KINDAI UNIVERSITY


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HIDAKA Yuji

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FacultyDepartment of Life Science / Graduate School of Science and Engineering Research
PositionProfessor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/400-hidaka-yuuji.html
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Last Updated :2020/04/07

Education and Career

Academic & Professional Experience

  •   2011 ,  - 現在, Faculty of Science and Engineering, Kindai University

Research Activities

Research Areas

  • Nanotechnology/Materials, Molecular biochemistry
  • Life sciences, Structural biochemistry

Published Papers

  • Tsubasa Tagawa, Teruki Hagiwara, Shigeru Shimamoto, and Yuji Hidaka, 2018, 101 - 101, Mar. 2019 , Refereed
  • STRUCTURAL CONTROL AND FUNCTIONAL ANALYSIS OF THE PRECURSOR PROTEIN OF ATRIAL NATRIURETIC PEPTIDE, Hayato Ueda, Shigeru Shimamoto, Yuji HidakaHayato Ueda, Shigeru Shimamoto, Yuji Hidaka, 2018, 94 - 94, Mar. 2019 , Refereed
  • STRUCTURAL ANALYSES OF AN N-TERMINAL EXTRACELLULAR DOMAIN OF THE AMYLOID PRECURSOR PROTEIN, 2018, 23 - 23, Mar. 2019 , Refereed
  • Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding, Okada S, Matsusaki M, Arai K, Hidaka Y, Inaba K, Okumura M, Muraoka T, Chem Commun (Camb), Chem Commun (Camb), 55(6), 759 - 762, Jan. 2019 , Refereed
  • Disulfide-Coupled Folding of Pro-Uroguanylin on Molecular Evolution, Kenta Mori, Kosuke Toyama, Saya Nishihara, Shigeru Shimamoto, Yuji Hidaka, 2017, 214 - 215, Mar. 2018 , Refereed
  • Molecular Evolution of L-PGDS:Substrate Recognition Mechanism of Medaka L-PGDS, Kimi Torii, Takahiro Maruno, Yuji Kobayashi, Yuji Hidaka, Shigeru Shimamoto, Peptide Science, Peptide Science, 2017, 210 - 211, Mar. 2018 , Refereed
  • Regulation of Disulfide-Coupled Folding of a De Novo Designed Protein, Saya Nishihara, Kosuke Toyama, Kenta Mori, Shigeru Shimamoto, Yuji Hidaka, Peptide Science, Peptide Science, 2017, 208 - 209, Mar. 2018 , Refereed
  • Structural Analyses of a Linker Region of the Amyloid Precursor Protein, Mizuho Imamura, Shingo Kanemura, Masaki Okumura, Hiroshi Yamaguchi, Shigeru Shimamoto, Yuji Hidaka, Peptide Science, Peptide Science, 2017, 206 - 207, Mar. 2018 , Refereed
  • Preparation of an Orexin Precorsor Protein Using an E. coli Expression System by Acid Treatment, Natsumi Mitsuoka, Shigeru Shimamoto, Yuji Hidaka, Peptide Science, Peptide Science, 2016, 221 - 222, Mar. 2017 , Refereed
  • Regulation of the Disulfide-Coupled Folding of De Novo Designed Peptides by alpha-Helix Formation, Saya Nishihara, Kosuke Toyama, Shigeru Shimamoto, Yuji Hidaka, Peptide Science, Peptide Science, 2016, 233 - 234, Mar. 2017 , Refereed
  • Activation Mechanism of Cocoonase, Nagisa Tajima, Shigeru Shimamoto, Mitsuhiro Miyazawa, Yuji Hidaka, Peptide SCience, Peptide SCience, 2016, 105 - 106, Mar. 2017 , Refereed
  • Disulfide-Coupled Folding of Pro-Uroguanylin on Molecular Evolution, Kenta Mori, Kosuke Toyama, Shigeru Shimamoto, Yuji Hidaka, Peptide Science, Peptide Science, 2016, 103 - 104, Mar. 2017 , Refereed
