hodgkin's lymphoma, Hanaoka K, Hosono M, Ishii K, Sakaguchi K, Tatsumi Y, Nishimura Y, 15th International Conference of Radiation Research,   2015 05 25
  • Updates and Prospects of Alpha-emitters in Targeted Radionuclide Therapy, HOSONO Makoto, 15th International Conference of Radiation Research,   2015 05 25 , 招待有り
  • Measurement and parameters of α-emitting radium-223 for radionuclide therapy in accordance with radiation protection standards, Hosono M, Hohara S, Yamanishi H, Inagaki M, Wakabayashi G, Matsuda T, Sakaguchi K, Hanaoka K, Itoh T, Annual Congress of European Association of Nuclear Medicine,   2014 10 18
  • Predictive value of heterogeneity of intratumoral In-111-Zevalin and FDG distributions for tumor response in Zevalin therapy, Hosono M, Hanaoka K, Ishii K, Sakaguchi K, Yamada M, Komeya Y, Tsuchiya N, Im SW, Tatsumi Y, Matsumura I, Annual Congress of European Association of Nuclear Medicine,   2014 10 18
  • Texture analysis of intratumoral hypoxia on FMISO PET/CT in radiation therapy, Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Ishikawa K, Annual Congress of European Association of Nuclear Medicine,   2014 10 18
  • Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition, Ishii K, Hosokawa C, Hyodo T, Wakabayashi Y, Yamada M, Kozuka T, Hosono M, Murakami T, Annual Congress of European Association of Nuclear Medicine,   2014 10 18
  • Heterogeneity of intratumoral hypoxia on FMISO PET/CT in association with local control in radiation therapy, Hosono M, Tachibana I, Nishimura Y, Hanaoka K, Kanamori S, Nakamatsu K, Shibata T, Ishikawa K, Tamura M, ASTRO 2014, 56th annual meeting,   2014 09 14
  • Measurement and radiation control of α-emitting radium-223 in radionuclide therapy for prostate cancer with bone metastases, Hosono M, Hohara S, Yamanishi H, Inagaki M, Wakabayashi G, Sakaguchi K, Hanaoka K, Itoh T, SNMMI 2014 Annual Meeting,   2014 06 07
  • Heterogeneity of intratumoral In-111-Zevalin and FDG distribution in association with therapeutic response in radioimmunotherapy for B-cell lymphoma, Hosono M, Hanaoka K, Ishii K, Sakaguchi K, Im SW, Tsuchiya N, Yoshihiro K, Tatsumi Y, and Matsumura I, SNMMI 2014 Annual Meeting,   2014 06 07
  • Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images, Hosokawa C, Ishii K, Kimura Y, Sakaguchi K, Hosono M, Murakami T, SNMMI 2014 Annual Meeting,   2014 06 07
  • Present status and future of radionuclide therapy, HOSONO Makoto, Applied physics meeting,   2013 12 14 , 招待有り
  • Association among heterogeneity of intratumoral anti-CD20 antibody distribution, glucose metabolism and therapeutic response in radioimmunotherapy for B-cell lymphoma, Hosono M, Hanaoka K, Ishii K, Im S, Sakaguchi K, Yagyu Y, Komeya Y, Tsuchiya N, Tatsumi Y, Matsumura I, Annual Congress of European Association of Nuclear Medicine,   2013 10 19
  • Therapy planning and dose prescription in radioiodine therapy for hyperthyroidism using SPECT/CT, Hosono M, Hanaoka K, Ishii K, Im S, Sakaguchi K, Yagyu Y, Matsukubo Y, Ohno Y, Ikegami H, Annual Congress of European Association of Nuclear Medicine,   2013 10 19
  • Application of NM imaging to radiation therapy, HOSONO Makoto, Tokai nuclear medicine meeting,   2013 09 28 , 招待有り
  • Present status and future of radionuclide therapy, HOSONO Makoto, Imaging meeting of South Osaka,   2013 08 21 , 招待有り
  • PET ans Radiation Safety, HOSONO Makoto, PET and nuclear medicine nurse seminar,   2013 06 22 , 招待有り
  • Heterogeneity of CD20 antigen expression and glucose metabolism in correlation with therapeutic response in radioimmunotherapy for B-cell lymphoma, Hosono M, Hanaoka K, Ishii K, Im SW, Sakaguchi K, Yagyu Y, Komeya Y, Tsuchiya N, Tatsumi Y, Matsumura I,   2013 06 08
  • Therapy planning and dose prescription in radioiodine therapy for hyperthyroidism using SPECT/CT, Therapy planning and dose prescription in radioiodine therapy for hyperthyroidism using SPECT/CT, SNMMI 2013 Annual Meeting,   2013 06 08
  • Guidelines in nuclear medicine, HOSONO Makoto, JSNM Spring Meeting,   2013 04 28 , 招待有り
  • Review on radionuclide therapy, HOSONO Makoto, JSNM Spring Meeting,   2013 04 27 , 招待有り
  • Overview of Radiation Protection in Radionuclide Therapy, HOSONO Makoto, international conference on radiation protection in medicine - setting the scene for the next decade,   2012 12
  • Radiation Protection in PET/CT, HOSONO Makoto, international conference on radiation protection in medicine - setting the scene for the next decade,   2012 12 , 招待有り
  • Three dimensional planning of radioiodine therapy for hyperthyroidism by iodine-123 SPECT/CT, Hanaoka K, Hosono M, Kurokawa T, Sakaguchi K, Yoshida S, Inoue R, Ishii K, Murakami T, Annual Congress of European Association of Nuclear Medicine,   2012 10 27
  • Prediction of tumor response by Indium-111-Zevalin SPECT/CT and FDG-PET/CT in radioimmunotherapy for B-cell non-Hodgkin lymphoma, HOSONO Makoto, Annual Congress of European Association of Nuclear Medicine,   2012 10 27
