KINDAI UNIVERSITY


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TSUJIUCHI Toshifumi

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FacultyDepartment of Life Science / Graduate School of Science and Engineering Research
PositionProfessor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/754-tsujiuchi-toshifumi.html
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Mail
Last Updated :2020/04/08

Education and Career

Education

  •  - 1992 , Nara Medical University
  •  - 1992 , Nara Medical University, Graduate School, Division of Medicine

Research Activities

Research Areas

  • Life sciences, Experimental pathology
  • Life sciences, Human pathology

Published Papers

  • Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs, Minami K, Ueda N, Ishimoto K, Tsujiuchi T., MOLECULAR AND CELLULAR BIOCHEMISTRY, MOLECULAR AND CELLULAR BIOCHEMISTRY, 2020 , Refereed
  • Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells., Ueda N, Minami K, Ishimoto K, Tsujiuchi T., Cellular Signalling, Cellular Signalling, 2020 , Refereed
  • Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells., Minami K, Ueda N, Ishimoto K, Tsujiuchi T., J Recept Signal Transduct Res., J Recept Signal Transduct Res., 40(2), 181 - 186, 2020 , Refereed
  • LPA5-mediated signaling induced by endothelial cells and anticancer drug regulates cellular functions of osteosarcoma cells, Minami K, Ueda N, Ishimoto K, Tsujiuchi T, Exp Cell Res., Exp Cell Res., 2020 , Refereed
  • Modulation of chemoresistance by lysophosphatidic acid (LPA) signaling through LPA5 in melanoma cells treated with anticancer drugs, Minami K, Ueda N, Maeda H, Ishimoto K, Otagaki S, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 517, 359 - 363, 2019 , Refereed
  • Rapid establishment of highly migratory cells from cancer cells for investigating cellular functions, Ishimoto K, Minami K, Otagaki S, Tsujiuchi T, J Recept Signal Transduct Res, J Recept Signal Transduct Res, (39), 194 - 198, 2019 , Refereed
  • Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells, Takahashi K, Fukushima K, Tanaka K, Minami K, Ishimoto K, Otagaki S, Fukushima N, Honoki K, Tsujiuchi T, Exp Cell Res, Exp Cell Res, 369(2), 316 - 324, Aug. 2018 , Refereed
  • Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells., Fukushima K, Takahashi K, Kurokawa A, Ishimoto K, Otagaki S, Minami K, Fukushima N, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 496, 225 - 230, 2018 , Refereed
  • Promotion of cell invasive activity through the induction of LPA receptor-1 in pancreatic cancer cells., Fukushima K, Otagaki S, Takahashi K, Minami K, Ishimoto K, Fukushima N, Honoki K, Tsujiuchi T, J Recept Signal Transduct Res., J Recept Signal Transduct Res., 38(4), 367 - 371, 2018 , Refereed
  • Lysophosphatidic acid receptor-2 (LPA2) and LPA5 regulate cellular functions during tumor progression in fibrosarcoma HT1080 cells., Takahashi K, Minami K, Otagaki S, Ishimoto K, Fukushima K, Fukushima N, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 503, 2698 - 2703, 2018 , Refereed
  • Induction of GPR40 positively regulates cell motile and growth activities in breast cancer MCF-7 cells, Fukushima K, Takahashi K, Kusaka M, Ishimoto K, Otagaki S, Minami K, Fukushima N, Honoki K, Tsujiuchi T, J Recept Signal Transduct Res, J Recept Signal Transduct Res, 38(4), 311 - 315, 2018 , Refereed
  • Involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells., Takahashi K, Fukushima K, Onishi Y, Minami K, Otagaki S, Ishimoto K, Fukushima N, Honoki K, Tsujiuchi T, Exp Cell Res, Exp Cell Res, 369, 54 - 60, 2018 , Refereed
  • Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs., Takahashi K, Fukushima K, Otagaki S, Ishimoto K, Minami K, Fukushima N, Honoki K, Tsujiuchi T, J Recept Signal Transduct Res., J Recept Signal Transduct Res., 38, 71 - 75, 2018 , Refereed
  • Crossroads of hallmarks in aging and cancer: Anti-aging and anti-cancer target pathways can be shared?, Honoki K, Kuniyasu H, Kishi S, Tanaka Y, Tsujiuchi T, Trends Cancer Res, Trends Cancer Res, 11, 41 - 59, 2016 , Refereed
  • Different effects of GPR120 and GPR40 on cellular functions stumulated by 12-O-tetradecanoylphorbor-13 acetate in melanoma cells., Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 475, 25 - 30, 2016 , Refereed
  • Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells., Kita T, Kadochi Y, Takahashi K, Fukushima K, Yamasaki E, Uemoto T, Hirane M, Fukushima N, Honoki K, Tsujiuchi T, Exp Cell Res, Exp Cell Res, 342, 193 - 199, 2016 , Refereed
  • Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells., Ishii S, Kitamura Y, Hirane M, Tomimatsu A, Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 55, 1553 - 1559, 2016 , Refereed
  • Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells., Hirane M, Ishii S, Tomimatsu A, Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 55, 1573 - 1583, 2016 , Refereed
  • Comparative analyses of lysophosphatidic acid receptor-mediated signaling, Fukushima N, Ishii S, Tsujiuchi T, Kagawa N, Katoh K, Cellular and Molecular Life Sciences, Cellular and Molecular Life Sciences, 72(12), 2377 - 2394, 2015 , Refereed
  • Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells., Ishii S, Hirane M, Kato S, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 456, 135 - 138, 2015 , Refereed
  • Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells., Ishii S, Hirane M, Kitamura Y, Mori S, Fukushima N, Honoki K, Tsujiuchi T, Mol Cell Biochem, Mol Cell Biochem, 400, 145 - 151, 2015 , Refereed
  • Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells., Ishii S, Hirane M, Fukushima K, Tomimatsu A, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 461, 59 - 64, 2015 , Refereed
  • Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells., Fukushima K, Yamasaki E, Ishii S, Tomimatsu A, Takahashi K, Hirane M, Fukushima N, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 465, 512 - 515, 2015 , Refereed
  • LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs., Mori S, Araki M, Ishii S, Hirane M, Fukushima K, Tomimatsu A, Takahashi K, Fukushima N, Tsujiuchi T, Mol Cell Biochem, Mol Cell Biochem, 408, 147 - 154, 2015 , Refereed
  • Diverse effects of LPA receptors on cell motile activities of cancer cells., Tsujiuchi T, Hirane M, Dong Y, Fukushima N, J Recept Signal Transduct Res, J Recept Signal Transduct Res, 34, 201 - 204, 2014 , Refereed
