KINDAI UNIVERSITY


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NAGAOKA Takashi

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FacultyDepartment of Computational Systems Biology / Graduate School of Biology-Oriented Science and Technology
PositionLecturer
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/1345-nagaoka-takashi.html
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Last Updated :2020/06/01

Education and Career

Education

  •   1996 04  - 2000 03 , Waseda University, School of Science and Engineering
  •   2000 04  - 2002 03 , Waseda University, Graduate School of Science and Engineering
  •   2002 04  - 2005 03 , Waseda University, Graduate School of Science and Engineering

Academic & Professional Experience

  •   2015 04 ,  - 現在, Faculty of Biology-Oriented Science and Technology, Department of Computational Systems Biology, Kindai University
  •   2009 04 ,  - 2015 03 , Faculty of Science and Engineering, Waseda University
  •   2003 04 ,  - 2006 03 , School of Science and Engineering, Waseda University

Research Activities

Research Areas

  • Life sciences, Dermatology
  • Life sciences, Medical systems
  • Life sciences, Digestive surgery
  • Life sciences, Biomaterials
  • Life sciences, Biomedical engineering

Published Papers

  • Performance Improvement of Automated Melanoma Diagnosis System by Data Augumentation, Advanced Biomedical Engineering, Advanced Biomedical Engineering, 9, 62 - 70, Mar. 19 2020 , Refereed
  • Quantitative cosmetic evaluation of long-lasting foundation using multispectral imaging., Nagaoka T, Kimura Y, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 25(3), 318 - 324, Jan. 2019 , Refereed
  • Recent Advances in Diagnostic Technologies for Melanoma, NAGAOKA Takashi, Advanced Biomedical Engineering, Advanced Biomedical Engineering, 5, 111 - 117, Jul. 2016 , Refereed
  • Portable hyperspectral imager with continuous wave green laser for identification and detection of untreated latent fingerprints on walls., Nakamura A, Okuda H, Nagaoka T, Akiba N, Kurosawa K, Kuroki K, Ichikawa F, Torao A, Sota T, Forensic science international, Forensic science international, 254, 100 - 105, Sep. 2015 , Refereed
  • Modification of a melanoma discrimination index derived from hyperspectral data: A clinical trial conducted in 2 centers between March 2011 and December 2013, T. Nagaoka, Y. Kiyohara, H. Koga, A. Nakamura, T. Saida, T. Sota, T. Sota, Skin Research and Technology, Skin Research and Technology, 21(3), 278 - 283, Aug. 2015 , Refereed
    Summary:Background: The morphology of pigmented skin lesions (PSLs) is predominantly a result of varying concentrations and distributions of pigmented molecules such as melanin and hemoglobin. Based on these differences and the fact that their information is contained in cutaneous spectra, a hyperspectral imager (HSI) for pigmented melanoma and a single discrimination index derived from the resultant hyperspectral data are proposed. Objective: To develop and evaluate a new discrimination index for melanomas, compared to the previous index. Methods: A HSI, which is convenient for both patients and clinicians, was newly developed and used in a clinical trial conducted in 2 centers with 80 patients with primary lesions and 17 volunteers between March 2011 and December 2013. There were 24 melanomas and 110 other PSLs. A previously proposed discrimination index was used without modifications. A new index, which emphasized the essential features of melanoma, was proposed, and its performance was examined. For each index, a threshold value was set to minimize the average value of the false positive and false negative fractions. The performances of both indices were compared. Results: The sensitivity and specificity of the old index were 75% and 97%, respectively, while those of the new index were 96% and 87%. Conclusion: The new index had a higher sensitivity and adequate specificity, indicating that it is more useful than the old index. © 2014 John Wiley & Sons A/S.
  • Development of a new measurement system to detect selectively volatile organic compounds derived from the human body, S. Kanou, T. Nagaoka, N. Kobayashi, M. Kurahashi, S. Takeda, T. Aoki, T. Tsuji, T. Urano, T. Abe, K. Magatani, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 3837 - 3840, Oct. 2013 , Refereed
    Summary:A new concept expired gas measurement system used double cold-trap method was developed. The system could detect selectively volatile organic compound (VOC) derived from the human body. The gas chromatography (GC) profiles of healthy volunteer's expired gas collected by our system were analyzed. As a result, 60 VOCs were detected from the healthy volunteer's expired gas. We examined 14 VOCs among them further, which could be converted to the concentration from the GC profiles. The concentration of almost VOCs decreased when the subjects inspired purified air compared with the atmosphere. On the other hand, isoprene was almost the same. It was strongly suggested that these VOCs were derived from the human body because the concentration of these VOCs in the atmosphere were nearly zero. Expired gas of two sleep apnea syndrome (SAS) patients were analyzed as preliminary study. As a result of the study, the concentration of some VOCs contained in the expired gas of the SAS patients showed higher value than a healthy controls. © 2013 IEEE.
  • Novel automated screening of age-related macular degeneration, Yasuyuki Yamauchi, Hiroyuki Kemma, Hiroshi Goto, Atsushi Nakamura, Takashi Nagaoka, Takayuki Sota, JAPANESE JOURNAL OF OPHTHALMOLOGY, JAPANESE JOURNAL OF OPHTHALMOLOGY, 56(6), 577 - 583, Nov. 2012
    Summary:To determine the objective and quantitative hyperspectral parameters for distinguishing between age-related macular degeneration (AMD) and a normal macula. Near-infrared hyperspectral images were taken of 71 eyes of 62 AMD patients with exudative AMD and 21 eyes of 12 control subjects without AMD. The spatial information included a 480 x 321-pixel image in a 50A degrees field located at the ocular fundus and a 720-950-nm-per-pixel reflectance spectrum. Macular vectors were determined as the average spectrum for each macula, and reference vectors were used as average macular vectors for healthy volunteers. Variations in vector length and angle were calculated based on comparison with the reference vector. The AMD differentiation index was a parameter that minimized the plot overlap between AMD patients and controls. Statistically significant differences between the AMD patients and controls were noted. Receiver-operating characteristic curve analysis revealed an area under the curve of 0.888. The appropriate threshold values were attained for the proposed discrimination index, including 68 % sensitivity, 95 % specificity and 74 % accuracy. This study presents a simplified diagnostic index for the determination of age-related macular degeneration based on near-infrared spectra.
  • Novel melanoma discrimination index from optical spectra, OKUTANI Haruka, NAKAMURA Atsushi, NAGAOKA Takashi, KIYOHARA Yoshio, SOTA Takayuki, Skin Cancer, Skin Cancer, 26(1), 94 - 97, May 2011 , Refereed
    Summary:The ABCD-rule of dermoscopy has increased diagnostic accuracy ; however, some training is required in using it efficiently, and the diagnosis based on morphology is to a large extent subjective as with any clinical diagnosis. Morphology mainly comes from spatial variegation in skin pigmentation, i.e. spatial change in pigment molecular species and their concentration. Optical spectra reflected from the skin carry information about it. An essential feature of melanoma is the variety in morphology of the lesion, which is equivalent to change in spectrum from portion to portion within the lesion. The hyperspectral imaging technique enables one to measure hyperspectral data (HSD) within a short period, which consist of both spatial and spectral information. In this paper, we propose a single melanoma discrimination index derived from HSD using the entropy concept, and demonstrate its usefulness.[Skin Cancer (Japan) 2011 ; 26 : 94-97]
  • A melanoma discrimination index based on optical spectra, NAGAOKA Takashi, NAKAMURA Atsushi, AIZAWA Katsuo, OHTSUBO Shinya, KIYOHARA Yoshio, SOTA Takayuki, Skin Cancer, Skin Cancer, 25(1), 81 - 84, May 2010 , Refereed
    Summary:The morphology of pigmented skin lesions (PSLs) comes from differences in distribution and in concentration of melanin and hemoglobin pigment molecules. Those differences may be analyzed qualitatively and quantitatively using diffuse reflectance spectra in the visible to near infrared wavelength region. We have expressed differences in concentration distribution of both pigment molecules numerically with the use of diffuse reflectance spectra varying from site to site. Performance of the parameter has been studied on fifteen cases of PSLs : six cases of melanoma, five cases of seborrheic keratosis, and four cases of nevus. It has been demonstrated that the parameter can discriminate melanoma from others with a sensitivity of 85% and a specificity of 91%. It has also been suggested that the parameter reflects both boundary irregularity and variation in colors of PSLs.[Skin Cancer (Japan) 2010 ; 25 : 81-84]
  • Development of blood vessel viewer using multi spectral imaging technology., Nagaoka T, Nakamura A, Aizawa K, Ohtsubo S, Mochizuki T, Kiyohara Y, Sota T, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2008, 1234 - 1237, 2008 , Refereed
  • Inspection of skin hemodynamics with hyperspectral camera., Nagaoka T, Eikje NS, Nakamura A, Aizawa K, Kiyohara Y, Ichikawa F, Yamazaki T, Doi M, Nakamura K, Otsubo S, Sota T, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2007, 3357 - 3361, 2007 , Refereed
  • Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system., Suzaki H, Kobayashi N, Nagaoka T, Iwasaki K, Umezu M, Takeda S, Togawa T, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 1, 799 - 802, 2006 , Refereed
  • Relation between hematocrit and optical density in pulse oximetry -In vitro study with Waseda mock circulatory system, H. Suzaki, H. Suzaki, N. Kobayashi, H. Kubota, T. Aomi, T. Nagaoka, K. Iwasaki, M. Umezu, S. Takeda, S. Takeda, A. Uchiyama, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 7 VOLS, 2626 - 2629, Dec. 2005 , Refereed
    Summary:Optical properties of living tissues have not been well established even today, and bioopticinstrumentations have to be based on empirical formulae. In order to examine optical properties of the tissue having pulsating blood perfusion, we investigated the relation between optical density (defined as O.D.) of whole blood and hematocrit by transmission spectrophotometry. We used Waseda mock circulatory system that simulates blood circulation in the tissue. It was found that with increasing light path length, O.D. per unit light path length due to scattering and absorption effect, tended to become constant in each hematocrit. For wavelengths of 660, 805 and 940 nm, the relations between O.D. of whole blood and hematocrit predicted by Twersky's equation, Loewinger's equation and photon diffusion equation fitted to the data obtained. Meanwhile, for 1300 nm, the relation predicted by Loewinger's equation gave the best fit to the data. © 2005 IEEE.
