KINDAI UNIVERSITY


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YAMADA Yasue

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FacultyDepartment of Biotechnology and Chemistry / Graduate School of System Enginnering / Research Institute of Fundamental Technology for Next Generation
PositionProfessor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/835-yamada-yasue.html
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Last Updated :2020/09/30

Education and Career

Academic & Professional Experience

  •   2009 ,  - 現在, Faculty of Engineering, Kindai University

Research Activities

Research Areas

  • Life sciences, Pharmacology
  • Life sciences, Neuroscience - general
  • Life sciences, Anesthesiology
  • Life sciences, Functional biochemistry
  • Life sciences, Cardiology
  • Life sciences, Medical systems

Research Interests

  • PSD-95, PKC, MALS-2, Xenopus oocyte, GKAP, MAGUKs, Xenopus oocytes, PDZ domain, SAP102, PDZ, src, PDZ protein, oocyte

Published Papers

  • Physiological Activities of Perilla Frutescens Var. Frutescens Leaf Extracts and Storage Stability in Kneaded Noodles Food Science and Nutrition Studies, Yoshiyuki Watanabe, Hiroko Kitayama, Mina Yamamoto, Yasue Yamada, Masato Nomura, Food Science and Nutrition Studies, Food Science and Nutrition Studies, 2(2), 2018 , Refereed
  • 嗜好品によるカプサイシン受容体の作用, Yasue Yamada, AROMA RESEARCH, AROMA RESEARCH, 18(1), 48 - 51, 2017 , Refereed
  • Direct activation of GABAA receptors by substances in the organic acid fraction of Japanese sake., Izu H, Shigemori K, Eguchi M, Kawane S, Fujii S, KitamuraY, Aoshima H, YamadaY, Food Chemistry, Food Chemistry, 214, 354 - 359, Jul. 2016 , Refereed
  • Effects of fragrant compounds including in sake and shochu on neuronal receptors, AROMA RESEARCH, AROMA RESEARCH, 16(1), 66 - 73, 2015 , Refereed
  • Beneficial effects of fragrant compounds including in sake and shochu, AROMA RESEARCH, AROMA RESEARCH, 16(1), 3 - 8, 2015 , Refereed
  • Effect of volatile chemicals on neural cells, 46, 1 - 5, Dec. 2012
  • Effects of pyrroloquinoline quinone and imidazole pyrroloquinoline on biological activities and neural functions, Yasue Yamada, Kazuya Nishii, Koji Kuwata, Masashi Nakamichi, Kei Nakanishi, Atsushi Sugimoto, Kazuto Ikemoto, Heliyon, Heliyon, 6(1), e03240 - e03240, Jan. 2020 , Refereed
  • Comparison of the neurotoxicities between volatile organic compounds and fragrant organic compounds on human neuroblastoma SK-N-SH cells and primary cultured rat neurons, Yasue Yamada, Kohei Ohtani, Akinori Imajo, Hanae Izu, Hitomi Nakamura, Kohei Shiraishi, Toxicology Reports, Toxicology Reports, 2, 729 - 736, Jan. 01 2015 , Refereed
    Summary:These are many volatile organic compounds (VOCs) that are synthesized, produced from petroleum or derived from natural compounds, mostly plants. Fragrant and volatile organic compounds from plants have been used as food additives, medicines and aromatherapy. Several clinical and pathological studies have shown that chronic abuse of VOCs, mainly toluene, causes several neuropsychiatric disorders. Little is known about the mechanisms of neurotoxicity of the solvents. n-Octanal, nonanal, and 2-ethyl-1-hexanol, which are used catalyzers or intermediates of chemical reactions, are released into the environment. Essential oils have the functions of self-defense, sterilization, and antibiosis in plants. When volatile organic compounds enter the body, there is the possibility that they will pass through the blood-brain barrier (BBB) and affect the central nervous system (CNS). However, the