MATSUMOTO Ippei

Researcher Information

J-Global ID

• 200901066583855261

Research Areas

• Life sciences / Digestive surgery

Published Papers

• Efficacy and safety of neoadjuvant nab-paclitaxel plus gemcitabine therapy in patients with borderline resectable pancreatic cancer: A multicenter single-arm phase II study (NAC-GA trial).

  Ken-Ichi Okada; Kenjiro Kimura; Yo-Ichi Yamashita; Kazuto Shibuya; Ippei Matsumoto; Sohei Satoi; Kazuhiro Yoshida; Yasuhiro Kodera; Takahiro Akahori; Seiko Hirono; Hidetoshi Eguchi; Mitsuhiro Asakuma; Masaji Tani; Etsuro Hatano; Hisashi Ikoma; Go Ohira; Hiromitsu Hayashi; Ke Wan; Toshio Shimokawa; Manabu Kawai; Hiroki Yamaue

  Annals of gastroenterological surgery 7 (6) 997 - 1008 2023/11 

  BACKGROUND: Nab-paclitaxel plus gemcitabine is a standard treatment for metastatic/locally advanced pancreatic cancer. The effectiveness of neoadjuvant therapy with nab-paclitaxel plus gemcitabine (GnP-NAT) in patients with borderline resectable pancreatic cancer (BRPC) remains unclear. PATIENTS AND METHODS: This single-arm phase II trial included 61 patients with BRPC that were treated with two cycles of GnP-NAT, (nab-paclitaxel 125 mg/m2 and gemcitabine 1000 mg/m2), on days 1, 8, and 15 over a 4-week period, which comprised one cycle. The primary endpoint was overall survival time. In the absence of disease progression, patients underwent planned pancreatectomy. RESULTS: Median overall survival, the primary endpoint, was 25.2 months, and the median recurrence-free survival was 12.3 months. The overall rate of grade 3/4 events was 73.8%. One patient, who had a history of radiation therapy for past esophageal cancer, died from exacerbation via pneumonia. The overall resection rate was 73.8% (n = 45), and the R0 resection rate was 63.9% (n = 39). Overall, postoperative complications were found in 19 patients (42%) with 24 events, and nine patients (20%) with nine events ≥ grade IIIa, based on Dindo's classification. CONCLUSIONS: This protocol treatment is thought to be a feasible, safe, and promising treatment regimen, but we caution against its use in patients with a history of interstitial lung disease and/or prior pulmonary irradiation. The survival data from this study suggest the need for further investigations of GnP-NAT efficacy in patients with BRPC, as well as prospective evaluation of adverse events. CLINICAL TRIAL REGISTRATION: UMIN Clinical Trials Registry, UMIN000024154 and ClinicalTrials.gov, NCT02926183.
• High Incidence of Diabetes Mellitus After Distal Pancreatectomy and Its Predictors: A Long-term Follow-up Study

  Shuzo Imamura; Fumimaru Niwano; Naru Babaya; Yoshihisa Hiromine; Ippei Matsumoto; Keiko Kamei; Yuta Yoshida; Yasunori Taketomo; Sawa Yoshida; Yoshifumi Takeyama; Shinsuke Noso; Norikazu Maeda; Hiroshi Ikegami

  The Journal of Clinical Endocrinology & Metabolism The Endocrine Society 109 (3) 619 - 630 0021-972X 2023/10 

  Abstract Context Glucose tolerance worsens after distal pancreatectomy (DP); however, the long-term incidence and factors affecting interindividual variation in this worsening are unclear. Objective To investigate the changes in diabetes-related traits before and after DP and to clarify the incidence of diabetes and its predictors. Methods Among 493 registered patients, 117 underwent DP. Among these, 56 patients without diabetes before surgery were included in the study. Glucose and endocrine function were prospectively assessed using a 75-g oral glucose tolerance test preoperatively, 1 month after DP, and every 6 months thereafter for up to 36 months. Pancreatic volumetry was performed using multidetector row computed tomography before and after surgery. Results Insulin secretion decreased and blood glucose levels worsened after DP. Residual pancreatic volume was significantly associated with the reserve capacity of insulin secretion but not with blood glucose levels or the development of diabetes. Among 56 patients, 33 developed diabetes mellitus. The cumulative incidence of diabetes at 36 months after DP was 74.1%. Multivariate Cox regression analysis showed that impaired glucose tolerance as a preoperative factor as well as a decreased insulinogenic index and impaired glucose tolerance at 1 month postoperatively were identified as risk factors for diabetes following DP. Conclusion Impaired glucose tolerance and reduced early-phase insulin response to glucose are involved in the development of new-onset diabetes after DP; the latter is an additional factor in the development of diabetes and becomes apparent when pancreatic beta cell mass is reduced after DP.
• "Conversion surgery" for locally advanced pancreatic cancer: A position paper by the study group at the joint meeting of the International Association of Pancreatology (IAP) & Japan Pancreas Society (JPS) 2022.

  Atsushi Oba; Marco Del Chiaro; Tsutomu Fujii; Keiichi Okano; Thomas F Stoop; Y H Andrew Wu; Aya Maekawa; Yuta Yoshida; Daisuke Hashimoto; Toshitaka Sugawara; Yosuke Inoue; Minoru Tanabe; Masayuki Sho; Takashi Sasaki; Yu Takahashi; Ippei Matsumoto; Naoki Sasahira; Yuichi Nagakawa; Sohei Satoi; Richard D Schulick; Yoo-Seok Yoon; Jin He; Jin-Young Jang; Christopher L Wolfgang; Thilo Hackert; Marc G Besselink; Kyoichi Takaori; Yoshifumi Takeyama

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 23 (6) 712 - 720 2023/09 

  Locally advanced pancreatic cancer (LAPC), which progresses locally and surrounds major vessels, has historically been deemed unresectable. Surgery alone failed to provide curative resection and improve overall survival. With the advancements in treatment, reports have shown favorable results in LAPC after undergoing successful chemotherapy therapy or chemoradiation therapy followed by surgical resection, so-called "conversion surgery", at experienced high-volume centers. However, recognizing significant regional and institutional disparities in the management of LAPC, an international consensus meeting on conversion surgery for LAPC was held during the Joint Congress of the 26th Meeting of the International Association of Pancreatology (IAP) and the 53rd Annual Meeting of Japan Pancreas Society (JPS) in Kyoto in July 2022. During the meeting, presenters reported the current best multidisciplinary practices for LAPC, including preoperative modalities, best systemic treatment regimens and durations, procedures of conversion surgery with or without vascular resections, biomarkers, and genetic studies. It was unanimously agreed among the experts in this meeting that "cancer biology is surpassing locoregional anatomical resectability" in the era of effective multiagent treatment. The biology of pancreatic cancer has yet to be further elucidated, and we believe it is essential to improve the treatment outcomes of LAPC patients through continued efforts from each institution and more international collaboration. This article summarizes the agreement during the discussion amongst the experts in the meeting. We hope that this will serve as a foundation for future international collaboration and recommendations for future guidelines.
• Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.

  Daisuke Hashimoto; Sohei Satoi; Tsutomu Fujii; Masayuki Sho; Jin He; Thilo Hackert; Marco Del Chiaro; Jin-Young Jang; Aiste Gulla; Yoo-Seok Yoon; Yan-Shen Shan; Wenhui Lou; Roberto Valente; Junji Furuse; Atsushi Oba; Minako Nagai; Taichi Terai; Haruyoshi Tanaka; Ayano Sakai; Tomohisa Yamamoto; So Yamaki; Ippei Matsumoto; Yoshiaki Murakami; Kyoichi Takaori; Yoshifumi Takeyama

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 23 (6) 682 - 688 2023/09 

  Pancreatic ductal adenocarcinoma (PDAC) is a typical refractory malignancy, and many patients have distant organ metastases at diagnosis, such as liver metastasis and peritoneal dissemination. The standard treatment for unresectable PDAC with distant organ metastasis (UR-M) is chemotherapy, but the prognosis remained poor. However, with recent dramatic developments in chemotherapy, the prognosis has gradually improved, and some patients have experienced marked shrinkage or disappearance of their metastatic lesions. With this trend, attempts have been made to resect a small number of metastases (so-called oligometastases) in combination with the primary tumor or to resect the primary and metastatic tumor in patients with a favorable response to anti-cancer treatment after a certain period of time (so-called conversion surgery). An international consensus meeting on surgical treatment for UR-M PDAC was held during the Joint Congress of the 26th Meeting of the International Association of Pancreatology (IAP) and the 53rd Annual Meeting of the Japan Pancreas Society (JPS) in Kyoto in July 2022. The presenters showed their indications for and results of surgical treatment for UR-M PDAC and discussed their advantages and disadvantages with the experts. Although these reports were limited to a small number of patients, findings suggest that these surgical treatments for patients with UR-M PDAC who have had a significant response to chemotherapy may contribute to a prognosis of prolonged survival. We hope that this article summarizing the discussion and agreements at the meeting will serve as the basis for future trials and guidelines.
• Impact of antithrombotic therapy on postpancreatectomy hemorrhage in 7116 patients: A project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

  Kota Nakamura; Minako Nagai; Ippei Matsumoto; Sohei Satoi; Fuyuhiko Motoi; Manabu Kawai; Yasuo Hosouchi; Ryota Higuchi; Shugo Mizuno; Takao Ohtsuka; Keiichi Akahoshi; Kenichi Hakamada; Michiaki Unno; Hiroki Yamaue; Masafumi Nakamura; Itaru Endo; Masayuki Sho

  Journal of hepato-biliary-pancreatic sciences 2023/09 

  BACKGROUND: We previously reported an association between antithrombotic therapy and an increased risk of postpancreatectomy hemorrhage (PPH). To validate our findings, we conducted a large-scale multicenter retrospective study from 63 high-volume centers in Japan. METHODS: Between 2015 and 2018, 7116 patients who underwent pancreatectomy were enrolled. The antithrombotic group consisted of 920 patients (12.9%) who received preoperative antithrombotic agents including aspirin, clopidogrel, ticlopidine, prasugrel, warfarin, and direct oral anticoagulants. RESULTS: PPH occurred in 235 (3.3%) of the patients. The incidence of PPH and mortality were significantly higher in the antithrombotic group than in the control group (5.7 vs. 3.0% and 2.2 vs. 0.9%, respectively; both p < .001). In multivariate analysis, a history of antithrombotic use was an independent risk factor for grade C PPH (p = .036). In the antithrombotic group, PPH tended to be delayed in the patients with restarting antithrombotic therapy. Notably, the occurrence of delayed PPH after restarting antithrombotic therapy was observed only when antithrombotic therapy was restarted within 10 days after pancreatectomy. CONCLUSIONS: This multicenter study demonstrated that a history of antithrombotic use was a significant risk factor for PPH and mortality. In particular, the resumption of antithrombotic therapy in the early postoperative period should be done with caution.
• 急性膵炎の致命率改善への集学的治療 地域連携モデル構築による重症急性膵炎死亡率低減への取り組み

  竹中 完; 大本 俊介; 高島 耕太; 田中 秀和; 福永 朋洋; 吉田 晃浩; 山崎 友祐; 三長 孝輔; 鎌田 研; 亀井 敬子; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓 (一社)日本膵臓学会 38 (3) A169 - A169 0913-0071 2023/07
• 地域連携システムを用いた南大阪地区早期膵癌発見・診断プロジェクト

  吉田 晃浩; 竹中 完; 高島 耕太; 田中 秀和; 福永 朋洋; 山崎 友裕; 大本 俊介; 三長 孝輔; 鎌田 研; 亀井 敬子; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓 (一社)日本膵臓学会 38 (3) A370 - A370 0913-0071 2023/07
• 急性膵炎の致命率改善への集学的治療 地域連携モデル構築による重症急性膵炎死亡率低減への取り組み

  竹中 完; 大本 俊介; 高島 耕太; 田中 秀和; 福永 朋洋; 吉田 晃浩; 山崎 友祐; 三長 孝輔; 鎌田 研; 亀井 敬子; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓 (一社)日本膵臓学会 38 (3) A169 - A169 0913-0071 2023/07
• 地域連携システムを用いた南大阪地区早期膵癌発見・診断プロジェクト

  吉田 晃浩; 竹中 完; 高島 耕太; 田中 秀和; 福永 朋洋; 山崎 友裕; 大本 俊介; 三長 孝輔; 鎌田 研; 亀井 敬子; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓 (一社)日本膵臓学会 38 (3) A370 - A370 0913-0071 2023/07
• 肝転移を伴う膵癌に対するconversion surgeryの意義

  池浦 司; 橋本 大輔; 山本 智久; 藤井 努; 庄 雅之; 平野 聡; 上村 健一郎; 松本 逸平; 水間 正道; 井上 陽介; 中井 陽介; 室谷 健太; 里井 壯平; 竹山 宜典

  膵臓 (一社)日本膵臓学会 38 (3) A294 - A294 0913-0071 2023/07
• Transarterial chemoembolization for liver metastases of a pancreatic neuroendocrine neoplasm: a single-center experience.

  Yoshihide Nanno; Hirochika Toyama; Eisuke Ueshima; Keitaro Sofue; Ippei Matsumoto; Jun Ishida; Takeshi Urade; Kenji Fukushima; Hidetoshi Gon; Daisuke Tsugawa; Shohei Komatsu; Kaori Kuramitsu; Tadahiro Goto; Sadaki Asari; Hiroaki Yanagimoto; Masahiro Kido; Tetsuo Ajiki; Takumi Fukumoto

  Surgery today 2023/06 

  Transarterial chemoembolization (TACE) is performed for pancreatic neuroendocrine tumor (PanNEN) liver metastases; however, the safety and efficacy of TACE procedures, especially for patients who have undergone previous pancreatic surgery, have not been established. We reviewed 48 TACE procedures (1-6 procedures/patient) performed on 11 patients with PanNEN liver metastases, including 16 TACE procedures (4-6 procedures/patient) for 3 patients with a history of biliary-enteric anastomosis. The overall tumor objective response rate was 94%. The incidence of Clavien‒Dindo grade ≥ 2 complications was 1/16 (6%) and 1/32 (3%), and the median time to untreatable progression was 31 (14-41) and 27 (2-60) months among patients with and without a history of biliary-enteric anastomosis, respectively. Although validation is needed in future studies, our experiences have shown that TACE treatment is a viable treatment option for PanNEN liver metastases, even after biliary-enteric anastomosis with experienced teams and careful patient follow-up.
• 【急性膵炎診療ガイドライン改訂とPancreatitis Bundlesを読み解く】重症急性膵炎の担送基準と地域ネットワークの有用性

  竹中 完; 大本 俊介; 工藤 正俊; 松本 逸平; 竹山 宜典

  臨床消化器内科 (株)日本メディカルセンター 38 (8) 1041 - 1048 0911-601X 2023/06 

  ＜文献概要＞南大阪地域(面積880km2,25の市町村,人口230万人)における各施設の急性膵炎に対する診療体制の現状の把握,施設間連携の問題点の抽出,連携の強化により,急性膵炎治療の地域連携モデル構築を試みた.南大阪地域101施設へ,年間診療膵炎患者数,各施設での対応可能な膵炎の診療内容,Pancreatitis Bundlesの使用率,受け入れの実際,高次施設への搬送における問題点などについてアンケート調査を行い,「急性膵炎地域連携構築会議」と称して各病院の医師(外科/救命科/内科),医療連携事務が参加する会合を年に一度開催し,地域の現状を把握するとともに搬送に有用な膵炎MAPを作成し,膵炎治療成績向上を図った.Pancreatitis Bundlesの使用率は2016年の29%から2022年は86%にまで上昇した.また,南大阪地域における急性膵炎死亡率も2019年の全体で1.5%,重症膵炎に限定すると16.2%から,2021年は全体で1.1%,重症膵炎7.9%と改善が認められた.南大阪膵炎MAPと,地域連携構築会議を毎年開催することで,南大阪地区において急性膵炎患者の地域連携が構築されつつあり,急性膵炎患者に対する治療成績の向上と予後の改善が期待される.
• Gastrectomy reduces pancreatic secretory function via pancreatic atrophy.

  Shumpei Satoi; Yutaka Kimura; Rie Shimizu; Masataka Matsumoto; Kohei Kawaguchi; Yuta Yoshida; Takaaki Murase; Keiko Kamei; Ippei Matsumoto; Takuya Nakai; Yoshifumi Takeyama

  Surgery today 2023/04 

  PURPOSE: Although reports suggest that the pancreatic volume decreases after gastrectomy for gastric cancer, the relationship between the pancreatic volume and secretory function after gastrectomy remains unclear. In this study, we examined the relationship between the pancreatic volume and exocrine and endocrine functions after total gastrectomy. METHODS: The pancreatic volumes of 18 distal gastrectomy and 15 total gastrectomy patients were retrospectively measured using computed tomography volumetry up to 5 years postoperatively. Ten low anterior resection patients were selected as controls. In addition, the pancreatic volume and exocrine function evaluated by fecal elastase and the insulin secretory function evaluated by glucagon tolerance testing were prospectively examined before and one year after surgery in nine cases of total gastrectomy. RESULTS: After low anterior resection, the pancreatic volume did not change, but after distal and total gastrectomy, the pancreatic volume decreased continuously until the fifth year. After total gastrectomy, fecal elastase decreased significantly from 865.8 μg/g to 603.2 μg/g in the first year (p = 0.0316), and the insulin secretion capacity also decreased significantly from 3.83 ng/mL to 2.26 ng/mL (p = 0.0019). CONCLUSIONS: The pancreatic volume decreases continuously after gastrectomy for gastric cancer, and the pancreatic exocrine and endocrine functions decrease along with pancreatic atrophy after total gastrectomy.
• ASO Visual Abstract: Reappraisal of Malignant Risk Assessment for Small (≤20 mm) Non-functioning Pancreatic Neuroendocrine Tumors.

  Yoshihide Nanno; Hirochika Toyama; Ippei Matsumoto; Jun Uemura; Sadaki Asari; Tadahiro Goto; Dongha Lee; Tomomasa Murakami; Shohei Komatsu; Hiroaki Yanagimoto; Masahiro Kido; Tetsuo Ajiki; Keiichi Okano; Yoshifumi Takeyama; Takumi Fukumoto

  Annals of surgical oncology 30 (6) 3503 - 3504 2023/03
• Reappraisal of Malignant Risk Assessment for Small (≤20 mm) Non-functioning Pancreatic Neuroendocrine Tumors.

  Yoshihide Nanno; Hirochika Toyama; Ippei Matsumoto; Jun Uemura; Sadaki Asari; Tadahiro Goto; Dongha Lee; Tomomasa Murakami; Shohei Komatsu; Hiroaki Yanagimoto; Masahiro Kido; Tetsuo Ajiki; Keiichi Okano; Yoshifumi Takeyama; Takumi Fukumoto

  Annals of surgical oncology 30 (6) 3493 - 3500 2023/02 

  BACKGROUND: Optimal management of non-functioning pancreatic neuroendocrine tumors (PanNETs) ≤20 mm is controversial. The biological heterogeneity of these tumors poses challenges when deciding between resection and observation. METHODS: In this multicenter, retrospective cohort study, we analyzed all patients (n = 78) who underwent resection of non-functioning PanNETs ≤20 mm at three tertiary medical centers from 2004 to 2020 to assess the utility of preoperatively available radiological features and serological biomarkers of non-functioning PanNETs in choosing an optimal surgical indication. The radiological features included non-hyper-attenuation pattern on enhancement computed tomography (CT; hetero/hypo-attenuation) and main pancreatic duct (MPD) involvement, and serological biomarkers included elevation of serum elastase 1 and plasma chromogranin A (CgA) levels. RESULTS: Of all small non-functioning PanNETs, 5/78 (6%) had lymph node metastasis, 11/76 (14%) were WHO grade II, and 9/66 (14%) had microvascular invasion; 20/78 (26%) had at least one of these high-risk pathological factors. In the preoperative assessment, hetero/hypo-attenuation and MPD involvement were observed in 25/69 (36%) and 8/76 (11%), respectively. Elevated serum elastase 1 and plasma CgA levels were observed in 1/33 (3%) and 0/11 (0%) patients, respectively. On multivariate logistic regression analysis, hetero/hypo-attenuation (odds ratio [OR] 6.1, 95% confidence interval [CI] 1.7-22.2) and MPD involvement (OR 16.8, 95% CI 1.6-174.3) were significantly associated with the high-risk pathological factors. The combination of the two radiological worrisome features correctly predicted non-functioning PanNETs with high-risk pathological factors, with about 75% sensitivity, 79% specificity, and 78% accuracy. CONCLUSIONS: This combination of radiological worrisome features can accurately predict non-functioning PanNETs that may require resection.
• Gastrojejunostomy versus endoscopic duodenal stent placement for gastric outlet obstruction in patients with unresectable pancreatic cancer: a propensity score-matched analysis.

  Takashi Tamura; Takenaka Mamoru; Taichi Terai; Takeshi Ogura; Masaji Tani; Toshio Shimokawa; Yuji Kitahata; Ippei Matsumoto; Akira Mitoro; Mitsuhiro Asakuma; Osamu Inatomi; Shunsuke Omoto; Masayuki Sho; Saori Ueno; Hiromitsu Maehira; Masayuki Kitano

  Surgical endoscopy 37 (3) 1890 - 1900 2022/10 

  BACKGROUND: Treatments for patients with gastric outlet obstruction (GOO) due to unresectable pancreatic cancers (URPC) include gastrojejunostomy (GJJ) and endoscopic duodenal stent placement (EDSP). This study compared the efficacy and safety of GJJ and EDSP in patients with GOO due to URPC. METHODS: This study retrospectively evaluated consecutive patients with GOO due to URPC who underwent GJJ or EDSP between April 2016 and March 2020. The efficacy and safety of GJJ and EDSP were compared with propensity score analysis. Subgroup analyses of overall survival (OS) were compared after propensity matching. RESULTS: Data were obtained from 54 patients who underwent GJJ and from 73 who underwent EDSP at five tertiary care hospitals. After propensity matching, OS was significantly longer in patients who underwent GJJ than EDSP (110 vs. 63 days, respectively; p = 0.019). Evaluation of long-term adverse events showed that the frequency of cholangitis and obstructive jaundice was significantly lower in the matched GJJ than in the matched EDSP group (p = 0.012). Subgroup analyses showed that OS in patients with good performance status (PS; p = 0.041), biliary obstruction (p = 0.007), and duodenal obstruction near the papilla (p = 0.027), and those receiving chemotherapy (p = 0.010), was significantly longer in the matched GJJ group than in matched EDSP group. CONCLUSION: GJJ provides longer OS than EDSP for patients with GOO caused by URPC, especially for patients with good PS, biliary obstruction, and duodenal obstruction near the papilla, and those receiving chemotherapy.
• Three-year observation of glucose metabolism after pancreaticoduodenectomy: A single-center prospective study in Japan

  Fumimaru Niwano; Naru Babaya; Yoshihisa Hiromine; Ippei Matsumoto; Keiko Kamei; Yasunori Taketomo; Sawa Yoshida; Yoshifumi Takeyama; Shinsuke Noso; Hiroshi Ikegami

  The Journal of Clinical Endocrinology & Metabolism The Endocrine Society 107 (12) 3362 - 3369 0021-972X 2022/09 

  Abstract Context The glucose tolerance of patients changes considerably from before to after pancreaticoduodenectomy wherein approximately half of the pancreas is resected. Purpose The aim of this prospective study was to investigate the incidence of and risk factors for diabetes after pancreaticoduodenectomy. Methods This study is a part of an ongoing prospective study, the Kindai Prospective Study on Metabolism and Endocrinology after Pancreatectomy (KIP-MEP) study. Of the 457 patients enrolled to date, 96 patients without diabetes who underwent pancreaticoduodenectomy were investigated in this study. Preoperatively, 1-month post-pancreaticoduodenectomy, and every 6 months thereafter, the glucose metabolism and endocrine function were evaluated using the 75-g oral glucose tolerance test. Various other metabolic, endocrine, and exocrine indices were also examined over a period of up to 36 months. Results Of the 96 patients analyzed in this study, 33 were newly diagnosed with diabetes. The cumulative diabetes incidence at 36 months following pancreaticoduodenectomy was 53.8%. The preoperative insulinogenic index and ΔC-peptide in the glucagon stimulation test were significantly lower in the progressors than in the non-progressors to diabetes. Multivariate Cox regression analysis demonstrated that the insulinogenic index was the only significant risk factor for new-onset diabetes. Conclusions The majority of patients developed new-onset diabetes after pancreaticoduodenectomy, and a low value of the insulinogenic index was suggested to be a risk factor for diabetes. Preoperative assessment for the prediction of the onset of diabetes serves as useful information for patients and is important for postoperative glycemic control and diabetes management in patients who require pancreaticoduodenectomy.
• Risk factors associated with hypoglycemic events after total pancreatectomy: A nationwide multicenter prospective study in Japan.

  Hironobu Suto; Keiko Kamei; Hiroyuki Kato; Takeyuki Misawa; Michiaki Unno; Hiroyuki Nitta; Sohei Satoi; Yasunari Kawabata; Masayuki Ohtsuka; Toshiki Rikiyama; Takeshi Sudo; Ippei Matsumoto; Tomohiro Hirao; Keiichi Okano; Yasuyuki Suzuki; Naohiro Sata; Shuji Isaji; Masanori Sugiyama; Yoshifumi Takeyama

  Surgery 172 (3) 962 - 967 2022/09 

  BACKGROUND: The number of total pancreatectomy cases have increased worldwide, expanding the need for new insulin products and high-titer pancrelipases. However, the current data that is focused on hypoglycemic events after a total pancreatectomy from large nationwide series are still lacking. This study is aimed to assess the risk factors associated with hypoglycemic events after a total pancreatectomy. METHODS: Data were prospectively collected from 216 consecutive patients who underwent total pancreatectomies between August 2015 and December 2017 from 68 Japanese centers. Of the 216 patients, 166 with a follow-up period of 1 year were analyzed. The risk factors for hypoglycemic events at 6 and 12 months (postoperative months 6 and 12) were investigated based on the results of a nationwide multicenter prospective study. RESULTS: Of the 166 patients, 57 (34%) and 70 (42%) experienced moderate or severe hypoglycemic events or hypoglycemia unawareness on a monthly basis at postoperative months 6 and 12, respectively. Multivariate analysis revealed that body weight loss after surgery ≥0.3 kg and total cholesterol level ≤136 mg/dL at postoperative month 6, and glycated hemoglobin level ≤8.9% and rapid-acting insulin use at postoperative month 12 were independent risk factors for hypoglycemic events after a total pancreatectomy. There were different independent risk factors depending on the postoperative period. CONCLUSION: Patients with body weight loss after surgery, low total cholesterol level, strict glycemic control, and using rapid-acting insulin should be aware of the occurrence of hypoglycemic events after their total pancreatectomy. In order to prevent hypoglycemic events after a total pancreatectomy, we need to consider optimal nutritional and glycemic control according to the postoperative period.
• Utility of contrast-enhanced harmonic EUS for diagnosis of portal vein invasion by pancreatic cancer.

  Atsushi Nakai; Ken Kamata; Tomoko Hyodo; Takaaki Chikugo; Akane Hara; Yasuo Otsuka; Hidekazu Tanaka; Tomoe Yoshikawa; Rei Ishikawa; Ayana Okamoto; Tomohiro Yamazaki; Shunsuke Omoto; Kosuke Minaga; Kentaro Yamao; Mamoru Takenaka; Yasutaka Chiba; Tomohiro Watanabe; Ippei Matsumoto; Yoshifumi Takeyama; Masatoshi Kudo

  Endoscopic ultrasound 11 (5) 401 - 406 2022/07 

  Background: The value of contrast-enhanced harmonic EUS (CH-EUS) for diagnosis of portal vein invasion in patients with pancreatic cancer was evaluated. Patients and Methods: This single-center, retrospective study included consecutive patients with pancreatic cancer who underwent both surgical resection after preoperative EUS, CH-EUS, and contrast-enhanced computed tomography (CE-CT) examinations between April 2015 and August 2017. CH-EUS evaluation was performed during the late phase. Portal vein invasion on EUS and CH-EUS was defined as no continuity in the line of the vessel wall. Definition of portal vein invasion on CE-CT was based on the Loyer's criteria. The accuracy of three modalities for diagnosis of invasion into the portal vein was compared using the McNemar's test. Results: Eighty-eight patients (mean age: 71.0 years, ratio of male to female: 48:40) were eligible. Postoperative pathological results were as follows: seven cases of portal vein invasion; 81 cases without. Diagnostic accuracy of EUS, CH-EUS, and CE-CT for diagnosing invasion into the portal vein was 72.7%, 93.2%, and 81.8%, respectively. The differences between CH-EUS and CE-CT (P = 0.0094) and CH-EUS and EUS (P = 0.0022) were significant. EUS and CE-CT were comparable. Conclusion: CH-EUS is useful for diagnosis of portal vein invasion by pancreatic cancer.
• Comparison of infectious complications after spleen preservation versus splenectomy during laparoscopic distal pancreatectomy for benign or low-grade malignant pancreatic tumors: A multicenter, propensity score-matched analysis.

  Woohyung Lee; Dae Wook Hwang; Ho-Seong Han; In Woong Han; Jin Seok Heo; Michiaki Unno; Masaharu Ishida; Hiroshi Tajima; Nobuyuki Nishizawa; Kohei Nakata; Yasuji Seyama; Yoshiya Isikawa; Ho Kyoung Hwang; Jin-Young Jang; Taeho Hong; Joon Seong Park; Hee Joon Kim; Chi-Young Jeong; Ippei Matsumoto; Hiroki Yamaue; Manabu Kawai; Masayuki Ohtsuka; Shugo Mizuno; Mitsuhiro Asakuma; Yuji Soejima; Teijiro Hirashita; Masayuki Sho; Yutaka Takeda; Jeong-Ik Park; Yong Hoon Kim; Hwa Jung Kim; Hiroki Yamaue; Masakazu Yamamoto; Itaru Endo; Masafumi Nakamura; Yoo-Seok Yoon

  Journal of hepato-biliary-pancreatic sciences 30 (2) 252 - 262 2022/06 

  BACKGROUND: Previous studies have reported contrasting results regarding the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications. METHODS: A total of 3787 patients who underwent LDP for benign or low-grade malignant pancreatic disease in 92 centers across Korea and Japan were included in this retrospective study. Postoperative infectious complications and other complications were compared between LDP with splenectomy (LDPS) and LDP with spleen preservation (LSPDP) by propensity score matching (PSM) analysis. RESULTS: After PSM, the LSPDP group had a lower rate of overall infectious complications (P = .079) and a significantly lower rate of intra-abdominal abscess (P = .014) compared with the LDPS group. Within the LSPDP group, the vessel preservation subgroup had a significantly higher rate of infectious complications (P = .002) compared with the vessel resection subgroup. Low-volume centers had a higher rate of intra-abdominal abscess than high-volume centers in the LSPDP group (P = .001) and the splenic vessel preservation subgroup (P = .003). CONCLUSIONS: Spleen preservation in LDP for benign or borderline malignant pancreatic diseases was advantageous in lowering the risk of infectious complications, specifically intra-abdominal abscess. However, the risk of intra-abdominal abscess may differ according to the level of surgeon's experience.
• Longitudinal Pancreaticojejunostomy for Pancreaticodigestive Tract Anastomotic Stricture After Pancreaticoduodenectomy.

  Ippei Matsumoto; Keiko Kamei; Kohei Kawaguchi; Yuta Yoshida; Masataka Matsumoto; Dongha Lee; Takaaki Murase; Shumpei Satoi; Atsushi Takebe; Yoshifumi Takeyama

  Annals of gastroenterological surgery 6 (3) 412 - 419 2022/05 

  Aim: Pancreaticodigestive tract anastomotic stricture is a long-term complication of pancreticoduodenectomy (PD). However, optimal treatment has not yet been defined. We conducted longitudinal pancreaticojejunostomy (LPJ) in symptomatic patients with anastomotic stricture after PD. This study aimed to evaluate the efficacy of this procedure. Methods: Pancreticoduodenectomy was performed in 605 patients at our institution between January 2005 and April 2020. Of these, 15 patients (2.5%) developed symptomatic pancreaticodigestive tract anastomotic stricture after PD. Three patients were referred to our institution owing to recurrent pancreatitis with anastomotic stricture after PD. LPJ was indicated for these 18 patients, and they were enrolled in this study. Results: The median time from the initial operation to LPJ was 2.0 y. Preoperative clinical presentations included obstructive pancreatitis in 10 patients, a rapid deterioration of glucose tolerance in nine, and severe steatorrhea in two. Surgical morbidity ≥grade III defined by the Clavien-Dindo classification was not observed. After LPJ, preoperative symptoms improved in 16 patients (89%) during a median follow-up of 39 mo. Nine of the 10 patients with obstructive pancreatitis achieved complete pain relief. All nine patients with a rapid deterioration of glucose tolerance showed improved endocrine function. Daily insulin requirement was significantly decreased after LPJ (11.6 ± 3.3 vs 3.4 ± 4.3 units, P = .0239). Four of the seven patients who required insulin injections were free of insulin after LPJ. Conclusion: LPJ is a safe and effective surgical procedure for symptomatic patients with stricture of the pancreaticodigestive tract anastomosis after PD.
• Clinicopathological variables and risk factors for lung recurrence after resection of pancreatic ductal adenocarcinoma.

  Yu Asakura; Hirochika Toyama; Jun Ishida; Sadaki Asari; Sachio Terai; Sachiyo Shirakawa; Hironori Yamashita; Takashi Shimizu; Yuta Ogura; Ippei Matsumoto; Hidetoshi Gon; Daisuke Tsugawa; Shohei Komatsu; Kaori Kuramitsu; Hiroaki Yanagimoto; Masahiro Kido; Tetsuo Ajiki; Takumi Fukumoto

  Asian journal of surgery 46 (1) 207 - 212 2022/03 

  BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence rate even after curative resection. Lung recurrence may have better outcomes than other recurrences. However, its detailed clinicopathological features are unclear. We investigated the clinicopathological features and risk factors for lung recurrence after pancreatectomy for PDAC. METHODS: The study included 161 patients with potentially and borderline resectable PDAC who had undergone R0 or R1 pancreatectomy between January 2008 and December 2016. We retrospectively examined the prognosis and predictors for lung recurrence after curative resection. RESULTS: Seventeen patients (10.6%) had isolated lung recurrence. The median overall and recurrence-free survivals were 38.0 and 16.1 months, respectively. In multivariate analysis, para-aortic lymph node (PALN) metastasis (p = 0.006) and female sex (p = 0.027) were independent factors for lung recurrence. CONCLUSION: Lung recurrence had a better prognosis than other recurrences. PALN metastasis and female sex are independent risk factors for lung recurrence after curative resection for PDAC.
• Incidence and risk factors of nonalcoholic fatty liver disease after total pancreatectomy: A first multicenter prospective study in Japan.

  Hiroyuki Kato; Keiko Kamei; Hironobu Suto; Takeyuki Misawa; Michiaki Unno; Hiroyuki Nitta; Sohei Satoi; Yasunari Kawabata; Masayuki Ohtsuka; Toshiki Rikiyama; Takeshi Sudo; Ippei Matsumoto; Keiichi Okano; Yasuyuki Suzuki; Naohiro Sata; Shuji Isaji; Masanori Sugiyama; Yoshifumi Takeyama

  Journal of hepato-biliary-pancreatic sciences 29 (4) 428 - 438 2021/12 

  BACKGROUND/PURPOSE: In the present study we aimed to prospectively assess the current prevalence and risk factors of nonalcoholic fatty liver disease (NAFLD) after total pancreatectomy (TP). METHODS: Between August 2015 and December 2017, we prospectively collected data from 68 Japanese centers on 148 consecutive patients who underwent TP whose computed tomography (CT) attenuation values were evaluated for 12 months. We defined post-TP NAFLD as a liver parenchyma CT value of less than 40 Hounsfield units (HU). Data on perioperative variables were retrieved from all patients and evaluated using univariate and multivariate analyses to identify the perioperative risk factors of NAFLD. RESULTS: In this prospective cohort study, supplementation of pancreatic exocrine enzymes was provided to all 148 patients, and 97% of them were treated with high-titer pancrelipase (median dosage: 1800 mg) postoperatively. Indeed, 29 patients (19.6%) developed NAFLD within a year after TP. Multivariate analysis revealed that female sex (P = .002), higher body mass index (BMI) (P = .001), and postoperative diarrhea (P = .038) were independent risk factors for post-TP NAFLD. However, post-TP NAFLD ameliorated in 11 patients (37.9%) at 12 months after surgery. CONCLUSIONS: Among patients with risk factors such as female sex, higher BMI, and postoperative diarrhea, attention should be paid to the occurrence of NAFLD after TP.
• Glucose Tolerance after Pancreatectomy: A Prospective Observational Follow-Up Study of Pancreaticoduodenectomy and Distal Pancreatectomy.

  Jun Ishida; Hirochika Toyama; Ippei Matsumoto; Sachiyo Shirakawa; Sachio Terai; Hironori Yamashita; Hiroaki Yanagimoto; Sadaki Asari; Masahiro Kido; Takumi Fukumoto

  Journal of the American College of Surgeons 233 (6) 753 - 762 2021/12 

  BACKGROUND: Effects of pancreatectomy on glucose tolerance have not been clarified, and evidence regarding the difference in postoperative glucose tolerance between pancreaticoduodenectomy (PD) and distal pancreatectomy (DP) is lacking. STUDY DESIGN: This prospective, single-center observational study analyzed 40 patients undergoing PD and 29 patients undergoing DP (Clinical trial registry number UMIN000008122). Glucose tolerance, including insulin secretion (Δ C-peptide immunoreactivity, ΔCPR) and insulin resistance (homeostasis model assessment of insulin resistance, HOMA-IR) were assessed before and 1 month after pancreatectomy using the oral glucose tolerance test (OGTT) and glucagon stimulation test. We assessed long-term hemoglobin A1c (HbA1c) levels in patients, with a follow-up time of 3 years. RESULTS: Percentages of patients diagnosed with abnormal OGTT decreased after PD (from 12 [30%] to 7 [17.5%] of 40 patients, p = 0.096); however, they increased after DP (from 4 [13.8%] to 8 [27.6%] of 29 patients, p = 0.103), although the changes were not statistically significant. ΔCPR decreased after both PD (from 3.2 to 1.0 ng/mL, p < 0.001) and DP (from 3.3 to 1.8 ng/mL, p < 0.001). HOMA-IR decreased after PD (from 1.10 to 0.68, p < 0.001), but did not change after DP (1.10 and 1.07, p = 0.42). Median HbA1c level was higher after DP than after PD for up to 3 years, but the differences were not statistically significant. CONCLUSIONS: In comparisons of pre- and 1 month post-pancreatectomy data, glucose tolerance showed improvement after PD, whereas it worsened after DP. Insulin secretion decreased after both PD and DP. Insulin resistance improved after PD, but did not change after DP. Further studies are warranted to clarify mechanisms of improved insulin resistance after PD.
• 動脈結紮術を施行した未破裂第一空腸動脈瘤の1例

  山田 淳史; 松本 逸平; 松本 正孝; 吉田 雄太; 登 千穂子; 川口 晃平; 李 東河; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本臨床外科学会雑誌 日本臨床外科学会 82 (増刊) S863 - S863 1345-2843 2021/10
• 弓状靱帯狭窄症による前上膵十二指腸動脈瘤コイル塞栓後に生じた十二指腸狭窄に対する1手術例

  松本 正孝; 松本 逸平; 吉田 雄太; 山田 淳史; 登 千穂子; 川口 晃平; 李 東河; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本臨床外科学会雑誌 日本臨床外科学会 82 (増刊) S1208 - S1208 1345-2843 2021/10
• ISOlation Procedure vs. conventional procedure during Distal Pancreatectomy (ISOP-DP trial): study protocol for a randomized controlled trial.

  Ken-Ichi Okada; Manabu Kawai; Seiko Hirono; Masayuki Sho; Masaji Tani; Ippei Matsumoto; Suguru Yamada; Ryosuke Amano; Hirochika Toyama; Yo-Ichi Yamashita; Takeshi Gocho; Kazuto Shibuya; Minako Nagai; Hiromitsu Maehira; Keiko Kamei; Go Ohira; Yoshihiro Shirai; Hideki Takami; Nana Kimura; Takumi Fukumoto; Hideo Baba; Yasuhiro Kodera; Akimasa Nakao; Toshio Shimokawa; Masahiro Katsuda; Hiroki Yamaue

  Trials 22 (1) 633 - 633 2021/09 

  BACKGROUND: Radical antegrade modular pancreatosplenectomy (RAMPS) is an isolation procedure in pancreatosplenectomy for pancreatic body/tail cancer. Connective tissues around the bifurcation of the celiac axis are dissected, followed by median-to-left retroperitoneal dissection. This procedure has the potential to isolate blood and lymphatic flow to the area of the pancreatic body/tail and the spleen to be excised. This is achieved by division of the inflow artery, transection of the pancreas, and then division of the outflow vein in the early phases of surgery. In cases of pancreatic ductal adenocarcinoma (PDAC), the procedure has been shown to decrease intraoperative blood loss and increase R0 resection rate by complete clearance of the lymph nodes. This trial investigates whether the isolation procedure can prolong the survival of patients with pancreatic ductal adenocarcinoma who undergo distal pancreatosplenectomy (DPS) compared with those that undergo the conventional approach. METHODS/DESIGN: Patients with PDAC scheduled to undergo DPS are randomized before surgery to undergo either a conventional procedure (arm A) or to undergo the isolation procedure (arm B). In arm A, the pancreatic body, tail, and spleen are mobilized, followed by removal of the regional lymph nodes. The splenic vein is transected at the end of the procedure. The timing of division of the splenic artery (SA) is not restricted. In arm B, regional lymph nodes are dissected, then we transect the root of the SA, the pancreas, then the splenic vein. At the end of the procedure, the pancreatic body/tail and spleen are mobilized and removed. In total, 100 patients from multiple Japanese high-volume centers will be randomized. The primary endpoint is 2-year recurrence-free survival by intention-to-treat analysis. Secondary endpoints include intraoperative blood loss, R0 resection rate, and overall survival. DISCUSSION: If this trial shows that the isolation procedures can improve survival with a similar R0 rate and with a similar number of lymph node dissections to the conventional procedure, the isolation procedure is expected to become a standard procedure during DPS for PDAC. Conversely, if there were no significant differences in endpoints between the groups, it would demonstrate justification of either procedure from surgical and oncological points of view. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000041381 . Registered on 10 August 2020. ClinicalTrials.gov NCT04600063 . Registered on 22 October 2020.
• Utility of contrast-enhanced harmonic endoscopic ultrasonography for T-staging of patients with extrahepatic bile duct cancer

  Yasuo Otsuka; Ken Kamata; Tomoko Hyodo; Takaaki Chikugo; Akane Hara; Hidekazu Tanaka; Tomoe Yoshikawa; Rei Ishikawa; Ayana Okamoto; Tomohiro Yamazaki; Atsushi Nakai; Shunsuke Omoto; Kosuke Minaga; Kentaro Yamao; Mamoru Takenaka; Yasutaka Chiba; Tomohiro Watanabe; Takuya Nakai; Ippei Matsumoto; Yoshifumi Takeyama; Masatoshi Kudo

  Surgical Endoscopy Springer Science and Business Media LLC 36 (5) 3254 - 3260 0930-2794 2021/08
• 慢性膵炎による難治性疼痛に対する内科的インターベンション治療と外科治療の比較解析

  松本 逸平; 三長 孝輔; 村瀬 貴昭; 宮田 剛; 川口 晃平; 亀井 敬子; 水野 修吾; 糸井 隆夫; 大原 弘隆; 正宗 淳; 阪上 順一; 佐田 尚宏; 竹中 完; 北野 雅之; 乾 和郎; 竹山 宜典

  膵臓 (一社)日本膵臓学会 36 (3) A123 - A123 0913-0071 2021/08
• 局所進行切除不能膵癌に対するConversion surgeryのタイミング〜内科と外科の連携〜 当院における局所進行切除不能膵癌に対するconversion surgeryの短期・長期成績の検討

  吉田 雄太; 松本 逸平; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 鎌田 研; 山雄 健太郎; 竹中 完; 竹山 宜典

  膵臓 (一社)日本膵臓学会 36 (3) A146 - A146 0913-0071 2021/08
• Efficacy of the slow firing method using a reinforced triple-row stapler for preventing postoperative pancreatic fistula during laparoscopic distal pancreatectomy.

  Ippei Matsumoto; Keiko Kamei; Shumpei Satoi; Takaaki Murase; Masataka Matsumoto; Kohei Kawaguchi; Yuta Yoshida; Lee Dongha; Atsushi Takebe; Takuya Nakai; Yoshifumi Takeyama

  Surgery today 52 (2) 260 - 267 2021/07 

  PURPOSE: Postoperative pancreatic fistula (POPF) remains the most clinically relevant complication of laparoscopic distal pancreatectomy (LDP). The present study evaluated the efficacy of the "slow firing method" using a reinforced triple-row stapler (Covidien, Tokyo, Japan) during LDP. METHODS: This retrospective single-center study included 73 consecutive patients who underwent LDP using the slow firing method. A black cartridge was used in all patients. The primary endpoint was the rate of clinically relevant POPF (CR-POPF) after LDP. Secondary endpoints included perioperative outcomes and factors associated with CR-POPF as well as the correlation between the transection time and thickness of the pancreas. RESULTS: Four patients (5.5%) developed CR-POPF (grade B). Overall morbidity rates, defined as grade ≥ II and ≥ III according to the Clavien-Dindo classification, were 21 and 11%, respectively. The median postoperative hospital stay was 10 days. Preoperative diabetes (13.6 vs. 0.2%, P = 0.044) and thickness of the pancreas ≥ 15 mm (13.8% vs. 0%, P = 0.006) were identified as independent risk factors for CR-POPF. The median transection time was 16 (8-29) min. CONCLUSION: The slow firing method using a reinforced triple-row stapler for pancreatic transection is simple, safe, and effective for preventing CR-POPF after LDP.
• Diabetic control and nutritional status up to 1 year after total pancreatectomy: a nationwide multicentre prospective study.

  H Suto; K Kamei; H Kato; T Misawa; M Unno; H Nitta; S Satoi; Y Kawabata; M Ohtsuka; T Rikiyama; T Sudo; I Matsumoto; T Hirao; K Okano; Y Suzuki; N Sata; S Isaji; M Sugiyama; Y Takeyama

  The British journal of surgery 108 (7) e237-e238  2021/07
• Utility of contrast-enhanced harmonic endoscopic ultrasonography for predicting the prognosis of pancreatic neuroendocrine neoplasms.

  Rei Ishikawa; Ken Kamata; Akane Hara; Hidekazu Tanaka; Ayana Okamoto; Tomohiro Yamazaki; Atsushi Nakai; Shunsuke Omoto; Kosuke Minaga; Kentaro Yamao; Mamoru Takenaka; Yasunori Minami; Tomohiro Watanabe; Yasutaka Chiba; Takaaki Chikugo; Ippei Matsumoto; Yoshifumfi Takeyama; Yuko Matsukubo; Tomoko Hyodo; Masatoshi Kudo

  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 33 (5) 829 - 839 2021/07 

  BACKGROUND AND AIMS: Pancreatic neuroendocrine neoplasms (PanNENs), including Grade 1 (G1) or G2 tumors, can have a poor prognosis. This study investigated the value of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for predicting the prognosis of PanNENs. METHODS: This single-center, retrospective study included 47 consecutive patients who underwent CH-EUS and were diagnosed with PanNEN by surgical resection or EUS-guided fine needle aspiration between December 2011 and February 2016. Patients were divided into aggressive and non-aggressive groups according to the degree of clinical malignancy. CH-EUS was assessed regarding its capacity for diagnosing aggressive PanNEN, the correspondence between contrast patterns and pathological features, and its ability to predict the prognosis of PanNEN. RESULTS: There were 19 cases of aggressive PanNEN and 28 cases of non-aggressive PanNEN. The aggressive group included three G1, four G2, three G3 tumors, three mixed neuroendocrine non-neuroendocrine neoplasms, and six neuroendocrine carcinomas. CH-EUS was superior to contrast-enhanced computed tomography for the diagnosis of aggressive PanNEN (P < 0.001): hypo-enhancement on CH-EUS was an indicator of aggressive PanNEN, with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 94.7%, 100%, 100%, 96.6%, and 97.9%, respectively. Among G1/G2 PanNENs, cases with hypo-enhancement on CH-EUS had a poorer prognosis than those with hyper/iso-enhancement (P = 0.0009). Assessment of 36 resected specimens showed that hypo-enhancement on CH-EUS was associated with smaller and fewer vessels and greater degree of fibrosis. CONCLUSION: Contrast-enhanced harmonic endoscopic ultrasonography may be useful for predicting the prognosis of PanNENs.
• 膵切除術前後における内分泌・代謝動態の前向き観察研究(KIP-MEP study) 膵頭十二指腸切除と膵体尾部切除の相違

  庭野 史丸; 馬場谷 成; 廣峰 義久; 松本 逸平; 亀井 敬子; 武友 保憲; 川畑 由美子; 竹山 宜典; 能宗 伸輔; 池上 博司

  糖尿病 (一社)日本糖尿病学会 64 (Suppl.1) I - 4 0021-437X 2021/05
• Safety of Combined Division vs Separate Division of the Splenic Vein in Patients Undergoing Distal Pancreatectomy: A Noninferiority Randomized Clinical Trial.

  Suguru Yamada; Tsutomu Fujii; Fuminori Sonohara; Manabu Kawai; Kazuto Shibuya; Ippei Matsumoto; Kengo Fukuzawa; Hideo Baba; Takeshi Aoki; Michiaki Unno; Sohei Satoi; Yoji Kishi; Etsuro Hatano; Kenichiro Uemura; Akihiko Horiguchi; Masayuki Sho; Yutaka Takeda; Toshio Shimokawa; Yasuhiro Kodera; Hiroki Yamaue

  JAMA surgery 156 (5) 418 - 428 2021/05 

  Importance: In distal pancreatectomy (DP), the splenic vein is isolated from the pancreatic parenchyma prior to being ligated and divided to prevent intra-abdominal hemorrhage from the splenic vein stump with pancreatic fistula (PF). Conversely, dissecting the splenic vein with the pancreatic parenchyma is easy and time-saving. Objective: To establish the safety of combined division of the splenic vein compared with separate division of the splenic vein. Design, Setting, and Participants: This study was designed as a multicenter prospective randomized phase 3 trial. All results were analyzed using the modified intent-to-treat set. Patients undergoing DP for pancreatic body and tail tumors were eligible for inclusion. Patients were randomly assigned between August 10, 2016, and July 30, 2019. Interventions: Patients were centrally randomized (1:1) to either separate division of the splenic vein or combined division of the splenic vein. Main Outcomes and Measures: The primary end point was the incidence of grade B/C PF, and the incidence of intra-abdominal hemorrhage was included as one of the secondary end points. Results: A total of 318 patients were randomly assigned, and 2 patients were excluded as ineligible. Of the 316 remaining patients, 150 (50.3%) were male. The modified intent-to-treat population constituted 159 patients (50.3%) in the separate division group and 157 patients (49.7%) in the combined division group. In the modified intent-to-treat set, the proportion of grade B/C PF in the separate division group was 27.1% (42 of 155) vs 28.6% (44 of 154) in the combined division group (adjusted odds ratio, 1.108; 95% CI, 0.847-1.225; P = .047), demonstrating noninferiority of the combined division of the splenic vein against separate division. The incidence of postoperative intra-abdominal hemorrhage in the 2 groups was identical at 1.3%. Conclusions and Relevance: This study demonstrated noninferiority of the combined division of the splenic vein compared with separate division of the splenic vein regarding safety. Thus, isolating the splenic vein from the pancreatic parenchyma is deemed unnecessary. Trial Registration: ClinicalTrials.gov Identifier: NCT02871804.
• Glucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy.

  Fumimaru Niwano; Naru Babaya; Yoshihisa Hiromine; Ippei Matsumoto; Keiko Kamei; Shinsuke Noso; Yasunori Taketomo; Yoshifumi Takeyama; Yumiko Kawabata; Hiroshi Ikegami

  The Journal of clinical endocrinology and metabolism 106 (5) e2203-e2214  2021/04 

  CONTEXT: The rate of glucose metabolism changes drastically after partial pancreatectomy. OBJECTIVE: This work aims to analyze changes in patients' glucose metabolism and endocrine and exocrine function before and after partial pancreatectomy relative to different resection types (Kindai Prospective Study on Metabolism and Endocrinology after Pancreatectomy: KIP-MEP study). METHODS: A series of 278 consecutive patients with scheduled pancreatectomy were enrolled into our prospective study. Of them, 109 individuals without diabetes, who underwent partial pancreatectomy, were investigated. Data were compared between patients with pancreaticoduodenectomy (PD, n = 73) and those with distal pancreatectomy (DP, n = 36). RESULTS: Blood glucose levels during the 75-g oral glucose tolerance test (75gOGTT) significantly decreased after pancreatectomy in the PD group (area under the curve [AUC] -9.3%, P < .01), and significantly increased in the DP population (AUC + 16.8%, P < .01). Insulin secretion rate during the 75gOGTT and glucagon stimulation test significantly decreased after pancreatectomy both in the PD and DP groups (P < .001). Both groups showed similar homeostasis model assessment of insulin resistance (HOMA-IR) values after pancreatectomy. Decrease in exocrine function quality after pancreatectomy was more marked in association with PD than DP (P < .01). Multiple regression analysis indicated that resection type and preoperative HOMA-IR independently influenced glucose tolerance-related postoperative outcomes. CONCLUSIONS: Blood glucose levels after the OGTT differed markedly between PD and DP populations. The observed differences between PD and DP suggest the importance of individualization in the management of metabolism and nutrition after partial pancreatectomy.
• Should Contrast-Enhanced Harmonic Endoscopic Ultrasound Be Incorporated into the International Consensus Guidelines to Determine the Appropriate Treatment of Intraductal Papillary Mucinous Neoplasm?

  Tomohiro Yamazaki; Mamoru Takenaka; Shunsuke Omoto; Tomoe Yoshikawa; Rei Ishikawa; Ayana Okamoto; Atsushi Nakai; Kosuke Minaga; Ken Kamata; Kentaro Yamao; Yoriaki Komeda; Tomohiro Watanabe; Naoshi Nishida; Keiko Kamei; Ippei Matsumoto; Yoshifumi Takeyama; Takaaki Chikugo; Yasutaka Chiba; Masatoshi Kudo

  Journal of clinical medicine 10 (9) 2021/04 

  This study aimed to investigate whether the incorporation of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) into the international consensus guidelines (ICG) for the management of intraductal papillary mucinous neoplasm (IPMN) could improve its malignancy diagnostic value. In this single-center retrospective study, 109 patients diagnosed with IPMN who underwent preoperative CH-EUS between March 2010 and December 2018 were enrolled. We analyzed each malignancy diagnostic value (sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV)) by replacing fundamental B-mode EUS with CH-EUS as the recommended test for patients with worrisome features (WF) (the CH-EUS incorporation ICG) and comparing the results to those obtained using the 2017 ICG. The malignancy diagnostic values as per the 2017 ICG were 78.9%, 42.3%, 60.0%, and 64.7% for Se, Sp, PPV, and NPV, respectively. The CH-EUS incorporation ICG plan improved the malignancy diagnostic values (Se 78.9%/Sp, 53.8%/PPV, 65.2%/NPV 70.0%). CH-EUS may be useful in determining the appropriate treatment strategies for IPMN.
• Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: An international multicenter study.

  Hyeong Seok Kim; Wookyeong Song; Wonho Choo; Sungyoung Lee; Youngmin Han; Claudio Bassi; Roberto Salvia; Giovanni Marchegiani; Christopher L Wolfgang; Jin He; Alex B Blair; Michael D Kluger; Gloria H Su; Song Cheol Kim; Ki-Byung Song; Masakazu Yamamoto; Takashi Hatori; Ching-Yao Yang; Hiroki Yamaue; Seiko Hirono; Sohei Satoi; Tsutomu Fujii; Satoshi Hirano; Wenhui Lou; Yasushi Hashimoto; Yasuhiro Shimizu; Marco Del Chiaro; Roberto Valente; Matthias Lohr; Dong Wook Choi; Seong Ho Choi; Jin Seok Heo; Fuyuhiko Motoi; Ippei Matsumoto; Woo Jung Lee; Chang Moo Kang; Yi-Ming Shyr; Shin-E Wang; Ho-Seong Han; Yoo-Seok Yoon; Marc G Besselink; Nadine C M van Huijgevoort; Masayuki Sho; Hiroaki Nagano; Sang Geol Kim; Goro Honda; Yinmo Yang; Hee Chul Yu; Jae Do Yang; Jun Chul Chung; Yuichi Nagakawa; Hyung Il Seo; Seungyeoun Lee; Hongbeom Kim; Wooil Kwon; Taesung Park; Jin-Young Jang

  Journal of hepato-biliary-pancreatic sciences 30 (1) 133 - 143 2021/04 

  BACKGROUND: Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms. METHODS: We recruited 3708 patients who underwent surgical resection at 31 tertiary institutions in eight countries, and patients with main pancreatic duct >10 mm were excluded. To construct the nomogram, 2606 patients were randomly allocated 1:1 into training and internal validation sets, and area under the receiver operating characteristics curve (AUC) was calculated using 10-fold cross validation by exhaustive search. This nomogram was then validated and compared to the American and Korean/Japanese nomograms using 1102 patients. RESULTS: Among the 2606 patients, 90 had main-duct type, 900 had branch-duct type, and 1616 had mixed-type IPMN. Pathologic results revealed 1628 low-grade dysplasia, 476 high-grade dysplasia, and 502 invasive carcinoma. Location, cyst size, duct dilatation, and mural nodule were selected to construct the nomogram. AUC of this nomogram was higher than the American nomogram (0.691 vs 0.664, P = .014) and comparable with the Korean/Japanese nomogram (0.659 vs 0.653, P = .255). CONCLUSIONS: A novel nomogram based on radiologic findings of IPMN is competitive for predicting risk of malignancy. This nomogram would be clinically helpful in circumstances where tumor markers are not available. The nomogram is freely available at http://statgen.snu.ac.kr/software/nomogramIPMN.
• Improved detection of liver metastasis using Kupffer-phase imaging in contrast-enhanced harmonic EUS in patients with pancreatic cancer (with video).