  • Development and Application of a Three-dimensional Position Sensor Using a Permanent Magnet, NAGAOKA Takashi, ICHIKAWA Daisuke, UCHIYAMA Akihiko, Transactions of the Japanese Society for Medical and Biological Engineering : BME, Transactions of the Japanese Society for Medical and Biological Engineering : BME, 42(4), 300 - 306, Dec. 2004 , Refereed
    Summary:In recent years, the number of patients complaining of abnormal bowel movements has increased, and the incidence of abnormal bowel movements in the Japanese population over the age of 15 years old has been estimated to have increased to approximately 20%. Clarification of the intestinal peristalsis of the digestive tract is important for elucidating the pathology of digestive disorders. Existing assessment systems have problems with quantification and reproducibility. With this background, the present study was conducted to develop a system for analyzing intestinal peristalsis using three-dimensional (3D) position sensors. By creating 3D position sensors out of permanent magnets, we were able to directly measure the movements of intestinal contents and assess the state of intestinal peristalsis using strain gauges attached to the intestinal wall. The results of in vitro experiments showed that the maximum measurement error was 6.5mm within 250mm of the sensor. A preliminary animal study was conducted using wired position sensors. Radiographic findings showed that the sensors detected the movement of the intestinal contents, and the movement detected by the sensors correlated with the output of the strain gauges attached to the intestinal wall.
  • Development of noninvasive tonometer using resonance phenomenon, M. Nakai, T. Nagaoka, I. Yoshizawa, A. Fujita, S. Takeda, K. Yanasima, A. Uchiyama, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 26 III, 2055 - 2058, Dec. 2004 , Refereed
    Summary:A tonometer is used to measure ocular pressure either by shooting a short blast of compressed air onto the cornea or by applying pressure directly to the cornea. At present, the tonometer is the primary instrument available for measuring ocular pressure. However, measuring ocular pressure by such means can either frighten or injure the patient. We propose an improved method of measuring ocular pressure in which the tonometer is applied over the patient's closed eyelid for several seconds. The sensor part of the newly developed tonometer contains a bimorph type transducer and weighs only 28.7 (g). When the sensor is placed on the eyelid and the transducer is vibrated by altering the applied voltage, the current flowing through the transducer changes in relation to the ocular pressure. Ocular pressure can thus be determined based on the current flowing through the system. During measurement, patients are generally unaware of the vibrations of the sensor and report no pain.
  • Development of a small wireless position sensor for medical capsule devices, T. Nagaoka, A. Uchiyama, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 26 III, 2137 - 2140, Dec. 2004 , Refereed
    Summary:Medical capsule devices such as video capsule endoscopes are finding increasing use in clinical applications. At present, technologies capable of measuring capsule position in the digestive tract have not yet been established. The present study aims to develop a small wireless position sensor capable of measuring capsule position based on the phenomenon of mutual induction. Currents into primary coils are adjusted to maintain electromotive force induced in secondary coils at a constant level. Electromotive forces induced in the secondary coils are modulated to FM signals using an astable multivibrator, and the signals are passed directly through living tissue at low current and then demodulated by detectors on the surface of the body. A prototype wireless sensor was developed and evaluated in vitro. The sensor was capable of accurately measuring capsule position up to 500 (mm) from the primary coils with an accuracy of 5 (mm). Miniaturization of the sensor is necessary for commercialization.
  • Trial of Wireless 3-D Position Sensor, NAGAOKA Takashi, UCHIYAMA Akihiko, IEEJ Transactions on Electronics, Information and Systems, IEEJ Transactions on Electronics, Information and Systems, 124(7), 1352 - 1358, Jul. 2004 , Refereed
    Summary:We developed wireless 3-D position sensor. Although we reported a wired position sensor, in order that the wire might affect movement of the sensor, we develop a wireless position sensor newly. For inspection of position measurement algorithm, we first developed a trial product of wireless capsule type sensor without regard to size. The position of the sensor was detected by using mutual induction. In order to maintain the electromotive force induced at secondary coils in the sensor constant, the current flowing into the primary coil was regulated using feedback control. The position of the sensor was measured stably using the feedback control, even when the sensor was relatively far from the primary coil. Induced electromotive forces are modulated to FM signals by using astable multivibrator and the FM signal is flowed into a living body directly with low current, and demodulated from electrode on body surface. The position of the sensor was determined from the current flowing into the primary coil. As a result of accuracy evaluation of the sensor in vitro, the error was 2.17±0.99 mm (Ave±S.D.) in a range of up to 1 m from the magnetic field generator. This sensor is applicable to medical capsule devices, such as capsule endoscope.
  • Fabrication of Three-Dimensional Position-Measurement Sensor Using a Single-Axis Coil, Nagaoka T, Uchiyama A, Journal of Magnetics Society of Japan, Journal of Magnetics Society of Japan, 28;2(2), 97 - 101, Feb. 2004 , Refereed
    Summary:This paper proposes a new sensing method that can measure three-dimensional position inside a living body, using a magnetic field. This method is applicable to medical capsule devices, such as the capsule endoscope. The mutual induction phenomenon is used for position measurement. In order to hold constant the induced electromotive force that occurs in the secondary coil, we apply feedback control to the alternating current flowing into the primary coil. This method enables stable measurement of sensor position, even if the sensor exists relatively far from the primary coils. The position of the sensor is measured by calculating six formulas using Newton's method. The relationship between the induced electromotive force and the theoretical value of the magnetic field is determined in advance. Sensor in vitro accuracy was verified. For distances of less than 300 mm from the sensor to the magnetic field generator, the distance error was less than 7 mm. Although a wireless sensor would be ideal, the present sensor is connected to the computer through a thin cable. Development of wireless sensor should be the next research subject.
  • Development of a Three-Dimensional Position Sensor for Digestive Tract Measurement, NAGAOKA Takashi, TAKEDA Sunao, UCHIYAMA Akihiko, Transactions of the Japanese Society for Medical and Biological Engineering : BME, Transactions of the Japanese Society for Medical and Biological Engineering : BME, 41(4), 239 - 249, Dec. 2003 , Refereed
    Summary:We developed a three-dimensional position sensor that can measure the position of a capsule in the digestive tract. For the purpose of inspecting a new position measurement algorithm, we first developed a prototype wired capsule-type sensor that is capable of being swallowed. Our ultimate goal will be to develop a wireless sensor. The current sensor is applicable for medical capsule devices, such as capsule endoscope. The position of the sensor was detected using mutual induction. In order to maintain the electromotive force induced at secondary coils in the sensor constant, the current flowing into the primary coil was regulated using feedback control. The position of the sensor was measured stably using the feedback control, even when the sensor was relatively far from the primary coil. The position of the sensor was determined from the current flowing into the primary coil. As a result of evaluating the accuracy of the wired sensor in vitro, the error was 2.90 ± 2.10 mm (Ave.± S. D.) in a range of up to 1m from the magnetic field generator. Moreover, using a new position compensation algorithm, we were able to remove distortion caused by the magnetic field.
  • 3D Analysis of the Alignment of the Lower Extremity in High Tibial Osteotomy., Hideo Kawakami, Nobuhiko Sugano, Takashi Nagaoka, Keisuke Hagio, Kazuo Yonenobu, Hideki Yoshikawa, Takahiro Ochi, Asaki Hattori, Naoki Suzuki, Medical Image Computing and Computer-Assisted Intervention - MICCAI 2002, 5th International Conference, Tokyo, Japan, September 25-28, 2002, Proceedings, Part II, Medical Image Computing and Computer-Assisted Intervention - MICCAI 2002, 5th International Conference, Tokyo, Japan, September 25-28, 2002, Proceedings, Part II, 261 - 267, 2002 , Refereed
  • AI Approach of Cycle-Consistent Generative Adversarial Networks to Synthesize PET Images to Train Computer-Aided Diagnosis Algorithm for Dementia, Yuichi Kimura, Aya Watanabe, Takahiro Yamada, Shogo Watanabe, Takashi Nagaoka, Mitsutaka Nemoto, Koichi Miyazaki, Kohei Hanaoka, Hayato Kaida, Kazunari Ishii, Annals of Nuclear Medicine, Annals of Nuclear Medicine, 0(0), 0 - 0, Apr. 2020 , Refereed
    Summary:accepted on 2020/4/8. In press
  • Automatic delineation algorithm of reference region for amyloid imaging based on kinetics., Takahiro Yamada, Shogo Watanabe, Takashi Nagaoka, Mitsutaka Nemoto, Kohei Hanaoka, Hayato Kaida, Kazunari Ishii, Yuichi Kimura, Annals of nuclear medicine, Annals of nuclear medicine, 34(2), 102 - 107, Feb. 2020 , Refereed
    Summary:OBJECTIVE: This study aims to develop an algorithm named AutoRef to delineate a reference region for quantitative PET amyloid imaging. METHODS: AutoRef sets the reference region automatically using a distinguishing feature in the kinetics of reference region. This is reflected in the shapes of the tissue time activity curve. A statistical shape recognition algorithm of the gaussian mixture model is applied with considering spatial and temporal information on a reference region. We evaluate the BPND with manually set reference region and AutoRef using 86 cases (43 positive cases, 10 equivocal cases, and 33 negative cases) of dynamically scanned 11C-Pittsburgh Compound-B. RESULTS: From the Bland-Altman plot, the difference between two BPND is 0.099 ± 0.21 as standard deviation, and no significant systematic error is observed between the BPND with AutoRef and with manual definition of a reference region. Although a proportional error is detected, it is smaller than the 95% limits of agreement. Therefore, the proportional error is negligibly small. CONCLUSIONS: AutoRef presents the same performance as the manual definition of the reference region. Further, since AutoRef is more algorithmic than the ordinary manual definition of the reference region, there are few operator-oriented uncertainties in AutoRef. We thus conclude that AutoRef can be applied as an automatic delineating algorithm for the reference region in amyloid imaging.
