KINDAI UNIVERSITY


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FUKUSHIMA Nobuyuki

Profile

FacultyDepartment of Life Science / Graduate School of Science and Engineering Research
PositionProfessor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/656-fukushima-nobuyuki.html
URL
Mail
Last Updated :2020/04/05

Research Activities

Research Areas

  • Life sciences, Pharmacology
  • Life sciences, Pharmaceuticals - health and biochemistry
  • Life sciences, Developmental biology
  • Life sciences, Cell biology
  • Life sciences, Neuroscience - general

Published Papers

  • Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells., Takahashi K, Fukushima K, Tanaka K, Minami K, Ishimoto K, Otagaki S, Fukushima N, Honoki K, Tsujiuchi T, Experimental cell research, Experimental cell research, 369(2), 316 - 324, Aug. 2018 , Refereed
  • Involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells., Takahashi K, Fukushima K, Onishi Y, Minami K, Otagaki S, Ishimoto K, Fukushima N, Honoki K, Tsujiuchi T, Experimental cell research, Experimental cell research, 369(1), 54 - 60, Aug. 2018 , Refereed
  • Lysophosphatidic acid receptor-2 (LPA2) and LPA5 regulate cellular functions during tumor progression in fibrosarcoma HT1080 cells., Takahashi K, Minami K, Otagaki S, Ishimoto K, Fukushima K, Fukushima N, Honoki K, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, Aug. 2018 , Refereed
  • Induction of GPR40 positively regulates cell motile and growth activities in breast cancer MCF-7 cells., Fukushima K, Takahashi K, Kusaka M, Ishimoto K, Minami K, Otagaki S, Fukushima N, Honoki K, Tsujiuchi T, Journal of receptor and signal transduction research, Journal of receptor and signal transduction research, 1 - 5, Aug. 2018 , Refereed
  • Promotion of cell-invasive activity through the induction of LPA receptor-1 in pancreatic cancer cells., Fukushima K, Otagaki S, Takahashi K, Minami K, Ishimoto K, Fukushima N, Honoki K, Tsujiuchi T, Journal of receptor and signal transduction research, Journal of receptor and signal transduction research, 38(4), 367 - 371, Aug. 2018 , Refereed
  • Exposure to bisphenol A affects GABAergic neuron differentiation in neurosphere cultures., Fukushima N, Nagao T, Neuroreport, Neuroreport, 29(9), 712 - 717, Jun. 2018 , Refereed
  • Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs., Takahashi K, Fukushima K, Otagaki S, Ishimoto K, Minami K, Fukushima N, Honoki K, Tsujiuchi T, Journal of receptor and signal transduction research, Journal of receptor and signal transduction research, 38(1), 71 - 75, Feb. 2018 , Refereed
  • Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells., Fukushima K, Takahashi K, Kurokawa A, Ishimoto K, Otagaki S, Minami K, Fukushima N, Honoki K, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 496(1), 225 - 230, Jan. 2018 , Refereed
  • Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells, FUKUSHIMA Nobuyuki, 55, 1573 - 1583, Nov. 2016 , Refereed
  • Negative effects of G-protein- coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells., FUKUSHIMA Nobuyuki, 55, 1553 - 1559, Nov. 2016 , Refereed
  • Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13- acetate in melanoma cells., FUKUSHIMA Nobuyuki, 475, 25 - 30, Jul. 2016 , Refereed
  • Diverse effects of G-protein- coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells., FUKUSHIMA Nobuyuki, 342, 193 - 199, Mar. 2016 , Refereed
  • Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells., Fukushima K, Yamasaki E, Ishii S, Tomimatsu A, Takahashi K, Hirane M, Fukushima N, Honoki K, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, Aug. 2015 , Refereed
  • LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs., Mori S, Araki M, Ishii S, Hirane M, Fukushima K, Tomimatsu A, Takahashi K, Fukushima N, Tsujiuchi T, Molecular and cellular biochemistry, Molecular and cellular biochemistry, Jun. 2015 , Refereed
  • Comparative analyses of lysophosphatidic acid receptor-mediated signaling, FUKUSHIMA Nobuyuki, Cell. Mol. Life Sci., Cell. Mol. Life Sci., 72(12), 2377 - 2394, Jun. 2015 , Refereed
  • Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells., Ishii S, Hirane M, Fukushima K, Tomimatsu A, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 461(1), 59 - 64, May 2015 , Refereed
  • Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells., Ishii S, Hirane M, Kitamura Y, Mori S, Fukushima N, Honoki K, Tsujiuchi T, Molecular and cellular biochemistry, Molecular and cellular biochemistry, 400(1-2), 145 - 151, Feb. 2015 , Refereed
  • Expression of the long-chain fatty acid receptor GPR120 in the gonadotropes of the mouse anterior pituitary gland., Moriyama R, Deura C, Imoto S, Nose K, Fukushima N, Histochemistry and cell biology, Histochemistry and cell biology, 143(1), 21 - 27, Jan. 2015 , Refereed
  • Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells., Ishii S, Hirane M, Kato S, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 456(1), 135 - 138, Jan. 2015 , Refereed
  • Ethionine regulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells., Inoue S, Tanabe E, Shibata A, Hirane M, Araki M, Dong Y, Fukushima N, Tsujiuchi T, Molecular and cellular biochemistry, Molecular and cellular biochemistry, 383(1-2), 173 - 177, Nov. 2013 , Refereed