  • Radiation safety in Nuclear Medicine, HOSONO Makoto, 11th Annual General Meeting of Asian Regional Cooperative Council for Nuclear Medicine,   2012 10 24
  • Infrastructure for Radionuclide Therapy, HOSONO Makoto, 52nd Annual Meeting of Japanese Society of Nuclear Medicine,   2012 10 , 招待有り
  • PET and Radiation RIsk Communication, HOSONO Makoto, PET Summer Seminar 2012 in Shinshu,   2012 09 , 招待有り
  • Chronological Documents on the Fukushima Accident-Nuclear Emergency at the Fukushima Nuclear Reactor Accident in March 2011, HOSONO Makoto, Annual Meeting of Society of Nuclear Medicine,   2012 06 09 , 招待有り
  • Continuing Education for Certified Doctor "Guidelines", HOSONO Makoto, 12th Spring Congress of Japanese Society of Nuclear Medicine,   2012 04 28 , 招待有り
  • Seminar for Young Specialists "Radionuclide Therapy", HOSONO Makoto, 12th Spring Congress of Japanese Society of Nuclear Medicine,   2012 04 27 , 招待有り
  • Indium-111-Zevalin-SPECT/CT and FDG-PET/CT as quantitative evaluation in radioimmunotherapy for B-cell non-Hodgkin’s lymphoma, Annual Congress of the European Association of Nuclear Medicine,   2011 10 15 , Annual Congress of the European Association of Nuclear Medicine
  • Measurement of functional thyroid weight using I-123 SPECT/CT as planning for radioiodine therapy, Hanaoka K, Hosono M, Shimosegawa E, Hatazawa J, EANM’11 annual congress of European Society of Nuclear Medicine,   2011 10 15
  • A prospective Clinical Trial on Tumor Hypoxia Imaging with 18F-misonidazole (F-MISO) positron Emission Tomography (PET), Tachibana I, Nishimura Y, Shibata T, Kanamori S, Nakamatsu K, Tamura M, Koike R, Nishikawa T, Ishikawa K, Hosono M, 53rd annual meeting of ASTRO,   2011 10 02
  • Clinical impact of CT attenuation correction by SPECT/CT in brain perfusion images, Ishii K, Hanaoka K, Okada M, Kumano S, Komeya Y, Tsuchiya N, Hosono M, Murakami T, SNM 2011 Annual Meeting,   2011 06 04
  • The iliac wing sign: The feasibility for diagnosis of bone and/or soft-tissue injury of the pelvis and hips, Kakigi T, Hosono M, Shimono T, Hiraoka T, Nishimura K, ECR 2011,   2011 03 03
  • FDG and F-MISO PET-CT in the treatment planning for radiation therapy., the First International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular,   2011 02 , the First International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular
  • A Prospective Clinical Trial of Tumor Hypoxia Imaging with 18F-misonidazole (F-MISO) Positron Emission Tomography (PET), American Society for Radiation Oncology 53rd Annual Meeting,   2011 , American Society for Radiation Oncology 53rd Annual Meeting
  • Definition of target volumes by PET/CT for radiation therapy planning using moving phantom, Hanaoka K, Hosono M, Okubo M, Usami K, Okumura M, Sumita M, Nishimura Y, Murakami T, EANM'10,   2010 10 09
  • Assessment of lymph node metastasis in esophageal cancer with SUV correction based on count recovery on 18F-FDG PET/CT., SNM2009 Annual Meeting,   2009 06 13 , SNM2009 Annual Meeting
  • Measurement of regional cerebral blood flow associated with cilostazol tehrapy in vascular dementia., SNM2009 Annual Meeting,   2009 06 13 , ISM 2009 Annual Meeting
  • Malignant Lymphoma Post Therapy:Usefulness and Pitfalls Using FDG-PET/CT Compared to CT, MRI, and Ga Sxintigraphy., 94rd Radiological Society of North America,   2008 12 , 94rd Radiological Society of North America
  • CT appearance of post OOKP procedure.,   2008 10
  • Adrenal masses: The additional value of FDG-PET/CT for cancer patients, Okada M, Hosono M, Shimono T, Kumano S, Usami K, Yamazoe Y, Komeya Y, Kagawa Y, Tsuchiya N, Murakami T, 55th annual meeting of Society of Nuclear Medicine,   2008 06 14 , 55th annual meeting of Society of Nuclear Medicine
  • Evaluation of lymph node metastases in esophageal cancer with SUV correction for partial volume effect on FDG PET/CT, 55th annual meeting of Society of Nuclear Medicine,   2008 06 , 55th annual meeting of Society of Nuclear Medicine
  • New insight into the pathogenesis of malignant lymphoma by integrated FDG-PET/CT, 55th annual meeting of Society of Nuclear Medicine,   2008 06 , 55th annual meeting of Society of Nuclear Medicine
  • Utility of partial volume correction based on count recovery on FDG PET/CT in lymph node metastasis of lung cancer, 55th annual meeting of Society of Nuclear Medicine,   2008 06 , 55th annual meeting of Society of Nuclear Medicine
  • Static and moving phantom studies for treatment planning in an integrated PET/CT system., the 49th Annual Meeting of the American Society for Therapeutic Radiology and Oncology,   2007 10 , the 49th Annual Meeting of the American Society for Therapeutic Radiology and Oncology
  • Assessment of lymph node metastasis in lung cancer with SUV correction based on count recovery in FDG PET/CT., 54th Annual Meeting of Society of Nuclear Medicine.,   2007 06 , 54th Annual Meeting of Society of Nuclear Medicine.