  • Clinical contributions of exhaled volatile organic compounds in the diagnosis of lung cancer, Tsuyoshi Oguma, Takashi Nagaoka, Muneshige Kurahashi, Naofumi Kobayashi, Shinji Yamamori, Chizuko Tsuji, Hiroto Takiguchi, Kyoko Niimi, Hiromi Tomomatsu, Katsuyoshi Tomomatsu, Naoki Hayama, Takuya Aoki, Tetsuya Urano, Kazushige Magatani, Sunao Takeda, Tadashi Abe, Koichiro Asano, PLOS ONE, PLOS ONE, 12(4), e0174802, Apr. 2017 , Refereed
    Summary:Background Exhaled volatile organic compounds (VOC) are being considered as biomarkers for various lungs diseases, including cancer. However, the accurate measurement of extremely low concentrations of VOC in expired air is technically challenging. We evaluated the clinical contribution of exhaled VOC measured with a new, double cold-trap method in the diagnosis of lung cancer. Methods Breath samples were collected from 116 patients with histologically confirmed lung cancer and 37 healthy volunteers (controls) after inspiration of purified air, synthesized through a cold-trap system. The exhaled VOC, trapped in the same system, were heat extracted. We analyzed 14 VOC with gas chromatography. Results The concentrations of exhaled cyclohexane and xylene were significantly higher in patients with lung cancer than in controls (p = 0.002 and 0.0001, respectively), increased significantly with the progression of the clinical stage of cancer (both p < 0.001), and decreased significantly after successful treatment of 6 patients with small cell lung cancer (p = 0.06 and 0.03, respectively). Conclusion Measurements of exhaled VOCs by a double cold-trap method may help diagnose lung cancer and monitor its progression and regression.
  • Prospective Analyses of Volatile Organic Compounds in Obstructive Sleep Apnea Patients, Takuya Aoki, Takashi Nagaoka, Naofumi Kobayashi, Muneshige Kurahashi, Chizuko Tsuji, Hiroto Takiguchi, Katsuyoshi Tomomatsu, Tsuyoshi Oguma, Naoki Kobayashi, Kazushige Magatani, Sunao Takeda, Koichiro Asano, Tadashi Abe, TOXICOLOGICAL SCIENCES, TOXICOLOGICAL SCIENCES, 156(2), 362 - 374, Apr. 2017 , Refereed
    Summary:Various volatile organic compounds (VOCs) are known to be toxic. Although exhaled VOC patterns change in obstructive sleep apnea (OSA) patients, individual VOC profiles are not fully determined. The primary outcome was VOC characterizations; secondary outcomes included their relationships with sleep and clinical parameters in OSA patients. We prospectively examined 32 OSA patients with an apnea-hypopnea index (AHI) >= 15 by full polysomnography, and 33 age-and sex-matched controls without obvious OSA symptoms. Nine severe OSA patients were examined before and after continuous positive airway pressure (CPAP) treatment. By applying amethod which eliminates environmental VOC influences, exhaled VOCs were identified by gas chromatography (GC)-mass spectrometry, and their concentrations were determined by GC. Exhaled aromatic hydrocarbon concentrations (toluene, ethylbenzene, p-xylene, and phenylacetic acid) in the severe OSA groups (AHI >= 30) and exhaled saturated hydrocarbon concentrations (hexane, heptane, octane, nonane, and decane) in themost severe OSA group (AHI >= 60) were higher than those in the control group. Exhaled isoprene concentrations were increased in all OSA groups (AHI >= 15); acetone concentration was increased in the most severe OSA group. Ethylbenzene, p-xylene, phenylacetic acid, and nonane concentrations were increased according to OSA severity, and correlated with AHI, arousal index, and duration of percutaneous oxygen saturation (SpO(2)) <= 90%. Multiple regression analyses revealed these 4 VOC levels were associated with the duration of SpO(2) <= 90%. Isoprene and acetone decreased after CPAP treatment. OSA increased some toxic VOCs, and some correlated with OSA severity. CPAP treatment possibly ameliorates these productions.
  • Hyperspectroscopic imager for baby fibers, T. Nagaoka, A. Nakamura, T. Yamazaki, Y. Nakata, K. Endo, T. Sakaguchi, N. Kawata, T. Sota, 2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 218 - 221, 2014 , Refereed
    Summary:Hyperspectral imaging system for diagnosing digestive diseases was newly developed in order to obtain information on pathology beyond morphology of lesions. In order to guide light reflected from a lesion, a baby fiber, which can be inserted in a forceps channel of the electronic endoscope, was also developed. The performance of the system was evaluated by animal experiment. Obtained hyperspectral data were found to have sufficient quality endurable to practical use. Harmful phenomena to a living body were not observed within the experiment. It was considered from the animal experiment that the present system could be practically used for humans.
  • Hyperspectroscopic screening of melanoma on acral volar skin, Takashi Nagaoka, Atsushi Nakamura, Haruka Okutani, Yoshio Kiyohara, Hiroshi Koga, Toshiaki Saida, Takayuki Sota, SKIN RESEARCH AND TECHNOLOGY, SKIN RESEARCH AND TECHNOLOGY, 19(1), E290 - E296, Feb. 2013 , Refereed
    Summary:Background/purpose: Early detection and proper excision of the primary lesions of melanoma are crucial for reducing melanoma-related deaths. To support the early detection of melanoma, automated melanoma-screening systems have been extensively studied and developed. In this article, a previously reported hyperspectral imager and melanoma discrimination index are applied to the discrimination of acral lentiginous melanoma (ALM) from acral nevus (AN), and their diagnostic performance is reported. Methods: The index expresses the disordered nature of each lesion including variegation in color based on variation in spectral information obtained from each lesion. Performance of the index has been studied in thirteen cases of ALM and seven cases of AN, obtained from patients and volunteers, all of whom were Japanese. Results: The index discriminated ALM from AN with a sensitivity of 92% and a specificity of 86%. The area under the receiver operating characteristic curve was 0.97. Conclusion: The performance of the proposed objective melanoma discrimination index at a molecular pigmentary level approached that of clinical experts, using the three-step algorithm as the gold standard.
  • Novel automated screening of age-related macular degeneration, Yasuyuki Yamauchi, Hiroyuki Kemma, Hiroshi Goto, Atsushi Nakamura, Takashi Nagaoka, Takayuki Sota, JAPANESE JOURNAL OF OPHTHALMOLOGY, JAPANESE JOURNAL OF OPHTHALMOLOGY, 56(6), 577 - 583, Nov. 2012 , Refereed
    Summary:To determine the objective and quantitative hyperspectral parameters for distinguishing between age-related macular degeneration (AMD) and a normal macula. Near-infrared hyperspectral images were taken of 71 eyes of 62 AMD patients with exudative AMD and 21 eyes of 12 control subjects without AMD. The spatial information included a 480 x 321-pixel image in a 50A degrees field located at the ocular fundus and a 720-950-nm-per-pixel reflectance spectrum. Macular vectors were determined as the average spectrum for each macula, and reference vectors were used as average macular vectors for healthy volunteers. Variations in vector length and angle were calculated based on comparison with the reference vector. The AMD differentiation index was a parameter that minimized the plot overlap between AMD patients and controls. Statistically significant differences between the AMD patients and controls were noted. Receiver-operating characteristic curve analysis revealed an area under the curve of 0.888. The appropriate threshold values were attained for the proposed discrimination index, including 68 % sensitivity, 95 % specificity and 74 % accuracy. This study presents a simplified diagnostic index for the determination of age-related macular degeneration based on near-infrared spectra.
  • A possible melanoma discrimination index based on hyperspectral data: a pilot study, Takashi Nagaoka, Atsushi Nakamura, Haruka Okutani, Yoshio Kiyohara, Takayuki Sota, SKIN RESEARCH AND TECHNOLOGY, SKIN RESEARCH AND TECHNOLOGY, 18(3), 301 - 310, Aug. 2012 , Refereed
    Summary:Background Early detection and proper excision of the primary lesions of malignant melanoma (MM) are crucial for reducing melanoma-related deaths. To support the early detection of melanoma, automated melanoma screening systems have been extensively studied and developed. In this article, we present a hyperspectral melanoma screening system and propose a possible melanoma discrimination index derived from the characteristics of the pigment molecules in the skin, both of which have been derived from hyperspectral data (HSD). Methods The index expresses the disordered nature of each lesion including variegation in color based on variation in spectral information obtained from each lesion. Performance of the index in discriminating melanomas from other pigmented skin lesions has been studied in five cases of melanoma (41 HSD sets), one case of Spitz nevus (13 HSD sets), 10 cases of seborrheic keratosis (78 HSD sets), three cases of basal cell carcinoma (16 HSD sets), and nine cases of melanocytic nevus (21 HSD sets), obtained from patients and volunteers, all of whom were Japanese. Results Performance of the index, which reflects the disordered nature of a lesion, discriminates melanomas with a sensitivity of 90%, a specificity of 84%, and an area under the receiver operating characteristic curve of 0.93, on resubstitution. Conclusion An objective melanoma discrimination index at a molecular pigmentary level, derived from HSD, has been proposed, and its performance evaluated. This index was highly successful in discriminating MM from non-melanoma, although the statistical population was small.
  • Melanoma screening system using hyperspectral imager attached to imaging fiberscope, T. Nagaoka, A. Nakamura, Y. Kiyohara, T. Sota, 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 3728 - 3731, 2012 , Refereed
    Summary:Early detection and proper excision of the primary lesions of melanoma are crucial for reducing melanoma-related deaths. In order to support the early detection of melanoma, melanoma screening systems have been extensively studied and developed. Recently we have proposed a melanoma discrimination index derived from hyperspectral data (HSD) in the visible-near infrared wavelength region. The index represents variegation in spectra over a lesion and works well in discriminating melanoma from other pigmented lesions. However the previous hyperspectral imager did not have an enough allowance for measurement of lesions. To overcome the problem with it, we have developed a hyperspectral imager attached to imaging fiberscope. This equipment has been able to accumulate HSD in a view field of phi 40 mm within about 10 seconds, from which the above-mentioned melanoma discrimination index has been calculated. Performance of the system has been studied in nine cases of melanoma and 18 cases of non-melanoma, obtained from patients and volunteers, all of whom were Japanese. The index has achieved a sensitivity of 100 % and a specificity of 94.4 %.

