KINDAI UNIVERSITY


*A space between the first name and last name, please enter

HACHIKEN Hiroko

Profile

FacultyDepartment of Pharmacy
PositionAssistant Professor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/817-hachiken-hiroko.html
URL
Mail
Last Updated :2020/08/10

Education and Career

Education

  •  - 1984 , Kindai University, Faculty of Pharmacy
  •  - 1984 , Kinki University, Faculty of Pharmaceutical Science

Research Activities

Research Areas

  • Life sciences, Clinical pharmacy

Published Papers

  • The usefulness of self-evaluation rubric table as a component of a learning, MATZNO S, HACHIKEN H, 薬学教育, 薬学教育, 2, 2018 , Refereed
  • Synthesis of ellipticine by reaction of 1-(4-methoxybenzyl)indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitanium, Y Miki, H Hachiken, N Yanase, JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001(18), 2213 - 2216, Sep. 2001 , Refereed
    Summary:Reaction of 1-benzyl- and 1-(4-methoxybenzyl)indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium gave the corresponding 2-acylindole-3-carboxylic acids as-the sole product. Deprotection of the 1-(4-methoxybenzyl) group of the 2-acylindole-3-carboxylic acid was performed by treatment with perchloric acid in acetic acid to afford 2-(3-bromoisonicotinoyl)indole, which was converted to ellipticine.
  • REACTION OF CHALCONE WITH PHENYLIODINE(III) BIS(TRIFLUOROACETATE) (PIFA) - SYNTHESIS OF +/--HOMOPTEROCARPIN, Y MIKI, S KOBAYASHI, N OGAWA, H HACHIKEN, SYNLETT, SYNLETT, (12), 1001 - 1002, Dec. 1994 , Refereed
    Summary:Treatment of 1,3-bis(2'-benzyloxy-4'-methoxyphenyl)-propen-1-one with phenyliodine(III) bis(trifluoroacetate) gave a rearrangement product, 1,2-bis(2'-benzyloxy-4'-methoxyphenyl)-3,3-dimethoxypropan-1-one, which was converted into (+/-)-homopterocarpin.
  • SYNTHESIS AND DIELS-ALDER REACTION OF 4-BENZYL-1-TERT-BUTYLDIMETHYLSILOXY-4H-FURO[3,4-B]INDOLE - SYNTHESIS OF MURRAYAQUINONE-A, Y MIKI, H HACHIKEN, SYNLETT, SYNLETT, (5), 333 - 334, May 1993
    Summary:4-Benzyl-1-tert-butyldimethylsiloxy-4H-furo[3,4-b]indole (2) was synthesized by selective reduction of 1-benzylindole-2,3-dicarboxylic anhydride with sodium borohydride, followed by treatment of the resulting lactone with base and tert-butyldimethylsilyl chloride. Diels-Alder reaction of the furoindole (2) with methyl acrylate and then treatment of die resulting adduct with boron trifluoride etherate gave methyl 9-benzyl-4-hydroxycarbazole-3-carboxylate in a regioselective manner, which was converted to murrayaquinone-A.
  • ACID-CATALYZED REACTIONS OF 1(ALPHA-HYDROXYBENZYL)INDOLIZINES AND 3-(ALPHA-HYDROXYBENZYL)INDOLIZINES, Y MIKI, Y HIROISHI, H HACHIKEN, S TAKEMURA, JOURNAL OF HETEROCYCLIC CHEMISTRY, JOURNAL OF HETEROCYCLIC CHEMISTRY, 28(1), 45 - 48, Jan. 1991 , Refereed
    Summary:Treatment of 1-(alpha-hydroxybenzyl)- and 3-(alpha-hydroxybenzyl)indolizines with trifluoroacetic acid in dichloromethane gave phenylbis(alpha-indolizinyl)methanes, bis[alpha-(indolizinyl)benzyl] ethers and indolizines, depending upon the presence or absence of the substituent at the 2- or 5-position and the reaction conditions used.
  • EFFECT OF 3,3'-DIHYDROXY-ALPHA,BETA-DIETHYLDIPHENYLETHANE ON CORONARY AND MESENTERIC-ARTERIES ISOLATED FROM GUINEA-PIGS, Y INAMORI, H TSUJIBO, H HACHIKEN, Y MIKI, S TAKEMURA, CHEMICAL & PHARMACEUTICAL BULLETIN, CHEMICAL & PHARMACEUTICAL BULLETIN, 36(3), 1252 - 1255, Mar. 1988 , Refereed
  • ACID-CATALYZED REACTIONS OF 3-(ALPHA-HYDROXYBENZYL)PYRAZOLO[1,5-A]PYRIDINES, Y MIKI, O TOMII, H NAKAO, M KUBO, H HACHIKEN, S TAKEMURA, M IKEDA, JOURNAL OF HETEROCYCLIC CHEMISTRY, JOURNAL OF HETEROCYCLIC CHEMISTRY, 25(1), 327 - 331, Jan. 1988 , Refereed