  Kosuke Minaga; Masayuki Kitano; Atsushi Nakai; Shunsuke Omoto; Ken Kamata; Kentaro Yamao; Mamoru Takenaka; Masakatsu Tsurusaki; Takaaki Chikugo; Ippei Matsumoto; Yasutaka Chiba; Tomohiro Watanabe; Masatoshi Kudo

  Gastrointestinal endoscopy Elsevier BV 93 (2) 433 - 441 0016-5107 2021/02 [Refereed]
   

  BACKGROUND AND AIMS: Kupffer-phase imaging visualized by perfluorobutane (Sonazoid) distribution into normal liver tissues upon phagocytosis by Kupffer cells potentially aids in improving detection of liver metastasis compared with fundamental B-mode EUS (FB-EUS). However, the diagnostic performance of Kupffer-phase imaging in contrast-enhanced harmonic EUS (CH-EUS) remains unclear. Hence, this study aimed to evaluate the usefulness of CH-EUS-based Kupffer-phase imaging for diagnosing liver metastasis from pancreatic cancer. METHODS: We retrospectively analyzed consecutive patients with pancreatic cancer who underwent contrast-enhanced CT (CE-CT) and FB-EUS, followed by CH-EUS, from 2011 to 2017. The diagnostic ability of CH-EUS against that of CE-CT and FB-EUS for metastasis in the left liver lobe was compared. Subsequently, the influences of CH-EUS on the determination of clinical stage and patient management for pancreatic cancer were assessed. RESULTS: We enrolled 426 patients with pancreatic cancer. Metastasis in the left liver lobe was present in 27.2% of patients. The diagnostic accuracy of CE-CT, FB-EUS, and CH-EUS was 90.6%, 93.4%, and 98.4%, respectively. The sensitivity and diagnostic accuracy of CH-EUS for metastasis in the left liver lobe were significantly higher than those of FB-EUS or CE-CT. The sensitivity of CH-EUS for detecting small liver metastasis (<10 mm) was considerably higher than that of CE-CT or FB-EUS (P < .001). In 2.1% of patients, only CH-EUS could detect a single distant metastasis of the left liver lobe, thereby upgrading the tumor staging and altering the clinical management. CONCLUSIONS: CH-EUS-based Kupffer-phase imaging increased the detectability of metastasis in the left liver lobe. This technique could be a reliable pretreatment imaging modality for clinical decision-making in patients with pancreatic cancer.
• 【急性膵炎診療up-to-date】治療 急性膵炎診療における地域連携モデルの構築

  大本 俊介; 竹中 完; 工藤 正俊; 松本 逸平; 竹山 宜典

  肝胆膵 (株)アークメディア 82 (1) 119 - 122 0389-4991 2021/01 

  急性膵炎の診療における地域連携モデルの構築を図った。南大阪地域の中核病院101施設へアンケート調査を行い、地域の膵炎の病期別の搬送先リスト(南大阪膵炎MAP)を作成した。各施設でさまざまな問題点の提起があり、どの病院が受け入れしてくれるかどうかが分からない、病院のどの部署へ連絡すればいいかが分からない、夜間・休日・学会開催時の受け入れが難しい病院がある、というような点があげられた。各医療機関の軽症膵炎・重症膵炎の日中および夜間の受け入れ状態を確認し、各施設を「軽症膵炎が対応可能」「重症膵炎をときに受け入れることが可能」「重症膵炎を常に受け入れることが可能」の三つのカテゴリーに分類し、転送する家族のサポートの面から転送施設から近い施設が確認しやすいように地図の形態とし「南大阪膵炎MAP」と名づけた。南大阪地域における参加施設間でこのMAPの情報を共有し現在運用を行っている。
• Conversion to open laparotomy during laparoscopic distal pancreatectomy: lessons from a single-center experience in 70 consecutive patients.

  Ippei Matsumoto; Keiko Kamei; Shumpei Satoi; Takaaki Murase; Masataka Matsumoto; Kohei Kawaguchi; Yuta Yoshida; Dongha Lee; Atsushi Takebe; Takuya Nakai; Yoshifumi Takeyama

  Surgery today 51 (1) 70 - 78 2021/01 

  PURPOSE: The purpose of this study was to determine the factors influencing conversion from laparoscopic distal pancreatectomy (LDP) to open surgery, and the effect of such conversion on the outcome. METHODS: This retrospective single-center study included 70 consecutive patients undergoing LDP. The primary endpoint was the rate of conversion to open surgery during LDP. The secondary endpoints were determining the reasons for conversion to open surgery, with detailed analyses of these cases and a comparison of the surgical outcome with and without conversion. RESULTS: Seven patients (10%) required conversion to open surgery during LDP. Pancreatic ductal adenocarcinoma (PDAC) was identified as a risk factor for conversion (p = 0.010). The reasons for conversion included technical difficulty (two bleeding, one severe adhesion) and pancreatic stump-related issues (two margin-positive, two stapling failures). Although the overall morbidity rate (29 vs. 11%, p = 0.48) and the rate of clinically relevant postoperative pancreatic fistula (14 vs. 5%, p = 0.82) were no different for the patients with or without open conversion, the postoperative hospital stay was significantly longer in the former (median 15 vs. 10 days, p = 0.03). CONCLUSIONS: Careful preoperative assessment is required when planning LDP for PDAC. Although conversion to open surgery does not result in failure of LDP, efforts to reduce the duration of postoperative hospital stay and the occurrence of complications are desirable to improve the outcome of LDP.
• Risk prediction for malignant intraductal papillary mucinous neoplasm of the pancreas: logistic regression versus machine learning.

  Jae Seung Kang; Chanhee Lee; Wookyeong Song; Wonho Choo; Seungyeoun Lee; Sungyoung Lee; Youngmin Han; Claudio Bassi; Roberto Salvia; Giovanni Marchegiani; Cristopher L Wolfgang; Jin He; Alex B Blair; Michael D Kluger; Gloria H Su; Song Cheol Kim; Ki-Byung Song; Masakazu Yamamoto; Ryota Higuchi; Takashi Hatori; Ching-Yao Yang; Hiroki Yamaue; Seiko Hirono; Sohei Satoi; Tsutomu Fujii; Satoshi Hirano; Wenhui Lou; Yasushi Hashimoto; Yasuhiro Shimizu; Marco Del Chiaro; Roberto Valente; Matthias Lohr; Dong Wook Choi; Seong Ho Choi; Jin Seok Heo; Fuyuhiko Motoi; Ippei Matsumoto; Woo Jung Lee; Chang Moo Kang; Yi-Ming Shyr; Shin-E Wang; Ho-Seong Han; Yoo-Seok Yoon; Marc G Besselink; Nadine C M van Huijgevoort; Masayuki Sho; Hiroaki Nagano; Sang Geol Kim; Goro Honda; Yinmo Yang; Hee Chul Yu; Jae Do Yang; Jun Chul Chung; Yuichi Nagakawa; Hyung Il Seo; Yoo Jin Choi; Yoonhyeong Byun; Hongbeom Kim; Wooil Kwon; Taesung Park; Jin-Young Jang

  Scientific reports 10 (1) 20140 - 20140 2020/11 

  Most models for predicting malignant pancreatic intraductal papillary mucinous neoplasms were developed based on logistic regression (LR) analysis. Our study aimed to develop risk prediction models using machine learning (ML) and LR techniques and compare their performances. This was a multinational, multi-institutional, retrospective study. Clinical variables including age, sex, main duct diameter, cyst size, mural nodule, and tumour location were factors considered for model development (MD). After the division into a MD set and a test set (2:1), the best ML and LR models were developed by training with the MD set using a tenfold cross validation. The test area under the receiver operating curves (AUCs) of the two models were calculated using an independent test set. A total of 3,708 patients were included. The stacked ensemble algorithm in the ML model and variable combinations containing all variables in the LR model were the most chosen during 200 repetitions. After 200 repetitions, the mean AUCs of the ML and LR models were comparable (0.725 vs. 0.725). The performances of the ML and LR models were comparable. The LR model was more practical than ML counterpart, because of its convenience in clinical use and simple interpretability.
• 急性膵炎におけるプレサルコペニアの臨床的意義に関しての検討

  田中 隆光; 竹中 完; 吉田 晃弘; 田中 秀和; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 中井 敦史; 大本 俊輔; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  日本消化器病学会雑誌 (一財)日本消化器病学会 117 (臨増大会) A789 - A789 0446-6586 2020/10
• 急性膵炎におけるプレサルコペニアの臨床的意義に関しての検討

  田中 隆光; 竹中 完; 吉田 晃弘; 田中 秀和; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 中井 敦史; 大本 俊輔; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  日本消化器病学会雑誌 (一財)日本消化器病学会 117 (臨増大会) A789 - A789 0446-6586 2020/10
• Pancreatic neuroendocrine tumor with stenosis of the main pancreatic duct leading to pancreatic pleural effusion: a case report.

  Yuta Yoshida; Ippei Matsumoto; Tomonori Tanaka; Kentaro Yamao; Akihiro Hayashi; Keiko Kamei; Shumpei Satoi; Atsushi Takebe; Takuya Nakai; Mamoru Takenaka; Yoshifumi Takeyama

  Surgical case reports 6 (1) 222 - 222 2020/09 

  BACKGROUND: Pancreatic pleural effusion and ascites are defined as fluid accumulation in the thoracic and abdominal cavity, respectively, due to direct leakage of the pancreatic juice. They usually occur in patients with acute or chronic pancreatitis but are rarely associated with pancreatic neoplasm. We present here an extremely rare case of pancreatic neuroendocrine tumor with stenosis of the main pancreatic duct, leading to pancreatic pleural effusion. CASE PRESENTATION: A 51-year-old man complained of dyspnea. Left-sided pleural effusion was detected on the chest X-ray. Pleural puncture was performed, and the pleural fluid indicated a high amylase content (36,854 IU/L). Hence, the patient was diagnosed with pancreatic pleural effusion. Although no tumor was detected, the computed tomography (CT) scan showed a pseudocyst and dilation of the main pancreatic duct in the pancreatic tail. Magnetic resonance cholangiopancreatography showed a fistula from the pseudocyst into the left thoracic cavity. Endoscopic retrograde pancreatic drainage was attempted; however, it failed due to stenosis in the main pancreatic duct in the pancreatic body. Endoscopic ultrasound revealed a hypoechoic mass measuring 15 × 15 mm in the pancreatic body that was not enhanced in the late phase of contrast perfusion and was thus suspected to be an invasive ductal carcinoma. The patient underwent distal pancreatectomy with splenectomy and the postoperative course was uneventful. Histopathological examination confirmed a neuroendocrine tumor of the pancreas (NET G2). The main pancreatic duct was compressed by the tumor. Increased pressure on the distal pancreatic duct by the tumor might have caused formation of the pseudocyst and pleural effusion. To the best of our knowledge, this is the first case report of pancreatic pleural effusion associated with a neuroendocrine tumor. CONCLUSIONS: Differential diagnosis of a pancreatic neoplasm should be considered, especially when a patient without a history of pancreatitis presents with pleural effusion.
• Surgical treatment for chronic pancreatitis: A single-center retrospective study in Japan.

  Ippei Matsumoto; Keiko Kamei; Takaaki Murase; Yuta Yoshida; Kohei Kawaguchi; Masataka Matsumoto; Shumpei Satoi; Atsushi Takebe; Takuya Nakai; Yoshifumi Takeyama

  Journal of hepato-biliary-pancreatic sciences 27 (9) 632 - 639 2020/09 

  BACKGROUND/PURPOSE: To determine the short- and long-term results of surgical treatments for chronic pancreatitis (CP) at a high-volume center in Japan. METHODS: The records of 151 consecutive patients undergoing surgery for CP were retrospectively reviewed. Selection of surgical procedures used had been according to the Japanese Clinical Practice Guidelines for CP 2015. Long-term (≥1 year) follow-up was performed in 100 patients (median of 37 months). RESULTS: Surgical drainage procedures were performed in 107 patients (Frey operation in 81, longitudinal pancreaticojejunostomy in 26), pancreatic resection in 37 (subtotal stomach-preserving pancreaticoduodenectomy in 11, distal pancreatectomy in 26), and other procedures in six. The rates of postoperative mortality and morbidity were 1% and 26%, respectively. The rates of complete and partial pain relief were 62% and 37%. The frequency of occurrence of severe morbidity was significantly higher after pancreatic resection than in patients receiving drainage procedures (13% vs 2%, P = .019). The rate of new-onset diabetes was also significantly higher after resection than drainage (60% vs 25%, P = .017). CONCLUSIONS: Surgical treatment for painful chronic pancreatitis can be safe and effective. An optimal procedure should guarantee pain relief and preserve a maximum of pancreatic function.
• Risk factors for pancreatic fistula grade C after pancreatoduodenectomy: A large prospective, multicenter Japan-Taiwan collaboration study.

  Seiko Hirono; Toshio Shimokawa; Yuichi Nagakawa; Yi-Ming Shyr; Manabu Kawai; Ippei Matsumoto; Sohei Satoi; Hideyuki Yoshitomi; Takehiro Okabayashi; Fuyuhiko Motoi; Ryosuke Amano; Yoshiaki Murakami; Satoshi Hirano; Kazuyuki Kawamoto; Shoji Nakamori; Yan-Shen Shan; Shinjiro Kobayashi; Hiroyuki Nitta; Hiroyoshi Matsukawa; Kazuhisa Uchiyama; Chih-Po Hsu; Chie Kitami; Masakazu Yamamoto; Tsann-Long Hwang; Hiroki Yamaue

  Journal of hepato-biliary-pancreatic sciences 27 (9) 622 - 631 2020/09 

  BACKGROUND/PURPOSE: Grade C postoperative pancreatic fistula (POPF), as defined by International Study Group of Pancreatic Fistula (ISGPF), is the most life-threatening complication after pancreatoduodenectomy (PD). This study aims to evaluate risk factors for Grade C POPF after PD. METHODS: This is a prospective, multicenter study based in Japan and Taiwan. Between December 2014 and May 2017, 3022 patients were enrolled in this study and 2762 patients were analyzed. We analyzed risk factors of Grade C POPF based on the updated 2016 ISGPF scheme (organ failure, reoperation, and/or death). RESULTS: Among 2762 patients, 46 patients (1.7%) developed Grade C POPF after PD. The mortality rate of the 46 patients with Grade C POPF was 37.0%. On the multivariate analysis, six independent risk factors for Grade C POPF were found; BMI ≥ 25.0 kg/m2 , chronic steroid use, preoperative serum albumin <3.0 mg/dL, soft pancreas, operative time ≥480 minutes, and intraoperative transfusion. The c-statistic of our risk scoring model for Grade C POPF using these risk factors was 0.77. The score was significantly higher in Grade C POPF than in Grade B POPF (P < .001) or none/biochemical leak (P < .001). CONCLUSIONS: This prospective study showed risk factors for Grade C POPF after PD.
• 切除可能膵癌の治療戦略-術前治療 vs 切除先行-【術前治療】切除可能膵癌に対する術前化学療法は標準治療となり得るか? Prep-02/JSAP-05臨床第II/III相試験結果より

  和田 慶太; 海野 倫明; 元井 冬彦; 松山 裕; 里井 壯平; 松本 逸平; 青笹 季史; 白川 博文; 藤井 努; 吉富 秀幸; 高橋 進一郎; 庄 雅之; 上野 秀樹; 小菅 智男

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 120回 DB - 1 2020/08
• Influence of the Retrocolic Versus Antecolic Route for Alimentary Tract Reconstruction on Delayed Gastric Emptying After Pancreatoduodenectomy: A Multicenter, Noninferiority Randomized Controlled Trial.

  Hirochika Toyama; Ippei Matsumoto; Takuya Mizumoto; Hirofumi Fujita; Shinobu Tsuchida; Yoshihiro Kanbara; Yoshihiko Kadowaki; Hiromi Maeda; Keiichi Okano; Masato Fukuoka; Shiro Takase; Sachiyo Shirakawa; Sachio Terai; Hideyo Mukubo; Jun Ishida; Hironori Yamashita; Kimihiko Ueno; Motofumi Tanaka; Masahiro Kido; Tetsuo Ajiki; Sae Murakami; Kunihiro Nishimura; Takumi Fukumoto

  Annals of surgery 274 (6) 935 - 944 2020/07 

  OBJECTIVE: This study aimed to determine whether retrocolic alimentary tract reconstruction is noninferior to antecolic reconstruction in terms of DGE incidence after pancreatoduodenectomy (PD) and investigated patients' postoperative nutritional status. SUMMARY OF BACKGROUND DATA: The influence of the route of alimentary tract reconstruction on DGE after PD is controversial. METHODS: Patients from 9 participating institutions scheduled for PD were randomly allocated to the retrocolic or antecolic reconstruction groups. The primary outcome was incidence of DGE, defined according to the 2007 version of the International Study Group for Pancreatic Surgery definition. Noninferiority would be indicated if the incidence of DGE in the retrocolic group did not exceed that in the antecolic group by a margin of 10%. Patients' postoperative nutrition data were compared as secondary outcomes. RESULTS: Total, 109 and 103 patients were allocated to the retrocolic and antecolic reconstruction group, respectively (n = 212). Baseline characteristics were similar between both groups. DGE occurred in 17 (15.6%) and 13 (12.6%) patients in the retrocolic and antecolic group, respectively (risk difference; 2.97%, 95% confidence interval; -6.3% to 12.6%, which exceeded the specified margin of 10%). There were no differences in the incidence of other postoperative complications and in the duration of hospitalization. Postoperative nutritional indices were similar between both groups. CONCLUSIONS: This trial could not demonstrate the noninferiority of retrocolic to antecolic alimentary tract reconstruction in terms of DGE incidence. The alimentary tract should not be reconstructed via the retrocolic route after PD, to prevent DGE.
• 膵管狭窄症例におけるCT間接所見の検討 微小膵癌と良性膵管狭窄症例の比較

  山雄 健太郎; 竹中 完; 松本 逸平; 竹山 宜典; 沼本 勲男; 鶴崎 正勝; 工藤 正俊

  膵臓 (一社)日本膵臓学会 35 (3) A345 - A345 0913-0071 2020/07
• 膵管狭窄症例におけるCT間接所見の検討 微小膵癌と良性膵管狭窄症例の比較

  山雄 健太郎; 竹中 完; 松本 逸平; 竹山 宜典; 沼本 勲男; 鶴崎 正勝; 工藤 正俊

  膵臓 (一社)日本膵臓学会 35 (3) A345 - A345 0913-0071 2020/07
• 膵全摘術の現状と展望 膵全摘後の脂肪肝発生頻度とそのリスク解析 膵全摘患者に対する前向き実態調査の結果から

  加藤 宏之; 亀井 敬子; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓 (一社)日本膵臓学会 35 (3) A117 - A117 0913-0071 2020/07
• 膵全摘術の現状と展望 膵全摘患者のQOL調査 多施設共同前向き研究結果

  亀井 敬子; 松本 逸平; 加藤 宏之; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓 (一社)日本膵臓学会 35 (3) A115 - A115 0913-0071 2020/07
• 膵全摘術の現状と展望 膵全摘術後の糖尿病コントロールと栄養指標の変化について

  須藤 広誠; 亀井 敬子; 加藤 宏之; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓 (一社)日本膵臓学会 35 (3) A118 - A118 0913-0071 2020/07
• 急性膵炎に対する局所合併症治療 Walled-off necrosisに対するLAMS with 10 FrENCD持続洗浄治療の有用性について

  竹中 完; 石川 嶺; 岡本 彩那; 中井 敦史; 山崎 友裕; 大本 俊介; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓 (一社)日本膵臓学会 35 (3) A209 - A209 0913-0071 2020/07
• 急性膵炎に対する局所合併症治療 Walled-off necrosisに対するLAMS with 10 FrENCD持続洗浄治療の有用性について

  竹中 完; 石川 嶺; 岡本 彩那; 中井 敦史; 山崎 友裕; 大本 俊介; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓 (一社)日本膵臓学会 35 (3) A209 - A209 0913-0071 2020/07
• Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients.

  Kentaro Yamao; Mamoru Takenaka; Rei Ishikawa; Ayana Okamoto; Tomohiro Yamazaki; Atsushi Nakai; Shunsuke Omoto; Ken Kamata; Kosuke Minaga; Ippei Matsumoto; Yoshifumi Takeyama; Isao Numoto; Masakatsu Tsurusaki; Takaaki Chikugo; Yasutaka Chiba; Tomohiro Watanabe; Masatoshi Kudo

  Diagnostics (Basel, Switzerland) MDPI AG 10 (7) 445 - 445 2020/07 [Refereed]
   

  BACKGROUND: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). METHODS: Nine CT findings indicating abnormalities of MPD and pancreatic parenchyma were selected as candidate findings for the presence of small PC ≤ 10 mm. The proportions of patients positive for each finding were compared between small PC and benign MPD stenosis groups. Interobserver agreement between two independent image reviewers was evaluated using kappa statistics. RESULTS: The final analysis included 24 patients with small PC (including 11 CIS patients) and 28 patients with benign MPD stenosis. The proportion of patients exhibiting partial pancreatic parenchymal atrophy (PPA) corresponding to the distribution of MPD stenosis (45.8% vs. 7.1%, p < 0.01), upstream PPA arising from the site of MPD stenosis (33.3% vs. 3.6%, p = 0.01), and MPD abrupt stenosis (45.8% vs. 14.3%, p = 0.03) was significantly higher in the small PC group than in the benign MPD stenosis group. CONCLUSIONS: The presence of partial PPA, upstream PPA, and MPD abrupt stenosis on a CT image was highly suggestive of the presence of small PCs including CIS.
• A Successful Surgical Treatment of Postoperative Hepato-Venous Fistula

  Iwasaki Toshimitsu; Matsumoto Masataka; Satoi Shumpei; Yoshida Yuta; Kawaguchi Kohei; Kamei Keiko; Takebe Atsushi; Matsumoto Ippei; Nakai Takuya; Takeyama Yoshifumi Takeyama

  International Journal of Surgery Research and Practice ClinMed International Library 7 (2) 2020/04 [Refereed]
  
• Conversion surgery after extensive chemotherapy for stage IV mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: clinical implications from the patterns of response and recurrence.

  Keiko Kamei; Junichi Shindoh; Yoshitaka Kiya; Ippei Matsumoto; Masaji Hashimoto; Yoshifumi Takeyama

  Clinical journal of gastroenterology 13 (2) 240 - 246 2020/04 

  A 53-year-old woman who was diagnosed as having advanced gallbladder cancer (T3N1M1, Stage IVB) showed a dramatic response to chemotherapy using gemcitabine + cisplatin and surgery with curative intent was attempted. Histopathological examination revealed residual tumor limited to the perimuscular connective tissue of the gallbladder (T2bN0M0, Stage IIB) and a mixture of poorly differentiated adenocarcinoma and neuroendocrine carcinoma (NEC) components was confirmed. At 6 months after the surgery, a small peritoneal nodule was detected and chemotherapy was resumed with gemcitabine, cisplatin, and S-1. However, the recurrent lesion showed no response at all and gradually formed a mass with the liver and kidney. Considering the difficulty of intensive chemotherapy and the relatively indolent progression of the disease at 15 months after the recurrence was first detected, repeat resection was performed. Histopathology of the resected lesions revealed only a NEC components. Although surgical intervention may be effective in selected cases, given that the NEC component is often associated with progression and recurrence of the disease, the chemotherapy regimen would need to include drugs for the NEC component in cases where the histopathological diagnosis of MANEC has been established.
• Efficacy of Recombinant Human-Soluble Thrombomodulin for Severe Acute Pancreatitis in a Rat Experimental Model.

  Masataka Matsumoto; Keiko Kamei; Takaaki Chikugo; Ippei Matsumoto; Kohei Kawaguchi; Yoshifumi Takeyama

  Pancreas 49 (4) 503 - 508 2020/04 

  OBJECTIVES: Early death in severe acute pancreatitis (SAP) is caused by pancreatic necrosis and multiple-organ failure due to microcirculation disorder. The aim of this study was to prove that recombinant human-soluble thrombomodulin (rTM) has therapeutic effects on SAP by preventing pancreatic necrosis and organ failure. METHODS: Male Wister rats were used. Cerulein was administered intraperitoneally 4 times every 1 hour, and lipopolysaccharide was administered intraperitoneally 3 hours after. One hour after administration of lipopolysaccharide, rTM was injected intravenously. Rats were observed for 24 hours after starting the experiment, and the survival rate was evaluated. All surviving rats were killed, and the blood sample, liver, and pancreas were excised. Serum amylase, aspartate aminotransferase, alanine aminotransferase, and high mobility group box 1 were measured, and the liver and pancreas were examined histologically. For the evaluation of microcirculation, von Willebrand factor staining was performed. RESULTS: Serum amylase, aspartate aminotransferase, and alanine aminotransferase were significantly decreased. The survival rate was significantly improved to 100%. Moreover, serum high mobility group box 1 was decreased. Liver injury and pancreatic necrosis became less severe, and microcirculation was preserved histologically. CONCLUSIONS: Early administration of rTM prevents organ failure by maintenance of microcirculation and improves prognoses of SAP.
• 【慢性膵炎診療2020】診断 早期慢性膵炎のEUS所見は特異的か 加齢や他疾患の影響は

  竹中 完; 中井 敦史; 大本 俊介; 三長 孝輔; 鎌田 研; 山雄 健太郎; 渡邉 智裕; 松本 逸平; 竹山 宜典; 工藤 正俊

  肝・胆・膵 (株)アークメディア 80 (2) 295 - 302 0389-4991 2020/02 [Refereed]
  
• 【慢性膵炎診療2020】治療・予後 膵石の内視鏡治療vs.外科治療 最近の知見

  松本 逸平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 三長 孝輔; 竹中 完; 竹山 宜典

  肝・胆・膵 (株)アークメディア 80 (2) 355 - 362 0389-4991 2020/02 [Refereed]
  
• A multicenter prospective registration study on laparoscopic pancreatectomy in Japan: report on the assessment of 1,429 patients.

  Takao Ohtsuka; Yuichi Nagakawa; Hirochika Toyama; Yutaka Takeda; Atsuyuki Maeda; Yusuke Kumamoto; Yoshiharu Nakamura; Kazuki Hashida; Goro Honda; Kengo Fukuzawa; Eiji Toyoda; Minoru Tanabe; Naoto Gotohda; Ippei Matsumoto; Tomoki Ryu; Ichiro Uyama; Toru Kojima; Michiaki Unno; Daisuke Ichikawa; Yosuke Inoue; Hiroyoshi Matsukawa; Takeshi Sudo; Kyoichi Takaori; Hiroki Yamaue; Susumu Eguchi; Munenori Tahara; Makoto Shinzeki; Hidetoshi Eguchi; Masanao Kurata; Mamoru Morimoto; Hiromitsu Hayashi; Shigeru Marubashi; Masafumi Inomata; Kenjiro Kimura; Koji Amaya; Masayuki Sho; Ryuichi Yoshida; Akihiro Murata; Hideyuki Yoshitomi; Kenichi Hakamada; Masafumi Yasunaga; Nobutsugu Abe; Masayoshi Hioki; Masaru Tsuchiya; Takeyuki Misawa; Yasuji Seyama; Hirokazu Noshiro; Eiji Sakamoto; Kiyoshi Hasegawa; Yasunari Kawabata; Yoichiro Uchida; Shinichiro Kameyama; Saiho Ko; Takashi Takao; Kenji Kitahara; Shin Nakahira; Hideo Baba; Masahiko Watanabe; Masakazu Yamamoto; Masafumi Nakamura

  Journal of hepato-biliary-pancreatic sciences 27 (2) 47 - 55 2020/02 [Refereed]
   

  BACKGROUND: Prospective studies are needed to understand the safety and feasibility of laparoscopic pancreatectomy. The aim of the present study was to describe laparoscopic pancreatectomy currently undertaken in Japan, using a prospective registration system. METHODS: Patient characteristics and planned operations were registered preoperatively, and then the performed operation and outcomes were reported using an online system. Collected data were also compared between institutions based on their level of experience. This study was registered with UMIN000022836. RESULTS: Available data were obtained from 1,429 patients at 100 Japanese institutions, including 1,197 laparoscopic distal pancreatectomies (LDPs) and 232 laparoscopic pancreatoduodenectomies (LPDs). The rates of completion for planned operations were 92% for LDP and 91% for LPD. Postoperative complication rates after LDP and LPD were 17% and 30%, and 90-day mortality rates were 0.3% and 0.4%, respectively. Shorter operation time, less blood loss, and lower incidence of pancreatic fistula were observed in institutions experienced in LDP. A higher rate of pure laparoscopic procedure and shorter operation time were noted in institutions experienced with LPD. CONCLUSION: LDPs and LPDs are performed safely in Japan, especially in experienced institutions. Our data could support the next challenges in the field of laparoscopic pancreatectomy.
• [A Case of Emergency Pancreaticoduodenectomy for Tumor Bleeding in Duodenal Cancer with Multiple Liver Metastases].

  Masataka Matsumoto; Ippei Matsumoto; Keiko Kamei; Yuta Yoshida; Kohei Kawaguchi; Takaaki Murase; Shumpei Satoi; Atsushi Takebe; Takuya Nakai; Yoshifumi Takeyama

  Gan to kagaku ryoho. Cancer & chemotherapy 47 (1) 108 - 110 0385-0684 2020/01 

  A 62 year-old female presenting with shortness of breath and severe anemia(Hb level 4.4 g/dL)was diagnosed with tumor bleeding and duodenal cancer by gastrointestinal endoscopy.Computed tomography scan revealed multiple liver metastases.After admission, the Hb level dropped from 9.1 g/dL to 5.1 g/dL in one night, and emergency pancreaticoduodenectomy( PD)was performed to control the bleeding.The postoperative course was uneventful, and the patient was discharged on postoperative day(POD)16.Systemic chemotherapy was initiated 1 month after surgery, but the patient died from the disease 13 months after surgery.Emergency PD could be a treatment option in patients with uncontrolled tumor bleeding and fatal conditions.
• 慢性膵炎臨床診断基準2019

  正宗 淳; 入澤 篤志; 菊田 和宏; 池浦 司; 伊佐地 秀司; 石黒 洋; 糸井 隆夫; 伊藤 鉄英; 乾 和郎; 大原 弘隆; 片岡 慶正; 神澤 輝実; 岸和田 昌之; 北野 雅之; 阪上 順一; 佐田 尚宏; 清水 京子; 竹中 完; 竹山 宜典; 能登原 憲司; 廣岡 芳樹; 松本 逸平; 宮川 宏之; 岡崎 和一; 日本膵臓学会, 日本膵臓学会膵炎調査研究委員会慢性膵炎分科会

  膵臓 (一社)日本膵臓学会 34 (6) 279 - 281 0913-0071 2019/12
• 【慢性膵炎臨床診断基準2019】「慢性膵炎臨床診断基準2019」の背景と概要

  正宗 淳; 入澤 篤志; 菊田 和宏; 池浦 司; 伊佐地 秀司; 石黒 洋; 糸井 隆夫; 伊藤 鉄英; 乾 和郎; 大原 弘隆; 片岡 慶正; 神澤 輝実; 岸和田 昌之; 北野 雅之; 阪上 順一; 佐田 尚宏; 清水 京子; 竹中 完; 竹山 宜典; 能登原 憲司; 廣岡 芳樹; 松本 逸平; 宮川 宏之; 岡崎 和一; 日本膵臓学会膵炎調査研究委員会慢性膵炎分科会

  膵臓 (一社)日本膵臓学会 34 (6) 282 - 292 0913-0071 2019/12 

  現行の「慢性膵炎臨床診断基準2009」が提唱されてから10年間が経過した。世界ではじめて早期慢性膵炎の概念を取り入れた診断基準であるが、その後蓄積された知見や膵炎診療の変化をふまえて、その改訂が必要となっていた。今回、日本膵臓学会膵炎調査研究委員会慢性膵炎分科会が中心となり、診断基準の改訂を行った。新基準「慢性膵炎臨床診断基準2019」の最大の特徴は、mechanistic definitionを慢性膵炎の概念として取り入れ、早期慢性膵炎の診断項目を危険因子の観点から改訂したことである。新たに膵炎関連遺伝子異常と急性膵炎の既往を診断項目に組み入れ、診断特異度の向上を意図した。さらに、多量飲酒歴の基準を純エタノール換算80g/日から60g/日に変更するとともに、画像診断としてMRCP所見の格上げ、早期慢性膵炎の画像所見の整理を行った。新しい診断基準が慢性膵炎診療のさらなる質の向上や患者の予後改善に寄与することが期待される。(著者抄録)
• Transpancreatic mattress suture with Vicryl mesh around the stump decreases postoperative pancreatic fistula after distal pancreatectomy.

  Yuta Yoshida; Ippei Matsumoto; Masataka Matsumoto; Kohei Kawaguchi; Takaaki Murase; Keiko Kamei; Shumpei Satoi; Atsushi Takebe; Takuya Nakai; Yoshifumi Takeyama

  Journal of hepato-biliary-pancreatic sciences 26 (11) 510 - 516 1868-6974 2019/11 [Refereed]
   

  BACKGROUND: Postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) remains the most common surgical complication. We have developed a novel stump closure technique after DP using transpancreatic mattress suture with Vicryl mesh (TMV) and reported our initial findings. The purpose of this study is to evaluate the efficacy of TMV compared to the conventional handsewn stump closure technique (CHS). METHODS: This retrospective single-center study included 165 consecutive patients who underwent open DP from January 2010 to May 2018. Of these, 71 patients underwent DP using TMV after September 2014 and 94 patients underwent DP with CHS. The surgical outcomes were compared between the two groups. RESULTS: Clinically relevant POPF rate in the TMV group was significantly lower than that in the CHS group (5.6% vs. 17.2%, P = 0.027). Morbidity rate was higher in the CHS group than that in the TMV group (16.9% vs. 27.7%, P = 0.104). In the multivariate analysis, absence of additional organ resection (OR 3.57; 95% CI 1.18-10.43; P = 0.025) and TMV (OR 0.24; 95% CI 0.07-0.73; P = 0.010) were identified as independent preventing factors for clinically relevant POPF. CONCLUSION: TMV can be an effective stump closure technique for preventing POPF after DP.
• R0切除後CA19-9遷延上昇は、膵癌術後肝転移再発の高リスク徴候である

  元井 冬彦; 村上 義昭; 松本 逸平; 里井 壯平; 庄 雅之; 本田 五郎; 福本 巧; 青木 修一; 水間 正道; 山上 裕機; 海野 倫明

  日本癌治療学会学術集会抄録集 (一社)日本癌治療学会 57回 O49 - 3 2019/10
• Laparoscopic versus open distal pancreatectomy for benign and low-grade malignant lesions of the pancreas: a single-center comparative study.

  Ippei Matsumoto; Keiko Kamei; Shumpei Satoi; Takaaki Murase; Masataka Matsumoto; Kohei Kawaguchi; Yuta Yoshida; Toshimitsu Iwasaki; Atsushi Takebe; Takuya Nakai; Yoshifumi Takeyama

  Surgery today 49 (5) 394 - 400 0941-1291 2019/05 [Refereed]
   

  PURPOSE: The purpose of the study was to compare the outcomes of laparoscopic distal pancreatectomy (LDP) and open distal pancreatectomy (ODP) for benign and low-grade malignant lesions to determine the safety and efficacy of LDP. METHODS: This retrospective comparative study included 67 consecutive patients who underwent LDP (n = 32) and ODP (n = 35) for benign or low-grade malignant lesions of the pancreas from January 2012 to March 2017. Thirty-five patients who were eligible for LDP in the ODP group were carefully selected. The clinical outcomes were compared in an intention-to-treat analysis. RESULTS: LDP was associated with significantly less operative blood loss (182 ± 232 vs. 505 ± 376 ml, P < 0.001) but a longer operation time (327 ± 89 vs. 173 ± 48 min, P < 0.001), than ODP. There were no significant differences between the 2 groups in the overall morbidity rates defined by Clavien-Dindo classification ≥ grade II (13% vs. 11%), clinically relevant postoperative pancreatic fistula rates (6% vs. 9%), and lengths of postoperative hospital stay (11 vs. 11 days). CONCLUSION: The study showed that LDP was safe and feasible. LDP should be considered as the first-line treatment for benign and low-grade malignant lesions in the left side of the pancreas.
• Decreased serum carbohydrate antigen 19-9 levels after neoadjuvant therapy predict a better prognosis for patients with pancreatic adenocarcinoma: a multicenter case-control study of 240 patients.

  Shuichi Aoki; Fuyuhiko Motoi; Yoshiaki Murakami; Masayuki Sho; Sohei Satoi; Goro Honda; Kenichiro Uemura; Ken-Ichi Okada; Ippei Matsumoto; Minako Nagai; Hiroaki Yanagimoto; Masanao Kurata; Takumi Fukumoto; Masamichi Mizuma; Hiroki Yamaue; Michiaki Unno

  BMC cancer 19 (1) 252 - 252 2019/03 [Refereed]
   

  BACKGROUND: Carbohydrate antigen (CA) 19-9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19-9 levels after neoadjuvant therapy has not been clarified. This study aimed to define the prognostic significance of decreased CA19-9 levels after neoadjuvant therapy in patients with pancreatic adenocarcinoma. METHODS: Between 2001 and 2012, 240 consecutive patients received neoadjuvant therapy and subsequent resection at seven high-volume institutions in Japan. These patients were divided into three groups: Normal group (no elevation [≤37 U/ml] before and after neoadjuvant therapy), Responder group (elevated levels [> 37 U/ml] before neoadjuvant therapy but decreased levels [≤37 U/ml] afterwards), and Non-responder group (elevated levels [> 37 U/ml] after neoadjuvant therapy). Analyses of overall survival and recurrence patterns were performed. Uni- and multivariate analyses were performed to clarify the clinicopathological factors influencing overall survival. The initial metastasis sites were also evaluated in these groups. RESULTS: The Responder group received a better prognosis than the Non-responder group (3-year overall survival: 50.6 and 41.6%, respectively, P = 0.026), but the prognosis was comparable to the Normal group (3-year overall survival: 54.2%, P = 0.934). According to the analysis of the receiver operating characteristic curve, the CA19-9 cut-off level defined as no elevation after neoadjuvant therapy was ≤103 U/ml. The multivariate analysis revealed that a CA19-9 level ≤ 103 U/ml, (P = 0.010, hazard ratio: 1.711; 95% confidence interval: 1.133-2.639), tumor size ≤27 mm (P = 0.040, 1.517; (1.018-2.278)), a lack of lymph node metastasis (P = 0.002, 1.905; (1.276-2.875)), and R0 status (P = 0.045, 1.659; 1.012-2.627) were significant predictors of overall survival. Moreover, the Responder group showed a lower risk of hepatic recurrence (18%) compared to the Non-responder group (31%), though no significant difference in loco-regional, peritoneal or other distant recurrence were observed between groups (P = 0.058, P = 0.700 and P = 0.350, respectively). CONCLUSIONS: Decreased CA19-9 levels after neoadjuvant therapy predicts a better prognosis, with low incidence of hepatic recurrence after surgery.
• FOLFIRINOX for locally advanced pancreatic cancer: Results and prognostic factors of subset analysis from a nation-wide multicenter observational study in Japan.

  Ippei Matsumoto; Keiko Kamei; Katsuhiro Omae; Shuhei Suzuki; Hidehiko Matsuoka; Nobumasa Mizuno; Masato Ozaka; Hideki Ueno; Satoshi Kobayashi; Kazuhiro Uesugi; Marina Kobayashi; Akiko Todaka; Akira Fukutomi

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 19 (2) 296 - 301 1424-3903 2019/03 [Refereed]
   

  BACKGROUND: FOLFIRINOX (oxaliplatin, irinotecan, 5-fluorouracil, leucovorin) treatment significantly improved overall survival in the recent phase III study and became a standard therapy for metastatic pancreatic cancer. However, treatment for locally advanced pancreatic cancer is still controversial. We conducted subset analyses from a nation-wide multicenter observational study in Japan to evaluate the tolerability and efficacy of FOLFIRINOX in patients with locally advanced pancreatic cancer and to investigate independent prognostic factors with pre-treatment variables. METHODS: The study included 66 patients with unresectable locally advanced pancreatic cancer from 27 institutions in Japan who received FOLFIRINOX as first-line treatment between December 20, 2013 and December 19, 2014 and surveyed until December 2015. RESULTS: The median age was 63 with the Eastern Cooperative Oncology Group performance status of 0 or 1. Major Grade 3 or 4 adverse events included neutropenia (64%), leukopenia (33%), febrile neutropenia (15%), and diarrhea (15%). Severe adverse event occurred in 14 patients (11%) without fatal event. The median overall survival and progression-free survival times were 18.5 and 7.6 months, respectively. The objective response rate 15.2% and the disease control rate was 81.9%. A high modified Glasgow prognostic score (mGPS, ≥1) (95%CI 1.96-12.5) and female (95%CI 0.20-0.97) were identified as independent poor prognostic factors. CONCLUSIONS: First-line FOLFIRINOX treatment for locally advanced pancreatic cancer seems to be effective with acceptable toxicities. A high mGPS may be associated with poor survival in patients with locally advanced pancreatic cancer who receive FOLFIRINOX. This study was registered at the UMIN Clinical Trials Registry (UMIN000014658).
• 慢性膵炎急性増悪の治療中に発症した意識障害

  川口晃平; 松本逸平; 柏木伸夫; 竹山宜典

  日本消化器病学会雑誌 116 (2) S1 - S3 2019/02 [Refereed]
  
• A single-arm, phase II trial of neoadjuvant gemcitabine and S1 in patients with resectable and borderline resectable pancreatic adenocarcinoma: PREP-01 study.

  Fuyuhiko Motoi; Sohei Satoi; Goro Honda; Keita Wada; Hiroyuki Shinchi; Ippei Matsumoto; Masayuki Sho; Akihiko Tsuchida; Michiaki Unno

  Journal of gastroenterology 54 (2) 194 - 203 0944-1174 2019/02 [Refereed]
   

  BACKGROUND: Neoadjuvant chemotherapy (NAC) represents a promising alternative to pancreatic ductal adenocarcinoma (PDAC) planned resection, but the survival impact remains undefined. To assess the feasibility and survival outcomes of NAC with gemcitabine and S1 (GS) for PDAC planned resection by prospective study. METHODS: Patients with resectable or borderline resectable PDAC received 2 cycles of NAC-GS and were offered curative resection followed by gemcitabine adjuvant. The primary endpoint was 2-year overall survival (OS). Adverse events during NAC, radiological and tumor marker responses, resection rate, and surgical safety were evaluated as secondary endpoints (UMIN000004148). RESULTS: We enrolled 104 patients between 2010 and 2012, with 101 patients treated using NAC-GS as the full analysis set (FAS). Of the 101 patients, 88% received the planned 2 cycles of NAC. Grade 3 neutropenia was common (35%). Radiological partial response and decreased carbohydrate antigen 19-9 concentration (> 50% decrease) were noted in 13% and 41%, respectively. R0/1 resections with M0 were performed in 65 patients without surgical mortality. Of the 65 patients, 44 received planned gemcitabine adjuvant for 6 months as the on-protocol cohort. The primary endpoint for the 2-year OS rate was 55.9% in the FAS (n = 101) and 74.6% in the on-protocol cohort (n = 44). CONCLUSIONS: NAC-GS was feasible and actively prolonged survival following PDAC planned resection. Randomized control trials are needed to further clarify the survival benefit of NAC-GS in addition to surgery followed by adjuvant therapy.
• Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05).

  Fuyuhiko Motoi; Tomoo Kosuge; Hideki Ueno; Hiroki Yamaue; Sohei Satoi; Masayuki Sho; Goro Honda; Ippei Matsumoto; Keita Wada; Junji Furuse; Yutaka Matsuyama; Michiaki Unno

  Japanese journal of clinical oncology 49 (2) 190 - 194 2019/02 [Refereed]
   

  A randomized, controlled trial has begun to compare neoadjuvant chemotherapy using gemcitabine and S-1 with upfront surgery for patients planned resection of pancreatic cancer. Patients were enrolled after the diagnosis of resectable or borderline resectable by portal vein involvement pancreatic cancer with histological confirmation. They were randomly assigned to either neoadjuvant chemotherapy or upfront surgery. Adjuvant chemotherapy using S-1 was administered for 6 months to patients with curative resection who fully recovered within 10 weeks after surgery in both arms. The primary endpoint is overall survival; secondary endpoints include adverse events, resection rate, recurrence-free survival, residual tumor status, nodal metastases and tumor marker kinetics. The target sample size was required to be at least 163 (alpha-error 0.05; power 0.8) in both arms. A total of 360 patients were required after considering ineligible cases. This trial began in January 2013 and was registered with the UMIN Clinical Trials Registry (UMIN000009634).
• Sustained Elevation of Postoperative Serum Level of Carbohydrate Antigen 19-9 is High-Risk Stigmata for Primary Hepatic Recurrence in Patients with Curatively Resected Pancreatic Adenocarcinoma.

  Fuyuhiko Motoi; Yoshiaki Murakami; Ken-Ichi Okada; Ippei Matsumoto; Kenichiro Uemura; Sohei Satoi; Masayuki Sho; Goro Honda; Takumi Fukumoto; Hiroaki Yanagimoto; Shoichi Kinoshita; Masanao Kurata; Shuichi Aoki; Masamichi Mizuma; Hiroki Yamaue; Michiaki Unno

  World journal of surgery 43 (2) 634 - 641 0364-2313 2019/02 [Refereed]
   

  BACKGROUND: Survival after surgery for pancreatic adenocarcinoma (PA) is poor and heterogeneous, even for curative (R0) resection. Serum carbohydrate antigen (CA) 19-9 levels are important prognostic markers for resected PA. However, sustained elevation of CA19-9 in association with the patterns of recurrence has been rarely investigated. METHODS: Patients who underwent R0 resection (n = 539) were grouped according to postoperative serum CA19-9 levels (Group E: sustained elevation; Group N: no elevation). Clinicopathological factors, patterns of recurrence, and survival were compared between the groups. RESULTS: Group E (n = 159) had significantly shorter median overall survival (17.1 vs. 35.4 months, p < 0.0001) than Group N (n = 380). Postoperative CA19-9 elevation was a significant independent predictor of poor survival in multivariate analysis (hazard ratio 1.98, p < 0.0001). The rate of hepatic recurrence in Group E was 2.6-fold higher than in Group N (45% vs. 17%, p < 0.0001). Postoperative CA19-9 elevation was a strongest independent predictor of primary hepatic recurrence (p < 0.0001) by a multiple regression model. Loco-regional, peritoneal, and other distant recurrence did not differ between the groups. The extent of preoperative CA19-9 elevation was correlated sustained elevation of CA19-9 after surgery (p < 0.0001) and primary hepatic recurrence (p = 0.0019). CONCLUSIONS: Sustained CA19-9 elevation was strong predictor of primary hepatic recurrence and short survival in cases of R0 resection for PA.
• 【膵神経内分泌腫瘍-診断と治療のパラダイムシフト-】 外科治療 膵神経内分泌腫瘍の外科治療前にわかる予後予測因子

  南野佳英; Toyama Hirochika; 松本逸平; Fukumoto Takumi

  肝・胆・膵 (株)アークメディア 78 (1号) 79 - 86 0389-4991 2019/01 [Refereed]
  
• Identification of aberrant subvesical bile duct by using intraoperative fluorescent cholangiography: A case report.

  Toshimitsu Iwasaki; Yoshifumi Takeyama; Yuta Yoshida; Kohei Kawaguchi; Masataka Matsumoto; Takaaki Murase; Keiko Kamei; Atsushi Takebe; Ippei Matsumoto; Takuya Nakai

  International journal of surgery case reports 61 115 - 118 2019 [Refereed]
   

  INTRODUCTION: Aberrant subvesical bile ducts are rare structural anomaly located in the peri-hepatic gallbladder fossa. This duct poses the risk for intraoperative bile duct injury resulting in clinically relevant bile leakage. PRESENTATION OF CASE: Aberrant subvesical bile duct was detected by preoperative magnetic resonance cholangiopancreatography in a 52-year old woman with gallbladder polypoid tumor harboring the risk to be gallbladder cancer. During open cholecystectomy with full thickness dissection, the aberrant duct was identified by intraoperative fluorescent cholangiography (IFC), and dissected safely. DISCUSSION: Aberrant subvesical bile ducts are mostly found unexpectedly as intra and/or postoperative bile leakage, and remain an important cause of bile duct injuries after laparoscopic cholecystectomy. IFC, which offers real-time imaging of biliary anatomy, has a potential to overcome these problems. CONCLUSION: We performed cholecystectomy by using IFC to identify the aberrant subvesical bile duct. To the best of our knowledge, this is the first report showing the fluorescence image of an aberrant subvesical bile duct in a state of nature.
• 膵管内乳頭粘液性腫瘍術後フォローアップにおけるEUSの有用性

  鎌田 研; 竹中 完; 三長 孝輔; 大本 俊介; 宮田 剛; 山雄 健太郎; 今井 元; 中井 敦史; 田中 秀和; 千葉 康敬; 渡邉 智裕; 櫻井 俊治; 西田 直生志; 筑後 考章; 松本 逸平; 竹山 宜典; 北野 雅之; 工藤 正俊

  Gastroenterological Endoscopy (Web) 61 (4) 417 - 426 1884-5738 2019 [Refereed]
  
• Neurilemmoma Mimicking a Multilocular Cystic Lesion of the Liver.

  Akihiro Yoshida; Kentaro Yamao; Mamoru Takenaka; Atsushi Nakai; Shunsuke Omoto; Ken Kamata; Kosuke Minaga; Takeshi Miyata; Hajime Imai; Ippei Matsumoto; Yoshihumi Takeyama; Takaaki Chikugo; Masatoshi Kudo

  Internal medicine (Tokyo, Japan) 57 (23) 3377 - 3380 0918-2918 2018/12 [Refereed]
   

  Neurilemmomas are benign tumors arising from the sheaths of peripheral nerves. They appear rarely in the abdominal cavity. We herein report an 80-year-old man with a multilocular cystic neurilemmoma mimicking a liver lesion. Preoperative images showed a lesion in the porta hepatis. Although a preoperative diagnosis was difficult, surgery was undertaken because of the possibility of malignancy. Histologically, the tumor consisted of spindle-shaped cells with positivity for S-100 protein. The final diagnosis was a neurilemmoma. Porta hepatic neurilemmomas are rare. When we encounter a multilocular cystic lesion of the liver, neurilemmoma should be considered in the differential diagnosis.
• MAPLE-PD trial (Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer during Pancreaticoduodenectomy): study protocol for a multicenter randomized controlled trial of 354 patients with pancreatic ductal adenocarcinoma.

  Seiko Hirono; Manabu Kawai; Ken-Ichi Okada; Tsutomu Fujii; Masayuki Sho; Sohei Satoi; Ryosuke Amano; Hidetoshi Eguchi; Yuko Mataki; Masafumi Nakamura; Ippei Matsumoto; Hideo Baba; Masaji Tani; Yasunari Kawabata; Yuichi Nagakawa; Suguru Yamada; Yoshiaki Murakami; Toshio Shimokawa; Hiroki Yamaue

  Trials 19 (1) 613 - 613 2018/11 [Refereed]
   

  BACKGROUND: The mesenteric approach is an artery-first approach to pancreaticoduodenectomy for pancreatic cancer, which starts with the dissection of connective tissues around the superior mesenteric artery. The procedure aims for early confirmation of resectability by checking the surgical margin around the superior mesenteric artery first during the operation. It also aims to decrease intraoperative blood loss by early ligation of the inferior pancreaticoduodenal artery and to increase R0 rate by complete clearance of the lymph nodes around the superior mesenteric artery and pancreatic head plexus II, the most favorable positive margin site for pancreatic ductal adenocarcinoma. Furthermore, it aims to avoid the spread of cancer cells during operation (nontouch isolation technique). The MAPLE-PD (Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer during Pancreaticoduodenectomy) trial investigates whether the mesenteric approach can prolong the survival of patients with pancreatic ductal adenocarcinoma who undergo pancreaticoduodenectomy compared with the conventional approach. METHODS/DESIGN: The MAPLE-PD trial is a Japanese multicenter randomized controlled trial that compares the surgical outcomes between the mesenteric and conventional approaches to pancreaticoduodenectomy. Patients with pancreatic ductal adenocarcinoma scheduled to undergo pancreaticoduodenectomy are randomized before operation to either a conventional approach (arm A) or a mesenteric approach (arm B). In arm A, the operation starts with Kocher's maneuver. At the final step of the removal procedure, the connective tissues around the superior mesenteric artery are dissected. In arm B, the operation starts with dissection of the connective tissues around the superior mesenteric artery and ends with Kocher's maneuver. In total, 354 patients from 15 Japanese high-volume centers will be randomized. The primary endpoint is overall survival by intention-to-treat analysis. Secondary endpoints include intraoperative blood loss, R0 rate, and recurrence-free survival. DISCUSSION: If the MAPLE-PD trial shows the oncological benefits of the mesenteric approach for patients with pancreatic ductal adenocarcinoma, this procedure may become a standard approach to pancreaticoduodenectomy. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03317886 . Registered on 23 October 2017. University Hospital Medical Information Network Clinical Trials Registry, UMIN000029615 . Registered on 15 January 2018.
• Growth velocity of the portal vein tumor thrombus accelerated by its progression, alpha-fetoprotein level, and liver fibrosis stage in patients with hepatocellular carcinoma.

  Hidetoshi Gon; Masahiro Kido; Motofumi Tanaka; Hisoka Kinoshita; Shohei Komatsu; Daisuke Tsugawa; Masahide Awazu; Hirochika Toyama; Ippei Matsumoto; Tomoo Itoh; Takumi Fukumoto

  Surgery 164 (5) 1014 - 1022 2018/11 [Refereed]
   

  BACKGROUND: Progression of portal vein tumor thrombus directly affects the prognosis and treatment for patients with hepatocellular carcinoma; there are no data on the growth velocity of portal vein tumor thrombus. We analyzed the growth velocity of portal vein tumor thrombus and its risk factors to propose the best timing of surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus. METHODS: We retrospectively collected data on 57 hepatocellular carcinoma patients with portal vein tumor thrombus who underwent computed tomography twice preoperatively and hepatectomy between 2005 and 2015. To calculate the growth velocity of portal vein tumor thrombus, migration lengths of portal vein tumor thrombus were divided by the number of days. To identify risk factors for rapid growth of portal vein tumor thrombus, patients were classified according to the velocity: rapid (≥ 1.0 mm/day, n = 23) and slow (< 1.0 mm/day, n = 34). RESULTS: Median survival times of patients with portal vein tumor thrombus that invaded the ipsilateral second portal branch, ipsilateral first portal branch, and portal trunk were 42.9, 11.7, and 12.3 months, respectively. The average growth velocity of portal vein tumor thrombus was 0.9 ± 1.0 mm/day. Median estimated times required from ipsilateral second portal branch to ipsilateral first portal branch and ipsilateral first portal branch to portal trunk were 8.2 and 11.5 days, respectively. Liver fibrosis, alpha-fetoprotein, and extent of portal vein tumor thrombus were independent risk factors for rapid progression of portal vein tumor thrombus. Proteins induced by vitamin K absence or antagonist II, extent of portal vein tumor thrombus, and liver fibrosis, not rapid growth of portal vein tumor thrombus, were independent prognostic factors. CONCLUSION: An understanding of the rapid progression of portal vein tumor thrombus and its risk factors can be helpful in deciding an appropriate timing of surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus.
• 膵癌の門脈浸潤診断における造影ハーモニックEUSと造影CTの診断能の比較検討

  中井 敦史; 鎌田 研; 竹中 完; 石川 嶺; 岡本 彩那; 大本 俊介; 三長 孝輔; 山雄 健太郎; 兵頭 朋子; 松本 逸平; 竹山 宜典; 工藤 正俊

  Gastroenterological Endoscopy (一社)日本消化器内視鏡学会 60 (Suppl.2) 2126 - 2126 0387-1207 2018/10
• Insulin deficiency with and without glucagon: A comparative study between total pancreatectomy and type 1 diabetes.

  Fumimaru Niwano; Yoshihisa Hiromine; Shinsuke Noso; Naru Babaya; Hiroyuki Ito; Sara Yasutake; Ippei Matsumoto; Yoshifumi Takeyama; Yumiko Kawabata; Hiroshi Ikegami

  Journal of diabetes investigation 9 (5) 1084 - 1090 2040-1116 2018/09 [Refereed]
   

  AIMS/INTRODUCTION: Patients with a total pancreatectomy and type 1 diabetes are similar in regard to absolute insulin deficiency, but different in regard to glucagon, providing a unique opportunity to study the contribution of glucagon to glucose metabolism in an insulin-dependent state. The aim of the present study was to investigate the contribution of glucagon to glucose homeostasis in complete insulin deficiency in vivo. METHODS: A total of 38 individuals with a complete lack of endogenous insulin (fasting C-peptide <0.0066 nmol/L) and whose glycemic control was optimized with an insulin pump during hospitalization were retrospectively studied. The basal insulin requirement, time-to-time adjustment of the basal insulin infusion rate, prandial insulin requirement and fasting plasma glucagon were compared between patients with a total pancreatectomy (n = 10) and those with type 1 diabetes (n = 28) after achievement of optimal glycemic control. RESULTS: Total daily insulin (P = 0.03) and basal insulin (P = 0.000006), but not prandial insulin requirements, were significantly lower in total pancreatectomy patients than in type 1 diabetes patients. The basal percentage (basal insulin/total daily insulin) was also significantly lower in total pancreatectomy patients than in type 1 diabetes patients (15.8 ± 7.8 vs 32.9 ± 10.1%, P = 0.00003). An increase in the insulin infusion rate early in the morning was not necessary in most patients with a pancreatectomy. The fasting plasma glucagon concentration was significantly lower in total pancreatectomy patients than in type 1 diabetes patients (P = 0.00007), and was positively correlated with the basal insulin requirement (P = 0.038). CONCLUSIONS: The difference in insulin requirements between total pancreatectomy and type 1 diabetes patients suggests a contribution of glucagon to the basal insulin requirement and dawn phenomenon.
• Value of additional endoscopic ultrasonography for surveillance after surgical removal of intraductal papillary mucinous neoplasms.