Conference Activities & Talks

  • メラノーマ診断支援装置ハイパースペクトル・イメージャー(HSI)の性能 白人色素性病変の診断能力, 永岡 隆, グスタフクリステンセン, クリスチャンインバー, 清原 祥夫, 中村 厚, 宗田 孝之, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集,   2019 04
  • FDG‐PET/CTの統計的異常検知処理による転移を考慮した頸胸部病変の自動検出, 田中敦子, 根本充貴, 甲斐田勇人, 木村裕一, 永岡隆, 山田誉大, 花岡宏平, 石井一成, 日本生体医工学会大会プログラム・抄録集(Web),   2019
  • 深層畳み込みオートエンコーダを用いた健常データの教師なし学習による病変認識特徴量の汎用的自動生成, 牛房和之, 根本充貴, 木村裕一, 永岡隆, 山田誉大, 林直人, 日本生体医工学会大会プログラム・抄録集(Web),   2019
  • 皮膚のスペクトル解析とその応用, 永岡隆, 日本生体医工学会大会プログラム・抄録集(Web),   2019
  • SRTM法を用いたアミロイドイメージングに対する空間分解能を損なわないノイズ低減アルゴリズムの検討, 山田 誉大, 木村 裕一, 根本 充貴, 坂田 宗之, 永岡 隆, 花岡 宏平, 甲斐田 勇人, 石井 一成, 核医学,   2018 11
  • PETアミロイドイメージングのための空間分解能を損なわないノイズ低減アルゴリズムの臨床画像による評価, 山田誉大, 木村裕一, 藤井康介, 渡辺翔吾, 永岡隆, 根本充貴, 花岡宏平, 甲斐田勇人, 石井一成, 石井一成, 日本生体医工学会大会プログラム・抄録集(Web),   2018 06 19
  • Automatic diagnosis of melanoma using machine learning, G. Hirano, T. Nagaoka, World Congress on Medical Physics and Biomedical Engineering,   2018 06
  • メラノーマ診断支援装置ハイパースペクトル・イメージャ(HSI)の性能, 中村 厚, 清原 祥夫, 古賀 弘志, 高橋 聡, 永岡 隆, 山崎 直也, 斎田 俊明, 宗田 孝之, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集,   2018 06
  • ハイパースペクトルデータ(HSD)に基づく悪性黒色腫の腫瘍境界部の観察, 清原 祥夫, 野口 遼介, 中村 厚, 永岡 隆, 吉川 周佐, 大塚 正樹, 杉原 悟, 宗田 孝之, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集,   2018 06
  • Noise Reduction Algorithm for Amyloid Image Preserving Image Resolution. - Quantitative Evaluation Using Clinical Images -, T.Yamada, Y.Kimura, K.Fuji, S.Watanabe, T.Nagaoka, M.Nemoto, K.Hanaoka, H.Kaida, C.Hosokawa, K.Ishii, Human Amyloid Imaging Conference,   2018 01
  • ハイパースペクトラルイメージャーを用いた化粧品の定量評価に関する基礎研究, 永岡隆, 麻生祐未, 横山真由, 河本敬子, Aesthetic Dermatology,   2017 07 29
  • 化粧品のもちの定量評価―ファンデーションの時間変化―, 藤本茜, 永岡隆, 電子情報通信学会技術研究報告,   2017 01 11
  • メラノーマの診断支援システムの開発―病変部の面積が及ぼす影響―, 平野銀次, 永岡隆, 電子情報通信学会技術研究報告,   2017 01 11
  • 化粧品の主観評価とスペクトルの相関, 舩倉美咲, 永岡隆, 電子情報通信学会技術研究報告,   2017 01 11
  • Algorithm for reference region delineation for amyloid imaging using pattern recognition scheme and kinetics of administered Aβ probe ― considering the number of clusters ―, T. Yamada, Y. Kimura, T. Nagaoka, C. Hosokawa, T. Murakami, K. Ishii, Human Amyloid Imaging Conference,   2017 01
  • Investigation of Potential Usability of Machine Learning to Diagnosis of Parkinson Disease Using SPECT DaTSCAN, S. Watanabe, T. Nagaoka, Y. Kimura, International Forum on Medical Imaging in Asia (IFMIA2017),   2017 01
  • Performance Evaluation of Kinetics-Based Denoising Algorithm for PET Amyloid Imaging, K. Fuji, T. Yamada, T. Nagaoka, Y. Kimura, International Forum on Medical Imaging in Asia (IFMIA2017),   2017 01
  • Hyperspectroscopic Evaluation correlated to the Subjective Evaluation for Cosmetics, NAGAOKA Takashi, 38th Annual International Conference of the IEEE EMBS,   2016 08
  • メラノーマ診断支援装置ハイパースペクトル・イメージャーの性能~掌蹠の色素性病変~:第五報, 朴木達也, 高橋聡, 古賀弘志, 清原祥夫, 片桐孝太, 中村厚, 永岡隆, 山崎直也, 斎田俊明, 宗田孝之, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集,   2016 05 01
  • メラノーマ診断支援装置ハイパースペクトル・イメージャーの性能~腫瘍厚の推定~:第六報, 清原祥夫, 永岡隆, 中村厚, 古賀弘志, 斎田俊明, 宗田孝之, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集,   2016 05 01
  • 肺癌患者における呼気ガス中揮発性有機化合物測定の有用性の検討, 小熊剛, 永岡隆, 小林尚史, 倉橋宗重, 滝口寛人, 友松克允, 友松裕美, 新美京子, 端山直樹, 青木琢也, 浦野哲哉, 阿部直, 浅野浩一郎, 日本呼吸器学会誌,   2016 03 10
  • Algorithm for automated delineation of reference regions in PET amyloid imaging based on pattern recognition scheme and kinetics of administered tracer-Performance evaluation using climical data-, 山田誉大, 木村裕一, 永岡隆, 岡田志麻, 細川知紗, 石井一成, 電子情報通信学会技術研究報告,   2016 01 12
  • Algorithm for automated delineation of reference regions in PET amyloid imaging based on pattern recognition scheme and kinetics of administered tracer, 山田誉大, 木村裕一, 永岡隆, 岡田志麻, 細川知紗, 石井一成, 電子情報通信学会技術研究報告,   2015 11 04
  • Fiber-type hyperspectral melanoma screening system, Nagaoka T, Nakamura A, Kiyohara Y, Sota T, 37th annual international conference of the IEEE Engineering in Medicine and Biology Society,   2015 08
  • 経日に伴う潜在指紋成分の蛍光強度の増減, HIBINO KAZUTO, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, TAKEUCHI SHIGEKI, SHIMODA OSAMU, TAKATSU MASAHISA, AKIBA NORIMITSU, KUROSAWA KENJI, KUROKI KENRO, SOTA TAKAYUKI, 日本法科学技術学会誌,   2014 10 25
  • 近赤外カメラによる潜在指掌紋の顕在化~冷媒HFC152aによる前処理の効果~, NAKATSUKASA TAKUYA, SHIMODA OSAMU, SAWADA YUJI, KIMURA KOJI, KAMITA TOMOKAZU, MIURA YOSHIMASA, OGUSHI MASANORI, SAKATA MASAMICHI, TAKATSU MASAHISA, TAKEUCHI SHIGEKI, HIBINO KAZUTO, AKIBA NORIMITSU, KUROSAWA KENJI, KUROKI KENRO, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, SOTA TAKAYUKI, 日本法科学技術学会誌,   2014 10 25
  • Possible spectral separation of overlapped fingerprints, Takashi Nagaoka, Atsushi Nakamura, Hidekazu Okuda, Norimitsu Akiba, Kenro Kuroki, Kenji Kurosawa, Fumihiko Ichikawa, Akira Torao, Takayuki Sota, 22nd International Symposium on the Forensic Sciences of the Australian and New Zealand Forensic Science Society,   2014 09 03
  • ヒト呼気に含まれる揮発性有機化合物測定システムを用いた日内変動の測定, KANO SAKI, NAGAOKA TAKASHI, KOBAYASHI NAOFUMI, KURAHASHI MUNESHIGE, TAKEDA SUNAO, AOKI TAKUYA, TSUJI CHIZUKO, URANO TETSUYA, ABE TADASHI, MAGATANI KAZUSHIGE, 日本生体医工学会大会プログラム・論文集(CD-ROM),   2014 06 01
  • メラノーマ診断支援装置ハイパースペクトラル・イメージャーの性能:第三報, AOKI TOSHIYUKI, AKIYAMA SAORI, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, KOGA HIROSHI, KIYOHARA YOSHIO, SAIDA TOSHIAKI, SOTA TAKAYUKI, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集,   2014 06 01
  • ハイパースペクトラルイメーシングを用いた肌色計測による化粧品効果の評価, TOTSUKA HIRONO, NAGAOKA TAKASHI, SOTA TAKAYUKI, KIN GINSHUKU, HANAYA TSUGUO, YAMAMOTO SAWAKO, BERUMAN DAMIAN, BATISU DOMINIKU, AJURU KURISUTOFU, 日本皮膚科学会雑誌,   2014 04 15
  • Hyperspectral Imaging of Latent Fingerprints and/or Palm Prints, T. Nagaoka, A. Nakamura, H. Okuda, N. Akiba, K. Kuroki, K. Kurosawa, F. Ichikawa, A. Torao, T. Sota, 66th Annual Meeting of the AAFS, Seatle, USA,   2014 02 01
  • System improvements for exhaled breath measurement system, S. Kanou, S. Iitsuka, T. Nagaoka, N. Kobayashi, M. Kurahashi, S. Takeda, T. Aoki, C. Tsuji, T. Urano, T. Abe, K. Magatani, IFMBE Proceedings,   2014 01 01