  • Synthesis of 2-and 3-benzoylindoles by Friedel-Crafts reaction of indole-2,3-dicarboxylic anhydrides with anisoles, Y Miki, Y Tsuzaki, C Kai, H Hachiken, HETEROCYCLES, HETEROCYCLES, 57(9), 1635 - 1643, Sep. 2002 , Refereed
    Summary:Reaction of 1-benzylindole-2,3-dicarboxylic anhydride with anisole in the presence of titanium(IV) chloride gave 2-(4-methoxybenzoyl)indole-3-carboxylic acid as the sole product. However, 1-benzenesulfonylindole-2,3-dicarboxylic anhydride with anisole afforded 3-(4-methoxybenzoyl)indole-2-carboxylic acid. These carboxylic acids could be converted to the corresponding benzoylindoles.
  • Reaction of 1-benzenesulfonylindole-2,3-dicarboxylic anhydride with wittig reagents: Synthesis of pyrrolo[1,2-a]-indoles and cyclopent[b]indole, Y Miki, H Hachiken, A Kawazoe, Y Tsuzaki, N Yanase, HETEROCYCLES, HETEROCYCLES, 55(7), 1291 - +, Jul. 2001 , Refereed
    Summary:Treatment of 1-benzenesulfonylindole-2,3-dicarboxylic anhydride with methylenetriphenylphosphorane gave the corresponding ylide. After esterification of the carboxyl group and removal of the benzenesulfonyl group of the ylide, the obtained ylide was reacted with aldehydes to yield alpha,beta -unsaturated ketones, which were converted to pyrrolo[1,2-a]indoles. We also examined the reactivity of the anhydride with (carbethoxymethylene)triphenylphosphorane and (carbethoxyethylidene)triphenylphosphorane.
  • Reaction of 3-ethoxycarbonylindolizine-1,2-dicarboxylic anhydride: Synthesis of 2-acylindolizines and quinones, Y Miki, N Nakamura, R Yamakawa, H Hachiken, K Matsushita, HETEROCYCLES, HETEROCYCLES, 53(10), 2143 - +, Oct. 2000 , Refereed
    Summary:Reaction of indolizine-1,2-dicarboxylic anhydride with Grignard reagents gave 2-acylindolizine-1-carboxylic acids, which were converted to 2-acylindolizines. The anhydride reacted with anisole in the presence of titanium chloride(IV) to afford 2-(4-methoxybenzoyl)indolizine-1-carboxylic acid, which was also led to 2-(4-methoxybenzoyl)indolizine. Successive treatment of the 2-acylindolizine-1-carboxylic acids with phosphorus pentachloride and aluminum(III) chloride provided the corresponding quinones.
  • Reaction of 3-ethoxycarbonylindolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitaniuim: Synthesis of 5,12-dimethylindolizino[2,1-g]isoquinoline (ellipticine analogue), Y Miki, N Nakamura, R Yamakawa, H Hibino, H Hachiken, K Matsushita, HETEROCYCLES, HETEROCYCLES, 53(10), 2123 - +, Oct. 2000 , Refereed
    Summary:Reaction of indolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium gave 2-(3-bromoisonicotinoyl)-3-ethoxycarbonyl-indolizine-1-carboxylic acid as the sole product. The indolizine-l-carboxylic acid could be converted to 5,12-dimethylindolizine[2,1-g] isoquinoline in six steps.
  • Biological activity of alkyl 2-(acylthio)benzoates, E Matsumura, T Nishinaka, H Tsujibo, H Hachiken, Y Miki, Y Sakagami, Y Inamori, BIOLOGICAL & PHARMACEUTICAL BULLETIN, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 23(2), 254 - 256, Feb. 2000 , Refereed