  Ken Kamata; Mamoru Takenaka; Kosuke Minaga; Shunsuke Omoto; Takeshi Miyata; Kentaro Yamao; Hajime Imai; Atsushi Nakai; Hidekazu Tanaka; Yasutaka Chiba; Tomohiro Watanabe; Toshiharu Sakurai; Naoshi Nishida; Takaaki Chikugo; Ippei Matsumoto; Yoshifumi Takeyama; Masayuki Kitano; Masatoshi Kudo

  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society Wiley 30 (5) 659 - 666 0915-5635 2018/09 [Refereed]
   

  BACKGROUND AND AIM: This study evaluated the utility of endoscopic ultrasonography (EUS) combined with contrast-enhanced harmonic EUS (CH-EUS) for surveillance of the remnant pancreas after surgery for intraductal papillary mucinous neoplasm (IPMN). METHODS: This was a single-center, retrospective, descriptive study. A total of 134 consecutive patients who underwent surgical resection for IPMN between April 2009 and March 2015 were evaluated. Rates of recurrence and development of IPMN-concomitant pancreatic ductal adenocarcinoma (PDAC) during follow up were assessed. Clinical findings of patients with recurrence or development of PDAC were also evaluated. RESULTS: Of 134 resected IPMN 56 (41.8%) and 78 (58.2%) were classified as benign and malignant, respectively. Patients were followed up for a median of 29 months, 33 (24.6%) by both contrast-enhanced computed tomography (CE-CT) and EUS, and 101 (75.4%) by computed tomography (CT) alone. Thirteen patients (9.7%) showed tumor recurrence, five with intra-pancreatic recurrence and eight with extra-pancreatic metastases. An enhancing mural nodule within the dilated main pancreatic duct was successfully detected by EUS in one patient, but not by CE-CT. Two patients developed IPMN-concomitant PDAC during follow up. EUS combined with CH-EUS successfully detected small IPMN-concomitant PDAC in two patients, whereas these lesions were not detected by CT. CH-EUS was useful for better visualization of the margins of IPMN-concomitant PDAC in one of these two patients. CONCLUSION: Endoscopic ultrasonography combined with CH-EUS may improve follow up of patients with resected IPMN.
• Clinical impact of developing better practices at the institutional level on surgical outcomes after distal pancreatectomy in 1515 patients: Domestic audit of the Japanese Society of Pancreatic Surgery.

  Sohei Satoi; Tomohisa Yamamoto; Fuyuhiko Motoi; Ippei Matsumoto; Hideyuki Yoshitomi; Ryosuke Amano; Munenori Tahara; Yoshiaki Murakami; Hidehito Arimitsu; Seiko Hirono; Masayuki Sho; Hironori Ryota; Masayuki Ohtsuka; Michiaki Unno; Yoshifumi Takeyama; Hiroki Yamaue

  Annals of gastroenterological surgery 2 (3) 212 - 219 2018/05 [Refereed]
   

  Background and Aim: Institutional standardization in the perioperative management of distal pancreatectomy (DP) has not been evaluated in a multicenter setting. The aim of the present study was to assess the influence of institutional standardization on the development of postoperative complications after DP. Methods: Data were collected from 1515 patients who underwent DP in 2006, 2010, and 2014 at 53 institutions in Japan. A standardized institution (SI) was defined as one that implemented ≥6 of 11 quality initiatives according to departmental policy. There were 541 patients in the SI group and 974 in the non-SI group. Clinical parameters were compared between groups. Risk factors for morbidity and mortality were assessed by logistic regression analysis with a mixed-effects model. Results: Proportion of patients who underwent DP in SI increased from 16.5% in 2006 to 46.4% in 2014. The SI group experienced an improved process of care and a lower frequency of severe complications vs the non-SI group (grade III/IV Clavien-Dindo; 22% vs 29%, respectively, clinically relevant postoperative pancreatic fistula; 22% vs 31%, respectively, P < .05 for both). Duration of in-hospital stay in the SI group was significantly shorter than that in the non-SI group (16 [5-183] vs 20 postoperative days [5-204], respectively; P = .002). Multivariate analysis with a mixed-effects model showed that soft pancreas, late drain removal, excess blood loss and long surgical time were risk factors for post-DP complications (P < .05). Pancreatic texture, drain management and surgical factors, but not standardization of care, were associated with a lower incidence of post-DP complications.
• 膵頭十二指腸切除術における周術期管理標準化は術後合併症に影響を与えるか? 日本膵切研究会アンケート調査結果報告

  里井 壯平; 山本 智久; 吉富 秀幸; 元井 冬彦; 廣野 誠子; 藤井 努; 和田 慶太; 有光 秀仁; 庄 雅之; 松本 逸平; 平野 聡; 柳本 泰明; 大塚 将之; 海野 倫明; 山上 裕機; 權 雅憲

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 118回 1285 - 1285 2018/04 [Refereed]
  
• Health-related quality of life of adjuvant chemotherapy with S-1 versus gemcitabine for resected pancreatic cancer: Results from a randomised phase III trial (JASPAC 01).

  Yasuhiro Hagiwara; Yasuo Ohashi; Katsuhiko Uesaka; Narikazu Boku; Akira Fukutomi; Yukiyasu Okamura; Masaru Konishi; Ippei Matsumoto; Yuji Kaneoka; Yasuhiro Shimizu; Shoji Nakamori; Hirohiko Sakamoto; Soichiro Morinaga; Osamu Kainuma; Koji Imai; Naohiro Sata; Shoichi Hishinuma; Hitoshi Ojima; Ryuzo Yamaguchi; Satoshi Hirano; Takeshi Sudo

  European journal of cancer (Oxford, England : 1990) 93 79 - 88 0959-8049 2018/04 [Refereed]
   

  BACKGROUND: Adjuvant chemotherapy with S-1 for resected pancreatic cancer demonstrated survival benefits compared with gemcitabine in the JASPAC 01 trial. We investigated the effect of these agents on health-related quality of life (HRQOL) of patients in the JASPAC 01 trial. METHODS: Patients with resected pancreatic cancer were randomly assigned to receive gemcitabine (1000 mg/m2 weekly for three of four weeks for up to six cycles) or S-1 (40, 50, or 60 mg twice daily for four of six weeks for up to four cycles). HRQOL was assessed using the EuroQol-5D-3L (EQ-5D) questionnaire at baseline, months three and six, and every 6 months thereafter. HRQOL end-points included change in EQ-5D index from baseline, responses to five items in the EQ-5D, and quality-adjusted life months up to 24 months. RESULTS: Of randomised 385 patients, 354 patients were included in HRQOL analysis. Mean change in the EQ-5D index was similar in the S-1 and gemcitabine groups within 6 months from treatment initiation (difference, 0.024; P = 0.112), whereas corresponding mean from 12 to 24 months was better in the S-1 group than in the gemcitabine group (difference, 0.071; P < 0.001). Problems in mobility and pain/discomfort were also less frequent in the S-1 group than in the gemcitabine group in that period. Quality-adjusted life months were longer in the S-1 group than in the gemcitabine group (P < 0.001). CONCLUSION: Adjuvant chemotherapy with S-1 does not improve HRQOL within 6 months from treatment initiation but does improve HRQOL thereafter and quality-adjusted life months. CLINICAL TRIAL REGISTRATION NUMBER: UMIN000000655 at UMIN CTR.
• 膵体部の膵神経内分泌腫瘍に合併した膵性胸水の一例

  河野 辰哉; 山雄 健太郎; 中井 敦史; 大本 俊介; 鎌田 研; 三長 孝輔; 宮田 剛; 今井 元; 松本 逸平; 竹山 宜典; 田中 伴典; 筑後 孝章; 林 暁洋; 工藤 正俊

  日本消化器病学会雑誌 (一財)日本消化器病学会 115 (臨増総会) A395 - A395 0446-6586 2018/03
• 膵・胆管合流異常に合併した共通管内乳頭状腫瘍の1例

  幕谷 悠介; 松本 逸平; 大本 俊介; 筑後 孝章; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 中居 卓也; 竹中 完; 工藤 正俊; 竹山 宜典

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 51 (2) 114 - 121 0386-9768 2018/02 [Refereed]
   

  膵・胆管合流異常に合併した共通管内乳頭状腫瘍の1例を報告する.症例は75歳の男性で,6ヵ月間に2度の急性膵炎を発症し保存的加療で軽快した.急性膵炎の原因精査および加療目的で当院へ紹介となった.ERCPでは膵・胆管合流異常を認め,共通管内に7mmの結節様陰影欠損像を認めた.上部内視鏡検査では乳頭部からの粘液排出は認めず,超音波内視鏡検査では共通管内に乳頭状の腫瘍が描出された.造影CTでは膵頭部に拡張した共通管と内部に増強効果を持つ8mmの腫瘤を認めた.尾側の主膵管の拡張は認めなかった.膵・胆管合流異常に合併した共通管内乳頭状腫瘍と診断し,亜全胃温存膵頭十二指腸切除術を施行した.病理肉眼所見では共通管内に発育する有茎性の乳頭状腫瘍で,組織像は管状構造増生を主体とする腺腫であった.免疫組織学的染色ではMUC1,MUC2陰性,MUC5AC陽性で胃型腺腫と最終診断した.(著者抄録)
• Impact of avascular areas, as measured by contrast-enhanced harmonic EUS, on the accuracy of FNA for pancreatic adenocarcinoma.

  Ken Kamata; Mamoru Takenaka; Shunsuke Omoto; Takeshi Miyata; Kosuke Minaga; Kentaro Yamao; Hajime Imai; Toshiharu Sakurai; Naoshi Nishida; Takaaki Chikugo; Yasutaka Chiba; Ippei Matsumoto; Yoshifumi Takeyama; Masatoshi Kudo

  Gastrointestinal endoscopy MOSBY-ELSEVIER 87 (1) 158 - 163 0016-5107 2018/01 [Refereed]
   

  BACKGROUND AND AIMS: EUS-guided FNA (EUS-FNA) is used for the diagnosis of pancreatic adenocarcinoma, but sometimes the method results in a false negative. Occasionally, an avascular area may be observed within the pancreatic adenocarcinoma tumor during contrast-enhanced harmonic EUS (CH-EUS). The aim of this study was to evaluate whether the diagnostic sensitivity of EUS-FNA for pancreatic adenocarcinoma was affected by the presence of avascularity on CH-EUS. METHODS: Two hundred ninety-two patients with pancreatic adenocarcinoma who presented at Kindai University Hospital for EUS-FNA and CH-EUS between June 2009 and August 2013 were retrospectively evaluated. This was a single-center retrospective analysis of prospectively collected data held in a registry. The overall sensitivity of EUS-FNA for the diagnosis of pancreatic adenocarcinoma was calculated. The sensitivities of cytology, histology, and the combination of cytology and histology were also evaluated. These variables were individually evaluated according to the presence or absence of an avascular area on CH-EUS to assess whether the diagnostic sensitivity of EUS-FNA for pancreatic adenocarcinoma was related to the presence of an avascular area within the tumors. RESULTS: The overall sensitivity of EUS-FNA was 90.8% (265/292). The sensitivities of EUS-FNA for lesions with and without an avascular area were 72.9% (35/48) and 94.3% (230/244), respectively, with the difference being statistically significant (P < .001). CONCLUSIONS: EUS-FNA has lower sensitivity for pancreatic adenocarcinoma with avascular areas on CH-EUS.
• Is distal pancreatectomy with en-bloc celiac axis resection effective for patients with locally advanced pancreatic ductal adenocarcinoma? -Multicenter surgical group study.

  Tomohisa Yamamoto; Sohei Satoi; Manabu Kawai; Fuyuhiko Motoi; Masayuki Sho; Ken-Ichiro Uemura; Ippei Matsumoto; Goro Honda; Ken-Ichi Okada; Takahiro Akahori; Hirochika Toyama; Masanao Kurata; Hiroaki Yanagimoto; Hiroki Yamaue; Michiaki Unno; Masanori Kon; Yoshiaki Murakami

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 18 (1) 106 - 113 1424-3903 2018/01 [Refereed]
   

  OBJECTIVES: We retrospectively investigated the operative outcomes of patients who underwent distal pancreatectomy (DP) for invasive pancreatic ductal adenocarcinoma (PDAC) located at the body and tail. METHODS: Data from 395 patients with PDAC who underwent DP with margin-negative resection (R0 or R1) were collected from seven high-volume centers in Japan from 2001 to 2012. Among them, 72 patients underwent DP with en-bloc celiac axis resection (DP-CAR). The remaining 323 patients underwent conventional DP with splenectomy (DP-S). To determine the efficacy of DP-CAR, clinicopathological data were compared between the DP-CAR and the DP-S groups. RESULTS: The DP-S group consisted mainly of patients with resectable disease (93%), and conversely, all patients in the DP-CAR group had borderline resectable or unresectable disease. The overall morbidity was significantly higher in the DP-CAR group than in the DP-S group (63% vs 47%, respectively; P = 0.017). The median survival time (MST) of the DP-CAR group was significantly shorter than that of the DP-S group (17.5 vs 28.6 months, respectively; P = 0.004). However, the MST of patients in the DP-CAR group (n = 61, 85%) who received adjuvant therapy was significantly longer than that of patients in the DP-S group (n = 65, 20%) who underwent R1 resection (21.9 vs 16.7 months, respectively; P = 0.024). CONCLUSION: DP-CAR followed by adjuvant chemotherapy provided an acceptable overall survival rate in patients with highly advanced PDAC, but should be performed with great caution because of high morbidity. Patients with a high risk of positive surgical margins with DP-S may be candidates for DP-CAR.
• Proposed Nomogram Predicting the Individual Risk of Malignancy in the Patients With Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas.

  Jin-Young Jang; Taesung Park; Selyeong Lee; Yongkang Kim; Seung Yeoun Lee; Sun-Whe Kim; Song-Cheol Kim; Ki-Byung Song; Masakazu Yamamoto; Takashi Hatori; Seiko Hirono; Sohei Satoi; Tsutomu Fujii; Satoshi Hirano; Yasushi Hashimoto; Yashuhiro Shimizu; Dong Wook Choi; Seong Ho Choi; Jin Seok Heo; Fuyuhiko Motoi; Ippei Matsumoto; Woo Jung Lee; Chang Moo Kang; Ho-Seong Han; Yoo-Seok Yoon; Masayuki Sho; Hiroaki Nagano; Goro Honda; Sang Geol Kim; Hee Chul Yu; Jun Chul Chung; Yuichi Nagakawa; Hyung Il Seo; Hiroki Yamaue

  Annals of surgery LIPPINCOTT WILLIAMS & WILKINS 266 (6) 1062 - 1068 0003-4932 2017/12 [Refereed]
   

  OBJECTIVES: This study evaluated individual risks of malignancy and proposed a nomogram for predicting malignancy of branch duct type intraductal papillary mucinous neoplasms (BD-IPMNs) using the large database for IPMN. BACKGROUND: Although consensus guidelines list several malignancy predicting factors in patients with BD-IPMN, those variables have different predictability and individual quantitative prediction of malignancy risk is limited. METHODS: Clinicopathological factors predictive of malignancy were retrospectively analyzed in 2525 patients with biopsy proven BD-IPMN at 22 tertiary hospitals in Korea and Japan. The patients with main duct dilatation >10 mm and inaccurate information were excluded. RESULTS: The study cohort consisted of 2258 patients. Malignant IPMNs were defined as those with high grade dysplasia and associated invasive carcinoma. Of 2258 patients, 986 (43.7%) had low, 443 (19.6%) had intermediate, 398 (17.6%) had high grade dysplasia, and 431 (19.1%) had invasive carcinoma. To construct and validate the nomogram, patients were randomly allocated into training and validation sets, with fixed ratios of benign and malignant lesions. Multiple logistic regression analysis resulted in five variables (cyst size, duct dilatation, mural nodule, serum CA19-9, and CEA) being selected to construct the nomogram. In the validation set, this nomogram showed excellent discrimination power through a 1000 times bootstrapped calibration test. CONCLUSION: A nomogram predicting malignancy in patients with BD-IPMN was constructed using a logistic regression model. This nomogram may be useful in identifying patients at risk of malignancy and for selecting optimal treatment methods. The nomogram is freely available at http://statgen.snu.ac.kr/software/nomogramIPMN.
• Reinforced staplers for distal pancreatectomy.

  Manabu Kawai; Seiko Hirono; Ken-Ichi Okada; Sohei Satoi; Hiroaki Yanagimoto; Masanori Kon; Yoshiaki Murakami; Naru Kondo; Masayuki Sho; Takahiro Akahori; Hirochika Toyama; Takumi Fukumoto; Tsutomu Fujii; Ippei Matsumoto; Hidetoshi Eguchi; Hisashi Ikoma; Yutaka Takeda; Jiro Fujimoto; Hiroki Yamaue

  Langenbeck's archives of surgery 402 (8) 1197 - 1204 1435-2443 2017/12 [Refereed]
   

  PURPOSE: The safety and efficacy of reinforced staplers during distal pancreatectomy (DP) remain controversial because of the small sample size. This multicenter single-arm prospective study aims to evaluate the safety and efficacy of reinforced staplers with bioabsorbable material during DP. METHODS: Between October 2014 and August 2015, 121 patients scheduled for DP were enrolled in this study at 11 institutions in Japan. The primary endpoint was the incidence of clinically relevant pancreatic fistula. Protocol treatment was defined as "distal pancreatectomy using reinforced staplers." RESULTS: Per-protocol analysis of 105 patients was performed; 16 of the patients were excluded based on discontinuation of protocol treatment criteria. Clinically relevant pancreatic fistula occurred in 13 (12.4%) of 105 patients. The overall morbidity rate was 29.5% (31 of 105 patients) and severe complication (Clavien classification IIIa or more) was 10.5% (11/105). Mortality rate was 0%, although reoperations were performed on two patients (1.9%). Multivariate logistic regression analysis of independent risk factors for clinically relevant pancreatic fistula after DP using reinforced stapler closure was operative time more than 240 min (P = 0.047, odds ratio 5.79), registration numbers less than 10 (P = 0.046, odds ratio 13.01), and staple line hemorrhage (P = 0.003, odds ratio 16.34). CONCLUSION: This study confirms the safety of reinforced staplers for pancreatic stump closure during DP. However, the efficacy of reinforced staplers for decreasing clinically relevant pancreatic fistula could not be drawn from this study. TRIAL REGISTRATION: This prospective study was registered with ClinicalTrials.gov (NCT02270554) and UMIN Clinical Trial Registry (UMIN000015384).
• S-1単独療法が奏効し組織学的完全奏効が得られた切除不能膵癌の1例

  亀井 敬子; 松本 逸平; 幕谷 悠介; 川口 晃平; 松本 正孝; 村瀬 貴昭; 里井 俊平; 中居 卓也; 鎌田 研; 今井 元; 筑後 孝章; 竹山 宜典

  癌と化学療法 (株)癌と化学療法社 44 (12) 1191 - 1193 0385-0684 2017/11 [Refereed]
   

  症例は67歳、女性。上腸間膜動静脈浸潤および遠隔リンパ節転移を伴う膵頭部癌に対し、S-1による化学療法を施行した。2コース終了後に腫瘍マーカーの正常化、主病変の著明な縮小を認めた。化学療法を継続したが、増悪所見を認めず治療開始から8ヵ月後に亜全胃温存膵頭十二指腸切除術を施行した。切除後の病理診断では、主腫瘍は著明な線維性変化と軽度異型細胞をわずかに認めるのみでリンパ節転移も認めず、組織学的完全奏効と診断した。術後10ヵ月現在、無再発生存中である。(著者抄録)
• Retrospective Study of the Correlation Between Pathological Tumor Size and Survival After Curative Resection of T3 Pancreatic Adenocarcinoma: Proposal for Reclassification of the Tumor Extending Beyond the Pancreas Based on Tumor Size.

  Masanao Kurata; Goro Honda; Yoshiaki Murakami; Kenichiro Uemura; Sohei Satoi; Fuyuhiko Motoi; Masayuki Sho; Ippei Matsumoto; Manabu Kawai; Hiroaki Yanagimoto; Takumi Fukumoto; Minako Nagai; Masahiko Gosho; Michiaki Unno; Hiroki Yamaue

  World journal of surgery SPRINGER 41 (11) 2867 - 2875 0364-2313 2017/11 [Refereed]
   

  BACKGROUND: Even though most patients who undergo resection of pancreatic adenocarcinoma have T3 disease with extra-pancreatic tumor extension, T3 disease is not currently classified by tumor size. The aim of this study was to modify the current TNM classification of pancreatic adenocarcinoma to reflect the influence of tumor size. METHODS: A total of 847 consecutive pancreatectomy patients were recruited from multiple centers. Optimum tumor size cutoff values were calculated by receiver operating characteristics analysis for tumors limited to the pancreas (T1/2) and for T3 tumors. In our modified TNM classification, stage II was divided into stages IIA (T3aN0M0), IIB (T3bN0M0), and IIC (T1-3bN1M0) using tumor size cutoff values. The usefulness of the new classification was compared with that of the current classification using Akaike's information criterion (AIC). RESULTS: The optimum tumor size cutoff value distinguishing T1 and T2 was 2 cm, while T3 was divided into T3a and T3b at a tumor size of 3 cm. The median survival time of the stages IIA, IIB, and IIC were 44.7, 27.6, and 20.3 months, respectively. There were significant differences of survival between stages IIA and IIB (P = 0.02) and between stages IIB and IIC (P = 0.03). The new classification showed better performance compared with the current classification based on the AIC value. CONCLUSIONS: This proposed new TNM classification reflects the influence of tumor size in patients with extra-pancreatic tumor extension (T3 disease), and the classification is useful for predicting mortality.
• [A Case of Conversion Surgery for a Patient with Initially Unresectable Pancreatic Cancer with a Pathological Complete Response to S-1 Chemotherapy].

  Keiko Kamei; Ippei Matsumoto; Yusuke Makutani; Kohei Kawaguchi; Masataka Matsumoto; Takaaki Murase; Shumpei Satoi; Takuya Nakai; Ken Kamata; Hajime Imai; Takaaki Chikugo; Yoshifumi Takeyama

  Gan to kagaku ryoho. Cancer & chemotherapy 44 (12) 1191 - 1193 0385-0684 2017/11 [Refereed]
   

  We present a case ofa 67-year-old woman with Stage IV pancreatic head cancer with invasion to the superior mesenteric vein and artery, and distant lymph node metastases. The patient received S-1 mono-chemotherapy. After 2 courses of chemotherapy, the tumor marker was decreased to the normal levels, and the tumor size was dramatically reduced with undetectable lymph node metastases on CT. As the disease status was maintained following chemotherapy, the patient underwent subtotal stomach preserving pancreaticoduodenectomy, 8 months after initiation of the chemotherapy. Histopathologically, no cancer cells were found in the main tumor and dissected lymph nodes. Final diagnosis was made with pathological complete response. The patient was alive without recurrence for 10 months after surgery.
• 膵疾患における腹腔鏡手術は有用か? 膵良性・低悪性度腫瘍に対する腹腔鏡下尾側膵切除術の有用性に関する検討

  松本 逸平; 亀井 敬子; 竹山 宜典

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 50 (Suppl.2) 158 - 158 0386-9768 2017/10
• 大腸癌肝転移おけるNAC後肝切除症例のTNIを用いた臨床病理学的予後解析による術後化学療法の指針

  中居 卓也; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 松本 逸平; 竹山 宜典

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 50 (Suppl.2) 272 - 272 0386-9768 2017/10
• フライ手術後に一過性可逆性脳症を発症した慢性膵炎急性増悪症例

  里井 俊平; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 松本 逸平; 中居 卓也; 竹山 宜典

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 50 (Suppl.2) 422 - 422 0386-9768 2017/10
• Developing better practices at the institutional level leads to better outcomes after pancreaticoduodenectomy in 3,378 patients: domestic audit of the Japanese Society of Pancreatic Surgery.

  Sohei Satoi; Tomohisa Yamamoto; Hideyuki Yoshitomi; Fuyuhiko Motoi; Manabu Kawai; Tsutomu Fujii; Keita Wada; Hidehito Arimitsu; Masayuki Sho; Ippei Matsumoto; Satoshi Hirano; Hiroaki Yanagimoto; Masayuki Ohtsuka; Michiaki Unno; Hiroki Yamaue; Masanori Kon

  Journal of hepato-biliary-pancreatic sciences WILEY 24 (9) 501 - 510 1868-6974 2017/09 [Refereed]
   

  BACKGROUND: The aim of the present study was to assess recent trends in pancreaticoduodenectomy (PD) and the role of institutional standardization on the development of postoperative complications in 3,378 patients who underwent PD in Japan. METHODS: Data were collected from 3,378 patients who underwent PD in 2006, 2010 and 2014 at 53 institutions. A standardized institution (SI) was defined as one that implements ≥7 of 13 quality initiatives according to departmental policy. There were 1,223 patients in the SI group and 2,155 in the non-SI group. Clinical parameters were compared over time, and between groups. Risk factors for morbidity and mortality were assessed by logistic regression analysis with a mixed-effects model. RESULTS: The number of patients who underwent PD in SIs increased from 16.5% in 2006 to 46.4% in 2014. The SI group experienced an improved process of care and a lower frequency of severe complications vs. the non-SI group (P < 0.001). Multivariate analysis revealed that the SI group was associated with a lower incidence of delayed gastric emptying (odds ratio -0.499, P = 0.008) and incisional surgical site infection (odds ratio -0.999, P < 0.001). CONCLUSION: Standardization of care in PD may be important in reducing post-PD complications, and is a critical element for improving clinical outcomes.
• 膵神経内分泌腫瘍における主膵管浸潤の臨床的意義

  南野 佳英; 松本 逸平; 水本 拓也; 上田 悠貴; 上村 淳; 白川 幸代; 椋棒 英世; 寺井 祥雄; 後藤 直大; 浅利 貞毅; 外山 博近; 岡野 圭一; 味木 徹夫; 福本 巧; 全 陽; 鈴木 康之; 竹山 宜典; 具 英成

  膵臓 (一社)日本膵臓学会 32 (3) 474 - 474 0913-0071 2017/05
• 腹腔鏡下脾動静脈温存脾温存膵体尾部切除術の成績と課題

  後藤 直大; 外山 博近; 浅利 貞毅; 寺井 祥雄; 椋棒 英世; 白川 幸代; 上田 悠貴; 水本 拓也; 南野 佳英; 津川 大介; 小松 昇平; 木下 秘我; 蔵満 薫; 松本 拓; 田中 基文; 木戸 正浩; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 117回 PS - 4 2017/04
• 肥満若年男性から発生した肝細胞腺腫が悪性転化した1例

  幕谷 悠介; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 松本 逸平; 中居 卓也; 竹山 宜典

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 117回 RS - 4 2017/04 [Refereed]
  
• 膵神経内分泌腫瘍における術前主膵管狭窄は予後不良因子である

  南野 佳英; 松本 逸平; 上村 淳; 外山 博近; 浅利 貞毅; 後藤 直大; 寺井 祥雄; 白川 幸代; 水本 拓也; 上田 悠貴; 木下 秘我; 蔵満 薫; 松本 拓; 田中 基文; 木戸 正浩; 味木 徹夫; 岡野 圭一; 鈴木 康之; 竹山 宜典; 福本 巧; 具 英成

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 117回 SF - 3 2017/04 [Refereed]
  
• Pancreatic Duct Involvement in Well-Differentiated Neuroendocrine Tumors is an Independent Poor Prognostic Factor.

  Yoshihide Nanno; Ippei Matsumoto; Yoh Zen; Kyoko Otani; Jun Uemura; Hirochika Toyama; Sadaki Asari; Tadahiro Goto; Tetsuo Ajiki; Keiichi Okano; Yasuyuki Suzuki; Yoshifumi Takeyama; Takumi Fukumoto; Yonson Ku

  Annals of surgical oncology SPRINGER 24 (4) 1127 - 1133 1068-9265 2017/04 [Refereed]
   

  BACKGROUND: The biological behavior of well-differentiated neuroendocrine tumors of the pancreas (PNETs) is difficult to predict. This study was designed to determine whether involvement of the main pancreatic duct (MPD) serves as a poor prognostic factor for PNETs. METHODS: The involvement of the MPD in PNETs was defined as ductal stenosis inside the tumor mass associated with distal MPDs more than twofold larger in diameter than the proximal ducts. We examined the correlation between MPD involvement and other clinicopathological parameters, including nodal metastasis and recurrence-free survival, in 101 patients treated consecutively at three referral centers in Japan. All patients underwent surgical resection. RESULTS: MPD involvement was observed in 13 of the 101 cases (13%) and was associated with multiple unfavorable clinicopathological features (e.g., larger tumor size, higher histological grade, more frequent nodal metastasis, and higher recurrence rates). Patients with MPD involvement also showed significantly worse recurrence-free survival than did those without ductal involvement (P < 0.001), with a 5 years recurrence-free rate of 41%. On multivariate analysis, MPD involvement was significantly associated with nodal metastasis [odds ratio (OR) 16; 95% confidence interval (CI) 3.8-89; P < 0.001] and recurrence (OR 8.0; 95% CI 1.7-46; P = 0.009). The radiology-pathology correlation revealed that stenosis of the MPD was due to periductal and/or intraductal tumor invasion. Cases with MPD involvement had microscopic venous invasion (P = 0.010) and perineural infiltration (P = 0.002) more frequently than did those with no ductal infiltration. CONCLUSIONS: MPD involvement in PNETs may serve as an imaging sign indicating an aggressive clinical course.
• Baseline plasma chromogranin A levels in patients with well-differentiated neuroendocrine tumors of the pancreas: A potential predictor of postoperative recurrence

  Yoshihide Nanno; Hirochika Toyama; Ippei Matsumoto; Kyoko Otani; Sadaki Asari; Tadahiro Goto; Tetsuo Ajiki; Yoh Zen; Takumi Fukumoto; Yonson Ku

  PANCREATOLOGY ELSEVIER SCIENCE BV 17 (2) 291 - 294 1424-3903 2017/03 [Refereed]
   

  Background: The present study aimed to elucidate prognostic values of baseline plasma chromogranin A (CgA) concentrations in patients with resectable, well-differentiated pancreatic neuroendocrine tumors (PNETs). Methods: Preoperative CgA levels in 21 patients with PNET were correlated with clinicopathological factors and patients' survival. Results: Plasma CgA levels ranged 2.9-30.8 pmol/mL (median 6.0), and were significantly elevated in patients with post-operative recurrence (P - 0.004). Using the receiver operating characteristic curve, the optimal cutoff value to predict tumor recurrence was determined as 17.0 pmol/mL. This threshold identified patients with recurrence with 60% sensitivity, 100% specificity, and 90% overall accuracy. Patients with higher CgA levels showed worse recurrence-free survival than those with low CgA levels, both in total (P < 0.001) and in G2 patients (P = 0.020). Conclusions: Combined plasma CgA concentrations and WHO grading may assist in better stratification of PNET patients in terms of the risk of recurrence. (C) 2016 Published by Elsevier B.V. on behalf of IAP and EPC.
• Hemorrhagic and Thromboembolic Complications after Hepato-Biliary-Pancreatic Surgery in Patients Receiving Antithrombotic Therapy.

  Jun Ishida; Takumi Fukumoto; Masahiro Kido; Ippei Matsumoto; Tetsuo Ajiki; Hiroya Kawai; Kenichi Hirata; Yonson Ku

  Digestive surgery KARGER 34 (2) 114 - 124 0253-4886 2017 [Refereed]
   

  BACKGROUND: Perioperative management for patients receiving long-term anticoagulant (AC) and antiplatelet (AP) therapy is a great concern for surgeons. This single-center retrospective study evaluated the risks of hemorrhage and thromboembolism after hepato-biliary-pancreatic (HBP) surgery in such patients. METHODS: Between 2009 and 2014, 886 patients underwent HBP surgery. Patients were categorized into the AC (n = 39), AP (n = 77), or control (n = 770) group according to the administration of antithrombotic drugs. Perioperative management of AC and AP therapies followed the guidelines of the Japanese Circulation Society. The incidences of hemorrhage and thromboembolism were compared among groups. We used 1:1 propensity score matching and compared the incidences between the matched pairs. RESULTS: There were 0, 1 (1.3%), and 26 (3.4%) hemorrhagic complications in the AC, AP, and control groups, respectively (p = 0.16). There were 0, 1 (1.3%), and 6 (0.8%) thromboembolic complications in the AC, AP, and control groups, respectively (p = 0.66). There was no significant difference in hemorrhagic and thromboembolic complications between the propensity-matched pairs. CONCLUSION: The incidences of hemorrhage and thromboembolism after HBP surgery in patients receiving long-term AC and AP therapies are within acceptable ranges.
• Effect of Neoadjuvant Nab-Paclitaxel plus Gemcitabine Therapy on Overall Survival in Patients with Borderline Resectable Pancreatic Cancer: A Prospective Multicenter Phase II Trial (NAC-GA Trial).

  Ken-Ichi Okada; Toshio Shimokawa; Seiko Hirono; Manabu Kawai; Masayuki Sho; Sohei Satoi; Ippei Matsumoto; Hidetoshi Eguchi; Yoshiaki Murakami; Suguru Yamada; Mariko Doi; Hiroki Yamaue

  Oncology 93 (5) 343 - 346 0030-2414 2017 [Refereed]
   

  We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a primary endpoint. The secondary endpoints were recurrence-free survival from the first day of protocol therapy, safety of the protocol therapy (adverse effect), morbidity based on the Clavien Dindo classification of more than III, response rate, preoperative/postoperative tumor marker (CA 19-9, CEA), rate of normalization, reduction rate of the maximum standardized uptake value on positron emission tomography-computed tomography (limited to institutions where positron emission tomography-computed tomography was available), chemotherapeutic effect grade based on Evans' classification, resection rate, R0 resection rate, surgical data (operative time, blood loss, transfusion, postoperative hospital day), overall morbidity rates (reoperation, rate of readmission, mortality), patient rate in postoperative adjuvant therapy (entry rate, completion rate), dose intensity, quality of life regarding fatigue and malaise assessed by the questionnaire of FACIT-F (Japanese version), and peripheral sensory neuropathy assessed by the questionnaire of the FACT/GOG-NTX subscale (version 4; Japanese version). Sixty patients were included in the study, and 18 leading Japanese institutions and hospitals (all high-volume centers in pancreatic surgery) participated in this trial.
• Primary Hepatic Adenosquamous Carcinoma Associated with Primary Sclerosing Cholangitis.

  Kentaro Yamao; Mamoru Takenaka; Hajime Imai; Atsushi Nakai; Shunske Omoto; Ken Kamata; Kosuke Minaga; Takeshi Miyata; Toshiharu Sakurai; Tomohiro Watanabe; Naoshi Nishida; Ippei Matsumoto; Yosihumi Takeyama; Takaaki Chikugo; Masatoshi Kudo

  Oncology S. Karger AG 93 Suppl 1 (1) 76 - 80 0030-2414 2017 [Refereed]
   

  INTRODUCTION: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by multiple fibrotic strictures of the bile duct. More than 40% of deaths in PSC patients are related to malignant tumors, including cholangiocarcinoma. Primary hepatic adenosquamous carcinoma (ASC) is a rare subtype of cholangiocarcinoma containing adenocarcinoma (AC) and squamous cell carcinoma (SCC) components, with a poorer prognosis than other cholangiocarcinomas. We report the first case of a hepatic ASC in a patient with PSC. CASE REPORT: A 28-year-old man was referred for diagnosis and treatment of a liver abscess suspected by contrast-enhanced computed tomography (CE-CT). He had a history of ulcerative colitis and PSC. Abdominal CE-CT revealed a 60-mm-diameter ring-shaped mass with central necrosis in the left lobe. Magnetic resonance imaging demonstrated a poorly circumscribed low-signal-intensity mass in T1-weighted imaging and a high-signal-intensity mass with a scattered low-signal-intensity area in T2-weighted imaging. Abdominal ultrasonography showed a hypoechoic component with a diffuse hyperechoic area in the tumor. Ultrasound-guided biopsy and histological examination showed tumor cells with both squamous and glandular differentiation. Left lobectomy was performed. Microscopic examination revealed 2 components, including moderately differentiated AC and well-differentiated SCC. The final diagnosis was hepatic ASC. CONCLUSION: This is the first reported case of hepatic ASC in a patient with PSC. Patients with PSC should be recognized as being at a risk of not only general cholangiocarcinoma, hepatocellular carcinoma, and metastatic liver tumor, but also ASC.
• Detection of High-Grade Pancreatic Intraepithelial Neoplasia without Morphological Changes of the Main Pancreatic Duct over a Long Period: Importance for Close Follow-Up for Confirmation.

  Kentaro Yamao; Mamoru Takenaka; Atsushi Nakai; Shunske Omoto; Ken Kamata; Kosuke Minaga; Takeshi Miyata; Hajime Imai; Toshiharu Sakurai; Tomohiro Watanabe; Naoshi Nishida; Ippei Matsumoto; Yosihumi Takeyama; Takaaki Chikugo; Masatoshi Kudo

  Oncology S. Karger AG 93 Suppl 1 (1) 81 - 86 0030-2414 2017 [Refereed]
   

  Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural history and time to progression of high-grade PanIN remain unclear. Herein, we report 2 cases of high-grade PanIN without morphological changes of the main pancreatic duct (MPD) over relatively long periods. In the first case, a 63-year-old man was identified with MPD dilation. Magnetic resonance cholangiopancreatography showed localized stenosis in the pancreatic body with distal MPD dilation. Endoscopic retrograde pancreatography (ERP) was attempted because of possible high-grade PanIN but was unsuccessful. At 15-month follow-up, there was no change in the form of the MPD in various images. However, ERP was re-performed because of possible high-grade PanIN, and cytology showed adenocarcinoma. Postoperative pathology indicated diffuse lesions corresponding to high-grade PanINs in the MPD stenosis and surrounding branches. Final diagnosis was high-grade PanIN. In the second case, a 77-year-old man was identified with MPD dilation. Magnetic resonance cholangiography showed localized stenosis in the MPD of the pancreatic head with distal MPD dilation. He was diagnosed with MPD stenosis caused by chronic pancreatitis, and further examination was not recommended. At 25 months, the patient was referred to our hospital because of a mild change in MPD dilation. ERP showed localized irregular stenosis in the MPD, and cytology showed suspected adenocarcinoma. Postoperative pathology indicated a localized lesion with high-grade PanIN in the branch duct around the MPD stenosis. Final diagnosis was high-grade PanIN. In conclusion, we report 2 cases of high-grade PanIN without morphological changes of the MPD over relatively long periods. Even if a definite diagnosis is not obtained at initial examination, a strict follow-up observational study should be performed. Re-examination, including ERP, should also be considered in cases with risk factors of pancreatic cancer, even if there is no change in MPD form.
• Association between the Risk Factors for Pancreatic Ductal Adenocarcinoma and Those for Malignant Intraductal Papillary Mucinous Neoplasm.

  Ken Kamata; Mamoru Takenaka; Atsushi Nakai; Shunsuke Omoto; Takeshi Miyata; Kosuke Minaga; Tomohiro Matsuda; Kentaro Yamao; Hajime Imai; Yasutaka Chiba; Toshiharu Sakurai; Tomohiro Watanabe; Naoshi Nishida; Takaaki Chikugo; Ippei Matsumoto; Yoshifumi Takeyama; Masatoshi Kudo

  Oncology S. Karger AG 93 Suppl 1 (1) 102 - 106 0030-2414 2017 [Refereed]
   

  BACKGROUND AND AIMS: Risk factors for pancreatic ductal adenocarcinoma (PDAC) include diabetes mellitus, chronic pancreatitis, obesity, a family history of pancreatic cancer, and a history of smoking or alcohol consumption. The aim of this study was to evaluate the association between risk factors for PDAC and malignant intraductal papillary mucinous neoplasm (IPMN). METHODS: The study included 134 consecutive patients with IPMN who underwent surgical resection at Kindai University Hospital between April 2009 and March 2015. Data on the presence or absence of mural nodules (MNs) and risk factors for PDAC were evaluated. Multivariable logistic regression analysis was performed with malignant IPMN as the outcome variable and MNs and risk factors for PDAC as explanatory variables. RESULTS: The odds ratio of malignant IPMN to MNs was 3.88 (95% confidence interval [CI] 1.53-9.84; p = 0.004), whereas that of malignant IPMN to smoking history was 1.66 (95% CI 0.74-3.71; p = 0.22). When the presence of MNs was considered as a predictive factor for malignancy, the sensitivity and specificity were 88.5 and 32.1%, respectively, whereas when the presence of both smoking history and MNs was considered, the specificity improved to 73.2%, with a decrease in sensitivity to 42.3%. CONCLUSIONS: The presence of both a smoking history and MNs was a valuable predictive factor for malignant IPMN with high specificity. A smoking history should be considered before surgical resection in addition to the presence of MNs.
• Pancreaticogastrostomy Prevents Postoperative Pancreatic Fistula of Portal Annular Pancreas During Pancreaticoduodenectomy

  Ippei Matsumoto; Keiko Kamei; Shumpei Satoi; Takuya Nakai; Yoshifumi Takeyama

  INTERNATIONAL SURGERY INT COLLEGE OF SURGEONS 101 (11-12) 550 - 553 0020-8868 2016/11 [Refereed]
   

  Portal annular pancreas (PAP) is an asymptomatic congenital pancreatic anomaly in which the uncinate process of the pancreas extends and fuses to the dorsal surface of the body of the pancreas by surrounding the portal vein and or the superior mesenteric vein. During pancreaticoduonectomy (PD), the presence of PAP significantly increased risk for postoperative pancreatic fistula (POPF) because specific management of 2 pancreatic resection planes with 1 or 2 pancreatic ducts is required for pancreatico-intestinal reconstruction. To reduce the risk of POPF, a shift of the resection plain to the left for 1 anastomosis is recommended. We report a case of PAP that was successfully performed PD with pancreaticogastrostomy (PG). PG was conducted with invagination of the 2 resected pancreatic planes together into the stomach to minimize resected volume of the pancreas. A 78-year-old male patient with PAP underwent PD due to a duodenal adenocarcinoma. Intraoperatively, the uncinate process extended extensively behind the portal vein and fused with the dorsal surface of the pancreatic body above the splenic vein. For pancreatico-intestinal reconstruction, PG was performed with invagination of the 2 resected pancreatic planes together into the stomach. The postoperative course was uneventful, and he was discharged on postoperative day 12. Endocrine and exocrine function of the pancreas were maintained well at 10 months after surgery. PG is one of the useful choices for patients with PAP to prevent POPF while maintaining the pancreatic endocrine and exocrine function after PD.
• 膵胆管合流異常症に合併した胆管内乳頭状腫瘍の1例

  幕谷 悠介; 松本 逸平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 中居 卓也; 竹山 宜典

  日本臨床外科学会雑誌 日本臨床外科学会 77 (増刊) 680 - 680 1345-2843 2016/10 [Refereed]
  
• 膵臓 耐容性の低い患者に対する包括的がん治療 多施設共同研究による高齢者膵癌に対する切除意義および予後因子の解析

  庄 雅之; 村上 義昭; 川井 学; 元井 冬彦; 里井 壮平; 松本 逸平; 本田 五郎; 上村 健一郎; 柳本 泰明; 赤堀 宇広; 木下 正一; 長井 美奈子; 西和田 敏; 海野 倫明; 山上 裕機

  日本癌治療学会学術集会抄録集 (一社)日本癌治療学会 54回 WS5 - 1 2016/10 [Refereed]
  
• 十二指腸グラフトが起因した縫合不全の2例

  浅利 貞毅; 外山 博近; 松本 逸平; 新関 亮; 後藤 直大; 寺井 祥雄; 石田 潤; 南野 佳英; 水本 拓也; 上田 悠貴; 味木 徹夫; 木戸 正浩; 福本 巧; 具 英成

  移植 (一社)日本移植学会 51 (総会臨時) 419 - 419 0578-7947 2016/09
• Reappraisal of Total Pancreatectomy in 45 Patients With Pancreatic Ductal Adenocarcinoma in the Modern Era Using Matched-Pairs Analysis: Multicenter Study Group of Pancreatobiliary Surgery in Japan.

  Sohei Satoi; Yoshiaki Murakami; Fuyuhiko Motoi; Masayuki Sho; Ippei Matsumoto; Kenichiro Uemura; Manabu Kawai; Masanao Kurata; Hiroaki Yanagimoto; Tomohisa Yamamoto; Masamichi Mizuma; Michiaki Unno; Shoichi Kinoshita; Takahiro Akahori; Makoto Shinzeki; Takumi Fukumoto; Yasushi Hashimoto; Seiko Hirono; Hiroki Yamaue; Goro Honda; Masanori Kwon

  Pancreas LIPPINCOTT WILLIAMS & WILKINS 45 (7) 1003 - 9 0885-3177 2016/08 [Refereed]
   

  OBJECTIVE: The aim of this study was to reappraise the clinical role of total pancreatectomy with curative intent in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: In 2001 to 2011 database from 7 institutions in Japan, 45 (3.1%) of 1451 patients with PDAC underwent total pancreatectomy (TP group), and 885 patients underwent pancreaticoduodenectomy (PD group). A matched-pairs group consisted of 45 patients matched for age, sex, year, resectability status, and neoadjuvant therapy (matched-PD group). Clinicopathological data, overall survival, and disease-free survival were compared between groups. RESULTS: Clinical features of the TP group revealed higher-stage disease, greater surgical stress, a higher frequency of lymph node metastasis, and a lower adjuvant chemotherapy completion rate compared with the PD group (P < 0.05). Overall survival and disease-free survival in the TP group were significantly worse than those in the PD group (P < 0.05). Multivariate analysis revealed resectability status, neoadjuvant therapy, blood transfusion, lymph node metastasis, and adjuvant therapy to be significant prognostic factors. No differences in mortality and morbidity rates were observed between the 2 groups. A matched-pairs analysis revealed similar surgical outcomes and overall survival. CONCLUSIONS: The surgical outcome of total pancreatectomy for patients with PDAC is acceptable. When margin-negative resection is expected, total pancreatectomy should not be abandoned in the modern era.
• Grade B pancreatic fistulas do not affect survival after pancreatectomy for pancreatic cancer: A multicenter observational study.

  Manabu Kawai; Yoshiaki Murakami; Fuyuhiko Motoi; Masayuki Sho; Sohei Satoi; Ippei Matsumoto; Goro Honda; Seiko Hirono; Ken-Ichi Okada; Michiaki Unno; Yoshiyuki Nakajima; Kenichiro Uemura; A-Hon Kwon; Takumi Fukumoto; Masanao Kurata; Hiroki Yamaue

  Surgery MOSBY-ELSEVIER 160 (2) 293 - 305 0039-6060 2016/08 [Refereed]
   

  BACKGROUND: Several studies have demonstrated that postoperative complications after pancreatectomy for pancreatic cancer adversely affect survival. The impact on survival of a pancreatic fistula according to the classification of the International Study Group for Pancreatic Surgery has not been fully evaluated. The aim of this multicenter, observational study was to evaluate the impact of pancreatic fistula on pancreatic cancer patients who had undergone pancreatectomy. METHODS: Between 2001 and 2012, 1,397 patients who underwent pancreatectomy for pancreatic cancer at 7 high-volume centers in Japan were reviewed retrospectively. The impact of pancreatic fistula on survival was evaluated by univariate and multivariate analysis. RESULTS: Pancreatic fistula occurred in 327 of 1,397 patients (23.4%) and was classified based on the International Study Group for Pancreatic Surgery as follows: grade A in 9.9%, grade B in 10.6%, and grade C in 2.9% of the patients. Median survival time in no fistula/grade A, grade B, and grade C were 23.6, 26.0, and 9.0 months, respectively. There was no significant difference in overall survival between patients with no fistula/grade A and those with grade B (P = .403); in contrast, overall survival in patients with grade C was worse than in patients without grade C (P < .001). The multivariate Cox proportional hazard analysis demonstrated that grade C pancreatic fistula was an independent prognostic factor (hazard ratio 1.59; 95% confidence interval, 1.03-2.45; P = .035). CONCLUSION: Grade B pancreatic fistula after pancreatectomy does not adversely affect long-term survival, but a grade C pancreatic fistula has a negative impact on long-term survival of patients with pancreatic cancer.
• Transpancreatic Mattress Suture with Vicryl Mesh Around the Stump During Distal Pancreatectomy: A Novel Technique for Preventing Postoperative Pancreatic Fistula.

  Ippei Matsumoto; Yoshifumi Takeyama; Keiko Kamei; Shumpei Satoi; Yasuyuki Nakata; Hajime Ishikawa; Takaaki Murase; Masataka Matsumoto; Takuya Nakai

  Journal of the American College of Surgeons ELSEVIER SCIENCE INC 223 (2) e1-5 - E5 1072-7515 2016/08 [Refereed]
  
• Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01).

  Katsuhiko Uesaka; Narikazu Boku; Akira Fukutomi; Yukiyasu Okamura; Masaru Konishi; Ippei Matsumoto; Yuji Kaneoka; Yasuhiro Shimizu; Shoji Nakamori; Hirohiko Sakamoto; Soichiro Morinaga; Osamu Kainuma; Koji Imai; Naohiro Sata; Shoichi Hishinuma; Hitoshi Ojima; Ryuzo Yamaguchi; Satoshi Hirano; Takeshi Sudo; Yasuo Ohashi

  Lancet (London, England) ELSEVIER SCIENCE INC 388 (10041) 248 - 57 0140-6736 2016/07 [Refereed]
   

  BACKGROUND: Although adjuvant chemotherapy with gemcitabine is standard care for resected pancreatic cancer, S-1 has shown non-inferiority to gemcitabine for advanced disease. We aimed to investigate the non-inferiority of S-1 to gemcitabine as adjuvant chemotherapy for pancreatic cancer in terms of overall survival. METHODS: We did a randomised, open-label, multicentre, non-inferiority phase 3 trial undertaken at 33 hospitals in Japan. Patients who had histologically proven invasive ductal carcinoma of the pancreas, pathologically documented stage I-III, and no local residual or microscopic residual tumour, and were aged 20 years or older were eligible. Patients with resected pancreatic cancer were randomly assigned (in a 1:1 ratio) to receive gemcitabine (1000 mg/m(2), intravenously administered on days 1, 8, and 15, every 4 weeks [one cycle], for up to six cycles) or S-1 (40 mg, 50 mg, or 60 mg according to body-surface area, orally administered twice a day for 28 days followed by a 14 day rest, every 6 weeks [one cycle], for up to four cycles) at the data centre by a modified minimisation method, balancing residual tumour status, nodal status, and institutions. The primary outcome was overall survival in the two treatment groups, assessed in the per-protocol population, excluding ineligible patients and those not receiving the allocated treatment. The protocol prespecified that the superiority of S-1 with respect to overall survival was also to be assessed in the per-protocol population by a log-rank test, if the non-inferiority of S-1 was verified. We estimated overall and relapse-free survival using the Kaplan-Meier methods, and assessed non-inferiority of S-1 to gemcitabine using the Cox proportional hazard model. The expected hazard ratio (HR) for mortality was 0.87 with a non-inferiority margin of 1.25 (power 80%; one-sided type I error 2.5%). This trial is registered at UMIN CTR (UMIN000000655). FINDINGS: 385 patients were randomly assigned to treatment between April 11, 2007, and June 29, 2010 (193 to the gemcitabine group and 192 to the S-1 group). Of these, three were exlcuded because of ineligibility and five did not receive chemotherapy. The per-protocol population therefore consisted of 190 patients in the gemcitabine group and 187 patients in the S-1 group. On Sept 15, 2012, following the recommendation from the independent data and safety monitoring committee, this study was discontinued because the prespecified criteria for early discontinuation were met at the interim analysis for efficacy, when all the protocol treatments had been finished. Analysis with the follow-up data on Jan 15, 2016, showed HR of mortality was 0.57 (95% CI 0.44-0.72, pnon-inferiority<0.0001, p<0.0001 for superiority), associated with 5-year overall survival of 24.4% (18.6-30.8) in the gemcitabine group and 44.1% (36.9-51.1) in the S-1 group. Grade 3 or 4 leucopenia, neutropenia, aspartate aminotransferase, and alanine aminotransferase were observed more frequently in the gemcitabine group, whereas stomatitis and diarrhoea were more frequently experienced in the S-1 group. INTERPRETATION: Adjuvant chemotherapy with S-1 can be a new standard care for resected pancreatic cancer in Japanese patients. These results should be assessed in non-Asian patients. FUNDING: Pharma Valley Center, Shizuoka Industrial Foundation, Taiho Pharmaceutical.
• Second primary pancreatic ductal carcinoma in the remnant pancreas after pancreatectomy for pancreatic ductal carcinoma: High cumulative incidence rates at 5 years after pancreatectomy

  Jun Ishida; Hirochika Toyama; Ippei Matsumoto; Sadaki Asari; Tadahiro Goto; Sachio Terai; Yoshihide Nanno; Azusa Yamashita; Takuya Mizumoto; Yuki Ueda; Masahiro Kido; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  PANCREATOLOGY ELSEVIER SCIENCE BV 16 (4) 615 - 620 1424-3903 2016/07 [Refereed]
   

  Objectives: The aim of this study was to determine the incidence rate and clinical features of second primary pancreatic ductal carcinoma (SPPDC) in the remnant pancreas after pancreatectomy for pancreatic ductal carcinoma (PDC). Methods: Data of patients undergoing R0 resection for PDC at a single high-volume center were reviewed. SPPDC was defined as a tumor in the remnant pancreas after RO resection for PDC, and SPPDC met at least one of the following conditions: 1) the time interval between initial pancreatectomy and development of a new tumor was 3 years or more; 2) the new tumor was not located in contact with the pancreatic stump. We investigated the clinical features and treatment outcomes of patients with SPPDC. Results: This study included 130 patients who underwent surgical resection for PDC between 2005 and 2014. Six (4.6%) patients developed SPPDC. The cumulative 3- and 5-year incidence rates were 3.1% and 17.7%, respectively. Four patients underwent remnant pancreatectomy for SPPDC. They were diagnosed with the disease in stage IIA or higher and developed recurrence within 6 months after remnant pancreatectomy. One patient received carbon ion radiotherapy and survived 45 months. One patient refused treatment and died 19 months after the diagnosis of SPPDC. Conclusions: The incidence rate of SPPDC is not negligible, and the cumulative 5-year incidence rate of SPPDC is markedly high. Post-operative surveillance of the remnant pancreas is critical for the early detection of SPPDC, even in long-term survivors after PDC resection. (C) 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved.
• 膵仮性嚢胞内出血を繰り返す血友病B併存患者に対し、安全に脾合併尾側膵切除と周術期管理を施行し得た1例

  村瀬 貴昭; 石川 原; 松本 正孝; 中多 靖幸; 亀井 敬子; 里井 俊平; 松本 逸平; 中居 卓也; 法里 慧; 井上 宏昭; 中尾 慎一; 竹山 宜典

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 28回 555 - 555 2016/06
• Preoperative independent prognostic factors in patients with borderline resectable pancreatic ductal adenocarcinoma following curative resection: the neutrophil-lymphocyte and platelet-lymphocyte ratios.

  Sadaki Asari; Ippei Matsumoto; Hirochika Toyama; Makoto Shinzeki; Tadahiro Goto; Jun Ishida; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Surgery today SPRINGER 46 (5) 583 - 92 0941-1291 2016/05 [Refereed]
   

  PURPOSE: The therapeutic strategy for borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC) has remained unestablished because the preoperative prognostic factors have not been determined. METHODS: One hundred eighty-four consecutive PDAC patients who underwent upfront surgery with a curative resection between January 2000 and June 2013 at Kobe University Hospital were retrospectively studied. The PDAC patients were stratified into resectable (R)-PDAC (n = 147) and BR-PDAC patients (n = 37). We evaluated the independent prognostic significance of the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) in the BR-PDAC patients. RESULTS: BR-PDAC patient survival was significantly worse than R-PDAC patient survival (median survival time: 22.1 months vs. 24.3 months; 5-year survival rate 6 vs. 21 %; P = 0.042). The median survival in BR-PDAC patients with a preoperative NLR of >3 (n = 12) was 10.2 months, while that in patients with preoperative NLR of ≤3 (n = 25) was 24.9 months (P = 0.002). Moreover, the median survival in BR-PDAC patients with a preoperative PLR of >225 (n = 8) was 10.2 months, while that in patients with a preoperative PLR of ≤225 (n = 29) was 24.7 months (P = 0.003). Preoperative NLR >3 (HR = 2.980, 95 % CI 1.251-6.920; P = 0.015) and PLR >225 (HR = 3.050, 95 % CI 1.169-7.468; P = 0.024) were independent prognostic factors in BR-PDAC patients. CONCLUSIONS: Higher preoperative NLR and PLR can be independent predictive risk factors in BR-PDAC patients following curative resection.
• A Novel Technique for the Intraoperative Identification of Biliary Drainage Areas in the Liver after Hepatobiliary Resection for Perihilar Cholangiocarcinoma.

  Takumi Fukumoto; Takeshi Urade; Masahiro Kido; Atsushi Takebe; Tetsuo Ajiki; Hirochika Toyama; Ippei Matsumoto; Yonson Ku

  Journal of the American College of Surgeons ELSEVIER SCIENCE INC 222 (5) e31-8 - E38 1072-7515 2016/05 [Refereed]
  
• Recommendation of treatment strategy for postpancreatectomy hemorrhage: Lessons from a single-center experience in 35 patients

  Sadaki Asari; Ippei Matsumoto; Hirochika Toyama; Masato Yamaguchi; Takuya Okada; Makoto Shinzeki; Tadahiro Goto; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  PANCREATOLOGY ELSEVIER SCIENCE BV 16 (3) 454 - 463 1424-3903 2016/05 [Refereed]
   

  Background: Postpancreatectomy hemorrhage (PPH) is a life-threatening complication of pancreatic surgery. The shift from surgical to radiological intervention was recently reported in retrospective cohort studies, but it has remained controversial as to which emergent intervention provides optimal management. Methods: All 553 patients who underwent standard pancreatic resection at Kobe University Hospital between January 2003 and December 2013 were included. Patient data and complication data were identified from a prospective database. Results: The overall incidence of PPH was 6% (35 of 553 patients). Ten patients underwent endoscopic intervention or observation monitoring, or suffered hemorrhagic sudden death. Among the remaining 25 PPH patients, primary surgical intervention was successful in the 6 hemodynamically unstable PPH patients. Primary radiological intervention could successfully stop the bleeding in 15 of the 17 patients with late-PPH. Nine patients who had bleeding from the hepatic artery after pancreaticoduodenectomy were rescued by endovascular embolization of the artery-trunk. The in-hospital mortality of PPH was 20% (7 of 35). Four of the 5 PPH patients who died following any intervention eventually died due to the other complications associated with prolonged pancreatic fistula. Conclusions: The leading treatment has been radiological intervention. Endovascular embolization of the hepatic artery-trunk can be securely performed only if blood flow to the liver by an alternate route is confirmed. To reduce mortality of PPH patients, it is necessary to prevent other complications associated with pancreatic fistula following hemostasis. Proactive surgical intervention such as abscess drainage or remnant pancreatectomy is a key consideration. (C) 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved.
• 局所進行膵癌に対する粒子線治療を用いた治療戦略

  後藤 直大; 外山 博近; 浅利 貞毅; 寺井 祥雄; 水本 拓也; 山下 亜津紗; 南野 佳英; 石田 潤; 木下 秘我; 蔵満 薫; 松本 拓; 田中 基文; 武部 敦志; 木戸 正浩; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 116回 PS - 1 2016/04
• 80歳以上高齢者膵癌に対する外科治療成績 多施設共同研究

  庄 雅之; 村上 義昭; 川井 学; 元井 冬彦; 里井 壮平; 松本 逸平; 本田 五郎; 上村 健一郎; 柳本 泰明; 倉田 昌直; 赤堀 宇広; 木下 正一; 長井 美奈子; 西和田 敏; 海野 倫明; 山上 裕機; 中島 祥介

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 116回 OP - 6 2016/04 [Refereed]
  
• Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study.