  • Extracellular lipid metabolism influences the survival of ovarian cancer cells, Kuwata S, Ohkubo K, Kumamoto S, Yamaguchi N, Izuka N, Murota K, Tsujiuchi T, Iwamori M, Fukushima N, Biochem. Biophys. Res. Commun., Biochem. Biophys. Res. Commun., Aug. 2013 , Refereed
  • Downregulation of activation factors of endothelia and fibroblasts via lysophosphatidic acid signaling in a mouse lung cancer LL/2 cell line., Tanabe E, Kitayoshi M, Hirane M, Araki M, Dong Y, Fukushima N, Tsujiuchi T, J Recept Signal Transduct Res, J Recept Signal Transduct Res, 33, 286 - 290, 2013 , Refereed
  • Ethionine regulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells., Inoue S, Tanabe E, Shibata A, Hirane M, Araki M, Dong Y, Fukushima N, Tsujiuchi T, Mol Cell Biochem, Mol Cell Biochem, 383, 173 - 177, 2013 , Refereed
  • Hydrogen peroxide stimulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells., Shibata A, Tanabe E, Inoue S, Kitayoshi M, Okimoto S, Hirane M, Araki M, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 433, 317 - 321, 2013 , Refereed
  • Inhibitory effects of LPA1 on cell motile activities stimulated by hydrogen peroxide and 2,3-dimethoxy-1,4-naphthoquinone in fibroblast 3T3 cells., Hirane M, Araki M, Dong Y, Honoki K, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 441, 47 - 52, 2013 , Refereed
  • Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cancer cells., Yoshikawa K, Tanabe E, Shibata A, Inoue S, Kitayoshi M, Okimoto S, Fukushima N, Tsujiuchi T, Exp Cell Res, Exp Cell Res, 319, 105 - 109, 2013 , Refereed
  • Lysophosphatidic acid receptor-3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells., Okabe K, Hayashi M, Kato K, Okumura M, Fukui R, Honoki K, Fukushima N, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 50, 247 - 254, 2013 , Refereed
  • Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice., Matsunami M, Miki T, Nishiura K, Hayashi Y, Okawa Y, Nishikawa H, Sekiguchi F, Kubo L, Ozaki T, Tsujiuchi T, Kawabata A, British journal of pharmacology, British journal of pharmacology, 167(4), 917 - 928, Oct. 2012 , Refereed
  • Enhancement of Drug Resistance by Lysophosphatidic Acid Receptor-3 in Mouse Mammary Tumor FM3A Cells., Fukui R, Kato K, Okabe K, Kitayoshi M, Tanabe E, Fukushima N, Tsujiuchi T, Journal of toxicologic pathology, Journal of toxicologic pathology, 25(3), 225 - 228, Sep. 2012 , Refereed
  • Enhancement of endothelial cell migration by constitutively active LPA(1)-expressing tumor cells., Kitayoshi M, Kato K, Tanabe E, Yoshikawa K, Fukui R, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun, Biochem Biophys Res Commun, 422, 339 - 343, Jun. 2012 , Refereed
  • Lysophosphatidic acid induces neurite branch formation through LPA3., Furuta D, Yamane M, Tsujiuchi T, Moriyama R, Fukushima N, Mol Cell Neurosci, Mol Cell Neurosci, 50, 21 - 34, May 2012 , Refereed
  • Different function of lysophosphatidic acid receptors in cell proliferation and migration of neuroblastoma cells., Hayashi M, Okabe K, Kato K, Okumura M, Fukui R, Fukushima N, Tsujiuchi T, Cancer Lett, Cancer Lett, 316, 9196 - 96, Mar. 2012 , Refereed
  • Constitutively active lysophosphatidic acid receptor-1 enhances the induction of matrix metalloproteinase-2., Kato K, Fukui R, Okabe K, Tanabe E, Kitayoshi M, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 417, 790 - 793, Feb. 2012 , Refereed
  • Ingestion of proteoglycan fraction from shark cartilage increased serum inhibitory activity against matrix metalloproteinase-9 and suppresses development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic duct adenocarcinogenesis in hamster., Kitahashi T, Ikawa S, Sakamoto A, Nomura Y, Tsujiuchi T, Shimizu K, Sasabe S, Park EY, Nakamura Y, Tsutsumi M, Sato K, J Agric Food Chem, J Agric Food Chem, 60, 940 - 945, 2012 , Refereed
  • Different effects on cell proliferation and migration abilities of endothelial cells by LPA1 and LPA3 in mammary tumor FM3A cells., Kitayoshi M, Fukui R, Tanabe E, Kato K, Yoshikawa K, Fukushima N, Tsujiuchi T, J Recept Signal Transduct Res, J Recept Signal Transduct Res, 32, 209 - 213, 2012 , Refereed
  • Comparison of gene expression profiling in sarcoma and mesenchymal stem cells identifies tumorigenic pathways in chemically induced rat sarcoma model., Honoki K, Fujii H, Tohma Y, Tsujiuchi T, Kido A, Tsukamoto S, Mori T, Tanaka Y, ISRN Oncol, ISRN Oncol, 2012 , Refereed
  • Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells., Tanabe E, Kitayoshi M, Yoshikawa K, Shibata A, Honoki K, Fukushima N, Tsujiuchi T, J Recept Signal Transduct Res, J Recept Signal Transduct Res, 32, 328 - 334, 2012 , Refereed
  • Regulation of cell motile activity through the different induction of LPA receptors by estrogens in liver epithelial WB-F344 cells., Tanabe E, Shibata A, Inoue S, Kitayoshi M, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 428, 105 - 109, 2012 , Refereed
  • Opposite roles of LPA1 and LPA3 on cell motile and invasive activities of pancreatic cancer cells., Kato K, Yoshikawa K, Tanabe E, Kitayoshi M, Fukui R, Fukushima N, Tsujiuchi T, Tumor Biol, Tumor Biol, 33, 1739 - 1744, 2012 , Refereed
  • Negative regulation of cell motile and invasive activities by lysophosphatidic acid receptor-3 in colon cancer HCT116 cells., Fukui R, Tanabe E, Kitayoshi M, Yoshikawa K, Fukushima N, Tsujiuchi T, Tumor Biol, Tumor Biol, 33, 1899 - 1905, 2012 , Refereed
  • Coodinated interactions between actin and microtubles through crosslinkers in neurite retration induced by lysophosphatidic acid., Fukishima N, Furuta D, Tsujiuchi T, Neurochem In, Neurochem In, 59, 109 - 113, Jun. 2011 , Refereed
  • Mutations and aberrant transcriptions of Stk11 (Lkb1) gene in rat liver tumors., Wakabayashi N, Okabe K, Hayashi M, Honoki K, Tsujiuchi T, Anticancer Res, Anticancer Res, 31, 543 - 547, 2011 , Refereed
  • Distinct DNA methylation patterns of lysophosphatidic acid receptor genes during rat hepatocarcinogenesis induced by a choline deficient L-amino acid defined diet., Okabe K, Hayashi M, Yoshida I, Nishimura K, Fukushima N, Tsujiuchi T, Arch Toxicol, Arch Toxicol, 85, 1303 - 1310, 2011 , Refereed
  • Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells., Hayashi M, Okabe K, Yamawaki Y, Teranishi M, Honoki K, Mori T, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 405, 450 - 454, 2011 , Refereed
  • Possible involvement of lysophosphatidic acid receptor-5 gene in the acquisition of growth advantage of rat tumor cells., Okabe K, Hayashi M, Yamawaki Y, Teranishi M, Honoki K, Mori T, Fukushima N, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 50, 635 - 642, 2011 , Refereed
  • Induction of lysophosphatidic acid receptor-3 by 12-O-tertadecanolphorbol-13-acetate stimulates cell migration of rat liver cells., Okabe K, Kato K, Teranishi M, Okumura M, Fukui R, Mori T, Fukushima N, Tsujiuchi T, Cancer Lett, Cancer Lett, 309, 236 - 242, 2011 , Refereed
  • No involvement of lysophosphatidic acid receptor-3 in cell migration of mouse lung tumor cells stimulated by 12-O-tetradecanoylphorbol-13-acetate., Okumura M, Kato K, Fukui R, Fukushima N, Tsujiuchi T, J Toxicol Pathol, J Toxicol Pathol, 24, 183 - 186, 2011 , Refereed
  • Genetic and epigenetic alterations of lysophosphatidic acid receptor genes in rodent tumors by experimental models., Tsujiuchi T, Okabe K, Fukushima N, J Toxicol Pathol, J Toxicol Pathol, 24, 143 - 148, 2011 , Refereed
  • Mesenchymal stem cells promote tumor engraftment and metastatic colonization in rat osteosarcoma model., Tsukamoto S, Honoki K, Fujii H, Tohma Y, Kido A, Mori T, Tsujiuchi T, Tanaka Y, Int J Oncol, Int J Oncol, 40, 163 - 169, 2011 , Refereed
  • Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells., Tsujino M, Fujii M, Okabe K, Mori T, Fukushima N, Tsujiuchi T, Virchows Arch, Virchows Arch, 457(6), 669 - 676, Dec. 2010 , Refereed
  • Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells, Okabe K, Hayashi M, Fujii M, Honoki K, Mori T, Fukushima N, Tsujiuchi T, Pathobiology, Pathobiology, 77(5), 278 - 282, Nov. 2010 , Refereed
  • Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance., Honoki K, Fujii H, Kubo A, Kido A, Mori T, Tanaka Y, Tsujiuchi T, Oncol Rep., Oncol Rep., 24, 501 - 505, 2010 , Refereed
  • Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in mouse tumor cells., Okabe K, Hayashi M, Wakabayashi N, Yamawaki Y, Teranishi M, Fukushima N, Tsujiuchi T, Pathobiology, Pathobiology, 77, 309 - 314, 2010 , Refereed
  • Mutations of LKB1 gene in pancreatic ductal adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters., Furukawa M, Yamasaki A, Yoshida J, Tsujino M, Wakabayashi N, Honoki K, Tsujiuchi T, Anticancer Res, Anticancer Res, 29(10), 4047 - 4050, Oct. 2009 , Refereed
  • Hydrogen sulfide as a novel mediator for pancreatic pain in rodents., Nishimura S, Fukushima O, Ishikura H, Takahashi T, Matsunami M, Tsujiuchi T, Sekiguchi F, Naruse M, Kamanaka Y, Kawabata A, Gut, Gut, 58(6), 762 - 770, Jun. 2009 , Refereed
  • Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors, Obo Y, Yamada T, Furukawa M, Hotta M, Honoki K, Fukushima N, Tsujiuchi T, 660(1-2), 47 - 50, 2009 , Refereed
  • Post-translational modifications of tubulin in the nervous system., Fukushima N, Furuta D, Hidaka Y, Moriyama R, Tsujiuchi T, J Neurochem., J Neurochem., 109, 683 - 693, 2009 , Refereed
  • Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats., Yamada T, Obo Y, Furukawa M, Hotta M, Yamasaki A, Honoki K, Fukushima N, Tsujiuchi T, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 378, 424 - 427, 2009 , Refereed
  • Infrequent mutation of lysophosphatidic acid receptor-1 gene in hamster pancreatic duct adenocarcinomas and established cell lines., Tsujiuchi T, Furukawa M, Obo Y, Yamasaki A, Hotta M, Kusunoki C, Suyama N, Mori T, Honoki K, Fukushima N, J Toxicol Pathol, J Toxicol Pathol, 22, 89 - 92, 2009 , Refereed
  • Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines., Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y, Int J Oncol, Int J Oncol, 34, 1381 - 1386, 2009 , Refereed
  • A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation., Shano S, Hatanaka K, Ninose S, Moriyama R, Tsujiuchi T, Fukushima N, Biochim Biophys Acta, Biochim Biophys Acta, 1783(5), 748 - 759, Jul. 2008 , Refereed
  • Reduced expression of the Rassf1a gene and its aberrant DNA methylation in pancreatic duct adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters., Shimizu K, Itsuzaki Y, Fujii H, Honoki K, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 47(2), 80 - 87, 2008 , Refereed
  • Numerical changes in the mitochondrial DNA displacement loop in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats, Onishi M, Saito M, Sokuza Y, Mori C, Nishikawa T, Shimizu K, Sugata E, Tsujiuchi T, Mutat Res, Mutat Res, 638(1-2), 133 - 138, 2008 , Refereed
  • Growth inhibition and induction of apoptosis by 2-methoxyestradiol in rat osteosarcoma and malignant fibrous histiocytoma cell lines., Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y, In Vivo, In Vivo, 22, 21 - 25, 2008 , Refereed
  • Reduced Expression of the Pcdh20 Gene and Its Aberrant DNA Methylation in Lung Adenocarcinomas Induced by N-nitrosobis(2-hydroxypropyl)amine in Rats., Sokuza Y, Yamada T, Obo Y, Furukawa M, Hotta M, Yamasaki A, Honoki K, Tsujiuchi T, J Toxicol Pathol, J Toxicol Pathol, 21, 257 - 260, 2008 , Refereed
  • Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats, Tsujiuchi T, Sugata E, Masaoka T, Onishi M, Fujii H, Shimizu K, Honoki K, Cancer Sci, Cancer Sci, 98(7), 943 - 948, Nov. 2007 , Refereed
  • Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats., Tsujiuchi T, Masaoka T, Sugata E, Onishi M, Fujii H, Shimizu K, Honoki K, Mol Carcinog, Mol Carcinog, 46(10), 819 - 823, Oct. 2007 , Refereed
  • Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats., Onishi M, Sokuza Y, Nishikawa T, Mori C, Uwataki K, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun, Biochem Biophys Res Commun, 362(1), 183 - 187, Oct. 2007 , Refereed
  • Disturbance of DNA methylation patterns in the early phase of hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats, Shimizu K, Onishi M, Sugata E, Sokuza Y, Mori C, Nishikawa T, Honoki K, Tsujiuchi T, Cancer Sci., Cancer Sci., 98(9), 1318 - 1322, Sep. 2007 , Refereed
  • CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats, Tsujiuchi T, Shimizu K, Itsuzaki Y, Onishi M, Sugata E, Fujii H, Honoki K, Mol Carcinog, Mol Carcinog, 46(4), 269 - 274, Apr. 2007 , Refereed