  • An alpha,beta-structural Shift of the Mature Region in a Precursor Protein Regulates Disulfide Selectivity under Kinetic Control, Kosuke Toyama, Shigeru Shimamoto, Yuji Hidaka, Peptide Science, Peptide Science, 2015, 333 - 334, Mar. 2016 , Refereed
  • a Mis-bridged Disulfide Isomer of Prouroguanylin, Kenta Hattori, Masaki Okumura, Shigeru Shimamoto, Yuji Hidaka, Peptide Science, Peptide Science, 2015, 327 - 328, Mar. 2016 , Refereed
  • Trapping Mechanism of Bioactive Conformation by Intra-molecular Chaperone, Yukihito Yokoyama, Masaki Okumura, Shigeru Shimamoto, Hiroshi Yamaguchi, Yuji Hidaka, Peptide Science, Peptide Science, 2014, 95 - 96, Mar. 2015 , Refereed
  • Inhibition of the Functional Interplay between Endoplasmic Reticulum (ER) Oxidoreduclin-1 alpha (Ero1 alpha) and Protein-disulfide Isomerase (PDI) by the Endocrine Disruptor Bisphenol A, Masaki Okumura, Hiroshi Kadokura, Shoko Hashimoto, Katsuhide Yutani, Shingo Kanemura, Takaaki Hikima, Yuji Hidaka, Len Ito, Kohei Shiba, Shoji Masui, Daiki Imai, Susumu Imaoka, Hiroshi Yamaguchi, Kenji Inaba, JOURNAL OF BIOLOGICAL CHEMISTRY, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(39), 27004 - 27018, Sep. 2014 , Refereed
    Summary:Bisphenol A (BPA) is an endocrine disruptor that may have adverse effects on human health. We recently isolated protein-disulfide isomerase (PDI) as a BPA-binding protein from rat brain homogenates and found that BPA markedly inhibited PDI activity. To elucidate mechanisms of this inhibition, detailed structural, biophysical, and functional analyses of PDI were performed in the presence of BPA. BPA binding to PDI induced significant rearrangement of the N-terminal thioredoxin domain of PDI, resulting in more compact overall structure. This conformational change led to closure of the substrate-binding pocket in b' domain, preventing PDI from binding to unfolded proteins. The b' domain also plays an essential role in the interplay between PDI and ER oxidoreduclin 1 alpha (Ero1 alpha), a flavoenzyme responsible for reoxidation of PDI. We show that BPA inhibited Ero1 alpha-catalyzed PDI oxidation presumably by inhibiting the interaction between the b' domain of PDI and Ero1 alpha; the phenol groups of BPA probably compete with a highly conserved tryptophan residue, located in the protruding beta-hairpin of Ero1 alpha, for binding to PDI. Consistently, BPA slowed down the reoxidation of PDI and caused the reduction of PDI in HeLa cells, indicating that BPA has a great impact on the redox homeostasis of PDI within cells. However, BPA had no effect on the interaction between PDI and peroxiredoxin-4 (Prx4), another PDI family oxidase, suggesting that the interaction between Prx4 and PDI is different from that of Ero1 alpha and PDI. These results indicate that BPA, a widely distributed and potentially harmful chemical, inhibits Ero1-PDI-mediated disulfide bond formation.