  Masayuki Sho; Yoshiaki Murakami; Manabu Kawai; Fuyuhiko Motoi; Sohei Satoi; Ippei Matsumoto; Goro Honda; Kenichiro Uemura; Hiroaki Yanagimoto; Masanao Kurata; Takahiro Akahori; Shoichi Kinoshita; Minako Nagai; Satoshi Nishiwada; Takumi Fukumoto; Michiaki Unno; Hiroki Yamaue; Yoshiyuki Nakajima

  Journal of hepato-biliary-pancreatic sciences SPRINGER JAPAN KK 23 (3) 188 - 97 1868-6974 2016/03 [Refereed]
   

  BACKGROUND: The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older. METHODS: A retrospective multicenter analysis of 1401 patients who had undergone pancreatic resection for pancreatic cancer was performed. The patients aged ≥ 80 years (n = 99) were compared with a control group <80 years of age (n = 1302). RESULTS: There were no significant differences in the postoperative complications and mortality between the two groups. However, the prognosis of octogenarians was poorer than that of younger patients for both resectable and borderline resectable tumors. Importantly, there were few long-term survivors in the elderly group, especially among those with borderline resectable pancreatic cancer. A multivariate analysis of the prognostic factors in the very elderly patients indicated that the completion of adjuvant chemotherapy was the only significant factor. In addition, preoperative albumin level was the only independent risk factor for a failure to complete adjuvant chemotherapy. CONCLUSION: This study demonstrates that the postoperative prognosis in octogenarian patients was not good as that in younger patients possibly due to less frequent completion of adjuvant chemotherapy.
• Anatomical variations of liver blood supply in patients with pancreaticobiliary maljunction.

  Kenta Shinozaki; Tetsuo Ajiki; Taku Matsumoto; Yuko Yoshida; Sae Murakami; Taro Okazaki; Hirochika Toyama; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  Surgery today SPRINGER 46 (2) 169 - 75 0941-1291 2016/02 [Refereed]
   

  PURPOSE: Pancreaticobiliary maljunction (PBM) arises from a developmental abnormality during the embryonic period; thus, these patients may have anatomical variations of the liver blood supply, including aberrant vessels and unusual locations. METHODS: We reviewed retrospectively the vascular anatomy of 52 patients with PBM, who were seen between 1998 and 2013. RESULTS: There were 11 male patients and 41 female patients. Sixteen patients had bile duct type (C-P type) PBM, 35 had pancreatic duct type (P-C type) PBM, and one had complex type PBM. Thirty-three patients had biliary dilatation. Nine (17.3 %) patients had an aberrant (replaced or accessory) hepatic artery and 2 (3.8 %) had an aberrant portal vein. Among 39 patients evaluated by contrast-enhanced computed tomography, 8 (20.5 %) had their right hepatic artery positioned on the ventral side of the common bile duct. The presence of aberrant hepatic vessels was not related to the type of confluence, biliary dilatation, type of Todani classification, or associated biliary malignancies. CONCLUSIONS: The incidence of the right hepatic artery being located on the ventral side of the common bile duct may be higher in patients with PBM than the naturally occurring incidence of about 10 % in the general Japanese population.
• Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of pancreatic cysts.

  Ken Kamata; Masayuki Kitano; Shunsuke Omoto; Kumpei Kadosaka; Takeshi Miyata; Kentaro Yamao; Hajime Imai; Hiroki Sakamoto; Yogesh Harwani; Takaaki Chikugo; Yasutaka Chiba; Ippei Matsumoto; Yoshifumi Takeyama; Masatoshi Kudo

  Endoscopy GEORG THIEME VERLAG KG 48 (1) 35 - 41 0013-726X 2016/01 [Refereed]
   

  BACKGROUND AND STUDY AIM: Comparison of fundamental B-mode endoscopic ultrasonography (FB-EUS) and contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) in the differential diagnosis of pancreatic cysts according to presence of mural nodules. PATIENTS AND METHODS: Between April 2007 and April 2012, FB-EUS and CH-EUS data were prospectively collected from 581 consecutive patients with pancreatic cysts, and were retrospectively analyzed from 70 with subsequent cyst resection. Presence and height of mural nodules as detected on FB-EUS and CH-EUS were evaluated, and thence accuracies of both methods for diagnosing mucinous versus nonmucinous and malignant versus benign cysts. RESULTS: On pathological examination 48 cysts were mucinous and 22 were nonmucinous; 30 cysts were malignant (high grade dysplasia or invasive carcinoma) and 40 were benign. If presence of a mural nodule was considered to indicate a mucinous cyst, FB-EUS and CH-EUS accuracies did not differ significantly (respectively: sensitivity 85 % vs. 79 %; specificity 46 % vs. 96 %; accuracy 73 % vs. 84 %, P = 0.057). If presence of mural nodule was considered to indicate malignancy, CH-EUS was significantly more accurate than FB-EUS (respectively: sensitivity 97 % vs. 97 %; specificity 75 % vs. 40 %; accuracy 84 % vs. 64 %, P = 0.0001). For diagnosing malignancy by evaluating mural nodule height, the area under the receiver operating characteristic (AUROC) was 0.84 and 0.93 for FB-EUS and CH-EUS, respectively (P = 0.028). Presence of a mural nodule of height ≥ 4 mm on CH-EUS was a sign of malignancy (false-positive fraction 0.2; true-positive fraction 0.93; odds ratio 56.0). CONCLUSIONS: CH-EUS is more accurate than FB-EUS for diagnosing malignant pancreatic cysts.
• 腹腔鏡下膵切除術 安全な術式の定型化を目指して 腹腔鏡下尾側膵切除術の安全な術式の定型化

  後藤 直大; 外山 博近; 浅利 貞毅; 寺井 祥雄; 石田 潤; 木下 秘我; 蔵満 薫; 松本 拓; 田中 基文; 武部 敦志; 木戸 正浩; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 20 (7) SY27 - 7 1344-6703 2015/12
• Acute graft-versus-host disease following simultaneous pancreas-kidney transplantation: report of a case.

  Sadaki Asari; Ippei Matsumoto; Hirochika Toyama; Makoto Shinzeki; Tadahiro Goto; Masaki Tanaka; Sachiyo Shirakawa; Hironori Yamashita; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Surgery today SPRINGER 45 (12) 1567 - 71 0941-1291 2015/12 [Refereed]
   

  Acute graft-versus-host-disease (aGVHD) is a rare complication in the setting of pancreas-kidney transplantation (PKT). We herein describe the case of a 37-year-old male with severe type 1 diabetes with chronic renal failure who received simultaneous PKT from a female donor. Diarrhea developed on postoperative day (POD) 10. Subsequently, fever and liver dysfunction occurred on POD 32. Skin rashes appeared with pain and itching on his trunk and extremities on POD 40. As pancytopenia occurred on POD 63, bone marrow biopsies demonstrated profound hypoplastic marrow. On POD 69, we eventually made a definitive diagnosis of aGVHD because skin biopsies revealed the XX chromosome signal in a fluorescence in situ hybridization analysis. Thereafter, 100 mg of prednisolone was administered for 5 days. Although every symptom was temporarily improved, on POD 156, the patient expired from the septic pneumonia without any effects of antibiotics. Clinician should be aware that PKT has the potential to induce aGVHD.
• Impact of Preoperative Biliary Drainage on Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma: A Multicenter Observational Study.

  Kenichiro Uemura; Yoshiaki Murakami; Sohei Satoi; Masayuki Sho; Fuyuhiko Motoi; Manabu Kawai; Ippei Matsumoto; Goro Honda; Masanao Kurata; Hiroaki Yanagimoto; Satoshi Nishiwada; Takumi Fukumoto; Michiakil Unno; Hiroki Yamaue

  Annals of surgical oncology SPRINGER 22 Suppl 3 S1238-46 - S1246 1068-9265 2015/12 [Refereed]
   

  BACKGROUND: This study aimed to evaluate the impact of preoperative biliary drainage (PBD) on the long-term survival of patients with pancreatic ductal adenocarcinoma (PDAC) who underwent pancreaticoduodenectomy (PD). METHODS: A multicenter observational study was performed using a common database of patients with resected PDAC from seven high-volume surgical institutions in Japan. RESULTS: Of 932 patients who underwent PD for PDAC, 573 (62 %) underwent PBD, including 407 (44 %) who underwent endoscopic biliary drainage (EBD) and 166 (18 %) who underwent percutaneous transhepatic biliary drainage (PTBD). The patients who did not undergo PBD and those who underwent EBD had a significantly better overall survival than those who underwent PTBD, with median survival times of 25.7 months (P < 0.001), 22.3 months (P = 0.001), and 16.7 months, respectively. Multivariate analysis showed that seven clinicopathologic factors, including the use of PTBD but not EBD, were independently associated with poorer overall survival. Furthermore, patients who underwent PTBD more frequently experienced peritoneal recurrence (23 %) than those who underwent EBD (10 %; P < 0.001) and those who did not undergo PBD (11 %; P = 0.001). Multivariate analysis demonstrated that the independent risk factors for peritoneal recurrence included surgical margin status (P < 0.001) and use of PTBD (P = 0.004). CONCLUSIONS: Use of PTBD, but not EBD, was associated with a poorer prognosis, with an increased rate of peritoneal recurrence among patients who underwent PD for PDAC.
• Proposed preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after surgical resection: A multi-center retrospective study

  Ippei Matsumoto; Yoshiaki Murakami; Makoto Shinzeki; Sadaki Asari; Tadahiro Goto; Masaji Tani; Fuyuhiko Motoi; Kenichiro Uemura; Masayuki Sho; Sohei Satoi; Goro Honda; Hiroki Yamaue; Michiaki Unno; Takahiro Akahori; A-Hon Kwon; Masanao Kurata; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  PANCREATOLOGY KARGER 15 (6) 674 - 680 1424-3903 2015/11 [Refereed]
   

  Background/objective: Although surgical resection remains the only chance for cure in patients with pancreatic ductal adenocarcinoma (PDAC), postoperative early recurrence (ER) is frequently encountered. The purpose of this study is to determine the preoperative predictive factors for ER after upfront surgical resection. Methods: Between 2001 and 2012, 968 patients who underwent upfront surgery with R0 or R1 resection for PDAC at seven high-volume centers in Japan were retrospectively reviewed. ER was defined as relapse within 6 months after surgery. Study analysis stratified by resectable (R) and borderline resectable (BR) PDACs was conducted according to the National Comprehensive Cancer Network guidelines. Results: ER occurred in 239 patients (25%) with a median survival time (MST) of 8.8 months. Modified Glasgow prognostic score = 2 (odds ratio (OR) 2.06, 95% confidence interval (CI) 1.05-3.95; P = 0.044), preoperative CA19-9 >= 300 U/ml (OR 1.94, 1.29-2.90; P = 0.003), and tumor size >= 30 mm (OR 1.72, 1.16 -2.56; P = 0.006), were identified as preoperative independent predictive risk factors for ER in patients with R-PDAC. In the R-PDAC patients, MST was 35.5, 263, and 15.9 months in patients with 0, 1 and >= 2 risk factors, respectively. There were significant differences in overall survival between the three groups (P < 0.001). No preoperative risk factors were identified in BR-PDAC patients with a high rate of ER (39%). Conclusions: There is a high-risk subset for ER even in patients with R-PDAC and a simple risk scoring system is useful for prediction of ER. Copyright (C) 2015, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
• [A Case of Invasive Intraductal Papillary Mucinous Carcinoma, Penetrating the Stomach, Colon, and Jejunum].

  Tadahiro Goto; Hirochika Toyama; Sadaki Asari; Sachio Terai; Hisoka Kinoshita; Taku Matsumoto; Kaori Kuramitsu; Motofumi Tanaka; Atsushi Takebe; Masahiro Kido; Ippei Matsumoto; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 42 (12) 2391 - 3 0385-0684 2015/11 [Refereed]
   

  A 69-year-old woman was admitted to a nearby clinic complaining of abdominal pain. Abdominal CT showed a 10 cm diameter huge cystic lesion in the body and tail of the pancreas. The patient was referred to our institution for treatment. Endoscopic ultrasonography (EUS) revealed a cystic mass with a solid lesion. Endoscopic retrograde pancreatography(ERP) demonstrated mucous at the opening of the papilla of Vater and dilatation of the pancreatic duct with a solid nodule. Contrast radiography revealed a fistula from the tumor to the jejunum. A biopsy specimen from the lesion showed adenocarcinoma. Intraoperative findings showed a tumor occupying the pancreas body and tail with suspected invasion to the stomach, jejunum, and transverse colon. We performed distal pancreatectomy with partial resection of stomach, jejunum, and colon. Pathological findings showed an invasive type of IPMC, with invasion to the subserosal layer of the stomach and colon and the mucous layer of the jejunum. While IPMC is recognized as a slow growing malignancy, some cases of invasive carcinoma with fistulation into adjacent organs have been reported. To our knowledge, a case of IPMC penetrating to 3 adjacent organs is rare.
• 大動脈周囲リンパ節転移陽性膵癌の治療成績 多施設共同研究解析結果

  庄 雅之; 村上 義昭; 元井 冬彦; 里井 壮平; 松本 逸平; 川井 学; 本田 五郎; 上村 健一郎; 柳本 泰明; 倉田 昌直; 後藤 直大; 赤堀 宇広; 海野 倫明; 山上 裕機; 中島 祥介

  日本臨床外科学会雑誌 日本臨床外科学会 76 (増刊) 725 - 725 1345-2843 2015/10 [Refereed]
  
• [A case of epidermoid cyst in an intrapancreatic accessory spleen showing cyst-in-cyst-like structure mimicking mucinous cystic neoplasm].

  Yuichi Hirata; Yoshifumi Arisaka; Hiromu Kutsumi; Arata Sakai; Mamoru Takenaka; Hideyuki Shiomi; Takeshi Azuma; Ippei Matsumoto; Shigeo Hara; Shujiro Yazumi

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology Japanese Society of Gastroenterology 112 (10) 1858 - 67 0446-6586 2015/10 [Refereed]
   

  In 2010, a 39-year-old woman presented with a cystic lesion, 16 mm in diameter, in the tail of the pancreas. Regular follow-ups were conducted to monitor this lesion; its diameter was found to increase to 45 mm in 2013. Thus, the patient was admitted to our hospital for further examination and treatment. Abdominal US, abdominal contrast-enhanced CT, and MRI showed a cystic lesion of 45 mm in diameter in the tail of the pancreas, which had internal septae and mural nodules inside. EUS revealed a cyst-in-cyst-like structure, with a thickened cystic wall along the entire circumference. Thus, distal pancreatectomy and splenectomy were performed on the basis of a diagnosis of mucinous cystic neoplasm. Histopathological examination of a resected specimen showed that the lesion comprised a substantial component of red-brown tone, with adjacent cystic components. The final diagnosis was an epidermoid cyst in an intrapancreatic accessory spleen.
• National Comprehensive Cancer Network Resectability Status for Pancreatic Carcinoma Predicts Overall Survival.

  Yoshiaki Murakami; Sohei Satoi; Masayuki Sho; Fuyuhiko Motoi; Ippei Matsumoto; Manabu Kawai; Goro Honda; Kenichiro Uemura; Hiroaki Yanagimoto; Makoto Shinzeki; Masanao Kurata; Shoichi Kinoshita; Hiroki Yamaue; Michiaki Unno

  World journal of surgery SPRINGER 39 (9) 2306 - 14 0364-2313 2015/09 [Refereed]
   

  BACKGROUND: The aim of this study was to evaluate the validity of preoperative resectability status, as defined by the National Comprehensive Cancer Network (NCCN), from the viewpoint of overall survival. METHODS: A total of consecutive 704 patients with pancreatic head carcinoma who underwent pancreatoduodenectomy with upfront surgery at seven Japanese hospitals between 2001 and 2012 were evaluated retrospectively. According to the NCCN definition of preoperative resectability status, tumors were divided into resectable tumors without vascular contact (R group), resectable tumors with portal or superior mesenteric vein (PV/SMV) contact of ≦180° (R-PV group), borderline resectable(BR) tumors with PV/SMV contact of >180° (BR-PV group), and BR tumors with arterial contact (BR-A group). The relationship between the NCCN definition of preoperative resectability status and overall survival was analyzed. RESULTS: Of the 704 patients, 389, 114, 145, and 56 were classified into the R group, the R-PV group, the BR-PV group, and the BR-A group, respectively. Overall survival of the BR-PV and BR-A groups was significantly worse than that of the R group and R-PV groups (P < 0.05), although there was no significant difference in overall survival between the R group and the R-PV group (P = 0.310). Multivariate analysis revealed that PV/SMV contact of >180° (P = 0.008) and arterial contact (P < 0.001) were independent prognostic factors of overall survival. CONCLUSION: From the viewpoint of overall survival, the NCCN definition of preoperative resectability status was valid.
• [Successful Multimodal Treatment for Aggressive Extrahepatic Metastatic Hepatocellular Carcinoma - A Case Report].

  Hidetoshi Gon; Masahiro Kido; Takumi Fukumoto; Atsushi Takebe; Motofumi Tanaka; Kaori Kuramitsu; Hisoka Kinoshita; Kenji Fukushima; Takeshi Urade; Shinichi So; Makoto Shinzeki; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 42 (9) 1111 - 4 0385-0684 2015/09 [Refereed]
   

  A 38-year-old man underwent right hepatectomy for a huge hepatocellular carcinoma(HCC)in the right hepatic lobe. Four months later, recurrent and metastatic disease were observed in the remnant liver and right lung, respectively. We performed a hepatectomy for the recurrent lesion because transcatheter arterial chemoembolization (TACE) was not effective. After surgery, we initiated sorafenib treatment for the lung metastases. One year later, the lung metastases worsened and metastases were observed in the mediastinal lymph nodes, and both metastatic lesions were resected. Seven months later, para-aortic lymph nodal metastasis was observed and dissected. Three months later, metastasis to the supraclavicular lymph node was observed. We performed particle radiation therapy and a complete response was achieved. One year later, metastases in both lungs were observed and resected. Despite continued sorafenib administration throughout the clinical course, a metastasis to the left adrenal gland was observed. This lesion was extirpated because no other recurrent lesions were detected. At 4 years and 6 months after the first operation, no other recurrences have occurred. Currently, sorafenib is the initial drug of choice for HCC with extrahepatic metastases. It is possible to improve the prognosis of patients with HCC and extrahepatic metastases by applying surgical treatment during the course of sorafenib administration.
• Postoperative Serum Albumin Level is a Marker of Incomplete Adjuvant Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.

  Ippei Matsumoto; Masaki Tanaka; Sachiyo Shirakawa; Makoto Shinzeki; Hirochika Toyama; Sadaki Asari; Tadahiro Goto; Hironori Yamashita; Jun Ishida; Tetsuo Ajiki; Takumi Fukumoto; Mototsugu Shimokawa; Yonson Ku

  Annals of surgical oncology SPRINGER 22 (7) 2408 - 15 1068-9265 2015/07 [Refereed]
   

  BACKGROUND: Adjuvant chemotherapy (AC) is recommended as a standard treatment after curative resection in patients with pancreatic adenocarcinoma (PA). Although patients who failed to complete AC had significantly worse survival compared with those who completed AC for cancers in various organs, the effects of complete AC on survival in patients with PA have not been investigated. The purpose of this study was to clarify the impact of complete AC on PA patient survival and to identify independent risk factors for incomplete AC. METHODS: Medical records of 236 consecutive PA patients who planned to undergo surgical resection with curative intent between January 2000 and September 2012 at Kobe University Hospital were retrospectively reviewed. Of these, the complete AC (n = 75) and the incomplete AC (n = 30) groups due to adverse events were compared. RESULTS: Patient survival was significantly better in the complete AC group than in the incomplete AC group (median survival time 48.9 vs. 17.9 months; 5-year survival rate 42.7 vs. 17.1 %; p < 0.0001). Preoperative white blood cell count and postoperative serum albumin level were identified as independent risk factors for incomplete AC. By receiver operating characteristic curve analysis, the cutoff value of postoperative serum albumin level was 3.1 mg/dL. CONCLUSIONS: PA patients who completed AC had significantly better survival than those who failed to complete AC. Postoperative serum albumin level is a marker for failure to complete AC. Further prospective studies are needed to determine whether perioperative nutritional intervention could increase AC completion rate and improve prognosis in PA patients.
• Portal or superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head carcinoma

  Murakami, Y; Satoi, S; Motoi, F; Sho, M; Kawai, M; Matsumoto, I; Honda, G

  BRITISH JOURNAL OF SURGERY WILEY-BLACKWELL 102 (7) 837 - 846 0007-1323 2015/06 [Refereed]
   

  BackgroundThe aim of this study was to determine the added value of portal or superior mesenteric vein (PV/SMV) resection during pancreatoduodenectomy for pancreatic head carcinoma. MethodsA multicentre observational study was conducted in patients with p
• Postoperative prognosis of pancreatic cancer with para-aortic lymph node metastasis: a multicenter study on 822 patients.

  Masayuki Sho; Yoshiaki Murakami; Fuyuhiko Motoi; Sohei Satoi; Ippei Matsumoto; Manabu Kawai; Goro Honda; Kenichiro Uemura; Hiroaki Yanagimoto; Masanao Kurata; Takumi Fukumoto; Takahiro Akahori; Shoichi Kinoshita; Minako Nagai; Satoshi Nishiwada; Michiaki Unno; Hiroki Yamaue; Yoshiyuki Nakajima

  Journal of gastroenterology SPRINGER JAPAN KK 50 (6) 694 - 702 0944-1174 2015/06 [Refereed]
   

  BACKGROUND: The prognosis of pancreatic cancer patients with metastatic para-aortic lymph node (PALN) has been reported to be extremely poor. In general, PALN metastasis has been considered as a contraindication for pancreatic resection. The aim of this study was to reevaluate the postoperative prognostic value of PALN metastasis in pancreatic cancer and to determine the validity of pancreatic surgery. METHODS: Retrospective multicenter analysis of 882 patients who have undergone curative-intent pancreatic resection with pathological evaluation of PALNs for pancreatic ductal adenocarcinoma between 2001 and 2012 was conducted. Clinicopathological data and outcomes were evaluated with univariate and multivariate analysis. RESULTS: In total, 102 (12.4 %) patients had positive metastasis in PALN. Patients with metastatic PALN had significantly poorer survival than those without (17 vs. 23 months; p < 0.001). Multivariable analysis of 822 patients identified adjuvant chemotherapy, primary tumor status, regional lymph node metastasis, portal vein invasion, pre- and post-operative serum CA19-9 levels, and tumor grade as independent prognostic factors. In contrast, PALN metastasis did not have a significant prognostic value. Furthermore, the multivariate prognostic analysis in patients with PALN metastasis revealed that adjuvant chemotherapy and the number of metastatic PALN were significantly associated with long-term survival. Lung metastasis as initial recurrence was observed more often in patients with PALN metastasis in comparison with those without. CONCLUSIONS: Some pancreatic cancer patients with metastatic PALN may survive for longer than expected after pancreatectomy. Adjuvant chemotherapy and the number of metastatic PALN were critical factors for long-term survival of those patients.
• 切除可能膵癌に対する治療戦略 手術先行vs術前治療 肝胆膵 切除可能膵癌に対する治療戦略

  後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 村上 義昭; 川井 学; 元井 冬彦; 上村 健一郎; 庄 雅之; 里井 壯平; 本田 五郎; 山上 裕機; 海野 倫明; 赤堀 宇広; 權 雅憲; 倉田 昌直; 福本 巧; 具 英成

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 115回 PD - 7 2015/04
• 肝胆膵 切除可能膵癌の術前療法臨床試験における術前切除可能性判定標準化の重要性

  村上 義昭; 里井 壯平; 元井 冬彦; 川井 学; 本田 五郎; 庄 雅之; 松本 逸平; 上村 健一郎; 倉田 昌直; 赤堀 宇弘; 柳本 泰明; 浅利 貞毅; 海野 倫明; 山上 裕機

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 115回 OP - 1 2015/04 [Refereed]
  
• 肝胆膵 膵管内腺癌患者の長期生存率に対する術前胆道ドレナージの効果に関する多施設共同観察研究(A multicenter observational study of potential effect of preoperative biliary drainage on long-term survival in the patients with pancreatic ductal adenocarcinoma)

  上村 健一郎; 村上 義昭; 里井 壮平; 庄 雅之; 元井 冬彦; 川井 学; 松本 逸平; 本田 五郎; 倉田 昌直; 柳本 泰明; 赤堀 宇広; 浅利 貞毅; 海野 倫明; 山上 裕機

  日本外科学会定期学術集会抄録集 (一社)日本外科学会 115回 IS - 4 2015/04 [Refereed]
  
• The Predictive Power of Serum α-Fetoprotein and Des-γ-Carboxy Prothrombin for Survival Varies by Tumor Size in Hepatocellular Carcinoma.

  Daisuke Tsugawa; Takumi Fukumoto; Masahiro Kido; Atsushi Takebe; Motofumi Tanaka; Kaori Kuramitsu; Ippei Matsumoto; Tetsuo Ajiki; Tatsuki Koyama; Yonson Ku

  The Kobe journal of medical sciences 61 (5) E124-31 - 31 0023-2513 2015/03 [Refereed]
   

  Alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) are frequently used as tumor markers in hepatocellular carcinoma (HCC). The authors hypothesized different patient populations with varying tumor sizes would influence the predictive power of tumor markers for survival in HCC patients. The authors investigated the influence of tumor size on predictive powers of AFP and DCP. 181 patients underwent hepatectomy for HCC from 2003 to 2008 at Kobe University Hospital. Tumor markers were measured before and at 1 month post-hepatectomy. The Cox proportional-hazards model revealed that preoperative serum AFP was associated with survival; its effects depended on tumor size. Hazard ratios (HRs) for preoperative AFP were maximum for medium-sized HCC, and for DCP, HRs were maximum in small-sized tumors. Post-hepatectomy, both tumor markers were associated with survival, revealing significant interactions with tumor size. HRs for postoperative AFP were greater than 1 for relatively wide range tumors (3-11 cm). HRs for postoperative DCP increased with tumor size, with a strong prognostic predictive power for tumors >5 cm. The predictive power of serum tumor markers varied by tumor size in HCC patients. By selecting the appropriate tumor marker, its predictive power can be improved.
• Perioperative management for pancreatoduodenectomy following severe acute pancreatitis in patients with periampullary cancer: our experience with six consecutive cases.

  Sadaki Asari; Ippei Matsumoto; Tetsuo Ajiki; Makoto Shinzeki; Tadahiro Goto; Takumi Fukumoto; Yonson Ku

  Surgery today SPRINGER 45 (2) 181 - 8 0941-1291 2015/02 [Refereed]
   

  PURPOSE: We rarely have an opportunity to perform pancreatoduodenectomy (PD) following the onset of severe acute pancreatitis (SAP) for patients with periampullary cancer. The perioperative risks and optimal timing of subsequent PD have, therefore, remained unclear. METHODS: Between January 2006 and December 2012, we performed PD in six patients with SAP. We reviewed these six cases, and compared the perioperative risks of morbidity and mortality with those of 81 concurrent PD patients matched for primary cancer without preoperative SAP. RESULTS: The six patients were classified as having SAP based on the Japanese criteria developed in 2008. The SAP in five patients was caused by ERCP procedures. The median interval from SAP onset to the operation was 111 days. The rate of Grade B/C postoperative pancreatic fistula formation in the SAP patients was significantly higher than that of the 81 control patients (83 vs. 26 %, P < 0.001). In addition, the median postoperative hospital stay was significantly longer in the six SAP patients relative to that of the control patients (40 vs. 30 days, P < 0.001). CONCLUSIONS: An interval of at least 3 months after surgery may be needed to decrease the inflammation of the peripancreas region after SAP. Therefore, unnecessary and low-yield ERCP procedures should be avoided in these patients.
• Reappraisal of peritoneal washing cytology in 984 patients with pancreatic ductal adenocarcinoma who underwent margin-negative resection.

  Sohei Satoi; Yoshiaki Murakami; Fuyuhiko Motoi; Kenichiro Uemura; Manabu Kawai; Masanao Kurata; Masayuki Sho; Ippei Matsumoto; Hiroaki Yanagimoto; Tomohisa Yamamoto; Masamichi Mizuma; Michiaki Unno; Yasushi Hashimoto; Seiko Hirono; Hiroki Yamaue; Goro Honda; Minako Nagai; Yoshiyuki Nakajima; Makoto Shinzeki; Takumi Fukumoto; A-Hon Kwon

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract SPRINGER 19 (1) 6 - 14 1091-255X 2015/01 [Refereed]
   

  OBJECTIVE: The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection. METHODS: In a 2001-2011 database from seven high-volume surgical institutions in Japan, 69 patients (7%) had positive CY (CY+ group) indicative of M1 disease and 915 patients had negative CY (CY- group). Clinicopathological data and survival were compared between groups. RESULTS: Significant correlations between CY+ and high CA19-9 level, pancreatic body and tail cancer, lymph node metastasis, and a lower frequency of R0 resection were observed. Overall survival (OS) of CY+ patients was significantly worse than that of CY- patients (median survival time [MST], 16 vs. 25 months; 3-year OS rate, 6 vs. 37%; p < 0.001). CY+ patients had a significantly higher rate of post-operative peritoneal carcinomatosis than CY- patients (48 vs. 21%; p < 0.001). Administration of adjuvant chemotherapy did not provide a favorable survival outcome to CY+ patients. The current study showed that patients with M1 disease had acceptable MST after margin-negative resection and a high incidence of peritoneal carcinomatosis within 3 years after surgery, resulting in decreased long-term survival. The development of a new strategy to control peritoneal carcinomatosis when surgical resection is performed in such patients is required.
• Preoperative bile replacement improves immune function for jaundiced patients treated with external biliary drainage.

  Yuko Yoshida; Tetsuo Ajiki; Kimihiko Ueno; Kenta Shinozaki; Sae Murakami; Taro Okazaki; Taku Matsumoto; Ippei Matsumoto; Takumi Fukumoto; Makoto Usami; Yonson Ku

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract SPRINGER 18 (12) 2095 - 104 1091-255X 2014/12 [Refereed]
   

  BACKGROUND: Although preoperative biliary drainage in jaundiced patients is controversial, external biliary drainage (EBD) is beneficial for infection control in patients with biliary cancers. When EBD is performed, additional bile replacement (BR) has the benefit of improving impaired intestinal barrier function, but the detailed mechanism remains unknown. We examined the effect of bile replacement on immune functions over the duration of BR in jaundiced patients. METHODS: Fifteen patients were enrolled into this prospective study. BR was started soon after the total serum bilirubin concentration reached 5.0 mg/dl and was continued for 14 days. Drained bile was given two times orally (2 × 100 ml/day). Concanavalin A (Con A)- and phytohemagglutinin (PHA)-stimulated lymphocyte proliferation and serum diamine oxidase (DAO) activity were measured before starting and during BR. Twenty patients with EBD and no BR were analyzed as a control group. RESULTS: Serum liver enzymes, prothrombin time-international normalized ratio (PT-INR), and responses to Con A and PHA gradually improved over the 14 days of BR, but percentages of lymphocytes and DAO levels did not. PT-INR, and Con A and PHA responses did not improve during EBD in the control group. PT-INR significantly decreased in patients with a greater fraction of their drained bile replaced. CONCLUSIONS: Our results indicate that preoperative BR using as large a quantity of bile as possible is useful for improving blood coagulability and cellular immunity in patients with EBD.
• [Re-resection for recurrent intrahepatic cholangiocarcinoma].

  Sae Murakami; Tetsuo Ajiki; Taro Okazaki; Taku Matsumoto; Yuko Yoshida; Kenta Shinozaki; Tadahiro Goto; Sadaki Asari; Makoto Shinzeki; Masahiro Kido; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy Japanese Journal of Cancer and Chemotherapy Publishers Inc. 41 (12) 1468 - 70 0385-0684 2014/11 [Refereed]
   

  INTRODUCTION: The benefits of re-resection for recurrent intrahepatic cholangiocarcinoma (IHC) are unknown. PATIENTS AND METHODS: We evaluated the comparative efficacy of different treatment schema for recurrent IHC following curative resection. RESULTS: Among 46 patients, 26 underwent R0 resection, while 20 underwent R1 resection. There were 13 cases of recurrence in R1 patients (65%), and 19 in R0 patients (61%). Recurrent IHC cases were divided into 3 groups based on the treatment received after recurrence: re-resection (n=5), chemotherapy (n=13), and best supportive care (BSC) (n=8). Survival times were evaluated for each group; median survival times (MSTs) after recurrence were 26, 14, and 4 months for the re-resection, chemotherapy, and BSC groups, respectively (p=0.030). Next, we examined the patients who only had intrahepatic recurrence; MSTs after recurrence for re-resection, chemotherapy, and BSC groups were 26, 14, and 5 months, respectively (p=0.0018). CONCLUSION: In recurrent IHC, survival time improves with re-resection or chemotherapy, when compared to BSC. In patients with intrahepatic recurrence only, re-resection is especially effective in prolonging survival.
• [Long-term survivor of unresectable bile duct cancer complicated with sclerosing cholangitis treated with chemotherapy].

  Taro Okazaki; Tetsuo Ajiki; Kenta Shinozaki; Yuko Yoshida; Sae Murakami; Taku Matsumoto; Makoto Shinzeki; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy Japanese Journal of Cancer and Chemotherapy Publishers Inc. 41 (12) 1542 - 4 0385-0684 2014/11 [Refereed]
   

  A 70-year-old woman was admitted to a near by hospital with complaints of epigastric pain and fever. Endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance cholangiopancreatography (MRCP) revealed stenosis of the hilar bile duct and multiple stenoses in the intrahepatic bile duct; bile cytological analysis indicated adenocarcinoma. The levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were within normal limits. It was very difficult to evaluate the extent of tumor invasion; therefore, we concluded that the tumor was unresectable. The patient underwent systemic chemotherapy with gemcitabine. After 5 years, she developed obstructive jaundice and cholangitis. The patient underwent endoscopic retrograde biliary drainage (ERBD), with 3 incidents of cholangitis recurrence. Although systemic chemotherapy with gemcitabine was performed for a long time, she died 6 years after the initiation of chemotherapy. Gemcitabine was administered 140 times in total, with a total dose of 203.744 g.
• [A case of resection of a metastatic liver tumor that recurred after particle beam therapy].

  Toshihiko Yoshida; Atsushi Takebe; Takumi Fukumoto; Masahiro Kido; Motofumi Tanaka; Kaori Kuramitsu; Hisoka Kinoshita; Daisuke Tsugawa; Kenji Fukushima; Takeshi Urade; Shinichi So; Tetsuo Ajiki; Ippei Matsumoto; Makoto Shinzeki; Taro Okazaki; Sadaki Asari; Tadahiro Goto; Taku Matsumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 41 (12) 2071 - 3 0385-0684 2014/11 [Refereed]
   

  Recently, the indications for particle beam therapy have been expanded to include metastatic liver tumors. However, its adverse effects on the treated liver are unclear, and the possibility of local recurrence after treatment should not be ignored. A 65-year-old man with advanced rectal carcinoma underwent low anterior resection. Resectable metastatic liver tumors were detected after adjuvant chemotherapy; however, he opted to undergo particle beam therapy. Nine months after treatment, a local recurrence was detected around the treated area, and central bisegmentectomy of the liver was performed as a salvage operation. The operation was technically complicated owing to severe adhesions and inflammatory changes in the liver parenchyma around the treated area. Pathological examination revealed advanced liver fibrosis at the treated area, in contrast with normal parenchyma in the untreated area. Although the procedure requires advanced surgical techniques, salvage surgery is a feasible option for recurrent liver tumors after particle beam therapy.
• [Long-term survival in a patient receiving multidisciplinary therapy for hepatocellular carcinoma with left iliac bone metastasis].

  Shinichi So; Masahiro Kido; Takumi Fukumoto; Atsushi Takebe; Motofumi Tanaka; Hisoka Kinoshita; Kaori Kuramitsu; Daisuke Tsugawa; Kenji Fukushima; Takeshi Urade; Toshihiko Yoshida; Sadaki Asari; Taro Okazaki; Makoto Shinzeki; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 41 (12) 2107 - 9 0385-0684 2014/11 [Refereed]
   

  The patient was a 79-year-old man diagnosed with a single 9.3-cm hepatocellular carcinoma (HCC) in the medial segment of the liver, and left iliac bone metastasis. Initially, the patient was treated with a hepatic arterial infusion of low-dose FP (cisplatin/5-fluorouracil) at another hospital. Here, the patient received particle therapy for the left iliac bone metastasis at a total dose of 52.8 Gy in 4 fractions. Subsequently, he underwent medial segmentectomy of the liver to treat the primary HCC. Eleven months later, the first intrahepatic recurrence occurred, and the tumor was treated with percutaneous radiofrequency ablation (RFA). A second intrahepatic recurrence was detected 39 months later, which was also treated with percutaneous RFA. The patient remains well, with no evidence of tumor recurrence.
• [A case of adjuvant surgery for a patient with initially unresectable locally advanced pancreatic cancer (LAPC) with a favorable response to S-1 chemotherapy].

  Azusa Ueta; Hirochika Toyama; Tadahiro Goto; Ippei Matsumoto; Makoto Shinzeki; Sadaki Asari; Jun Ishida; Yoshihide Nanno; Daisuke Tsugawa; Kaori Kuramitsu; Motofumi Tanaka; Atsushi Takebe; Taro Okazaki; Masahiro Kido; Tetsuo Ajiki; Takumi Fukumoto; Tatsuya Okuno; Mayu Kokubun; Tomoo Ito; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 41 (12) 2178 - 80 0385-0684 2014/11 [Refereed]
   

  A 67-year-old man was admitted to our hospital with a complaint of epigastric discomfort. A 29-mm hypovascular tumor was detected in the head of the pancreas by abdominal computed tomography imaging. As the superior mesenteric artery (SMA) was also involved, we diagnosed the tumor as unresectable pancreatic cancer. With S-1 chemotherapy, a radiological partial response was seen. After 4 courses of chemotherapy, a subtotal-stomach-preserving-pancreatoduodenectomy with dissection of the nerve plexus surrounding the SMA was performed. Although the tissue surrounding the SMA was hard, invasion of the SMA was not detected. Microscopic investigation revealed a few moderately differentiated adenocarcinoma cells in the fibrous tissue and the nerve fibers of pancreas. No cancer cells were found at the edges of the surgical specimen. The patient underwent R0 resection and a pathological evaluation showed Grade III tumor according to the Evans classification. After surgery, S-1 was interrupted because of diarrhea and local recurrence appeared 4 months postoperatively. For improving the prognosis of patients with pancreatic cancers, surgical intervention is often performed in patients with initially unresectable pancreatic cancers who have "long-term" favorable responses to chemotherapy or chemoradiotherapy. However, because of the possibility of relatively good prognosis with nonsurgical treatment for such patients and also the demerits of surgical stress, it is important to carefully consider the adjuvant surgery option.
• [Hassab's operation for left-sided portal hypertension after pancreatoduodenectomy].

  Tadahiro Goto; Ippei Matsumoto; Makoto Shinzeki; Hirochika Toyama; Sadaki Asari; Azusa Ueta; Jun Ishida; Yoshihide Nanno; Shinichi So; Hisoka Kinoshita; Taku Matsumoto; Kaori Kuramitsu; Motofumi Tanaka; Atsushi Takebe; Masahiro Kido; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 41 (12) 2214 - 6 0385-0684 2014/11 [Refereed]
   

  Here, we report a case of Hassab's operation for left-sided portal hypertension after pancreatoduodenectomy. A 69-year old man underwent pancreatoduodenectomy for pancreatic cancer in 2006 in which the splenic vein was ligated near the portal vein and then divided. The patient suffered repeated episodes of anemia between 2010 and 2013. However, we could not identify the bleeding site at that time. In 2011, local recurrence was detected. Disease progression occurred despite chemotherapy treatment, which was then discontinued. The left-sided portal hypertension gradually progressed, and the collateral vessels became dilated. In 2014, he was examined in our department for gastrointestinal bleeding. An upper gastrointestinal endoscopy revealed bleeding from gastric varices. Gastrointestinal bleeding ceased after endoscopic injection sclerotherapy ( EIS) was performed; however, the bleeding recurred. Balloon retrograde transvenous occlusion (BRTO) could not be performed because blood flow was not detected within the gastro-renal shunt. An emergency surgery was performed. Surgical splenectomy and devascularization (Hassab's operation) were performed. After surgery, the gastric body varices and gastrointestinal anastomosis disappeared and the bleeding did not occur. He is currently receiving outpatient treatment.
• 肝移植後長期生着を目指して

  蔵満 薫; 福本 巧; 福島 健司; 木下 秘我; 後藤 直大; 田中 基文; 浅利 貞毅; 武部 敦志; 新関 亮; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 47 (Suppl.2) 217 - 217 0386-9768 2014/10
• 胆道癌における内視鏡手術の妥当性 胆道癌に対する審査腹腔鏡の有用性

  味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 浅利 貞毅; 後藤 直大; 外山 博近; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 19 (7) 387 - 387 1344-6703 2014/10
• Factors affecting survival after resection of intrahepatic cholangiocarcinoma.

  Sae Murakami; Tetsuo Ajiki; Taro Okazaki; Kimihiko Ueno; Masahiro Kido; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  Surgery today SPRINGER 44 (10) 1847 - 54 0941-1291 2014/10 [Refereed]
   

  PURPOSE: This study aimed at assessing the prognostic factors of resection of intrahepatic cholangiocarcinoma (IHCC), which remain unclear. METHODS: Among 70 patients with IHCC, who were admitted to our hospital between 1998 and 2011, 45 (64 %) underwent resection and 25 had unresectable tumors. Univariate and multivariate analyses were conducted retrospectively to assess the factors influencing survival of the patients who underwent resection. RESULTS: The median survival times of the patients who underwent resection versus those who did not were 16 months versus 9 months, respectively (P < 0.001). Multivariate analysis identified residual tumor status (relative risk 4.12, P = 0.04) and pathological differentiation (relative risk 5.55, P = 0.04) as independent factors predicting survival. Patients who underwent R1 resection had a significantly higher rate of local recurrence than those who underwent R0 resection (P = 0.008). With R0 resection, there were no significant differences in patterns and rates of recurrence between patients with narrow (≤ 5 mm) versus wide (>5 mm) surgical margins. CONCLUSIONS: R0/1 resection and a well-differentiated tumor were found to be independent prognostic factors for long-term survival after IHCC resection. If R0 resection was achieved, the width of the negative surgical margin did not affect the patterns and rates of recurrence.
• Short- and long-term results of modified Frey's procedure in patients with chronic pancreatitis: a retrospective Japanese single-center study.

  Masaki Tanaka; Ippei Matsumoto; Makoto Shinzeki; Sadaki Asari; Tadahiro Goto; Hironori Yamashita; Jun Ishida; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  The Kobe journal of medical sciences 60 (2) E30-6 - 6 0023-2513 2014/08 [Refereed]
   

  BACKGROUND: The study aim was to determine the short- and long-term results of surgical drainage procedure for chronic pancreatitis at a single center in Japan. METHODS: The records of 28 consecutive patients were retrospectively reviewed. All patients underwent surgery at Kobe University Hospital between June 1999 and April 2013. Long-term follow-up was performed in all patients for a median period of 77 months. RESULTS: The 26 men (93%) and 2 women (7%) had a mean age of 47 years. The etiology of pancreatitis was chronic alcohol abuse in 24 patients (86%). The major indication for surgery was persistent symptoms (97%). Modified Frey's procedure in 21 patients, lateral pancreaticojejunostomy (LPJ) in 6 patients, LPJ and distal pancreatectomy in one patient, were performed. There was no postoperative mortality. Postoperative morbidity occurred in 6 patients (21%). The percentage of pain-free patients after surgery was 97%, and further acute exacerbation was prevented in 97%. Two patients (6%) required subsequent surgery for infectious pancreatic cyst and intraabdominal abscess. Of the patients that completed follow-up, 13 (46%) had diabetes mellitus, including 5 patients (19%) with new-onset diabetes, and 6 patients (19%) developed pancreatic exocrine insufficiency. CONCLUSIONS: Modified Frey's procedure is safe, feasible, and effective to manage chronic pancreatitis. The technique prevents further exacerbations and maintains appropriate pancreatic endocrine and exocrine function.
• 肝外胆管癌における術中迅速診断の役割

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 後藤 直大; 浅利 貞毅; 外山 博近; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  胆道 日本胆道学会 28 (3) 504 - 504 0914-0077 2014/08
• 膵頭十二指腸切除術における切離、吻合の工夫 安全・確実な膵空腸再建手術手技

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 69回 O - 6 2014/07
• 好中球/リンパ球比はBorderline resectable膵癌根治切除例に対する予後予測因子として有用である

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 味木 徹夫; 岡崎 太郎; 木戸 正浩; 武部 敦志; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 69回 O - 3 2014/07
• 膵癌術後長期無再発生存例の検討

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 69回 RS - 3 2014/07
• 胆道癌根治切除例における術前減黄中胆管炎・膵炎発生の治療成績への影響

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 69回 P - 5 2014/07
• 癌治療 標準化に向けた試み ガイドラインの検証 膵癌腹腔洗浄細胞診陽性患者に対する切除の意義はあるか?

  里井 壯平; 元井 冬彦; 上村 健一郎; 川井 学; 倉田 昌直; 庄 雅之; 松本 逸平; 柳本 泰明; 村上 義昭; 胆膵外科研究グループ

  日本消化器外科学会総会 (一社)日本消化器外科学会 69回 SY - 4 2014/07 [Refereed]
  
• Rapid progression of second bile duct cancer after resection for extrahepatic bile duct cancer

  Goto Tadahiro; Ajiki T; Murakami S; Matsumoto I; Shinzeki M; Asari S; Mukubou H; Okazaki T; Kido M; Fukumoto T; Ku Yonson

  International Cancer Conference Journal 3 (3) 173 - 177 2014/07 [Refereed]
  
• Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.

  Sae Murakami; Tetsuo Ajiki; Kimihiko Ueno; Hidehiro Sawa; Shinobu Tsuchida; Izuru Otsubo; Yuko Yoshida; Kenta Shinozaki; Taro Okazaki; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  Surgery today SPRINGER 44 (7) 1350 - 4 0941-1291 2014/07 [Refereed]
   

  A 25-year-old woman was referred to our hospital with persistent upper abdominal pain. Preoperative imaging studies revealed a hilar bile duct stricture with portal venous encasement, and the patient underwent curative resection involving extended left hepatectomy and segmental portal vein resection. The pathological findings demonstrated a well-differentiated tubular adenocarcinoma of the bile duct with regional lymph node metastasis (stage IIIB according to the UICC TNM classification), as well as the overexpression of p53 proteins and the K-ras gene mutation in tumor cells. The patient has shown no evidence of recurrence in the 10 months since the operation. Although there are several reports of relatively young adults with cholangiocarcinoma, the majority of such patients demonstrate either an anomalous arrangement of the pancreaticobiliary duct system or primary sclerosing cholangitis. The absence of any morphological abnormalities in this patient's biliary system implicates de novo carcinogenesis as the most likely cause of the cholangiocarcinoma.
• 膵癌に対する新たな治療戦略 切除可能膵癌 膵癌切除後早期再発の危険因子と予測スコア

  松本 逸平; 村上 義昭; 川井 学; 元井 冬彦; 上村 健一郎; 庄 雅之; 里井 壯平; 本田 五郎; 新関 亮; 浅利 貞毅; 後藤 直大; 白川 幸代; 石田 潤; 山上 裕機; 海野 倫明; 中島 祥介; 權 雅憲; 倉田 昌直; 福本 巧; 具 英成; 胆膵外科研究グループ

  膵臓 (一社)日本膵臓学会 29 (3) 390 - 390 0913-0071 2014/06
• T2胆嚢癌の治療方針 T2胆嚢癌の治療成績の検討

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 後藤 直大; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 26回 385 - 385 2014/06
• 進行度からみた十二指腸乳頭部癌切除例の検討

  松本 拓; 味木 徹夫; 岡崎 太郎; 村上 冴; 吉田 優子; 篠崎 健太; 蔵満 薫; 後藤 直大; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 26回 424 - 424 2014/06
• 膵頭十二指腸切除と尾側膵切除の術後耐糖能の比較検討

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 蔵満 薫; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 26回 442 - 442 2014/06
• 黄色肉芽腫性胆嚢炎切除後に遺残胆嚢癌を発症した1例

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 吉田 優子; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 植田 亜津紗; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 26回 535 - 535 2014/06
• 胆道癌切除例における胆道再建の工夫

  味木 徹夫; 吉田 優子; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 木戸 正浩; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 26回 727 - 727 2014/06
• 膵癌術前予後予測因子としてのFDG-PETの有用性

  松本 逸平; 山下 博成; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 南野 佳英; 植田 亜津紗; 松本 拓; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本癌治療学会誌 (一社)日本癌治療学会 49 (3) 1077 - 1077 0021-4671 2014/06
• 進行胆道癌に対する塩酸ゲムシタビンによる術後補助療法の成績

  味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 松本 逸平; 浅利 貞毅; 後藤 直大; 木戸 正浩; 福本 巧; 具 英成

  日本癌治療学会誌 (一社)日本癌治療学会 49 (3) 1349 - 1349 0021-4671 2014/06
• 膵癌根治切除患者における腹腔洗浄細胞診検査の臨床的意義

  里井 壯平; 村上 義昭; 元井 冬彦; 川井 学; 倉田 昌直; 庄 雅之; 松本 逸平; 柳本 泰明; 山本 智久; 上村 健一郎; 海野 倫明; 山上 裕機; 本田 五郎; 木下 正一; 新関 亮; 權 雅憲; Multicenter Study Group of Pancreatobiliary Surgery(MSG-PB)

  膵臓 日本膵臓学会 29 (3) 377 - 377 0913-0071 2014/06 [Refereed]
  
• 膵頭部癌に対する門脈合併切除は予後を改善するか

  村上 義昭; 里井 壯平; 上村 健一郎; 元井 冬彦; 川井 学; 本田 五郎; 倉田 昌直; 庄 雅之; 赤堀 宇広; 松本 逸平; 浅利 貞毅; 柳本 泰明; 海野 倫明; 山上 裕機; Multicenter Study Group of Pancreatobiliary Surgery(MSG-PBS)

  膵臓 日本膵臓学会 29 (3) 378 - 378 0913-0071 2014/06 [Refereed]
  
• 大動脈周囲リンパ節転移陽性膵癌の手術成績 多施設共同研究822例の解析結果

  庄 雅之; 村上 義昭; 元井 冬彦; 里井 壮平; 松本 逸平; 川井 学; 本田 五郎; 上村 健一郎; 柳本 泰明; 倉田 昌直; 後藤 直大; 赤堀 宇広; 海野 倫明; 山上 裕機; 中島 祥介; MSG-PBS

  日本癌治療学会誌 (一社)日本癌治療学会 49 (3) 831 - 831 0021-4671 2014/06 [Refereed]
  
• A prospective randomized comparison between pylorus- and subtotal stomach-preserving pancreatoduodenectomy on postoperative delayed gastric emptying occurrence and long-term nutritional status.

  Ippei Matsumoto; Makoto Shinzeki; Sadaki Asari; Tadahiro Goto; Sachiyo Shirakawa; Tetsuo Ajiki; Takumi Fukumoto; Yasuyuki Suzuki; Yonson Ku

  Journal of surgical oncology WILEY-BLACKWELL 109 (7) 690 - 6 0022-4790 2014/06 [Refereed]
   

  BACKGROUND AND OBJECTIVES: Pylorus-preserving pancreatoduodenectomy (PPPD) has been associated with a high incidence of delayed gastric emptying (DGE). There are few studies comparing DGE associated with PPPD and subtotal stomach-preserving pancreatoduodenectomy (SSPPD). Moreover, differences between the procedures with respect to long-term results have not been reported. A prospective randomized study was conducted to compare perioperative complications and long-term nutritional status with PPPD and SSPPD. METHODS: One hundred patients with periampullary lesions were randomized to receive either PPPD (n = 50) or SSPPD (n = 50). All patients were followed up for 3 years after surgery or to the time of recurrence to evaluate nutritional status for the study. The effects of the procedure, age, and malignancy on changes in nutritional indicators were estimated with linear mixed models. This study was registered at UMIN Clinical Trials Registry (UMIN 000012337). RESULTS: The incidence of DGE assessed by the International Study Group of Pancreatic Surgery was 20% with PPPD and 12% with SSPPD (P = 0.414). There were no significant differences between the two procedures on postoperative serum albumin levels, serum total cholesterol levels, and body mass index during the 3-year follow-up period. CONCLUSIONS: SSPPD is equally effective in DGE occurrence rate and long-term nutritional status comparing to PPPD.
• Evaluation of glucose metabolism after distal pancreatectomy according to the donor criteria of the living donor pancreas transplantation guidelines proposed by the Japanese Pancreas and Islet Transplantation Association.

  I Matsumoto; M Shinzeki; S Asari; T Goto; S Shirakawa; T Ajiki; T Fukumoto; Y Ku

  Transplantation proceedings 46 (3) 958 - 62 2014/04 

  BACKGROUND: Living donor pancreas transplantation (LDPT) reduces the number of deaths of diabetic patients on dialysis and of candidates on the waiting lists and helps to overcome the organ shortage. Stringent criteria must be applied to minimize the risk of metabolic complications for living donors. The Japanese Pancreas and Islet Transplantation Association (JPITA) proposed LDPT guidelines in 2010. In this study, we retrospectively evaluated glucose metabolism of the patients who underwent distal pancreatectomy (DP) according to the donor criteria of the LDPT guidelines proposed by the JPITA. METHODS: Fifty-two nondiabetic patients who underwent DP were divided into 2 groups according to the donor criteria: indication group (IG, n = 14) who had age ≤ 65, hemoglobin A1c (HbA1c) < 5.9%, and body mass index (BMI) < 25 kg/m(2). The other patients were placed in the no indication group (NG, n = 38). Clinical data and percent resected volume (PRV) of each pancreas as determined by multi-detector row computed tomography volumetry were compared between the 2 groups. RESULTS: During the follow-up period (median 12 months), 14 patients (27%) developed new-onset diabetes within a median onset time of 10 months (range 3-24 months) postoperatively. No patient in the IG developed new-onset diabetes. On the other hand, 37% of the patients in the NG developed new-onset diabetes. There were significant between-group differences in changes in preoperative serum fasting glucose and HbA1c levels, whereas there were no significant between-group differences in preoperative serum albumin or body weight. Multivariate analysis identified preoperative HbA1c (odds ratio 51.6, P = .002) and PRV (odds ratio 2.07, P = .033) as independent risk factors for new-onset diabetes. CONCLUSION: Living donor criteria in the LDPT guidelines proposed by the JPITA are appropriate for prevention of glucose metabolic complications in donors. Further long-term follow-up studies of living donors' metabolic function are needed to clarify the safety of the donor.
• Functioning pancreas graft with thromboses of splenic and superior mesenteric arteries after simultaneous pancreas-kidney transplantation: a case report.

  I Matsumoto; M Shinzeki; S Asari; T Goto; S Shirakawa; T Ajiki; T Fukumoto; Y Ku

  Transplantation proceedings 46 (3) 989 - 91 2014/04 

  Graft thrombosis is the most common cause of early graft loss after pancreas transplantation. The grafted pancreas is difficult to salvage after complete thrombosis, especially arterial thrombosis, and graft pancreatectomy is required. We describe a patient presenting with a functioning pancreas graft with thromboses of the splenic artery (SA) and superior mesenteric artery (SMA) after simultaneous pancreas-kidney transplantation (SPK). A 37-year-old woman with a 20-year history of type 1 diabetes mellitus underwent SPK. The pancreaticoduodenal graft was implanted in the right iliac fossa with enteric drainage. A Carrel patch was anastomosed to the recipient's right common iliac artery, and the graft gastroduodenal artery was anastomosed to the common hepatic artery using an arterial I-graft. The donor portal vein was anastomosed to the recipient's inferior vena cava. Four days after surgery, graft thromboses were detected by Doppler ultrasound without increases in the serum amylase and blood glucose levels. Contrast enhanced computed tomography revealed thromboses in the SA, splenic vein and SMA. Selective angiography showed that blood flow was interrupted in the SA and SMA. However, pancreatic graft perfusion was maintained by the I-graft in the head of the pancreas and the transverse pancreatic artery in the body and tail of the pancreas. We performed percutaneous direct thrombolysis and adjuvant thrombolytic therapy. However, we had to stop the thrombolytic therapy because of gastrointestinal hemorrhage. Thereafter, the postoperative course was uneventful and the pancreas graft was functioning with a fasting blood glucose level of 75 mg/dL, HbA1c of 5.1%, and serum C-peptide level of 1.9 ng/mL at 30 months post-transplantation.
• MDCTによる膵頭部癌の膵外神経叢浸潤に関する術前評価基準の検討

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 松本 拓; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 115 (臨増2) 297 - 297 0301-4894 2014/03
• 膵頭十二指腸切除が膵内分泌機能に及ぼす影響について

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 115 (臨増2) 901 - 901 0301-4894 2014/03
• 非切除進行、再発胆道癌に対するGEM、S-1段階的治療の成績

  味木 徹夫; 岡崎 太郎; 村上 冴; 吉田 優子; 篠崎 健太; 松本 拓; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 木戸 正浩; 福本 巧; 豊田 昌徳; 具 英成

  日本消化器病学会雑誌 (一財)日本消化器病学会 111 (臨増総会) A293 - A293 0446-6586 2014/03
• Long-term outcomes and prognostic factors with reductive hepatectomy and sequential percutaneous isolated hepatic perfusion for multiple bilobar hepatocellular carcinoma.