  • Aberrant DNA methylation of the 5' upstream region of Tslc1 gene in hamster pancreatic tumors., Shimizu K, Onishi M, Sugata E, Fujii H, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun, Biochem Biophys Res Commun, 353(2), 522 - 526, Feb. 2007 , Refereed
  • The proteinase inhibitor camostat mesilate suppressed pancreatic pain in rodents., Ishikura H, Nishimura S, Matsunami M, Tsujiuchi T, Ishiki T, Sekiguchi F, Naruse M, Nakatani T, Kamanaka Y, Kawabata A, Life Sci, Life Sci, 98, 1318 - 1322, 2007 , Refereed
  • Prognostic significance of p16 (INK4a) alterations for Ewing sarcoma: a meta-analysis., Honoki K, Stojanovski E, McEvoy M, Fujii H, Tsujiuchi T, Kido A, Takakura Y, Attia J, Cancer, Cancer, 110, 1351 - 1360, 2007 , Refereed
  • Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas., Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Mori T, Takakura Y, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 362, 773 - 778, 2007 , Refereed
  • Absence of mitochondrial DNA displacement loop mutations in hamster pancreatic duct adenocarcinomas and established cell lines, Onishi M, Saito M, Sokuza Y, Mori C, Nishikawa T, Mori T, Tsujiuchi T, J. Toxicol. Patho, J. Toxicol. Patho, 20, 263 - 266, 2007 , Refereed
  • Involvement of aberrant DNA methylation on reduced expression of lysophosphatidic acid receptor-1 gene in rat tumor cell lines., Tsujiuchi T, Shimizu K, Onishi M, Sugata E, Fujii H, Mori T, Honoki K, Fukushima N, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 349(3), 1151 - 1155, Oct. 2006 , Refereed
  • Reduced expression of the Connexin26 gene and its aberrant DNA methylation in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine, Shimizu K, Shimoichi Y, Hinotsume D, Itsuzaki Y, Fujii H, Honoki K, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 45(9), 710 - 714, Sep. 2006 , Refereed
  • Reduced expression of the Tslc1 gene and its aberrant DNA methylation in rat lung tumors, Shimizu K, Itsuzaki Y, Onishi M, Fujii H, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun, Biochem Biophys Res Commun, 347(1), 358 - 362, Aug. 2006 , Refereed
  • Reduced expressions of Foxp1 and Rassf1a genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats., Shimizu K, Kato A, Hinotsume D, Shigemura M, Hanaoka M, Shimoichi Y, Honoki K, Tsujiuchi T, Cancer Lett, Cancer Lett, 236(2), 186 - 190, May 2006 , Refereed
  • Aberrant methylation patterns of the Rassf1a gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine., Shimizu K, Kato A, Shigemura M, Fujii H, Honoki K, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 45(2), 112 - 117, Apr. 2006 , Refereed
  • Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine., Kato A, Shimizu K, Shimoichi Y, Fujii H, Honoki K, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 45(2), 106 - 111, Feb. 2006 , Refereed
  • Reduced expressions of the Connexin26 gene and its aberrant DNA methylation in rat lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl) amine., Shimizu K, Shimoichi Y, Hinotsume D, Itsuzaki Y, Fujii H, Honoki K, Tsujiuchi T, Mol Carcinog, Mol Carcinog, 45, 710 - 714, 2006 , Refereed
  • Alterations in the Smad4 gene in hamster pancreatic duct adenocarinomas and establishied cell lines., Shimizu K, Kitahashi T, Fujii H, Tsutsumi M, Mori T, Honoki K, Tsujiuchi T, Oncol Rep, Oncol Rep, 16, 85 - 89, 2006 , Refereed
  • Aberrant expressions of lysophosphatidic acid receptor genes in lung and liver tumors of rats., Tsujiuchi T, Shimizu K, Onishi M, shigemura M, Shano S, Honoki K, Fukushima N, J Toxicol Pathol, J Toxicol Pathol, 19, 137 - 142, 2006 , Refereed
  • Reduced expression of the E-cadherin gene and its aberrant DNA methylation in hamster pancreatic tumors., Shimizu K, Hanaoka M, Kato A, Fujii H, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun, Biochem Biophys Res Commun, 336, 49 - 53, Oct. 2005 , Refereed
  • Cloning of the hamster p16 gene 5' upstream region and its aberrant methylation patterns in pancreatic cancer., Hanaoka M, Shimizu K, Shigemura M, Kato A, Fujii H, Honoki K, Tsujiuchi T, Biochem Biophys Res Commun, Biochem Biophys Res Commun, 333, 1249 - 1253, Aug. 2005 , Refereed
  • Establishment and characterization of a rat lung adenocaricnoma cell line with low malignant potential., Tsujiuchi T, Mori T, Amanuma T, Tanaka N, Tsutsumi M, Cancer Lett, Cancer Lett, 217, 97 - 103, 2005 , Refereed
  • Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines., Honoki K, Tsujiuchi T, Mori T, Yoshitani K, Tsutsumi M, Takakura Y, Mii Y, Mol Carcinog, Mol Carcinog, 39, 10 - 14, 2004 , Refereed
  • Alterations of the M6p/Igf2 receptor gene in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats., Tsujiuchi T, Sasaki Y, Oka Y, Kuniyasu H, Konishi Y, Tsutsumi M, Mol Carcinog, Mol Carcinog, 39, 199 - 205, 2004 , Refereed
  • Growth inhibition and iduction of apoptosis by flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines., Honoki K, Yoshitani K, Tsujiuchi T, Mori T, Tsutsumi M, Morishita T, Takakura Y, Mii Y, Oncol Rep, Oncol Rep, 11, 1025 - 1030, 2004 , Refereed
  • Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl) amine in rats., Tsujiuchi T, Sasaki Y, Oka Y, Kuniyasu H, Tsutsumi M, Mol Carcinog, Mol Carcinog, 40, 241 - 246, 2004 , Refereed
  • Aberrant transcrption of Fhit gene in intrahepatic cholangiocellular carcinomas induced by N-nitroso(2-oxopropyl)amine in hamsters., Kitahashi T, Tsujiuchi T, Satoh K, Ohtsuki K, Konishi Y, Tsutsumi M, ExpToxicol Pathol, ExpToxicol Pathol, 56, 153 - 157, 2004 , Refereed
  • Alterations of the M6p/Igf2 receptor gene in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl) amine in rats., Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y, Mol Carcinog, Mol Carcinog, 36, 32 - 37, 2003 , Refereed
  • Alterations in the FHIT gene in pancreatic duct adenocarcinomas induced by N-nitrosobis (2-oxopropyl) amine in hamsters., Tsujiuchi T, Sasaki Y, Kubozoe T, Konishi Y, Tsutsumi M, Mol Carcinog, Mol Carcinog, 36, 60 - 66, 2003 , Refereed
  • FHIT gene alterations in hepatocellular carcinomas induced by a choline-deficient L-amino acid-defined diet in rats., Tsujiuchi T, Sasaki Y, Oka Y, Konishi Y, Tsutsumi M, Mol Carcinog, Mol Carcinog, 36, 147 - 152, 2003 , Refereed
  • Molecular aspects during multi-step chemical induced carcinogenesis in the lung and pancreas, Tsujiuchi T, Tsutsumi M, Konishi Y, J Toxicol Pathol, J Toxicol Pathol, 16, 133 - 138, 2003 , Refereed