  • Overview of the regulation of disulfide bond formation in Peptide and protein folding., Yuji Hidaka, Current protocols in protein science, Current protocols in protein science, 76, 28.6.1 - 6, Apr. 2014 , Refereed
  • Chemical methods for producing disulfide bonds in peptides and proteins to study folding regulation., Okumura M, Shimamoto S, Hidaka Y, Current protocols in protein science, Current protocols in protein science, 76, 28.7.1 - 13, Apr. 2014 , Refereed
  • Chemical methods and approaches to the regioselective formation of multiple disulfide bonds., Shimamoto S, Katayama H, Okumura M, Hidaka Y, Current protocols in protein science, Current protocols in protein science, 76, 28.8.1 - 28, Apr. 2014 , Refereed
  • Folding of peptides and proteins: role of disulfide bonds, recent developments., Hidaka Y, Shimamoto S, Biomolecular concepts, Biomolecular concepts, 4(6), 597 - 604, Dec. 2013 , Refereed
  • Disulfide-coupled protein folding: Looking back, Looking forward, Yuji Hidaka, FEBS Journal, FEBS Journal, 279, 2261 - 2261, 2012 , Refereed
  • Chemical Method for investigating disulfide-coupled peptide and protein folding, Masaki Okumura, Shigeru Shimamoto, Yuji Hidaka, FEBS Journal, FEBS Journal, 279, 2283 - 2295, 2012 , Refereed
  • In vitro regulatory effect of epididymal serpin CRES on protease activity of Proprotein Convertase PC4/PCSK4, Priyambada Mishra, Qing Qiu, Andree Gruslin, Yuji Hidaka, Majambu Mbikay, Ajoy Basak, Current Molecular Medicine, Current Molecular Medicine, 12, 1050 - 1067, 2012 , Refereed
  • Effects of positively charged redox molecules on disulfide-coupled protein folding, Masaki Okumura, Shigeru Shimamoto, Yuji Hidaka, FEBS Lett, FEBS Lett, 586(21), 3926 - 3930, 2012 , Refereed
  • Stem-forming regions that are essential for the amyloidogenesis of prion proteins, Masatoshi Saiki, Yuji Hidaka, Masayuki Nara, Hisayuki Morii, Biochemistry, Biochemistry, 51, 1566 - 1576, 2012 , Refereed
  • Fiber Formation of a Synthetic Spider Peptide Derived from Nephila Clavata, Yuji Hidaka, Ko-Ichi Kontani, Rina Taniguchi, Masatoshi Saiki, Sayoko Yokoi, Kenji Yukuhiro, Hiroshi Yamaguchi, Mitsuhiro Miyazawa, Biopolymers, Biopolymers, 96(2), 222 - 227, 2011 , Refereed
  • Acceleration of Disulfide-Coupled Protein Folding Using Glutathione Derivatives, Masaki Okumura, Masatoshi Saiki, Hiroshi Yamaguchi, Yuji Hidaka, FEBS Journal, FEBS Journal, 278, 1134 - 1144, 2011 , Refereed
  • Recognition of the N-Terminal Histone H2A and H4 Peptides by Peptidylarginine Deiminase IV, Masatoshi Saiki, Mayumi Watase, Hironori Matsubayashi, Yuji Hidaka, Protein and Peptide Letters, Protein and Peptide Letters, 16, 1012 - 1016, Sep. 2009 , Refereed
  • Crystallization and Preliminary X-ray Structural Studies of Human Prouroguanylin, Len Ito, Yuji Hidaka (corresponding author, Masaki Okumura, Hironori Konishi, Adermann Knut, Hiroshi Yamaguchi, Acta Crystallogr. Sect F Struct Biol Cryst Commun., Acta Crystallogr. Sect F Struct Biol Cryst Commun., 64(8), 771 - 772, Jun. 2008 , Refereed