direct effects of volatile organic compounds on neural function and their toxicities are still unclear. We compared the toxicities of n-octanal, nonanal and 2-ethyl-1-hexanol with those of five naturally derived fragrant organic compounds (FOCs), linalool, cis-3-hexen-1-ol, isoamyl alcohol, n-propyl alcohol and n-phenethyl alcohol. MTT assay of human neuroblastoma SK-N-SH cells showed that the IC< inf> 50< /inf> values of linalool, cis-3-hexen-1-ol, isoamyl alcohol, n-propyl alcohol and phenethyl alcohol were 1.33, 2.3, > 5, > 5, and 2.39mM, respectively, and the IC< inf> 50< /inf> values of toluene, n-octanal, nonanal and 2-ethyl-1-hexanol were 850, 37.2, 8.31 and 15.1μM, respectively. FOCs showed lower toxicities than those of VOCs. These results indicate that FOCs are safer than other compounds.
  • Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins, T Iwamoto, Y Yamada, K Hori, Y Watanabe, K Sobue, M Inui, JOURNAL OF NEUROCHEMISTRY, JOURNAL OF NEUROCHEMISTRY, 89(1), 100 - 108, Apr. 2004
    Summary:The PSD-95/Dlg/ZO-1 (PDZ) domain-containing proteins MALS and PSD-95 localize to post-synaptic densities and bind the COOH-termini of NR2 subunits of the NMDA receptor. The effects of MALS-2 and PSD-95 on the channel activity of NMDA receptors were compared using the Xenopus oocyte expression system. Both MALS-2 and PSD-95 increased the current response of the NR1-NR2B receptor to L-glutamate. In contrast, the current response of the NR1-NR2A receptor was increased by PSD-95 but not by MALS-2. MALS-2 had no effect either on the potentiation of NR1-NR2A or NR1-NR2B channel activity by protein kinase C, or on Src-mediated potentiation of NR1-NR2A activity, whereas PSD-95 almost completely inhibited the effects of these protein kinases. Construction of chimeras of MALS-2 and PSD-95 revealed that the first two PDZ domains and two NH2-terminal cysteine residues are essential for the inhibitory effects of PSD-95 on protein kinase C-mediated potentiation of NR1-NR2A and NR1-NR2B channel activity, respectively. The second of the three PDZ domains of PSD-95 was required for its inhibition of Src-mediated potentiation of NR1-NR2A activity. These results indicate that the NR1-NR2A and NR1-NR2B receptors are modulated differentially by MALS-2 and PSD-95, and that similar regulatory effects of PSD-95 on these receptors are achieved by distinct mechanisms.
  • PSD-95 eliminates Src-induced potentiation of NR1/NR2A-subtype NMDA receptor channels and reduces high-affinity zinc inhibition, Y Yamada, T Iwamoto, Y Watanabe, K Sobue, M Inui, JOURNAL OF NEUROCHEMISTRY, JOURNAL OF NEUROCHEMISTRY, 81(4), 758 - 764, May 2002
    Summary:The channel activity of NMDA receptors is regulated by phosphorylation by protein kinases and by interaction with other proteins. Recombinant NR1/NR2A subtype NMDA receptor channels are potentiated by the protein tyrosine kinase Src, an effect which is mediated by a reduction in the high-affinity, voltage-independent Zn2+ inhibition. However, it has been reported that Src-induced potentiation of NMDA receptor currents in hippocampus neurons is not mediated by a reduction in Zn2+ inhibition. The post-synaptic density protein PSD-95 interacts with the C-terminus of NR2 subunits of the NMDA receptor. Here we demonstrate that PSD-95 eliminates the Src-induced potentiation of NR1/NR2A channels expressed in oocytes and reduces the sensitivity of the channels to Zn2+ . Our results reveal that the absence of Src-induced potentiation of PSD-95-coupled NR1/NR2A channels is not to due to the reduced sensitivity of these channels to Zn2+ . These results indicate that PSD-95 functionally modulates NR1/NR2A channels and explain why Src-induced potentiation of NMDA receptor currents in hippocampus neurons is not mediated by a reduction in Zn2+ inhibition.