  • Effect of attenuation correction on wall motion quantification in Tl-201 ECG-gated myocardial SPECT. Assessment of lymph node metastasis in lung cancer with SUV correction based on count recovery in FDG PET/CT., 54th Annual Meeting of Society of Nuclear Medicine.,   2007 06 , 54th Annual Meeting of Society of Nuclear Medicine.
  • Hepatocellular carcinoma, cholangiocarcinoma, and liver metastasis by multimodality imaging: MSCT, US, MRI, and PET, Okada M, Yagyu Y, Murakami T, Numata K, Takeuchi R, Hosono M, 92nd Scientific Assembly and Annual Meeting RSNA,   2006 11 26
  • Biliary obstruction: Value of imaging for choledocholithiasis, pancreas, and bile duct cancer, Okada M, Im S, Yagyu Y, Shimono T, Murakami T, Hosono M, 92nd Scientific Assembly and Annual Meeting RSNA,   2006 11 26
  • MR imaging, CT, and PET in patients with cancer of peritoneum and abdominal wall, Komeya Y, Okada M, Hosono M, Takeuchi R, Matsumura K, Murakami T, 92nd Scientific Assembly and Annual Meeting RSNA,   2006 11 26
  • Abdominal calcifications: Pictorial review of liver, spleen, gallbladder, kidney, peritoneum, and vascular structure lesions, Im S, Okada M, Yoh T, Tsuchiya N, Hosono M, Murakami T, 92nd Scientific Assembly and Annual Meeting RSNA,   2006 11 26
  • PET first : Malignant Lymphoma., 92nd Radiological Society of North America.,   2006 11 , 92nd Radiological Society of North America.
  • Early cancer diagnosis in healthy population, an epidemiological dilemma, Takeuchi R, Sengoku T, Okada M, Hosono M, Ohta H, Matsumura K, Annual Congress of EANM 2006,   2006 10 01
  • Comparison of adrenal cortical scintigraphy, CT and chemical-shift MRI for differential diagnosis of adrenal cortical functioning adenoma, Yoh T, Hosono M, Tsuchiya N, Komeya Y, Hanada K, Im SW, Ashikaga R, Shimono T, Yagyu Y, Hiroi K, 53rd annual meeting of Society of Nuclear Medicine,   2006 06 03
  • Difference of brain surface images between with and without attenuation correction for application to 3D-SSP technique, Hanada K, Hosono M, Hitomi Y, Yagyu Y, Komeya Y, Funatsu K, Takahashi E, Kudo T, Hitomi K, Nishimura Y, 53rd annual meeting of Society of Nuclear Medicine,   2006 06 03
  • Quantitative assessment of wall motion and thickening on TL-201 stress myocardial gated SPECT for detecting ischemia, Komeya Y, Hosono M, Yoh T, Tsuchiya N, Hanada K, Ashikaga R, Yagyu Y, Koike R, Hiroi K, Kudo K, 53rd annual meeting of Society of Nuclear Medicine,   2006 06 03
  • Quantification of left ventricular systolic and diastolic function using TL-201 gated SPECT and derivative analysis for detecting ischemia, Komeya Y, Hosono M, Yoh T, Tsuchiya N, Hanada K, Im SW, Ashikaga R, Yagyu Y, Okada M, Shimono T, 53rd annual meeting of Society of Nuclear Medicine,   2006 06 03
  • Statistical image analysis of regional cerebral blood flow in patients of mild cognitive impairment and relation of MMSE subgroups, Hanada K, Hosono M, Hitomi Y, Yagyu Y, Komeya Y, Kitahata D, Ohga Y, Kudo T, Hitomi K, Nishimura Y, 53rd annual meeting of Society of Nuclear Medicine,   2006 06 03
  • A case of granular cell carcinoma of the kidney,   2006 05
  • Management of acute reactions to contrast media in kinki univ. medical hospital,   2006 04
  • Management of acute reactions to contrast media in kinki univ. medical hospital,   2006 04
  • Management of acute reactions to contrast media in kinki univ. medical hospital,   2005 10
  • Correlation of regional cerebral blood flow and MMSE subgroups in patients of mild cognitive impairment, Hanada K, Hosono M, Hitomi Y, Yagyu Y, Kirime E, Komeya Y Koike R, Kitahata D, Kudo T, Hitomi K, Nishimura Y, 52nd annual meeting of Society of Nuclear Medicine,   2005 06 18 , Society of Nuclear Medicine 52nd Annual Meeting
  • Assessment of left ventricular systolic and diastolic function using Tl-201 gated SPECT for detectiong ischemia, Komeya Y, Hosono M, Kudo T, Koike R, Hiroi K, Yagyu Y, Nin Seiun, Hanada K, Nishimura Y, 52nd annual meeting of Society of Nuclear Medicine,   2005 06 18
  • Wall motion and thickening measurement on Tl-201 stress myocardial gated SPECT for detecting ischemia, Komeya Y, Hosono M, Kudo T, Koike R, Hiroi K, Yagyu Y, Hanada K, Nishimura Y, 52nd annual meeting of Society of Nuclear Medicine,   2005 06 18
  • Quantification of attenuation correction in Tl-201 myocardial SPECT,   2005 04
  • Diagnostic effectiveness of Alzheiwer disease by 3D-SRT,   2004 11
  • A trial to make a normal database of 99mTc-HMPAO SPECT in Kinki University Hospital,   2004 07
  • Investigation of a diagnosis of Alzheimer disease by VOI classic,   2004 06
  • Disease severity and diagnostic performance of nuclear medicine physicians are not related in brain perfusion SPECT inpection for Alzheimer's disease,   2004 06
  • Regional CBF change and detection of vasospasm in subarachnoid hemorrhage, SNM,   2004 06 , SNM
  • Wall motion quantification on Tl-201 gated SPECT for detecting ischemia, SNM,   2004 06 , SNM