  • Structural Basis for Substrate Recognition and Dissociation by Human Transportin 1, Tsuyoshi Imasaki, Toshiyuki Shimizu, Hiroshi Hashimoto, Yuji Hidaka, Shingo Kose, Naoko Imamoto, Michiyuki Yamada, Mamoru Sato, Mol Cell, Mol Cell, 28(1), 57 - 67, Oct. 2007 , Refereed
  • Structural Basis for Histone N-terminal Recognition by Peptidylarginine Deiminase 4, Kyouhei Arita, Toshiyuki Shimizu, Hiroshi Hashimoto, Yuji Hidaka, Michiyuki Yamada, Mamoru Sato, Proc. Natl. Acad. Sci. (U.S.A.), Proc. Natl. Acad. Sci. (U.S.A.), 103(14), 5291 - 5296, Apr. 2006 , Refereed
  • Deimination of Histone H2A and H4 at Arginine 3 in HL-60 Granulocytes, Teruki Hagiwara, Yuji Hidaka, Michiyuki Yamada, Biochemistry, Biochemistry, 44, 5827 - 5834, Mar. 2005 , Refereed
  • Side Chain Contributions to the interconversion of the Topological Isomers of Guanylin-like Peptides, Journal of Peptide Science, Journal of Peptide Science, 11, 319 - 330, 2005 , Refereed
  • Methylation of the Guanidino Group of Arginine Residues Prevents Citrullination by, Teruki Hagiwara, Yuji Hidaka, Michiyuki Yamada, FEBS Letters, FEBS Letters, 579, 4088 - 4092, 2005 , Refereed
  • Side Chain Contributions to the Interconversion of the Topological Isomers of Guanylin-like Peptides, Axel Schulz, Ute Marx, Naomi Tidten, Thomas Lauber, Yuji Hidaka, Knut Adermann, Journal of Peptide Science, Journal of Peptide Science, 11, 319 - 330, Nov. 2004 , Refereed
  • Role of Disulfide Bonds in the Folding of Prouroguanylin and Heat-stable Enterotoxin, Yuji Hidaka, Len Ito, Hiroshi Yamaguchi, Peptides Revolution: Genomics, Proteomics & Therapeutics, Peptides Revolution: Genomics, Proteomics & Therapeutics, 2003, 431 - 432, Mar. 2004 , Refereed
  • Folding of a Peptide Hormone Assisted by a Propeptide: Folding of Hybrid Disulfide Isomers of Uroguanylin and Heat-stable Enterotoxin, Yuji Hidaka, Len Ito, Kaori Segawa, Hiroshi Yamaguchi, Peptide Science, Peptide Science, 2003(2003), 103 - 106, 2004 , Refereed
  • The Micro Domain Responsible for Ligand-binding of Guanylyl Cyclase C, Yuji Hidaka, Yoshiko Matsumoto, Yasutsugu Shimonishi, FEBS Lett, FEBS Lett, 526, 58 - 62, Jul. 2002 , Refereed
  • Dual Function of the Propeptide of Prouroguanylin in the Folding of the Mature Peptide: Disulfide-coupled Folding and Dimerization, Yuji Hidaka, Chisei Shimono, Megumu Ohno, Nobuaki Okumura, Knut Adermann, Wolf-Georg Forssmann, Yasutsugu Shimonishi, J. Biol. Chem., J. Biol. Chem., 275, 25155 - 25162, Aug. 2000 , Refereed
  • Determination of the Binding Site on the Extracellular Domain of Guanylyl Cyclase C to Heat-stable Enterotoxin, Makoto Hasegawa, Yuji Hidaka, Yoshiko Matsumoto, Toshifumi Sanni, Yasutsugu Shimonishi, J. Biol. Chem, J. Biol. Chem, 274, 31713 - 31718, Oct. 1999 , Refereed
  • Role of the Prosequence of Guanylin, Axel Schulz, Ute C. Marx, Yuji Hidaka, Yasutsugu Shimonishi, Paul Rosch, Wolf-Georg Forssmann, Knut Adermann, Protein Science, Protein Science, 8, 1850 - 1859, Aug. 1999 , Refereed
  • The relevance of N-linked glycosylation to the binding of a ligand to guanylate cyclase C, Makoto Hasegawa, Yuji Hidaka, Akihiro Wada, Toshiya Hirayama, Yasutsugu Shimonishi, Eur. J. Biochem, Eur. J. Biochem, 263, 338 - 345, Jul. 1999 , Refereed
