KINDAI UNIVERSITY


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YASUDA Tadashi

Profile

FacultySocial Relationship promotion Center
PositionProfessor
DegreePhD in Medicine, Master of Public Health
Commentator Guidehttps://www.kindai.ac.jp/meikan/1510-yasuda-tadashi.html
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Last Updated :2020/09/02

Education and Career

Education

  •   1978 04  - 1984 03 , Osaka University, School of medicine
  •   1999 07  - 2000 05 , The Johns Hopkins University, School of hygiene and Public Health

Academic & Professional Experience

  •   2016 07 ,  - 現在, Professor, Social relations liaison center, Kinki University
  •   2012 05 ,  - 2016 06 , Health Manager, Health and Nutrition Section, United Nations Children's Fund Tanzania
  •   2010 09 ,  - 2012 06 , HIV advisor, Children and AIDS, Unicef Viet Nam
  •   2005 05 ,  - 2010 09 , Chief HIV, Health, Nutrition, HIV, Unicef Myanmar
  •   2000 07 ,  - 2005 04 , Medical Officer, Bureau of International Cooperation, International Medical Center of Japan
  •   2001 05 ,  - 2003 01 , Chief advisor, HIV prevention and care project in Thailand
  •   1995 01 ,  - 1999 06 , Surgeon, Surgery, Yao Municipal Hospital
  •   1993 11 ,  - 1994 11 , Traumatologist, Emergency medical system project, Sarawak Malaysia, Japan International Cooperation Agency
  •   1992 07 ,  - 1993 10 , Surgeon, Surgery, Uchinomi hospital
  •   1988 07 ,  - 1992 06 , Center for Molecular and Cellular Biology, Osaka University
  •   1986 06 ,  - 1988 06 , Resident, Surgery, Center for adult diseases
  •   1985 07 ,  - 1986 05 , Resident, Senri Critical Care Medical Center
  •   1984 08 ,  - 1985 06 , Trainee doctor, Surgery 2, Osaka University Hospital

Research Activities

Research Areas

  • Life sciences, Hygiene and public health (non-laboratory)
  • Life sciences, Hygiene and public health (laboratory)
  • Life sciences, Hygiene and public health (non-laboratory)
  • Life sciences, Hygiene and public health (laboratory)

Research Interests

  • Health system, Immunization, HIV prevention and contrrol, Maternal and Child Health, International Health