    Summary:Of a series of synthetic alkyl 2-(acylthio)benzoate (1-20), all the derivatives except for n-butyl 2-butyrylthiobenzoate (18) and n-butyl 2-n-valerylthiobenzoate (20) showed clear photogrowth-inhibitory activity. All the compounds tested except for methyl 2-butyrylthiobenzoate (3) exhibited cytotoxic activity on mouse splenic T cells, Strong phytogrowth-inhibition and cytotoxic activity were found with 1, 6, 11 and 16 with an acetylthio group at C-2, suggesting that the acetyl group seems to play an important role in both activities of alkyl 2-(acylthio)benzoates. Among them, methyl 2-acetylthiobenzoate (1) was the strongest inhibitor. On the other hand, potent inhibition of prolyl endopeptidase was exhibited by 2, 7, 12 and 17 with a propionylthio group at C-2. These findings imply that a propionyl group might be useful for increasing the inhibitory activity against on prolyl endopeptidase.
  • p-methoxybenzyl group as a protecting group of the nitrogen in indole derivatives: Deprotection by DDQ or trifluoroacetic acid, Y Miki, H Hachiken, Y Kashima, W Sugimura, N Yanase, HETEROCYCLES, HETEROCYCLES, 48(1), 1 - 4, Jan. 1998 , Refereed
    Summary:Deprotection of 9-p-methoxybenzylcarbazole with DDQ gave a carbazole. However, methyl 1-p-methoxybenzylindole-2-carboxylate and dimethyl 1-p-methoxybenzyl-2,3-indoledicarboxylate were treated with TFA to yield the corresponding methyl indole-2-carboxylate and dimethyl indole-2,3-dicarboxylate.
  • Reaction of 1-benzylindole-2,3-dicarboxylic anhydride with Wittig reagents, Y Miki, H Hachiken, Y Sugimoto, N Yanase, HETEROCYCLES, HETEROCYCLES, 45(9), 1759 - 1766, Sep. 1997 , Refereed
    Summary:Reaction of 1-benzylindole-2,3-dicarboxylic anhydride with methylenetriphenylphosphorane (Ph3P=CH2) and carbethoxymethylenetriphenylphosphorane (Ph3P=CHCOOEt) gave [2-(3-carboxyindol-2-yl)-2-oxoethylidene]triphenylphosphorane derivatives, which were converted to cyclopenta[b]indol-3-ones after decarboxylation and treatment with aldehydes. On the other hand, the anhydride reacted with carbethoxyethylidenetriphenylphosphorane (Ph3P=C(Me)COOEt) to afford a mixture of two enol lactones.
  • Reaction of indole-2,3-dicarboxylic anhydride with Grignard reagents: Synthesis of 2-acylindoles, Y Miki, H Hachiken, Yoshikawa, I, HETEROCYCLES, HETEROCYCLES, 45(6), 1143 - 1150, Jun. 1997 , Refereed
    Summary:Reaction of indole-2,3-dicarboxylic anhydride with methylmagnesium bromide and phenylmagnesium bromide gave 2-acetyl- and 2-benzoyl-indole-3-carboxylic acids, but with tert-butylmagnesium chloride, 3-pivaloylindole-2-carboxylic acids were obtained as the main products. Treatment of 2-acylindole-3-carboxylic acids with copper chromite in quinoline or potassium hydroxide gave the corresponding 2-acylindoles.
  • Reaction of indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium: Synthesis of ellipticine, Y Miki, Y Tada, N Yanase, H Hachiken, K Matsushita, TETRAHEDRON LETTERS, TETRAHEDRON LETTERS, 37(43), 7753 - 7754, Oct. 1996
    Summary:N-Benzylindole-2,3-dicarboxylic anhydride (1) was reacted with (3-bromo-4-pyridyl)triisopropoxytitanium to give 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid (2) as the sole product in high yield, which could be converted to ellipticine in six steps. Copyright (C) 1996 Elsevier Science Ltd
  • SYNTHESIS OF 3-SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINES BY ELECTROPHILIC REACTIONS, Y MIKI, S YAGI, H HACHIKEN, M IKEDA, HETEROCYCLES, HETEROCYCLES, 38(8), 1881 - 1887, Aug. 1994 , Refereed
    Summary:Reactions of pyrazolo[1,5-a]pyridines with Eschenmoser's salt, activated alkenes and alkynes, and chlorosulfonyl isocyanate provided general routes to 3-substituted pyrazolo[1,5-a]pyridines such as 3-dimethylaminomethyl- and 3-(2-nitroethyl)pyrazolo[ 1,5-a]pyridines, 1-phenyl-3-(pyrazolo[1,5-a]pyrid-3-yl)-2-propen-1-ones, 4-(pyrazolo[1,5-a]pyrid-3-yl)-3-buten-2-one, pyrazolo[1,5-a]pyridine-3-carboxamide, and pyrazolo[1,5-a]pyridine-3-carbonitrile.