  • Expression and characterization of the extracellular domain of guanylyl cyclase C from a bacurovirus and Sf21 insect cells, Makoto Hasegawa, Yuki Kawano, Yoshiko Matsumoto, Yuji Hidaka, Jun-ichi Fuji, Naoyuki Taniguchi, Akihiro Wada, Toshiya Hirayama, Yasutsugu Shimonishi, Protein Expression and Purification,, Protein Expression and Purification,, 15, 271 - 281, Mar. 1999 , Refereed
  • Unique synthetic peptides stimulating streptolysin S production in Streptococci, Teruaki Akao, Shuichi Hashimoto, Kyoichi Kobashi, Yuji Hidaka, J. Biochem, J. Biochem, 125, 27 - 30, Jan. 1999 , Refereed
  • In vitro disulfide-coupled folding of guanylyl cyclase-activating peptide and its precursor protein., Yuji Hidaka, Megumu Ohno, Bahram Hemmasi, Oliver Hill, Wolf-Georg Forssmann, Yasutsugu Shimonishi, Biochemistry, Biochemistry, 37, 8498 - 8507, May 1998 , Refereed
  • Nitrate reductase from pseudomonas aeruginosa induces inflammatory cytokines in cultured respiratory cells, Kazunori Oishi, Borann Sar, Akihiro Wada, Yuji Hidaka, Shigeru Matsumoto, Hideaki Amano, Fuminari Sonoda, Shinobu Kobayashi, Toshiya Hirayama, Tsuyoshi Nagatake, Kouji Matsushima, Infect. Immun., Infect. Immun., 65, 2648 - 2655, Jul. 1997 , Refereed
  • Identification of a binding region on Escherichia coli heat-stable enterotoxin to intestinal guanylyl cyclase C, Makoto Hasegawa, Yuki Kawano, Kazuya Matsumoto, Yuji Hidaka, Takashi Sato, Yasutsugu Shimonishi, Letters in Peptide Science, Letters in Peptide Science, 4, 1 - 11, Apr. 1997 , Refereed
  • Demonstration of dimer formation of the cytoplasmic domain of a transmembrane osmosensor protein, EnvZ, of escherichia coli using Ni-histidine tag affinity chromatography, Yuji Hidaka, Heiyoung Park, Masayori Inouye, FEBS Lett, FEBS Lett, 400, 238 - 242, Feb. 1997 , Refereed
  • Identification of ligand recognition sites in heat-stable enterotoxin receptor, membrane-associated guanylyl cyclase C by site directed mutational analysis, Akihiro Wada, Toshiya Hirayama, Hirotake Kitaura, Jun-ichi Fujisawa, Makoto Hasegawa, Yuji Hidaka, Yasutsugu Shimonishi, Infect. Immun, Infect. Immun, 64, 5144 - 5150, Dec. 1996 , Refereed
  • The significance of Ser1029 of the heat-stable enterotoxin receptor (STaR): relation of STa-mediated guanylyl cyclase activation and siganling by phorbol myristate acetate., Akihiro Wada, Makoto Hasegawa, Kazuya Matsumoto, Takuro Niidome, Yuki Kawano, Yuji Hidaka, Philip Ian Padilla, Hisao Kurazono, Yasutsugu Shimonishi, Toshiya Hirayama, FEBS Lett, FEBS Lett, 384, 75 - 77, Jun. 1996 , Refereed
  • Characterization of Carboxy-terminal Region of Heat-stable Enterotoxin Receptor (STaR), Wada, A, Padilla, P.I, Takamoto, T, Hasegawa, M, Matsumoto, K, Kawano, Y, Hidaka, Y, Kurazono, H, Shimonishi, Y, Hirayama, T, Japanese Journal of Medical Science & Biology, Japanese Journal of Medical Science & Biology, 49, 254 - 255, Mar. 1996 , Refereed