Published Papers

  • HIV/AIDS制圧を目指す多角的予防・ケアサポート政策, 70(12), 991 - 994, 2006 , Refereed
  • HIV/AIDS Epidemic in East Asia and Its Challenges, 安田直史, 樽井正義, 木原正博, 日本エイズ学会誌, 日本エイズ学会誌, 7(2), 77 - 82, May 20 2005
  • 東南アジアにおけるHIV/AIDS流行の現状と課題, 有吉紅也, 安田直史, 日本医事新報, 日本医事新報, 4218, 110 - 111, 2005
  • エイズ対策は成功したか 成功したタイのエイズ予防対策, 安田直史, 宮本英樹, 公衆衛生, 公衆衛生, 67(12), 914 - 919, Dec. 15 2003
  • A Case of Alpha-Fetoprotein Producing Gastric Cancer Suggestive of Multiple Differentiation., 江口英利, 矢野外喜治, 安田直史, 田中利一, 野村孝, 奥田博, 日本臨床外科医学会雑誌, 日本臨床外科医学会雑誌, 58(6), 1245 - 1249, Jun. 1997
  • A case of IGF-II producing rectal cancer with recurrent hypoglycemia., 安田直史, 岡見次郎, 武元浩新, 江口英利, 藤田彰一, 田中利一, 矢野外喜治, 野村孝, 奥田博, 日本消化器病学会雑誌, 日本消化器病学会雑誌, 94(3), 210 - 214, Mar. 1997
  • Behavior and role of resident medical staff members and neighboring hospitals in the Great Hanshin Earthquake., 中川英刀, 安田直史, 鵜飼卓, 日本救急医学会雑誌, 日本救急医学会雑誌, 7(12), 749 - 754, Dec. 1996
  • Specific expression of the pancreatic-secretory-trypsin- inhibitor (PSTI) gene in hepatocellular carcinoma., Ohmachi Y, Murata A, Matsuura N, Yasuda T, Yasuda T, Monden M, Mori T, Ogawa M, Matsubara K, Int J Cancer., Int J Cancer., 55(5), 65 - 73, 1994 , Refereed
  • Enhanced attachment and elastase-releasing capacity of neutrophils after surgery., Oka Y, Murata A, Nishijima J, Yasuda T, Hiraoka N, Ohmachi Y, Yasuda T, Kitagawa K, Toda H, Tanaka N, Am J Surg., Am J Surg., 167(4), 405 - 411, 1994 , Refereed
  • Establishment of EGF, EGF-R and FN-R positive human adenocarcinoma cell line (GAC-1)., 大間知祥孝, 村田厚夫, 松浦成昭, 安田直史, 安田卓司, 高田直樹, 岡義雄, 平岡伸章, 森武貞, Hum Cell, Hum Cell, 5(3), 267 - 272, Sep. 1992
  • Mechanism of Desmoplastic Reaction of Pancreatic Cancer. Effect of pancreatic secretory trypsin inhibitor(PSTI) on growth of cultured fibroblasts and cultured pancreatic cancer cells., 大間知祥孝, 村田厚夫, 安田直史, 松浦成昭, 西部俊三, 新居延高宏, 西島準一, 小川道雄, 森武貞, すい臓, すい臓, 6(5), 533 - 541, Oct. 1991
  • Inhibitory effect of pentoxifylline and prostaglandin E1 on the release of neutrophil elastase from FMLP-stimulated neutrophils., Oka Y, Murata A, Nishijima J, Hiraoka N, Yasuda T, Kitagawa K, Ogawa M, Mori T, J. Med, J. Med, 22(6), 371 - 382, 1991 , Refereed
  • Pathosis and treatment of severe acute pancreatitis. The pathophysiology and treatment of the multiple organ failure in severe acute pancreatitis., 岡義雄, 小川道雄, 村田厚夫, 西じま準一, 宮内啓輔, 宇田憲市, 新居延高宏, 安田直史, 森武貞, 月刊消化器科, 月刊消化器科, 13(3), 330 - 333, Sep. 1990
  • Changes in serum cytokine levels after surgical intervention and the mechanism of the induction of acute phase reactants., 村田厚夫, 小川道雄, 安田直史, 岡義雄, 大間知祥孝, 平岡伸章, 森武貞, 日本外科学会雑誌, 日本外科学会雑誌, 91(9), 1162 - 1165, Sep. 1990
  • Comparative Study of Portal Hemodynamics and Regional Hepatic Blood Flow before and after Hepatic Resection by 133Xe-Scintiphotosplenoportography, Tadashi Yasuda, Yo Sasaki, Shingi Imaoka, Takashi Shibata, Hisashi Wada, Hiroaki Nagano, Takeshi Iwanaga, Shunichi Nakano, Yoshihisa Hasegawa, Japanese Journal of Gastroenterological Surgery, Japanese Journal of Gastroenterological Surgery, 23(7), 1838 - 1841, Feb. 01 1990
    Summary:Changes in the portal circulatory pattern and regional hepatic blood flow (rHBF) after surgical liver resection were studied by 133Xe-scintiphotosplenoportography (SSP). The visual patterns of pre-and postoperative portal circulation were compared. Different patterns were observed after the operation in five of 27 patients (porto systemic shunt formation 3, progression 1, regression 1). The patients with portosystemic shunt showed postopertive complications (massive ascites, jaundice, cardiopulmonary failure) more frequently than those without it. The ratio of rHBF increase (post-/pre-operative rHBF) was 1.36 ± 0.63 on average. The ratio was higher in patients with good liver function or without liver cirrhosis. The ratio also correlated with the weight of the liver resected. But operation time, blood loss or whether hepatic bloodsupply was clamped off during the operation did not affect the ratio. Resection in the right lobe, however, caused a greater rHBF increase in the residual liver than the same degree of resection in the left lobe. SSP could be a useful method for investigating the effect of hepatic resection on portal hemodynamics and it is suggested that existence of portosystemic shunt influences the postoperative course. © 1990, The Japanese Society of Gastroenterological Surgery. All rights reserved.