  • Different regional cerebral blood flow patterns in chronic schizophrenia with and without delusion, SNM,   2004 06 , SNM
  • Utility of 3D-SRT in a diagnosis of Alzheimer disease,   2004 04
  • Different regional cerebral blood flow patterns in chronic schizophrenia with and without delusion., Society of Nuclear Medicine 51nd Annual Meeting,   2004 , Society of Nuclear Medicine 51nd Annual Meeting
  • Regional cerebral blood flow in assessment of major depression and Alzheimer's disease in early elderly., Society of Nuclear Medicine 51nd Annual Meeting,   2004 , Society of Nuclear Medicine 51nd Annual Meeting
  • Three-dimensional stereotacitc surface projection of brain perfusion SPET enhances diagnosis of Alzheimer’s disease,   2003 08
  • Global cerebral blood flow changes measured by brain perfusion SPECT immediately after whole brain irradiation, ECNM,   2003 06 , ECNM
  • 201Tl SPECT and CT fusion in thoracic malignancy, SNM,   2003 06 , SNM
  • Isothiocyanato-dioxo-carboxymethyl-tetraazacyclotridecane as a new chelate to label antibody with technetium-99m, SNM,   2003 06 , SNM
  • Evaluation of regional CBF in subarachnoid hemorrhage using 99mTc-ECD, SNM,   2003 06 , SNM
  • Diagnostic performance of brain perfusion SPECT for Alzheimer's disease: comparison between visual interpretation and three-dimensional sterotactic surface display, SNM,   2003 06 , SNM
  • Brain perfusion SPET in Alzheimer’s disease has equivalent diagnostic power as MRI, ECNM,   2002 09 , ECNM
  • Cerebral blood flow measurements by Tc-99m ECD and phase contrast MR, ECNM,   2002 09 , ECNM
  • Quantitative measurement of regional pulmonary blood flow in normal volunteers, SNM,   2002 06 , SNM
  • Detection of esophageal cancer and prediction of response to chemoradiotherapy, SNM,   2002 06 , SNM
  • Multiple marker image histogram analyses optimized for diagnostic performance: demonstration for SPECT lung V/Q, SNM,   2002 06 , SNM
  • Diagnostic performance of nuclear medicine physicians interpreting brain perfusion SPECT in Alzheimer’s disease and other dementias, RSNA,   2001 11 , RSNA
  • Accuracy of left ventricular ejection fraction determined by pFAST, PC-based software different from Germano’s method, for quantitative EKG-gated myocardial perfusion SPECT (QGS), RSNA,   2001 11 , RSNA
  • Regional cerebral blood flow quantification SPECT in aneurysmal subarachnoid hemorrhage, RSNA,   2001 11 , RSNA
  • Comparison of cine phase contrast MR and 99mTc-ECD for quantification of cerebral blood flow, RSNA,   2001 11 , RSNA
  • Regional CBF quantification in aneurysmal subarachnoid hemorrhage, Hosono M, Machida K, Matsui T, Honda N, Takahashi T, Kashimada A, Shimizu Y, Osada H, Dei S, Ohmichi M, Asano T, ECNM,   2001 08 25 , ECNM
  • Value of cerebral blood flow spet in dementia compared with magnetic resonance imaging, Machida K, Honda N, Hosono M, Shimizu Y, Kosuda S, Matsuda H, Ohshima M, Momose T, Koizumi K, Matsumoto H, Hashimoto J, Congress 2001 of European Association of Nuclear Medicine,   2001 08 25
  • Creation of quantitative regional pulmonary blood flow map by concurrent use of MR angiograpy and perfusion SPECT, Honda N, Machida K, Osada H, Hosono M, Takahashi T, Kamano T, Kashimada A, Shimizu Y, Watanabe W, Dei S, Oomichi M, Usui Y, Hondo M, Okada T, Nishimura K, Ootawa N, Tanaka A, Takahashi M, 48th annual meeting of Society of Nuclear Medicine,   2001 06 23
  • Relationship between 99mTc-GSA scintigraphy and portal circulation in patients with hepatocellular carcinoma complicated by liver cirrhosis, Osada H, Machida K, Honda N, Hosono M, Takahashi T, Kashimada A, Shimizu Y, Watanabe W, Ohmichi M, 48th annual meeting of Society of Nuclear Medicine,   2001 06 23
  • Fractal analysis for ventilation/perfusion ratio map in differentiating lung diseases, Dei S, Machida K, Honda N, Hosono M, Takahashi T, Kashimada A, Shimizu Y, Osada H, Ohmichi M, Ohtawa N, Takahashi M, Tanaka A, Thie JA, 48th annual meeting of Society of Nuclear Medicine,   2001 06 23
  • Detection of changes in regional CBF in subarachnoid hemorrhage using 99mTc-ECD, Hosono M, Machida K, Matsui T, Honda N, Takahashi T, Kashimada K, Shimizu Y, Osada H, Dei S, Ohmichi M, Ootawa N, Okada T, Nishimura K, Asano, T, 48th annual meeting of Society of Nuclear Medicine,   2001 06 23
  • Changes of blood flow measured with Tc-99m ethyl cysteinate dimer in detection of vasospasm, Hosono M, Machida K, Matsui T, Honda N, Takahashi T, Kashimada A, Shimizu Y, Dei S, Ohmichi M, Asano T, Congress 2000 of European Association of Nuclear Medicine,   2000 09 02
  • Inexpensive tool for quantification of left ventricular ejection fraction from gated-myocardial perfusion SPET, Machida K, Honda N, Hosono M, Shimizu Y, Nishimura K, Congress 2000 of European Association of Nuclear Medicine,   2000 09 02