  • SYNTHESIS OF METHYL AND ETHYL 3-ALKYLTHIAZOLIDINE-4(R)-CARBOXYLATES AND THEIR ROOTS INHIBITION OF THE GROWTH OF BRASSICA-CAMPESTRIS, Y INAMORI, C MURO, H YAMANAKA, K OSAKA, H HACHIKEN, H TSUJIBO, Y MIKI, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 58(6), 1150 - 1152, Jun. 1994 , Refereed
    Summary:Methyl and ethyl 3-alkylthiazolidine-4(R)-carboxylates (1-6 and 7-12), which were newly synthesized, inhibited growth of the roots of Brassica campestris L. subsp. rapa HOOK fil. et ANDERS. Of the methyl esters, methyl 3-methylthiazolidine-4(R)-carboxylate (2) was the strongest inhibitor. Of the ethyl esters, ethyl 3-methylthiazolidine-4(R)-carboxylate (8) was the strongest inhibitor. The chlorophyll concentration in the cotyledons of plants treated with any of the compounds, except for 7, was decreased.
  • ACID-CATALYZED REACTION OF PYRAZOLO[1,5-A]PYRIDINES WITH ALDEHYDES - FORMATION OF BIS(PYRAZOLO[1,5-A]PYRID-3-YL)METHANES, Y MIKI, S YAGI, H HACHIKEN, M IKEDA, JOURNAL OF HETEROCYCLIC CHEMISTRY, JOURNAL OF HETEROCYCLIC CHEMISTRY, 30(4), 1045 - 1046, Jul. 1993 , Refereed
    Summary:Reaction of pyrazolo[1,5-a]pyridines with aldehydes in the presence of trifluoroacetic acid gave bis(pyrazolo[1,5-a]pyrid-3-yl)methanes in high yields.
  • A NEW ENTRY TO [2.3.4]CYCLAZINES, Y MIKI, H HACHIKEN, M YOSHIKAWA, S TAKEMURA, M IKEDA, HETEROCYCLES, HETEROCYCLES, 32(4), 655 - 658, Apr. 1991 , Refereed
    Summary:Treatment of 2,3-dihydro-2-methyl-3-phenyl-1H-pyrazino[3,4,5-cd]indolizine 2-oxides (5) with trifluoroacetic anhydride gave new heterocyclic six-membered betaines (6) which underwent 1,3-dipolar cycloaddition reaction with dimethyl acetylenedicarboxylate and maleimides in hot toluene to yield the corresponding cycloadducts (7) and (8). Treatment of the maleimide adducts (8) with p-toluenesulfonic acid in boiling acetic acid gave the [2.3.4]cyclazines (9).
  • SYNTHESIS AND BIOACTIVITY OF PROPRANOLOL ANALOGS WITH A RIGID SKELETON .1., Y MIKI, H HACHIKEN, K NOGUCHI, M OHTA, A NAKANO, K TAKAHASHI, S TAKEMURA, CHEMICAL & PHARMACEUTICAL BULLETIN, CHEMICAL & PHARMACEUTICAL BULLETIN, 38(12), 3257 - 3260, Dec. 1990 , Refereed
    Summary:The synthesis of two kinds of propranolol analogues, A and B, with a rigid skeleton was investigated. The compounds were designed to help identify the conformation involved in beta-adrenergic receptor-propranolol interaction.1) The key intermediate, 2-hydroxy.2,3-dihydronaphtho[1,8-bc]pyran (5), was obtained starting from acenaphthenone (1). On sequential dehydration, hydroboration, and oxidation, 5 gave 2,3-dihydronaphtho[1,8-bc]pyran-3-one (8), which was converted to compound A. Compound 5 was also derived to 2-formyl-2,3-dihydronaphthol[1,8-bc]pyran (13) via the 2-vinyl compound (12). Condensation of nitromethane with 13 followed by reduction and alkylation produced the desired compound B. The beta-blocking activities of A and B were examined.
  • A SIMPLE SYNTHESIS OF NAPHTHO[1,8-BC]PYRAN, Y MIKI, M OHTA, H HACHIKEN, S TAKEMURA, SYNTHESIS-STUTTGART, SYNTHESIS-STUTTGART, (4), 312 - 312, Apr. 1990 , Refereed
  • ACID-CATALYZED REACTIONS OF 3-(HYDROXYMETHYL)PYRAZOLO[1,5-A]PYRIDINE AND 3-(1-HYDROXYETHYL)PYRAZOLO[1,5-A]PYRIDINE, Y MIKI, N NAKAMURA, H HACHIKEN, S TAKEMURA, JOURNAL OF HETEROCYCLIC CHEMISTRY, JOURNAL OF HETEROCYCLIC CHEMISTRY, 26(6), 1739 - 1745, Nov. 1989 , Refereed
  • NOVEL SYNTHESIS AND 1,3-DIPOLAR CYCLOADDITION REACTION OF PYRIDINIUM N-METHYLIDE, Y MIKI, H HACHIKEN, S TAKEMURA, M IKEDA, HETEROCYCLES, HETEROCYCLES, 22(4), 701 - 703, 1984 , Refereed