  • Hypoglycemia induced by insulin antibody during postoperative management with intravenous hyperalimentation - A case report and qualitative analysis of insulin antibody., 安田直史, 石川治, 大東弘明, 古河洋, 今岡真義, 岩永剛, 笹隅富治子, 日本外科学会雑誌, 日本外科学会雑誌, 90(6), 949 - 952, Jun. 1989
  • Pancreatic diseases and pancreatic enzymes. With special reference to pancreatic enzymes in blood as pancreatic cancer markers., 小川道雄, 村田厚夫, 宮内啓輔, 宇田憲市, 土居貞幸, 横内秀起, 岡義雄, 安田直史, 森武貞, 臨床科学, 臨床科学, 25(5), 606 - 615, May 1989
  • Trial of administration of urinastatin (Miracrid) the airway for ARDS (adult respiratory distress syndrome)., 柴田高, 佐々木洋, 今岡真義, 石川治, 大東弘明, 安田直史, 和田尚, 永野浩昭, 岩永剛, 新薬と臨床, 新薬と臨床, 38(3), 445 - 449, Mar. 1989
  • Analysis of action mechanisms of pancreatic secretory trypsin inhibitors as proliferating factors and its application to treatment of malignant tumors., 小川道雄, 安田直史, 新居延高宏, 村田厚夫, 森武貞, がん治療のあゆみ, がん治療のあゆみ, 9, 63 - 70, 1989
  • The Effect of Transcatheter Arterial Chemo-Embolization Combined Lipiodol, to Tumor Embolus in the Hepatic Vein of Hepatocellular Carcinoma, Yasuo Miyoshi, Yo Sasaki, Shingi Imaoka, Takashi Shibata, Tadashi Yasuda, Hisashi Wada, Hiroaki Nagano, Osamu Ishikawa, Hiroshi Furukawa, Takeshi Iwanaga, the japanese journal of gastroenterological surgery, the japanese journal of gastroenterological surgery, 23(5), 1168 - 1172, Feb. 01 1988
    Summary:To two cases of hepatocellular carcinoma with tumor emboli in the hepatic vein, we performed hepatectomy after Lipiodol transcatheter arterial chemo-embolization (LPD-TAE). We estimated the histological effect of LPDTAE on these tumor emboli in the hepatic vein. The conclusion was as follows: in case 1, the tumor embolus in the right hepatic vein was completely necrosed. Daughter nodules were diagnosed histologically as solid type Edmondson grade II hepatocellular carcinoma. The angiographic appearance showed no “thread and streaks” sign in this embolus. In case 2, the effect was only partial necrosis of the tumor embolus in the right hepatic vein. Histologically, sinusoidal type Edmondson grade III hepatocellular carcinoma was found in the tumor embolus and daughter nodules. Angiographically, the “thread and streaks” sign was clearly recognized in this embolus. Then, like these cases, the existence of the angiographic “thread and streaks” sign might lead to poor effect of LPD-TAE to tumor embolus in the hepatic vein of hepatocellular carcinoma. © 1990, The Japanese Society of Gastroenterological Surgery. All rights reserved.
  • Effectiveness of preoperative transcatheter arterial embolization for improved survival rates in patients with hepato-cellular carcinomas (sandwich therapy using ethiodized oil, cisplatin and gelatin sponge), T. Shibata, Y. Sasaki, S. Imaoka, T. Yasuda, H. Wada, O. Ishikawa, H. Ohigashi, I. Fukuda, T. Kabuto, M. Hiratsuka, M. Kameyama, H. Furukawa, H. Koyama, T. Iwanaga, M. Fujita, Japanese Journal of Cancer and Chemotherapy, Japanese Journal of Cancer and Chemotherapy, 15(8), 2514 - 2519, 1988
  • Administration of fat emulsion with nutritional mixture in one-pack total parenteral nutrition for patients of hypertriglyceridemia., 三好康雄, 安田直史, 小山博記, 今岡真義, 土井修, 岩永剛, JJPEN, JJPEN, 9(6), 855 - 858, Nov. 1987
  • DEMOGRAPHIC, SOCIO-ECONOMIC, BEHAVIORAL AND CLINICAL FACTORS PREDICTING VIROLOGIC FAILURE WITH GENERIC FIXED-DOSE COMBINATION ANTIRETROVIRAL THERAPY BEFORE UNIVERSAL HEALTH INSURANCE COVERAGE IN NORTHERN THAILAND, Naho Tsuchiya, Panita Pathipvanich, Tadashi Yasuda, Yumi Mukoyama, Archawin Rojanawiwat, Toru Matsubayashi, Siriphan Saeng-aroon, Wattana Auwanit, Akiko Matsuyama, Pathom Sawanpanyalert, Koya Ariyoshi, SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, 40(1), 71 - 82, Jan. 2009 , Refereed
    Summary:We conducted a 2-year prospective cohort study to investigate multiple aspects of factors predicting the outcome Of fixed-dose combination antiretroviral (ARV) therapy with lamivudine, stavudine, and nevirapine (GPOvir (R)) at a government referral hospital in northern Thailand. At 6 and 24 months after the initiation of GPOvir (R) viral load (VL) was measured to determine virologic failure (>400 RNA copies/ml) and demographic, socio-economic, behavioral and clinical data were collected. From 10 April 2002 to 31. January 2004, 409 patients participated in this Study: 64/364 (17.0%) at 6 months and 55/345 (15%,) at 24 months virologically failed treatment. On univariate analysis, besides ARV experience [odds ratio (OR), 3.08, 95% confidence interval (0), 1.71-5.57] and the frequency of delayed doses (OR, 2.97; 95%, Cl, 1.47-6.00), we identified one socioeconomic factor significantly associated with virologic failure: "not having child" (OR, 1.85; 95%, CI, 1.03 - 3.34). Although the association with "not having child" became marginal oil multivariate analysis, results of in-depth interviews and group discussions indicated that having a child was a strong motivating factor for good treatment compliance. We suggest that patients Without children may need more attention. Further investigation of socio-economic factors is warranted.
