KINDAI UNIVERSITY


*A space between the first name and last name, please enter

OKADA Yoshiharu

Profile

FacultyDepartment of Biotechnology and Chemistry / Graduate School of System Enginnering
PositionAssociate Professor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/346-okada-yoshiharu.html
URL
Mail
Last Updated :2020/09/14

Education and Career

Education

  •  - 1982 , Kyushu Institute of Technology, School of Engineering
  •  - 1982 , Kyushu Institute of Technology, Faculty of Engineering

Academic & Professional Experience

  •   2013 04 ,  - 現在, Faculty of Engineering, Department of Biotechnology and Chemistry , Kindai University
  •   2007 04 ,  - 2013 03 , Faculty of Engineering, Kindai University
  •   2003 04 ,  - 2007 03 , Faculty of Engineering, Kindai University
  •   1995 ,  - 2003 , Faculty of Engineering, Kindai University
  •   1993 ,  - 1995 , Kyushu Institute of Technology
  •   1993 ,  - 1995 , Kyushu Institute of Technology, Research
  • Assistant

Research Activities

Research Areas

  • Nanotechnology/Materials, Synthetic organic chemistry
  • Life sciences, Bioorganic chemistry
  • Nanotechnology/Materials, Structural/physical organic chemistry

Research Interests

  • Asymmetric Synthesis

Published Papers

  • Convenient Synthesis and Physiological Activities of Flavonoids in Coreopsis lanceolata L. Petals and Their Related Compounds, OKADA Yoshiharu, Molecules, Molecules, 23(7), 1671, Jul. 2018 , Refereed
  • Convenient Synthesis of 1-(Trimethylsilyl)- and 1-(Trimethylstannyl)Vinylphosphonates and Their Synthetic Application, Yoshiharu Okada, Riho Urushihara, Masato Nakamoto, PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 190(5-6), 922 - 924, Jun. 2015 , Refereed
    Summary:Dimethyl 1,1-bis(trimethylsilyl)methylphosphonate was succeeded to react with aromatic aldehydes in the presence of methyl benzoate as additive to give the corresponding vinylphosphonates in moderate yields. Michael addition and subsequent Peterson olefination reaction of dimethyl (Z)-2-(3,4-methylenedioxyphenyl)-1-(trimethylsilyl)vinylphosphonate with 3,4,5-trimethoxyphenyllithium and crotonaldehyde afforded the corresponding (2E,4E)-1-(3,4,5-trimethoxyphenyl)-1-(3,4-methylenedioxyphenyl)-2-(dimethylphosphono)hexa-2,4-diene in 36% yield.
  • Isolation and identification of flavonoids from Coreopsis lanceolata L. petals, Yoshiharu Okada, Mari Okita, Yoshihiro Murai, Yuka Okano, Masato Nomura, NATURAL PRODUCT RESEARCH, NATURAL PRODUCT RESEARCH, 28(3), 201 - 204, Feb. 2014 , Refereed
    Summary:The methanol extract of Coreopsis lanceolata L. petals was acid-hydrolysed, and 7,3,4-trihydroxy-8-methoxyflavanone (1) and 6,3,4-trihydroxy-7-methoxyaurone (leptosidin) (2) were successfully isolated. The structure of compound 1 is designated to flavanone based on X-ray crystallographic analysis and NMR spectroscopic analysis. Compound 1 showed high-antioxidant effects based on diphenylpicrylhydrazyl radical scavenging assay (94.3% scavenging rate) and superoxide dismutase-like activity assay (23.9% inhibition rate).