  • Novel motifs in extracellular domain of heat-stable enterotoxin receptor (STaR), Wada, A, Oshita, T, Kitaura, H, Hasegawa, M, Fujisawa, J, Hidaka, Y, Shimonishi, Y, Hirayama, T, Japanese Journal of Medical Science & Biology, Japanese Journal of Medical Science & Biology, 48, 266 - 267, Mar. 1995 , Refereed
  • Pig intestinal membrane-bound receptor (guanylyl cyclase) for heat-stable enterotoxin: cDNA cloning, functional expression, and characterization., Akihiro Wada, Toshiya Hirayama, Saori Kitao, Jun-ichi Fujisawa, Yuji Hidaka, Yasutsugu Shimonishi, Microbiol. Immunol., Microbiol. Immunol., 38, 535 - 541, Jul. 1994 , Refereed
  • Significant amino-acids of Heat-stable Enterotoxin Receptor (StaR) for STa-binding, Akihiro Wada, A, Oshita, T, Kitaura, H, Jun-ichi Fujisawa, Yuji Hidaka, Yasutsugu Shimonishi, Toshiya Hirayama, Japanese Journal of Medical Science & Biology, Japanese Journal of Medical Science & Biology, 47, 315 - 316, Apr. 1994 , Refereed
  • Structure of IgE epitopes on a new 39-kD allergen molecule from the house dust mite, Dermatophagoides farinae., Tsunehiro Aki, Kazuhisa Ono, Yuji Hidaka, Yasutsugu Shimonishi, Toshihiko Jyo, Takeshi Wada, Mitsuo Yamashita, Seiko Shigeta, Yoshikatsu Morooka, Satoru Oka, nternational Archives of Allergy and Immunology, nternational Archives of Allergy and Immunology, 103, 357 - 364, Apr. 1994 , Refereed
  • Expression of a Truncated Guanylate Cyclase (GC-C), a Receptor for Heat-Stable Enterotoxin of Enterotoxigenic Escherichia Coli, and its Dimer Formation in COS-7 Cells, Toshiya Hirayama, Akihiro Wada, Yuji Hidaka, Jun-ichi Fujisawa, Yoshifumi Takeda, Yasutsugu Shimonishi, Microbial Pathogenesis, Microbial Pathogenesis, 15, 283 - 291, Dec. 1993 , Refereed
  • High-Performance Liquid Chromatographic Determination of Neutral and Amino Monosaccharides by Ultraviolet and Fluorescence Detection of Sugar 9-Fluorenylmethoxycarbonyl Hydrazones and 9-Fluorenylmethoxycarbonyl Amino Sugars at Picomole and Sub-Picomole Le, Renen Zhang, Zhidan Zhang, Guoquan Liu, Yuji Hidaka, Yasutsugu Shimonishi, Journal of Chromatography,, Journal of Chromatography,, 646, 45 - 52, Mar. 1993 , Refereed
  • Identification and Cloning of the Pig Receptor for Escherichia Coli Heat-stable Enterotoxin (STa), Akihiko Wada, Toshiya Hirayama, Jun-ichi Fujisawa, Yuji Hidaka, Yasutsugu Shimonish, Japanese Journal of Medical Science & Biology, Japanese Journal of Medical Science & Biology, 45, 295 - 296, Apr. 1992 , Refereed
  • Synthesis and Biological Properties of Carba-Analogs of Heat-stable Enterotoxin (ST) Produced by Enterotoxigenic Escherichia Coli, Yuji Hidaka, Katsuhiko Ohmori, Akihiro Wada, Hiroshi Ozaki, Hideaki Ito, Toshiya Hirayama, Yoshifumi Takeda, Yasytsugu Shimonishi, Biochem. Biophys. Res. Commun, Biochem. Biophys. Res. Commun, 176, 958 - 965, May 1991 , Refereed
  • Conformation in Solution of the Fully Toxic Domain of Heat-Stable Enterotoxin (STp) Produced by Enterotoxigenic Escherichia Coli, Hiroshi Ozaki, Hirokazu Kubota, Takashi Sato, Yuji Hidaka, Haruhiko Tamaoki, Yuji Kobayashi, Yoshimasa Kyogoku, Takashi Sugimura, Akira Tai, Yasutsugu Shimonishi, Bull. Chem. Soc. Jpn, Bull. Chem. Soc. Jpn, 64, 1136 - 1144, Apr. 1991 , Refereed