  • Post-flood-Infectious diseases in Mozambique, Hisayoshi Kondo, Norimasa Seo, Tadashi Yasuda, Masahiro Hasizume, Yuichi Koido, Norifumi Ninomiya, Yasuhiro Yamamoto, Prehospital and Disaster Medicine, Prehospital and Disaster Medicine, 17(3), 126 - 133, 2002 , Refereed
    Summary:Introduction: The types of medical care required during a disaster are determined by variables such as the cycle and nature of the disaster. Following a flood, there exists the potential for transmission of water-borne diseases and for increased levels of endemic illnesses such as vector-borne diseases. Therefore, consideration of the situation of infectious diseases must be addressed when providing relief. The Japan Disaster Relief ( JDR) Medical Team was sent to Mozambique where a flood disaster occurred during January to March 2000. The team operated in the Hokwe area of the State of Gaza, in the mid-south of Mozambique where damage was the greatest.Methods: An epidemiological study was conducted. Information was collected from medical records by abstracting data at local medical facilities, interviewing in habitants and evacuees, and conducting analyses of water.Results: A total of 2,611 patients received medical care during the nine days. Infectious diseases were detected in 85% of all of patients, predominantly malaria, respiratory infectious diseases, and diarrhea. There was no outbreak of cholera or dysentery. Self-reports of the level of health decreased among the flood victims after the event. The incidence of malaria increased by four to five times over non-disaster periods, and the quality of drinking water deteriorated after the event.Conclusions: Both the number of patients and the incidence of endemic infectious diseases, such as malaria and diarrhea, increased following the flood. Also, there was a heightening of risk factors for infectious diseases such as an increase in population, deterioration of physical strength due to the shortage of food and the temporary living conditions for safety purposes, and turbid degeneration of drinking water. These findings support the hypotheses that there exists the potential for the increased transmission of water borne diseases and that there occurs increased levels of endemic illnesses during the post-flood period. © 2002 World Association for Disaster and Emergency Medicine.
  • Identification of novel pancreas-specific regulatory sequences in the promoter region of human pancreatic secretory trypsin inhibitor gene, T Yasuda, T Yasuda, Y Ohmachi, M Katsuki, M Yokoyama, A Murata, M Monden, K Matsubara, JOURNAL OF BIOLOGICAL CHEMISTRY, JOURNAL OF BIOLOGICAL CHEMISTRY, 273(51), 34413 - 34421, Dec. 1998 , Refereed
    Summary:The human pancreatic secretory trypsin inhibitor (PSTI) genes introduced into mice are specifically expressed in pancreas. The 1.0 kilobase pairs of PSTI 5'-flanking sequence directed preferential expression of a linked reporter chloramphenicol acetyltransferase, which was active in a PSTI-expressing pancreatic cell line (AR42j) but not in a PSTI-nonexpressing fibroblast cell line (XC). Two positively acting elements were found, Region I (-161/-116) and Region PI (-103/-74), as defined by transfection and binding assays with ARA2j cells. Region II is sufficient for the pancreas-specific expression, but the presence of both Regions I and II is needed for the maximum activity. Sequence studies also revealed that these two elements differ from the previously identified recognition sequence for pancreas transcription factor 1 (PTF1), When the same set of experiments was done with XC cells, one negatively acting element was identified, Region IV(-154/-137), Interestingly, Regions I and IV share a core sequence (-149/ -139), CAATCAATAAC. These results suggest that this novel element regulates the human PSTI gene expression positively in pancreatic cells but negatively in nonpancreatic cells.