  • CONVENIENT SYNTHESIS OF 1-(TRIMETHYLSILYL)- AND 1-(TRIMETHYLSTANNYL)VINYLPHOSPHONATES, Yoshiharu Okada, Tomohiro Maruyama, Shin-ichi Tamura, Hirohito Kameoka, Satoshi Masuda, Yuichiro Tokuda, Junya Sakai, Masato Nomura, PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 189(6), 778 - 790, 2014 , Refereed
    Summary:Dimethyl 1,1-bis(trimethylsilyl)methylphosphonate and dimethyl 1-(trimethylsilyl)-1-(trimethylstannyl)methylphosphonate were succeeded to react with aromatic aldehydes in the presence of methyl benzoate as additive to give the corresponding vinylphosphonates in moderate yields.
  • A Study on Fatty Acids in Seeds of Euterpe oleracea Mart Seeds, Yoshiharu Okada, Tomoyuki Motoya, Shinichi Tanimoto, Masato Nomura, JOURNAL OF OLEO SCIENCE, JOURNAL OF OLEO SCIENCE, 60(9), 463 - 467, Sep. 2011
    Summary:Fatty acids of Euterpe oleracea Mart seeds were analyzed in hexane and diethyl ether extracts. The hexane extract contained dodecanoic acid (3), tetradecanoic acid (4), hexadecanoic acid (7), and 9-octadecenoic acid (10). The diethyl ether extract contained (10). The oil of Mart seeds was obtained firstly by methanol extract and further extracted with diethyl ether. The hexane and diethyl ether extracts were then analyzed for antioxidant effects. Both extracts demonstrated a 1,1-diphenyl-2-picrylhydrazyl radical elimination effect similar to that of alpha-tocopherol and an active oxygen inhibition effect. Significant quantities (0.6212 mg/mL) of poly phenol, in comparison to the standard rejected gallic acid, were found in the extract oil of Mart seeds by the methanol extraction.
  • Effect of impregnation using sucrose solution on stability of anthocyanin in strawberry jam, Yoshiyuki Watanabe, Kazunori Yoshimoto, Yoshiharu Okada, Masato Nomura, LWT-FOOD SCIENCE AND TECHNOLOGY, LWT-FOOD SCIENCE AND TECHNOLOGY, 44(4), 891 - 895, May 2011
    Summary:Strawberry impregnated with sucrose was used for the jam preparation, and its effects on the stability of anthocyanins and the jam color were examined. The amount of sucrose in impregnated strawberry depended on the concentration of sucrose solution and the operation time for the impregnation. In comparison with only the addition of sucrose to the jam preparation, the impregnation of strawberry in advance of the jam preparation stabilized anthocyanins in the jam. The antioxidative ability of the strawberry jam correlated with the amount of anthocyanin. Furthermore, the rate constants by the Weibull model for the degradation of anthocyanins and the chromatic deterioration of the jam were estimated, and the relationship between the two rate constants was found to be almost linear. It was shown that the impregnation of strawberry with sucrose was effective for improving functions, such as antioxidative activity and the color of its jam. (C) 2010 Elsevier Ltd. All rights reserved.