    Summary:© Springer International Publishing Switzerland 2014. As many as 200 kinds of volatile organic compounds (VOCs) are included in human exhaled breath. Many papers using VOCs as a biomarker of respiratory diseases have been reported. However, it is very difficult to measure very low concentration of VOCs in exhaled breath with high precision. Moreover, it is also difficult to distinguish VOCs in exhaled breath and VOCs in atmosphere. Therefore, measurement of VOCs is rarely used in a clinical field because complicated and large-sized system is required for measure VOCs in exhaled breath. We are developing exhaled breath measurement system which overcame these problems. Our system analyzes exhaled breath discharged from living body by inhaling atmosphere from which VOCs were removed. In this paper, results of system improvements are reported. At first, we adopted a cold trap method with dry ice as a method of purifying atmosphere (method A). Method A needs complicated device and long processing time. Next, we changed the method into solid absorbent from method A (method B). We verified purity of purified air. Concentration of 10 kinds of VOCs contained in both exhaled breath and atmosphere were measured. Selected VOCs are as follows: benzene, cyclohexane, ethylbenzene, heptanes, hexane, isoprene, nonane, octane, toluene and xylene. Atmosphere was purified by the method A and B. Concentrations of VOCs contained in the purified air were measured by gas chromatography. As a result of measurement, almost VOCs were not detected in the purified air made by both methods. Furthermore, time to make purified air was reduced from 70 minutes to 10 minutes. Simplification of the system and shorter processing time than method A were realized by method B while keeping purity.
  • 高出力グリーンレーザによる潜在指掌紋の顕在化(第3報)~潜在指紋成分の蛍光とバックグラウンド蛍光との関係~, HIBINO KAZUTO, TAKEUCHI SHIGEKI, SHIMODA OSAMU, TAKATSU MASAHISA, AKIBA NORIMITSU, KUROSAWA KENJI, KUROKI KENRO, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, SOTA TAKAYUKI, 日本法科学技術学会誌,   2013 10 25
  • Hyperspectroscopic screening of melanoma, T. Nagaoka, A. Nakamura, Y. Kiyohara, H. Koga, T. Saida, T. Sota, 8th World Congress of Melanoma, Hamburg, Germany,   2013 07 01
  • 睡眠時無呼吸症候群患者における呼気中の揮発性有機化合物濃度の検討, AOKI TAKUYA, NAGAOKA TAKASHI, KURAHASHI MUNESHIGE, KOBAYASHI HISASHI, YAMAMORI SHINJI, IIZUKA SHINJIRO, TAKIGUCHI HIROTO, TOMOMATSU HIROMI, TOMOMATSU KATSUIN, NIIMI KYOKO, HAYAMA NAOKI, OGUMA TSUYOSHI, URANO TETSUYA, TSUJI CHIZUKO, TAKEDA SUNAO, MAGATANI KAZUSHIGE, ASANO KOICHIRO, ABE TADASHI, 呼吸,   2013 05 15
  • 肺癌患者における呼気ガス中の揮発性有機化合物の検討, OGUMA TAKESHI, ASANO KOICHIRO, NAGAOKA TAKASHI, KOBAYASHI HISASHI, TAKIGUCHI HIROTO, TOMOMATSU KATSUYOSHI, TOMOMATSU YUMI, NIIMI KYOKO, HAYAMA NAOKI, AOKI TAKUYA, URANO TETSUYA, ABE TADASHI, 日本呼吸器学会誌,   2013 03 10
  • 睡眠時無呼吸症候群における無呼吸低呼吸指数と呼気中の揮発性有機化合物の関連, AOKI TAKUYA, NAGAOKA TAKASHI, KURAHASHI MUNESHIGE, KOBAYASHI HISASHI, YAMAMORI SHINJI, IIZUKA SHINJIRO, TAKIGUCHI HIROTO, TOMOMATSU YUMI, TOMOMATSU KATSUYOSHI, NIIMI KYOKO, HAYAMA NAOKI, OGUMA TSUYOSHI, URANO TETSUYA, TSUJI CHIZUKO, TAKEDA SUNAO, MAGATANI KAZUSHIGE, ASANO KOICHIRO, ABE TADASHI, 日本呼吸器学会誌,   2013 03 10
  • メラノーマ診断支援装置ハイパースペクトラル・イメージャーの性能:第二報, AKIYAMA SAORI, KIYOHARA YOSHIO, KOGA HIROSHI, YAMAGUCHI ASATO, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, SAIDA TOSHIAKI, SOTA TAKAYUKI, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集,   2013
  • Subclinical extension of morphea-like basal cell carcinoma: hyperspectral evaluation, T. Nagaoka, Y. Kiyohara, A. Nakamura, A. Yamaguchi, T. Sota, Dermatol Pract Concept., Brisbane, Australia,   2012 04 01
  • 睡眠時無呼吸症候群患者における呼気中の揮発性有機化合物の検討, AOKI TAKUYA, NAGAOKA TAKASHI, KOBAYASHI HISASHI, KURAHASHI MUNESHIGE, YAMAMORI SHINJI, IIZUKA SHINJIRO, KATO SAKURAKO, HAYAMA NAOKI, URANO TETSUYA, TSUJI CHIZUKO, TAKEDA SUNAO, MAGATANI KAZUSHIGE, ABE TADASHI, 日本呼吸器学会誌,   2012 03 10
  • 喫煙習慣による呼気ガスの揮発性有機化合物の変化, IITSUKA SHINJIRO, NAGAOKA TAKASHI, KOBAYASHI NAOFUMI, KURAHASHI MUNESHIGE, TAKEDA SUNAO, AOKI TAKUYA, TSUJI CHIZUKO, URANO TETSUYA, ABE TADASHI, MAGATANI KAZUSHIGE, 日本生体医工学会大会プログラム・論文集(CD-ROM),   2012
  • ハイパースペクトルイメージャを用いたメラノーマの自動診断−第3報−, 永岡 隆, 中村 厚, 山口麻人, 清原祥夫, 宗田孝之, 第12回計測自動制御学会 システムインテグレーション部門講演会(SI2011),   2011 12 01
  • 足底に発生したメラノーマの自動鑑別, 永岡 隆, 中村 厚, 奥谷 悠, 清原祥夫, 古賀弘志, 斎田俊明, 宗田孝之, 第27回日本皮膚悪性腫瘍学会学術大会,   2011 06 01
  • 呼気ガス中の極微量の揮発性有機化合物(VOC:Volatile Organic Compounds)の基礎的検討, HISADA JUN'ICHIRO, AOKI TAKUYA, KOBAYASHI HISASHI, NAGAOKA TAKASHI, YAMAMORI SHINJI, INAMURA MASANORI, ISHII HIROSHI, KATO SAKURAKO, HAYAMA NAOKI, URANO TETSUYA, TAKEDA SUNAO, ABE TADASHI, 日本呼吸器学会雑誌,   2011 03 10
  • ハイパースペクトルイメージャーを用いたメラノーマの自動診断−第2報−, 永岡 隆, 中村 厚, 奥谷 悠, 清原祥夫, 宗田孝之, 第11回計測自動制御学会 システムインテグレーション部門講演会(SI2010),   2010 12 01
  • ハイパースペクトルデータに基づくメラノーマの新しい非侵襲的診断法の開発, 奥谷 悠, 中村 厚, 永岡 隆, 清原祥夫, 宗田孝之, 第23回日本色素細胞学会学術大会,   2010 11 01
  • メラノーマの新しい非侵襲的診断法の開発〜ハイパースペクトルデータ(HSD)に基づくメラノーマ鑑別指標〜, 奥谷 悠, 永岡 隆, 中村 厚, 清原祥夫, 宗田孝之, 第26回日本皮膚悪性腫瘍学会学術大会,   2010 06 01
  • メラノーマの新しい非侵襲的診断法の開発〜ハイパースペクトルイメージャ(HSI)によるメラノーマの診断〜, 清原祥夫, 奥谷 悠, 永岡 隆, 中村 厚, 宗田孝之, 第26回日本皮膚悪性腫瘍学会学術大会,   2010 06 01
  • A noble melanoma discrimination index based on hyperspectral data, H. Okutani, T. Nagaoka, A. Nakamura, Y. Kiyohara, T. Sota, 21st European Association for Cancer Research Congress, Oslo, Norway,   2010 06 01
  • ハイパースペクトルカメラを用いたメラノーマの自動診断, 永岡 隆, 中村 厚, 奥谷 悠, 會沢勝夫, 大坪真也, 清原祥夫, 宗田孝之,   2009 12 01
  • 悪性黒色腫の機械診断:可能性試験, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, OKUTANI HARUKA, AIZAWA KATSUO, OTSUBO SHIN'YA, KIYOHARA YOSHIO, SOTA TAKAYUKI, 応用物理学会学術講演会講演予稿集,   2009 09 08
  • 悪性黒色腫診断支援画像, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, OTSUBO SHIN'YA, AIZAWA KATSUO, KIYOHARA YOSHIO, SOTA TAKAYUKI, 応用物理学会学術講演会講演予稿集,   2009 09 08
  • Optical Diagnostics System of Melanoma based on Hyperspectral Imaging Technique, A. Nakamura, T. Nagaoka, S. Ohtsubo, K. Aizawa, Y. Kiyohara, T. Sota, 7th World Congress on Melanoma, Vienna, Austria,   2009 05 01