  Takumi Fukumoto; Masahiro Tominaga; Masahiro Kido; Atsushi Takebe; Motofumi Tanaka; Kaori Kuramitsu; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku

  Annals of surgical oncology SPRINGER 21 (3) 971 - 8 1068-9265 2014/03 [Refereed]
   

  BACKGROUND: Sorafenib is currently recommended as first-line therapy for patients with intermediate or advanced hepatocellular carcinoma (HCC) per Barcelona Clinic Liver Cancer staging. However, the median overall survival (OS) with sorafenib in these patients is 10.7 months with an overall response rate of 2 %. We retrospectively investigated the long-term outcomes and prognostic factors with reductive hepatectomy and sequential percutaneous isolated hepatic perfusion (PIHP) for refractory intermediate or advanced HCC. METHODS: A total of 68 patients who had intermediate or advanced stage HCC without extrahepatic metastases were scheduled for reductive hepatectomy plus PIHP. All patients underwent reductive hepatectomy and PIHP with mitomycin C 20-40 mg/m(2) and/or doxorubicin 60-120 mg/m(2) 1-3 months after surgery (mean, 1.51 times/patient). RESULTS: The objective response rate of PIHP was 70.6 % (complete plus partial response). The median OS of all 68 patients was 25 months, and the 5-year OS rate was 27.6 %. Univariate and multivariate analyses indicated that tumor response to PIHP and normalization of serum des-γ-carboxy prothrombin concentrations after PIHP were independent prognostic factors for OS. CONCLUSIONS: The median OS of the study population treated by reductive hepatectomy and sequential PIHP was 25 months. This treatment strategy can offer a possible curative treatment to patients with refractory intermediate and advanced HCC.
• Two-Layer Challenge Test As An Assessment To Predict Islet Graft Function

  Tadahiro Goto; Yasuhiro Fujino; Masaru Kanashiro; Yasuki Tanioka; Tetsuya Sakai; Takuro Yoshikawa; Ippei Matsumoto; Yasuyuki Suzuki; Yonson Ku; Yoshikazu Kuroda

  HEPATO-GASTROENTEROLOGY H G E UPDATE MEDICAL PUBLISHING S A 61 (130) 502 - 506 0172-6390 2014/03 [Refereed]
   

  Background/Aims: To investigate graft viability assessment before transplantation using P-31-Nuclear Magnetic Resonance (NMR) spectroscopy combining a two-layer old storage method (TLM). Methodology: Rat pancreases were divided into three groups and respectively subjected to 0 (group1); and 30 minutes (group 2) of warm ischemia (WI) before procurement. Pancreases were digested and pancreatic digest tissues were preserved for 3 h using TLM. P-31-NMR spectroscopy was used to measure ATP levels of digest tissue. After TLM, the ratio of beta-adenosine triphosphate to phosphate monoester (beta ATP/PME) obtained by P-31-NMR spectroscopy was evaluated. Isolated islets were assessed for yield and in vivo function separately using nude mice. Results: The beta ATP/PME ratios were 0.11 +/- 0.04, and 0.03 +/- 0,01 in groups 1 and 2, respectively (P<0.05). Islet yields (IEQ/pancreas) were significantly less in group 3 (P<0.05) and the cure rate after transplantation of 200 islets to athymic nude mice were 100% (7/7), and 0% (0/7) in groups 1 and 2, respectively. We regard groups 1 as viable group and group 2 as non-viable group. The viable groups and the non-viable group were clearly distinguished by beta ATP/PME ratios. Conclusion: P-31-NMR spectroscopy combining TLM provided an objective and rapid means to assess severity of islet graft damage prior to transplantation in the rat model.
• 膵中央切除術後膵腸縫合不全に対し緊急手術を施行した1例

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 田中 正樹; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本腹部救急医学会雑誌 (一社)日本腹部救急医学会 34 (2) 512 - 512 1340-2242 2014/02
• 亜全胃温存膵頭十二指腸切除術後5ヵ月で胃空腸吻合部の穿孔により腹膜炎をきたした1例

  松本 拓; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 蔵満 薫; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本腹部救急医学会雑誌 (一社)日本腹部救急医学会 34 (2) 538 - 538 1340-2242 2014/02
• Influence of preoperative anti-cancer therapy on resectability and perioperative outcomes in patients with pancreatic cancer: project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

  Fuyuhiko Motoi; Michiaki Unno; Hidenori Takahashi; Takaho Okada; Keita Wada; Masayuki Sho; Hiroaki Nagano; Ippei Matsumoto; Sohei Satoi; Yoshiaki Murakami; Masashi Kishiwada; Goro Honda; Hisafumi Kinoshita; Hideo Baba; Shoichi Hishinuma; Minoru Kitago; Hidehiro Tajima; Hiroyuki Shinchi; Hiroshi Takamori; Tomoo Kosuge; Hiroki Yamaue; Tadahiro Takada

  Journal of hepato-biliary-pancreatic sciences SPRINGER JAPAN KK 21 (2) 148 - 58 1868-6974 2014/02 [Refereed]
   

  BACKGROUND: Little is known about the effects of neoadjuvant therapy on outcomes in patients with pancreatic cancer. This study evaluated the effects of neoadjuvant therapy on resectability and perioperative outcomes. METHODS: A total of 992 patients were enrolled, with 971 deemed eligible. Of these, 582 had resectable tumors and 389 had borderline resectable tumors, and 388 patients received neoadjuvant therapy. Demographic characteristics and peri- and postoperative parameters were assessed by a questionnaire survey. RESULTS: The R0 rate was significantly higher in patients with resectable tumors who received neoadjuvant therapy than in those who underwent surgery first, but no significant difference was noted in patients with borderline resectable tumors. Operation time was significantly longer and blood loss was significantly greater in patients who received neoadjuvant therapy than in those who underwent surgery first, but there were no significant differences in specific complications and mortality rates. The node positivity rate was significantly lower in the neoadjuvant than in the surgery-first group, indicating that the former had significantly lower stage tumors. CONCLUSIONS: Neoadjuvant therapy may not increase the mortality and morbidity rate and may be able to increase the chance for curative resection against resectable tumor.
• Contrast-enhanced intraoperative ultrasonic cholangiography for real-time biliary navigation in hepatobiliary surgery.

  Takeshi Urade; Takumi Fukumoto; Motofumi Tanaka; Masahiro Kido; Atsushi Takebe; Kaori Kuramitsu; Masashi Chuma; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku

  Journal of the American College of Surgeons ELSEVIER SCIENCE INC 218 (2) e43-50 - E50 1072-7515 2014/02 [Refereed]
  
• Erratum: Respiratory-gated 18F-FDG PET/CT for the diagnosis of liver metastasis (European Journal of Radiology (2013) 82:10 (1696-1701))

  Yuko Suenaga; Kazuhiro Kitajima; Hajime Aoki; Takashi Okunaga; Atsushi Kono; Ippei Matsumoto; Takumi Fukumoto; Kenichi Tanaka; Kazuro Sugimura

  European Journal of Radiology Elsevier Ireland Ltd 83 (4) 741  1872-7727 2014 [Refereed]
  
• Gallbladder bed pocket score as a preoperative measure for assessing the difficulty of laparoscopic cholecystectomy.

  Kenta Shinozaki; Tetsuo Ajiki; Taro Okazaki; Kimihiko Ueno; Taku Matsumoto; Izuru Ohtsubo; Sae Murakami; Yuko Yoshida; Ippei Matsumoto; Takumi Fukumoto; Takemi Sugimoto; Masakazu Ohno; Yonson Ku

  Asian journal of endoscopic surgery 6 (4) 285 - 91 1758-5902 2013/11 [Refereed]
   

  INTRODUCTION: Laparoscopic cholecystectomy (Lap-C) is a standard surgery for symptomatic gallbladder stones and acute or chronic cholecystitis. Resident surgeons often perform this operation early in their training, but they sometimes encounter difficulties for various technical reasons. Although encountering a gallbladder buried deep within the gallbladder bed is a common operative difficulty, literature on the subject scarcely exists. METHODS: Forty-two patients underwent Lap-C at our hospitals and were analyzed retrospectively. We defined the gallbladder bed pocket score (GBPS) as the maximum ratio between the height and width of the gallbladder bed measured based on multi-detector computed tomography (MDCT) images. GBPS and clinical factors were assessed in terms of their correlation with the time required for gallbladder dissection from the gallbladder bed. RESULTS: Of the 42 patients, 20 had histories of acute or chronic cholecystitis. The mean gallbladder dissection time was 14.9 min, and the mean GBPS was 0.43 in the coronal MDCT section and 0.56 in the sagittal section. The correlation coefficient between the GBPS and gallbladder dissection time was 0.40 (P = 0.01) in the coronal section and 0.38 (P = 0.02) in the sagittal section of the MDCT images. There was no statistically significant correlation between gallbladder dissection time and the surgeon's experience, patient's history of cholecystitis, gallstone size, or blood loss. However, GBPS > 0.4 predicted more difficult and prolonged dissection. CONCLUSION: GBPS is a useful tool for preoperatively predicting the time needed to dissect the gallbladder from the gallbladder bed during Lap-C. Cases with GBPS < 0.4 seem more suitable for resident surgeons who are performing gallbladder dissection early in their Lap-C training.
• MUC2 expression and prevalence of high-grade dysplasia and invasive carcinoma in mixed-type intraductal papillary mucinous neoplasm of the pancreas

  Atsuhiro Masuda; Yoshifumi Arisaka; Shigeo Hara; Ippei Matsumoto; Mamoru Takenaka; Arata Sakai; Hideyuki Shiomi; Nobuyuki Matsuki; Maki Sugimoto; Tsuyoshi Fujita; Takanobu Hayakumo; Yonson Ku; Shuji Ogino; Takeshi Azuma; Hiromu Kutsumi

  PANCREATOLOGY KARGER 13 (6) 583 - 588 1424-3903 2013/11 [Refereed]
   

  Background/objectives: Morphological types and mucin protein expressions classify intraductal papillary mucinous neoplasms (IPMNs). Main duct (MD)-IPMN mostly consists of intestinal type (I-type), which expresses MUC2. Branch duct (BD)-IPMN mostly consists of gastric type (G-type), which does not express MUC2. However, the definition of mixed-type IPMN has yet to be clarified and it contains various histological types. The aim of this study was to investigate the relationship between MUC2 expression and the presence of high-grade dysplasia (HGD) and invasive carcinoma, especially in mixed-type IPMN. Methods: This retrospective study included 101 consecutive patients with surgically resected IPMNs between April 2001 and October 2012. All patients were morphologically classified into four distinct types (I-type, G-type, PB-type: pancreatobilliary, O-type: oncocytic) and immunohistochemical reactivity of various anti-mucin antibodies were investigated. Results: According to the classification of the 2012 international guidelines, the numbers (and histomorphological types: I/G/PB/O) of MD, mixed-type, and BD-IPMNs were 16 (12/4/0/0), 45 (16/28/1/0), and 40 (0/38/1/1). Prevalence of MUC2 expression in MD, mixed-type, and BD-IPMNs were 75% (12/16), 36% (16/45), and 0% (0/40). In mixed-type IPMN, the prevalence of HGD and/or invasive carcinoma in MUC2-positive IPMN was significantly higher than that of MUC2-negative IPMN (HGD + invasive carcinoma: 88% vs. 38%, p = 0.0017; invasive carcinoma: 50% vs. 21%, p = 0.042). Multivariate analysis showed that MUC2 expression is an independent predictive factor of HGD and invasive carcinoma in mixed IPMN (odds ratio 14.6, 95% CI 2.5-87.4, p = 0.003). Conclusions: In mixed-type IPMN, MUC2 expression clearly identified HGD and invasive carcinoma and may provide most appropriate surgical indication. Copyright (C) 2013, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
• [Analysis of the safety and efficacy of percutaneous isolated hepatic perfusion after particle therapy for advanced hepatocellular carcinoma].

  Motofumi Tanaka; Takumi Fukumoto; Masahiro Kido; Atsushi Takebe; Kaori Kuramitsu; Hisoka Kinoshita; Shohei Komatsu; Kenji Fukushima; Takeshi Urade; Shinichi So; Makoto Shinzeki; Ippei Matsumoto; Tetsuo Ajiki; Kazuki Terashima; Osamu Fujii; Yusuke Demizu; Nobukazu Fuwa; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 40 (12) 1681 - 3 0385-0684 2013/11 [Refereed]
   

  Here, we report the efficacy of dual treatment with hepatic resection and percutaneous isolated hepatic perfusion (PIHP) for advanced hepatocellular carcinoma( HCC). Recently, we introduced treatment with combined particle therapy and PIHP for unresectable HCC in cases of insufficient liver function. The purpose of this study was to evaluate the safety and efficacy of PIHP for local control in the liver after particle therapy. From 2006 to 2013, 6 patients underwent particle therapy for the main lesion and subsequent PIHP for remnant liver lesions. Their mean age was 64 years, and the mean size of the main lesion was 6.2 cm (range, 2.0-10.8 cm). All patients had liver cirrhosis. After particle therapy, PIHP was performed by hepatic arterial infusion of 100 mg/m2 of doxorubicin and 30 mg/m2 of mitomycin C. With regard to side effects, neutropenia occurred in all patients but no serious hepatobiliary injury was observed. The response rate for PIHP was 50% (partial response: 3 and stable disease: 3). The mean overall survival time was 26.9 months after particle therapy. In conclusion, even after particle therapy, PIHP is a safe treatment and is associated with a good local control rate for remnant HCCs. Further accumulation of data is needed to evaluate the efficacy of this treatment strategy in terms of prognosis.
• [A case involving long-term survival following bile duct cancer with para-aortic lymph node metastasis that was treated by multidisciplinary therapy].

  Isamu Yamada; Kenta Shinozaki; Tetsuo Ajiki; Taro Okazaki; Yuko Yoshida; Sae Murakami; Izuru Otsubo; Sachiyo Shirakawa; Masaki Tanaka; Hideyo Mukubo; Naohiro Goto; Sadaki Asari; Makoto Shinzeki; Masahiro Kido; Ippei Matsumoto; Takumi Fukumoto; Masao Murakami; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 40 (12) 1741 - 3 0385-0684 2013/11 [Refereed]
   

  Complete resection of advanced bile duct cancer is difficult due to the anatomical location of the tumor and invasion into other organs. Even if a complete resection is achieved, the survival rates of patients with bile duct cancer after surgery are lower as compared to those associated with other gastrointestinal tumors. Certain cases with para-aortic lymph node metastasis have a poor prognosis. In the present report, we describe a case involving long-term survival following bile duct cancer that was treated by multidisciplinary therapy (particle radiotherapy, surgical resection, chemotherapy). In the present case, we detected lymph node (LN) metastasis only in LN#16, but not in LN#13 or LN#17. We believe that particle radiotherapy, consisting of proton and carbon-ion, can be used to control the lymphatic metastasis around the pancreas head and hepatoduodenal ligament. Our findings suggest that particle radiotherapy can be a standard neoadjuvant therapy for bile duct cancer.
• [A case of initially unresectable gallbladder cancer with surgical resection after chemotherapy with gemcitabine].

  Sae Murakami; Tetsuo Ajiki; Kenta Shinozaki; Yuko Yoshida; Izuru Ohtsubo; Taro Okazaki; Tadahiro Goto; Sadaki Asari; Makoto Shinzeki; Masahiro Kido; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 40 (12) 1744 - 6 0385-0684 2013/11 [Refereed]
   

  A 75-year-old woman was admitted to our hospital with elevated serum hepatic enzyme levels. After evaluation with imaging studies, she was diagnosed as having gallbladder cancer, which had invaded the liver and hepatic artery, with lymph node metastases. The tumor was considered unresectable, and the patient received chemotherapy with gemcitabine (GEM)alone. Six months later, computed tomography(CT)indicated shrinkage of the gallbladder tumor and disappearance of lymph node metastases. Surgical resection was planned. However, liver metastasis was suspected on the basis of macroscopic findings, and the patient underwent gallbladder bed resection. Pathological examination indicated that almost all of the tumor cells in the gallbladder were viable; however, there were no tumor cells in the liver nodule and lymph node. The postoperative course was uneventful. The patient received adjuvant chemotherapy with GEM and was alive without recurrence 17 months after tumor resection. Immunohistochemical analysis showed that 80.9% of the tumor cells were positive for CD133, a cancer stem cell marker. This case illustrates a possible relationship between cancer stem cells and chemoresistance.
• [The role of preoperative percutaneous isolated hepatic perfusion and hepatectomy in multidisciplinary treatment].

  Toshihiko Yoshida; Masahiro Kido; Takumi Fukumoto; Shohei Komatsu; Masanori Takahashi; Atsushi Takebe; Motofumi Tanaka; Kaori Kuramitsu; Hisoka Kinoshita; Tetsuo Ajiki; Ippei Matsumoto; Makoto Shinzeki; Taro Okazaki; Sadaki Asari; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 40 (12) 1822 - 4 0385-0684 2013/11 [Refereed]
   

  We report a case of multiple bilobar hepatocellular carcinoma( HCC) that was successfully treated with a multidisciplinary treatment including preoperative percutaneous isolated hepatic perfusion and hepatectomy. The patient was a 61- year-old man who was detected as having HCC mainly in segment 4 and 8 of the liver and multiple bilobar intrahepatic metastasis during follow-up evaluation for chronic hepatitis B. Curative resection was difficult because the patient had insufficient liver function and because of the location of the tumor. Hence, we performed preoperative percutaneous isolated hepatic perfusion (PIHP) to control the multiple HCC. Seven weeks after the PIHP, the tumor size had reduced, and therefore we performed an extended left hepatic lobectomy. In addition to these treatment modalities, we performed transcatheter arterial chemoembolization (TACE) 3 times owing to recurrent HCC in the right liver lobe. Considering that HCC in segment 8 can be treated with TACE, we performed partial hepatectomy. As of the last follow-up visit, the patient was alive without disease recurrence. Thus, preoperative PIHP may improve the resectability rate in patients with multiple bilobar HCC for which curative resection is difficult to perform.
• [A case of metachronous pancreatic cancer that developed 4 years after initial pancreatectomy].

  Jun Ishida; Ippei Matsumoto; Makoto Shinzeki; Sadaki Asari; Tadahiro Goto; Masaki Tanaka; Hironori Yamashita; Masahiro Kido; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 40 (12) 1893 - 6 0385-0684 2013/11 [Refereed]
   

  A 55-year-old woman underwent subtotal stomach-preserving pancreaticoduodenectomy for pancreatic ductal adenocarcinoma( PDAC) in July 2008. The final diagnosis was Stage I PDAC according to the Union for International Cancer Control( UICC) TNM classification. After the operation, adjuvant chemotherapy with gemcitabine was administered for 6 months. The tumor marker level increased at 49 months after the operation, and 18-fluoro-deoxyglucose (FDG)-positron emission tomography( PET) showed FDG accumulation in the remnant pancreas. A hypovascular tumor was revealed in the remnant pancreas on computed tomography( CT). As PDAC was diagnosed without distant metastasis, completion pancreatectomy was performed. Histopathological investigation revealed PDAC with invasion into the muscularis propria of the anastomosed jejunum and splenic plexus. The final diagnosis was T3N0M0 UICC Stage IIA metachronous PDAC. The postoperative course was uneventful. However, multiple liver metastases and local recurrence were detected on CT 2 months after resection, and the patient died 3 months after resection. Most reported cases of metachronous PDACs were diagnosed at an advanced stage despite regular follow-ups after the initial resection. Further investigation is needed to determine the adequate surveillance time and novel therapeutic strategies.
• Three-dimensional Computed Tomographic Cholangiography as a Novel Diagnostic Tool for Evaluation of Bile Duct Invasion of Perihilar Cholangiocarcinoma

  Tetsuo Ajiki; Takumi Fukumoto; Kimihiko Ueno; Taro Okazaki; Ippei Matsumoto; Yonson Ku

  HEPATO-GASTROENTEROLOGY H G E UPDATE MEDICAL PUBLISHING S A 60 (128) 1833 - 1840 0172-6390 2013/11 [Refereed]
   

  Background/Aims: This study assessed the results of preoperative evaluation of ductal invasion by perihilar cholangiocarcinoma, imaged using 3-dimensional (3D) CT cholangiography compared to conventional endoscopic retrograde cholangiography (ERC) and magnetic resonance cholangiopancreatography (MRCP). Methodology: ERC, MRCP and 3D-CT cholangiography were planned in 24 patients with preoperatively diagnosed perihilar cholangiocarcinoma. Evaluations of bile duct images using each of 3 modalities were classified into 2 groups (the Visualization uncertain (VU) group and the Visualization certain and clear (VCC) group) according to the quality, of biliary images. The results of pathological assessments and preoperative radiological evaluations were compared. Results: In the bile duct evaluation, the rates between the 2 groups were not significantly different across the three modalities. 3D-CT cholangiography evaluated tumour involvement most clearly in patients with obstructive jaundice (p = 0.044), and ERC evaluated biliary tree more clearly compared to MRCP or 3D-CT cholangiography in patients without obstructive jaundice (p = 0.051). For evaluation of pathological tumor invasion in the VCC group, 3D-CT cholangiography enabled a correct diagnosis in 7 of 11 patients, and R0 resection was achieved in 8 of 11 patients. Conclusions: 3D-CT cholangiography offers accurate preoperative assessment of bile duct invasion by perihilar cholangiocarcinoma, especially in patients with obstructive jaundice.
• 再発癌の治療戦略(肝・胆・膵) 残膵癌に対する治療戦略

  石田 潤; Matsumoto Ippei; Asari Sadaki; Goto Tadahiro; 田中 正樹; 山下 博成; 味木 徹夫; 福本 巧; Ku Yonson

  日本臨床外科学会雑誌 日本臨床外科学会 74 (増刊) 366 - 366 1345-2843 2013/10
• 腹部固形癌に対する粒子線とスペーサー外科手術を用いた治療限界の克服

  木下 秘我; 福本 巧; 宗 慎一; 浦出 剛史; 福島 健司; 中馬 正志; 小松 昇平; 蔵満 薫; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 46 (Suppl.2) 180 - 180 0386-9768 2013/10
• Respiratory-gated ¹⁸F-FDG PET/CT for the diagnosis of liver metastasis.

  Yuko Suenaga; Kazuhiro Kitajima; Hajime Aoki; Takashi Okunaga; Atsushi Kono; Ippei Matsumoto; Takumi Fukumoto; Kenichi Tanaka; Kazuro Sugimura

  European journal of radiology ELSEVIER IRELAND LTD 82 (10) 1696 - 701 0720-048X 2013/10 [Refereed]
   

  PURPOSE: To ascertain the role of respiratory-gated PET/CT with (18)F-fluorodeoxyglucose ((18)F-FDG) for accurate diagnosis of liver metastasis. MATERIALS AND METHODS: Forty patients with suspected liver metastasis underwent conventional whole-body PET/CT scan initially, followed by respiratory-gated PET/CT scan covering the liver. Visual detectability (using a 5-point confidence scale), maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) of hepatic metastatic lesions were assessed for three data sets including ordinary whole-body (WB) scan, and non-respiratory-gated (nRG) and respiratory-gated (RG) scans. Results of enhanced CT and/or MRI, or clinical and radiological follow-up were used for reference. RESULTS: Sixteen of the patients were found to have 53 metastatic lesions in the liver. Patient-based accuracy of WB, nRG, and RG was 92.5%, 95.0%, and 97.5%, respectively, with a lesion-based detection rate of 67.9%, 73.6%, and 73.6%, respectively. The average SUVmax of 34 liver metastatic lesions for WB, nRG, and RG was 6.60 ± 2.34, 7.19 ± 2.66, and 8.08 ± 3.24, respectively. SUVmax for RG was significantly higher than that for WB (p=0.0069). The average MTV of these 40 lesions for the three protocols was 5.32 ± 4.78 cm(3), 5.07 ± 4.73 cm(3), and 4.73 ± 4.67 cm(3), respectively. Among the three protocols, RG showed the best visual and quantitative evaluation for diagnosis of liver metastasis. CONCLUSION: Respiratory-gated PET/CT allows more accurate identification of liver metastases than non-respiratory-gated PET/CT.
• 胆嚢癌切除後経過中に遺残膵内胆管癌を発症した膵・胆管合流異常の一例

  松本 拓; 篠崎 健太; 吉田 優子; 村上 冴; 岡崎 太郎; Goto Tadahiro; Asari Sadaki; 新関 亮; 木戸 正浩; Matsumoto Ippei; 味木 徹夫; 福本 巧; 具 英成

  日本膵・胆管合流異常研究会プロシーディングス 日本膵・胆管合流異常研究会 36 65 - 65 1883-4116 2013/09 [Refereed]
  
• 非切除進行・再発胆道癌に対する2次治療としてのS-1投与の役割

  味木 徹夫; 岡崎 太郎; 村上 冴; 吉田 優子; 篠崎 健太; 松本 拓; 松本 逸平; 新関 亮; 浅利 貞毅; 木戸 正浩; 福本 巧; 具 英成

  日本癌治療学会誌 (一社)日本癌治療学会 48 (3) 978 - 978 0021-4671 2013/09
• 膵切除後の短期・長期合併症に対する予防策とその根拠 尾側膵切除後の新規糖尿病発症予測因子としての膵切除量の検討

  白川 幸代; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 68回 SY - 10 2013/07
• IPMNに対する縮小手術の適応

  新関 亮; 松本 逸平; 浅利 貞毅; 後藤 直大; 椋棒 英世; 白川 幸代; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 68回 O - 6 2013/07
• 膵切除後腹腔内出血に対する治療戦略

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 椋棒 英世; 田中 正樹; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 68回 O - 1 2013/07
• 腹腔動脈幹合併膵体尾部切除術後の仮性動脈瘤出血に対して、TAEと開腹ドレナージにより救命した一例

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 石田 潤; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 68回 P - 9 2013/07
• 膵癌長期生存例の検討

  田中 正樹; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 68回 RS - 6 2013/07
• 腎癌膵転移に対して二度の膵切除を行った一例 当科における腎癌膵転移症例の検討

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 岩崎 寿光; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 68回 P - 1 2013/07
• 癌幹細胞マーカーCD133の発現からみたIPNBと膵IPMNの類似性

  味木 徹夫; 村上 冴; 岡崎 太郎; 大坪 出; 吉田 優子; 篠崎 健太; 堀 裕一; 松本 逸平; 新関 亮; 木戸 正浩; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 25回 426 - 426 2013/06
• 肝胆膵外科手術への術前シミュレーションサージェリーの応用 肝胆道外科領域における当科の術前シミュレーションの取り組み

  田中 基文; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 浦出 剛史; 松本 逸平; 味木 徹夫; 福本 巧; 杉本 真樹; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 25回 223 - 223 2013/06
• 18-Fluorodeoxyglucose positron emission tomography does not aid in diagnosis of pancreatic ductal adenocarcinoma.

  Ippei Matsumoto; Sachiyo Shirakawa; Makoto Shinzeki; Sadaki Asari; Tadahiro Goto; Tetsuo Ajiki; Takumi Fukumoto; Kazuhiko Kitajima; Yonson Ku

  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association ELSEVIER SCIENCE INC 11 (6) 712 - 8 1542-3565 2013/06 [Refereed]
   

  BACKGROUND & AIMS: There are no accurate and reliable tools for diagnosis of early stage pancreatic ductal adenocarcinoma (PDA) or small metastatic lesions. It is also a challenge to differentiate PDA from focal mass-forming pancreatitis (FMP). There is controversy regarding the efficacy of 18-fluorodeoxyglucose positron-emission tomography (FDG-PET) in the diagnosis of PDA. We investigated whether FDG-PET provides information that, combined with data from other imaging techniques, can aid in decision making for patients with suspected PDA. METHODS: We performed a retrospective analysis of data collected from 232 consecutive patients with suspected PDA at Kobe University Hospital from January 2006 through June 2012. All patients underwent a diagnostic imaging protocol that included multidetector row computed tomography, superparamagnetic iron oxide-enhanced magnetic resonance imaging, and FDG-PET. Based on endoscopic ultrasonography, fine-needle aspiration biopsy, or endoscopic retrograde cholangiopancreatography analyses, 218 patients had PDA (89 underwent resection and 129 did not) and 14 patients had FMP (8 had focal mass-forming chronic pancreatitis and 6 had focal mass-forming autoimmune pancreatitis). RESULTS: FDG-PET detected 50% of stages 0 and I, 91.9% of stage II, 100% of stage III, and 96.8% of stage IV tumors. Detection was affected significantly by tumor size (P = .024) and T stage (P = .023) in resected tumors. Multidetector row computed tomography detected significantly more liver metastases than FDG-PET. Few para-aortic lymph node or peritoneal metastases were detected by FDG-PET. FDG-PET correctly identified 11 of the 14 patients with FMP (5 of 8 with focal mass-forming chronic pancreatitis and 6 of 6 with focal mass-forming autoimmune pancreatitis). CONCLUSIONS: FDG-PET is not effective in detecting early stage PDA and small metastases, or in differentiating PDA from FMP. Combining FDG-PET with current diagnostic techniques for PDA did not provide any decisive information, therefore it should not be included in this analysis.
• Lymphadenectomy combined with locoregional treatment for multiple advanced hepatocellular carcinoma with lymph node metastases.

  Masahide Awazu; Takumi Fukumoto; Atsushi Takebe; Tetsuo Ajiki; Ippei Matsumoto; Masahiro Kido; Motofumi Tanaka; Kaori Kuramitsu; Yonson Ku

  The Kobe journal of medical sciences 59 (1) E17-27 - 27 0023-2513 2013/04 [Refereed]
   

  Lymphadenectomy of lymph node metastasis (LNM) from hepatocellular carcinoma (HCC) may potentially improve survival of patients with intrahepatic tumors controllable by means of locolegional treatment. However, the treatment strategy has not gained wide clinical acceptance, especially in patients with multiple advanced HCC. Thus, the purpose of this study is to evaluate the role of lymphadenectomy combined with locoregional treatment for the management of multiple advanced HCC with LNM. Between January 1998 and August 2012, 15 patients underwent a selective lymphadenectomy either concurrently or sequentially after hepatectomy. Seven of 15 patients underwent reductive hepatectomy while the remaining 8 patients had hepatectomy at curative intent. In patients with reductive hepatectomy, lymphadenectomy was concurrently performed and the residual intrahepatic tumors were treated thereafter with additional locoregional treatments consisting of transcatheter arterial chemoembolization, radiofrequency ablation, and percutaneous isolated hepatic perfusion. Only 4 patients (26.6%) of 15 patients developed lymph node recurrence. However, intrahepateic recurrence was encountered in 13 of 15 patients. The median survival time after lymphadenectomy was 25.2 months with the overall survival rates at 1, 2, and 3 years being 76.9%, 52.7%, and 26.4%, respectively. Selective lymphadenectomy and multimodal locoregional treatment in patients with multiple residual tumors exhibited a similar overall survival to complete resection of LNM and intrahepatic tumors (P=0.78). Lymphadenectomy combined with an additional aggressive locoregional treatments may be justified in selected patients with multiple advanced HCC with LNM.
• 粘液産生胆管腫瘍(IPNB)からの細胞株樹立

  村上 冴; 味木 徹夫; 堀 裕一; 篠崎 健太; 吉田 優子; 大坪 出; 岡崎 太郎; 松本 逸平; 福本 巧; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 114 (臨増2) 405 - 405 0301-4894 2013/03
• An extremely rare portal annular pancreas for pancreaticoduodenectomy with a special note on the pancreatic duct management in the dorsal pancreas.

  Ippei Matsumoto; Makoto Shinzeki; Takumi Fukumoto; Yonson Ku

  Surgery MOSBY-ELSEVIER 153 (3) 434 - 6 0039-6060 2013/03 [Refereed]
  
• [A case of groove pancreatitis associated with duodenal ulcer].

  Takao Iemoto; Hideyuki Shiomi; Atsuhiro Masuda; Tsuyoshi Sanuki; Hiromu Kutsumi; Takanobu Hayakumo; Makoto Shinzeki; Ippei Matsumoto; Yonson Ku; Maki Kanzawa; Shigeo Hara; Takeshi Azuma

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 110 (1) 88 - 94 0446-6586 2013/01 [Refereed]
   

  We describe a 69-year-old man with a history of multiple gastroduodenal ulcers, presenting with the onset of obstructive jaundice. Abdominal CT, MRI and EUS demonstrated a sheet-like mass in the pancreaticoduodenal groove. EUS-FNA did not reveal malignancy. Conservative treatment did not improve his clinical condition and repeated acute pancreatitis occurred during his treatment. Thus, pancreaticoduodenectomy was performed. Histopathological findings showed a duodenal ulcer penetrating the pancreas and infiltration of inflammatory cells and fibrosis in the pancreaticoduodenal groove. The spread of inflammation associated with the duodenal ulcer may have been one of the causes of groove pancreatitis.
• 腹腔鏡下尾側膵切除術 導入と術式の定型化へ向けて

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Takebe Atsushi; Takahashi Masanori; Okazaki Taro; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 17 (7号) 557 - 557 1344-6703 2012/12 [Refereed]
  
• 腹腔鏡下尾側膵切除術における術中出血への対策

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Okazaki Taro; Takahashi Masanori; Takebe Atsushi; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 17 (7号) 557 - 557 1344-6703 2012/12 [Refereed]
  
• 肝硬変症例に対する腹腔鏡下胆嚢摘出術の成績

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 17 (7号) 615 - 615 1344-6703 2012/12 [Refereed]
  
• 術前経皮的肝灌流と肝切除で完全奏効した両葉多発肝細胞癌の1例

  Takebe Atsushi; Fukumoto Takumi; Kito Masahiro; tsutida Shinobu; Takahashi Masanori; Tanaka Motofumi; Kuramitsu Kaori; Toyama Hirochika; Shinzeki Makoto; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  新薬と臨床 (株)医薬情報研究所 61 (12) 2677 - 2677 0559-8672 2012/12
• 低侵襲手術ナビゲーション最前線 Virtual 3D画像と臓器立体モデル 肝臓外科領域における当科の術前シミュレーション・術中ナビゲーションの取り組み

  Tanaka Motofumi; Sugimoto Maki; Ajiki Tetsuo; Matsumoto Ippei; Kito Masahiro; Shinzeki Makoto; Takahashi Masanori; Asari Sadaki; Takebe Atsushi; Kuramitsu Kaori; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 17 (7) 236 - 236 1344-6703 2012/12 [Refereed]
  
• Pancreatic volumetric assessment as a predictor of new-onset diabetes following distal pancreatectomy.

  Sachiyo Shirakawa; Ippei Matsumoto; Hirochika Toyama; Makoto Shinzeki; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract SPRINGER 16 (12) 2212 - 9 1091-255X 2012/12 [Refereed]
   

  INTRODUCTION: Pancreatogenic diabetes after pancreatectomy is of growing importance due to the increasing life expectancy of pancreatectomized patients. Although reduction of pancreatic volume is thought to affect glucose metabolism, a consistent relationship has yet to be determined. This study aimed to investigate functional consequences of distal pancreatectomy (DP) in preoperatively non-diabetic patients. METHODS: This study included 61 non-diabetic patients who underwent DP. Clinical data were obtained, and the percent resected volume (PRV) of each pancreas was determined via multi-detector row computed tomography volumetry. RESULTS: During the follow-up period (median 26 months), 22 patients (36 %) developed new-onset diabetes within a median onset time of 8 months (range 0.5-42 months) postoperatively. The remaining 39 patients also showed impaired glucose metabolism. Multivariate analysis identified preoperative hemoglobin A1c ≥ 5.7 % (odds ratio 15.6, p = 0.001) and PRV > 44 % (odds ratio 11.3, p = 0.004) as independent risk factors for new-onset diabetes. CONCLUSIONS: Key determinants of postoperative glycemic control include preoperative functional reserve of the endocrine pancreas and the volume reduction of pancreatic parenchyma. Our findings enable reliable preoperative evaluation of the risk of postoperative diabetes and appropriate postoperative surveillance, which is helpful for early intervention in high risk patients.
• A case of lymphoepithelial cyst of pancreas with unique "cheerios-like" appearance in EUS.

  Wen Gao; Atsuhiro Masuda; Ippei Matsumoto; Makoto Shinzeki; Hideyuki Shiomi; Mamoru Takenaka; Nobuyuki Matsuki; Eiji Funatsu; Tsuyoshi Fujita; Yoshifumi Arisaka; Takanobu Hayakumo; Shigeo Hara; Yonson Ku; Takeshi Azuma; Hiromu Kutsumi

  Clinical journal of gastroenterology 5 (6) 388 - 92 1865-7257 2012/12 [Refereed]
   

  Lymphoepithelial cyst (LEC) of the pancreas is a rare benign lesion, which is difficult to diagnose preoperatively. We describe a case of a 60-year-old male, incidentally diagnosed as having LEC of the pancreas, which was managed by laparoscopic distal pancreatectomy. Most of the reported cases of LEC were asymptomatic and diagnosed incidentally. A high index of suspicion under EUS may help in making a diagnosis and avoiding unnecessary surgery in asymptomatic patients. In particular, the unique "cheerios-like" appearance of the lesion in EUS, which was also found in this case, might be helpful in the differential diagnosis of pancreatic cystic lesions.
• Role of intraoperative cholangiography in patients whose biliary tree was evaluated preoperatively by magnetic resonance cholangiopancreatography.

  Kimihiko Ueno; Tetsuo Ajiki; Hidehiro Sawa; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  World journal of surgery SPRINGER 36 (11) 2661 - 5 0364-2313 2012/11 [Refereed]
   

  BACKGROUND: Routine performance of intraoperative cholangiography (IOC) during cholecystectomy is controversial. The aim of this study was to evaluate the role of IOC during cholecystectomy in addition to preoperative magnetic resonance cholangiopancreatography (MRCP) in our institution over a 12-year period. METHODS: A total of 425 consecutive patients who underwent IOC during cholecystectomy were included in this study. MRCP was performed preoperatively for bile duct evaluation in all patients. When common bile duct (CBD) stones were detected, they were removed endoscopically before the operation. We estimated the results of IOC in terms of the success rate, the detection rate of anatomic abnormality of the biliary system, and the incidence of residual CBD stones. RESULTS: MRCP preoperatively identified 6 (1.4 %) patients with abnormal biliary systems and 56 with CBD stones, which were endoscopically removed. The success rate of IOC was 93.8 % (399/425). Abnormalities of the biliary system were detected in 12 patients (12/399, 3.0 %) and CBD stones in 8 (8/399, 2.0 %). Of the eight patients with stones, seven had been examined by endoscopy preoperatively and found to have CBD stones. The detection rate of bile duct stones in patients with preoperative endoscopic removal of CBD stones (7/56, 12.5 %) was significantly higher than those with CBD stones first detected during IOC (1/365, 0.3 %) (p < 0.01). Moreover, no residual CBD stones were detected in patients who were operated on within fewer than 12 days from endoscopic treatment to the operation. CONCLUSIONS: IOC is indicated even after preoperative sphincterotomy for CBD stones. In our study, it resulted in a 12.5 % incidence of persistent stones after sphincterotomy. IOC plays an additional role in detecting CBD stones and in revealing abnormalities of the biliary tree in patients whose biliary tree was preoperatively evaluated by MRCP.
• Duodenal protrusion by carcinosarcoma of the extrahepatic bile duct.

  Masaki Tanaka; Tetsuo Ajiki; Ippei Matsumoto; Sadaki Asari; Takumi Fukumoto; Atsuhiro Masuda; Hideyuki Shiomi; Takanobu Hayakumo; Yonson Ku

  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society WILEY-BLACKWELL 24 (6) 484 - 484 0915-5635 2012/11 [Refereed]
  
• Feasibility of (18)F-fluorodeoxyglucose positron-emission tomography for preoperative evaluation of biliary tract cancer.

  Isamu Yamada; Tetsuo Ajiki; Kimihiko Ueno; Hidehiro Sawa; Izuru Otsubo; Yuko Yoshida; Makoto Shinzeki; Hirochika Toyama; Ippei Matsumoto; Takumi Fukumoto; Atsunori Nakao; Joji Kotani; Yonson Ku

  Anticancer research INT INST ANTICANCER RESEARCH 32 (11) 5105 - 10 0250-7005 2012/11 [Refereed]
   

  (18)F-Labeled fluorodeoxyglucose positron-emission tomography (FDG-PET), a rapidly evolving functional imaging modality, has recently been shown to be useful in the diagnosis and staging of various malignant tumors due to focal uptake of FDG-labeled glucose in malignant cell populations. However, the role of FDG-PET in the diagnosis and staging of biliary tract cancer is still controversial and has not yet been fully evaluated. The aim of this study was to determine the clinical importance of FDG-PET in the preoperative evaluation of biliary tract cancer and retrospectively clarify the characteristics of false-negative and false-positive cases. We retrospectively analyzed data for 73 consecutive patients diagnosed with cancer of the biliary tract and were admitted to the Department of Hepato-Biliary-Pancreatic Surgery at Kobe University Hospital for treatment, from January 2007 to August 2009. Since the sensitivity, specificity and positive predictive value (PPV) of FDG-PET in the diagnosis of bile duct carcinoma are usually relatively high, FDG-PET is considered to be a useful tool in diagnosing biliary tract cancer. FDG-PET also seems to be useful in clinical decision-making, regarding treatment strategy, including surgery. Our results showed that FDG-PET is highly sensitive in delineating the primary focus of biliary cancer and is a useful tool in preoperative examination. A disadvantage of FDG-PET is its inability to indicate small metastases and false-positive findings of inflamed gallbladder and bile duct lesions.
• [A case of bilobar multiple hepatocellular carcinoma in which complete remission was achieved by preoperative percutaneous isolated hepatic perfusion and subsequent hepatectomy].

  Takeshi Urade; Motofumi Tanaka; Takumi Fukumoto; Masahiro Kido; Shinobu Tsuchida; Masanori Takahashi; Atsushi Takebe; Kaori Kuramitsu; Masahide Awazu; Masashi Chuma; Kenji Fukushima; Shinichi So; Kentaro Tai; Masato Fujimoto; Hirochika Toyama; Makoto Shinzeki; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 39 (12) 1825 - 7 0385-0684 2012/11 [Refereed]
   

  We report a case of bilobar multiple hepatocellular carcinoma (HCC) successfully treated by preoperative percutaneous isolated hepatic perfusion(PIHP) and subsequent hepatectomy. A 77-year-old man with elevated serum PIVKA-II level and hepatomas was referred to our hospital. Abdominal dynamic computed tomography and gadoxetate disodium-enhanced magnetic resonance imaging demonstrated advanced HCCs: 11 tumors with a maximum tumor size of 4.8 cm diameter in the right lobe, and 1 tumor of 3.6 cm diameter in the left lobe. Curative resection was impossible due to insufficient liver function and due to the locations of the tumors. Therefore, we performed preoperative PIHP in order to control the multiple HCCs in the right lobe. This resulted in normalization of serum PIVKA-II level and complete necrosis of all tumors in the right lobe, as observed on dynamic computed tomography after 4 weeks of PIHP. Then, at 7 weeks after PIHP, we performed extended left lobectomy for residual tumor in the left lobe. Finally, complete remission was thought to have been achieved. The patient is alive 6 months after PIHP, without recurrence.
• [Three cases of recurrent bile duct cancer diagnosed and treated by double-balloon endoscopy].

  Kenta Shinozaki; Tetsuo Ajiki; Taro Okazaki; Yuko Yoshida; Sae Murakami; Izuru Ohtsubo; Sachiyo Shirakawa; Masaki Tanaka; Hidehiro Sawa; Tadahiro Goto; Sadaki Asari; Kimihiko Ueno; Hirochika Toyama; Makoto Shinzeki; Masahiro Kido; Ippei Matsumoto; Takumi Fukumoto; Takanobu Hayakumo; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 39 (12) 1877 - 9 0385-0684 2012/11 [Refereed]
   

  Local recurrences often develop after the resection of bile duct cancer. Imaging modalities do not have sufficient sensitivity or specificity to enable the definite diagnosis of recurrent bile duct cancer, and it may be difficult to decide when to start chemotherapeutic treatment. It is difficult to obtain specimens by conventional endoscopy after Roux-Y biliary reconstruction. The double-balloon endoscope(DBE) has 2 balloons: one at the tip of the endoscope and the other at the over- tube. The 2 balloons are inflated alternately and the endoscope can move through the small intestine in a caterpillar-like manner. DBE simplifies the approach to Roux-Y choledochojejunostomy and to obtaining a pathological specimen. Moreover, endoscopic biliary drainage and cholangiography can be performed with the DBE. Recently, the DBE has enabled systemic chemotherapy to be started after obtaining pathological evidence of malignancy, as well as biliary drainage instead of percutaneous transhepatic biliary drainage in cases with recurrent bile duct cancers. Here, we present 3 cases of recurrent bile duct cancer diagnosed and treated by a DBE.
• [A case of postoperative liver metastasis from pancreatic carcinoma treated with percutaneous isolated hepatic perfusion(PIHP)].

  Hirochika Toyama; Ippei Matsumoto; Makoto Shinzeki; Sachiyo Shirakawa; Masaki Tanaka; Hironori Yamashita; Tetsuo Ajiki; Kimihiko Ueno; Hidehiro Sawa; Izuru Otsubo; Sae Murakami; Masahiro Kido; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 39 (12) 1886 - 8 0385-0684 2012/11 [Refereed]
   

  We report a case of postoperative liver metastasis arising from pancreatic carcinoma treated with a novel procedure that we developed-percutaneous isolated hepatic perfusion (PIHP). A 69-year-old man diagnosed with pancreatic body cancer(pT3, pN0, pStage III) was treated using distal pancreatectomy and adjuvant therapy with gemcitabine(GEM). Six months later, a metastasis to the medial segment of the liver was found using computer tomography(CT). The patient was treated by chemotherapy with S-1, but the liver metastasis grew, and we therefore employed PIHP as the third-line therapy, using 80 mg doxorubicin (DXR) and 62 mg mitomycin C (MMC). Six weeks after PIHP, the tumor marker carbohydrate antigen 19-9( CA19-9) had decreased from 44,469 to 4,268 U/mL, and the carcinoembryonic antigen(CEA) level decreased from 28.8 to 5.4 U/mL. Although the size of the carcinoma remained the same on CT, some cells had liquefied as a result of necrosis. However, the patient died about 1 year after PIHP due to the growth of liver metastasis, peritoneal metastasis, and local recurrence, reflected by a progressively increasing level of tumor marker. In this case, PIHP seemed to be ineffective due to local recurrence and peritoneal metastasis as well as early enlargement of liver metastasis. However, the reduction in tumor marker levels and the observed tumor necrosis, suggest that PIHP is a potentially effective and promising treatment for liver metastasis arising from pancreatic carcinoma.
• [Long-term survival in 2 cases with unresectable hilar bile duct cancer and sclerosing cholangitis].

  Izuru Ohtsubo; Tetsuo Ajiki; Taro Okazaki; Kenta Shinozaki; Yuko Yoshida; Sae Murakami; Makoto Shinzeki; Masahiro Kido; Ippei Matsumoto; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 39 (12) 2122 - 4 0385-0684 2012/11 [Refereed]
   

  Case 1: A 69-year-old man was admitted to a nearby clinic due to upper abdominal pain. Computed tomography revealed stenosis of the hilar bile duct and dilation of the intrahepatic bile duct in both lobes of the liver. A percutaneous transhepatic biliary drainage tube was inserted in the right anterior segment branch, and an endoscopic naso-biliary drainage tube was inserted in the left hepatic duct. He was referred to our hospital because of suspected hilar bile duct cancer. Radiographic examination showed severe stenosis of the hepatic hilar duct and tapering of the entire intrahepatic bile duct. The extent of invasion could not be evaluated and we concluded that the tumor was unresectable. Although systemic chemotherapy with gemcitabine was performed, the patient died at 37 months after the start of chemotherapy. Case 2: A 70- year-old woman was admitted to a nearby hospital due to epigastric pain and fever. Endoscopic retrograde cholangiopancreatography revealed stenosis of the hilar bile duct and a wide range of multiple stenosis in the intrahepatic bile duct. Bile cytology showed adenocarcinoma. Therefore, we decided the tumor was unresectable. Systemic chemotherapy with gemcitabine was started. She is in good health 57 months after the start of chemotherapy.
• [A case of interstitial lung disease associated with gemcitabine treatment in a patient with locally advanced pancreatic cancer following proton beam radiotherapy].

  Masaki Tanaka; Ippei Matsumoto; Makoto Shinzeki; Hirochika Toyama; Sadaki Asari; Tadahiro Goto; Sachiyo Shirakawa; Hironori Yamashita; Hidehiro Sawa; Kimihiko Ueno; Masanori Takahashi; Shinobu Tsuchida; Masahiro Kido; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 39 (12) 2158 - 60 0385-0684 2012/11 [Refereed]
   

  A 69-year-old woman who had locally advanced pancreatic cancer underwent proton beam radiotherapy(67.5 GyE/25 Fr) concurrent with gemcitabine chemotherapy (GEM 800 mg/m2 day 1, 8) at Hyogo Ion Beam Medical Center, followed by GEM chemotherapy (1,000 mg/m2 day 1, 8, 15/28 day)at Kobe University Hospital. She visited our hospital because she was suffering from dyspnea 212 days after first administration of GEM. A chest computed tomography revealed that infiltrations were spreading in the bilateral lung fields. A bronchoscopy showed diffuse alveolar hemorrhage. We diagnosed GEM related interstitial lung disease with diffuse alveolar hemorrhage. We introduced steroid pulse therapy (methylprednisolone 1 g/day) for 3 days followed by oral prednisolone (40 mg/day), which was tapered gradually. She recovered and was discharged on the 24th day after admission.
• 胆嚢癌との鑑別診断が困難であった黄色肉芽腫性胆嚢炎の1例

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌 日本臨床外科学会 73 (増刊) 925 - 925 1345-2843 2012/10 [Refereed]
  
• 腹腔鏡下膵切除術 腹腔鏡下尾側膵切除術 安全な術式の定型化

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Takebe Atsushi; Takahashi Masanori; Okazaki Taro; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌 日本臨床外科学会 73 (増刊) 417 - 417 1345-2843 2012/10 [Refereed]
  
• 膵癌鑑別診断および術前診断におけるFDG-PETの位置づけ

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Okazaki Taro; Takahashi Masanori; Takebe Atsushi; Kito Masahiro; Fukumoto Takumi; Ajiki Tetsuo

  日本臨床外科学会雑誌 73 (増刊) 557  2012/10 [Refereed]
  
• Hepatomesenteric typeの肝動脈走行変異を伴う十二指腸乳頭部癌に対してSSPPDを施行した1例

  Ajiki Tetsuo; Asari Sadaki; Okazaki Taro; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌 73 (増刊) 760  2012/10 [Refereed]
  
• 門脈腫瘍栓(Vp4)合併肝細胞癌に対する肝切除の工夫と集学的治療としてのPIHPの有効性

  Tanaka Motofumi; Kito Masahiro; Kusunoki Nobuya; Takahashi Masanori; Takebe Atsushi; Kuramitsu Kaori; Shinzeki Makoto; Matsumoto Ippei; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌 日本臨床外科学会 73 (増刊) 501 - 501 1345-2843 2012/10
• ソナゾイドによる術中超音波胆道造影を用いた肝切除術

  Fukumoto Takumi; Kito Masahiro; Takahashi Masanori; Takebe Atsushi; Tanaka Motofumi; Kuramitsu Kaori; Shinzeki Makoto; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  日本臨床外科学会雑誌 日本臨床外科学会 73 (増刊) 627 - 627 1345-2843 2012/10
• Hanging maneuverを用いた巨大肝細胞癌に対する安全な肝右肝切除術

  Takebe Atsushi; Fukumoto Takumi; Takahashi Masanori; Tanaka Motofumi; Ajiki Tetsuo; Matsumoto Ippei; Shinzeki Makoto; Ku Yonson

  日本臨床外科学会雑誌 日本臨床外科学会 73 (増刊) 504 - 504 1345-2843 2012/10
• Multiple solid pancreatic hamartomas: A case report and review of the literature.

  Fumi Kawakami; Michio Shimizu; Hiroshi Yamaguchi; Shigeo Hara; Ippei Matsumoto; Yonson Ku; Tomoo Itoh

  World journal of gastrointestinal oncology BAISHIDENG PUBLISHING GROUP INC 4 (9) 202 - 6 1948-5204 2012/09 [Refereed]
   

  Non-neoplastic tumor-like lesions in the pancreas are uncommon. Here, we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman. Her computed tomography revealed a pancreatic mass, measuring 1.8 cm in maximum diameter. However, no symptoms were found. She was not an alcoholic and had no history of pancreatitis. The patient underwent a pancreatoduodenectomy, and three well-demarcated solid nodules measuring 1.7 cm, 0.4 cm, and 0.3 cm in diameter were found in the pancreatic head. Microscopically, the lesions were composed of non-neoplastic, disarranged acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells that lacked discrete islets. The stromal spindle cells were immunoreactive for CD34 and CD117. The histological diagnosis was multiple solid hamartomas of the pancreas. There has been no recurrence 30 mo after surgery. So far, 18 cases of pancreatic hamartoma have been reported in the English literature, including our case. Six out of these 18 cases seemed to fit the criteria of solid pancreatic hamartoma. Although the number of cases was limited, solid pancreatic hamartomas seem to be benign tumor-like lesions, which are found incidentally in healthy middle-aged adults, but occasionally involve the whole pancreas, resulting in a poor prognosis. Solid pancreatic hamartoma was sometimes associated with minor pancreatic abnormality, and multiple small lesions other than the main tumors were detected in a small number of cases. From these findings, one may speculate that solid pancreatic hamartoma could be the result of a malformation during the development of the pancreas.
• 門脈血栓症を合併した症例に対する門脈再建術の検討

  Kuramitsu Kaori; Fukumoto Takumi; Tanaka Motofumi; Takebe Atsushi; Takahashi Masanori; Kito Masahiro; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  移植 (一社)日本移植学会 47 (総会臨時) 182 - 182 0578-7947 2012/09
• 肝胆道手術における術前シミュレーションと術中ナビゲーションの取り組み

  田中 基文; 杉本 真樹; 上野 公彦; 木戸 正浩; 外山 博近; 新関 亮; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 67回 1 - 1 2012/07
• 腹腔鏡下ラジオ波焼灼術におけるNon Trocar Techniqueの有用性

  tsutida Shinobu; Fukumoto Takumi; Ajiki Tetsuo; Kusunoki Nobuya; Matsumoto Ippei; Kito Masahiro; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Takahashi Masanori; Asari Sadaki; Tanaka Motofumi; Kuramitsu Kaori; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回 (一社)日本肝胆膵外科学会 24回 302 - 302 2012/05
• 肉腫成分を含む肝内胆管癌および混合型肝癌の2例

  Kito Masahiro; Fukumoto Takumi; tsutida Shinobu; Tanaka Motofumi; Kuramitsu Kaori; Ajiki Tetsuo; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Kawakami Fumi; Itoh Tomoo; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回 (一社)日本肝胆膵外科学会 24回 412 - 412 2012/05
• 当施設におけるmodified Hanging Maneuverを用いた肝葉切除の工夫

  Kito Masahiro; Fukumoto Takumi; tsutida Shinobu; Tanaka Motofumi; Kuramitsu Kaori; Ajiki Tetsuo; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回 (一社)日本肝胆膵外科学会 24回 290 - 290 2012/05
• 肝切除における残肝体積と予備能のコンセンサス再考 肝細胞癌における術式選択 幕内基準を超えて

  Fukumoto Takumi; Kuramitsu Kaori; Tanaka Motofumi; Takahashi Masanori; Kito Masahiro; tsutida Shinobu; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回 (一社)日本肝胆膵外科学会 24回 207 - 207 2012/05
• Repeating regional acute pancreatitis in the head of the pancreas caused by intraductal papillary mucinous neoplasms in the tail: report of a case.

  Sadaki Asari; Ippei Matsumoto; Hirochika Toyama; Makoto Shinzeki; Tadahiro Goto; Sachiyo Shirakawa; Isamu Yamada; Tetsuo Ajiki; Takumi Fukumoto; Tomoo Ito; Yonson Ku

  Surgery today SPRINGER 42 (4) 398 - 402 0941-1291 2012/04 [Refereed]
   

  Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a distinct entity characterized by papillary proliferations of mucin-producing epithelial cells with excessive mucin production and cystic dilatation of the pancreatic ducts. The clinical presentation often involves recurrent episodes of pancreatitis associated with the temporal obstruction of the main pancreatic duct caused by the hypersecretion of mucin. We herein describe a case in which the patient repeatedly experienced the occurrence of idiopathic acute pancreatitis in the head of the pancreas over a 9-year period, and who was ultimately was cured by distal pancreatectomy for IPMNs in the pancreatic tail. This case illustrates the potential pitfalls in the diagnosis of IPMNs owing to a discrepancy between the site of pancreatitis and that of the IPMN. The possible mechanisms linking acute pancreatitis with the formation of IPMNs are also reviewed.
• 生体肝移植後腎機能障害に対する予測式を用いた新たな治療戦略

  Kuramitsu Kaori; Fukumoto Takumi; Tanaka Motofumi; Takahashi Masanori; Kito Masahiro; tsutida Shinobu; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  日本外科学会雑誌 (一社)日本外科学会 113 (臨増2) 384 - 384 0301-4894 2012/03
• 遊走胆嚢に対して単孔式腹腔鏡下胆嚢摘出術を施行した1例

  浦出 剛史; 味木 徹夫; 沢 秀博; 上野 公彦; 木戸 正浩; 松本 逸平; 楠 信也; 福本 巧; 堀 裕一; 具 英成

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 16 (7) 574 - 574 1344-6703 2011/12
• 新規臓器圧排用器具エンドラクターの腹腔鏡下肝切除術における有用性

  土田 忍; 福本 巧; 楠 信也; 木戸 正浩; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 上野 公彦; 新関 亮; 外山 博近; 松本 逸平; 味木 徹夫; 濱口 武之; 具 英成

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 16 (7) 556 - 556 1344-6703 2011/12 [Refereed]
  
• 腹腔鏡補助下膵体尾部切除における困難症例の検討

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Ueno Kimihiko; Kito Masahiro; tsutida Shinobu; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌 16 (7号) 369  2011/12 [Refereed]
  
• 腹腔鏡下膵腫瘍核出術を施行したindeterminate mucin-producing cystic neoplasmの1例

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Toyama Hirochika; Kito Masahiro; tsutida Shinobu; Ueno Kimihiko; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌 16 (7号) 496  2011/12 [Refereed]
  
• 肝胆膵脾良性疾患に対する内視鏡外科の適応 腹腔鏡下膵切除術における適応と手技

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Ueno Kimihiko; tsutida Shinobu; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌 16 (7号) 185  2011/12 [Refereed]
  
• IPMNに対する腹腔鏡手術の適応

  Shinzeki Makoto; Matsumoto Ippei; Toyama Hirochika; Asari Sadaki; Kito Masahiro; tsutida Shinobu; Ueno Kimihiko; Ajiki Tetsuo; Fukumoto Takumi; Hori Yuichi; Ku Yonson

  日本内視鏡外科学会雑誌 16 (7号) 585  2011/12 [Refereed]
  
• A focal mass-forming autoimmune pancreatitis mimicking pancreatic cancer with obstruction of the main pancreatic duct.