  • Differential expression of cytokines in rat osteosarcoma and malignant fibrous histiocytoma cell lines induced by 4-(hydroxyamino) quinoline- 1-oxide., Honoki K, Tsujiuchi T, Sasaki Y, Tsutsumi M, Morishita T, Kido A, Miyauchi Y, Mii Y, Takakura Y, Konishi Y, Mol Carcinog, Mol Carcinog, 33, 81 - 87, 2002 , Refereed
  • Possible lack of carcinogenic potential of 9-(4'- aminophenyl)- 9H- pyrido [3,4-b] indole (aminophenylnorharman) for the pancreatic duct epithelium in hamsters., Kubozoe T, Tsutsumi M, Murata N, Tsujiuchi T, Tsunoda T, Sugimura T, Wakabayashi K, Konishi Y, J Toxicol Pathol, J Toxicol Pathol, 15, 7 - 12, 2002 , Refereed
  • Development of hepatocellular adenomas and carcinomas associated with fibrous in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet, Denda A, Kitayama W, Kishida H, Murata N, Tsutsumi M, Tsujiuchi T, Nakae D, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 93, 125 - 132, 2002 , Refereed
  • Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide., Denda A, Kitayama W, Murata A, Kishida H, Sasaki Y, Kusuoka O, Tsujiuchi T, Tsutsumi M, Nakae D, Takagi H, Konishi Y, Carcinogenesis, Carcinogenesis, 23, 245 - 256, 2002 , Refereed
  • Alterations of the FHIT gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats., Tsujiuchi T, Sasaki Y, Kubozoe T, Tsutsumi M, Konishi Y, Nakae D, Mol Carcinog, Mol Carcinog, 34, 19 - 24, 2002 , Refereed
  • Alterations of the retinoblastoma- related gene RB2/p130 in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl) amine in rats., Tsujiuchi T, Sasaki Y, Konishi Y, Tsutsumi M, Mol Carcinog, Mol Carcinog, 35, 57 - 62, 2002 , Refereed
  • Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl)amine in rats., Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y, Cancer Lett, Cancer Lett, 162, 207 - 211, 2001 , Refereed
  • Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity., Tsutsumi M, Masutani M, Nozaki T, Kusuoka O, Tsujiuchi T, Nakagama H, Suzuki H, Konishi Y, Sugimura T, Carcinogenesis, Carcinogenesis, 22, 16 - 22, 2001 , Refereed
  • Interleukin-15 expression is associated with malignant potential in colon cancer cells., Kuniyasu H, Oue N, Nakae D, Tsutsumi M, Denda A, Tsujiuchi T, Yokozaki H, Yasui W, Pathobiology, Pathobiology, 69, 86 - 95, 2001 , Refereed
  • Lack of effects of bisphenol A in maternal rats or treatment on response of their offspring to N-nitrosobis (2-hydroxypropyl) amine in rats., Takashima Y, Tsutsumi M, Sasaki Y, Tsujiuchi T, Kusuoka O, Konishi Y, J Toxicol Pathol, J Toxicol Pathol, 14, 87 - 98, 2001 , Refereed
  • Elevated expression of transforming growth factor beta and the tumor necrosis factor family in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl)amine in rats., Tsujiuchi T, Sasaki Y, Murata N, Tsutsumi M, Nakae D, Konishi Y, Exp Toxcol Pathol, Exp Toxcol Pathol, 53, 291 - 295, 2001 , Refereed
  • FHIT alterations in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl)amine in rats., Tsujiuchi T, Sasaki Y, Murata N, Tsutsumi M, Konishi Y, Nakae D, Carcinogenesis, Carcinogenesis, 22, 2017 - 2022, 2001 , Refereed
  • Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats., Sasaki Y, Tsujiuchi T, Murata N, Tsutsumi M, Konishi Y, Jpn J Cancer Res., Jpn J Cancer Res., 92, 16 - 22, 2001 , Refereed
  • Absence of beta-catenin gene mutations in pancreatic duct lesions induced by N-nitrosobis(2-oxopropyl)amine in hamsters., Kubozoe T, Tsujiuchi T, Murata N, Sasaki Y, Tsunoda T, Konishi Y, Tsutsumi M, Cancer Lett., Cancer Lett., 168, 1 - 6, 2001 , Refereed
  • Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis (2-hydroxypropyl) amine., Kitayama W, Denda A, Yoshida J, Sasaki Y, Takahama M, Murakawa K, Tsujiuchi T, Tsutsumi M, Konishi Y, Cancer Lett, Cancer Lett, 148, 145 - 152, 2000 , Refereed
  • Inhibitory effects of combined administration of antibiotics and anti- inflammatory drugs on lung tumor development initiated by N-nitrosobis (2-hydroxypropyl) amine in rats., Tsutsumi M, Kitada H, Shiraiwa K, Takahama M, Tsujiuchi T, Sakitani H, Sasaki Y, Murakawa K, Yoshimoto M, Konishi Y, Carcinogenesis, Carcinogenesis, 21, 251 - 256, 2000 , Refereed
  • Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrodiethylamine or choline-deficient L-amino acid defined diet in rats., Sasaki Y, Tsujiuchi T, Murata N, Kubozoe T, Tsutsumi M, Konishi Y, Cancer Lett, Cancer Lett, 152, 71 - 77, 2000 , Refereed
  • Isolation and localization of type IIb Na/Pi cotransporter in the development rat lung., Hashimoto M, Wang DY, Kamo T, Zhu Y, Tsujiuchi T, Konishi Y, Tanaka M, Sugimura H, Am J Pathol, Am J Pathol, 157, 21 - 27, 2000 , Refereed
  • .Possible involvement of bcl-2 suppression in wild-type p53 gene dependent cell growth repression in rat osteosarcoma cells., Honoki K, Tsujiuchi T, Tsutsumi M, Kido A, Morishita T, Yoshimoto M, Miyauchi Y, Mii Y, Tamai S, Konishi Y, Toxicol Path, Toxicol Path, 28, 575 - 579, 2000 , Refereed
  • Mutations of Smad2 and Smad4 genes in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl)amine in rats., Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y, Mol Carcinog, Mol Carcinog, 29, 87 - 91, 2000 , Refereed
  • Elevated expression of interleukins in lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl)amine in rats., Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 91, 955 - 959, 2000 , Refereed
  • Overexpression of midkine in pancreatic duct adenocarcinomas induced by N-nitrosobis (2-oxopropyl) amine in hamsters and their cell lines., Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 91, 979 - 986, 2000 , Refereed
  • Mutations and reduced expression of the transforming growth factor-b receptor II gene in rat lung adenocarcinomas induced by N-nitrosobis (2-hydroxypropyl) amine., Tsujiuchi T, Sasaki Y, Tsutsumi M, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 91, 1090 - 1095, 2000 , Refereed
  • Mutations of adenomatous polyposis coli and b-catenin genes during progression of lung tumors induced by N-nitrosobis (2-hydroxypropyl)amine in rats., Tsujiuchi T, Tsutsumi M, Sasaki Y, Murata N, Konishi Y, Cancer Res, Cancer Res, 60, 6611 - 6616, 2000 , Refereed
  • Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules induced by a choline-deficient L-amino acid-defined diet in rats., Tsujiuchi T, Tsutsumi M, Sasaki Y, Takahama M, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 90, 909 - 913, 1999 , Refereed
  • Enhanced expression of tie2, its ligand angiopoietin-1, vascular endothelial factor, and CD31 in human non-small cell lung carcinomas., Takahama M, Tsutsumi M, Tsujiuchi T, Nezu K, Kushibe K, Taniguchi S, Kotake Y, Konishi Y, Clin Cancer Res, Clin Cancer Res, 5, 1506 - 1510, 1999 , Refereed
  • Different frequencies and patterns of b-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats., Tsujiuchi T, Tsutsumi M, Sasaki Y, Takahama M, Konishi Y, Cancer Res, Cancer Res, 59, 3904 - 3907, 1999 , Refereed
  • Cloning of differentially expressed genes in highly and low metastatic rat osteosarcomas by a modified DNA-AFLP method., Fukuda T, Kido A, Kajino K, Tsutsumi M, Miyauchi Y, Tsujiuchi T, Konishi Y, Hino O, Biochem Biophys Res Commun., Biochem Biophys Res Commun., 261, 35 - 40, 1999 , Refereed
  • Over expression of matrix metalloproteinase (MMP)-9 correlates with metastatic potency of spontaneous and 4-hydroxyaminoquinoline 1-oxide (4HAQO)-induced transplantable osteosarcomas in rats., Kido A, Tsutsumi M, Iki K, Takahama M, Tsujiuchi T, Morishita T, Tamai S, Konishi Y, Cancer Lett, Cancer Lett, 137, 209 - 216, 1999 , Refereed
  • Expression of vascular endothelial growth factor and its receptors during lung carcinogenesis by N-nitrosobis (2-hydroxypropyl) amine in rats., Takahama M, Tsutsumi M, Tsujiuchi T, Kido A, Sakitani H, Iki K, Taniguchi S, Kitamura S, Konishi Y, Mol Carcinog, Mol Carcinog, 24, 287 - 293, 1999 , Refereed
  • Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4- (N-hydroxyamino]- 2R- isobutylsuccinyl] amino- 1-methoxy-3, 4-dihydrocarbostyril, a novel matrix metalloproteinase inhibitor., Kido A, Tsutsumi M, Iki K, Motoyama M, Takahama M, Tsujiuchi T, Morishita T, Tatsumi K, Tamai S, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 90, 333 - 341, 1999 , Refereed
  • Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl- N-(4-hydroxybutyl) nitrosamine., Kitayama W, Denda A, Okajima E, Tsujiuchi T, Konishi Y, Carcinogenesis, Carcinogenesis, 20, 2305 - 2310, 1999 , Refereed
  • Overexpression of midkine in lung tumors induced by N-nitrosobis (2-hydroxypropyl) amine in rats and its increase with progression., Sakitani H, Tsutsumi M, Kadomatsu K, Ikematsu S, Takahama M, Iki K, Tsujiuchi T, Muramatsu T, Sakuma S, Sakaki T, Konishi Y, Carcinogenesis, Carcinogenesis, 20, 465 - 469, 1999 , Refereed
  • Carcinogenicity of heterocyclic amines for the pancreatic duct epithelium in hamsters., Yoshimoto M, Tsutsumi M, Iki K, Sasaki Y, Tsujiuchi T, Sugimura T, Wakabayashi K, Konishi Y, Cancer Lett., Cancer Lett., 143, 235 - 239, 1999 , Refereed
  • Inhibition by phenyl N-tret- butyl nitrone of early phase carcinogenesis in the livers of rats fed a coline-deficient, L-amino acid-defined diet., Nakae D, Kotake Y, Kishida H, Hensley KL, Denda A, Kobayashi Y, Kitayama W, Tsujiuchi T, Sang H, Stewart CA, Tabatabaie T, Floyd RA, Konishi Y, Cancer Res, Cancer Res, 58, 4548 - 4551, 1998 , Refereed
  • Telomerase activity correlates with growth of transplantable osteosarcomas in rats treated with cis-diammine dichloroplatinum or the angiogenesis inhibitor AGM-1470., Kido A, Tsujiuchi T, Morishita T, Tsutsumi M, Takahama M, Miyauchi Y, Mii Y, Tamai S, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 89, 1074 - 1081, 1998 , Refereed
  • Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic harboring a rat glutathione S-transferase placental form gene., Nakae D, Denda A, Kobayashi Y, Akai H, Kishida H, Tsujiuchi T, Konishi Y, Suzuki T, Muramatsu M, Jpn J Cancer Res, Jpn J Cancer Res, 89, 1118 - 1125, 1998 , Refereed
  • Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesion in the livers of rats fed a choline-defficient, L-amino acid-defined diet., Kobayashi Y, Nakae D, Akai H, Kishida H, Okajima E, Kitayama W, Denda A, Tsujiuchi T, Murakami A, Koshimizu K, Ohigashi H, Konishi Y, Carcinogenesis, Carcinogenesis, 19, 1809 - 1814, 1998 , Refereed
  • Increased telomerase activity in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis (2-oxopropyl) amine in hamsters., Iki K, Tsujiuchi T, Majima T, Sakitani H, Tsutsumi M, Takahama M, Yoshimoto M, Nakae D, Tsunoda T, Konishi Y, Cancer Lett, Cancer Lett, 131, 185 - 190, 1998 , Refereed
  • Mechanistic analysis of pancreatic ductal carcinogenesis in hamsters., Konishi Y, Tsutsumi M, Tsujiuchi T, Pancreas, Pancreas, 16, 300 - 306, 1998 , Refereed
  • Prevention by inhibitors of arachidonic cascade of liver carcinogenesis, cirrhosis and oxidative DNA damage caused by a choline-deficient, L-amino acid-defined diet in rats., Denda A, Endoh T, Tang Q, Tsujiuchi T, Nakae D, Konishi Y, Mutat Res, Mutat Res, 402, 279 - 288, 1998 , Refereed
  • Heterogenous pattern of gene expression in cloned cell lines established from a rat transplantable osteosarcoma lung metastatic nodules., Honoki K, Mori T, Tsutsumi M, Tsujiuchi T, Kido A, Morishita T, Miyauchi Y, Dohi Y, Mii Y, Tamai S, Konishi Y, Cancer Lett, Cancer Lett, 127, 221 - 228, 1998 , Refereed
  • Systemic mast cell disease with splenic infarction: a case report., Maruyama H, Sugihara S, Ishihara K, Sada K, Tsutsumi M, Tsujiuchi T, Nakae D, Konishi Y, Pathol Int, Pathol Int, 48, 403 - 411, 1998 , Refereed
  • Frequent expression of the vascular endothelial growth factor in human non-small-cell lung cancers., Takahama M, Tsutsumi M, Tsujiuchi T, Kido A, Okajima E, Nezu K, Tojo T, Kushibe K, Kitamura S, Konishi Y, Jpn J Clin Oncol, Jpn J Clin Oncol, 28, 176 - 181, 1998 , Refereed
  • Increased telomerase activity and absence of p53 mutation in oligo- astrocytomas induced by N-ethyl- N-nitrosourea in rats., Sakitani H, Tsujiuchi T, Kobitsu K, Kido A, Iki K, Takahama M, Nakamura M, Sakaki T, Nakae D, Konishi Y, Tsutsumi M, Cancer Lett, Cancer Lett, 126, 157 - 164, 1998 , Refereed
  • Induction of telomerase activity during regeneration after partial hepatectomy in the rat., Tsujiuchi T, Tsutsumi M, Kido A, Takahama M, Sakitani H, Iki K, Sasaki Y, Denda A, Konishi Y, Cancer Lett, Cancer Lett, 122, 115 - 120, 1998 , Refereed
  • Telomerase activity in experimental animal tumors., Tsujiuchi T, Tsutsumi M, Konishi Y, Exp Toxicol Pathol., Exp Toxicol Pathol., 50, 1998 , Refereed
