KINDAI UNIVERSITY


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OTSUKA Airi

Profile

FacultyDepartment of Life Science
PositionAssistant Professor
DegreePh.D. in Medicine
Commentator Guidehttps://www.kindai.ac.jp/meikan/2307-otsuka-airi.html
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Last Updated :2020/06/01

Education and Career

Education

  •   2009 04  - 2013 03 , The University of Tokushima, Faculty of Medicine
  •   2013 04  - 2015 03 , The University of Tokushima, Graduate School of Nutrition and Bioscience
  •   2015 04  - 2019 03 , The University of Tokushima, Graduate School of Medical Sciences

Academic & Professional Experience

  •   2019 04 ,  - 現在, Faculty of Science and Engineering, Department of Life Science, Kindai University

Research Activities

Research Areas

  • Life sciences, Nutrition and health science

Published Papers

  • Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice., 514, 166 - 172, Jun. 2019 , Refereed
  • Sufficient intake of high-fat food attenuates stress-induced social avoidance behavior, Life Sciences, Life Sciences, 219, 219 - 230, Feb. 2019 , Refereed
  • Enhancement of fear learning in PPARα knockout mice, Chikahisa S, Chida D, Shiuchi T, Harada S, Shimizu N, Otsuka A, Tanioka D, Séi H, Behavioural Brain Research, Behavioural Brain Research, 359, 664 - 670, Feb. 2019 , Refereed
  • Modification of Energy Metabolism and Higher Brain Function by Feeding Rhythm, Otsuka Airi, Shiuchi Tetsuya, YAKUGAKU ZASSHI, YAKUGAKU ZASSHI, 138(10), 1297 - 1304, 2018 , Refereed
  • Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance, Chikahisa S, Harada S, Shimizu N, Shiuchi T, Otsuka A, Nishino S, Séi H, Scientific Reports, Scientific Reports, 7(1), Oct. 2017 , Refereed
  • Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice, Physiology & Behavior, Physiology & Behavior, 151, 264 - 271, Nov. 2015 , Refereed
  • Late feeding in the active period decreases slow-wave activity, Kanna Oura, Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei, LIFE SCIENCES, LIFE SCIENCES, 160, 18 - 26, Sep. 2016 , Refereed
    Summary:Aims: Sleep and feeding behaviors closely interact to maintain energy homeostasis. While it is known that sleep disorders can lead to various metabolic issues such as insulin resistance, the mechanism for this effect is poorly understood. We thus investigated whether different feeding rhythms during the active period affect sleep-wake regulation. Main methods: For 2 weeks, mice were randomly assigned to 1 of 3 feeding schedules as follows: free access to lab chow during the active period (ZT12-24, Ad-lib group), free access to lab chow during the first half of the active period (ZT12-18; Morning group), or free access to lab chow during the second half of the active period (ZT18-24, Evening group). Food intake, body weight, body temperature, locomotor activity, and sleep were evaluated. The hypothalamus and cerebral cortex were examined post-mortem. Key findings: No alterations in food intake or body weight were observed among the 3 groups. The Evening group showed lower slow-wave activity (SWA) than the other 2 groups, in addition to higher expression of orexin mRNA in the hypothalamus and higher concentrations of dopamine and its metabolites in the cerebral cortex. AMPK phosphorylation was increased in the hypothalamus of mice in the Evening group; however, AMPK inhibition had no effect on SWA. Significance: We concluded that late feeding reduces SWA in NREM sleep via a mechanism that involves orexin-mediated arousal in the hypothalamus and elevated monoamines in the cerebral cortex. These data have important implications for the relationship between sleep-wake disturbances and metabolic disorders. (C) 2016 Elsevier Inc. All rights reserved.