Conference Activities & Talks

  • Difference between the frequencies of antisecretory drug prescriptions in users of buffered versus enteric-coated low-dose aspirin therapies., HACHIKEN Hiroko, Hiroko Hachiken, Ai Murai, Kyoichi Wada, Takeshi Kuwahara, Kouichi Hosomi and Mitsutaka Takada.,   2013 10
  • Analysis of the questionnaire survey on the continuing education seminar 2010 at Kinki University Faculty of Pharmacy,   2011 03
  • Quantitative analysis of Japanese journal articles on medical pharmacy, 16th JSPE and 5th ACPE joint meeting,   2010 10 , 16th JSPE and 5th ACPE joint meeting
  • Trend Analysis of Japanese Journal Articles on Medical Pharmacy Using Text Mining,   2010 07
  • The Implementation of the Model Core Curriculum toward Hospital Pharmacy Practice Experience,   2009 03
  • The Implementation of the Model Core Curriculum toward Pharmacy Practice Experience for 2-4 weeks,   2008 03
  • A Survey on the Students’ Attitudes toward Pharmacy Practice Experience in Kinki University,   2007 03

Misc

  • テキストマイニング手法による医療薬学研究トレンド解析, 後藤佐昌子, 八軒浩子, 細見光一, 北小路学, 高田充隆, 医療薬学フォーラム講演要旨集, 18th, 131,   2010 07 , https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201002285838274193
  • NEW SYNTHESIS OF CYCL[4.3.2]AZINES, Y MIKI, H HACHIKEN, M YOSHIKAWA, A NAKANO, S TAKEMURA, JOURNAL OF PHARMACEUTICAL SCIENCES, 76, 11, S142, S142,   1987 11

Research Grants & Projects

  • Study on Synthesis of Indole Alkaloides