  • Activation of channel activity of the NMDA receptor-PSD-95 complex by guanylate kinase-associated protein (GKAP), Y Yamada, Y Chochi, JA Ko, K Sobue, M Inui, FEBS LETTERS, FEBS LETTERS, 458(3), 295 - 298, Sep. 1999 , Refereed
    Summary:The channel-associated protein PSD-95 functionally modulates NMDA receptor channels, interacting,vith the channels via PDZ domain of PSD-95, PSD-95 also interacts with guanylate kinase-associated protein (GKAP) through the guanylate kinase-like domain of PSD-95. Here we report that GKAP markedly potentiates the channel activity of the receptor-PSD-95 complex. However, GKAP had no effect on basic properties of the channels nor on PSD-95-induced changes in channel properties. Thus, GKAP affects the channel activity of the NMDA receptor via PSD-95 quantitatively,,which may make signal transmission more efficient at postsynaptic sites. (C) 1999 Federation of European Biochemical Societies.
  • Modulation of the channel activity of the epsilon 2/zeta 1-subtype N-methyl D-Aspartate receptor by PSD-95, Y Yamada, Y Chochi, K Takamiya, K Sobue, R Inui, JOURNAL OF BIOLOGICAL CHEMISTRY, JOURNAL OF BIOLOGICAL CHEMISTRY, 274(10), 6647 - 6652, Mar. 1999 , Refereed
    Summary:A channel-associated protein PSD-95 has been shown to induce clustering of N-methyl D-aspartate (NMDA) receptors, interacting with the COOH terminus of the epsilon subunit of the receptors. The effects of PSD-95 on the channel activity of the epsilon 2/zeta 1 heteromeric NMDA receptor were examined by injection of PSD-95 cRNA into Xenopus oocytes expressing the NMDA receptors. Expression of PSD-95 decreased the sensitivity of the NMDA receptor channels to L-glutamate. Mutational studies showed that the interaction between the COOH terminus of the epsilon 2 subunit of the NMDA receptor and the second PSD-95/Dlg/Z0-1 domain of PSD-95 is critical for the decrease in glutamate sensitivity. It is known that protein kinase C markedly potentiates the channel activity of the MMDA receptor expressed in oocytes. PSD-95 inhibited the protein kinase C-mediated potentiation of the channels. Thus, we demonstrated that PSD-95 functionally modulates the channel activity of the epsilon 2/zeta 1 NMDA receptor. PSD-95 makes signal transmission more efficient by clustering the channels at postsynaptic sites. In addition to this, our results suggest that PSD-95 plays a protective role against neuronal excitotoxicity by decreasing the glutamate sensitivity of the channels and by inhibiting the protein kinase C mediated potentiation of the channels.
  • Distribution and developmental changes of adenylate kinase isozymes in the rat brain: Localization of adenylate kinase 1 in the olfactory bulb, Sachiye Inouye, Yasue Yamada, Koshiro Miura, Haruko Suzuki, Keisuke Kawata, Koh Shinoda, Atsushi Nakazawa, Biochemical and Biophysical Research Communications, Biochemical and Biophysical Research Communications, 254(3), 618 - 622, Jan. 27 1999 , Refereed