  • Inhibitory effects of LPA1 on cell motile activities stimulated by hydrogen peroxide and 2,3-dimethoxy-1,4-naphthoquinone in fibroblast 3T3 cells., Hirane M, Araki M, Dong Y, Honoki K, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 441(1), 47 - 52, Nov. 2013 , Refereed
  • Downregulation of activation factors of endothelia and fibroblasts via lysophosphatidic acid signaling in a mouse lung cancer LL/2 cell line., Tanabe E, Kitayoshi M, Hirane M, Araki M, Dong Y, Fukushima N, Tsujiuchi T, Journal of receptor and signal transduction research, Journal of receptor and signal transduction research, 33(5), 286 - 290, Oct. 2013 , Refereed
  • Extracellular lipid metabolism influences the survival of ovarian cancer cells., Kuwata S, Ohkubo K, Kumamoto S, Yamaguchi N, Izuka N, Murota K, Tsujiuchi T, Iwamori M, Fukushima N, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 439(2), 280 - 284, Sep. 2013 , Refereed
  • Extracellular lipid metabolism influences the survival of ovarian cancer cells, Biochem. Biophys. Res. Commun., Biochem. Biophys. Res. Commun., Aug. 2013
  • Lysophosphatidic acid receptor-3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells., Okabe K, Hayashi M, Kato K, Okumura M, Fukui R, Honoki K, Fukushima N, Tsujiuchi T, Molecular carcinogenesis, Molecular carcinogenesis, 52(4), 247 - 254, Apr. 2013 , Refereed
  • Hydrogen peroxide stimulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells., Shibata A, Tanabe E, Inoue S, Kitayoshi M, Okimoto S, Hirane M, Araki M, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 433(3), 317 - 321, Apr. 2013 , Refereed
  • Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cancer cells., Yoshikawa K, Tanabe E, Shibata A, Inoue S, Kitayoshi M, Okimoto S, Fukushima N, Tsujiuchi T, Experimental cell research, Experimental cell research, 319(3), 105 - 112, Feb. 2013 , Refereed
  • Negative regulation of cell motile and invasive activities by lysophosphatidic acid receptor-3 in colon cancer HCT116 cells., Fukui R, Tanabe E, Kitayoshi M, Yoshikawa K, Fukushima N, Tsujiuchi T, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 33(6), 1899 - 1905, Dec. 2012 , Refereed
  • Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells., Tanabe E, Kitayoshi M, Yoshikawa K, Shibata A, Honoki K, Fukushima N, Tsujiuchi T, Journal of receptor and signal transduction research, Journal of receptor and signal transduction research, 32(6), 328 - 334, Dec. 2012 , Refereed
  • Regulation of cell motile activity through the different induction of LPA receptors by estrogens in liver epithelial WB-F344 cells., Tanabe E, Shibata A, Inoue S, Kitayoshi M, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 428(1), 105 - 109, Nov. 2012 , Refereed
  • Opposite roles of LPA1 and LPA3 on cell motile and invasive activities of pancreatic cancer cells., Kato K, Yoshikawa K, Tanabe E, Kitayoshi M, Fukui R, Fukushima N, Tsujiuchi T, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 33(5), 1739 - 1744, Oct. 2012 , Refereed
  • Enhancement of Drug Resistance by Lysophosphatidic Acid Receptor-3 in Mouse Mammary Tumor FM3A Cells., Fukui R, Kato K, Okabe K, Kitayoshi M, Tanabe E, Fukushima N, Tsujiuchi T, Journal of toxicologic pathology, Journal of toxicologic pathology, 25(3), 225 - 228, Sep. 2012 , Refereed
  • Different effects on cell proliferation and migration abilities of endothelial cells by LPA₁ and LPA₃ in mammary tumor FM3A cells., Kitayoshi M, Fukui R, Tanabe E, Kato K, Yoshikawa K, Fukushima N, Tsujiuchi T, Journal of receptor and signal transduction research, Journal of receptor and signal transduction research, 32(4), 209 - 213, Aug. 2012 , Refereed
  • Enhancement of endothelial cell migration by constitutively active LPA(1)-expressing tumor cells., Kitayoshi M, Kato K, Tanabe E, Yoshikawa K, Fukui R, Fukushima N, Tsujiuchi T, BBRC, BBRC, 422(2), 339 - 343, Jun. 2012 , Refereed
  • Lysophosphatidic acid induces neurite branch formation through LPA3., FUKUSHIMA Nobuyuki, Mol. Cell. Neurosci., Mol. Cell. Neurosci., 50(1), 21 - 34, May 2012 , Refereed
  • Differential function of lysophosphatidic acid receptors in cell proliferation and migration of neuroblastoma cells., Hayashi M, Okabe K, Kato K, Okumura M, Fukui R, Fukushima N, Tsujiuchi T, Cancer Lett, Cancer Lett, 316(1), 91 - 96, Mar. 2012 , Refereed
  • Constitutively active lysophosphatidic acid receptor-1 enhances the induction of matrix metalloproteinase-2., Kato K, Fukui R, Okabe K, Tanabe E, Kitayoshi M, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 417(2), 790 - 793, Jan. 2012 , Refereed
  • Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide., Kurokawa Y, Sekiguchi F, Kubo S, Yamasaki Y, Matsuda S, Okamoto Y, Sekimoto T, Fukatsu A, Nishikawa H, Kume T, Fukushima N, Akaike A, Kawabata A, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 414(4), 727 - 732, Nov. 2011 , Refereed
  • Distinct DNA methylation patterns of lysophosphatidic acid receptor genes during rat hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet., Okabe K, Hayashi M, Yoshida I, Nishimura K, Fukushima N, Tsujiuchi T, Archives of toxicology, Archives of toxicology, 85(10), 1303 - 1310, Oct. 2011 , Refereed