  Ippei Matsumoto; Makoto Shinzeki; Hirochika Toyama; Sadaki Asari; Tadahiro Goto; Isamu Yamada; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract SPRINGER 15 (12) 2296 - 8 1091-255X 2011/12 [Refereed]
   

  INTRODUCTION AND BACKGROUND: Autoimmune pancreatitis (AIP) is a rare disease that closely mimics pancreatic cancer (PC) in its presentation. It is very important for clinicians to distinguish one from the other because their treatment and prognosis are vastly different. Typical radiological imaging findings, in particular observation of diffusely or segmentally narrowed main pancreatic duct (MPD) with an irregular wall by endoscopic retrograde cholangiopancreatography (ERCP), are essential for making the diagnosis of AIP. On the other hand, MPD obstruction is one of the most frequent features on ERCP. CASE REPORT: We report a rare case of a patient with focal mass-forming AIP strongly suspected of being PC because of MPD obstruction on ERCP. CONCLUSION: It was difficult to distinguish PC from AIP with current diagnostic modalities. We will continue to make an effort to distinguish between the two disorders to prevent unnecessary surgery.
• 肺癌肝転移の診断でRFAを施行した肝内胆管癌の1例

  Kusunoki Nobuya; Matsumoto Ippei; Ajiki Tetsuo

  癌と化学療法 (株)癌と化学療法社 38巻, 12号, pp. 2030-2032 (12) 2030 - 2032 0385-0684 2011/11 [Refereed]
   

  症例は43歳、男性。2008年12月健診で肺野に結節影を指摘され前医受診。CTで右肺上葉に上大静脈浸潤を伴う35mm大の腫瘤、および肝S7に32mm大の腫瘤を指摘された。肝腫瘤に対し生検を施行しadenocarcinomaと診断されたため、原発性肺癌、肝転移の診断で、2009年1月より全身化学療法を開始した。肝S7腫瘤に対し2月にラジオ波焼灼療法(RFA)、肺腫瘤に対し12月に放射線照射を施行。肺病変は著明に縮小したが、肝病変は10月に再発が確認された後、発育進展を続け8月には80mm大にまで増大した。肝病変に対する治療目的で当科紹介となり、10月に肝右葉、右横隔膜、右肺合併切除術を施行。病理組織診断、免疫染色にて肝内胆管癌と最終診断された。2011年1月現在多発残肝再発、腹膜転移、多発肺転移を認めている。肝内胆管癌に対する確立された治療は肝切除のみであり、RFAの是非については統一した見解が得られていない。多発癌に対しては慎重に臨床診断を行うべきであると考えられた。(著者抄録)
• [A case report of intrahepatic cholangiocarcinoma diagnosed as lung cancer with liver metastasis treated with radiofrequency ablation].

  Kenji Fukushima; Masahiro Kido; Takumi Fukumoto; Yuichi Hori; Nobuya Kusunoki; Shinobu Tsuchida; Masanori Takahashi; Motofumi Tanaka; Kaori Kuramitsu; Daisuke Tsugawa; Hidetoshi Gon; Masashi Chuma; Takeshi Urade; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku; Maki Kanzawa; Tomoo Ito

  Gan to kagaku ryoho. Cancer & chemotherapy 38 (12) 2030 - 2 0385-0684 2011/11 [Refereed]
   

  In December 2008, a 43-year-old male who had been pointed out a nodular shadow in the right upper field on a chest radiography was admitted to hospital. A 35 mm mass infiltrating to superior vena cava in the right upper lobe of the lung, and 32 mm mass in the liver at S7 were detected by CT. Pathological diagnosis of the liver tumor was adenocarcinoma. Under the diagnosis of lung carcinoma and liver metastasis, systemic chemotherapy was started from January 2009. Radiofrequency ablation (RFA) therapy was added for liver S7 mass in February, and radiation therapy was performed for lung mass in December. The lung lesion has markedly reduced, but the liver lesion recurred in October 2009, which continued to grow up to 80 mm until August 2010. He presented to our hospital with the diagnosis of liver metastasis of controlled primary lung cancer. In October, we performed right hepatectomy with diaphragma and right lung resection. The pathological diagnosis was intrahepatic cholangiocarcinoma. Multiple recurrences in remnant liver, lung and peritoneal metastasis were detected in January 2011. For intrahepatic cholangiocarcinoma, hepatectomy is the only established treatment, and RFA treatment remains controversial. Clinical diagnosis of multiple cancers should be decided with caution.
• [A case report of multiple advanced hepatocellular carcinomas treated by combination therapy with hepatectomy and particle therapy].

  Takeshi Urade; Masahiro Kido; Takumi Fukumoto; Yuichi Hori; Nobuya Kusunoki; Shinobu Tsuchida; Masanori Takahashi; Motofumi Tanaka; Kaori Kuramitsu; Daisuke Tsugawa; Hidetoshi Gon; Masashi Chuma; Kenji Fukushima; Ippei Matsumoto; Tetsuo Ajiki; Kazuki Terashima; Yusuke Demizu; Masao Murakami; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 38 (12) 2065 - 7 0385-0684 2011/11 [Refereed]
   

  We report a case of multiple advanced hepatocellular carcinomas (HCC) with bilobar distribution treated by combination therapy of hepatectomy and particle therapy (carbon ion therapy). A 73-year-old man who had been pointed out hepatic tumors on abdominal CT was referred to our hospital in February 2010. Advanced HCCs; 8 cm Vp3 and 6 cm in the left lobe, 4 cm in the posterior segment, and 1 .5 cm in the S8 area, were detected by abdominal dynamic CT and EOB-MRI etc. Curative resection was not applied due to insufficiency of liver function and unfavorable anatomical tumor locations. Accordingly we have developed a novel combination therapy of hepatectomy and particle therapy. First we performed left lobectomy in March 2010, followed by administration of particle therapy to the posterior segment for local control in May. Then, transcatheter arterial chemoembolization was administered 4 times for residual tumors. The patient survives for 15 months after the initial therapy with good local control.
• 神経内分泌腫瘍肝転移に対する肝切除の意義

  福島 健司; 木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 土田 忍; 高橋 応典; 蔵満 薫; 津川 大介; 権 英寿; 中馬 正志; 松本 逸平; 味木 徹夫; 新関 亮; 外山 博近; 上野 公彦; 具 英成

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 44 (Suppl.2) 306 - 306 0386-9768 2011/10
• 進行肝細胞癌の治療戦略 高度脈管浸潤を伴う進行肝癌に対する治療戦略

  木戸 正浩; 福本 巧; 楠 信也; 土田 忍; 高橋 応典; 蔵満 薫; 田中 基文; 福島 健司; 浦出 剛史; 味木 徹夫; 松本 逸平; 新関 亮; 外山 博近; 上野 公彦; 具 英成

  日本臨床外科学会雑誌 日本臨床外科学会 72 (増刊) 328 - 328 1345-2843 2011/10 [Refereed]
  
• 肉腫様変化を伴う肝内胆管癌の一切除例

  布施 知佐香; 後藤 直大; 木戸 正浩; 外山 博近; 田中 基文; 高橋 応典; 松本 逸平; 土田 忍; 楠 信也; 味木 徹夫; 新関 亮; 上野 公彦; 堀 祐一; 福本 巧; 具 英成

  日本臨床外科学会雑誌 日本臨床外科学会 72 (増刊) 619 - 619 1345-2843 2011/10 [Refereed]
  
• 小腸転移により出血性の持続的な貧血を認めた肝細胞癌の1例

  田井 謙太郎; 具 英成; 福本 巧; 木戸 正浩; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 中馬 正志; 浦出 剛史; 堀 裕一; 味木 徹夫; 楠 信也; 松本 逸平

  日本臨床外科学会雑誌 日本臨床外科学会 72 (増刊) 621 - 621 1345-2843 2011/10 [Refereed]
  
• 診断までに4年間の経過を追えた胆嚢癌の1切除例

  Matsumoto Ippei; Hara Shigeo

  日本臨床外科学会雑誌 72巻, 増刊, pp. 898-898 2011/10 [Refereed]
  
• 術前化学放射線療法のリンパ節転移に対する制御能とその評価

  Nakamura Tetsu; Matsumoto Ippei; Kuroda Daisuke

  日本大腸肛門病学会雑誌 (一社)日本大腸肛門病学会 64 (8) 555 - 555 0047-1801 2011/08 [Refereed]
  
• 高度脈管侵襲を伴う肝細胞癌に対する治療戦略 高度脈管侵襲を伴う肝細胞癌に対する神戸二段階療法を機軸とする集学的治療

  木戸 正浩; 福本 巧; 楠 信也; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 堀 裕一; 松本 逸平; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 66回 199 - 199 2011/07 [Refereed]
  
• 術前肝予備能評価の再考 Vp4門脈腫瘍栓を合併した肝細胞癌における術前肝予備能評価の再考

  楠 信也; 福本 巧; 土田 忍; 木戸 正浩; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 松本 逸平; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 66回 256 - 256 2011/07 [Refereed]
  
• 進行肝癌に対する治療戦略と手術の実際 両葉多発肝細胞癌に対する治療戦略 神戸二段階療法

  木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 味木 徹夫; 松本 逸平; 新関 亮; 外山 博近; 上野 公彦; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 23回 151 - 151 2011/06 [Refereed]
  
• 大腸癌肝転移における術前化学療法後の肝切除術

  楠 信也; 福本 巧; 土田 忍; 木戸 正浩; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 権 英寿; 中馬 正志; 松本 逸平; 味木 徹夫; 堀 裕一; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 23回 328 - 328 2011/06 [Refereed]
  
• 著明な肝外発育をきたした重量8kgを超える巨大肝細胞癌の一切除例

  田中 基文; 権 英寿; 木戸 正浩; 山田 勇; 土田 忍; 楠 信也; 高橋 応典; 蔵満 薫; 津川 大介; 中馬 正志; 松本 逸平; 味木 徹夫; 堀 裕一; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 23回 364 - 364 2011/06 [Refereed]
  
• 陽子線治療にてVp4門脈腫瘍栓を制御後、経皮的肝灌流化学療法(PIHP)を施行した1例

  土田 忍; 福本 巧; 楠 信也; 木戸 正浩; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 片岡 庸子; 権 英寿; 中馬 正志; 福島 健司; 外山 博近; 新関 亮; 松本 逸平; 上野 公彦; 山田 勇; 味木 徹夫; 堀 裕一; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集 (一社)日本肝胆膵外科学会 23回 365 - 365 2011/06 [Refereed]
  
• 石灰化を伴い腹部レントゲンで偶発的に発見された胆嚢内多発癌肉腫の1例

  Matsumoto Ippei; Kusunoki Nobuya; Hara Shigeo

  日本肝胆膵外科学会・学術集会プログラム・抄録集23回 巻, , pp. 457-457 2011/06 [Refereed]
  
• Percutaneous selective embolectomy using a Fogarty Thru-Lumen Catheter for pancreas graft thrombosis: a case report.

  Kenta Izaki; Masato Yamaguchi; Ippei Matsumoto; Makoto Shinzeki; Yonson Ku; Kazuro Sugimura; Koji Sugimoto

  Cardiovascular and interventional radiology 34 (3) 650 - 3 0174-1551 2011/06 [Refereed]
   

  A 57-year-old woman with a history of diabetes mellitus underwent simultaneous pancreas-kidney transplantation. The pancreaticoduodenal graft was implanted in the right iliac fossa. The donor's portal vein was anastomosed to the recipient's inferior vena cava (IVC). Seven days after the surgery, a thrombus was detected in the graft veins. Percutaneous thrombolysis was immediately performed; however, venous congestion was still present. We therefore attempted selective embolectomy using a Fogarty Thru-Lumen Catheter. Thrombi were directed from the graft veins toward the IVC and captured in the IVC filter with complete elimination of the thrombus without any major complications. We present our technique for the successful treatment of pancreas graft thrombosis within a short time period by percutaneous selective embolectomy using a Fogarty Thru-Lumen Catheter.
• 血管再建を伴う肝切除の手技上の工夫とその意義 肝切除における血管再建の是非

  木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 味木 徹夫; 松本 逸平; 津川 大介; 粟津 正英; 中馬 正志; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 112 (臨増1-2) 251 - 251 0301-4894 2011/05 [Refereed]
  
• 巨大腫瘍を伴う両葉多発高度進行肝癌に対する新戦略 術前・術後経皮的肝灌流化学療法(PIHP)併用3段階療法

  権 英寿; 木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 粟津 正英; 片岡 庸子; 中馬 正志; 味木 徹夫; 松本 逸平; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 112 (臨増1-2) 550 - 550 0301-4894 2011/05 [Refereed]
  
• 進行下部直腸癌に対する術前化学放射線療法における側方リンパ節郭清の意義

  Nakamura Tetsu; Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke

  日本外科学会雑誌 112巻, 臨増1-2, pp. 468-468 2011/05 [Refereed]
  
• [Two cases of localized autoimmune pancreatitis that relapsed after surgical treatment].

  Jun Inoue; Atsuhiro Masuda; Masaya Saito; Mitsuko Onoyama; Hideyuki Shiomi; Hirochika Toyama; Ryo Shinzeki; Ippei Matsumoto; Yoshitake Hayashi; Tetsuya Makino; Hidetoshi Tada; Hiromu Kutsumi; Yonson Ku; Takeshi Azuma

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 108 (4) 640 - 9 0446-6586 2011/04 [Refereed]
   

  Since the revision of Clinical Diagnostic Criteria for Autoimmune Pancreatitis (AIP) 2006, many cases of localized AIP have been reported. Localized AIP is often difficult to preoperatively differentiate from pancreatic carcinoma. We present two cases of localized AIP that developing relapse after surgical treatment. Swollen hilar lymph nodes of lung was detected on CT in both two cases. Recently, AIP is thought to be the pancreatic manifestation of an IgG4 related systemic disease, which has been associated with many extrapancreatic lesions. Response to steroid treatment and the detection of extrapancreatic lesions may contribute to provide adequate diagnosis thereby avoiding unnecessary surgery.
• 両葉多発肝細胞癌に対する治療戦略

  木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 味木 徹夫; 松本 逸平; 黒田 大介; 鈴木 知志; 具 英成

  日本消化器病学会雑誌 (一財)日本消化器病学会 108 (臨増総会) A235 - A235 0446-6586 2011/03 [Refereed]
  
• 初回肝切除術後の再発肝癌に対する治療戦略

  田中 基文; 福本 巧; 粟津 正英; 津川 大介; 楠 信也; 土田 忍; 木戸 正浩; 高橋 応典; 蔵満 薫; 中馬 正志; 松本 逸平; 味木 徹夫; 堀 裕一; 黒田 大介; 具 英成

  日本消化器病学会雑誌 (一財)日本消化器病学会 108 (臨増総会) A236 - A236 0446-6586 2011/03 [Refereed]
  
• 自己免疫性膵炎診断基準からみた膵癌との鑑別

  Fujita Tsuyoshi; Azuma Takeshi; Matsumoto Ippei

  日本消化器病学会雑誌 108巻, 臨増総会, pp. A215-A215 0446-6586 2011/03 [Refereed]
  
• Endoscopic sphincterotomy for lemmel syndrome presenting with severe acute pancreatitis: A case report

  Makoto Shinzeki; Yuichi Hori; Ippei Matsumoto; Sachiyo Shirakawa; Hideyo Mukubou; Hirochika Toyama; Tetsuo Ajiki; Takumi Fukumoto; Yonson Ku

  Japanese Journal of Gastroenterological Surgery Japanese Society of Gastroenterological Surgery 44 (2) 123 - 130 1348-9372 2011 [Refereed]
   

  Juxtapapillary duodenal diverticula (JPDD) is an etiologic factor in biliopancreatic disorder designated by Lemmel syndrome, which is reported to trigger cholangitis rather than acute pancreatitis. A 68-year-old woman with a history of relapsing cholangitis seen for acute nectrotizing pancreatitis was given intensive care. After her pancreatitis improved, she underwent gastrointestinal endoscopic study, which showed the papilla of Vater lying between two large JPDD. Assuming that JPDD played a causative role in both relapsing cholangitis and acute pancreatitis, we conducted endoscopic sphincterotomy. Neither condition has recurred in outpatient follow-up in 13 months since her discharge from the hospital. This is, to the best of our knowledge, the second case of Lemmel syndrome inducing severe acute ne-crotizing pancreatitis. Endoscopic sphincterotomy should be considered in symptomatic JPDD as a minimally invasive therapeutic approach to prevent biliopancreatic complications including cholangitis and acute pancreatitis. © 2011 The Japanese Society of Gastroenterological Surgery.
• Post-pancreaticoduodenectomy gastrointestinal tract conversion surgery for recurrent severe cholangitis

  Tadahiro Goto; Ippei Matsumoto; Makoto Shinzeki; Hirochika Toyama; Tetsuo Ajiki; Yonson Ku

  Japanese Journal of Gastroenterological Surgery Japanese Society of Gastroenterological Surgery 44 (1) 44 - 50 1348-9372 2011 [Refereed]
   

  A 64-year-old woman undergoing pancreaticoduodenectomy (PD-IIIa, Imanaga reconstruction) for pancreatic adenoma at age 48 and suffering recurring cholangitis from 8 years postoperatively, had repeated cholangitis-induced septic shock from 1998, for which she was admitted in May 2006. Endoscopic retrograde cholangiography (ERC) showed food regurgitation at the hepatodochojejunostomy but no anastomotic stricture. An endoscopic retrograde biliary drainage (ERBD) tube was temporarily effective, but cholangitis recurred with obstruction or tube removal. Exploratory surgery showed anal-side jejunal adhesion of the hepatochojejunostomy. We converted to PD-II and exfoliated the adhesions. The woman has been cholangitis-free and well in the 36 months since surgery. Aggressive surgery should be considered if conservative post-pancreaticoduodenectomy treatment does not control cholangitis. © 2011 The Japanese Society of Gastroenterological Surgery.
• [Mucinous cystic neoplasm of the pancreas associated with pregnancy: report of two cases].

  Sachiyo Shirakawa; Ippei Matsumoto; Syunji Nakayama; Hideyo Mukubo; Hirochika Toyama; Makoto Shinzeki; Takumi Fukumoto; Tetsuo Ajiki; Yonson Ku

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 107 (11) 1828 - 34 0446-6586 2010/11 [Refereed]
   

  Pancreatic neoplasms during pregnancy are rare. We describe two cases of mucinous cystic neoplasm (MCN) associated with pregnancy. A 34-year-old woman in the 26th week of pregnancy was given a diagnosis of MCN measuring 19 cm in diameter. We decided to resect it post partum in consideration of the risk of abortion. She had a healthy infant in the 40th week of pregnancy and three months later, distal pancreatectomy was performed. Pathological analysis revealed a mucinous cystadenoma of the pancreas. The second case was a 36-year-old woman. She was given a diagnosis of MCN, measuring 16 cm in diameter, post partum and distal pancreatectomy was performed. Pathologically, the tumor was an invasive mucinous cystadenocarcinoma of the pancreas. In this report, we did an extensive literature review and discussed the management of MCN during pregnancy with special reference to the timing of the operation and the relationship between tumor growth and sex hormones.
• [A case of Vp4 portal vein tumor thrombosis--a complete remission achieved with dual treatment of surgery plus percutaneous isolated hepatic perfusion].

  Masashi Chuma; Takumi Fukumoto; Nobuya Kusunoki; Shinobu Tsuchida; Masahiro Kido; Masanori Takahashi; Daisuke Tsugawa; Masahide Awazu; Yoko Kataoka; Ippei Matsumoto; Yuichi Hori; Daisuke Kuroda; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 37 (12) 2300 - 2 0385-0684 2010/11 [Refereed]
   

  We herein report a case of advanced hepatocellular carcinoma (HCC) with Vp4 portal vein thrombosis (PVTT). All of the hepatic tumors have completely disappeared for more than two years by a dual treatment with reductive surgery plus percutaneous isolated hepatic perfusion (PIHP). A 68-year-old man was referred to our institution in May 2009. The abdominal CT scan demonstrated massive HCC in the right robe of the liver with PVTT reaching the portal trunk (Vp4). We semi-electively performed a right hepatectomy together with thrombectomy of the PVTT. Subsequently, we underwent a PIHP (doxorubicin 90 mg/m2). This resulted in normalization of serum AFP and PIVKA-II levels. Dual treatment is considered to be the strongest therapeutic modality for multiple advanced HCC with severe PVTT.
• [A long-term survival case of postoperative lymph node metastases from hepatocellular carcinoma treated with lymph node dissection and percutaneous isolated hepatic perfusion (PIHP)].

  Daisuke Tsugawa; Takumi Fukumoto; Nobuya Kusunoki; Shinobu Tsuchida; Hiroyoshi Sendo; Masahiro Kido; Masanori Takahashi; Atsushi Takebe; Masahide Awazu; Yoko Kataoka; Ippei Matsumoto; Tetsuo Ajiki; Yuichi Hori; Satoshi Suzuki; Daisuke Kuroda; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy 37 (12) 2312 - 4 0385-0684 2010/11 [Refereed]
   

  We report a long-term survival case of hepatocellular carcinoma (HCC) with recurrence in the liver and multiple lymph nodes treated with lymph node dissection and percutaneous isolated hepatic perfusion (PIHP). The patient was a 70-year-old man with HCC. In 1999, transcatheter arterial chemoembolozation (TACE) was performed for HCCs. In 2000, partial hepatectomy was achieved for a recurrence in the liver. In 2002, CT scan disclosed multiple lymph node metastases around the hepatic artery and the recurrence in the liver. We performed a lymph node dissection and radio-frequency ablation for the hepatic tumor. After the operation, PIHP was performed for residual lymph node metastases. Then, a recurrence in the liver occurred 3 times, but was treated successfully with local therapy. The patient survives for 10 years after the initial therapy, and 8 years after a lymph node dissection.
• [Particle beam radiotherapy with a surgical spacer placement for unresectable sacral chordoma].

  Masanori Takahashi; Takumi Fukumoto; Nobuya Kusunoki; Shinobu Tsuchida; Masahiro Kido; Atsushi Takebe; Masahide Awazu; Yoko Kataoka; Ippei Matsumoto; Tetsuo Miki; Yuichi Hori; Satoshi Suzuki; Daisuke Kuroda; Masao Murakami; Yoshio Hishikawa; Yonson Ku

  Gan to kagaku ryoho. Cancer & chemotherapy Japanese Journal of Cancer and Chemotherapy Publishers Inc. 37 (12) 2804 - 6 0385-0684 2010/11 [Refereed]
   

  Sacral chordomas constitute more than half of all chordomas and have a slower local growth than other bone malignant tumors. Although complete radical resection produces a longer local control and disease-free survival at the initial visit, chordomas are already often too large for complete resection to be possible. Particle radiotherapy consisting of proton and carbon-ion is a promising new modality which has an inherent anti-tumor effect against many types of malignancies. However, the application of particle radiotherapy for tumors adjacent to the gastrointestinal tract like sacral chordoma is restricted because the tolerance dose of the intestine is extremely low. A novel two-step treatment was developed with surgical spacer placement and subsequent proton radiotherapy to administer particle radiotherapy with curative intent. This report presents a case of a patient with a huge sacral chordoma treated by this method. This new strategy may potentially be an innovative and standard therapy for unresectable sacral chordoma in the near future.
• 巨大肝細胞癌に対する切除成績の検討

  津川 大介; 福本 巧; 楠 信也; 千堂 宏義; 木戸 正浩; 高橋 応典; 武部 敦志; 小松 昇平; 片岡 庸子; 松本 逸平; 味木 徹夫; 堀 裕一; 高瀬 至郎; 黒田 大介; 具 英成

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 43 (Suppl.2) 311 - 311 0386-9768 2010/10
• 大腸癌内視鏡治療穿孔症例に対する腹腔鏡下手術

  Matsumoto Ippei; Hori Yuichi; Morita Yoshinori; Ku Yonson; Kuroda Daisuke

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 15 (7) 617 - 617 1344-6703 2010/10
• 先天性胆道拡張症に対する総胆管嚢腫切除12年後に発生、切除した肝門部胆管癌の1例

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本臨床外科学会雑誌 71巻, 増刊, pp. 698-698 2010/10 [Refereed]
  
• 膵頭十二指腸切除における術後合併症とその対策 膵頭十二指腸切除術後出血症例の検討

  Matsumoto Ippei; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本臨床外科学会雑誌 日本臨床外科学会 71巻, 増刊, pp. 372-372 (増刊) 372 - 372 1345-2843 2010/10 [Refereed]
  
• 腹腔鏡下胆嚢摘出術における術中胆道造影についての検討

  Matsumoto Ippei; Kuroda Daisuke; Kusunoki Nobuya; Ku Yonson

  日本内視鏡外科学会雑誌 15巻, 7号, pp. 483-483 2010/10 [Refereed]
  
• 当科における腹腔鏡下胃全摘術の食道空腸吻合法の変遷と標準化への工夫

  Matsumoto Ippei; Hori Yuichi; Ku Yonson; Kuroda Daisuke

  日本内視鏡外科学会雑誌 15巻, 7号, pp. 463-463 2010/10 [Refereed]
  
• 大腸癌内視鏡治療後の追加治療における、腹腔鏡補助下手術の有用性

  Matsumoto Ippei; Hori Yuichi; Ku Yonson; Kuroda Daisuke

  日本内視鏡外科学会雑誌 15巻, 7号, pp. 605-605 2010/10
• 早期胃癌に対するESD後の追加手術としての腹腔鏡下胃切除術の検討

  Matsumoto Ippei; Hori Yuichi; Ku Yonson; Kuroda Daisuke

  日本臨床外科学会雑誌 71巻, 増刊, pp. 513-513 2010/10 [Refereed]
  
• 最善の肝切除を目指した基本技術と新しい工夫 Back flow perfusion法を用いた門脈腫瘍栓合併肝癌に対する肝切除

  Hori Yuichi; Kusunoki Nobuya; Matsumoto Ippei; Kuroda Daisuke; Ku Yonson

  日本臨床外科学会雑誌 71巻, 増刊, pp. 340-340 2010/10 [Refereed]
  
• 局所進行切除不能膵癌に対する粒子線治療

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本臨床外科学会雑誌 71巻, 増刊, pp. 539-539 2010/10 [Refereed]
  
• 胸腔鏡下食道切除術 縦隔リンパ節郭清のコツ 神経および血管温存に留意した食道癌に対する胸腔鏡下縦隔リンパ節郭清

  Kuroda Daisuke; Matsumoto Ippei; Hori Yuichi; Ku Yonson

  日本内視鏡外科学会雑誌 15巻, 7号, pp. 283-283 2010/10 [Refereed]
  
• 外科におけるバーチャル画像の有用性と限界 肝門部・上部胆管癌の術前診断における胆管直接造影下3D-CTの有用性と限界

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Ku Yonson

  日本臨床外科学会雑誌 71巻, 増刊, pp. 382-382 2010/10 [Refereed]
  
• ss胆嚢癌切除症例の臨床的検討

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Ku Yonson

  日本臨床外科学会雑誌 71巻, 増刊, pp. 537-537 2010/10 [Refereed]
  
• Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas.

  Takuya Mimura; Atsuhiro Masuda; Ippei Matsumoto; Hideyuki Shiomi; Shiei Yoshida; Maki Sugimoto; Tsuyoshi Sanuki; Masaru Yoshida; Tsuyoshi Fujita; Hiromu Kutsumi; Yonsou Ku; Takeshi Azuma

  Journal of clinical gastroenterology LIPPINCOTT WILLIAMS & WILKINS 44 (9) e224-9 - E229 0192-0790 2010/10 [Refereed]
   

  GOALS: The predictors of malignant intraductal papillary mucinous neoplasm (IPMN) and invasive IPMN were investigated in this study to determine the optimal indicators of surgical resection for IPMN. BACKGROUND: Recently, international consensus guidelines have described the standard indicators of resection for IPMN. However, the indicators of surgical resection for IPMN, especially for branch duct IPMN, still remain controversial. STUDY: Eighty-two patients with IPMN who underwent surgical resection during April 1998 to January 2009, were retrospectively reviewed and examined with regard to their preoperative factors and pathologic diagnosis. RESULTS: Multivariate analysis showed that main duct IPMN (P<0.01) and earlier diabetes (P=0.03) were independent predictors of malignant IPMN. In branch duct IPMN, the diameter of the main pancreatic duct (MPD) was found to be significantly associated with malignancy by univariate analysis (P=0.034). An elevated serum CA19-9 level (P<0.01) was an independent predictor of invasive IPMN. CONCLUSIONS: Our observations suggest that main duct IPMN, branch duct IPMN with MPD dilatation, and IPMN with an elevated serum CA19-9 level should be considered as indications for surgical resection.
• 術前粒子線治療後、膵頭十二指腸切除術を施行した膵癌の1例

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本癌治療学会誌 45巻, 2号, pp. 672-672 2010/09 [Refereed]
  
• 骨転移を伴う肝細胞癌に対し、集学的治療を施行し長期生存を得た1例

  Hori Yuichi; Kusunoki Nobuya; Matsumoto Ippei; Kuroda Daisuke; Ku Yonson

  肝臓 51巻, Suppl.2, pp. A574-A574 2010/09 [Refereed]
  
• 局所進行切除不能膵癌に対する粒子線治療を用いた新たな試み

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本癌治療学会誌 45巻, 2号, pp. 730-730 2010/09 [Refereed]
  
• 肝胆膵領域がんに対する鏡視下手術の適応・限界 胸腔鏡下肝腫瘍ラジオ波焼灼術の適応・限界

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本癌治療学会誌 45巻, 2号, pp. 389-389 2010/09 [Refereed]
  
• 外科治療成績からみた非B非C型肝癌の現状と問題点

  Kusunoki Nobuya; Matsumoto Ippei; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  肝臓 51巻, Suppl.2, pp. A627-A627 2010/09 [Refereed]
  
• Gemcitabine投与により画像上肝転移が消失し、切除を行った膵・胆管合流異常合併胆嚢癌の1例

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Ku Yonson

  日本膵・胆管合流異常研究会プロシーディングス 33巻, , pp. 68-68 2010/09 [Refereed]
  
• 両葉多発肝細胞癌に対する神戸二段階療法 減量肝切除+経皮的肝灌流化学療法(Dual treatment of reductive surgery & percutaneous isolated hepatic perfusion for multiple hepatocellular carcinoma)

  木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 土田 忍; 味木 徹夫; 松本 逸平; 新関 亮; 外山 博近; 黒田 大介; 鈴木 知志; 高橋 応典; 具 英成

  日本癌学会総会記事 日本癌学会 69回 446 - 446 0546-0476 2010/08
• 肝細胞癌における門脈腫瘍栓進展速度の解析(Growing rate of portal vein tumor thrombus in patients with hepatocellular carcinoma)

  楠 信也; 福本 巧; 土田 忍; 木戸 正浩; 高橋 応典; 津川 大介; 粟津 正英; 松本 逸平; 味木 徹夫; 堀 裕一; 鈴木 知志; 黒田 大介; 具 英成

  日本癌学会総会記事 日本癌学会 69回 447 - 447 0546-0476 2010/08
• 粒子線を用いた局所進行切除不能膵癌に対する治療の試み(Particle radiotherapy with a surgical spacer placement for unresectable locally advanced pancreatic cancer)

  後藤 直大; 松本 逸平; 外山 博近; 新関 亮; 白川 幸代; 浅利 貞毅; 黒田 大介; 福本 巧; 堀 裕一; 村上 昌雄; 菱川 良夫; 具 英成

  日本癌学会総会記事 日本癌学会 69回 451 - 451 0546-0476 2010/08
• 癌幹細胞の関与からみた膵管癌と膵管内粘液性腫瘍の分子病理学的鑑別(CD133 expression distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas)

  堀 裕一; 具 英成; 清水 一也; 味木 徹夫; 福本 巧; 松本 逸平; 楠 信也; 木戸 正浩

  日本癌学会総会記事 日本癌学会 69回 514 - 514 0546-0476 2010/08
• 肝内結石精査中に発見され切除したIPNBの一例

  Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  胆道 24巻, 3号, pp. 431-431 2010/08 [Refereed]
  
• 過誤腫と思われた膵頭部腫瘤の一例

  Matsumoto Ippei; Ku Yonson; Kawakami Fumi; Azuma Takeshi

  日本医学放射線学会秋季臨床大会抄録集 (公社)日本医学放射線学会 巻, 46回, pp. S512-S512 S512 - S512 0048-0428 2010/08 [Refereed]
  
• Effect of oxygenated perfluorocarbon on isolated islets during transportation.

  Sachio Terai; Toshiaki Tsujimura; Shiri Li; Yuichi Hori; Hirochika Toyama; Makoto Shinzeki; Ippei Matsumoto; Yoshikazu Kuroda; Yonson Ku

  The Journal of surgical research ACADEMIC PRESS INC ELSEVIER SCIENCE 162 (2) 284 - 9 0022-4804 2010/08 [Refereed]
   

  BACKGROUND: Previous studies demonstrated the efficacy of the two-layer method (TLM) using oxygenated perfluorochemicals (PFC) for pancreas preservation. The current study investigated the effect of oxygenated PFC on isolated islets during transportation. MATERIALS AND METHODS: Purified rat islets were stored in an airtight conical tube for 24h in RPMI culture medium at 22 degrees C or University of Wisconsin solution (UW) at 4 degrees C, either with or without oxygenated PFC. After storage, the islets were assessed for in vitro viability by static incubation (SI), FDA/PI staining, and energy status (ATP, energy charge, and ADP/ATP ratio) and for in vivo viability by a transplantation study. RESULTS: UW at 4 degrees C and RPMI medium at 22 degrees C maintained islet quality almost equally in both in vitro and in vivo assessments. The ATP levels and energy status in the groups with PFC were significantly lower than those without PFC. The groups with PFC showed a significantly higher ADP/ATP ratio than those without PFC. In the transplantation study, blood glucose levels and AUC in the UW+PFC group were significantly higher than those in UW group. CONCLUSIONS: UW at 4 degrees C and RPMI medium at 22 degrees C maintained islet quality equally under the conditions for islet transportation. The addition of oxygenated PFC, while advantageous for pancreas preservation, is not useful for islet transportation.
• 10cm以上の肝細胞癌における減量肝切除の意義

  津川 大介; 福本 巧; 楠 信也; 木戸 正浩; 松本 逸平; 味木 徹夫; 堀 裕一; 神垣 隆; 黒田 大介; 具 英成

  日本消化器外科学会総会 (一社)日本消化器外科学会 65回 134 - 134 2010/07 [Refereed]
  
• 膵頭十二指腸切除術における安全、確実な膵・空腸吻合手術手技

  Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 (一社)日本肝胆膵外科学会 22回 187 - 187 2010/05 [Refereed]
  
• 膵胆道癌手術と化学療法・化学放射線療法の接点 Gemcitabineを中心とした化学療法と外科切除のcombinationを利用した進行胆道癌の治療戦略

  Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 208-208 2010/05 [Refereed]
  
• 膵癌に対する門脈合併切除の手術手技と成績

  Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 177-177 2010/05 [Refereed]
  
• 門脈、胆管浸潤を伴ったG-CSF産生肝細胞癌に対する治療経過

  Hori Yuichi; Kusunoki Nobuya; Matsumoto Ippei; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 299-299 2010/05 [Refereed]
  
• 当科における急性胆嚢炎に対する腹腔鏡下胆嚢摘出術

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 425-425 2010/05 [Refereed]
  
• 当院における腹腔鏡下尾側膵切除術の検討

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 199-199 2010/05 [Refereed]
  
• 当院における巨大肝細胞癌に対する切除成績の検討

  Kusunoki Nobuya; Matsumoto Ippei; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 194-194 2010/05 [Refereed]
  
• 胆嚢管が肝後区域枝から分岐する型にMirizzi症候群を伴った胆嚢結石症の1例

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 319-319 2010/05 [Refereed]
  
• 大腸癌肝転移に対する肝切除における術前化学療法の安全性

  Kusunoki Nobuya; Matsumoto Ippei; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 453-453 2010/05 [Refereed]
  
• 早期膵癌の切除経験 当院におけるStage I膵癌5例の検討

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 227-227 2010/05 [Refereed]
  
• IPMN精査中に診断されたStage I浸潤性膵管癌の1例

  Matsumoto Ippei; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集22回 巻, , pp. 427-427 2010/05
• Mucinous cystic neoplasm of the pancreas presenting with hemosuccus pancreaticus: report of a case.

  Makoto Shinzeki; Yuichi Hori; Yasuhiro Fujino; Ippei Matsumoto; Hirochika Toyama; Toshiaki Tsujimura; Tetsuya Sakai; Tetsuo Ajiki; Yoshikazu Kuroda; Yonson Ku

  Surgery today SPRINGER 40 (5) 470 - 3 0941-1291 2010/05 [Refereed]
   

  Hemosuccus pancreaticus (HP) is mostly induced by a ruptured pseudoaneurysm or hemorrhage from a pseudocyst in chronic pancreatitis. We herein report a rare case with HP induced by tumor hemorrhage. The present patient is a 71-year-old woman referred to us with a diagnosis of severe progressive anemia. Endoscopy revealed hemorrhage from the papilla of Vater. Computed tomography showed a multilocular cystic tumor in the tail of the pancreas. The patient underwent a distal pancreatectomy. The histopathological diagnosis was carcinoma in mucinous cystadenoma. No cancer infiltration into the pancreatic duct was detected. Pancreatography of the resected specimen demonstrated an overt communication between the main pancreatic duct and the cystic cavity of the tumor, which was not demonstrated preoperatively by endoscopic retrograde pancreatography. Although the cause of HP is mainly acute or chronic pancreatitis, we should bear in mind that a pancreatic tumor may be a possible cause of HP and that, as such, prompt and proper treatment is mandatory.
• 門脈腫瘍栓を合併した進行肝細胞癌に対する術前肝機能評価の検討

  Kusunoki Nobuya; Matsumoto Ippei; Hori Yuichi; Ku Yonson

  肝臓 51巻, Suppl.1, pp. A186-A186 2010/04 [Refereed]
  
• 胆嚢癌卵巣転移の1例

  Ajiki Tetsuo; Matsumoto Ippei; Ku Yonson

  日本消化器外科学会雑誌 The Japanese Society of Gastroenterological Surgery 43巻, 4号, pp. 411-416 (4) 411 - 416 0386-9768 2010/04 [Refereed]
   

  A 49-year-old woman seen for elevated liver blood chemistry, CA19-9 and computed tomography (CT) gallbladder findings, and ovarian tumors was found to have diffuse gallbladder wall thickening with papillary growth. Magnetic resonance imaging (MRI) showed a mild low-intensity mass 14cm in diameter with multiple cysts in the pelvic cavity, necessitating laparotomy based on a diagnosis of double cancer of the gallbladder and ovary. Curative resection was abandoned due to peritoneal gallbladder cancer dissemination, with pathological resection of the ovarian tumor and regional gallbladder lymph node sampling alone done, but which showed ovarian tumor and lymph node metastasis as metastatic gallbladder adenocarcinoma. Immunohistochemical staining confirmed similar overexpression of CA19-9, cytokeratin7, cytokeratin20, and p53 in both specimens. Metastatic ovarian tumors frequently derive from gastrointestinal cancer, but gallbladder cancer with ovarian metastasis is very rare.
• 肝細胞癌の大腸転移の2例

  中馬 正志; 木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 千堂 宏義; 味木 徹夫; 松本 逸平; 黒田 大介; 神垣 隆; 伊藤 智雄; 具 英成

  日本消化器病学会雑誌 (一財)日本消化器病学会 107 (臨増総会) A365 - A365 0446-6586 2010/03 [Refereed]
  
• 診断に苦慮した膵solid-pseudopapillary neoplasmの1例

  白川 幸代; 松本 逸平; 新関 亮; 外山 博近; 平田 建郎; 木戸 正浩; 上野 公彦; 山田 勇; 楠 信也; 福本 巧; 神垣 隆; 黒田 大介; 味木 徹夫; 伊藤 智雄; 具 英成

  日本消化器病学会雑誌 (一財)日本消化器病学会 107 (臨増総会) A375 - A375 0446-6586 2010/03 [Refereed]
  
• 胆道癌におけるFDG-PETの意義と問題点

  山田 勇; 味木 徹夫; 上野 公彦; 平田 建郎; 大坪 出; 新関 亮; 外山 博近; 松本 逸平; 木戸 正浩; 楠 信也; 神垣 隆; 黒田 大介; 堀 裕一; 福本 巧; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 111 (臨増2) 220 - 220 0301-4894 2010/03 [Refereed]
  
• 腹腔鏡下膵体尾部切除術におけるHALSの有用性

  新関 亮; 松本 逸平; 外山 博近; 白川 幸代; 椋棒 英世; 平田 建郎; 上野 公彦; 楠 信也; 山田 勇; 味木 徹夫; 神垣 隆; 福本 巧; 黒田 大介; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 111 (臨増2) 277 - 277 0301-4894 2010/03 [Refereed]
  
• 癌幹細胞の関与からみた膵管癌とIPMNの臨床病理学的鑑別診断

  堀 裕一; 福本 巧; 味木 徹夫; 楠 信也; 松本 逸平; 具 英成; 黒田 大介; 神垣 隆

  日本外科学会雑誌 (一社)日本外科学会 111 (臨増2) 370 - 370 0301-4894 2010/03 [Refereed]
  
• 肝細胞癌治療アルゴリズムへの新しい提案

  木戸 正浩; 福本 功; 堀 裕一; 味木 徹夫; 楠 信也; 松本 逸平; 千堂 宏義; 新関 亮; 外山 博近; 高橋 応典; 武部 敦志; 小松 昇平; 黒田 大介; 神垣 隆; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 111 (臨増2) 406 - 406 0301-4894 2010/03 [Refereed]
  
• 肝硬変症例に対する腹腔鏡下胆嚢摘出術の工夫とその成績

  味木 徹夫; 平田 建郎; 上野 公彦; 山田 勇; 大坪 出; 松本 逸平; 新関 亮; 外山 博近; 楠 信也; 神垣 隆; 黒田 大介; 堀 裕一; 福本 巧; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 111 (臨増2) 414 - 414 0301-4894 2010/03 [Refereed]
  
• 臨床研修医制度の中でいかにして外科医を獲得し、育てるか 大学病院の役割と使命

  千堂 宏義; 木戸 正浩; 福本 巧; 堀 裕一; 味木 徹夫; 松本 逸平; 新関 亮; 外山 博近; 黒田 大介; 神垣 隆; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 111 (臨増2) 643 - 643 0301-4894 2010/03 [Refereed]
  
• 膵頭十二指腸切除術におけるISGPF基準による膵液瘻の評価

  白川 幸代; 松本 逸平; 外山 博近; 新関 亮; 椋棒 英世; 上野 公彦; 山田 勇; 木戸 正浩; 楠 信也; 神垣 隆; 黒田 大介; 堀 裕一; 福本 巧; 味木 徹夫; 具 英成

  日本外科学会雑誌 (一社)日本外科学会 111 (臨増2) 705 - 705 0301-4894 2010/03 [Refereed]
  
• 膵内分泌腫瘍に対する外科治療を軸とした治療戦略

  Matsumoto Ippei; Kusunoki Nobuya; Hori Yuichi; Ku Yonson

  日本外科学会雑誌 111巻, 臨増2, pp. 486-486 2010/03 [Refereed]
  
• 術中胆道造影時の胆汁膵管逆流現象の意義についての検討

  Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本外科学会雑誌 111巻, 臨増2, pp. 412-412 2010/03 [Refereed]
  
• 肝門部胆管癌疑いで切除した明らかな膵病変を伴わないIgG4関連硬化性胆管炎の1例

  Matsumoto Ippei; Kuroda Daisuke; Kusunoki Nobuya; Ku Yonson

  日本消化器病学会雑誌 107巻, 臨増総会, pp. A375-A375 2010/03
• 肝細胞癌治療における粒子線治療の位置づけ BCLC staging systemに基づいた治療成績の検討

  Kuroda Daisuke; Hori Yuichi; Kusunoki Nobuya; Matsumoto Ippei; Ku Yonson

  日本外科学会雑誌 111巻, 臨増2, pp. 221-221 2010/03 [Refereed]
  
• 外科切除からみた生活習慣病としての非ウイルス性肝細胞癌の治療成績

  Kusunoki Nobuya; Matsumoto Ippei; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本消化器病学会雑誌 107巻, 臨増総会, pp. A442-A442 2010/03 [Refereed]
  
• Vp4門脈腫瘍栓を合併した肝細胞癌における術前肝機能検査の再評価

  Kusunoki Nobuya; Matsumoto Ippei; Hori Yuichi; Kuroda Daisuke; Ku Yonson

  日本外科学会雑誌 111巻, 臨増2, pp. 730-730 2010/03 [Refereed]
  
• IPMN併存膵癌と浸潤性IPMNの鑑別に苦慮した1例

  Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke; Hori Yuichi; Ku Yonson

  日本消化器病学会雑誌 107巻, 臨増総会, pp. A371-A371 2010/03
• 術中心停止となり人工心肺(PCPS)下に手術施行し救命し得た急性胆嚢炎の1例

  平田 建郎; 味木 徹夫; 山田 勇; 上野 公彦; 大坪 出; 松本 逸平; 楠 信也; 神垣 隆; 黒田 大介; 坂本 敏仁; 松森 正術; 大北 裕; 具 英成

  日本腹部救急医学会雑誌 (一社)日本腹部救急医学会 30 (2) 250 - 250 1340-2242 2010/02 [Refereed]
  
• 胆道癌化学療法中の消化管閉塞に対するバイパス手術

  Matsumoto Ippei; Kusunoki Nobuya; Kuroda Daisuke; Ku Yonson

  日本腹部救急医学会雑誌 30巻, 2号, pp. 303-303 2010/02
• Clinical Reappraisal of Total Pancreatectomy for Pancreatic Disease

  Yasuhireo Fujino; Ippei Matsumoto; Tetsuo Ajiki; Yoshikazu Kuroda

  HEPATO-GASTROENTEROLOGY H G E UPDATE MEDICAL PUBLISHING S A 56 (94-95) 1525 - 1528 0172-6390 2009/09 [Refereed]
   

  Background/Aims: In this study, it was reappraised the outcomes of total pancreatectomy (TP), retrospectively analyzing the safety of the procedures and factors associated with long-term survival. Methodology: Thirty-six consecutive patients underwent TP for pancreas disease at Kobe University Hospital. The outcomes of TP were evaluated, analyzing operation-related results (mortality, morbidity, survival and long-term outcomes) and oncological aspects. Results: Postoperative morbidity was 39% (14/36) and severe complications were anastomotic leak-age (n=3) and liver necrosis (n=1). In benign disease, 5-year survival was 50%, while 5-year survival in malignant disease was 22%. Postoperative glycosylated hemoglobin A1c (HbA1c) level was 7.8 +/- 1.2% at 6 months and 7.8 +/- 1.5% at 12 months after TP, respectively. Conclusion: TP is safely performed and the treatment option for selectively limited pancreatic cancer and intraductal papillary mucinous neoplasm of the pancreas (IPMN), when the patient condition permits and offers a chance of cure, although careful long-term medical care and follow-up are essential.
• 肝細胞癌に対する生体肝移植の適応と施行時期 肝細胞癌に対する生体肝移植の適応 1cm以下の小病変の算定意義について

  田中 基文; 福本 巧; 富永 正寛; 味木 徹夫; 楠 信也; 松本 逸平; 木戸 正浩; 尾形 哲; 具 英成

  移植 (一社)日本移植学会 44 (1) 102 - 102 0578-7947 2009/02 [Refereed]
  
• Effect of short-term culture on functional and stress-related parameters in isolated human islets.

  Sung-Hee Ihm; Ippei Matsumoto; Hui J Zhang; Jeffrey D Ansite; Bernhard J Hering

  Transplant international : official journal of the European Society for Organ Transplantation WILEY-BLACKWELL PUBLISHING, INC 22 (2) 207 - 16 0934-0874 2009/02 [Refereed]
   

  The Edmonton protocol for islet transplantation utilizes fresh islet grafts but other protocols increasingly transplant short-term cultured grafts mainly for practical reasons. To improve our understanding of the impact of culture pretreatment of human islets, we assessed post-transplant function by nude mouse bioassay, islet ATP, activity of stress-activated MAP kinases, and expression of stress-related genes by focused cDNA array in freshly isolated and cultured islets. Mean blood glucose levels over 4 weeks after transplantation (2000 IE) of (i) freshly isolated, (ii) cultured and preculture counted (recovery rate; 78 +/- 6%), and (iii) cultured and postculture counted islets in diabetic mice were 330 +/- 40, 277 +/- 65, and 256 +/- 52 mg/dl (i versus ii, P = 0.004; i versus iii, P = 0.002). During culture, islet ATP/DNA and ATP/ADP increased; JNK and p38 MAPK activities decreased. Among 96 genes studied, mRNA expression of heat shock protein 70 genes decreased >twofold during culture in all four pairs; expression of cyclooxygenase-2, superoxide dismutase-2, interleukin-6 and cytochromes P450 1A1 genes increased. Our results show that culturing human islets before transplantation is not disadvantageous in regard of functional recovery from changes induced by nonphysiologic stimuli during islet isolation. The increase in expression of several stress-related genes during culture also shows that improving culture conditions may further enhance post-transplant islet function.
• Impact of internal biliary drainage after pancreaticoduodenectomy.

  Yasuhiro Fujino; Ippei Matsumoto; Makoto Shinzeki; Tetsuo Ajiki; Yoshikazu Kuroda

  Journal of hepato-biliary-pancreatic surgery SPRINGER TOKYO 16 (2) 160 - 4 0944-1166 2009 [Refereed]
   

  BACKGROUND: Bile acid has an important role in protecting immune systems related to gut-associated lymphoid tissue. This study was designed to evaluate the effects of internal biliary drainage after a pancreaticoduodenectomy (PD) on postoperative nutrition and complications in a randomized study. METHODS: The authors compared the morbidity, mortality, and postoperative nutritional status of 46 patients who had a hepaticojejunostomy (HJ) with a stented external biliary drainage (group E) or with a non-stented internal biliary drainage (group I) after a PD. RESULTS: Systemic infection was recognized in four patients in group E, while no patients in group I. Transthyretin at postoperative 28 days in group I was 15.6 +/- 6.2, higher than that in group E. Retinol-binding protein at postoperative 28 days in group I was 2.6 +/- 1.0 and also higher than that in group E. CONCLUSION: HJ with no-stented internal biliary drainage was not associated with systemic infections and mortality, but showed the possibility of improving nutritional status.
• 肝細胞癌に対する生体肝移植の適応 1cm以下の小病変の算定意義について

  千堂 宏義; 福本 巧; 富永 正寛; 田中 基文; 味木 徹夫; 村松 三四郎; 楠 信也; 松本 逸平; 木戸 正浩; 尾形 哲; 具 英成

  日本臨床外科学会雑誌 日本臨床外科学会 69 (増刊) 286 - 286 1345-2843 2008/10 [Refereed]
  
• 当院で経験した膵管内乳頭粘液性腫瘍(IPMN)の他臓器癌の合併についての検討

  Morita Yoshinori; Seo Yasushi; Toyonaga Takashi; Ku Yonson; Azuma Takeshi

  日本消化器病学会雑誌 (一財)日本消化器病学会 105 (臨増大会) A899 - A899 0446-6586 2008/09
• Diagnostic and prognostic value of peritoneal cytology in biliary tract cancer

  Tetsuo Ajki; Tsunenori Fujita; Ippei Matsumoto; Taro Okazaki; Takeo Yasuda; Yasuhiro Fujino; Takashi Ueda; Yasuyuki Suzuki; Yoshikazu Kuroda; Yonson Ku

  HEPATO-GASTROENTEROLOGY H G E UPDATE MEDICAL PUBLISHING S A 55 (84) 842 - 845 0172-6390 2008/05 [Refereed]
   

  Background/Aims: Evaluation of peritoneal cytology provides valuable prognostic information in abdominal cancers. The aim of this study is to assess the incidence and the prognostic value of conventional peritoneal cytology in biliary tract cancers. Methodology: A total of consecutive 41 patients with biliary cancers (17 bile duct, 20 gallbladder, 4 ampulla of Vater) underwent surgery between July 2003 and July 2005. Peritoneal cytology was performed in these patients at the beginning of laparotomy. On opening the abdomen, 100mL of normal saline were instilled into the subhepatic space and retrieved. Cytologic analysis was performed using the Papanicolau technique. Results: The overall incidence of positive cytology findings was 9.8% (4/41). When analyzed by disease factors or stage, the prevalence of positive cytology was 0% in T1/T2, 6% in T3, 38% in T4 (p=0.03), 0% in NO, 25% in N1 (p=0.03), 3% in M0, 27% in M1 (p=0.02), 0% in Stage I/II and 27% in Stage III/IV cases (p<0.01), respectively. Although survival was worse in patients with positive peritoneal cytology, when adjusting TNM stage the positive peritoneal cytology did not have significant prognostic value. Conclusions: Peritoneal cytology associates positively with advanced disease but does not increase prognostic information in biliary tract cancers.
• Histological features of lymph node metastasis in patients with biliary tract cancer.

  Haruki Morimoto; Tetsuo Ajiki; Takashi Ueda; Hidehiro Sawa; Tsunenori Fujita; Ippei Matsumoto; Takeo Yasuda; Yasuhiro Fujino; Yoshikazu Kuroda; Yonson Ku

  Journal of surgical oncology WILEY-LISS 97 (5) 423 - 7 0022-4790 2008/04 [Refereed]
   

  BACKGROUND AND OBJECTIVES: The presence of lymph node (LN) metastases is an important prognostic factor in patients with biliary cancers. The aim of this study was to characterize systematically the morphological features of metastatic LNs in biliary cancers. METHODS: Four hundred ninety-six LNs (including 112 para-aortic LNs) dissected from 47 patients with biliary cancer were examined. The diameter of the long axis (size) and the percent metastatic area relative to whole-node area were measured from histologic specimens. RESULTS: The average size of metastatic LNs (9.5 mm) was significantly larger than those without metastasis (6.5 mm; P < 0.01). The optimum cut-off size for positive LNs was >7.5 mm, but the sensitivity of this predictor of metastasis was low (60.8%). In general, metastatic area correlated significantly with the size of metastatic LNs (P = 0.023). Para-aortic LNs contained metastasis in 7.1% of cases, and only 25% of para-aortic LNs with a high ratio of metastatic area could be evaluated from preoperative CT scans. CONCLUSIONS: Although large LNs are highly suggestive of metastasis, poor detection of many small LNs with a low percentage of metastatic area can increase risk in patients with biliary tract cancer.
• Cronkhite-Canada syndrome presenting as recurrent severe acute pancreatitis.

  Takeo Yasuda; Takashi Ueda; Ippei Matsumoto; Daisuke Shirasaka; Takahiro Nakajima; Hidehiro Sawa; Makoto Shinzeki; Yongsik Kim; Yasuhiro Fujino; Yoshikazu Kuroda

  Gastrointestinal endoscopy MOSBY-ELSEVIER 67 (3) 570 - 2 0016-5107 2008/03 [Refereed]
  
• Prediction of early death in severe acute pancreatitis.

  Makoto Shinzeki; Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Naoki Matsumura; Hidehiro Sawa; Takahiro Nakajima; Ippei Matsumoto; Tsunenori Fujita; Tetsuo Ajiki; Yasuhiro Fujino; Yoshikazu Kuroda

  Journal of gastroenterology SPRINGER TOKYO 43 (2) 152 - 8 0944-1174 2008 [Refereed]
   

  BACKGROUND: In severe acute pancreatitis (SAP), it is clinically important at the time of admission to predict the likelihood of early death. This investigation aimed to clarify the factors predicting early death in SAP. METHODS: Early death was defined as death within 10 days after disease onset. Prediction factors for early death were evaluated from data obtained on admission from 93 patients with SAP, and the characteristics of patients who died early were analyzed. RESULTS: Between the early-death and early-survival groups, significant factors were base excess (BE), serum creatinine (Cr), blood sugar, serum glutamate oxaloacetic transaminase, and serum calcium. Multivariate analysis revealed that BE was an independent prediction factor for early death. The early-death rate in patients with BE < -5.5 mEq/l and Cr >or= 3.0 mg/dl was 31% and 36%, respectively. The combination of BE and Cr raised the positive predictive value to 50%, and was equally able to predict early death as the Japanese Severity Score (JSS), which was the most useful of the three conventional scoring systems used. All early-death patients had pancreatic necrosis, and their JSS was >or= 15 (stage 4). Characteristically, early-death patients had lactate dehydrogenase (LDH)>1300 IU/l, or they had serious preexisting comorbidities. CONCLUSIONS: As a single parameter, BE was most useful for predicting early death. The combination of BE and Cr could predict early death as well as the JSS. An extreme rise of LDH and serious preexisting comorbidity may also be risk factors for early death.
• Usefulness of performing a pancreaticojejunostomy with an internal stent after a pancreatoduodenectomy.