  • Ventilation/perfusion ratio maps with 99mTc-technegas and 99mTc-MAA in lung diseases, Dei S, Machida K, Honda N, Hosono M, Takahashi T, Kashimada A, Shimizu Y, Osada H, Toyoda H, Watanabe W, Ohmichi M, Ootawa N, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • Quantification of regional lung perfusion using 99mTc-MAA SPECT and cine phase contrast MR angiography, Osada H, Machida K, Honda N, Hosono M, Takahashi T, Kashimada A, Shimizu Y, Watanabe W, Ohmichi M, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • Detection of intrapulmonary shunting in liver cirrhosis by quantitative 99mTc MAA scintigraphy, Hosono M, Machida K, Honda N, Takahashi T, Kashimada A, Shimizu Y, Osada H, Dei S, Toyoda H, Ohmichi M, Ochiai K, Hondo M, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • Quantitative gated SPECT with 99mTc tetrofosmin is more accurate than echocardiography in determining left ventricular ejection fraction, Nishimura K, Machida K, Honda N, Hosono M, Takahashi T, Kashimada A, Shimizu Y, Osada H, Toyoda H, Watanabe W, Dei S, Ohmichi M, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • 99mTc-Pyrophosphate SPECT is more sensitive for functional recovery after acute myocardial infarction than rest/redistribution 201Tl SPECT, Shimizu Y, Machida K, Honda N, Hosono M, Takahashi T, Kashimada A, Osada H, Toyoda H, Watanabe W, Dei S, Ohmichi M, Ootawa N, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • Myocardial wall thickening idex on 99mTc tetrofosmin gated SPECT for quantitative evaluation of regional wall motion, himizu Y, Machida K, Honda N, Hosono M, Takahashi T, Osada H, Toyoda H, Ohmichi M, Kato T, Maruyama Y, Tanaka S, Yoshimoto N, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • Interobsever variation in differential diagnosis of dementia by cerebral blood flow SPECT, Honda N, Machida K, Matsuda H, Ohshima M, Momose T, Matsumoto T, Hosono M, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • Quantification of cerebral blood flow with 99mTc ethyl cysteinate dimer for detecting vasospasm in aneurysmal subarachnoid hemorrhage, Hosono M, Machida K, Matsui T, Honda N, Takahashi T, Kashimada A, Shimizu Y, Osada H, Dei S, Toyoda H, Ohmichi M, Asano T, 47th annual meeting of Society of Nuclear Medicine,   2000 06 03
  • mCBF quantification and SPECT for detecting vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH) using Tc-99m ethyl cysteinate dimer (ECD), Hosono M, Machida K, Honda N, Takahashi T, Takahashi T, Kashimada A, Osada H, Shimizu Y, Dei S, Toyoda T, Matsui T, Asano T, 46th annual meeting of Society of Nuclear Medicine,   1999 06 06
  • Ventilation SPECI is superior to CT ventilation map by non-radioactive xenon inhalation, Honda N, Machida K, Hosono M, Takahashi T, Takahashi T, Kamano T, Kashimada K, Osada H, Shimizu Y, Watanabe W, Dei S, Oomichi M, 46th annual meeting of Society of Nuclear Medicine,   1999 06 06
  • Quantification of regional pulmonary arterial blood flow using Tc-99m-MAA SPECT and cine phase contrast MR angiography, Osada H, Machida K, Honda N, Takahashi T, Hosono M, Takahashi T, Kashimada A, Shimizu Y, 46th annual meeting of Society of Nuclear Medicine,   1999 06 06
  • Quantitative evaluation of regional wall motion by a wall thickening index of gated Tc-99m-tetrofosmin myocardial perfusion tomography, Shimizu Y, Machida K, Honda N, Hosono M, Takahashi T, Takahashi T, Kamano T, Kashimada A, Osada H, Watanabe W, Dei S, Oomichi M, 46th annual meeting of Society of Nuclear Medicine,   1999 06 06
  • Quantitative monitoring of cerebral blood flow (CBF) in patients with aneurysmal subarachnoid hemorrhage (SAH) with Tc-99m ethyl cysteinate dimer (ECD), Hosono M, Machida K, Honda N, Takahashi T, Takahashi T, and Matsui T, 84th scientific assembly and annual meeting of RSNA,   1998 11 29
  • Assessment of regional wall motion by gated myocardial perfusion tomography with 99mTc-tetrofosmin, Machida K, Honda N, Takahashi T, Hosono M, Takahashi T, Kamano T, Kashimada A, Osada H, Shimizu Y, Iwase T, Toyoda H, Ogawa K, Watanabe W, Dei S, Ohmichi M, Ohiai K, Takishima T, Joint Congress of the European Association of Nuclear Medicine and the World Federation of Nuclear Medicine and Biology,   1998 08 30
  • Detection of vasospasm in patients with aneurysmal subarachnoid hemorrhage (SAH) by non-invasive cerebral blood flow quantification, Hosono M, Machida K, Honda N, Takahashi T, Takahashi T, Dei S, Shimizu Y, Kamano T, Kashimada A, Osada H, Matsui T, Asano T, Joint Congress of the European Association of Nuclear Medicine and the World Federation of Nuclear Medicine and Biology,   1998 08 30
  • Localization of small-cell lung cancer xenograft by two-step method with bispecific antibody and bivalent hapten, Hosono M, Hosono MN, Kraeber-Bodéré F, Devys A, Thédrez P, Faivre-Chauvet A, Machida K, Gautherot E, Barbet J, Chatal JF, Joint Congress of the European Association of Nuclear Medicine and the World Federation of Nuclear Medicine and Biology,   1998 08 30