  • Induction of lysophosphatidic acid receptor-3 by 12-O-tetradecanoylphorbol-13-acetate stimulates cell migration of rat liver cells., Okabe K, Kato K, Teranishi M, Okumura M, Fukui R, Mori T, Fukushima N, Tsujiuchi T, Cancer letters, Cancer letters, 309(2), 236 - 242, Oct. 2011 , Refereed
  • Genetic and epigenetic alterations of lysophosphatidic Acid receptor genes in rodent tumors by experimental models., Tsujiuchi T, Okabe K, Fukushima N, Journal of toxicologic pathology, Journal of toxicologic pathology, 24(3), 143 - 148, Sep. 2011 , Refereed
  • No Involvement of Lysophosphatidic Acid Receptor-3 in Cell Migration of Mouse Lung Tumor Cells Stimulatedby 12-O-Tetradecanoylphorbol-13-acetate., Okumura M, Kato K, Fukui R, Fukushima N, Tsujiuchi T, Journal of toxicologic pathology, Journal of toxicologic pathology, 24(3), 183 - 186, Sep. 2011 , Refereed
  • Possible involvement of lysophosphatidic acid receptor-5 gene in the acquisition of growth advantage of rat tumor cells., Okabe K, Hayashi M, Yamawaki Y, Teranishi M, Honoki K, Mori T, Fukushima N, Tsujiuchi T, Molecular carcinogenesis, Molecular carcinogenesis, 50(8), 635 - 642, Aug. 2011 , Refereed
  • Coordinated interactions between actin and microtubules through crosslinkers in neurite retraction induced by lysophosphatidic acid., Fukushima N, Furuta D, Tsujiuchi T, Neurochemistry international, Neurochemistry international, 59(2), 109 - 113, Aug. 2011 , Refereed
  • Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells., Hayashi M, Okabe K, Yamawaki Y, Teranishi M, Honoki K, Mori T, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 405(3), 450 - 454, Feb. 2011 , Refereed
  • Mutations of lysophosphatidic Acid receptor genes in human osteosarcoma cells., Okabe K, Hayashi M, Fujii M, Honoki K, Mori T, Fukushima N, Tsujiuchi T, Pathobiology, Pathobiology, 77(5), 278 - 282, Dec. 2010 , Refereed
  • Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells., Tsujino M, Fujii M, Okabe K, Mori T, Fukushima N, Tsujiuchi T, Virchows Archiv : an international journal of pathology, Virchows Archiv : an international journal of pathology, 457(6), 669 - 676, Dec. 2010 , Refereed
  • Lysophosphatidic acid influences initial neuronal polarity establishment., Yamane M, Furuta D, Fukushima N, Neuroscience letters, Neuroscience letters, 480(2), 154 - 157, Aug. 2010 , Refereed
  • Different expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in mouse tumor cells., Okabe K, Hayashi M, Wakabayashi N, Yamawaki Y, Teranishi M, Fukushima N, Tsujiuchi T, Pathobiology : journal of immunopathology, molecular and cellular biology, Pathobiology : journal of immunopathology, molecular and cellular biology, 77(6), 309 - 314, 2010 , Refereed
  • Posttranslational modifications of tubulin in the nervous system., Fukushima N, Furuta D, Hidaka Y, Moriyama R, Tsujiuchi T, J. Neurochem., J. Neurochem., 109(3), 683 - 693, May 2009 , Refereed
  • Infrequent mutation of lysophosphatidic Acid receptor-1 gene in hamster pancreatic duct adenocarcinomas and established cell lines., Tsujiuchi T, Furukawa M, Obo Y, Yamasaki A, Hotta M, Kusunoki C, Suyama N, Mori T, Honoki K, Fukushima N, Journal of toxicologic pathology, Journal of toxicologic pathology, 22(1), 89 - 92, Mar. 2009 , Refereed
  • Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors., Obo Y, Yamada T, Furukawa M, Hotta M, Honoki K, Fukushima N, Tsujiuchi T, Mutation research, Mutation research, 660(1-2), 47 - 50, Jan. 2009 , Refereed
  • Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats., Yamada T, Obo Y, Furukawa M, Hotta M, Yamasaki A, Honoki K, Fukushima N, Tsujiuchi T, Biochemical and biophysical research communications, Biochemical and biophysical research communications, 378(3), 424 - 427, Jan. 2009 , Refereed
  • A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation., Biochimica et Biophysica Acta Mol. Cell Res., Biochimica et Biophysica Acta Mol. Cell Res., 1783, 748 - 759, May 2008
  • Lysophosphatidic acid stimulates astrocyte proliferation through LPA1., Neurochem. Int., Neurochem. Int., 52, 216 - 220, Jan. 2008
  • Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-Gi/o pathway., Neurochem. Intl., Neurochem. Intl., 50, 302 - 307, Jan. 2007
  • Actomyosin-dependent microtubule rearrangement in lysophosphatidic acid-induced neurite remodeling of young cortical neurons., Brain Res., Brain Res., 1094, 65 - 75, Jun. 2006
  • Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2)., Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J, Molecular and cellular biology, Molecular and cellular biology, 22(19), 6921 - 6929, Oct. 2002 , Refereed
  • Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rho., Fukushima N, Ishii I, Habara Y, Allen CB, Chun J, Molecular biology of the cell, Molecular biology of the cell, 13(8), 2692 - 2705, Aug. 2002 , Refereed
  • Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons., Fukushima N, Weiner JA, Kaushal D, Contos JJ, Rehen SK, Kingsbury MA, Kim KY, Chun J, Molecular and cellular neurosciences, Molecular and cellular neurosciences, 20(2), 271 - 282, Jun. 2002 , Refereed