  • Inhibitory by green tea extract of diethylnitrosamine- initiated but not a choline deficient, L-amino acid-defined diet- associated development of putative preneoplastic, glutathione S-transferase placental form- positive lesions in rat liver., Tamura K, Nakae D, Horiguchi K, Akai H, Kobayashi Y, Satoh H, Tsujiuchi T, Denda A, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 88, 356 - 362, 1997 , Refereed
  • Chronic toxicity and carcinogenicity studies of 2-methylnaphtalene in B6C3F1 mice., Murata Y, Denda A, Maruyama H, Nakae D, Tsutsumi M, Tsujiuchi T, Konishi Y, Fundam Appl Toxicol, Fundam Appl Toxicol, 36, 90 - 93, 1997 , Refereed
  • Increased telomerase activation in human pancreatic duct adenocarcinomas., Tsutsumi M, Tsujiuchi T, Ishikawa O, Majima T, Yoshimoto M, Sasaki Y, Fukuda T, Oohigashi H, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 88, 971 - 976, 1997 , Refereed
  • Inhibition by n-(4-hydroxyphenyl) retinamide and all-trans retinoic acid of exogenous and endogenous development of putative preneoplastic glutathione S- tranferase placental form-positive lesions in the livers of rats., Tamura K, Nakae D, Horiguchi K, Akai H, Kobayashi Y, Andoh N, Satoh H, Denda A, Tsujiuchi T, Yoshiji H, Konishi Y, Carcinogenesis, Carcinogenesis, 18, 2133 - 2141, 1997 , Refereed
  • Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats., Denda A, Endoh T, Kitayama W, Tang Q, Noguchi O, Kobayashi Y, Akai H, Okajima E, Tsujiuchi T, Tsutsumi M, Nakae D, Konishi Y, Carcinogenesis, Carcinogenesis, 18, 1921 - 1930, 1997 , Refereed
  • Mutations of K-ras but not p53 genes in biliary duct and pancreatic duct carcinogenesis induced in hamsters by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis (2-oxopropyl) amine., Majima T, Tsujiuchi T, Tsutsumi M, Tsunoda T, Konishi Y, Cancer Lett, Cancer Lett, 118, 47 - 53, 1997 , Refereed
  • Hot-spot mutations in the p53 gene of liver nodules induced in rats fed DL-ethionine with a methyl-deficient diet., Tsujiuchi T, Yeleswarapu L, Konishi Y, Lombardi B, Br J Cancer, Br J Cancer, 76, 15 - 20, 1997 , Refereed
  • Increased telomerase activity is not directly related to metastatic potential in rat transplantable osteosarcomas., Kido A, Tsujiuchi T, Tsutsumi M, Takahama M, Miyauchi Y, Mii Y, Tamai S, Konishi Y, Cancer Lett, Cancer Lett, 117, 67 - 71, 1997 , Refereed
  • Shortend telomere length and increased telomerase activity in hamster pancreatic duct adenocarcinomas and cell lines., Kobitsu K, Tsutsumi M, Tsujiuchi T, Suzuki F, Kido A, Okajima E, Fukuda T, Sakaki T, Konishi Y, Mol Carcinog, Mol Carcinog, 11, 153 - 159, 1997 , Refereed
  • p53 mutation and absence of mdm2 amplification and Ki-ras mutation in 4-hydroxyamino quinoline 1-oxide induced transplantable osteosarcomas in rats., Kido A, Tsujiuchi T, Tsutsumi M, Takahama M, Okajima E, Kobitsu K, Miyauchi Y, Mii Y, Tamai S, Konishi Y, Cancer Lett, Cancer Lett, 112, 5 - 10, 1997 , Refereed
  • Lack of significant tumor induction by endogenously formed N- nitrosobis (2-hydroxypropyl) amine in rats fed tris (2-hydroxypropyl) amine and sodium nitrite., Yamamoto K, Tsutsumi M, Tsujiuchi T, Kobitsu K, Okajima E, Takahama M, Mori Y, Konishi Y, J Toxicol Pathol, J Toxicol Pathol, 9, 199 - 204, 1996 , Refereed
  • Shortened telomere length in hepatocellular carcinomas and corresponding background liver tissue of patients infected with hepatitis virus., Ohashi K, Tsutsumi M, Kobitsu K, Fukuda T, Tsujiuchi T, Okajima E, Ko S, Nakajima Y, Nakano H, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 87, 419 - 422, 1996 , Refereed
  • Frequent mutations of Ki-ras but no mutations of H-ras and p53 in lung lesions induced by N- nitrosobis (2-hydroxypropyl) amine in rats., Kitada H, Tsutsumi M, Tsujiuchi T, Takahama M, Fukuda T, Narita N, Konsihi Y, Mol Carcinog, Mol Carcinog, 15, 276 - 283, 1996 , Refereed
  • Inhibition by acetylsalicylic acid, a cyclooxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient L-amino acid-defined diet in rats., Endoh T, Tang Q, Denda A, Noguchi O, Kobayashi E, Tamura K, Horiguchi K, Ogasawara H, Tsujiuchi T, Nakae D, Sugimura M, Konishi Y, Carcinogenesis, Carcinogenesis, 17, 467 - 475, 1996 , Refereed
  • Disturbance of the cell cylcle with colchicine enhances the growth advantage of diethylnitrosamine- initiated hepatocytes in rats., Tsutsumi M, Ohashi K, Tsujiuchi T, Kobayashi E, Kobitsu K, Kitada H, Majima T, Okajima E, Endoh T, Hasegawa K, Mori T, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 87, 5 - 9, 1996 , Refereed
  • Inhibitory effects of N,N'-diphenyl-p-phenylenediamine on the early stage of the enhanced hepatocarcinogenesis caused by coadministration of ethionine and a choline-deficient L-amino acid-defined diet in rats., Kobayashi E, Tsujiuchi T, Nakae D, Mizumoto Y, Andoh N, Endoh T, Kitada H, Tsutsumi M, Denda A, Konishi Y, Exp Toxicol Pathol., Exp Toxicol Pathol., 48, 275 - 282, 1996 , Refereed
  • Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicine-induced cell cycle disturbance in partially hepatectomized rats., Ohashi K, Tsutsumi M, Tsujiuchi T, Kobitsu K, Okajima E, Nakajima Y, Nakano H, Takahashi M, Mori Y, Konishi Y, Cancer Res., Cancer Res., 56, 3474 - 3479, 1996 , Refereed
  • Increased telomerase activity in hyperplastic nodules and hepatocellular carcinomas induced by a choline-deficient L-amino acid-defined diet in rats., Tsujiuchi T, Tsutsumi M, Kido A, Kobitsu K, Takahama M, Majima T, Denda A, Nakae D, Konishi Y, Jpn J Cancer Res., Jpn J Cancer Res., 87, 1111 - 1115, 1996 , Refereed
  • Infrequent Ki-ras and an absence of p53 mutations in hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats., Tsujiuchi T, Kido A, Nakae D, Takahama M, Majima T, Kobitsu K, Okajima E, Tsutsumi M, Denda A, Konishi Y, Cancer Lett., Cancer Lett., 108, 137 - 141, 1996 , Refereed
  • Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters., Tsutsumi M, Noguchi O, Okita S, Horiguchi K, Kobayashi E, Tamura K, Tsujiuchi T, Denda A, Konishi Y, Iimura K, Carcinogenesis, Carcinogenesis, 16, 457 - 459, 1995 , Refereed
  • Comparative changes in the liver of female Fischer-344 rats after short-term feeding of a semipurified or a semisynthetic L-amino acid-defined choline-deficient diet., Nakae D, Mizumoto Y, Andoh N, Tamura K, Horiguchi K, Endoh T, Kobayashi E, Tsujiuchi T, Denda A, Lombardi B, Toxicol Pathol., Toxicol Pathol., 23, 583 - 590, 1995 , Refereed