  • Utility of thallium-201 SPECT in determining site of image-guide biopsy for patients with thoracic tumor, Ogawa K, Machida K, Honda N, Takahashi T, Hosono M, Kamano T, Kashimada A, Shimizu Y, Osada H, Iwase S, Toyoda H, Watanabe W, Ohmichi M, Dei S, Ochiai T, 45th annual meeting of Society of Nuclear Medicine,   1998 06 01
  • Diagnostic abilities of high resolution CT, dynamic CT, and Tl-201 SPECT for evaluation of pulmonary masses, Kashimada A, Machida K, Honda N, Hosono M, Takahashi T, Takahashi T, Kamano T, Shimizu Y, Osada H, Iwase S, Toyoda H, Ogawa K, Watanabe W, Ohmichi M, Dei S, Ochiai T, 45th annual meeting of Society of Nuclear Medicine,   1998 06 01
  • Spiral CT of stapes: spectrum of findings in normal and abnormal ears, Osada H, Machida K, Honda N, Takahashi T, Hosono M and Kamano T, 83rd scientific assembly and annual meeting of RSNA,   1997 11 30
  • Flow patterns of ascending aorta in aortic regurgitation analysed by velocity-encoding MR imaging, Honda N, Machida K, Takahashi T, Kamano T, Hosono M and Kashimada A, 83rd scientific assembly and annual meeting of RSNA,   1997 11 30
  • Transient hypersecretion of catecholamines associated with exacerbation of symptoms after I-131 MIBG therapy in patients, Sakahara H, Saga T, Yao Z, Nakamoto Y, Sato N, Hosono M, Endo K, Konishi J, 44th annual meeting of Society of Nuclear Medicine,   1997 06 01
  • Portal flow measurement with velocity-encoding MR imaging in diffuse liver diseases, Honda N, Machida K, Osada H, Takahashi T, Hosono M and Kamano T, 82nd scientific assembly and annual meeting of RSNA,   1996 12 01
  • Simultaneous dual-isotope Tc-99m-tetrofosmin and Tl-201 SPECT in evaluation of primary lung cancer, Hosono M, Machida K, Honda N, Takahashi T, Kamano T and Kashimada A, 82nd scientific assembly and annual meeting of RSNA,   1996 12 01
  • Value of Tl-201 and I-123-BMIPP dual energy cardiac SPECT in patients with chronic renal failure on hemodialysis, Toyoda H, Machida K, Honda N, Hosono M, Takahashi T, Kamano T, Shimizu Y, Osada H, Iwase T, Toyoda H, Ogawa K, Watanabe W, S Dei and Kasahara N, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • Preliminary study of measurement of regional pulmonary flow using MRI and Tc-99m-MAA lung perfusion scintigraphy, Osada H, Machida K, Honda N, Mamiya T, Takahashi T, Hosono M, Kamano T, Kashimada A, Shimizu Y, Iwase T and Toyoda H, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • Evaluation of I-123 iomazenil SPECT for cerebrovascular disease:comparison with brain perfusion SPECT and brain MRI, Kashimada A, Machida K, Honda N, Hosono M, Takahashi T, Kamano T, Shimizu Y, Osada H, Iwase T, Toyoda H, Ogawa K and Watanabe W, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • Whole body scan by 3-head SPECT system: comparison of 3-projection Tc-99m-MDP bone scan with conventional 2-projection scan, Honda N, Machida K, Hosono M, Shimizu Y, Toyoda H, Sakurai K, Takahashi T, Kamano T, Kashimada A, Osada H, Iwase T, Watanabe W, Ogawa K and Dei S, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • Cinematic display of ECG-gated Tc-99m-tetrofosmin myocardial perfusion SPECT, Shimizu Y, Machida K, Honda N, Hosono M, Takahashi T, Kashimada A, Osada H, Iwase T, Toyoda H, Ogawa K, Watanabe W and Dei S, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • Targeting of small-cell lung cancer xenografts by Re-188-labeled monoclonal antibodies, Hosono MN, Hosono M, Mishra AK, Faivre-Chauvet A, Barbet J, Gautherot E, Knapp FF, Yamada R and Chatal JF, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • Evaluation of three-head gamma camera SPECT images in 6 institutes, Hosono M, Machida K, Honda N, Matsumoto T, Togawa T, Yui N, Murata H, Maruno H, Hatano O, Uno K, Ohta M, Oyamada H, Kubo K, Ishii K, Nishimaki H, Horiike S, Matsunaga K, Mori Y and Iinuma T, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • Two-step targeting of medullary thyroid cancer by bivalent hapten and bispecific antibody in mice, Hosono M, Hosono MN, Kraeber-Bodéré F, Devys A, Thedrez P, Barbet J, Gautherot E, Machida K and Chatal JF, The 6th Asia and Oceania Congress of Nuclear Medicine and Biology,   1996 09 30
  • BMIPP and MIBG SPET finding in myotonic dystrophy, Honda N, Machida K, Hosono M, Mamiya T, Takahashi T, Kamano T, Kashimada A, Osaka H, Shimizu Y, Iwase T, Yoyoda H, Kinoshita S, Congress 1996 of European Association of Nuclear Medicine,   1996 09 14
  • Localization of small-cell lung cancer xenografts by Re-188-labeled monoclonal antibodies, Hosono MN, Hosono M, Mishra AK, Faivre-Chauvet A, Barbet J, Gautherot E, Knapp FF, Yamada R, Machida K and Chatal JF, Congress 1996 of European Association of Nuclear Medicine,   1996 09 14
  • Radioimmunodetection of medullary thyroid cancer by bivalent hapten and bispecific antibody in mice, Hosono M, Hosono MN, Kraeber-Bodéré F, Devys A, Thedrez P, Barbet J, Gautherot E, Machida K and Chatal JF, Congress 1996 of European Association of Nuclear Medicine,   1996 09 14