  Yasuhisa Kamoda; Yasuhiro Fujino; Ippei Matsumoto; Makoto Shinzeki; Tetsuya Sakai; Yoshikazu Kuroda

  Surgery today SPRINGER 38 (6) 524 - 8 0941-1291 2008 [Refereed]
   

  PURPOSE: In pancreaticojejunostomy (PJ), the occurrence of an injury during the removal of a stented tube is sometimes related to pancreatitis or late-onset stenosis of the pancreatic duct. In this study, we compare the outcomes of a PJ with an external stent versus an internal stent in a randomized study. METHODS: We compared the complications including pancreatic fistula, mortality, and postoperative hospital stay of 43 patients who had PJ with an external stent (group E) or PJ with an internal stent (group I) after a pancreaticoduodenectomy (PD). RESULTS: Pancreatic fistula occurred in 8 patients (36.4%) in group E, while it only was seen in 7 patients (33.3%) in group I. Pancreatitis was recognized in 3 patients in group E, while there was no patient in whom an obstruction due to an internal stent was suspected. CONCLUSION: Pancreaticojejunostomy with an internal stent is therefore considered to be an effective treatment alternative after PD, with an acceptable morbidity and no mortality.
• Resection of gallbladder cancer with hepatic metastasis after chemotherapy with gemcitabine.

  Haruki Morimoto; Tetsuo Ajiki; Shiro Takase; Tsunenori Fujita; Taku Matsumoto; Yoshiyasu Mita; Ippei Matsumoto; Yasuhiro Fujino; Yasuyuki Suzuki; Yoshikazu Kuroda; Yonson Ku

  Journal of hepato-biliary-pancreatic surgery SPRINGER TOKYO 15 (6) 655 - 8 0944-1166 2008 [Refereed]
   

  A 69-year-old man diagnosed as having gallbladder cancer with liver invasion and metastasis to Couinaud's hepatic segment 8 (S8) was referred to our hospital. Because of the presence of liver metastasis, gemcitabine administration was chosen. Although gemcitabine was effective for the liver metastasis, his serum carcinoembryonic antigen (CEA) level had gradually increased after 12 cycles of gemcitabine administration. There was no distant metastasis other than the liver metastasis (manageable with gemcitabine) on detailed radiological examination. Therefore, we performed surgery for the primary lesion, after obtaining informed consent. Pathological examination demonstrated viable cancer cells with necrosis and fibrosis in the gallbladder, and fibrosis without viable cancer cells in the induration in liver S8. Gemcitabine was re-administered as postoperative adjuvant chemotherapy. Twenty months after the surgery, there was no sign of recurrence. In selected patients, gemcitabine treatment may be effective against gallbladder cancer with metastasis.
• Serum immunosuppressive acidic protein levels in patients with severe acute pancreatitis.

  Makoto Shinzeki; Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Hidehiro Sawa; Takahiro Nakajima; Ippei Matsumoto; Tsunenori Fujita; Tetsuo Ajiki; Yasuhiro Fujino; Yoshikazu Kuroda

  Pancreas LIPPINCOTT WILLIAMS & WILKINS 35 (4) 327 - 33 0885-3177 2007/11 [Refereed]
   

  OBJECTIVES: In severe acute pancreatitis (SAP), immunologic impairment in the early phase may be linked to subsequent infectious complications. Immunosuppressive acidic protein (IAP) is an immunosuppressive factor to be present in serum and ascites of cancer patients, and it is used as a tumor marker and an index of immune status of cancer hosts. METHODS: We measured serum IAP levels in 42 patients with SAP (Japanese severity score [JSS] > or = 2) on admission and analyzed the relationships with disease severity, pancreatic necrosis, blood biochemical parameters on admission, and clinical outcome (infection and death). RESULTS: Serum IAP level increased 791 +/- 285 microg/mL (range, 159-1430 microg/mL) on admission and recognized abnormal high level (normal range, < 500 microg/mL) in 37 patients (88.1%). Serum IAP level was significantly lower in patients of stages 3 and 4 (JSS > or = 9) (678 +/- 187 microg/mL) than that in patients of stage 2 (2 < or = JSS < or = 8) (848 +/- 311 microg/mL). It was also significantly lower in patients whose Ranson score was 5 or higher (674 +/- 287 microg/mL) than that in patients whose Ranson score was 4 or less (910 +/- 287 microg/mL). Moreover, it was significantly lower in patients with pancreatic necrosis (693 +/- 194 microg/mL) than that in patients without pancreatic necrosis (922 +/- 336 microg/mL). Among the blood biochemical parameters on admission, serum IAP was significantly negatively correlated with hematocrit, serum lipase, and serum interferon gamma and was significantly positively correlated with serum total protein. Serum IAP levels in patients of stage 2 reached higher peak at 7 days after admission and decreased more rapidly than those in patients of stages 3 and 4. CONCLUSIONS: Serum IAP levels were elevated in patients with SAP but were significantly lower in patients with higher grade of severity or pancreatic necrosis. These results suggest that serum IAP levels may be related to systemic inflammatory response and reflect the immunoresponsiveness in patients with SAP.
• Lactate dehydrogenase-to-lymphocyte ratio for the prediction of infection in acute necrotizing pancreatitis.

  Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Makoto Shinzeki; Hidehiro Sawa; Takahiro Nakajima; Ippei Matsumoto; Tetsuo Ajiki; Yasuhiro Fujino; Yoshikazu Kuroda

  Pancreas LIPPINCOTT WILLIAMS & WILKINS 35 (4) 378 - 80 0885-3177 2007/11 [Refereed]
  
• Gemcitabine、S-1を基軸とした進行胆道癌に対する化学療法

  味木 徹夫; 藤田 恒憲; 神垣 隆; 高瀬 至郎; 松本 逸平; 新関 亮; 外山 博近; 森本 大樹; 松本 拓; 黒田 嘉和; 具 英成

  日本消化器病学会雑誌 (一財)日本消化器病学会 104 (臨増大会) A718 - A718 0446-6586 2007/09 [Refereed]
  
• Proposed new score predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas.

  Yasuhiro Fujino; Ippei Matsumoto; Takashi Ueda; Hirotika Toyama; Yoshikazu Kuroda

  American journal of surgery EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC 194 (3) 304 - 7 0002-9610 2007/09 [Refereed]
   

  BACKGROUND: Our objective was to predict malignancy for intraductal papillary mucinous neoplasms of the pancreas (IPMN) before operation. METHODS: Sixty-four resected patients with IPMN were examined and 17 parameters were investigated for their relation to malignancy by univariate and multivariate analysis. RESULTS: Multivariate logistic regression analysis showed that IPMN type, the size of main pancreatic duct, and serum carbohydrate antigen 19-9 were significant for malignancy. Size of the main pancreatic duct > or = 6.5 mm and serum carbohydrate antigen 19-9 > or = 35 U/mL scored 3 points, main duct type scored 2 points, and patulous papilla, jaundice, diabetes mellitus, and tumor size > or = 42 mm scored 1 point. When IPMNs with 3 and more than 3 points using the new score were diagnosed as malignant, accuracy was 90.6%. CONCLUSION: This scoring system for IPMN is feasible to detect malignancy and useful for selecting an appropriate treatment.
• Serum interleukin-15 level is a useful predictor of the complications and mortality in severe acute pancreatitis.

  Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Makoto Shinzeki; Hidehiro Sawa; Takahiro Nakajima; Kozo Takase; Ippei Matsumoto; Tsunenori Fujita; Tetsuo Ajiki; Yasuhiro Fujino; Yoshikazu Kuroda

  Surgery MOSBY-ELSEVIER 142 (3) 319 - 26 0039-6060 2007/09 [Refereed]
   

  BACKGROUND: In severe acute pancreatitis, multiple organ dysfunction syndrome and infectious complications are contributors to high mortality. Interleukin (IL)-15 is a novel cytokine that shares many biologic properties with IL-2. Serum IL-15 levels have not yet been determined in SAP. METHODS: Serum IL-15 concentrations were measured in 54 patients with severe acute pancreatitis on admission. The relationships with severity, organ dysfunction, infection, and prognosis were analyzed. Utility of IL-15 for the prediction of clinical outcome was evaluated by receiver operator characteristic (ROC) curve analysis. RESULTS: Serum IL-15 levels were increased significantly in severe acute pancreatitis (5.8 +/- 0.5 pg/mL), and they were correlated with Ranson, APACHE II, and Japanese severity score. Serum IL-15 levels were greater in patients with organ dysfunction, patients with infection, and nonsurvivors (P < 05 each). Incidences of organ dysfunction in patients whose IL-15 levels were less than 3.0, 3.0-5.3, and greater than or equal to 5.3 pg/mL, were 8%, 31%, and 89%, respectively (P < .001). Usefulness of IL-15 for the prediction of organ dysfunction was superior to CRP, IL-6, and IL-8, and it was similar to Ranson, APACHE II, and Japanese severity score. Incidences of infection in patients whose IL-15 levels were less than 5.5, 5.5-9.0, and greater than or equal to 9.0 pg/mL, were 7%, 25%, and 50%, respectively (P < .05). Mortality rates in patients whose IL-15 levels were less than 5.5, 5.5-9.0, and greater than or equal to 9.0 pg/mL, were 11%, 25%, and 80%, respectively (P < .001). Usefulness of IL-15 for the prediction of death was superior to CRP, IL-6, and IL-8. CONCLUSIONS: Serum IL-15 level is a useful predictor of the complications (especially organ dysfunction) and mortality in severe acute pancreatitis.
• Treatment strategy against infection: clinical outcome of continuous regional arterial infusion, enteral nutrition, and surgery in severe acute pancreatitis.

  Takeo Yasuda; Takashi Ueda; Yoshifumi Takeyama; Makoto Shinzeki; Hidehiro Sawa; Takahiro Nakajima; Ippei Matsumoto; Tsunenori Fujita; Tetsuya Sakai; Tetsuo Ajiki; Yasuhiro Fujino; Yoshikazu Kuroda

  Journal of gastroenterology SPRINGER TOKYO 42 (8) 681 - 9 0944-1174 2007/08 [Refereed]
   

  BACKGROUND: In severe acute pancreatitis (SAP), infectious complications are the main contributors to high mortality. Since 1995, we have performed continuous regional arterial infusion of protease inhibitor and antibiotics (CRAI) and enteral nutrition (EN) as prevention therapies against infection. When infected pancreatic necrosis was proven, surgical intervention was adapted. The aim of this study was to investigate the clinical outcome of these treatments. METHODS: We examined the relationship between the historical change of treatment strategy and clinical outcome. We divided 84 patients with acute necrotizing pancreatitis into two groups, CRAI (-) and CRAI (+), and compared the outcome. We divided 145 patients with SAP into two groups, EN (-) and EN (+), and compared the outcome. We also analyzed the outcome of surgical treatment. RESULTS: In the CRAI (+) group, the incidence of infection, the frequency of surgery, and the mortality rate were lower than those in CRAI (-) group: 34% versus 51%, 27% versus 63% (P < 0.05), and 37% versus 54%, respectively. In the EN (+) group, the frequency of surgery and the mortality rate were lower than those in the EN (-) group: 23% versus 32% and 19% versus 35% (P < 0.05), respectively. These improvement effects were manifest in stage 3 (9 < or = Japanese Severity Score < or = 14). Treatment outcome of necrosectomy for infected pancreatic necrosis was still poor. Bleeding and abscess-gut fistula were postoperative life-threatening complications. CONCLUSIONS: CRAI and EN may improve the clinical outcome of SAP, reducing infection and averting pancreatic surgery.
• Stage IVa膵癌の治療戦略 教室におけるStage IVa膵癌の成績と治療戦略

  藤野 泰宏; 神垣 隆; 酒井 哲也; 高瀬 至郎; 松本 逸平; 黒田 嘉和

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 40 (7) 1068 - 1068 0386-9768 2007/07 [Refereed]
  
• 胆道癌に対する補助化学療法としてのgemcitabine投与の意義

  味木 徹夫; 藤田 恒憲; 神垣 隆; 高瀬 至郎; 松本 逸平; 新関 亮; 藤野 泰宏; 黒田 嘉和; 具 英成

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 40 (7) 1161 - 1161 0386-9768 2007/07 [Refereed]
  
• Impact of gemcitabine on the survival of patients with stage IV pancreatic cancer.

  Yasuhiro Fujino; Takashi Ueda; Takashi Kamigaki; Shiro Takase; Tetsuo Ajiki; Yasuhisa Kamoda; Ippei Matsumoto; Takeo Yasuda; Yoshikazu Kuroda

  Pancreas LIPPINCOTT WILLIAMS & WILKINS 34 (3) 335 - 9 0885-3177 2007/04 [Refereed]
   

  OBJECTIVES: The prognosis of patients with advanced pancreatic cancer remains very poor. This study was designed to elucidate the prognostic factors of patients with pancreatic cancer to evaluate appropriate treatment with gemcitabine. METHODS: Ninety-nine consecutive patients with stage IV pancreatic cancer were treated in the gemcitabine era at the Kobe University Hospital. Prognostic variables for survival were analyzed (sex, age, performance status, main site of the tumor, tumor size, major vessel invasion, distal metastasis, resection, gemcitabine, radiation, and pathological factors). The Cox proportional hazards model was used to determine the factors influencing the survival of patients with stage IV pancreatic cancer. RESULTS: Multivariate analysis revealed that pancreatic resection, gemcitabine, and distant metastasis significantly influenced the survival of all patients with stage IV pancreatic cancer. Pancreatic resection and gemcitabine were significant factors influencing the survival of patients with stage IVa pancreatic cancer, whereas gemcitabine was the strongest factor influencing stage IVb pancreatic cancer. CONCLUSIONS: Gemcitabine has a possible role for stage IV pancreatic cancer.
• Application of the two-layer method on pancreas digestion results in improved islet yield and maintained viability of isolated islets.

  Tadahiro Goto; Yasuki Tanioka; Tetsuya Sakai; Sachio Terai; Yasuhisa Kamoda; Shiri Li; Tomohiro Tanaka; Toshiaki Tsujimura; Ippei Matsumoto; Yasuhiro Fujino; Yasuyuki Suzuki; Yoshikazu Kuroda

  Transplantation LIPPINCOTT WILLIAMS & WILKINS 83 (6) 754 - 8 0041-1337 2007/03 [Refereed]
   

  BACKGROUND: Oxygenation of the pancreas during preservation by the two-layer method (TLM) has shown beneficial effects in islet transplantation. Here, we apply this concept (oxygenation) to the isolation process. METHODS: Rat pancreases were digested using four different methods. Pancreases were digested with preoxygenated perfluorocarbon (PFC) in group 2 and without it in group 1. Additionally, adenosine was included in the collagenase solution in subgroups B but not in subgroups A. Islet yields and viability were compared between groups. RESULTS: Tissue oxygen tension in group 1 was essentially zero during digestion, but rapidly reached around 300 mm Hg and was maintained in group 2. The tissue adenosine triphosphate (ATP) level in rat pancreas just after laparotomy (control) was 4.2+/-0.7 micromol/g dry weight; after digestion, it was 0.12+/-0.03 micromol/g, 0.70+/-0.10 micromol/g, 0.30+/-0.18 micromol/g, and 2.90+/-0.80 micromol/g in groups 1A, 1B, 2A, and 2B, respectively. No significant differences were observed between group 2B and control (P=0.19). Islet yields (IEQ/pancreas) were 1600+/-400, 1400+/-400, 1300+/-400, and 2400+/-100 in groups 1A, 1B, 2A, and 2B, respectively. The islet yield of group 2B was significantly higher than other groups (P<0.05). The cure rate after transplanting 200 islets into athymic nude mice did not differ (80% in all groups). The stimulation indices in the four groups were also the same. CONCLUSIONS: Tissue ATP levels after digestion were well maintained using TLM with adenosine digestion method. Consequently, greater numbers of islets could be retrieved. The new method was at least equivalent to islet function isolated by conventional method. Clinical study is therefore warranted.
• 教室における膵癌の治療成績と新しい治療の試み

  藤野 泰宏; 松本 逸平; 上田 隆; 神垣 隆; 高瀬 至郎; 味木 徹夫; 外山 博近; 鈴木 康之; 黒田 嘉和

  日本外科学会雑誌 (一社)日本外科学会 108 (臨増2) 505 - 505 0301-4894 2007/03 [Refereed]
  
• 胆道癌に対する外来化学療法としてのgemcitabine投与の成績

  味木 徹夫; 藤田 恒憲; 神垣 隆; 高瀬 至郎; 松本 逸平; 安田 武生; 新関 亮; 外山 博近; 藤野 泰宏; 具 英成; 黒田 嘉和

  日本消化器病学会雑誌 (一財)日本消化器病学会 104 (臨増総会) A156 - A156 0446-6586 2007/03 [Refereed]
  
• Pancreaticobronchial fistula associated with chronic pancreatitis: report of a case.

  Takeo Yasuda; Takashi Ueda; Yasuhiro Fujino; Ippei Matsumoto; Takahiro Nakajima; Hidehiro Sawa; Tsunenori Fujita; Tetsuo Ajiki; Yasuyuki Suzuki; Yoshikazu Kuroda

  Surgery today SPRINGER 37 (4) 338 - 41 0941-1291 2007 [Refereed]
   

  We report a rare case of pancreaticobronchial fistula caused by chronic pancreatitis. A 46-year-old man with a history of chronic alcoholic pancreatitis was referred to us for investigation of dyspnea and bloody sputum. Chest radiography showed a bilateral pneumonia-like shadow, with severe atelectasis in the left lower lung field. Abdominal computed tomography showed a huge pancreatic pseudocyst in the left upper abdomen. The pseudocyst extended as a soft mass from the retroperitoneum into the posterior mediastinum with gas. The pancreatic amylase level in the sputum was 57,500 IU/l. The organism cultured from the sputum was Pseudomonas aeruginosa. Based on these findings, we diagnosed a pancreaticobronchial fistula created by the infected pseudocyst penetrating directly through the dome of the diaphragm to the bronchial tree. External drainage of the infected pseudocyst improved the patient's respiratory condition, allowing him to undergo distal pancreatectomy and splenectomy. Thereafter, he did not suffer any further symptoms.
• Improved quantity and in vivo function of islets isolated by reduced pressure-controlled injection of collagenase in a rat model.

  Shiri Li; Tetsuya Sakai; Yasuyuki Suzuki; Tadahiro Goto; Tomohiro Tanaka; Takuro Yoshikawa; Keitaro Kakinoki; Yasuki Tanioka; Ippei Matsumoto; Yasuhiro Fujino; Yoshikazu Kuroda

  Cell transplantation COGNIZANT COMMUNICATION CORP 16 (5) 539 - 45 0963-6897 2007 [Refereed]
   

  In islet transplantation, insufficient yield is a major obstacle to one-donor/one-recipient transplant. Collagenase, which is injected via a pancreatic duct to separate islets from acini, can so easily distribute into the islet core that it may result in disruption of islets. The purpose of this study was to evaluate the superiority of reduced pressure-controlled collagenase injection (RPCI) at 80 mmHg on islet isolation to injection at 180 mmHg by examining in vivo transplant experiments besides the yield and the glucose stimulation test in a rat model. Lewis rat pancreases were distended with collagenase solution at 80 mmHg pressure as the RPCI group (group 1) and at 180 mmHg (group 2), followed by isolation. The yield in group 1 (1100 +/- 160 islets with 2750 +/- 530 IEQ) was significantly higher than that in group 2 (900 +/- 130 islets with 1570 +/- 350 IEQ, p < 0.01) due to the significant difference of the number of islets sized >150 microm in diameter, although the purity was not significantly different between the two groups. Stimulation indices in the glucose stimulation tests were 2.88 +/- 1.12 in group 1 and 1.93 +/- 0.62 in group 2 (p < 0.05). The cure rate by transplantation of 100 islets to diabetic nude mice in group 1 (8/10) was significantly higher than that in group 2 (3/10, p < 0.05). In a syngenic transplant model of 90% of islets isolated from one donor, the cure rates were 100% and 67% in groups I and 2, respectively (NS). The area under the curve on the graph of IPGTT on postoperative day 28 in group I was significantly smaller than that in group 2 (p < 0.05). In conclusion, our data show that RPCI at 80 mmHg could contribute to consistently high islet yield and in vivo function in a rat model. It was suggested that the current human protocol should be reviewed from this viewpoint.
• Long-term assessments after pancreaticoduodenectomy with pancreatic duct invagination anastomosis.

  Yasuhiro Fujino; Yasuyuki Suzuki; Ippei Matsumoto; Tetsuya Sakai; Tetsuo Ajiki; Takashi Ueda; Yoshikazu Kuroda

  Surgery today SPRINGER 37 (10) 860 - 6 0941-1291 2007 [Refereed]
   

  PURPOSE: The purpose of this cohort was to evaluate the long-term patency of the anastomosis and the remnant pancreatic functions. METHODS: Fifty-six consecutive patients undergoing a pancreaticoduodenectomy with pancreatic duct invagination anastomosis were enrolled in this study. During the follow-up, changes in the remnant pancreatic duct size, pancreatic exocrine and endocrine functions, and nutritional status were monitored. RESULTS: No seriously activated pancreatic fistula, no hemorrhagic complications, no reoperations, and no in-hospital deaths were observed after surgery. A dilatation of remnant pancreatic duct was detected a total of 37 times (51%) during annual computed tomography (CT) evaluations. Pancreatic dysfunctions were observed in a considerable number of patients (exocrine 4/12, 9/14, and 8/16, endocrine 9/35, 8/27, and 4/16 at 1, 2, and 3 postoperative years, respectively). Functional declines in the remnant pancreas, duct dilatation, and a decrease in the body mass index were observed from the first year. However, these data did not progressively deteriorate thereafter, at least during the first 3 postoperative years. This study demonstrated a significant correlation between the duct dilatation and endocrine dysfunction. CONCLUSION: Our pancreatic duct invagination anastomosis resulted in somewhat limited long-term outcomes, although it did prevent serious complications in the short-term.
• Treatment outcome of selective digestive decontamination and enteral nutrition in patients with severe acute pancreatitis.

  Hidehiro Sawa; Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Makoto Shinzeki; Naoki Matsumura; Takahiro Nakajima; Ippei Matsumoto; Tsunenori Fujita; Tetsuo Ajiki; Yasuhiro Fujino; Yoshikazu Kuroda

  Journal of hepato-biliary-pancreatic surgery SPRINGER TOKYO 14 (5) 503 - 8 0944-1166 2007 [Refereed]
   

  BACKGROUND/PURPOSE: Sepsis due to infected pancreatic necrosis is the most serious complication in the late phase of severe acute pancreatitis (SAP). Bacterial translocation from the gut is thought to be the main cause of pancreatic infection. The possibility has recently been reported that selective digestive decontamination (SDD) and enteral nutrition (EN) may alleviate the complications and reduce the mortality rate in patients with SAP. We analyzed the treatment outcome of SDD and EN in patients with SAP. METHODS: We divided 90 patients with SAP into three groups: SDD(-)EN(-),group A; SDD(+)EN(-), group B; and SDD(+)EN(+), group C. Clinical outcome was analyzed retrospectively. The effect of SDD was compared in groups A and B, and the effect of EN was compared in groups B and C. RESULTS: The background of patients was not significantly different between the groups. SDD reduced the incidence of organ dysfunction (from 70% to 59%) and the mortality rate (from 40% to 28%), but the differences were not significant. EN reduced the incidence of infected pancreatic necrosis (from 31% to 24%) and the frequency of surgery for pancreas (from 28% to 18%), and further reduced the mortality rate (from 28% for SDD to 16%), but the differences were not significant. The peripheral lymphocyte count was significantly increased in patients with EN. CONCLUSIONS: SDD and EN did not significantly affect the treatment outcome in SAP. However, the results in this study raise the possibility that SDD and EN may decrease the complications and reduce the mortality rate in SAP. The efficacy of SDD and EN for SAP should be evaluated in a randomized controlled trial.
• 腹腔鏡下手術後ポートサイト・ヘルニア症例の検討

  中村 哲; 黒田 大介; 川崎 健太郎; 山本 将士; 安田 貴志; 金光 聖哲; 外山 博近; 松本 逸平; 高瀬 至郎; 藤田 恒憲; 味木 徹夫; 神垣 隆; 藤野 泰宏; 黒田 嘉和

  日本内視鏡外科学会雑誌 (一社)日本内視鏡外科学会 11 (7) 418 - 418 1344-6703 2006/12 [Refereed]
  
• [A case of successful treatment with transcatheter arterial embolization for a ruptured aneurysm of the gastroduodenal artery presenting with a hemosuccus pancreaticus].

  Ippei Matsumoto; Takashi Ueda; Tetsuo Ajiki; Takeo Yasuda; Tsunenori Fujita; Yasuhiro Fujino; Yasuyuki Suzuki; Yoshikazu Kuroda

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 103 (12) 1397 - 402 0446-6586 2006/12 [Refereed]
   

  A 55-year-old male heavy drinker was taken to another hospital because of loss of consciousness. Laboratory data showed anemia and endoscopy of the upper gastrointestinal tract disclosed intraduodenal bleeding from the ampulla of Vater. Further examinations were scheduled. However, three days later, he was given emergency admission to our hospital because of massive rectal bleeding and circulatory shock. Abdominal contrast-enhanced CT showed a pseudoaneurysm in a pseudocyst in the head of the pancreas. Emergency angiography revealed a ruptured pseudoaneurysm of the gastroduodenal artery 15 mm in diameter. He was successfully treated with transcatheter arterial embolization. ERCP demonstrated the pseudocyst communicating from the main pancreatic duct in the pancreatic head. The final diagnosis was ruptured pseudoaneurysm of the gastroduodenal artery into a pseudocyst, presenting with hemosuccus pancreaticus, secondary to chronic pancreatitis.
• Gemcitabine投与により肝転移が消失し、手術を施行しえた進行胆嚢癌の1例

  森本 大樹; 味木 徹夫; 高瀬 至郎; 藤田 恒憲; 松本 拓; 美田 良保; 安田 武生; 松本 逸平; 神垣 隆; 上田 隆; 藤野 泰宏; 鈴木 康之; 黒田 嘉和

  日本臨床外科学会雑誌 日本臨床外科学会 67 (増刊) 579 - 579 1345-2843 2006/10 [Refereed]
  
• Outcomes of surgery for intraductal papillary mucinous neoplasms of the pancreas.

  Yasuhiro Fujino; Yasuyuki Suzuki; Takuro Yoshikawa; Tetsuo Ajiki; Takashi Ueda; Ippei Matsumoto; Yoshikazu Kuroda

  World journal of surgery SPRINGER 30 (10) 1909 - 14 0364-2313 2006/10 [Refereed]
   

  BACKGROUND: Our objective was to evaluate outcomes of surgery for intraductal papillary mucinous neoplasms of the pancreas (IPMN) in terms of the clinicopathological features. METHODS: Fifty-seven patients with IPMN were examined using clinicopathological analyses to evaluate appropriate surgical treatment, including total pancreatectomy (TP). IPMN was classified into two types: main-duct type (MD, n = 33) and branch-duct type (BD, n = 24). RESULTS: Ultrasound (US) and computed tomography (CT) examinations easily revealed the main site of the lesions. Intraoperative US was the most useful device for diagnosis of lateral spreading, and accuracy rates were 74% for MD and 96% for BD. TP was performed on 16 patients and was appropriate for removing neoplastic lesions with malignancy or malignant potential in 12. Three patients who underwent partial pancreatectomy with involved cancer died of progressive disease. MD is a strong predictive factor in malignancy and indicative of TP. Concerning long-term outcomes, 5 of 16 patients suffered from severe hypoglycemia, and 2 of 16 died from this condition. CONCLUSION: Partial resection with cancer clearance was applied for BD-type IPMN. TP should be performed on selected patients with MD-type IPMN.
• 膵癌に対するgemcitabine術後補助化学療法における腫瘍マーカーの意義

  神垣 隆; 高瀬 至郎; 中村 哲; 松本 逸平; 藤田 恒憲; 味木 徹夫; 上田 隆; 藤野 泰宏; 黒田 嘉和

  日本癌治療学会誌 (一社)日本癌治療学会 41 (2) 686 - 686 0021-4671 2006/09 [Refereed]
  
• 教室におけるStage IVb浸潤性膵管癌の治療成績

  藤野 泰宏; 鈴木 康之; 神垣 隆; 高瀬 至郎; 味木 徹夫; 松本 逸平; 上田 隆; 黒田 嘉和

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 39 (7) 1157 - 1157 0386-9768 2006/07 [Refereed]
  
• 腫瘍マーカーからみた膵癌の予後判定

  加茂田 泰久; 藤野 泰宏; 鈴木 康之; 上田 隆; 松本 逸平; 高瀬 至郎; 神垣 隆; 黒田 嘉和

  日本消化器外科学会雑誌 (一社)日本消化器外科学会 39 (7) 1317 - 1317 0386-9768 2006/07 [Refereed]
  
• Effect of donor age on function of isolated human islets.

  Sung-Hee Ihm; Ippei Matsumoto; Toshiya Sawada; Masahiko Nakano; Hui J Zhang; Jeffrey D Ansite; David E R Sutherland; Bernhard J Hering

  Diabetes AMER DIABETES ASSOC 55 (5) 1361 - 8 0012-1797 2006/05 [Refereed]
   

  This study intended to evaluate the impact of donor age on the function of isolated islets. Analysis of human islets from cadaveric donors (age 16-70 years) was performed using glucose-stimulated insulin release (GSIR) (n = 93), islet ATP content (n = 27), diabetic nude mouse bioassay (n = 72), and the insulin secretory function after single-donor clinical islet allotransplantation (n = 7). The GSIR index was significantly higher in younger donors (age < or =40 years) than in older donors and negatively correlated with the donor age (r = -0.535). Islet ATP was higher in younger donors (115.7 +/- 17.7 vs. 75.7 +/- 6.6 pmol/microg DNA). The diabetes reversal rate of mice with 2,000 IE was significantly higher in younger donors (96 vs. 68%). C-peptide increment to glucose during intravenous glucose tolerance test at days 90-120 after clinical transplantation showed negative correlation with donor age (r = -0.872) and positive correlation with the islet mass (r = 0.832). On the other hand, acute insulin response to arginine only showed correlation with the islet mass and not with donor age. These results show that insulin secretory response to glucose deteriorates with increasing age and that it may be related to changes in ATP generation in beta-cells.
• 切除不能胆道癌に対するgemcitabineの有用性

  味木 徹夫; 神垣 隆; 黒田 嘉和; 高瀬 至郎; 藤田 恒憲; 美田 良保; 堀 宏成; 松本 拓; 森本 大樹; 松本 逸平; 岡崎 太郎; 藤野 泰宏; 鈴木 康之

  日本消化器病学会雑誌 (一財)日本消化器病学会 103 (臨増総会) A197 - A197 0446-6586 2006/03 [Refereed]
  
• 胆道走行異常からみた術中胆道造影の有効性

  藤田恒憲; AJIKI, Tetsuo; 松本逸平; 森本大樹; 松本拓; 美田吉保; 堀宏成; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  日本外科学会雑誌 107巻, 臨増2, pp.376-376 2006/03
• 切除症例からみたIPMNの手術術式の選択

  FUJINO, Yasuhiro; SUZUKI, Yasuyuki; AJIKI, Tetsuo; 松本逸平; UEDA, Takashi; KURODA; Yoshikazu

  日本外科学会雑誌 107巻, 臨増2, pp.513-513 2006/03
• 急性膵炎に対する輸液と栄養管理 重症急性膵炎患者の栄養管理の検討

  沢秀博; UEDA, Takashi; 安田武生; 中島高広; 松本逸平; 藤田恒憲; AJIKI, Tetsuo; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; TAKEYAMA,Yoshifumi; KURODA, Yoshikazu

  日本腹部救急医学会雑誌 26巻, 2号, pp.234-234 2006/02
• 急性胆嚢炎手術例の患者背景と手術成績

  松本拓; 藤田恒憲; AJIKI, Tetsuo; 松本逸平; 美田良保; 堀宏成; 森本大樹; 安田武生; UEDA, Takashi; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  日本腹部救急医学会雑誌 26巻, 2号, pp.316-316 2006/02
• Intrahepatic segmental primary sclerosing cholangitis: report of a case.

  Taku Matsumoto; Tetsuo Ajiki; Ippei Matsumoto; Masahiro Tominaga; Hiroshige Hori; Yoshiyasu Mita; Tsunenori Fujita; Yasuhiro Fujino; Yasuyuki Suzuki; Yonson Ku; Yoshikazu Kuroda

  Surgery today SPRINGER 36 (7) 638 - 41 0941-1291 2006 [Refereed]
   

  A 67-year-old woman was referred to our hospital for investigation of epigastric discomfort. Computed tomography (CT) showed dilatation of the intrahepatic bile duct in the left lobe of the liver, endoscopic cholangiography showed complete stenosis of the left main branch of intrahepatic bile duct, and CT during angiography showed decreased portal blood flow to segment 3 of the liver. Based on these findings, we suspected intrahepatic cholangiocarcinoma and performed left lobectomy of the liver. However, pathological examination revealed fibrosis and infiltration of inflammatory lymphoid cells around the stenotic bile duct and periportal area, without any evidence of malignancy. Since these findings were compatible with sclerosing cholangitis and the patient did not have a disorder that would cause secondary sclerosing cholangitis, the final diagnosis was primary sclerosing cholangitis (PSC). It is difficult to distinguish segmental PSC from cholangiocarcinoma; thus we think surgical resection is an appropriate therapeutic and diagnostic procedure for segmental intrahepatic bile duct stenosis.
• 卵巣転移を認めた胆嚢癌の1例

  美田良保; AJIKI, Tetsuo; 藤田恒憲; 堀宏成; 松本拓; 松本逸平; FUJINO, Yasuhiro; 鈴木泰之; KURODA, Yoshikazu; 中村幸士; 生橋義之

  日本臨床外科学会雑誌 66巻, 増刊, pp.791-791 2005/10
• 進行度からみた十二指腸乳頭部癌に対する手術術式

  AJIKI, Tetsuo; SUZUKI, Yasuyuki; FUJINO, Yasuhiro; 藤田恒憲; 松本逸平; 堀宏成; 美田良保; 松本拓; UEDA, Takashi; KURODA; Yoshikazu

  日本臨床外科学会雑誌 66巻, 増刊, pp.245-245 2005/10
• Possibility of islet transplantation from a nonheartbeating donor pancreas resuscitated by the two-layer method.

  Tomohiro Tanaka; Yasuyuki Suzuki; Yasuki Tanioka; Tetsuya Sakai; Keitaro Kakinoki; Tadahiro Goto; Shiri Li; Takuro Yoshikawa; Ippei Matsumoto; Yasuhiro Fujino; Yoshikazu Kuroda

  Transplantation LIPPINCOTT WILLIAMS & WILKINS 80 (6) 738 - 42 0041-1337 2005/09 [Refereed]
   

  BACKGROUND: The shortage of cadaveric donors is a problem in islet transplantation, and recent improvements in this field have led to renewed interest in the use of nonheartbeating (NHB) donors. NHB donor pancreata that could provide a significant source for islet transplantation are associated with warm ischemic injury. We tested whether the two-layer method (TL) could improve islet yield and function from damaged pancreata after warm ischemia (WI). METHODS: Lewis rats were divided into six groups. In groups 1 to 3, rats were subjected to 0, 30, and 45 minutes of WI, respectively. Islets were isolated immediately (subgroup a) or after 3-hour preservation with TL (subgroup b). Isolated islets were assessed in terms of islet yield and in vivo function. We also assessed the pancreatic tissue ATP concentration before isolation and distended pancreata morphologically after chemical digestion by H&E staining. RESULTS: Islet yield decreased significantly after 30 minutes of WI in group 2a, whereas TL preservation doubled this decreased yield in group 2b. Forty-five minutes of WI resulted in nearly no islet yield in both groups 3a and 3b. The success rates of transplantation in groups 1a, 1b, 2a, and 2b were 100%, 100%, 0%, and 75%, respectively. Increased tissue ATP levels and alleviation of morphological islet damage were observed in group 2b. CONCLUSIONS: These results demonstrated that pancreata damaged from 30-minute WI were restored by 3-hour TL preservation. TL may allow the selective use of NHB donors as an alternative source for islet transplantation.
• 膵癌に対し陽子線治療を含む集学的治療を施行した一剖検例

  高瀬至郎; KAMIGAKI, Takashi; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; 松本逸平; AJIKI, Tetsuo; KURODA; Yoshikazu; TAMURA, Takao; 村上昌雄; 菱川良夫; 西崎朗; 上山茂光

  日本癌治療学会誌 40巻, 2号, pp.693-693 2005/09
• Detailed analysis of mucosal restoration of the small intestine after the cavitary two-layer cold storage method.

  Takuro Yoshikawa; Yasuyuki Suzuki; Yasuhiro Fujino; Keitaro Kakinoki; Shiri Li; Tadahiro Goto; Tomohiro Tanaka; Ippei Matsumoto; Tetsuya Sakai; Yasuki Tanioka; Hiroshi Yokozaki; Yoshikazu Kuroda

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons BLACKWELL PUBLISHING 5 (9) 2135 - 42 1600-6135 2005/09 [Refereed]
   

  Small bowel transplantation (SBT) is associated with a high incidence of infectious complications because of ischemia/reperfusion (I/R) mucosal injury concomitant with potent immunosuppression. In this study, we evaluated whether the cavitary two-layer method (cTLM) could reduce I/R injury and allow early mucosal restoration, particularly after prolonged preservation and transplantation. Canine heterotopic segmental SBT was performed immediately without preservation (group 1), after 24-h preservation in UW solution (group 2) or by the cTLM (group 3). The graft samples were taken 1 h after reperfusion and on days 1, 4 and 7. We assessed graft mucosa with detailed microscopic and electromicroscopic analyses. In Group 3, histological injury and cell apoptosis after transplantation were significantly alleviated and rapidly recovered to a similar level of group 1. The mucosal restoration was morphologically completed within 4 days. In contrast, in group 2, more pronounced mucosal injury and delayed recovery were noted. Crypt cell proliferation activity was well maintained in groups 1 and 3 throughout the experimental period. Our ultrastructural analysis suggested that mitochondrial integrity achieved by the cTLM was a basal mechanism under the prompt mucosal restoration. The cTLM could reduce I/R injury, facilitate mucosal regeneration and restore the nearly normal structure early after SBT.
• 胆道癌における腹腔細胞診の有用性

  AJIKI, Tetsuo; 松本逸平; 藤田恒憲; FUJINO, Yasuhiro; 美田良保; 堀宏成; 松本拓; UEDA, Takashi; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  胆道 19巻, 3号, pp.362-362 2005/08
• 順行性腹腔鏡下胆嚢摘出術および術中胆道造影の有用性

  藤田恒憲; AJIKI, Tetsuo; 堀宏成; 美田良保; 松本拓; 松本逸平; UEDA, Takashi; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  胆道 19巻, 3号, pp.374-374 2005/08
• 浸潤性膵管癌に対するGemcitabineを用いた膵動注・肝動注療法

  FUJINO, Yasuhiro; SUZUKI, Yasuyuki; 吉川卓郎; KAMIGAKI, Takashi; AJIKI, Tetsuo; 高瀬至郎; 松本逸平; UEDA, Takashi; KURODA; Yoshikazu

  日本消化器外科学会雑誌 一般社団法人日本消化器外科学会 38巻, 7号, pp.1223-1223 (7) 1223 - 1223 0386-9768 2005/07
• 消化器癌化学療法の最適化をめぐって 基礎的データに基づいた胆道癌に対する新規抗癌剤投与とその実際

  AJIKI, Tetsuo; 高瀬至郎; KAMIGAKI, Takashi; 藤田恒憲; 美田良保; 堀宏成; 松本逸平; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  日本消化器外科学会雑誌 一般社団法人日本消化器外科学会 38巻, 7号, pp.921-921 (7) 921 - 921 0386-9768 2005/07
• 術中胆道造影からみた膵液胆管逆流現象についての検討

  藤田恒憲; AJIKI, Tetsuo; 松本逸平; 堀宏成; 美田良保; 松本拓; UEDA, Takashi; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  日本消化器外科学会雑誌 一般社団法人日本消化器外科学会 38巻, 7号, pp.1067-1067 (7) 1067 - 1067 0386-9768 2005/07
• 胆石性重症急性膵炎における経過の予知

  中島高広; UEDA, Takashi; 松村直樹; 沢秀博; 松本逸平; 藤田恒憲; AJIKI, Tetsuo; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; TAKEYAMA,Yoshifumi; KURODA, Yoshikazu

  膵臓 20巻, 3号, pp.258-258 2005/06
• 癌マッピングからみたss・se胆嚢癌の治療方針

  AJIKI, Tetsuo; SUZUKI, Yasuyuki; FUJINO, Yasuhiro; 藤田恒憲; 松本逸平; UEDA, Takashi; 堀宏成; 美田良保; 松本拓; 富永正博; KU, Yeisei; KURODA, Yoshikazu

  日本外科学会雑誌 106巻, 臨増, pp.605-605 2005/04
• 限局した肝内胆管狭窄を呈した原発性硬化性胆管炎の2手術例

  松本拓; AJIKI, Tetsuo; 藤田恒憲; 松本逸平; 美田良保; 堀宏成; UEDA, Takashi; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; TOMINAGA; Masahiro, KU; Yeisei; KURODA; Yoshikazu

  日本消化器病学会雑誌 102巻, 臨増総会, pp. A335-A335 2005/03
• Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes.

  Bernhard J Hering; Raja Kandaswamy; Jeffrey D Ansite; Peter M Eckman; Masahiko Nakano; Toshiya Sawada; Ippei Matsumoto; Sung-Hee Ihm; Hui-Jian Zhang; Jamen Parkey; David W Hunter; David E R Sutherland

  JAMA AMER MEDICAL ASSOC 293 (7) 830 - 5 0098-7484 2005/02 [Refereed]
   

  CONTEXT: Islet allografts from 2 to 4 donors can reverse type 1 diabetes. However, for islet transplants to become a widespread clinical reality, diabetes reversal must be achieved with a single donor to reduce risks and costs and increase the availability of transplantation. OBJECTIVE: To assess the safety of a single-donor, marginal-dose islet transplant protocol using potent induction immunotherapy and less diabetogenic maintenance immunosuppression in recipients with type 1 diabetes. A secondary objective was to assess the proportion of islet transplant recipients who achieve insulin independence in the first year after single-donor islet transplantation. DESIGN, SETTING, AND PARTICIPANTS: Prospective, 1-year follow-up trial conducted July 2001 to August 2003 at a single US center and enrolling 8 women with type 1 diabetes accompanied by recurrent hypoglycemia unawareness or advanced secondary complications. INTERVENTIONS: Study participants underwent a primary islet allotransplant with 7271 (SD, 1035) islet equivalents/kg prepared from a single cadaver donor pancreas. Induction immunosuppression was with antithymocyte globulin, daclizumab, and etanercept. Maintenance immunosuppression consisted of mycophenolate mofetil, sirolimus, and no or low-dose tacrolimus. MAIN OUTCOME MEASURES: Safety (assessed by monitoring the severity and duration of adverse events) and efficacy (assessed by studying the recipients' insulin requirements, C-peptide levels, oral and intravenous glucose tolerance results, intravenous arginine stimulation responses, glycosylated hemoglobin levels, and hypoglycemic episodes) associated with the study transplant protocol. RESULTS: There were no serious, unexpected, or procedure- or immunosuppression-related adverse events. All 8 recipients achieved insulin independence and freedom from hypoglycemia. Five remained insulin-independent for longer than 1 year. Graft failure in 3 recipients was preceded by subtherapeutic sirolimus exposure in the absence of measurable tacrolimus trough levels. CONCLUSIONS: The tested transplant protocol restored insulin independence and protected against hypoglycemia after single-donor, marginal-dose islet transplantation in 8 of 8 recipients. These results may be related to improved islet engraftment secondary to peritransplant administration of antithymocyte globulin and etanercept. These findings may have implications for the ongoing transition of islet transplantation from clinical investigation to routine clinical care.
• Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure.

  Saida Abdelli; Jeff Ansite; Raphael Roduit; Tiziana Borsello; Ippei Matsumoto; Toshiya Sawada; Nathalie Allaman-Pillet; Hugues Henry; Jacques S Beckmann; Bernhard J Hering; Christophe Bonny

  Diabetes AMER DIABETES ASSOC 53 (11) 2815 - 23 0012-1797 2004/11 [Refereed]
   

  Pancreatic islet transplantation may successfully restore normoglycemia in type 1 diabetic patients. However, successful grafting requires transplantation of a sufficient number of islets, usually requiring two or more donors. During the isolation process and following clinical transplantation, islets are subjected to severe adverse conditions that impair survival and ultimately contribute to graft failure. Here, we have mapped the major intracellular stress-signaling pathways that may mediate human islet loss during isolation and following cytokine attack. We found that the isolation procedure potently recruits two pathways consisting of |mitogen-activated protein kinase kinase (MKK)7 --> Jun NH(2)-terminal kinase (JNK)/p38 --> c-fos| and the |nuclear factor-kappaB (NF-kappaB) --> iNOS| module. Cytokines activate the |NF-kappaB --> iNOS| and |MKK4/MKK3/6 --> JNK/p38| pathways without recruitment of c-fos. Culturing the islets for 48 h after isolation allows for the activated pathways to return to background levels, with expression of MKK7 becoming undetectable. These data indicate that isolation and cytokines recruit different death pathways. Therefore, strategies might be rationally developed to avoid possible synergistic activation of these pathways in mediating islet loss during isolation and following grafting.
• Improvement in islet yield from obese donors for human islet transplants.

  Ippei Matsumoto; Toshiya Sawada; Masahiko Nakano; Tetsuya Sakai; Baolin Liu; Jeffrey D Ansite; Hui-Jian Zhang; Raja Kandaswamy; David E R Sutherland; Bernhard J Hering

  Transplantation LIPPINCOTT WILLIAMS & WILKINS 78 (6) 880 - 5 0041-1337 2004/09 [Refereed]
   

  BACKGROUND: The feasibility of human islet transplantations has been firmly established. To increase the number of islet transplants, the suitability of pancreases from organ donors considered inappropriate for pancreas transplantations must be evaluated. METHODS: We isolated islets from 114 human cadaver donor pancreases by the automated Ricordi method, followed by purification using continuous-density gradients. We divided the pancreases into two groups by donor body mass index (BMI)--group 1: n=51, BMI of 30 or more; group 2: n=63, BMI of less than 30. We compared the results of human islet isolation, in vitro potency assays, and a nude mouse bioassay. RESULTS: In group 1 (vs. group 2), we found a significantly higher mean pancreas weight (109.5+/-30.7 vs. 90.6+/-24.0 g; P=0.0002); higher mean islet equivalents/pancreas, after digestion (442,565+/-238,741 vs. 289,860+/-158,995; P<0.0001) and after purification (319,129+/-164,002 vs. 215,753+/-126,089; P=0.0002); and a higher islet isolation success rate--defined as isolations yielding more than 300,000 islet equivalents/pancreas, with purities of more than 50% (37.3% [19 of 51 pancreases] vs. 15.9% [10 of 63]; P=0.009). Our in vitro potency assays and bioassay uncovered no differences between the two groups. Notably, all except one of the donor BMIs for the successful isolations in group 2 exceeded 26; the mean donor BMI for the successful isolations (27.3+/-3.0, n=10) was significantly higher than for the unsuccessful isolations (24.8+/-3.3, n=53) (P=0.03). CONCLUSIONS: Pancreases from both overweight (BMI > or = 26 but <30) and obese (BMI > or = 30) cadaver donors are suitable for islet isolation and transplantations. Their use could increase the size of the islet donor pool.
• Caspase-3 inhibitor prevents apoptosis of human islets immediately after isolation and improves islet graft function.

  Masahiko Nakano; Ippei Matsumoto; Toshiya Sawada; Jeff Ansite; Jeremy Oberbroeckling; Hui Jian Zhang; Nicole Kirchhof; Jeff Shearer; David E R Sutherland; Bernhard J Hering

  Pancreas LIPPINCOTT WILLIAMS & WILKINS 29 (2) 104 - 9 0885-3177 2004/08 [Refereed]
   

  OBJECTIVES: Apoptosis appears in islets after isolation, and it has a detrimental effect on the islet function. To improve the outcome of clinical islet transplantation, it is crucial to protect islets from apoptosis. The aim of this study was to determine whether a caspase-3 inhibitor (Z-DEVD-FMK) added to culture media protects islets from apoptosis and to compare the effects of fetal bovine serum (FBS) with human serum albumin (HSA) as a protein supplement in culture. METHODS: Isolated human islets were cultured under 4 different conditions: 0.5% HSA (control), 0.5% HSA + 25 micromol/L Z-DEVD-FMK, 0.5% HSA + 100 micromol/L Z-DEVD-FMK and 10% FBS for 2 days. Next, 1000 IEQ islets precultured with 0.5% HSA and with or without 100 micromol/L Z-DEVD-FMK were transplanted to diabetic nude mice. RESULTS: The islet yields were higher in Z-DEVD-FMK-treated groups, and the inhibitor prevented apoptosis dose dependently. The yield and insulin release were higher in FBS-treated group than in the control group, but FBS did not affect apoptosis. All 6 mice transplanted with islets pretreated with Z-DEVD-FMK, and 3 of 8 mice with control islets became normoglycemic posttransplantation. CONCLUSION: Z-DEVD-FMK prevented apoptosis of isolated human islets and improved its function. FBS (10%) improved the islet yield and insulin secretion more than 0.5% HSA.
• Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody.

  Bernhard J Hering; Raja Kandaswamy; James V Harmon; Jeffrey D Ansite; Sue M Clemmings; Tetsuya Sakai; Stephen Paraskevas; Peter M Eckman; Junichiro Sageshima; Masahiko Nakano; Toshiya Sawada; Ippei Matsumoto; Hui J Zhang; David E R Sutherland; Jeffrey A Bluestone

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons BLACKWELL MUNKSGAARD 4 (3) 390 - 401 1600-6135 2004/03 [Refereed]
   

  We sought to determine whether or not optimizing pancreas preservation, islet processing, and induction immunosuppression would facilitate sustained diabetes reversal after single-donor islet transplants. Islets were isolated from two-layer preserved pancreata, purified, cultured for 2 days; and transplanted into six C-peptide-negative, nonuremic, type 1 diabetic patients with hypoglycemia unawareness. Induction immunosuppression, which began 2 days pretransplant, included the Fc receptor nonbinding humanized anti-CD3 monoclonal antibody hOKT3gamma1 (Ala-Ala) and sirolimus. Immunosuppression was maintained with sirolimus and reduced-dose tacrolimus. Of our six recipients, four achieved and maintained insulin independence with normal HbA1c levels and freedom from hypoglycemia; one had partial islet graft function; and one lost islet graft function 2 weeks post-transplant. The four insulin-independent patients showed prolonged CD4+ T-cell lymphocytopenia; inverted CD4:CD8 ratios; and increases in the percentage of CD4+CD25+ T cells. These cells suppressed the in-vitro proliferative response to donor cells and, to a lesser extent, to third-party cells. Severe adverse events were limited to a transient rash in one recipient and to temporary neutropenia in three. Our preliminary results thus suggest that a combination of maximized viable islet yield, pretransplant islet culture, and preemptive immunosuppression can result in successful single-donor islet transplants.
• Improved islet yield and function with ductal injection of University of Wisconsin solution before pancreas preservation.

  Toshiya Sawada; Ippei Matsumoto; Masahiko Nakano; Nicole Kirchhof; David E R Sutherland; Bernhard J Hering

  Transplantation LIPPINCOTT WILLIAMS & WILKINS 75 (12) 1965 - 9 0041-1337 2003/06 [Refereed]
   

  BACKGROUND: Ensuring sufficient islet yield from preserved pancreases is a critical step in clinical islet transplantation. The aim of this study was to investigate whether pancreatic ductal injection, performed at procurement, using a small volume of preservation solution before cold storage (ductal preservation method) would improve islet yield and function from rat pancreases preserved for 6 and 24 hr. MATERIALS AND METHODS: Islets were isolated from Lewis rats. Pancreases were classified into five groups: fresh (group 1); preserved for 6 hr in University of Wisconsin solution without and with ductal preservation (groups 2 and 3); and preserved for 24 hr in University of Wisconsin solution without and with ductal preservation (groups 4 and 5). We assessed islet yield, function, and viability of pancreatic ductal cells. RESULTS: Islet yields per pancreas in groups 1 to 5 were 2010+/-774, 674+/-450, 1418+/-528, 527+/-263, and 1655+/-618 (islet equivalent) (+/-SD), respectively. Stimulation indices in groups 1 to 5 were 11.97+/-3.17, 6.48+/-4.04, 12.44+/-5.65, 2.56+/-2.03, and 5.55+/-2.71. Functional success rates in groups 1 to 5 were 100%, 0%, 100%, 0%, and 66.7%. Percentages of nonviable pancreatic duct cells in groups 1 to 5 were 3.8+/-2.7%, 59.7+/-4.4%, 19.5+/-7.3%, 64.7+/-4.5%, and 17.2+/-2.6%. In all experiments, the differences were significant between the groups without versus the groups with ductal preservation (P<0.05, group 2 vs. group 3 and group 4 vs. group 5). CONCLUSIONS: Ductal preservation improved islet yield and function after 6 and 24 hr of preservation. Well-preserved pancreatic ducts maintained good distribution of collagenase solution.
• [A case of advanced gastric adenocarcinoma with mild elevation of serum SCC that responded remarkably to adjuvant chemotherapy of ADM, CDDP, ETP and 5-FU (ACVF)].

  Toshiharu Niki; Ippei Matsumoto; Hogara Nishisaki; Hiroki Inoue; Kenichi Hamano; Tetsuo Maeda; Toshio Okutani; Shigeya Hirohata; Takatoshi Nakashima; Kouichi Yasutake; Katsunori Kawaguchi; Terumasa Sashikata

  Gan to kagaku ryoho. Cancer & chemotherapy 30 (1) 117 - 20 0385-0684 2003/01 [Refereed]
   

  A 65-year-old man was referred to our hospital because of weight loss. Endoscopic examination and computed tomography (CT) revealed an advanced gastric cancer with multiple abdominal lymph node swellings. Distal partial gastrectomy was performed but lymph node resection was not done, since it was not thought to be curative. Adjuvant chemotherapy was performed for 4 courses with a regimen of ADM 20 mg/m2 day 1, CDDP 50 mg/m2 day 1, ETP 100 mg/day days 3-7, 5-FU 600 mg/m2 every other day on days 3-29. After 3 courses of ACVF therapy, the patient's serum CEA and SCC level normalized and the lymph node metastases became undetectable by CT scan. No severe side effects were observed at any time during the administration of these medications. In this case, serum SCC level was elevated even though histologic examination did not reveal squamous cell carcinoma but poorly differentiated adenocarcinoma. On immunohistochemical analysis, these tissues were stained diffusely with CEA, locally with AE1 + 3, and partially with PAS or Alcian blue. We speculate that this tumor could have developed the potency of SCC secretions without structural change into squamous metaplasia.
• Impact of two-layer pancreas preservation on islet isolation and transplantation.

  Bernhard J Hering; Ippei Matsumoto; Toshiya Sawada; Masahiko Nakano; Tetsuya Sakai; Raja Kandaswamy; David E R Sutherland

  Transplantation LIPPINCOTT WILLIAMS & WILKINS 74 (12) 1813 - 6 0041-1337 2002/12 [Refereed]
  
• Ultrastructural analyses of pancreatic grafts preserved by the two-layer cold-storage method and by simple cold storage in University of Wisconsin solution.