Books etc

  • Lysophosphatidic acid receptor. Encyclopedia of SIgnaling Molecules,, Fukushima, N, Kado T, Tsujiuchi, T, Springer,   2017
  • Neural effects of LPA signaling. In Lysophospholipid Receptors: Signaling and Biochemistry., FUKUSHIMA Nobuyuki, 単著, Wiley,   2013
  • Cytoskeleton of the Nervous System, Advances in Neurobiology, Microtubules in the Nervous System., Fukushima, N, 単著, Springer,   2011

Conference Activities & Talks

  • Molecular mechanism of LPA3-mediated axonal branching formation in cultured hippocampal neurons,   2010 12
  • Lysophosphatidic acid receptor 3 activation induces axonal branch formation in cultured hippocampal neurons,   2010 09
  • Palmitate regulates GnRH receptor mRNA expression level in the gonadotrope of the mouse anterior pituitary gland., 14th International Congress of Endocrinology,   2010 03 , 14th International Congress of Endocrinology
  • Lysophosphatidic acid receptor 3 is involved in neurite branching formation in hippocampal neurons,   2009 10
  • LPA induces neurite shape changes through LPA3, PLM2009,   2009 05 , PLM2009
  • Regulation of neurite morphology by LPA, PLM2009,   2009 05 , PLM2009
  • Palmitate regulates GnRH receptor mRNA expression level in the gonadotrope of the mouse pituitary gland.,   2009 05
  • Palmitate regulates GnRH receptor mRNA expression in the gonadotrope of the mouse anterior pituitary,   2008 07
  • Fasting induced increase in long-chain fatty acid receptor GPR120 expression in the gonadotrope of the mouse anterior pituitary., 37th Annual Meeting of Society for Neuroscience,   2007 11 , 37th Annual Meeting of Society for Neuroscience
  • Palmitate-induced increase in long-chain fatty acid receptor GPR120 mRNA level in LβT2 pituitary gonadotrope cells.,   2007 09
  • Fasting induced Long-chain fatty acid receptor GPR120 expression increase in the anterior pituitary of mouse.,   2006 07