  • Preliminary study of measurement of focal pulmonary flow using MRI and 99mTc-MAA lung perfusion scintigraphy, Osada H, Machida K, Honda N, Mamiya T, Takahashi T, Hosono M, Kamano T, Kashimada A, Shimizu Y, Iwase T and Toyoda H, 43rd annual meeting of Society of Nuclear Medicine,   1996 06 03
  • Targeting of small-cell lung cancer by octreotide labeled with I-125, In-111, and Re-188 in a mouse model, Hosono M, Hosono MN, Haberberger T, Zamora PO, Guhlke S, Bender H, Knapp FF Jr, Biersack HJ, Congress 1995 of European Association of Nuclear Medicine,   1995 08 26
  • Immunoscintigraphy of ovarian cancer using a monoclonal antibody to CA125, akahara H, Hosono M, Kobayashi H, Yao Z, Saga T, Yano S, Endo K, Mori T and Konishi J, 42nd annual meeting of Society of Nuclear Medicine,   1995 06 12
  • Imaging of small-cell lung cancer xenografts with I-125, In-111 and Re-188 octreotides, Hosono M, Hosono MN, Haberberger T, Zamora PO, Guhlke S, Bender H, Knapp FF Jr, Biersack HJ, 42nd annual meeting of Society of Nuclear Medicine,   1995 06 12
  • Improved biodistribution of radiolabeled biotinylated monoclonal antibody followed by the injection of avidin as a "chase", Kobayashi H, Sakahara H, Hosono M, Yao Z-S, Yamamuro T, Toyama S, Endo K and Konishi J, 6th World Congress of the World Federation Nuclear Medicine and Biology,   1994 10 23
  • Scintigraphic detection of colorectal carcinoma xenografts with Re-188 labeled monoclonal antibody, Hosono M, Hosono MN, Bender H, Zamora PO, Guhlke S, Knapp FF Jr and Biersack HJ, 6th World Congress of the World Federation Nuclear Medicine and Biology,   1994 10 23
  • Radioimmunotargeting with Re-188 labeled monoclonal antibody in mice bearing colorectal carcinoma xenografts, Hosono MN, Hosono M, Zamora PO, Guhlke S, Bender H, Biersack HJ, Onoyama Y, Ochi H and Konishi J, Congress 1994 of European Association of Nuclear Medicine, Düsseldorf,   1994 08 20
  • Localization of infiltration of human leukemia cells in SCID mice, osono M, Kondo A, Yao Z, Kobayashi H, Hosono MN, Sakahara H, Imada K, Okuma M, Uchiyama T and Konishi J, ongress 1994 of European Association of Nuclear Medicine,   1994 08 20
  • Detection of proliferation sites of ATL cells in SCID mice, Hosono M, Kondo A, Yao Z, Kobayashi H, Hosono MN, Sakahara H, Imada K, Okuma M, Uchiyama T and Konishi J, 41st annual meeting of Society of Nuclear Medicine,   1994 06 05

Awards & Honors

  •   2009 10 , Japanese Society of Nuclear Medicine, 48th Japanese Society of Nuclear Medicine Award
  •   2008 12 , RSNA, Certificate of Merit, Malignant lymphoma post therapy: usefulness and pitfalls using FDG-PET/CT compared to CT, MRI, and Ga scintigraphy
  •   2007 11 , RSNA, Certificate of Merit, Wide spectrum of malignant lymphoma: new insight into the pathogenesis of lymphoid malignancies in PET-CT and MRI
  •   2006 12 , RSNA, Certificate of Merit, MR imaging, CT, and PET in patients with cancer of peritoneum and abdominal wall
  •   1997 10 , Atomic Energy Research Foundation in Medicine, Award, Atomic Energy Research Foundation in Medicine

Research Grants & Projects

  • Ministry of Health, Labour and Welfare, Workers' illnessclinical research project , Survey and research on the actual conditions of radiation exposure and reduction in radiation work in medicine, HOSONO Makoto
  • Ministry of Health, Labour and Welfare, Health and Labour Sciences Research Grants, Research on standards for radiation protection in conventional and innovative radiological practices, HOSONO Makoto
  • Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Scientific Research (C), Dosimetry and personalized therapy in radionuclide therapy using novel nuclides, HOSONO Makoto
  • Nuclear Regulatory Agency, Project for promotion of radiation safety regulations , Research on reasonable radiation management for short-lived alpha emitters, HOSONO Makoto
  • Ministry of Health, Labour and Welfare, Ministry of Health, Labour and Welfare: Health and Labour Sciences Research Grants, Research on radiation protection for novel therapeutic procedures, HOSONO Makoto
  • Ministry of Education,Culuture,Sports,Science and Technology, Grant-in-Aid for Scientific Research, Treatment of metastatic bone diseases by alpha-emitter Ra-223, HOSONO Makoto
  • Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), Imaging of proliferative ability and hypoxia of tumor in radioimmunotherapy, Makoto HOSONO, In patients with CD20 positive B-cell non-Hodgkin lymphoma who underwent yttrium-90 labeled anti-CD20 ibritumomab tiuxetan therapy, glucose metabolism by FDG and hypoxia by FMISO were evaluated with PET/CT before and after therapy, and changes were analyzed over time. Antigen expression of CD20 was also evaluated by SPECT/CT using indium-111 labeled anti-CD20 antibody. Association of glucose metabolism, hypoxia, and CD20 expression with therapeutic response was analyzed.
  • Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), Optimization of radioimmunotherapy with radiolabeled anti-HER2 antibody, Makoto HOSONO, Molecular targeting concept and technology have recently been established and applied to disease entities, and have proved efficient and indispensable in some pathological status. As one of molecular targeting applications, radioimmunoscintigraphy and radioimmunotherapy which use radiolabeled monoclonal antibodies recognizing malignancy have successfully been undertaken in laboratory studies and clinical applications. The purpose of this study was to develop tumor imaging and therapy using molecular targeting techniques. To conduct radioimmunotherapy with radiolabeled anti-HER2 antibody in patients, we investigated conditions of radiolabeling techniques of potentially therapeutic radionuclides and tumor-directed antibodies. Chelating agents having macrocycle structures are suitable for radioimmunotherapy because of conjugation stability. Parameters of radiolabeling for chelates have been determined and optimized in animal models with human cancers. Distributions of malignant cells were studied in animal models using radiolabeling of cancer cells. A liver metastasis model was constructed by injecting radiolabeled cancer cells into the portal vein or spleen. Biodistribution of cancer cells was determined by tracer studies using radiolabeled antibodies. The obtained data were used for analyzing parameters in forthcoming radioimmunotherapy. Basic safety standards in radiological protection were considered for prospects of radionuclide therapy in clinical facilities. In conclusion, our study demonstrates significant findings of basic investigation as molecular imaging and therapy are increasingly applied to clinical practices.
  • Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), Radio immunotherapy of malignant tumors by pretargeting, Makoto HOSONO, The "affinity enhancement system", a two-step targeting technique using bispecific antibody and radiolabeled bivalent hapten, has been reported to be useful for the targeting of carcinoembryonic antigen-expressing tumors. The purpose of this study was to evaluate the efficacy of this method for targeting human small cell lung cancer using an antineural cell adhesion molecule antibody.Antineural cell adhesion molecule/antihistamine bispecific anti-body NKI NBLIJ79 was prepared by coupling an equimolecular quantity of a Fab' fragment of NK1NBL1 to a Fab fragment of antihistamine 679. Athymic mice inoculated with NC1-H69 small cell lung cancer cells expressing neural cell adhesion molecule were administered bispecific antibody and then 48 h later 1251-labeled bivalent histamine hapten. 1251-labeled in tact NKINBLI was injected into other groups of mice. Biodisributions were examined as a function of time.In mice of the two-step targeting, tumor-to-blood, tumor-to-liver and tumor-to-kidney ratios were 1.4 ± 1.1, 10.8 ± 13.2 and 4.6 ± 4.7, respectively, at 5 h, whereas 1251-labeled NK1NBL1 showed tumor-to-blood, tumor-to-liver and tumor-to-kidney ratios of 0.3 ± 0.1, 1.1 ± 0.2 and 0.9 ± 0.1, respectively, at 5 h. Dosimetry showed that tumor-to-liver and -to-bone marrow ratios of absorbed irradiation doses were 14.3 and 16.8 for the two-step method and 4.2 and 2.6 for the one-step method. This suggested that the affinity enhancement system could enhance the therapeutic potential of the antineural cell adhesion molecule antibody NK1NBL1.This two-step targeting method seems promising for the diagnosis and therapy of small cell lung cancer by giving enhanced tumor-to-normal tissue contrast.
  • Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), Clinical efficacy of brain blood flow SPECT in the diagnosis of pochiatric disorders in the aged, Kikuo MACHIDA, Brain perfusion SPECT (BP-SPECT) has characteristic patterns of abnormality enabling differential diagnosis of dementia. The purpose was to measure inter-obserYer variations in diagnosis of dementia using BP-SPECT. BP-SPECT images of 57 cases, 19 of Alzheimer s Disease (AD) eight of multi-infarct dementia (MID), three of Pick's disease, five of other dementias and 22 normal controls, were interpreted by ten nuclear medicine physicians of variable experience before and after the addition of MRl. The physicians independently rated diagnoses that were listed beforehand according to a 5-point s...
  • Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)), EVALUATION OF ACCURACY OF SPECT IN THE DIAGNOSIS OF BRAIN TUMOR, Kikuo MACHIDA, Fifteen-four studies of ^<20l>T1 brain tumor SPECT were independently interpreted by 9 nuclear medicine physicians with and without reference magnetic resonance images in 2 separate sessions to define an effect of referring images, and inter-observer variations. The physicians were requested to detect foci of abnormal deposits, and to discriminate whether they were malignant or not according to 5-grade scaling of subjective diagnostic confidence. Receiver-operating characteristics (ROC) analysis was performed. Mean sensitivity for presence of lesions (SFP), and sensitivity and specifcity fo...
  • Grant-in-Aid for Scientific Research, Radioimmunotherapy