  • PyNPase activity in primary and metastatic colorectal cancer, M. Kameyama, S. Nakamori, S. Imaoka, T. Yasuda, H. Ohigashi, M. Hiratsuka, Y. Sasaki, T. Kabuto, O. Ishikawa, H. Furukawa, T. Iwanaga, H. Yokouchi, O. Doi, Japanese Journal of Cancer and Chemotherapy, Japanese Journal of Cancer and Chemotherapy, 24(5), 563 - 567, 1997 , Refereed
    Summary:5'-Deoxy-5-fluorouridine (5'-DFUR) is converted to 5-FU by the enzyme of pyrimidine nucleoside phosphorylase (PyNPase). Its efficacy for lung metastases from colorectal cancer is known. So we investigated PyNPase activity in primary and metastatic lesions of colorectal cancer patients. The results revealed that PyNPase activity (μ g 5-FU/mg protein/hour) mean±SD) was 122.1±61.1 (n=48) in primary lesions. 91.6±48.3 (n=4) in lymphnode metastases. 135.2±56.4 (n=10) in liver matastases and 168.2±79.8 (n=11) in lung metastases. In non-cancerous tissues adjacent to the cancer lesions. PyNPase activity was 51.5 ± 18.8 in normal colorectal mucosa, 61.8±24.7 in normal liver and 43.0±21.2 in normal lung. These results demonstrated that PyNPase activity in the cancer lesions reached significantly higher levels than in the non-cancerous tissues (p< 0.01) and the T/N ratio of PyNPase activity in lung was also significantly higher than in primary or other metastatic lesions (p < 0.05). It was surmised that the clinical response of colorectal cancer to 5'-DFUR had been influenced by PyNPase activity.
  • EXPRESSION OF THE PANCREATIC SECRETORY TRYPSIN-INHIBITOR GENE IN THE LIVER INFECTED WITH HEPATITIS-B VIRUS, Y OHMACHI, A MURATA, T YASUDA, K KITAGAWA, S YAMAMOTO, M MONDEN, T MORI, N MATSUURA, K MATSUBARA, JOURNAL OF HEPATOLOGY, JOURNAL OF HEPATOLOGY, 21(6), 1012 - 1016, Dec. 1994 , Refereed
    Summary:Pancreatic secretory trypsin inhibitor, an acute phase reactant protein, is expressed in the liver in response to inflammatory cytokines, especially in hepatocellular carcinoma. Northern blots of 25 dissected liver tissues from non-hepatitis, chronic hepatitis and cirrhosis patients revealed that 10 (40%) expressed pancreatic secretory trypsin inhibitor. The expression seemed to be closely associated with hepatitis B viral infection, since among the 11 hepatitis B virus-infected samples, nine (81%) were pancreatic secretory trypsin inhibitor-positive. In contrast, this augmented expression was absent in noninfected livers (0/5; 0%), and rare in those infected with hepatitis C virus (1/9; 11%). There was no significant correlation between the pancreatic secretory trypsin inhibitor expression in the liver and the serum level of glutamic pyruvic transaminase, the hepaplastin test, the 15-min retention rate of indocyanine green, or the histological findings of the liver tissues such as lymphocyte infiltration and pseudolobular formation. Furthermore, we identified an almost three-fold increase in the transactivation of pancreatic secretory trypsin inhibitor gene expression in HepG2 cells after transient transfection with HBV-DNA or the X gene in an expression vector. These results suggest that the induction of pancreatic secretory trypsin inhibitor gene expression in livers with chronic hepatitis and cirrhosis is directly affected by hepatitis B virus. (C) Journal of Hepatology.
  • OVEREXPRESSION OF PANCREATIC SECRETORY TRYPSIN-INHIBITOR IN PANCREATIC-CANCER - EVALUATION OF ITS BIOLOGICAL FUNCTION AS A GROWTH-FACTOR, Y OHMACHI, A MURATA, N MATSUURA, T YASUDA, K UDA, T MORI, INTERNATIONAL JOURNAL OF PANCREATOLOGY, INTERNATIONAL JOURNAL OF PANCREATOLOGY, 15(1), 65 - 73, Feb. 1994 , Refereed
    Summary:Four clones of pancreatic secretory trypsin inhibitor (PSTI)-overexpressing cells (TF-PANC clones 1, 6, 8, and 36) were established to evaluate the physiological function of PSTI secreted by cancer cells, by means of introducing a PSTI-expression vector (pRSV-PSTI) into the human pancreatic adenocarcinoma cell line (PANC-1). No obvious changes were observed in the histological features of these transplanted tumors in nude mice, in the growth of TF-PANC and PANC-1, or that of 3T3 fibroblasts when cocultured with them. Addition of recombinant human PSTI to the cultured media resulted in no increase in proliferation of fibroblasts (3T3 and WI-38) or of four pancreatic cancer cell lines (PANC-1, CAPAN-I, MIAPaCa-2, and Hs766T). These results suggest that the estimation of tumor-bearing PSTI as a paracrine or autocrine growth factor in recent studies should be given careful consideration.