  • Melanoma Discrimination Index derived from Optical Spectra, T. Nagaoka, A. Nakamura, K. Aizawa, S. Ohtsubo, Y. Kiyohara, T. Sota, 7th World Congress on Melanoma, Vienna, Austria,   2009 05 01
  • 色素性病変診断のためのメラニン量分布画像, NAKAMURA ATSUSHI, NOMURA MASAHIRO, SUZUKI ASAYOSHI, OSATO NAO, MATSUMURA AZUSA, OTSUBO SHIN'YA, AIZAWA KATSUO, SOTA TAKAYUKI, NAGAOKA TAKASHI, FURUKAWA MASAYO, KIYOHARA YOSHIO, ITO SHOSUKE, WAKAMATSU KAZUMASA, 日本皮膚科学会雑誌,   2009 04 20
  • 色素性病変診断に向けたメラニン,ヘモグロビン濃度強調マップの作製, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, OTSUBO SHIN'YA, AIZAWA KATSUO, KIYOHARA YOSHIO, SOTA TAKAYUKI, 日本皮膚科学会雑誌,   2009 03 25
  • Automated Melanoma Recognition using Hyperspectral Image Analysis, T. Nagaoka, International Workshop HITS 2009, Tokyo Institute of Technology, Tokyo, Japan,   2009 02 01 , 招待有り
  • ハイパースペクトルカメラを用いた悪性黒色腫の自動診断, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, AIZAWA KATSUO, OTSUBO SHIN'YA, MOCHIZUKI TOORU, KIYOHARA YOSHIO, SOTA TAKAYUKI, 日本生体医工学会大会プログラム・論文集(CD-ROM),   2009
  • 多層モデルによる皮膚の分光特性推定, 永岡 隆, 清原祥夫, 中村 厚, 野村将大, 鈴木麻悌, 大里奈央, 松村あずさ, 大坪真也, 會沢勝夫, 宗田孝之, 古川雅代, 伊藤祥輔, 若松一雅, 第9回計測自動制御学会システムインテグレーション部門講演会(SI2008),   2008 12 01
  • 3次元皮膚モデルを用いたメラニン濃度分布の画像化, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, FURUKAWA MASAYO, NOMURA MASAHIRO, SUZUKI ASAYOSHI, OSATO NAO, MATSUMURA AZUSA, OTSUBO SHIN'YA, AIZAWA KATSUO, KIYOHARA YOSHIO, ITO SHOSUKE, WAKAMATSU KAZUMASA, SOTA TAKAYUKI, 応用物理学会学術講演会講演予稿集,   2008 09 02
  • 3次元皮膚モデルの光学的特性, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, FURUKAWA MASAYO, NOMURA MASAHIRO, SUZUKI ASAYOSHI, OSATO NAO, MATSUMURA AZUSA, OTSUBO SHIN'YA, AIZAWA KATSUO, KIYOHARA YOSHIO, ITO SHOSUKE, WAKAMATSU KAZUMASA, SOTA TAKAYUKI, 応用物理学会学術講演会講演予稿集,   2008 09 02
  • 眼底スペクトル画像に対するリング照明に起因した照明ムラの除去, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, SOTA TAKAYUKI, AIZAWA KATSUO, OTSUBO SHIN'YA, 日本糖尿病眼学会誌,   2008 04 28
  • 近赤外光を用いた眼底スペクトル撮像装置の開発, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, SOTA TAKAYUKI, AIZAWA KATSUO, ICHIKAWA FUMIHIKO, KANAZAWA MASAO, KEZUKA TAKESHI, SHIRAI MASAHIKO, 日本糖尿病眼学会誌,   2008 04 28
  • 近赤外眼底分光画像に関するリング状照明モデルによる輝度値補正, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, NOMURA MASAHIRO, OTSUBO SHIN'YA, AIZAWA KATSUO, SOTA TAKAYUKI, 日本生体医工学会大会プログラム・論文集(CD-ROM),   2008
  • ハイパースペクトルカメラを用いた皮膚血行動態の観察, 永岡 隆, 清原?夫, 中村 厚, 會沢勝夫, 大坪真也, 宗田孝之, 市川文彦, 山嵜登志夫, 土居正雄, 中村勝重, 第8回システムインテグレーション部門講演会(SI2007),   2007 12 01
  • in vitro皮膚組織モデルを用いた分光学的メラニン色素濃度定量法の検討, NAKAMURA ATSUSHI, TANIGAWA SAYAKA, FURUKAWA MASAYO, AIZAWA KATSUO, NAGAOKA TAKASHI, OTSUBO SHIN'YA, WAKAMATSU KAZUMASA, ITO SHOSUKE, SOTA TAKAYUKI, 応用物理学会学術講演会講演予稿集,   2007 09 04
  • Application of decorrelation stretching method to hyperspectral fundus image processing, T. Nagaoka, A. Nakamura, K. Aizawa, M. Kanazawa, T. Kezuka, M. Miura, M. Usui, S. Ohtsubo, T. Sota, Progress in Biomedical Optics and Imaging - Proceedings of SPIE,   2007 08 31
    Summary:We have developed a near-infrared hyperspectral imaging system that can acquire both spectral and spatial data covering a 50-degree field at the fundus surface within 5 seconds. Single wavelength band reflectance images with bandwidth of 20 nm have demonstrated that choroidal vascular patterns can be clearly observed as bright images for the central wavelength ranging from 740 to 860 nm, while retinal blood vessels are seen as dark images for that ranging from 740 to 920 nm. It is desirable for clinical use to separate the choroidal vascular patterns image from the retinal blood vessels image. To this end, we have applied the decorrelation stretch to processing of spectral images. We have found the following. Original fundus spectral images have stripes noise. The decorrelation stretch emphasizes the noise and, thus, the noise has to be removed by, for example, DCT (Discrete Cosine Transform) filter beforehand. The choroidal vascular image can be successfully separated from the retinal vascular image. Furthermore, the macular is superimposed on the latter as it should be so from the viewpoint of anatomy. The result suggests that useful information may be extracted by combining hyperspectral images with the decorrelation stretch.
  • Near-infrared hyperspectral images of human ocular fundus and their processing with decorrelation stretch, T. Nagaoka, A. Nakamura, K. Aizawa, M. Kanazawa, T. Kezuka, M. Miura, M. Usui, S. Ohtsubo, T. Sota, Progress in 2007 ARVO Annual Meeting "The Aging Eye", Florida, USA,   2007 05 01
  • ハイパースペクトル医用画像を用いたerythema indicesの観察, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, AIZAWA KATSUO, OTSUBO SHIN'YA, KIYOHARA YOSHIO, SOTA TAKAYUKI, 日本生体医工学会大会プログラム・論文集(CD-ROM),   2007
  • ハイパースペクトル眼底画像への非相関強調の適用, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, AIZAWA KATSUO, KANAZAWA MASAO, KEZUKA TAKESHI, MIURA MASAHIRO, USUI MASAHIKO, OTSUBO SHIN'YA, SOTA TAKAYUKI, 日本分光学会講演要旨集,   2006 11 08
  • 近赤外眼底ハイパースペクトル画像撮像装置の開発, NAKAMURA ATSUSHI, AIZAWA KATSUO, NAGAOKA TAKASHI, ICHIKAWA FUMIHIKO, KANAZAWA MASAO, KEZUKA TAKESHI, MIURA MASAHIRO, USUI MASAHIKO, SOTA TAKAYUKI, 日本分光学会講演要旨集,   2006 11 08
  • 近赤外眼底スペクトル画像撮像装置の臨床応用に向けた検討, TANGO MANABU, NAKAMURA ATSUSHI, AIZAWA KATSUO, NAGAOKA TAKASHI, KANAZAWA MASAO, KEZUKA TSUYOSHI, MIURA MASAHIRO, USUI MASAHIKO, ICHIKAWA FUMIHIKO, MUNETA TAKAYUKI, 日本レーザー医学会誌,   2006 07 15
  • 眼底スペクトル画像上でのニュートン法を用いた照明ムラ補正, KUROIWA YOHEI, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, AIZAWA KATSUO, OTSUBO SHIN'YA, SOTA TAKAYUKI, 日本生体医工学会大会プログラム・論文集,   2006 05 15
  • 近赤外眼底スペクトル画像, NAKAMURA ATSUSHI, AIZAWA KATSUO, NAGAOKA TAKASHI, ICHIKAWA FUMIHIKO, KANAZAWA MASAO, KEZUKA TAKESHI, USUI MASAHIKO, SOTA TAKAYUKI, 日本生体医工学会大会プログラム・論文集,   2006 05 15
  • 永久磁石を用いた3次元位置検出システムの開発(第4報), KUWATA EIGO, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本生体医工学会大会プログラム・論文集,   2006 05 15
  • 眼底スペクトル撮像装置を用いた糖尿病性網膜症由来浮腫の観察, TANGO MANABU, NAKAMURA ATSUSHI, AIZAWA KATSUO, NAGAOKA TAKASHI, KANAZAWA MASAO, KEZUKA TAKESHI, USUI MASAHIKO, ICHIKAWA FUMIHIKO, SOTA TAKAYUKI, 日本生体医工学会大会プログラム・論文集,   2006 05 15