  • Prevention by Methionine of Enhancement of Hepatocarcinogenesis by coadministration of a choline-deficient L-amino acid-defined diet and ethionine in Rats, Tsujiuchi T, Kobayashi E, Nakae D, Mizumoto Y, Andoh N, Kitada H, Ohashi K, Fukuda T, Kido A, Tsutsumi M, Japanease Journal of Cancer Research, Japanease Journal of Cancer Research, 86, 1136 - 1142, 1995 , Refereed
  • Expression of cripto in human pancreatic tumors., Tsutsumi M, Yasui W, Naito A, Ohashi K, Kobayashi E, Noguchi O, Horiguchi K, Okita S, Tsujiuchi T, Kitada H, Jpn J Cancer Res., Jpn J Cancer Res., 85, 118 - 121, 1994 , Refereed
  • Inhibitory effects of 2-O-octadecylascorbic acid and other vitamin C and E derivatives on the induction of enzyme-altered putative preneoplastic lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet., Mizumoto Y, Nakae D, Yoshiji H, Andoh N, Horiguchi K, Endoh T, Kobayashi E, Tsujiuchi T, Shimoji N, Denda A, Carcinogenesis, Carcinogenesis, 15, 241 - 246, 1994 , Refereed
  • Inhibition by catechol and di(2-ethylhexyl)phthalate of pancreatic carcinogenesis after initiation with N-nitrosobis(2-hydroxypropyl)amine in Syrian hamsters., Maruyama H, Amanuma T, Tsutsumi M, Tsujiuchi T, Horiguchi K, Denda A, Konishi Y, Carcinogenesis, Carcinogenesis, 15, 1193 - 1196, 1994 , Refereed
  • Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as generations of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, L-amino acid-defined diet in rats., Denda A, Tang Q, Endoh T, Tsujiuchi T, Horiguchi K, Noguchi O, Mizumoto Y, Nakae D, Konishi Y, Carcinogenesis, Carcinogenesis, 15, 1279 - 1283, 1994 , Refereed
  • Effects of novobiocin on the induction of gamma-glutamyltranspeptidase positive foci in the liver of rats treated with diethylnitrosamine., Tsujiuchi T, Tsutsumi M, Honoki K, Horiguchi K, Kobayashi E, Denda A, Konishi Y, Exp Toxicol Pathol., Exp Toxicol Pathol., 46, 115 - 118, 1994 , Refereed
  • High rates of Ki-ras point mutation in both intra- and extra-hepatic cholangiocarcinomas., Ohashi K, Tsutsumi M, Nakajima Y, Noguchi O, Okita S, Kitada H, Tsujiuchi T, Kobayashi E, Nakano H, Konishi Y, Jpn J Clin Oncol., Jpn J Clin Oncol., 24, 305 - 310, 1994 , Refereed
  • Effects of oxidative stress induced by redox-enzyme modulation on the progression stage of rat hepatocarcinogenesis., Denda A, Tang Q, Tsujiuchi T, Tsutsumi M, Amanuma T, Murata Y, Tamura K, Horiguchi K, Nakae D, Konishi Y, Carcinogenesis, Carcinogenesis, 14, 95 - 101, 1993 , Refereed
  • Correlation between lack of bone Gla protein mRNA expression in rat transplantable osteosarcomas and expression of both c-fos and c-jun proto-oncogenes., Honoki K, Dohi Y, Tabata S, Mii Y, Miyauchi Y, Tsutsumi M, Tsujiuchi T, Morishita T, Miura S, Moriyama T, Mol Carcinog., Mol Carcinog., 7, 111 - 115, 1993 , Refereed
  • Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure., Tang Q, Denda A, Tsujiuchi T, Tsutsumi M, Amanuma T, Murata Y, Maruyama H, Konishi Y, Jpn J Cancer Res., Jpn J Cancer Res., 84, 120 - 127, 1993 , Refereed
  • Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-hydroxypropyl)amine., Tsutsumi M, Murakami Y, Kondoh S, Tsujiuchi T, Hohnoki K, Horiguchi K, Noguchi O, Kobayashi E, Okita S, Sekiya T, Jpn J Cancer Res., Jpn J Cancer Res., 84, 956 - 960, 1993 , Refereed
  • Increased expression of nucleoside diphosphate kinase/nm23 and c-Ha-ras mRNA is associated with spontaneous lung metastasis in rat-transplantable osteosarcomas., Honoki K, Tsutsumi M, Miyauchi Y, Mii Y, Tsujiuchi T, Morishita T, Miura S, Aoki M, Kobayashi E, Tamai S, Cancer Res, Cancer Res, 53, 5038 - 5042, 1993 , Refereed
  • K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters., Tsutsumi M, Kondoh S, Noguchi O, Horiguchi K, Kobayashi E, Okita S, Ohashi K, Honoki K, Tsujiuchi T, Konishi Y, 84, 1101 - 1105, 1993 , Refereed
  • Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver., Denda A, Sai KM, Tang Q, Tsujiuchi T, Tsutsumi M, Amanuma T, Murata Y, Nakae D, Maruyama H, Kurokawa Y, Carcinogenesis, Carcinogenesis, 12, 719 - 726, 1991 , Refereed
  • Initiating activity of diethylnitrosamine in a rapid production model for pancreatic carcinomas in Syrian hamsters., Amanuma T, Mizumoto K, Tsutsumi M, Tsujiuchi T, Kitazawa S, Hasegawa K, Denda A, Maruyama H, Konishi Y, Jpn J Cancer Res, Jpn J Cancer Res, 82, 632 - 637, 1991 , Refereed
  • Effects of 3-aminobenzamide on induction of multiorgan carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine in hamsters., Tsujiuchi T, Tsutsumi M, Denda A, Amanuma T, Kondoh S, Kamino K, Konishi Y, Jpn J Cancer Res., Jpn J Cancer Res., 82, 793 - 799, 1991 , Refereed
  • Effects of catechol and its analogs on pancreatic carcinogenesis initiated by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters., Maruyama H, Amanuma T, Nakae D, Tsutsumi M, Kondo S, Tsujiuchi T, Denda A, Konishi Y, Carcinogenesis, Carcinogenesis, 12, 1331 - 1334, 1991 , Refereed
  • Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters., Tsujiuchi T, Mizumoto K, Tsutsumi M, Denda A, Amanuma T, Kondoh S, Konishi Y, Cancer Lett., Cancer Lett., 61, 61 - 66, 1991 , Refereed

Conference Activities & Talks

  • Involvement of endogenous hydrogen sulfide in acute pancreatitis-related pain., 6th FENS Forum of European Neuroscience,   2008 07 , 6th FENS Forum of European Neuroscience
  • Hydrogen sulfide as a nociceptive messenger in rat and mouse pancreata., Neuroscience 2007,   2007 11 , Neuroscience 2007

Misc

  • 培養海馬神経細胞におけるLPA3を介する軸索分岐形成の分子メカニズム(Molecular mechanism of LPA3-Mediated axonal branching formation in cultured hippocampal neurons), 古田 大祐, 山根 昌之, 森山 隆太郎, 藤田 典久, 辻内 俊文, 福嶋 伸之, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 2P, 0682,   2010 12
  • LPA3受容体活性化は海馬神経細胞の軸索分岐形成を引き起こす(Lysophosphatidic acid receptor 3 activation induces axonal branch formation in cultured hippocampal neurons), 福嶋 伸之, 古田 大祐, 山根 昌之, 辻内 俊文, 森山 隆太郎, 神経化学, 49, 2-3, 540, 540,   2010 08
  • 培養海馬ニューロンにおいてリゾホスファチジン酸受容体3は神経突起分枝と関係がある(Lysophosphatidic acid receptor 3 is involved in neurite branching formation in cultured hippocampal neurons), 古田 大祐, 山根 昌之, 森山 隆太郎, 辻内 俊文, 福嶋 伸之, 日本生化学会大会プログラム・講演要旨集, 82回, 4P, 415,   2009 09