  • IDENTIFICATION OF THE IL-6-RESPONSIVE ELEMENT IN AN ACUTE-PHASE-RESPONSIVE HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR-ENCODING GENE, T YASUDA, M OGAWA, A MURATA, Y OHMACHI, T YASUDA, T MORI, K MATSUBARA, GENE, GENE, 131(2), 275 - 280, Sep. 1993 , Refereed
    Summary:Pancreatic secretory trypsin inhibitor (PSTI) has been suggested to be an acute-phase reactant in humans and to be induced by inflammatory cytokines such as the interleukins IL-1 and IL-6. We report that PSTI is synthesized in hepatoma cells and that the gene expression is augmented by IL-6. The start points (tsp) for basal and augmented transcription are exactly the same as the tsp in normal pancreas. Analysis of the PSTI gene revealed that a 40-bp DNA fragment located between kb - 3.84 and - 3.80 carries the element responsible for both basal transcriptional activity and IL-6-induced gene expression. This 40-bp fragment contains T(G)T(NNGNAA)G(T), the consensus sequence for the NF-IL6-binding site, which is also known as the IL-6-responsive element that is conserved among various acute-phase genes. The basal activity was augmented by another sequence that lies between kb - 4.0 and - 3.9.
  • CIRCULATING INTERLEUKIN-6 AS A USEFUL MARKER FOR PREDICTING POSTOPERATIVE COMPLICATIONS, Y OKA, A MURATA, J NISHIJIMA, T YASUDA, N HIRAOKA, Y OHMACHI, K KITAGAWA, T YASUDA, H TODA, N TANAKA, T MORI, CYTOKINE, CYTOKINE, 4(4), 298 - 304, Jul. 1992 , Refereed
  • RADIOISOTOPIC DETECTION OF PORTAL HEMODYNAMIC-CHANGES AFTER LIVER SURGERY, T YASUDA, Y SASAKI, S IMAOKA, T SHIBARTA, H WADA, T IWANAGA, Y HASEGAWA, EUROPEAN JOURNAL OF RADIOLOGY, EUROPEAN JOURNAL OF RADIOLOGY, 13(2), 118 - 121, Sep. 1991 , Refereed
  • EXPRESSION OF ALPHA-AMYLASE ISOZYMES IN HUMAN THYROID TISSUES, S DOI, N TOMITA, M HIGASIYAMA, H YOKOUCHI, A HORII, T YASUDA, T KOBAYASHI, S TAKAI, M OGAWA, T MORI, K MATSUBARA, CANCER RESEARCH, CANCER RESEARCH, 51(13), 3544 - 3549, Jul. 1991 , Refereed
    Summary:Expression of alpha-amylase genes in thyroid tissues was studied by assaying the total amylase activity as well as by using immunohistochemical and Northern blot analysis. The amylase genes expressed were determined by a combination of the polymerase chain reaction (PCR) and blot analysis using synthetic probes specific for the three known amylase isozyme complementary DNAs. The samples consisted of tissues from 18 human thyroid carcinomas (11 well-differentiated carcinomas, 2 poorly differentiated carcinomas, 1 anaplastic carcinoma, and 4 medullary carcinomas) and 9 specimens of nonmalignant thyroid tissue (2 were from nontumorous regions of resected glands and 7 were thyroid tissue from a patient with Graves' disease). Salivary-type amylase was expressed at a relatively high level in nonmalignant thyroid tissue and well-differentiated carcinoma and could be detected by Northern blot analysis. In poorly differentiated carcinoma, it was detected only by the PCR, while in anaplastic or medullary carcinoma, it was not detected even by the PCR. Thus, the expression of salivary-type amylase was characteristic of well-differentiated follicular cells. These observations suggest that salivary-type amylase expression may be a marker for identifying the histogenesis and stage of differentiation of thyroid cancer. In addition, the AMY2B gene product was detected in all different types of cells examined, although its expression was only detectable by the PCR. Pancreatic type amylase was not detected in any of the samples.
  • RESPONSE TO IL-6 STIMULATION OF HUMAN HEPATOBLASTOMA CELLS - PRODUCTION OF PANCREATIC SECRETORY TRYPSIN-INHIBITOR, T YASUDA, M OGAWA, A MURATA, Y OKA, K UDA, T MORI, BIOLOGICAL CHEMISTRY HOPPE-SEYLER, BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 371(s), 95 - 100, May 1990 , Refereed
  • SERUM IMMUNOREACTIVE PANCREATIC PHOSPHOLIPASE-A2 IN PATIENTS WITH VARIOUS MALIGNANT-TUMORS, Y OKA, M OGAWA, Y MATSUDA, A MURATA, J NISHIJIMA, K MIYAUCHI, K UDA, T YASUDA, T MORI, ENZYME, ENZYME, 43(2), 80 - 88, 1990 , Refereed
  • SERUM INTERLEUKIN-6, C-REACTIVE PROTEIN AND PANCREATIC SECRETORY TRYPSIN-INHIBITOR (PSTI) AS ACUTE PHASE REACTANTS AFTER MAJOR THORACOABDOMINAL SURGERY, A MURATA, M OGAWA, T YASUDA, J NISHIJIMA, Y OKA, Y OHMACHI, N HIRAOKA, T NIINOBU, K UDA, T MORI, IMMUNOLOGICAL INVESTIGATIONS, IMMUNOLOGICAL INVESTIGATIONS, 19(3), 271 - 278, 1990 , Refereed