  • Structure-Activity Relationship of Esherichia Coli Heat-Stable Enterotoxin : Role of Ala Residue at Position 14 in Toxin-Receptor Interaction, Shinji Yamasaki, Takashi Sato, Yuji Hidaka, Hiroshi Ozaki, Hideaki Ito, Toshiya Hirayama, Yoshifumi Takeda, Takashi Sugimura, Akira Tai, Yasutsugu Shimonishi, Bull. Chem. Soc. Jpn., Bull. Chem. Soc. Jpn., 53, 2063 - 2070, Jul. 1990 , Refereed
  • A New Method for Determination of Disulfide Pairing in Peptide, Yuji Hidaka, Yasutsugu Shimonishi, Bull. Chem. Soc. Jpn.,, Bull. Chem. Soc. Jpn.,, 62, 1986 - 1994, Jun. 1989 , Refereed
  • Structural Requirements for the Spatial Structure and Toxicity of Heat-Stable Enterotoxin (STh) of Enterotoxigenic Escherichia Coli, Shinji Yamasaki, Yuji Hidaka, Hideaki Ito, Yoshifumi Takeda, Yasutsugu Shimonishi, Bull. Chem. Soc. Jpn, Bull. Chem. Soc. Jpn, 61, 1701 - 1706, May 1988 , Refereed
  • Disulfide Linkages in a Heat-Stable Enterotoxin (STp) Produced by a Porcine Strain of Enterotoxigenic Escherichia Coli, Yuji Hidaka, Hirokazu Kubota, Shoko Yoshimura, Hideaki Ito, Yoshifumi Takeda, Yasutsugu Shimonishi, Bull. Chem. Soc. Jpn., Bull. Chem. Soc. Jpn., 61, 1265 - 1271, Apr. 1988 , Refereed
  • Structure-Activity Relationship of a Heat-stable Enterotoxin Produced by Yersinia Enterocolitica, Shoko Yoshimura, Yuji Hidaka, Saburo Aimoto, Yasutsugu Shimonishi, Tae Takeda, Toshio Miwatani, Yoshifumi Takeda, Bull. Chem. Soc. Jpn., Bull. Chem. Soc. Jpn., 60, 2481 - 2489, Jul. 1987 , Refereed

Conference Activities & Talks

  • Understanding the mechanism by which PDI family catalyze oxidative folding of precursor protein,   2019 09 20
  • Acceleration of oxidative protein folding by newly-developed redox molecules,   2019 09 20
  • Cloning and Functional Analysis of Digestive Enzyme Derived from N ephila Clavata, Tsubasa Tagawa, Teruki Hagiwara, Shigeru Shimamoto, Yuji Hidaka,   2018 12 07
  • Structural Control and Functional Analysis of the Precursor Protein of Atrial Natriuretic Peptide, HayatoUeda, Shigeru Shimamoto, Yuji Hidaka,   2018 12 06
  • Structural Analyses of an N-terminal Extracellular Domain of the Amyloid Precursor Protein, Mizuho Imamura, Shingo Kanemura, Masaki Okumura, Hiroshi Yamaguchi, Shigeru Shimamoto, Yuji Hidaka, 10th International Peptide Symposium,   2018 12 05
  • MOLECULAR RECOGNITION MECHANISM OF HEMATOPOIETIC PROSTAGLANDIND SYNTHASE WITH COFACTOR AND ITS SUBSTRATE, Shigeru Shimamoto, Keisuke Asada, Yuji Hidaka, 62th Annual Meeting of Biophysycal Society,   2018 02 21
  • ACTIVATION MECHANISM OF COCOONASE, Nagisa Tajima, Mitsuhiro Miyazawa, Shigeru Shimamoto, Yuji Hidaka, 62th Annual Meeting of Biophysycal Society,   2018 02 21
  • STRUCTURAL ANALYSES OF A LINKER REGION OF THE AMYLOID PRECURSOR PROTEIN, Mizuho Imamura, Shingo Kanemura, Masaki Okumura, Shigeru Shimamoto, Yuji Hidaka, 62th Annual Meeting of Biophysycal Society,   2018 02 18
  • FOLDING ANALYSES OF A DE NOVO DESIGNED PROUROGUANYLIN., Yuji Hidaka, Saya Nishihara, Kenta Mori, Shigeru Shimamoto, 62th Annual Meeting of Biophysical Society,   2018 02 18