Conference Activities & Talks

  • Synthesis of Brachydin B and Its Analogues, YAMAMOTO Takaya, SASAJIMA Ami, OKADA Yoshiharu,   2019 03 18
  • Simple Synthesis and Physiological Activities of Acerogenins, Mayu Okamura, Masato Nakamoto, Yoshiharu Okada, 17th Tetrahedron Symposium,   2016 06 29
  • Isolation of Flavonoids in Coreopsis lanceolata L. Petals and Their Synthesis with β-Ketophosphonates,   2013 03
  • Convenient Synthesis of 3-(Dialkylphosphono)chroman-2- and 4-ones, IUPAC,   2009 08 , IUPAC

Misc

  • Synthesis of a Novel Type of a-Phosphonocyclobutanones Using Rh(II)-Catalyzed C-H Insertion Reaction, Research reports of the School of Engineering, Kinki University, 37, 49, 52,   2003 12
  • Skin Whitening Effects of Estragole Derivatives, J. Oleo Sci., 52 (9), 495-498,   2003 , 10.5650/jos.52.495
  • Synthesis of Phosphine Oxide-Carboxylic Acid Esters Bearing 9,10-Dihydro-9,10-ethanoanthracene Moiety, Phosphorus, Sulhur, and Silicon, and the Related Elements, 178 (4), 821-829,   2003 , 10.1080/10426500307810
  • Synthesis of Chiral 3-(o-Diphenylphosphinophenyl)-Butanoic Acid and Its Palladium Complex Catalyzed Asymmetric Allylic Alkylation, Phosphorus, Sulfur, and Silicon, and the Related Elements, 177(8-9), 1973,   2002 , 10.1080/10426500213317
  • Construction of αーPhosphonolactams via Rhodium(II)-Catalyzed Intramolecular C-H Insertion Reaction (共著), Heteroatom Chemistry, 6 (3), 195-210,   1995 , 10.1002/hc.520060304
  • Development of Chiral Phosphine Ligands Bearing A Carboxyl Group and Their Application to Catalytic Asymmetric Reaction (共著), Tetrahedron:Asymmetry, 6 (10), 2469-2474,   1995 , 10.1016/0957-4166(95)00322-G
  • Intramolecular Ene Reaction of Vinylphosphonates. Synthetic Application to Bicyclic Compounds, and Cadalane and Valerenic Acid Terpenoids (共著), The Journal Organic Chemistry, 59 (22), 6717-6727,   1994 , 10.1021/jo00101a034
  • Copper(I)Salt-Mediated Arylaiton of Phosphinyl-Stabilized Carbanions and Synthetic Application to Heterocyclic Compounds (共著), The Journal Organic Chemistry, 58 (25), 7009-7015,   1993 , 10.1021/jo00077a018
  • A Novel Type of Chiral Diphosphine Ligand, trans-2,3-Bis(diphenylphosphino)-1-methyl-1-cyclopropanecarboxylic Acid and Asymmetric Allyic Alkylation by the Use of Its Palladium Complex (共著), Phosphorus, Sulfur, and Silicon, 77, 153,   1993
  • A Novel Type of Chiral Diphosphine Ligand, trans-2,3-Bis(diphenylphosphino)-1-methyl-1-cyclopropanecarboxylic Acid and Asymmetric Alkylation by the Use of Its Palladium Complex (共著), Chemistry Letters, 1992 (4), 547-550,   1992 , 10.1246/cl.1992.547
  • Synthesis of Novel Type of Chiral Phosphinocarboxylic Acids. The Phosphine-Palladium Complexes Catalyzed Asymmetric Allylic Alkylation (共著), Tetrahedron : Asymmetry, 2 (7), 667-682,   1991 , 10.1016/S0957-4166(00)86121-2
  • The Fiest Synthesis of Chiral Phosphinocarboxylic Acid Ligands, trans-2-(Diphenyl-phosphino)cycloalkanecarboxylic Acids. The Phosphine-Palladium Complexes Catalyzed Asymmetric Allylic Alkylation (共著), Tetrahedron Letters, 31 (27), 3905-3908,   1990 , 10.1016/S0040-4039(00)97502-6
  • Synthesis and Reaction of (3-Phenylseleno-1-alkenyl)triphenylphosphonium Salts (共著), Chemistry Letters, 1989 (10), 1741-1742,   1989 , 10.1246/cl.1989.1741
  • [Cycloakyl(phenylseleno)methylene]triphenylphosphoranes : Synthesis and Reactions of (Phenylseleno)alkenes (共著), Bulletin of the Chemical Society of Japan, 62 (11), 3724-3726,   1989 , 10.1246/bcsj.62.3724
  • New Synthesis of Cyclobutane Annelated Compounds by the Use of a (1-Cyclobutenyl)triphenylphosphonium Salt (共著), The Journal Organic Chemistry, 54 (4), 974-977,   1989 , 10.1021/jo00265a047
  • Synthesis and Resolution of a New Type of Chiral Bisphosphine Ligand, trans-Bis-1,2-(diphenylphosphino)cyclobutane, and Asymmetric Hydrogenation Using Its Rhodium Complex (共著), Chemistry Letters, 1986 (4), 613-616,   1986 , 10.1246/cl.1986.613

Research Grants & Projects

  • Study on Catalytic Asymmetric Synthesis Using Optically Active Transition Metal Complexes
  • Development of Chiral Phosphine Ligands