Conference Activities & Talks

  • Analysis of characteristics of health personnel working for Global Health and Domestic Rural Health, Yasuda Tadashi, The 33rd Congress of Japan Association for International Health,   2018 12 01
  • Child Survival --- Already a done deal?, Yasuda Tadashi,   2017 11 26
  • 2011 Tsunami Disaster and UNICEF's Emergency Response., Tadashi Yasuda, Osaka University Forum on “Disaster Prevention, Post-Disaster Reconstruction and International Cooperation”,   2011 , 招待有り
  • Study on Access to Care, Treatment, and Support for Children and Women with HIV and AIDS among Communities of Ethnic Minority People in Vietnam, Chu Quoc An, Do Huu Thuy, Luu Thi Hong, Duong Hai Ngoc, Nguyen Ngoc Trieu, Tadashi Yasuda, Trinh Huu Vach, International Congress on AIDS in Asia and the Pacific,   2011
  • PMTCT data for prevalence mapping and monitoring the response- - - Usefulness of PMTCT data in place of surveillance data - - -, Yasuda Tadashi, Ohnmar Aung, Tin Htut, Thaingi Aung, Khin Ohnmar San, International AIDS conference,   2010
  • 「世界のいのち」と「日本のいのち」<特別講演>, Yasuda Tadashi, 緒方洪庵生誕200周年記念公開講座,   2010 , 招待有り
  • 医師として国際保健医療協力に携わるということ <特別講演>, Yasuda Tadashi,   2010 , 招待有り
  • タイ国ランパーン県におけるジェネリック抗HIV薬治療失敗に影響する人類学的,社会的,行動学的,臨床的因子の研究, 土屋菜歩, PATHIVANICH Panita, 安田直史, SANWAYANWALERT Pathom, 有吉紅也, 日本エイズ学会誌,   2007 11 20
  • タイ国ランパーン県におけるHAART療法治療失敗の関連因子とアドヘレンスモニタリング・評価方法に関する研究, 土屋菜歩, PATHIVANICH Panita, 安田直史, 向山由美, SAWANPANYALERT Pathom, 有吉紅也, Trop Med Health,   2006 10
  • HIV Testing Behavior and HIV Voluntary Testing and Counseling Experiences among Dense Populations in Bangkok, Thailand, Yasuda Tadashi, Orratai Rhucharoenpornpanich, Chawin Sirinak, Ubonrat Thanarujiwong, International Congress on AIDS in Asia and the Pacific,   2005
  • バンコクの密集居住地におけるHIVテスト受検行動に関する研究, 安田直史, RHUCHAROENPORNPANICH Orratai, 国際保健医療,   2004 10
  • HIV感染者のケア・ARV治療に関するアジア・アフリカ諸国の現状分析, 若杉なおみ, 西山綾子, 岩永典子, 安田直史, 岡慎一, 国際保健医療,   2004 10
  • 北タイの病院における抗レトロウィルス薬治療結果に影響を与える要因の分析, Yasuda Tadashi,   2004
  • Study of risk factors influencing antiretroviral drug treatment failure among HIV/AIDS patients attending a government hospital in northern Thailand., Panita Pathipvanich, Archawin Rojanawiwat, Siriphan Seangaroon, Jirawan Srisawat, Yumi Mukoyama, Hideki Miyamoto, Tadashi Yasuda, Wattana Auwanit, Koya Ariyoshi, Pathom Sawanpanyalert, International AIDS conference, Bangkok, Thailand,   2004
  • Extramarital sex among people living in crowded communities in Bangkok., Orratai Rhucaroenpornpanich, Yasuda Tadashi, Chawin Sirinak, Ubonrat Thanarujiwong, International AIDS conference, Bangkok, Thailand,   2004
  • HIV/AIDS care services for asymptomatic HIV-infected persons in Northern Thailand., Tasana Leusaree, Sakchai Dettrairat, Unchalee Pultajuk, Ratana Chaifongsri, Darawadee Nunthakwang, Pimjai Satasit, Chiyoko Mori, Tadashi Yasuda, Ying Ru Lo, International AIDS conference, Bangkok, Thailand,   2004