  • DISULFIDE-COUPLED FOLDING OF PROUROGUANYLIN ON MOLECULAR EVOLUTION, Kenta Mori, Saya Nishihara, Shigeru Shimamoto, Yuji Hidaka, 62th Annual Meeting of Biophysical Society,   2018 02 18
  • MOLECULAR EVOLUTION OF L-PGDS: SUBSTRATE RECOGNITION MECHANISM, Kimi Torii, Yuji Hidaka, Shigeru Shimamoto, 62th Annual Meeting of Biophysical Society,   2018 02 18
  • Molecular evolution of L-PGDS: substrate recognittion mechanism of medaka L-PGDS, Kimi Torii, Takahiro Maruno, Yuji Kobayashi, Yuji Hidaka, Shigeru Shimamoto,   2017 11 20
  • Regulation of disulfide-coupled folding of a de novo designed protein, Saya Nishihara, Kosuke Toyama, Kenta Mori, Shigeru Shimamoto, Yuji Hidaka,   2017 11 20
  • Structural analyses of a linker region of the amyloid precursor protein, Mizuho Imamura, Shingo Kanemura, Masaki Okumura, Shigeru Shimamoto, Yuji Hidaka,   2017 11 20
  • Lipocalin-Type Prostaglandin D Synthase Possesses Two Binding Sites for its product., Shigeru Shimamoto, Yusuke Nakagawa, Yuta Nakahata, Takahiro Maruno, Yuji Kobayashi, Kosuke Aritake, Yoshihiro Urade, Yuji Hidaka, 61st Annual Meeting of Biophysical Scoiety,   2017 02 14
  • Molecular recognition mechanism of Hematopoietic Prostaglandin D Synthase with cofactor and its substrate, Keisuke Asada, Shigeru Shimamoto, Tomohiro Oonoki, Takahiro Maruno, Yuji Kobayashi, Kosuke Aritake, Yoshihiro Urade, Yuji Hidaka, 61st Annual Meeting of Biophysical Scoiety,   2017 02 14
  • Regulation of protein folding using organic solvents and ion liquid, Yuji Hidaka, Wataru Ito, Ryosuke, Nishimura, Shigeru Shimamoto, 61st Annual Meeting of Biophysical Scoiety,   2017 02 12
  • Structural analysis of the precursor protein of atrial natriuretic peptide, Sumika Futori, Satomi Higashigawa, Shigeru Shimamoto, Yuji Hidaka, 61st Annual Meeting of Biophysical Scoiety,   2017 02 12
  • Regulation of folding of de novo designed peptides by alpha-helix formation, Saya Nishihara, Kosuke Toyama, Shigeru Shimamoto, Yuji Hidaka, 61st Annual Meeting of Biophysical Scoiety,   2017 02 12
  • Preparation of a orexin precursor protein by chemical digestion, Natsumi Mitsuoka, Shigeru Shimamoto, Yuji Hidaka, 61st Annual Meeting of Biophysical Society,   2017 02 12
  • DISULFIDE-COUPLED FOLDING OF PRO-UROGUANYLIN ON MOLECULAR EVOLUTION, Kenta Mori, Kosuke Toyama, Shigeru Shimamoto, Yuji Hidaka, 10th International Peptide Symposium,   2016 10 26
  • ACTIVATION MECHANISM OF COCOONASE, Nagisa Tajima, Shigeru Shimamoto, Mitsuhiro Miyazawa, Yuji Hidaka, 10th International Peptide Symposium,   2016 10 26
  • REGULATION OF DISULFIDE-COUPLED FOLDING OF DE NOVO DESIGNED PEPTIDES BY alpha-HELIX FORMATION, Saya Nishihara, Kosuke Toyama, Shigeru Shimamoto, Yuji Hidaka, 10th International Peptide Symposium,   2016 10 26
  • PREPARATION OF A OREXIN PRECORSOR PROTEIN USING E. COLI EXPRESSION SYSTEM BY ACID TREATMENT, Natsumi Mitsuoka, Shigeru Shimamoto, Yuji Hidaka, 10th International Peptide Symposium,   2016 10 26

Misc

  • Structure and activity of heat-stable enterotoxin, HIDAKA Yuji, 68, 8, 1448, 1452,   1996 08 25 , http://ci.nii.ac.jp/naid/10009409843