    Summary:Changes in the levels of three adenylate kinase isozymes (AK1, AK2, and AK3) in the rat brain during development were investigated by immunoblot analysis. The levels of AK1 and AK3 of the whole brain increased after birth, while AK2 was detected only in the early embryonic period. In the adult rat brain, high levels of AK1 were present in the olfactory bulb. Immunohistochemical analysis showed that AK1 was found predominantly in the olfactory nerve layer and the glomerular layer. In the olfactory bulb, AK1 gene expression was enhanced in the early postnatal days, whereas it remained low in the cerebellum during the first 10 postnatal days. These results suggest that the AK isozymes are involved in neuronal maturation and regeneration. The understanding of the physiological actions of adenosine and ATP as neurotransmitters/neuromodulaters in the central nervous system has improved. ATP and adenosine receptors have been found to be widely distributed over the whole brain, although the intra- and extracellular metabolism of these compounds has not been well elucidated.
  • Increase of adenylate kinase isozyme 1 protein during neuronal differentiation in mouse embryonal carcinoma P19 cells and in rat brain primary cultured cells, Sachiye Inouye, Misuzu Seo, Yasue Yamada, Atsushi Nakazawa, Journal of Neurochemistry, Journal of Neurochemistry, 71(1), 125 - 133, Jul. 1998 , Refereed
    Summary:Adenylate kinase (AK), which catalyzes the equilibrium reaction among AMP, ADP, and ATP, is considered to participate in the homeostasis of energy metabolism in cells. Among three vertebrate isozymes, AK isozyme 1 (AK1) is present prominently in the cytosol of skeletal muscle and brain. When mouse embryonal carcinoma P19 cells were differentiated by retinoic acid into neural cells, the amount of AK1 protein and enzyme activity increased about fivefold concomitantly with neurofilament (NF). Double-immunofluorescence staining showed that both AK1 and NF were located in neuronal processes as well as the perinuclear regions in neuron-like cells, but not in glia-like cells. The amount of brain-type creatine kinase increased only twofold during P19 differentiation. The AK isozyme 2, which was not detected in adult mouse brain, was found in P19 cells and did not increase during the differentiation. Mitochondrial AK isozyme 3, which uses GTP instead of ATP as a phosphate donor, was increased significantly. Immunohistochemical analysis with the primary cultured cells from rat cerebral cortex showed similar cellular localization of AK1 to those observed with differentiated P19 cells. These results suggest an important role of this enzyme in neuronal functions and in neuronal differentiation.
  • Characterization of the gntT gene encoding a high-affinity gluconate permease in Escherichia coli, H Izu, T Kawai, Y Yamada, H Aoshima, O Adachi, M Yamada, 199(1-2), 203 - 210, Oct. 1997 , Refereed
  • Pb2+ reduces the current from NMDA receptors expressed in Xenopus oocytes, Yasue Yamada, Hisamitsu Ujihara, Hideaki Sada, Takashi Ban, FEBS Letters, FEBS Letters, 377(3), 390 - 392, Dec. 27 1995 , Refereed
    Summary:We compared the effects of Pb2+ on four types of NMDA receptors expressed in Xenopus ooeytes. Pb2+ reduced the currents evoked by glutamate and glycine. The Ki values of the receptors, ε1/ζ1, ε2/ζ1, ε3/ζ1 and ε4/ζ1, were 39, 34, 54 and 42 μM, respectively, and their Hill coefficients were 0.53, 4.6, 0.52 and 0.37, respectively. The ε2/ζ1 receptor that was inhibited in the presence of over 30 μM Pb2+ was not recovered to the control level after a Pb2+ washout for over 30 min, suggesting that ε2/ζ1 is responsible for the chronic Pb2+ intoxication in the nervous system. © 1995 Federation of European Biochemical Societies. All rights reserved.
  • A ColE1-encoded gene directs entry exclusion of the plasmid, Y. Yamada, M. Yamada, A. Nakazawa, Journal of Bacteriology, Journal of Bacteriology, 177(21), 6064 - 6068, 1995 , Refereed
