Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2014/04 -2017/03
Author : SUZUKI Toshio
The solubility improvement of hydroxycinnamic acids was investigated with beta-1,3-1,6-glucan from Aureobasidium pullulans. As a model compound, p-coumaric acid was evaluated for solubility with the beta glucan and their intestinal absorption. In addition, improvement of productivity also achieved through the optimization of cultivation conditions and mutation of the original strain K-1. The solubility of p-coumaric acid and caffeic acid were increased 1.5 and 3 times higher, respectively, by addition of beta glucan, which was renatured by the alkaline treatment. Moreover, its productivity was so enhanced and a unique albino mutant was obtained. On the other hand, the urinary excretion of p-coumaric acid did not change significantly using renatured beta glucan as a dispersant after single oral administration to rats. This suggests that beta glucan did not inhibit the absorption of p-coumaric acid. Detaild effect through the above p-coumaric acid solution will be continued.