  • PLHA involvement in healthcare system for provision of antiretroviral therapy in northern Thailand., Panpanich R, Sornchai P, Tadashi Y, Leuseree T, Khemngern P, Vitsupakorn K, International AIDS conference, Bangkok, Thailand,   2004
  • HIV/TB perception among dense population in Bangkok, Thailand., O Rhucaroenpornpanich, Y. Tadashi, C Sirinak, W. Lewluck, U Thanarujiwong, International AIDS conference, Bangkok, Thailand,   2004
  • わが国の感染症対策における国際貢献―エイズ対策。ODA 評価セミナー 世界の感染症流行に対する日本の貢献 <基調講演>, Yasuda Tadashi,   2004 , 招待有り
  • タイにおけるHIV・AIDSケアの状況の変化, 安田直史, 宮本英樹, 森千代子, 日本熱帯医学会雑誌,   2003 10 10
  • The progress of HIV/AIDS care system in northern Thailand,, Tadashi, Miyamoto Hideki, Mori Chiyoko, 日本国際保健医療学会,   2003
  • Development of guiding tool for assessing and monitoring TB program in HIV prevalent area: Facilitating District’s Responses to the Dual Epidemic in Northern Thailand., Suthat Mahawanasri, Petchsri Sirinirund, Chalong Arkarachinores, Masami Fujita, Yutaka Ishida, Chiyoko Mori, Tadashi Yasuda, International Congress on AIDS in Asia and the Pacific, Melbourne, Australia,   2001
  • Network development for HIV/AIDS care - Where community care meets the health system -, Yasuda Tadashi, Miyamoto Hideki, Mori Chiyoko, International Conference on Home and Community based Care for People Living with HIV/AIDS, Chiang Mai, Thailand,   2001
  • Reducing the burden of motorcycle injury in a rural state of Malaysia., Yasuda Tadashi, Johns Hopkins symposium, Baltimore, USA,   2000
  • Pancreatic Secretory Trypsin Inhibitor as a fibroblast growth factor., Yasuda Tadashi, Michio Ogawa, International conference on proteinase and proteinase inhibitor, Ljubljana, Yugoslavia,,   1998 , 招待有り
  • 中心国における保健医療ニーズ,   1994
  • 非膵疾患における血中膵phospholipase A-2(PLA-2)測定の意義,   1990
  • 重症膵炎に合併する多臓器不全の発生防止に関する実験的検討,   1990
  • Secretion of pancreas secreting trypsin inhibitor (PSTI) from cultured human hepatoma cells by IL-6., 安田直史, 小川道雄, 村田厚夫, 岡義雄, 大間知祥孝, 平岡伸章, 宇田憲市, 日本臨床代謝学会記録,   1989
  • Blood PSTI levels as a new marker for determination of inversion and biological reactions., 宇田憲市, 小川道雄, 岡義雄, 安田直史, 西じま準一, 宮内啓輔, 村田厚夫, 森武貞, 日本臨床代謝学会記録,   1989
  • Physiological function of pancreatic secretory trypsin inhibitor (PSTI) produced by malignant tumors., 村田厚夫, 小川道雄, 安田直史, 岡義雄, 奥邦彦, 東山聖彦, 宇田憲市, 森武貞, 日本臨床代謝学会記録,   1989
  • Involvement of activated neutrophils in manifestation of multiple organ failure in severe pancreatitis., 岡義雄, 小川道雄, 村田厚夫, 宇田憲市, 安田直史, 奥邦彦, 森武貞, 日本臨床代謝学会記録,   1989
  • 肝切除前後における肝組織血流量の測定とその意義 : 経脾門脈シンチグラフィーによる検討,   1988
  • 肝細胞癌に対するリピオドール併用TAEの検討:軟線写真像と病理所見との比較,   1988
  • 胃全摘出術後のインスリン併用高カロリー輸液中に, 抗インスリンの発生と低血糖症状を示した1例,   1987