  • 多波長パルス分光法による多項目血液成分無侵襲計測器の開発, SUZAKI HIRONORI, KOBAYASHI NAOKI, NAGAOKA TAKASHI, TAKEDA SUNAO, TOGAWA TATSUO, 日本生体医工学会大会プログラム・論文集,   2006 05 15
  • スペクトル画像を用いた脈絡膜血管観察, NAKAMURA ATSUSHI, NAGAOKA TAKASHI, SOTA TAKAYUKI, AIZAWA KATSUO, ICHIKAWA FUMIHIKO, KANAZAWA MASAO, KEZUKA TAKESHI, USUI MASAHIKO, 応用物理学関係連合講演会講演予稿集,   2006 03 22
  • 眼底スペクトル画像における照明系に起因した輝度値変化の補正, NAGAOKA TAKASHI, NAKAMURA ATSUSHI, SOTA TAKAYUKI, AIZAWA KATSUO, OTSUBO SHIN'YA, 応用物理学関係連合講演会講演予稿集,   2006 03 22
  • Development of a small wireless position and bleeding detection sensor, T. Nagaoka, A. Uchiyama, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology,   2005 12 01
    Summary:Medical capsule devices such as video capsule endoscopes are finding increasing use in clinical applications. At present, technologies capable of measuring capsule position and detecting a bleeding in the digestive tract at the same time have not yet been established. The present study aims to develop a small wireless position and bleeding detection sensor. The sensor position are measured by using the phenomenon of mutual induction and Newton's law. Electromotive forces induced in the sensor are modulated to FM signals using an astable multivibrator, and the signals are passed directly through living tissue at low current and then demodulated by detectors on the surface of the body. A prototype sensor was developed and evaluated in vitro. The sensor was capable of accurately measuring capsule position up to 500 (mm) from the primary coils with an accuracy of 5 (mm), and detecting 0.5 cc blood in 500 cc physiological saline. © 2005 IEEE.
  • C-10-4 Development and Evaluation of 3-D position sensor using a permanent magnet, Nagaoka Takashi, Proceedings of the Society Conference of IEICE,   2005 09 07
  • 永久磁石を用いた三次元位置センサの開発と評価, NAGAOKA TAKASHI, 電子情報通信学会大会講演論文集,   2005 09 07
  • Application of 3-D position measurement sensor using permanent magnet, ICHIKAWA Daisuke, NAGAOKA Takashi, UCHIYAMA Akihiko, TAKEDA Sunao, 電気学会研究会資料. MBE, 医用・生体工学研究会,   2005 07 19
  • Relation between hematocrit and optical density in pulse oximetry -In vitro study with Waseda mock circulatory system, H. Suzaki, N. Kobayashi, H. Kubota, T. Aomi, T. Nagaoka, K. Iwasaki, M.Umezu, S. Takeda, A. Uchiyama, 3rd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Oahu, USA,   2005 05 01
  • 運動中の心電図計測・解析システムの開発, CHIYODA SHIGEO, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会大会論文集,   2005 04 25
  • 透過波を利用した超音波断層像構築に向けた基礎研究, KUWATA EIGO, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会大会論文集,   2005 04 25
  • 永久磁石を用いた位置検出システムの開発(第三報), ICHIKAWA DAISUKE, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会大会論文集,   2005 04 25
  • 永久磁石を用いた位置検出システムの開発(第二報), ICHIKAWA DAISUKE, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会秋季大会論文集,   2004 11 05
  • 無線式カプセル型三次元位置センサの開発, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会秋季大会論文集,   2004 11 05
  • 無侵襲Co‐O xim eterの開発, SUZAKI HIRONORI, KOBAYASHI NAOKI, KUBOTA HIROSHI, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会秋季大会論文集,   2004 11 05
  • Development of wireless 3-D position sensor using magnetic field, NAGAOKA T, ICHIKAWA D, UCHIYAMA A, 日本応用磁気学会学術講演概要集 = Digest of ... annual conference on magnetics in Japan,   2004 09 21
  • 非観血血圧計測における耐ノイズ性向上に関する基礎的研究, DODA HIDENORI, USUDA TAKASHI, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会大会論文集,   2004 05 19
  • 永久磁石を用いた位置検出システムの開発, ICHIKAWA DAISUKE, NAGAOKA TAKASHI, TAKEDA SUNAO, UCHIYAMA AKIHIKO, 日本ME学会大会論文集,   2004 05 19
  • カプセル型三次元位置センサの無線化への検討, NAGAOKA TAKASHI, UCHIYAMA AKIHIKO, 日本ME学会大会論文集,   2004 05 19
  • Development of 3-D Position Sensor for capsule endoscopy, T. Nagaoka, 3rd International Conference on CAPSULE ENDOSCOPY, Miami, USA,   2004 02 01
  • 消化器官の運動や生理的現象を解析するシステムの開発, 永岡 隆, 長澤拓弥, 武田朴, 松本孝嗣, 高尾良彦, 穴澤貞夫, 内山明彦, 電気学会研究会資料(医用・生体工学研究会),   2002 10 01
  • 脛骨高位骨切り術シミュレーションのための軟組織の変形と干渉を考慮できる膝モデルの開発, 永岡 隆, 川上秀夫, 米延策雄, 菅野伸彦, 萩尾圭介, 吉川秀樹, 越智隆弘, 服部麻木, 鈴木直樹, 第41回日本ME学会大会,   2002 05 01
  • New Three-Dimensional Endoscopic Sonograph Using Electo-Magnetic Tracking System, SUMIYAMA K, SUZUKI N, HATTORI A, KOIZUMI N, NAGAOKA T, UCHIYAMA Y, IKEDA K, KAKUTANI H, TAJIRI H, AOKI T, Journal of Japan Society of Computer Aided Surgery : J.JSCAS,   2001 12 30
  • Assesment of A Surgical Planning for High Tibial Osteotomy using a 3D Simulation Program, KAWAKAMI Hideo, SUGANO Nobuhiko, HAGIO Keisuke, YONENOBU Kazuo, YOSHIKAWA Hideki, OCHI Takahiro, NAGAOKA Takashi, HATTORI Asaki, SUZUKI Naoki, Journal of Japan Society of Computer Aided Surgery : J.JSCAS,   2001 12 30
  • Development of Simulation System for High Tibia Osteotomy Using Muscle and Tendon Model, NAGAOKA T, KAWAKAMI H, YONENOBU S, SUGANO N, HAGIO K, YOSHIKAWA H, OCHI T, HATTORI A, SUZUKI N, Journal of Japan Society of Computer Aided Surgery : J.JSCAS,   2001 12 30
  • The Development of Diagnosis Support System using 4D Imaging and VR Environment, T.Nagaoka, N.Suzuki, A.Hattori, Richard A.Robb, K.Sumiyama, N.Koizumi, A.Uchiyama, The 5th World Multiconference on Systemics, Cybernetics and Informatics SCI, Florida, USA,   2001 08 01
  • 四次元画像診断支援システムの開発, 永岡 隆, 鈴木直樹, 服部麻木, Richard A.Robb, 炭山和毅, 小泉直史, 内山明彦, 第40回日本ME学会大会,   2001 05 01
  • コンベックス走査式超音波内視鏡により得た超音波三次元データセットの表示法の開発, 小泉直史, 炭山和毅, 青木照明, 鈴木直樹, 服部麻木, 永岡 隆, 内山明彦, 第40回日本ME学会大会,   2001 05 01
  • The Development of Visualization Method for Four-Dimensional Image Using VR Environment, NAGAOKA T, SUZUKI N, HATTORI A, ROBB Richard A, SUMIYAMA K, UCHIYAMA A, Journal of Japan Society of Computer Aided Surgery : J.JSCAS,   2000 12 30
  • New Three Dimensional Endoscopic Ultrasound Systems with Convex Scanning Echoendoscopes, SUMIYAMA K, SUZUKI N, HATTORI A, KOIZUMI N, NAGAOKA T, HINO S, SUZUKI H, AOKI T, Journal of Japan Society of Computer Aided Surgery : J.JSCAS,   2000 12 30
  • 四次元CTデータセット可視化のための表示システムの開発, 永岡 隆, 鈴木直樹, 服部麻木, 松下 聡, 高津光洋, 内山明彦, 第39回日本ME学会大会,   2000 05 01