    Summary:To detect entry exclusion of the ColE1 plasmid, we established an assay system that was not influenced by incompatibility of extant plasmids in the recipient cells or by the viability of the cells due to the killing action of colicin E1 protein. The assay revealed that exc1 and exc2, assigned as genes directing entry exclusion, had no exclusion activity. Instead, mbeD, which had been characterized as a gene for plasmid mobilization, directed the exclusion activity. MbeD was overexpressed and identified as a 35S-labeled protein, which was recovered in both the soluble and membrane fractions, particularly in the inner membrane fraction. An amphipathic helical structure was predicted in the N-terminal region of MbeD as well as in the corresponding homologous proteins of ColA and ColK. These proteins may bind to the inner membrane via the N-terminal amphipathic helix and function in entry exclusion.
  • Topological analysis of quinoprotein glucose dehydrogenase in Escherichia coli and its ubiquinone-binding site, M Yamada, K Sumi, K Matsushita, O Adachi, Y Yamada, Journal of Biological Chemistry, Journal of Biological Chemistry, 268(17), 12812 - 12817, Jun. 15 1993 , Refereed
  • Biological and biochemical characteristics of murine megakaryoblastic cell line L8057, Y Ishida, J Levin, G Baker, P E Stenberg, Y Yamada, H Sasaki, T Inoue, Experimental Hematology, Experimental Hematology, 21(2), 289 - 298, Feb. 1993 , Refereed
  • Characterization of the gcd gene from Escherichia coli K-12 W3110 and regulation of its expression, M Yamada, S Asaoka, M, H Saier Jr, Y Yamada, Journal of Bacteriology, Journal of Bacteriology, 175(2), 568 - 571, Jan. 1993 , Refereed
  • Insertion of the mannitol permease into the membrane of Escherichia coli. Possible involvement of an N-terminal amphiphilic sequence, Y Yamada, Y Y Chang, G A Daniels, L F Wu, J M Tomich, M Yamada, M H Saier J, Journal of Biological Chemistry, Journal of Biological Chemistry, 266(27), 17863 - 17871, Sep. 1991 , Refereed
  • Biological effects of recombinant erythropoietin, granulocyte-macrophage colony-stimulating factor, interleukin 3, and interleukin 6 on purified rat megakaryocytes, Y Ishida, S Yano, T Yoshida, H Tanaka, Y Yamada, M Kawano, T Kaneko, N Matsumoto, Experimental Hematology, Experimental Hematology, 19(7), 608 - 612, Aug. 1991 , Refereed
  • Nucleotide sequence and expression of the gutQ gene within the glucitol operon of Escherichia coli, M Yamada, Y Yamada, M H Saier J, DNA sequence, DNA sequence, 1(2), 141 - 145, 1990 , Refereed
  • Characterization of hemolysin in extracellular products of Pseudomonas cepacia, T Nakazawa, Y Yamada, M Ishibashi, Journal of Clinical Microbiology, Journal of Clinical Microbiology, 25(2), 195 - 198, Feb. 1987 , Refereed
  • Membrane-bound, electron transport-linked, D-glucose dehydrogenase of Pseudomomas fluorecens. Interaction of the purified enzyme with ubiquinone or phospholiplid., Matsushita K, Yamada Y, Ohno Y, Shinagawa E, Adachi O, Ameyama M, Agricultural Biological Chemistry, Agricultural Biological Chemistry, 46(6), 1007 - 1011, 1982 , Refereed
  • Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria, M Ameyama, K Matsushita, Y Ohno, E Shinagawa, O Adachi, FEBS Letters, FEBS Letters, 130(2), 179 - 183, Aug. 1981 , Refereed
  • Membrane-bound D-glucose dehydrogenase from Pseudumonas sp.: Solubilization, purification and characterization, Matsushita K, Ohno Y, Shinagawa E, Adachi O, Ameyama M, Agricultural Biological Chemistry, Agricultural Biological Chemistry, 44(7), 1505, 1980 , Refereed

