KINDAI UNIVERSITY


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TAKASHIMA Katsuki

Profile

FacultyDepartment of Pharmacy
PositionAssistant Professor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/2452-takashima-katsuki.html
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Last Updated :2020/09/01

Education and Career

Education

  •   2012 04  - 2016 03 , University of Toyama, Faculty of Engineering
  •   2016 04  - 2018 03 , University of Toyama, Graduate School of Science and Engineering for Education
  •   2018 04  - 2020 03 , University of Toyama, Graduate School of Innovative Life Science

Academic & Professional Experience

  •   2020 04 ,  - 現在, Faculty of Pharmacy, Kindai University

Research Activities

Published Papers

  • Probing the compatibility of an enzyme-linked immunosorbent assay toward the reprogramming of nonribosomal peptide synthetase adenylation domains, Fumihiro Ishikawa, Maya Nohara, Katsuki Takashima, Genzoh Tanabe, ChemBioChem, DOI: 10.1002/cbic.2000206, ChemBioChem, DOI: 10.1002/cbic.2000206, Jun. 2020 , Refereed
  • Formal Syntheses of (-)-Lepadiformines A, C, and (-)-Fasicularin., Katsuki Takashima, Daichi Hayakawa, Hiroaki Gouda, Naoki Toyooka, The Journal of organic chemistry, The Journal of organic chemistry, 84(9), 5222 - 5229, May 03 2019 , Refereed
    Summary:Marine tricyclic alkaloids lepadiformine and fasicularin, with a unique perhydropyrrolo[2,1- j]quinoline or perhydropyrido[2,1- j]quinoline framework, were synthesized starting from the B ring of the tricyclic system. This approach includes a highly stereocontrolled diallylation of a cyclic enaminoester and subsequent ring-closing metathesis to construct the A/B ring system, which was transformed into key lactams 32 and 33, and amino alcohol 37. Thus, we achieved formal syntheses of (-)-lepadiformines A, C, and (-)-fasicularin in a divergent manner.
  • FORMAL SYNTHESIS OF GEPHYROTOXIN 287C, Katsuki Takashima, Naoki Toyooka, HETEROCYCLES, HETEROCYCLES, 99(1), 649 - 660, Apr. 2019 , Refereed
    Summary:The enantioselective formal synthesis of (-)-gephyrotoxin 287C (1) has been achieved from octahydroquinolinone 8. The alpha, beta-unsaturated ester 16, whose enantiomer was a key intermediate for the total synthesis of (+)-1, was synthesized by highly stereoselective Michael-type conjugate addition reaction to 8 and subsequent transformations.

Conference Activities & Talks

  • Stereodivergent asymmetric synthesis of DHQ-type poison-frog alkaloids for SAR study to inhibitory effect of nicotinic acetylcholine receptors, Katsuki Takashima, Takuya Okada, Hinako Tanaka, Takeshi Sugouchi, Yoshiyuki Kubo, Kenichi Hosoya, Masashi Kawasaki, Naoki Toyooka, 27th ISHC,   2019 09 05
  • Total synthesis and their evaluation on poison-frog alkaloids ent-cis-195A and cis-211A, Takuya Okada, Katsuki Takashima, Jungoh Ishimura・Naizhen Wu・Hiroshi Tsuneki, Toshiyasu Sasaoka, Yuhei Yamazaki, Yoshiyuki Kubo, Ken-ichi Hosoya・Syed R. Hussaini・Linda, P. Dwoskin, Naoki Toyooka, IKCOC-14,   2018 11 15
  • Construction of aza-spirocyclic ring: synthetic studies on lepadiformines, Katsuki Takashima, hinako Tanaka, Naoki Toyooka, IKCOC-14,   2018 11 14

Misc

  • 毒ガエルアルカロイド195A,211Aの全合成研究, 岡田卓哉, 高島克輝, 石村潤郷, 児玉猛, 伊藤卓也, 森田洋行, 豊岡尚樹, 反応と合成の進歩シンポジウム講演要旨集, 42nd, 142,   2016 10 21 , http://jglobal.jst.go.jp/public/201702280928635026