Misc

  • Performance Evaluation of Noise Reduction Algorithm for PET Amyloid Imaging Using Clinical Images., Yamada Takahiro, Kimura Yuichi, Fujii kosuke, Watanabe Shogo, Nagaoka Takashi, Nemoto Mitsutaka, Hanaoka Kohei, Kaida Hayato, Ishii Kazunari, Transactions of Japanese Society for Medical and Biological Engineering, 56, 0, S294, S294,   2018 , http://ci.nii.ac.jp/naid/130007483802
    Summary:<p>This study aims to develop a noise reduction algorithm for amyloid PET imaging. A visualization of a small amyloid-β (Aβ) deposit is required for early diagnosis of Alzheimer's disease (AD) pathology, and a noise in amyloid image should be reduced without any loss of spatial resolution. Conventional noise reduction algorithms use spatial averaging, but our proposed algorithm, CAKS, averages pixels that have similar kinetics of administered PET radiopharmaceutical. As a result of CAKS applying to actual clinical images, the noise is reduced and the image quality is improved. The contrast between gray and white matters is significantly improved (p<.05). We concluded that CAKS is applied to clinical amyloid PET imaging is useful for diagnosis of AD pathology. </p>
  • Development of automated delineation algorithm of reference regions for amyloid imaging. - Considering time information and the number of clusters -, Yamada Takahiro, Kimura Yuichi, Nagaoka Takashi, Hanaoka Kohei, Hosokawa Chisa, Ishii Kazunari, Trans. jpn. Soc. Med. Bio. Eng, 55, 4, 281, 281,   2017 , http://ci.nii.ac.jp/naid/130006077023
    Summary:<p>In Alzheimer's disease (AD) amyloid-β (Aβ) depositions disturbs neurons irreversibly, and early treatment before occurrence of dementia is important for AD treatments. This study aims at proposing an automated delineation algorithm for reference regions (AutoRef) for Aβ accumulation quantification. This presentation focuses on merits of a limited temporal information and the increased number clusters. As a result, for 86 clinical data (43 cases of AD, 33 cases of normal and 10 cases of equivocal deposition of Aβ), AutoRef succeeded in delineating the reference region for all the data. There was no significant difference (p < 0.05) between AutoRef and manually delineated reference region by a physician. The standard deviation of the difference between them was smaller than the discrimination threshold of AD used in actual clinical practice. In conclusions, the effectiveness of this study was suggested.</p>
  • 睡眠時無呼吸症候群患者における呼気中の揮発性有機化合物濃度の検討, 青木 琢也, 永岡 隆, 倉橋 宗重, 小林 尚史, 山森 伸二, 飯塚 慎二郎, 滝口 寛人, 友松 裕美, 友松 克允, 新美 京子, 端山 直樹, 小熊 剛, 浦野 哲哉, 辻 千鶴子, 武田 朴, 曲谷 一成, 浅野 浩一郎, 阿部 直, 呼吸, 32, 5, 482, 482,   2013 05
  • 睡眠呼吸障害 睡眠時無呼吸症候群における無呼吸低呼吸指数と呼気中の揮発性有機化合物の関連, 青木 琢也, 永岡 隆, 倉橋 宗重, 小林 尚史, 山森 伸二, 飯塚 慎二郎, 滝口 寛人, 友松 裕美, 友松 克允, 新美 京子, 端山 直樹, 小熊 剛, 浦野 哲哉, 辻 千鶴子, 武田 朴, 曲谷 一成, 浅野 浩一郎, 阿部 直, 日本呼吸器学会誌, 2, 増刊, 142, 142,   2013 03
  • 肺癌患者における呼気ガス中の揮発性有機化合物の検討, 小熊 剛, 浅野 浩一郎, 永岡 隆, 小林 尚史, 滝口 寛人, 友松 克允, 友松 裕美, 新美 京子, 端山 直樹, 青木 琢也, 浦野 哲哉, 阿部 直, 日本呼吸器学会誌, 2, 増刊, 208, 208,   2013 03
  • がんの超早期診断に資するマルチスペクトルカメラの開発, NAGAOKA TAKASHI, 中谷電子計測技術振興財団年報, 24, 92, 103,   2010 08 20 , http://jglobal.jst.go.jp/detail.php?from=API&JGLOBAL_ID=201002218077992608
  • 表在性腫瘍や血管障害を診断することができるマルチスペクトルカメラの開発とその表示法の開発, NAGAOKA TAKASHI, MOCHIZUKI TOORU, SOTA TAKAYUKI, NAKAMURA ATSUSHI, 村田学術振興財団年報, 21, 370, 378,   2007 12 , http://jglobal.jst.go.jp/detail.php?from=API&JGLOBAL_ID=200902292041107734
  • カプセル型医用機器等の生体内位置計測に適した小型位置センサの開発とその応用, NAGAOKA TAKASHI, UCHIYAMA AKIHIKO, TAKEDA SUNAO, マツダ財団研究報告書(科学技術振興関係), 19, 39, 42,   2007 06 , http://jglobal.jst.go.jp/detail.php?from=API&JGLOBAL_ID=200902282710216794
  • 永久磁石を用いた生体内三次元位置センサの開発とその応用, NAGAOKA TAKASHI, UCHIYAMA AKIHIKO, 立石科学技術振興財団助成研究成果集, 15, 52, 55,   2006 09 , http://jglobal.jst.go.jp/detail.php?from=API&JGLOBAL_ID=201102240735563964
  • カプセル内視鏡などのカプセル型生体計測機器に適した三次元位置計測センサの開発とセンサを用いた腸ぜん動運動機能の計測, NAGAOKA TAKASHI, 医科学応用研究財団研究報告, 23, 72, 77,   2006 02 , http://jglobal.jst.go.jp/detail.php?from=API&JGLOBAL_ID=200902234485413327

Research Grants & Projects

  • Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(若手研究(B)), Cancer diagnostic system using hyperspectral imaging technique, Cancer diagnostic system using hyperspectral imaging technique was newly developed. In paticular, melanoma diagnosis support system suitable for clinical field was newly developed and its practicality was verifyed. The system succeed in collecting the 200 cases without a trouble and achieved high accuracy (over 90% in sensitivity and specificity). Hyperspectral imaging system for endscopy was also developed and verifyed by animal experiment. It was confirmed that the system can measure spectra in a digestive tract. Clinical test in Swedish area is planned from now on aiming at the global launch of the melanoma diagnosis device.
  • Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(若手研究(A)), A hyperspectral melanoma screening system
  • The Other Research Programs, -