Books etc

  • Advances In Chemistry Research Volume 34, Yasue Yamada, Joint author, Chapter 3 Neurological Activities of Linalool and Other Fragrant Compounds, Nova Science Publishers,   2017 01

Conference Activities & Talks

  • New modulators of capsaicine receptor TRPV1 in fermented foods, Yasue Yamada,   2019 08
  • Comparison of the biological effects of pyrroloquinoline quinone and imidazole pyrroloquinoline, Yasue Yamada, Kazuya Nishii, Atsushi Sugimoto, Kazuto. Ikemoto, European Congress on Biotechnology,   2018 07
  • Effect of amines on GluN1/GluN2A and GluN1/GluN2B subtypes of NMDA receptor., Y Yamada,T Yabuki, K Nishii, Society for Neuroscience 47th Annual Meeting 2017,   2017 11
  • The effect of an organophosphorus agent on human neuroblastomaagent cell line SK-N-SH., Y. Yamada, H. Shiraishi, A. Nameda, Y. Arima, M. Nagao, Society for Neuroscience 46th Annual Meeting 2016,   2016 10
  • Protective effects of PQQ against the cell death caused by 6-hydroxydopamine and hydrogen peroxide., Y. Yamada, M. Nakamichi, Society for Neuroscience 45th Annual Meeting,   2015
  • “GABAA receptor agonist activity and anxiolytic effects of organic acids, Y. Yamada, K. Shigemori, M Eguchi, S. Kawane, H. Izu, Society for Neuroscience 44th Annual Meeting (2014) Washington D.C.,   2014 11
  • The effect of a sarin-like organophosphorus agent on human neuroblastoma cell line SK-N-SH, K. Yamada, H. Shiraishi, A. Namera, Y. ArimaM. Nagao, Y, Yamada,   2014 10
  • The beneficial effect of propolis on fat accumulation and lipid metabolism in NASH model,   2014
  • Effects of polyamines and monoamines on GluN1/GluN2A and GluN1/GluN2B subtypes of NMDA receptor, Y. Yamada, K. Norikane, K. Matsumaru, H. Izu, Neuroscience 2013,   2013 11
  • Effects of various fragrant compounds on GluN1/GluN2A and GluN1/GluN2B subtypes of NMDA receptor., Neuroscience 2012,   2012 10 , Neuroscience 2012
  • Effects of deipeptides on NMDA type glutamate receptors,   2011 03
  • Modulation of the channel activity of NR1/NR2A-and NR1/NR2B-subtype NMDA receptor by MAGUKs family protein, SAP102., Yasue Yamada, Makoto Inui, Soceity for Neuroscience 2010,   2010 11 , Soceity for Neuroscience 2010
  • Glutamate receptor and dipeptides,   2010 02
  • PSD-95 modulate the sensitivity of Nr1/NR2A subtype receptor channels for a NMDA receptor antagonist, MK-801.
  • Comparison of the effects of PSD-95 and MALS-2 on the channel activity of the NR1/NR2B-subtype NMDA receptor
  • Subtype-specific modulation of the channel activity of the NMDA receptor by PSD-95 and GKAP., Yasue Yamada, Makoto Inui, Society for Neuroscience annual meeting 2009

Misc

  • Anxiolytic Effect of Drinking Japanese Sake Assessed by the Elevated Plus-Maze Test in Mice, IZU Hanae, YAMADA Yasue, GOTO Kuniyasu, SUDO Shigetoshi, Journal of the Brewing Society of Japan, 105, 10, 664, 671,   2010 10 15 , 10.6013/jbrewsocjapan.105.664, http://ci.nii.ac.jp/naid/10027494565
  • PSD-95 modulates the sensitivity of NR1/NR2A subtype NMDA receptor channels for a NMDA receptor antagonist, MK801, Yasue Yamada, Makoto Inui, NEUROSCIENCE RESEARCH, 58, S187, S187,   2007
  • Modulation of NR1/NR2A-subtype NMDA receptor channels by SAP102, Y Yamada, M Inui, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 242P, 242P,   2006
  • Modulation of NR1/NR2B-subtype NMDA receptor channels by SAP-102, Y Yamada, M Inui, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 259P, 259P,   2005
  • Subtype-specific modulation of the channel activity of the NMDA receptor by PSD-95 and GKAP, Y Yamada, M Inui, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 223P, 223P,   2004
  • PSD-95 modulates NR1/NR2A-and NR1/NR2B-subtype receptor channels in different manners., Y Yamada, T Iwamoto, M Inui, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 236P, 236P,   2003
  • Effects of PSD-95 on NR1/NR2C and NR1/NR2D NMDA receptors, Y Yamada, T Iwamoto, M Inui, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 151P, 151P,   2002