  Yasuhiro Iwanaga; Yasuyuki Suzuki; Yoshikatsu Okada; Hiroshi Mori; Ippei Matsumoto; Masaaki Mitsutsuji; Yasuki Tanioka; Yasuhiro Fujino; Masahiro Tominaga; Yonson Ku; Yoshikazu Kuroda

  Transplant international : official journal of the European Society for Organ Transplantation SPRINGER-VERLAG 15 (8) 425 - 30 0934-0874 2002/09 [Refereed]
   

  The two-layer cold storage method (TLM) using University of Wisconsin (UW) solution supplies sufficient oxygen to pancreatic grafts during preservation and extends pancreas preservation time to up to 96 h in the canine model. Simple cold storage in UW (UWM) on the other hand, preserves canine pancreas grafts for up to 72 h by preventing cell swelling, mainly because of its high osmotic pressure. The aim of this study is to analyze morphologically dog pancreatic grafts preserved by these two methods with their different mechanisms. Immediately after preservation of canine pancreata by TLM for 72 h and 96 h (group 1 and group 3, respectively), and by UWM for 72 h and 96 h (group 2 and group 4, respectively), tissue ATP levels were determined using high-performance liquid chromatography (HPLC), and detailed morphological analyses of intragraft components were performed using light- and electron microscopy. The mean areas of one mitochondrion and rough endoplasmic reticulum (RER) vacuolization were calculated by computer-graphic analyses using NIH image 1.62 f soft. The tissue ATP levels were significantly higher in groups 1 and 3 than groups 2 and 4 ( P < 0.05). Light microscopy demonstrated no marked difference among the 4 groups. By electron microscopy however, mitochondrial swelling and RER vacuolization were observed in acinar cells to various extents in the 4 groups. They were significantly more evident in group 2 than group 1 ( P < 0.05), and in group 4 than group 3 ( P < 0.05). In conclusion, TLM demonstrated excellent protection of intracellular organelles, mitochondria, and RER, up to 72-96 h. Well-maintained graft ATP levels in TLM groups may result in maintaining the integrity of intracellular organelle membranes as well as cellular membranes.
• Superiority of mild hypothermic (20 degrees C) preservation for pancreatic microvasculature using the two-layer storage method

  Matsumoto, I; Y Suzuki; Y Fujino; Y Tanioka; T Deai; Y Iwanaga; M Mitsutsuji; T Iwasaki; M Tominaga; YS Ku; Y Kuroda

  PANCREAS LIPPINCOTT WILLIAMS & WILKINS 21 (3) 305 - 309 0885-3177 2000/10 [Refereed]
   

  Hypothermia causes vascular endothelial damage that leads to graft microcirculation disorder and eventually thrombosis after reperfusion. The two-layer cold storage method (TL) was previously demonstrated to supply oxygen to the pancreas graft and maintain high adenosine triphosphate tissue concentration. In this study, we evaluated whether mild hypothermic (20 degrees C) preservation using the TL method could reduce endothelial damage while maintaining parenchymal viability. Graft survival by 20 degrees C preservation was investigated using a dog segmental pancreas autotransplantation model (simple storage in University of Wisconsin solution (UW) for 5 and 8 hours or TL for 5, 8, 12, and 24 hrs, respectively). Subsequently, the grafts were preserved in four different conditions (4 and 20 degrees C UW, 4 and 20 degrees C TL) for 8 hours to evaluate microvascular endothelial damage. Trypan blue uptake of vascular endothelium and pancreatic tissue perfusion were evaluated. No graft preserved by 20 degrees C UW for 5 and 8 hours survived (0/7 and 0/4). In contrast, the graft survival rates by 20 degrees C TL for 5, 8, 12, and 24 hours were 100% (5/5), 80% (4/5), 20% (1/5), and 0% (0/4), respectively. In trypan blue uptake analysis, there were significant differences between 4 and 20 degrees C in both UW and TL (4 degrees C UW, 37% [n = 5] vs. 20 degrees C UW, 13% [n = 4] [p < 0.01], 4 degrees C TL, 29% [n = 5] vs. 20 degrees C TL, 10% [n = 5] [p < 0.01]). The perfusion values in 20 degrees C TL were significantly higher than those in other groups at least for up to 120 minutes after reperfusion (p < 0.01). In short-term pancreas preservation, mild hypothermic TL reduced vascular endothelial cell damage and ameliorated graft microcirculation while maintaining parenchymal viability. Mild hypothermic TL may lessen vascular complications in clinical pancreas transplantation when used for several-hour preservation.
• Preservation of dog pancreas before islet isolation with the two-layer method

  Y Tanioka; DER Sutherland; Y Kuroda; Y Suzuki; Matsumoto, I; T Deai

  TRANSPLANTATION PROCEEDINGS ELSEVIER SCIENCE INC 30 (7) 3419 - 3420 0041-1345 1998/11 [Refereed]
  

Conference Activities & Talks

• 局所進行切除不能膵癌に対するConversion surgeryのタイミング〜内科と外科の連携〜 当院における局所進行切除不能膵癌に対するconversion surgeryの短期・長期成績の検討

  吉田 雄太; 松本 逸平; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 鎌田 研; 山雄 健太郎; 竹中 完; 竹山 宜典

  膵臓  2021/08  (一社)日本膵臓学会
  
• 慢性膵炎による難治性疼痛に対する内科的インターベンション治療と外科治療の比較解析

  松本 逸平; 三長 孝輔; 村瀬 貴昭; 宮田 剛; 川口 晃平; 亀井 敬子; 水野 修吾; 糸井 隆夫; 大原 弘隆; 正宗 淳; 阪上 順一; 佐田 尚宏; 竹中 完; 北野 雅之; 乾 和郎; 竹山 宜典

  膵臓  2021/08  (一社)日本膵臓学会
  
• 膵切除術前後における内分泌・代謝動態の前向き観察研究(KIP-MEP study) 膵頭十二指腸切除と膵体尾部切除の相違

  庭野 史丸; 馬場谷 成; 廣峰 義久; 松本 逸平; 亀井 敬子; 武友 保憲; 川畑 由美子; 竹山 宜典; 能宗 伸輔; 池上 博司

  糖尿病  2021/05  (一社)日本糖尿病学会
  
• 尾側膵切除術における新しい縫合糸を用いたバイクリルメッシュ、膵貫通マットレス法の有効性の検討 Transpancreatic mattress double suture(TPMD suture)の有効性について

  吉田 雄太; 松本 逸平; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本外科学会定期学術集会抄録集  2021/04  (一社)日本外科学会
  
• 腹腔鏡下膵頭十二指腸切除術の安全な導入と手術手技

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本外科学会定期学術集会抄録集  2021/04  (一社)日本外科学会
  
• 肝内胆管拡張を伴う進行肝内胆管癌に対する肝左葉切除術

  武部 敦志; 吉田 雄太; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 松本 逸平; 中居 卓也; 竹山 宜典

  日本外科学会定期学術集会抄録集  2021/04  (一社)日本外科学会
  
• 当院における切除可能膵癌に対する術前治療症例の検討

  李 東河; 松本 逸平; 亀井 敬子; 川口 晃平; 吉田 雄太; 松本 正孝; 村瀬 貴昭; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本外科学会定期学術集会抄録集  2021/04  (一社)日本外科学会
  
• 慢性膵炎を巡る諸問題:早期慢性膵炎から外科治療まで 局所合併症を伴う慢性膵炎に対するFrey手術の安全性と有効性

  松本 逸平; 亀井 敬子; 竹山 宜典

  日本消化器病学会雑誌  2021/03  (一財)日本消化器病学会
  
• 膵体尾部切除後膵液瘻低減を可能としたバイクリルメッシュと新規マットレス縫合糸による新しい膵断端処理法

  亀井 敬子; 松本 逸平; 吉田 雄太; 川口 晃平; 村瀬 貴昭; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本消化器外科学会総会  2020/12  (一社)日本消化器外科学会
  
• 膵臓 悪性

  亀井 敬子; 松本 逸平; 川口 晃平; 吉田 雄太; 村瀬 貴昭; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本消化器外科学会雑誌  2020/11  (一社)日本消化器外科学会
  
• 膵臓 悪性

  松本 逸平; 吉田 雄太; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本消化器外科学会雑誌  2020/11  (一社)日本消化器外科学会
  
• 膵臓 良性

  村瀬 貴昭; 松本 逸平; 吉田 雄太; 川口 晃平; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 筑後 孝章; 竹山 宜典

  日本消化器外科学会雑誌  2020/11  (一社)日本消化器外科学会
  
• 急性膵炎におけるプレサルコペニアの臨床的意義に関しての検討

  田中 隆光; 竹中 完; 吉田 晃弘; 田中 秀和; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 中井 敦史; 大本 俊輔; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  日本消化器病学会雑誌  2020/10  (一財)日本消化器病学会
  
• 胆管癌切除後の異時性胆管癌に対する2切除例の報告

  村瀬 貴昭; 武部 敦志; 吉田 雄太; 川口 晃平; 松本 正孝; 李 東河; 亀井 敬子; 里井 俊平; 松本 逸平; 中居 卓也; 木村 雅友; 竹山 宜典

  日本臨床外科学会雑誌  2020/10  日本臨床外科学会
  
• 急性膵炎におけるプレサルコペニアの臨床的意義に関しての検討

  田中 隆光; 竹中 完; 吉田 晃弘; 田中 秀和; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 中井 敦史; 大本 俊輔; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  日本消化器病学会雑誌  2020/10  (一財)日本消化器病学会
  
• 切除可能膵癌の治療戦略-術前治療 vs 切除先行-【術前治療】切除可能膵癌に対する術前化学療法は標準治療となり得るか? Prep-02/JSAP-05臨床第II/III相試験結果より

  和田 慶太; 海野 倫明; 元井 冬彦; 松山 裕; 里井 壯平; 松本 逸平; 青笹 季史; 白川 博文; 藤井 努; 吉富 秀幸; 高橋 進一郎; 庄 雅之; 上野 秀樹; 小菅 智男

  日本外科学会定期学術集会抄録集  2020/08  (一社)日本外科学会
  
• 膵管狭窄症例におけるCT間接所見の検討 微小膵癌と良性膵管狭窄症例の比較

  山雄 健太郎; 竹中 完; 松本 逸平; 竹山 宜典; 沼本 勲男; 鶴崎 正勝; 工藤 正俊

  膵臓  2020/07  (一社)日本膵臓学会
  
• 急性膵炎に対する局所合併症治療 Walled-off necrosisに対するLAMS with 10 FrENCD持続洗浄治療の有用性について

  竹中 完; 石川 嶺; 岡本 彩那; 中井 敦史; 山崎 友裕; 大本 俊介; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓  2020/07  (一社)日本膵臓学会
  
• Disconnected pancreatic duct syndromeの外科治療症例の検討

  松本 正孝; 松本 逸平; 吉田 雄太; 山雄 健太郎; 川口 晃平; 村瀬 貴昭; 大本 俊介; 亀井 敬子; 里井 俊平; 竹中 完; 武部 敦志; 中居 卓也; 竹山 宜典

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵全摘術の現状と展望 膵全摘患者のQOL調査 多施設共同前向き研究結果

  亀井 敬子; 松本 逸平; 加藤 宏之; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵全摘術の現状と展望 膵全摘後の脂肪肝発生頻度とそのリスク解析 膵全摘患者に対する前向き実態調査の結果から

  加藤 宏之; 亀井 敬子; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵全摘術の現状と展望 膵全摘術後の糖尿病コントロールと栄養指標の変化について

  須藤 広誠; 亀井 敬子; 加藤 宏之; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓  2020/07  (一社)日本膵臓学会
  
• 急性膵炎に対する局所合併症治療 Walled-off necrosisに対するLAMS with 10 FrENCD持続洗浄治療の有用性について

  竹中 完; 石川 嶺; 岡本 彩那; 中井 敦史; 山崎 友裕; 大本 俊介; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵管狭窄症例におけるCT間接所見の検討 微小膵癌と良性膵管狭窄症例の比較

  山雄 健太郎; 竹中 完; 松本 逸平; 竹山 宜典; 沼本 勲男; 鶴崎 正勝; 工藤 正俊

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵全摘術の現状と展望 膵全摘患者のQOL調査 多施設共同前向き研究結果

  亀井 敬子; 松本 逸平; 加藤 宏之; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵全摘術の現状と展望 膵全摘後の脂肪肝発生頻度とそのリスク解析 膵全摘患者に対する前向き実態調査の結果から

  加藤 宏之; 亀井 敬子; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵全摘術の現状と展望 膵全摘術後の糖尿病コントロールと栄養指標の変化について

  須藤 広誠; 亀井 敬子; 加藤 宏之; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵癌のconversion surgery:課題と展望 初診時切除不能膵癌に対する非手術療法奏効後切除の前向き観察研究 Prep-04

  元井 冬彦; 中森 正二; 松本 逸平; 里井 壯平; 平野 聡; 川畑 康成; 庄 雅之; 本田 五郎; 木村 康利; 岸和田 昌之; 青笹 季文; 岡野 圭一; 北川 裕久; 村上 義昭; 海野 倫明

  膵臓  2020/07  (一社)日本膵臓学会
  
• 膵全摘術後の栄養障害とその対策

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 庭野 史丸; 廣峰 義久; 馬場谷 成; 中居 卓也; 池上 博司; 竹山 宜典

  外科と代謝・栄養  2020  日本外科代謝栄養学会
  
• バイクリルメッシュと貫通マットレス縫合による新しい尾側膵切除後膵断端処理法の有用性

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本消化器外科学会雑誌  2019/11  (一社)日本消化器外科学会
  
• R0切除後CA19-9遷延上昇は、膵癌術後肝転移再発の高リスク徴候である

  元井 冬彦; 村上 義昭; 松本 逸平; 里井 壯平; 庄 雅之; 本田 五郎; 福本 巧; 青木 修一; 水間 正道; 山上 裕機; 海野 倫明

  日本癌治療学会学術集会抄録集  2019/10  (一社)日本癌治療学会
  
• 膵全摘術の治療成績

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 村瀬 貴昭; 岩崎 寿光; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典

  日本消化器外科学会雑誌  2018/11  (一社)日本消化器外科学会
  
• 膵癌の門脈浸潤診断における造影ハーモニックEUSと造影CTの診断能の比較検討

  中井 敦史; 鎌田 研; 竹中 完; 石川 嶺; 岡本 彩那; 大本 俊介; 三長 孝輔; 山雄 健太郎; 兵頭 朋子; 松本 逸平; 竹山 宜典; 工藤 正俊

  Gastroenterological Endoscopy  2018/10  (一社)日本消化器内視鏡学会
  
• 重症急性膵炎の予後不良予測因子および被包化壊死(WON)合併予測因子の検討

  大本 俊介; 竹中 完; 松本 逸平; 竹山 宜典; 工藤 正俊

  膵臓  2018/05  (一社)日本膵臓学会
  
• 膵頭十二指腸切除術における周術期管理標準化は術後合併症に影響を与えるか? 日本膵切研究会アンケート調査結果報告  [Not invited]

  里井 壯平; 山本 智久; 吉富 秀幸; 元井 冬彦; 廣野 誠子; 藤井 努; 和田 慶太; 有光 秀仁; 庄 雅之; 松本 逸平; 平野 聡; 柳本 泰明; 大塚 将之; 海野 倫明; 山上 裕機; 權 雅憲

  日本外科学会定期学術集会抄録集  2018/04  (一社)日本外科学会
  
• 膵体部の膵神経内分泌腫瘍に合併した膵性胸水の一例

  河野 辰哉; 山雄 健太郎; 中井 敦史; 大本 俊介; 鎌田 研; 三長 孝輔; 宮田 剛; 今井 元; 松本 逸平; 竹山 宜典; 田中 伴典; 筑後 孝章; 林 暁洋; 工藤 正俊

  日本消化器病学会雑誌  2018/03  (一財)日本消化器病学会
  
• 膵液瘻低減を目指したバイクリルメッシュとマットレス縫合を用いた新しい尾側膵切除後膵断端処理法(第1報)

  松本 逸平; 村瀬 貴昭; 亀井 敬子; 中多 靖幸; 里井 俊平; 石川 原; 中居 卓也; 竹山 宜典

  日本消化器外科学会雑誌  2015/10  (一社)日本消化器外科学会
  
• 準緊急手術を行った難治性膵性腹水の3例

  亀井 敬子; 松本 逸平; 村瀬 貴昭; 中多 靖幸; 里井 俊平; 石川 原; 中居 卓也; 竹山 宜典

  日本消化器外科学会雑誌  2015/10  (一社)日本消化器外科学会
  
• 内視鏡外科手術の現状と将来(肝、胆、膵) 膵内視鏡外科の現状と将来 腹腔鏡下尾側膵切除術における当科の経験

  後藤 直大; 外山 博近; 浅利 貞毅; 寺井 祥雄; 石田 潤; 木下 秘我; 蔵満 薫; 松本 拓; 田中 基文; 武部 敦志; 木戸 正浩; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  
• 大動脈周囲リンパ節転移陽性膵癌の治療成績 多施設共同研究解析結果  [Not invited]

  庄 雅之; 村上 義昭; 元井 冬彦; 里井 壮平; 松本 逸平; 川井 学; 本田 五郎; 上村 健一郎; 柳本 泰明; 倉田 昌直; 後藤 直大; 赤堀 宇広; 海野 倫明; 山上 裕機; 中島 祥介

  日本臨床外科学会雑誌  2015/10  日本臨床外科学会
  
• 膵腎同時移植後の急性移植片対宿主病 1症例報告(Acute graft-versus-host disease following simultaneous pancreas-kidney transplantation: report of a case)  [Not invited]

  浅利 貞毅; 松本 逸平; 外山 博近; 後藤 直大; 寺井 祥雄; 石田 潤; 南野 佳英; 植田 亜津紗; 上田 悠貴; 水本 拓也; 味木 徹夫; 松本 拓; 篠崎 健太; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 福本 巧; 具 英成

  MHC: Major Histocompatibility Complex  2015/08  日本組織適合性学会
  
• 神戸大学における劇症肝炎に対する移植プログラム  [Not invited]

  蔵満 薫; 福本 巧; 木下 秘我; 田中 基文; 武部 敦志; 木戸 正浩; 矢野 嘉彦; 三住 拓誉; 松本 拓; 後藤 直大; 浅利 貞毅; 松本 逸平; 味木 徹夫; 具 英成

  移植  2015/08  (一社)日本移植学会
  
• 切除可能膵癌に対する治療戦略 手術先行vs術前治療 肝胆膵 切除可能膵癌に対する治療戦略

  後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 村上 義昭; 川井 学; 元井 冬彦; 上村 健一郎; 庄 雅之; 里井 壯平; 本田 五郎; 山上 裕機; 海野 倫明; 赤堀 宇広; 權 雅憲; 倉田 昌直; 福本 巧; 具 英成

  日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  
• 肝胆膵 膵管内腺癌患者の長期生存率に対する術前胆道ドレナージの効果に関する多施設共同観察研究(A multicenter observational study of potential effect of preoperative biliary drainage on long-term survival in the patients with pancreatic ductal adenocarcinoma)  [Not invited]

  上村 健一郎; 村上 義昭; 里井 壮平; 庄 雅之; 元井 冬彦; 川井 学; 松本 逸平; 本田 五郎; 倉田 昌直; 柳本 泰明; 赤堀 宇広; 浅利 貞毅; 海野 倫明; 山上 裕機

  日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  
• 肝胆膵 切除可能膵癌の術前療法臨床試験における術前切除可能性判定標準化の重要性  [Not invited]

  村上 義昭; 里井 壯平; 元井 冬彦; 川井 学; 本田 五郎; 庄 雅之; 松本 逸平; 上村 健一郎; 倉田 昌直; 赤堀 宇弘; 柳本 泰明; 浅利 貞毅; 海野 倫明; 山上 裕機

  日本外科学会定期学術集会抄録集  2015/04  (一社)日本外科学会
  
• 膵神経内分泌腫瘍における主膵管変化はリンパ節転移の予測因子である

  南野 佳英; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 植田 亜津紗; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会雑誌  2014/10  (一社)日本消化器外科学会
  
• 膵癌術前予後予測因子としてのFDG-PET SUVmaxの有用性

  松本 逸平; 山下 博成; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 南野 佳英; 植田 亜津紗; 松本 拓; 岡崎 太郎; 武部 敦志; 田中 基文; 蔵満 薫; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会雑誌  2014/10  (一社)日本消化器外科学会
  
• 肝移植後長期生着を目指して

  蔵満 薫; 福本 巧; 福島 健司; 木下 秘我; 後藤 直大; 田中 基文; 浅利 貞毅; 武部 敦志; 新関 亮; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会雑誌  2014/10  (一社)日本消化器外科学会
  
• 胆道癌における内視鏡手術の妥当性 胆道癌に対する審査腹腔鏡の有用性

  味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 浅利 貞毅; 後藤 直大; 外山 博近; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  
• 膵頭十二指腸切除術後在院期間の検討  [Not invited]

  後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 南野 佳英; 石田 潤; 木下 秘我; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  
• 抗リン脂質抗体症候群に合併した膵MCNの1手術症例  [Not invited]

  多田羅 敬; 後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 木下 秘我; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  
• 腹腔鏡下膵体尾部切除術施行後に肺血栓塞栓症を発症した一例  [Not invited]

  栗林 真悠; 後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 植田 亜津紗; 南野 佳英; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本臨床外科学会雑誌  2014/10  日本臨床外科学会
  
• 腹腔鏡下尾側膵切除術 導入から術式の定型化・技術認定医取得まで  [Not invited]

  松本 逸平; 外山 博近; 浅利 貞毅; 後藤 直大; 植田 亜津紗; 南野 佳英; 石田 潤; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  
• 膵内視鏡外科の安全性と効率化 腹腔鏡下尾側膵切除術における当科の経験  [Not invited]

  後藤 直大; 松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 南野 佳英; 石田 潤; 蔵満 薫; 松本 拓; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  
• 切除可否の判定に審査腹腔鏡が有用であった化学療法著効後の進行胆嚢癌の一例  [Not invited]

  松本 拓; 味木 徹夫; 村上 冴; 吉田 優子; 篠崎 健太; 蔵満 薫; 後藤 直大; 田中 基文; 武部 敦志; 浅利 貞毅; 木戸 正浩; 外山 博近; 松本 逸平; 福本 巧; 具 英成

  日本内視鏡外科学会雑誌  2014/10  (一社)日本内視鏡外科学会
  
• 膵胆管合流異常症に合併した脈管破格に関する検討

  篠崎 健太; 味木 徹夫; 松本 拓; 吉田 優子; 村上 冴; 岡崎 太郎; 植田 亜津紗; 石田 潤; 南野 佳英; 外山 博近; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  胆道  2014/08  日本胆道学会
  
• 肝外胆管癌における術中迅速診断の役割

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 後藤 直大; 浅利 貞毅; 外山 博近; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  胆道  2014/08  日本胆道学会
  
• 胆道癌切除例における術前胆汁返還の周術期合併症への効果

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  胆道  2014/08  日本胆道学会
  
• 肝転移を伴った大腸癌に対して長期間の化学療法後に手術を施行した肝門部胆管癌の1例

  岡崎 太郎; 味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  胆道  2014/08  日本胆道学会
  
• 十二指腸副乳頭部神経内分泌腫瘍に対する1手術例  [Not invited]

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 南野 佳英; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  胆道  2014/08  日本胆道学会
  
• 神戸大学における劇症肝炎に対する移植プログラム  [Not invited]

  蔵満 薫; 福本 巧; 木戸 正浩; 木下 秘我; 田中 基文; 武部 敦志; 矢野 嘉彦; 三住 拓誉; 後藤 直大; 浅利 貞毅; 外山 博近; 松本 逸平; 味木 徹夫; 具 英成

  日本移植学会総会プログラム抄録集  2014/08  (一社)日本移植学会
  
• 膵腎同時移植後グラフト十二指腸穿孔を生じた1例  [Not invited]

  後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 植田 亜津紗; 南野 佳英; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本移植学会総会プログラム抄録集  2014/08  (一社)日本移植学会
  
• 胆道癌周術期感染症と術前胆道ドレナージの関連性の検討

  岡崎 太郎; 味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 肝切除術におけるリスク評価と治療成績向上に向けた対策 術前・術中肝生検を反映した新たな肝切除術式の立案

  蔵満 薫; 福本 巧; 福島 健司; 木戸 正浩; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 膵頭十二指腸切除術における切離、吻合の工夫 安全・確実な膵空腸再建手術手技

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 肝内胆管癌切除後再発に対する治療方針の検討

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 木戸 正浩; 新関 亮; 松本 逸平; 福本 巧; 寒原 芳浩; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 好中球/リンパ球比はBorderline resectable膵癌根治切除例に対する予後予測因子として有用である

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 味木 徹夫; 岡崎 太郎; 木戸 正浩; 武部 敦志; 福本 巧; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 膵癌術後長期無再発生存例の検討

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 胆道癌根治切除例における術前減黄中胆管炎・膵炎発生の治療成績への影響

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 広範囲胆管癌に対する術前評価と治療戦略 広範囲胆管癌に対する治療法別(切除、化学療法、粒子線)の成績

  味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 癌治療 標準化に向けた試み ガイドラインの検証 膵癌腹腔洗浄細胞診陽性患者に対する切除の意義はあるか?  [Not invited]

  里井 壯平; 元井 冬彦; 上村 健一郎; 川井 学; 倉田 昌直; 庄 雅之; 松本 逸平; 柳本 泰明; 村上 義昭; 胆膵外科研究グループ

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 大腸癌肝転移に対する肝切除後の予後因子の検討  [Not invited]

  木下 秘我; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 進行肝細胞癌に対するPIHPを軸とした集学的治療  [Not invited]

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 肝細胞癌治療における外科手術の位置づけ 腫瘍数4個以上の進行多発肝細胞癌に対する肝切除術の意義  [Not invited]

  武部 敦志; 木戸 正浩; 田中 基文; 蔵満 薫; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 安全な肝切除術を目指して 巨大肝癌に対する肝切除のknack & pitfall  [Not invited]

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 蔵満 薫; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 具 英成

  日本消化器外科学会総会  2014/07  (一社)日本消化器外科学会
  
• 膵癌に対する新たな治療戦略 切除可能膵癌 膵癌切除後早期再発の危険因子と予測スコア

  松本 逸平; 村上 義昭; 川井 学; 元井 冬彦; 上村 健一郎; 庄 雅之; 里井 壯平; 本田 五郎; 新関 亮; 浅利 貞毅; 後藤 直大; 白川 幸代; 石田 潤; 山上 裕機; 海野 倫明; 中島 祥介; 權 雅憲; 倉田 昌直; 福本 巧; 具 英成; 胆膵外科研究グループ

  膵臓  2014/06  (一社)日本膵臓学会
  
• T2胆嚢癌の治療方針 T2胆嚢癌の治療成績の検討

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 後藤 直大; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 胆道癌切除後胆汁瘻の危険因子と治療

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 進行度からみた十二指腸乳頭部癌切除例の検討

  松本 拓; 味木 徹夫; 岡崎 太郎; 村上 冴; 吉田 優子; 篠崎 健太; 蔵満 薫; 後藤 直大; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 膵頭十二指腸切除と尾側膵切除の術後耐糖能の比較検討

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 蔵満 薫; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 黄色肉芽腫性胆嚢炎切除後に遺残胆嚢癌を発症した1例

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 吉田 優子; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 植田 亜津紗; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 胆道癌切除例における胆道再建の工夫

  味木 徹夫; 吉田 優子; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 木戸 正浩; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 膵癌術前予後予測因子としてのFDG-PETの有用性

  松本 逸平; 山下 博成; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 南野 佳英; 植田 亜津紗; 松本 拓; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本癌治療学会誌  2014/06  (一社)日本癌治療学会
  
• 進行胆道癌に対する塩酸ゲムシタビンによる術後補助療法の成績

  味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 松本 逸平; 浅利 貞毅; 後藤 直大; 木戸 正浩; 福本 巧; 具 英成

  日本癌治療学会誌  2014/06  (一社)日本癌治療学会
  
• 膵癌根治切除患者における腹腔洗浄細胞診検査の臨床的意義  [Not invited]

  里井 壯平; 村上 義昭; 元井 冬彦; 川井 学; 倉田 昌直; 庄 雅之; 松本 逸平; 柳本 泰明; 山本 智久; 上村 健一郎; 海野 倫明; 山上 裕機; 本田 五郎; 木下 正一; 新関 亮; 權 雅憲; Multicenter Study Group of Pancreatobiliary Surgery(MSG-PB)

  膵臓  2014/06  日本膵臓学会
  
• 膵頭部癌に対する門脈合併切除は予後を改善するか  [Not invited]

  村上 義昭; 里井 壯平; 上村 健一郎; 元井 冬彦; 川井 学; 本田 五郎; 倉田 昌直; 庄 雅之; 赤堀 宇広; 松本 逸平; 浅利 貞毅; 柳本 泰明; 海野 倫明; 山上 裕機; Multicenter Study Group of Pancreatobiliary Surgery(MSG-PBS)

  膵臓  2014/06  日本膵臓学会
  
• 大動脈周囲リンパ節転移陽性膵癌の手術成績 多施設共同研究822例の解析結果  [Not invited]

  庄 雅之; 村上 義昭; 元井 冬彦; 里井 壮平; 松本 逸平; 川井 学; 本田 五郎; 上村 健一郎; 柳本 泰明; 倉田 昌直; 後藤 直大; 赤堀 宇広; 海野 倫明; 山上 裕機; 中島 祥介; MSG-PBS

  日本癌治療学会誌  2014/06  (一社)日本癌治療学会
  
• Stage 0/I膵癌切除症例の検討  [Not invited]

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 植田 亜津紗; 味木 徹夫; 岡崎 太郎; 松本 拓; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 福本 巧; 具 英成

  膵臓  2014/06  日本膵臓学会
  
• 切離部位に着目した腹腔鏡下尾側膵切除術の要点  [Not invited]

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 南野 佳英; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  膵臓  2014/06  日本膵臓学会
  
• 門脈腫瘍栓(Vp3,4)に対する予後改善への取り組み Vp4門脈腫瘍栓合併肝癌に対するBack Flow Thrombectomy法と経皮的肝灌流化学療法を用いた外科的治療戦略(Surgical treatment for advanced HCC with Vp4 PVTT using Back Flow Thrombectomy and Percutaneous Isolated Hepatic Perfusion)  [Not invited]

  福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 後藤 直大; 浅利 貞毅; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 生体肝移植ドナー肝切除手術における工夫 生体肝移植ドナー肝切除手術における術中超音波胆道造影法  [Not invited]

  浦出 剛史; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 津川 大介; 福島 健司; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• vp1肝細胞癌の術後再発についての検討  [Not invited]

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 津川 大介; 福島 健司; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 後藤 直大; 浦出 剛史; 小松 昇平; 富永 正寛; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 肝細胞癌に対する初回肝切除例における胆汁漏危険因子の解析  [Not invited]

  木下 秘我; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 津川 大介; 後藤 直大; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 肝内胆管癌切除例における切離断端陽性リスクの検討  [Not invited]

  武部 敦志; 味木 徹夫; 吉田 俊彦; 宗 慎一; 福島 健司; 村上 冴; 木下 秘我; 蔵満 薫; 田中 基文; 浅利 貞毅; 岡崎 太郎; 新関 亮; 木戸 正治; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 膵切除における手術手技の工夫 生食滴下式バイポーラを用いた手術手技  [Not invited]

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 南野 佳英; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 術前診断が困難であった膵頭部IPMCの1例  [Not invited]

  南野 佳英; 後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 術前FDG-PETにおける浸潤性膵管癌原発巣SUV値と予後に関する検討  [Not invited]

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 南野 佳英; 植田 亜津紗; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 幽門輪温存膵頭十二指腸切除術と亜全胃温存膵頭十二指腸切除術の短期・長期成績の前向き比較検討  [Not invited]

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 植田 亜津紗; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 術前診断が困難であった膵内副脾Epidermoid cystの1例  [Not invited]

  植田 亜津紗; 新関 亮; 松本 逸平; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 岡崎 太郎; 武部 敦志; 田中 基文; 蔵満 薫; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 膵頭部領域悪性腫瘍患者6例に発生した重症急性膵炎後の膵頭十二指腸切除術の周術期管理について(Perioperative management for pancreatoduodenectomy following severe acute pancreatitis in patients with periampullary tumor: experience with consecutive 6 cases)  [Not invited]

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 味木 徹夫; 岡崎 太郎; 松本 拓; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 肝切除における当科の術前シミュレーションの現状  [Not invited]

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 吉田 俊彦; 岡崎 太郎; 浅利 貞毅; 後藤 直大; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 経皮的冠動脈形成術(PCI)後症例における肝胆膵外科手術  [Not invited]

  新関 亮; 松本 逸平; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 植田 亜津紗; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2014/06  (一社)日本肝胆膵外科学会
  
• 膵癌に対する膵頭十二指腸切除術後左側門脈圧亢進症に対しHassab手術を施行した1例  [Not invited]

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 南野 佳英; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徳夫; 福本 巧; 具 英成

  日本癌治療学会誌  2014/06  (一社)日本癌治療学会
  
• 膵癌早期診断を目指して 早期膵癌診断を目指したIPMN症例における細胞診の工夫  [Not invited]

  Takenaka Mamoru

  膵臓  2014/06
• 生体肝移植後直腸癌とグラフト肝への転移を併発した1例  [Not invited]

  木下 秘我; 福本 巧; 蔵満 薫; 木戸 正浩; 武部 敦志; 田中 基文; 小松 昇平; 松本 逸平; 味木 徹夫; 具 英成

  移植  2014/05  (一社)日本移植学会
  
• ERCP後重症急性膵炎後の膵頭十二指腸切除術例の検討  [Not invited]

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  Gastroenterological Endoscopy  2014/04  (一社)日本消化器内視鏡学会
  
• 当院における分枝型IPMNに対する細胞診の工夫  [Not invited]

  Takenaka Mamoru

  Gastroenterological Endoscopy  2014/04
• 地域医療循環型人材育成プログラムを用いた神戸大学と兵庫県の地域外科医療連携 兵庫県立柏原病院での実践

  味木 徹夫; 大野 伯和; 高瀬 至郎; 中島 高広; 松本 逸平; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• MDCTによる膵頭部癌の膵外神経叢浸潤に関する術前評価基準の検討

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 松本 拓; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 閉塞性黄疸手術例に対する外瘻胆汁返還中の全身・腸管免疫能の動態の解析

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 宇佐美 眞; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 十二指腸乳頭部癌術後早期合併症の検討

  松本 拓; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 膵頭十二指腸切除が膵内分泌機能に及ぼす影響について

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 経乳頭的胆嚢胆汁細胞診の検討

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 浅利 貞毅; 後藤 直大; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 塩見 英之; 増田 充弘; 有坂 好史; 久津見 弘; 具 英成

  日本消化器病学会雑誌  2014/03  (一財)日本消化器病学会
  
• 非切除進行、再発胆道癌に対するGEM、S-1段階的治療の成績

  味木 徹夫; 岡崎 太郎; 村上 冴; 吉田 優子; 篠崎 健太; 松本 拓; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 木戸 正浩; 福本 巧; 豊田 昌徳; 具 英成

  日本消化器病学会雑誌  2014/03  (一財)日本消化器病学会
  
• 肝細胞癌vp1症例術後再発形式の検討  [Not invited]

  小松 昇平; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 福島 健司; 浦出 剛史; 宗 慎一; 松本 逸平; 味木 徹夫; 千堂 宏義; 杉本 武巳; 藤野 泰宏; 富永 正寛; 具 英成

  新薬と臨牀  2014/03  (株)医薬情報研究所
  
• 肝静脈根部大型肝癌に対する肝切除術式の工夫 腫瘍栓合併肝静脈根部大型肝癌に対する外科治療  [Not invited]

  福本 巧; 木戸 正浩; 武部 敦; 田中 基文; 蔵満 薫; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 神戸大学におけるポジティブアクションプログラム  [Not invited]

  蔵満 薫; 福本 巧; 木戸 正浩; 木下 秘我; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 膵切除術における周術期管理  [Not invited]

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 膵神経内分泌腫瘍(PNET)の転移に関わる因子の検討  [Not invited]

  南野 佳英; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 新臨床研修制度導入後の外科医育成の取り組み  [Not invited]

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 術前胆道ドレナージを要した胆道癌における周術期感染症の検討  [Not invited]

  岡崎 太郎; 味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 蔵満 薫; 田中 基文; 浅利 貞毅; 武部 敦志; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 進行多発肝細胞癌に対する外科治療の役割  [Not invited]

  武部 敦志; 福本 巧; 木戸 正浩; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健二; 浦出 剛史; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 貝 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 良低悪性度腫瘍に対する腹腔鏡下膵体尾部切除術  [Not invited]

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 膵腫瘍核出術における内視鏡下膵管ステントの適応  [Not invited]

  新関 亮; 松本 逸平; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 後藤 直大; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 末期肝硬変患者における副腎機能評価の検討  [Not invited]

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本外科学会雑誌  2014/03  (一社)日本外科学会
  
• 膵癌術後補助化学療法の完遂予測因子の検討  [Not invited]

  後藤 直大; 松本 逸平; 田中 正樹; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器病学会雑誌  2014/03  (一財)日本消化器病学会
  
• 肝移植後長期生着を目指して  [Not invited]

  蔵満 薫; 福本 巧; 木戸 正浩; 木下 秘我; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器病学会雑誌  2014/03  (一財)日本消化器病学会
  
• 膵癌との鑑別を要した自己免疫性膵炎の検討 外科医が経験した9例  [Not invited]

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 味木 徹夫; 岡崎 太郎; 松本 拓; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 福本 巧; 具 英成

  日本消化器病学会雑誌  2014/03  (一財)日本消化器病学会
  
• 手術例から観たIPMN由来浸潤癌の予後予測因子の検討  [Not invited]

  Takenaka Mamoru

  日本消化器病学会雑誌  2014/03
• 肝門部悪性胆道狭窄に対する術前減黄中胆管炎発症例の検討

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本腹部救急医学会雑誌  2014/02  (一社)日本腹部救急医学会
  
• 膵中央切除術後膵腸縫合不全に対し緊急手術を施行した1例

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 田中 正樹; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本腹部救急医学会雑誌  2014/02  (一社)日本腹部救急医学会
  
• 亜全胃温存膵頭十二指腸切除術後5ヵ月で胃空腸吻合部の穿孔により腹膜炎をきたした1例

  松本 拓; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 蔵満 薫; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本腹部救急医学会雑誌  2014/02  (一社)日本腹部救急医学会
  
• 3cm、3個以下の肝細胞癌に対する肝切除、生体肝移植の治療成績

  福島 健司; 木戸 正浩; 福本 巧; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 浦出 剛史; 宗 慎一; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会雑誌  2013/10  (一社)日本消化器外科学会
  
• 腹部固形癌に対する粒子線とスペーサー外科手術を用いた治療限界の克服

  木下 秘我; 福本 巧; 宗 慎一; 浦出 剛史; 福島 健司; 中馬 正志; 小松 昇平; 蔵満 薫; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会雑誌  2013/10  (一社)日本消化器外科学会
  
• 吻合、再建の手術手技(膵臓) 膵頭十二指腸切除術における安全、確実な膵空腸再建手術手技

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  
• 臓器移植の現状と問題点 臓器移植法改正後の肝移植の現況

  武部 敦志; 福本 巧; 木戸 正治; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 浦出 剛史; 福島 健司; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  
• 再発癌の治療戦略(肝・胆・膵) 残膵癌に対する治療戦略  [Not invited]

  石田 潤; Matsumoto Ippei; Asari Sadaki; Goto Tadahiro; 田中 正樹; 山下 博成; 味木 徹夫; 福本 巧; Ku Yonson

  日本臨床外科学会雑誌  2013/10  日本臨床外科学会
  
• 非切除進行・再発胆道癌に対する2次治療としてのS-1投与の役割

  味木 徹夫; 岡崎 太郎; 村上 冴; 吉田 優子; 篠崎 健太; 松本 拓; 松本 逸平; 新関 亮; 浅利 貞毅; 木戸 正浩; 福本 巧; 具 英成

  日本癌治療学会誌  2013/09  (一社)日本癌治療学会
  
• 進行肝細胞癌に対する新しい治療戦略  [Not invited]

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 具 英成

  日本癌治療学会誌  2013/09  (一社)日本癌治療学会
  
• 膵癌切除後早期再発の危険因子  [Not invited]

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本癌治療学会誌  2013/09  (一社)日本癌治療学会
  
• 高濃度Cisplatinを用いた肝動注療法の実現に向けた動物モデルの構築と基礎検討  [Not invited]

  武部 敦志; 福本 巧; 木戸 正浩; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昌平; 福島 健司; 浦出 剛史; 宗 慎一; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本癌治療学会誌  2013/09  (一社)日本癌治療学会
  
• 膵癌術後補助化学療法における血清アルブミン値の重要性  [Not invited]

  後藤 直大; 松本 逸平; 田中 正樹; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本癌治療学会誌  2013/09  (一社)日本癌治療学会
  
• 胆嚢癌切除後経過中に遺残膵内胆管癌を発症した膵・胆管合流異常の一例  [Not invited]

  松本 拓; 篠崎 健太; 吉田 優子; 村上 冴; 岡崎 太郎; Goto Tadahiro; Asari Sadaki; 新関 亮; 木戸 正浩; Matsumoto Ippei; 味木 徹夫; 福本 巧; 具 英成

  日本膵・胆管合流異常研究会プロシーディングス  2013/09  日本膵・胆管合流異常研究会
  
• MUC染色による混合型IPMNにおけるhigh risk群の抽出 International consensus guideline 2012を踏まえて  [Not invited]

  竹中 完; 松木 信之; 塩見 英之; 増田 充弘; 有坂 好史; 久津見 弘; 早雲 孝信; 東 健; Matsumoto Ippei; Ku Yonson; Hara Shigeo; 伊藤 智雄

  日本消化器病学会雑誌  2013/09
• 胆道癌非切除例に対する集学的治療(抗癌剤、粒子線治療)の成績

  味木 徹夫; 岡崎 太郎; 村上 冴; 松本 拓; 吉田 優子; 篠崎 健太; 新関 亮; 松本 逸平; 木戸 正浩; 福本 巧; 寺島 千貴; 不和 信和; 豊田 昌徳; 具 英成

  胆道  2013/08  日本胆道学会
  
• 胆管内乳頭状腫瘍(IPNB)自験例6例の検討

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 吉田 優子; 村上 冴; 松本 拓; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  胆道  2013/08  日本胆道学会
  
• 肝移植後長期合併症の管理  [Not invited]

  蔵満 薫; 福本 巧; 木戸 正浩; 福島 健司; 小松 昇平; 木下 秘我; 田中 基文; 武部 敦志; 松本 逸平; 味木 徹夫; 具 英成

  移植  2013/08  (一社)日本移植学会
  
• 膵切除後の短期・長期合併症に対する予防策とその根拠 尾側膵切除後の新規糖尿病発症予測因子としての膵切除量の検討

  白川 幸代; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 胆道癌におけるERC下細胞診および生検の有用性

  村上 冴; 味木 徹夫; 岡崎 太郎; 大坪 出; 吉田 優子; 篠崎 健太; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• IPMNに対する縮小手術の適応

  新関 亮; 松本 逸平; 浅利 貞毅; 後藤 直大; 椋棒 英世; 白川 幸代; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 心血管疾患に対する抗凝固療法加療例における胆嚢摘出術の検討

  大坪 出; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 肝門部胆管癌の肝側胆管切離線決定における3D-CT胆管像の有用性

  味木 徹夫; 岡崎 太郎; 大坪 出; 吉田 優子; 村上 冴; 篠崎 健太; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 膵切除後腹腔内出血に対する治療戦略

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 椋棒 英世; 田中 正樹; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 腹腔動脈幹合併膵体尾部切除術後の仮性動脈瘤出血に対して、TAEと開腹ドレナージにより救命した一例

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 石田 潤; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 上中部胆管癌に対する胆管切除術の成績

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 大坪 出; 村上 冴; 吉田 優子; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 膵癌長期生存例の検討

  田中 正樹; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 大動脈周囲リンパ節陽性胆管癌の切除成績

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 大坪 出; 村上 冴; 吉田 優子; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 腎癌膵転移に対して二度の膵切除を行った一例 当科における腎癌膵転移症例の検討

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 岩崎 寿光; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 胆道再建術後の胆道再々建術施行例の検討

  吉田 優子; 味木 徹夫; 岡崎 太郎; 大坪 出; 村上 冴; 篠崎 健太; 蔵満 薫; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 新たな術前肝予備能評価法とその臨床応用 肝右葉切除の術前評価における99mTc-GSAシンチグラフィーの有用性について  [Not invited]

  田中 基文; 木戸 正浩; 高橋 応典; 武部 敦志; 蔵満 薫; 福島 健司; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 次世代に向けた消化器外科におけるNavigation Surgery 細胞標識、画像応用を含めて ソナゾイド術中超音波下胆道造影を用いた肝胆道ナビゲーション手術  [Not invited]

  浦出 剛史; 田中 基文; 福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 蔵満 薫; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 肝切除における合併症予防策  [Not invited]

  木戸 正浩; 福本 巧; 高橋 応典; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 味木 徹夫; 松本 逸平; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 3cm、3個以下の肝細胞癌に対する肝切除、生体肝移植の治療成績  [Not invited]

  福島 健司; 木戸 正浩; 福本 巧; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 進行・再発肝細胞癌に対する治療戦略 超進行肝癌に対するPIHPを基軸とした治療戦略 Back Flow Perfusion法と3段階治療の役割  [Not invited]

  福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2013/07  (一社)日本消化器外科学会
  
• 中部胆管癌に対する胆管切除術後6ヵ月で発症した下部胆管癌の1切除例

  村上 冴; 味木 徹夫; 岡崎 太郎; 大坪 出; 吉田 優子; 篠崎 健太; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 癌幹細胞マーカーCD133の発現からみたIPNBと膵IPMNの類似性

  味木 徹夫; 村上 冴; 岡崎 太郎; 大坪 出; 吉田 優子; 篠崎 健太; 堀 裕一; 松本 逸平; 新関 亮; 木戸 正浩; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 術前胆道ドレナージ症例における術後胆管炎の検討

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 大坪 出; 村上 冴; 吉田 優子; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 肝切離術の工夫 当科での肝癌に対する肝切除の工夫  [Not invited]

  福島 健司; 木戸 正浩; 福本 巧; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 中馬 正志; 浦出 剛史; 宋 慎一; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 肝胆膵外科手術への術前シミュレーションサージェリーの応用 肝胆道外科領域における当科の術前シミュレーションの取り組み  [Not invited]

  田中 基文; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 浦出 剛史; 松本 逸平; 味木 徹夫; 福本 巧; 杉本 真樹; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 肝癌診療ガイドライン2009に基づく治療成績 肝癌診療ガイドラインを越えた肝細胞癌治療の現況  [Not invited]

  小松 昇平; 福本 巧; 木下 秘我; 蔵満 薫; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 寺嶋 千貴; 藤井 収; 出水 祐介; 不破 信和; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 非B非C肝炎肝癌の外科的治療成績 神戸大学における非B非C肝癌の外科的治療成績  [Not invited]

  武部 敦志; 福本 巧; 木戸 正治; 田中 基文; 蔵満 薫; 福島 健司; 浦出 剛史; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 生体肝移植の手術手技の工夫 高度門脈血栓合併症例に対する門脈再建術の工夫  [Not invited]

  蔵満 薫; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 木下 秘我; 小松 昇平; 松本 逸平; 味木 徹夫; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 肝細胞癌多発肺転移、リンパ節転移に対し集学的治療を行い、長期生存を得た1例  [Not invited]

  木下 秘我; 木戸 正浩; 宗 慎一; 浦出 剛史; 福島 健司; 中馬 正志; 小松 昇平; 蔵満 薫; 田中 基文; 武部 敦志; 高橋 応典; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本肝胆膵外科学会・学術集会プログラム・抄録集  2013/06  (一社)日本肝胆膵外科学会
  
• 粘液産生胆管腫瘍(IPNB)からの細胞株樹立

  村上 冴; 味木 徹夫; 堀 裕一; 篠崎 健太; 吉田 優子; 大坪 出; 岡崎 太郎; 松本 逸平; 福本 巧; 具 英成

  日本外科学会雑誌  2013/03  (一社)日本外科学会
  
• 外科的治療限界の克服 スペーサー手術と粒子線治療の融合  [Not invited]

  高橋 応典; 福本 巧; 木戸 正浩; 武部 敦史; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 中馬 正志; 福島 健司; 浦出 剛史; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 出水 祐介; 寺嶋 千貴; 不破 信和; 具 英成

  日本外科学会雑誌  2013/03  (一社)日本外科学会
  
• 高度門脈血栓合併症例に対する門脈再建術  [Not invited]

  蔵満 薫; 福本 巧; 福島 健司; 宗 慎一; 浦出 剛史; 中馬 正志; 小松 昇平; 木下 秘我; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成

  日本外科学会雑誌  2013/03  (一社)日本外科学会
  
• 肝細胞癌患者におけるPHLFの検討 新たな肝予備能評価方法の立案にむけて  [Not invited]

  福島 健司; 蔵満 薫; 福本 巧; 浦出 剛史; 中馬 正志; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成

  日本外科学会雑誌  2013/03  (一社)日本外科学会
  
• 80歳以上の高齢者における肝細胞癌切除例の検討  [Not invited]

  田中 基文; 福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 中馬 正志; 浦出 剛史; 宋 慎一; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成

  日本外科学会雑誌  2013/03  (一社)日本外科学会
  
• 肝移植医療のさらなる普及と脳死移植発展のために今必要とされること 市中病院および移植施設における移植外科医の役割  [Not invited]

  武部 敦志; 福本 巧; 木戸 正治; 高橋 応典; 田中 基文; 蔵満 薫; 中馬 正志; 福島 健司; 浦出 剛史; 新関 亮; 松本 逸平; 味木 徹夫; 豊川 晃弘; 岩崎 武; 具 英成

  日本外科学会雑誌  2013/03  (一社)日本外科学会
  
• 肝胆膵領域の内視鏡的治療の実際 Roux-Y胆道再建術後症例に対するダブルバルーン内視鏡の有用性

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 吉田 優子; 村上 冴; 大坪 出; 上野 公彦; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本腹部救急医学会雑誌  2013/02  (一社)日本腹部救急医学会
  
• 術前胆管炎コントロールに難渋した肝門部胆管癌の一切除例

  大坪 出; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 後藤 直大; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成

  日本腹部救急医学会雑誌  2013/02  (一社)日本腹部救急医学会
  
• 術前経皮的肝灌流と肝切除で完全奏効した両葉多発肝細胞癌の1例  [Not invited]

  Takebe Atsushi; Fukumoto Takumi; Kito Masahiro; tsutida Shinobu; Takahashi Masanori; Tanaka Motofumi; Kuramitsu Kaori; Toyama Hirochika; Shinzeki Makoto; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  新薬と臨床  2012/12  (株)医薬情報研究所
  
• 腹腔鏡下尾側膵切除術 導入と術式の定型化へ向けて  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Takebe Atsushi; Takahashi Masanori; Okazaki Taro; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌  2012/12  (一社)日本内視鏡外科学会
  
• 腹腔鏡下尾側膵切除術における術中出血への対策  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Okazaki Taro; Takahashi Masanori; Takebe Atsushi; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌  2012/12  (一社)日本内視鏡外科学会
  
• 低侵襲手術ナビゲーション最前線 Virtual 3D画像と臓器立体モデル 肝臓外科領域における当科の術前シミュレーション・術中ナビゲーションの取り組み  [Not invited]

  Tanaka Motofumi; Sugimoto Maki; Ajiki Tetsuo; Matsumoto Ippei; Kito Masahiro; Shinzeki Makoto; Takahashi Masanori; Asari Sadaki; Takebe Atsushi; Kuramitsu Kaori; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌  2012/12  (一社)日本内視鏡外科学会
  
• 肝硬変症例に対する腹腔鏡下胆嚢摘出術の成績  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本内視鏡外科学会雑誌  2012/12  (一社)日本内視鏡外科学会
  
• 細径膵管例における確実な膵空腸吻合手術手技  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Okazaki Taro; Takahashi Masanori; Takebe Atsushi; Kito Masahiro; Fukumoto Takumi; Ajiki Tetsuo; Ku Yonson

  日本臨床外科学会雑誌  2012/10
• 膵癌の診断・治療方針決定におけるFDG-PETの有用性の検討  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Okazaki Taro; Takahashi Masanori; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本癌治療学会誌  2012/10
• 門脈腫瘍栓(Vp4)合併肝細胞癌に対する肝切除の工夫と集学的治療としてのPIHPの有効性  [Not invited]

  Tanaka Motofumi; Kito Masahiro; Kusunoki Nobuya; Takahashi Masanori; Takebe Atsushi; Kuramitsu Kaori; Shinzeki Makoto; Matsumoto Ippei; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10  日本臨床外科学会
  
• ソナゾイドによる術中超音波胆道造影を用いた肝切除術  [Not invited]

  Fukumoto Takumi; Kito Masahiro; Takahashi Masanori; Takebe Atsushi; Tanaka Motofumi; Kuramitsu Kaori; Shinzeki Makoto; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  日本臨床外科学会雑誌  2012/10  日本臨床外科学会
  
• Hanging maneuverを用いた巨大肝細胞癌に対する安全な肝右肝切除術  [Not invited]

  Takebe Atsushi; Fukumoto Takumi; Takahashi Masanori; Tanaka Motofumi; Ajiki Tetsuo; Matsumoto Ippei; Shinzeki Makoto; Ku Yonson

  日本臨床外科学会雑誌  2012/10  日本臨床外科学会
  
• 膵切除における手術手技の工夫(生食滴下式バイポーラを用いた手術手技)  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Takebe Atsushi; Takahashi Masanori; Okazaki Taro; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10
• 膵癌鑑別診断および術前診断におけるFDG-PETの位置づけ  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Okazaki Taro; Takahashi Masanori; Takebe Atsushi; Kito Masahiro; Fukumoto Takumi; Ajiki Tetsuo

  日本臨床外科学会雑誌  2012/10
• 腹腔鏡下膵切除術 腹腔鏡下尾側膵切除術 安全な術式の定型化  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Takebe Atsushi; Takahashi Masanori; Okazaki Taro; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10  日本臨床外科学会
  
• 当院における単孔式腹腔鏡下胆嚢摘出術の成績  [Not invited]

  Okazaki Taro; Ajiki Tetsuo; Asari Sadaki; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10
• 胆嚢癌との鑑別診断が困難であった黄色肉芽腫性胆嚢炎の1例  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10  日本臨床外科学会
  
• 切除断端、断端距離から見た肝内胆管癌の手術戦略  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10
• 集学的治療により長期生存を得ている大動脈周囲リンパ節転移陽性胆管癌の1例  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本癌治療学会誌  2012/10
• 主膵管型IPMNに対する術前診断と術式選択  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10
• Hepatomesenteric typeの肝動脈走行変異を伴う十二指腸乳頭部癌に対してSSPPDを施行した1例  [Not invited]

  Ajiki Tetsuo; Asari Sadaki; Okazaki Taro; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10
• 肝門部胆管癌の術前診断で切除したIgG4関連硬化性胆管炎の1例  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Takahashi Masanori; Shinzeki Makoto; Matsumoto Ippei; Kito Masahiro; Hara Shigeo; Fukumoto Takumi; Ku Yonson

  日本臨床外科学会雑誌  2012/10
• 膵癌に対する陽子線治療効果判定におけるFDG-PETの有用性  [Not invited]

  Matsumoto Ippei; Toyama Hirochika; Shinzeki Makoto; Asari Sadaki; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本消化器病学会雑誌  2012/09
• 門脈血栓症を合併した症例に対する門脈再建術の検討  [Not invited]

  Kuramitsu Kaori; Fukumoto Takumi; Tanaka Motofumi; Takebe Atsushi; Takahashi Masanori; Kito Masahiro; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  移植  2012/09
• 局所進行膵癌に対する治療戦略 陽子線治療を用いた局所進行膵癌に対する新規治療戦略  [Not invited]

  Matsumoto Ippei; Ku Yonson

  日本消化器病学会雑誌  2012/09  (一財)日本消化器病学会
  
• 非拡張型膵・胆管合流異常に肝門部胆管癌、胆嚢癌の重複癌を合併した一例  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Asari Sadaki; Matsumoto Ippei; Shinzeki Makoto; Kito Masahiro; Fukumoto Takumi; Ku Yonson

  日本膵・胆管合流異常研究会プロシーディングス  2012/09
• グラフト脾動脈・上腸間膜動脈血栓をきたした膵腎同時移植の1生着例  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Kito Masahiro; Fukumoto Takumi; Ku Yonson

  移植  2012/09
• 早期乳頭部癌の臨床的特徴と治療  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Ueno Kimihiko; Matsumoto Ippei; Fukumoto Takumi; Shiomi Hideyuki; Masuda Atsuhiro; Kutsumi Hiromu; Ku Yonson

  胆道  2012/08
• 肝外胆管癌に対する肝外胆管切除術の成績  [Not invited]

  Ajiki Tetsuo; Okazaki Taro; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  胆道  2012/08
• 当科におけるpT2胆嚢癌に対する術式の検討

  沢 秀博; 味木 徹夫; 上野 公彦; 大坪 出; 吉田 優子; 新関 亮; 外山 博近; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• IPMNの術式選択とその妥当性 IPMNに対する縮小手術の適応

  新関 亮; 松本 逸平; 外山 博近; 後藤 直大; 浅利 真毅; 木戸 正浩; 上野 公彦; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 膵胆管合流異常症に対する至適術式の検討

  上野 公彦; 味木 徹夫; 沢 秀博; 大坪 出; 篠崎 健太; 外山 博近; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 超高齢者に対する治療選択の理想と現実(胆膵悪性腫瘍) 80歳以上超高齢者胆道癌に対する治療成績の検討

  篠崎 健太; 味木 徹夫; 上野 公彦; 沢 秀博; 村上 冴; 新関 亮; 外山 博近; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 乳頭部癌再発症例の検討

  大坪 出; 味木 徹夫; 上野 公彦; 吉田 優子; 沢 秀博; 外山 博近; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 胆嚢癌疑診例に対する胆嚢内胆汁細胞診の有用性

  村上 冴; 味木 徹夫; 沢 秀博; 上野 公彦; 吉田 優子; 新関 亮; 外山 博近; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 消化器外科領域におけるステント療法の役割 閉塞性黄疸を伴う胆道癌患者における術前減黄法の比較

  吉田 優子; 味木 徹夫; 上野 公彦; 沢 秀博; 篠崎 健太; 外山 博近; 新関 亮; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 胆管癌のborderline resectable症例の定義と対策 肝門部胆管癌における胆管断端癌遺残例はborderline resectable症例である

  味木 徹夫; 上野 公彦; 沢 秀博; 篠崎 健太; 村上 冴; 新関 亮; 外山 博近; 松本 逸平; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 鏡視下手術用臓器圧排器具エンドラクターの腹腔鏡下肝切除術における有用性  [Not invited]

  土田 忍; 福本 巧; 楠 信也; 木戸 正浩; 高橋 応典; 田中 基文; 松本 逸平; 味木 徹夫; 濱口 武之; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 進行再発肝癌に対する治療戦略  [Not invited]

  木戸 正浩; 福本 巧; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 味木 徹夫; 松本 逸平; 新関 亮; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 肝機能からみた肝細胞癌に対する治療戦略 肝癌根治的治療域の拡大 幕内基準を超えた肝切除の可能性  [Not invited]

  福本 巧; 木戸 正浩; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 肝障害の少ない肝切除の工夫と周術期管理 左葉を用いた成人生体肝移植における残肝還流障害を回避可能な術式選択  [Not invited]

  蔵満 薫; 福本 巧; 福島 健司; 田中 基文; 高橋 応典; 木戸 正浩; 土田 忍; 松本 逸平; 味木 徹夫; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 肝胆道手術における術前シミュレーションと術中ナビゲーションの取り組み  [Not invited]

  田中 基文; 杉本 真樹; 上野 公彦; 木戸 正浩; 外山 博近; 新関 亮; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成

  日本消化器外科学会総会  2012/07  (一社)日本消化器外科学会
  
• 膵・胆管合流異常を伴わない20代の肝門部胆管癌の一切除例  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Matsumoto Ippei; tsutida Shinobu; Shinzeki Makoto; Toyama Hirochika; Kito Masahiro; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 脳死下膵腎同時移植における血行再建術  [Not invited]

  Asari Sadaki; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Ajiki Tetsuo; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 肉腫成分を含む肝内胆管癌および混合型肝癌の2例  [Not invited]

  Kito Masahiro; Fukumoto Takumi; tsutida Shinobu; Tanaka Motofumi; Kuramitsu Kaori; Ajiki Tetsuo; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Kawakami Fumi; Itoh Tomoo; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05  (一社)日本肝胆膵外科学会
  
• 当施設におけるmodified Hanging Maneuverを用いた肝葉切除の工夫  [Not invited]

  Kito Masahiro; Fukumoto Takumi; tsutida Shinobu; Tanaka Motofumi; Kuramitsu Kaori; Ajiki Tetsuo; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05  (一社)日本肝胆膵外科学会
  
• 胆道再々建術施行例の背景疾患と手術成績の検討  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Shinzeki Makoto; Toyama Hirochika; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 心血管疾患合併患者の胆嚢摘出術例の検討  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Toyama Hirochika; Shinzeki Makoto; Matsumoto Ippei; Kito Masahiro; tsutida Shinobu; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 肝胆膵領域の外科治療 これまでの到達点、これからの課題 肝門部胆管癌の切除方法 脈管合併切除とアプローチ 肝門部胆管癌門脈合併切除例の検討  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Kito Masahiro; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 肝切除における残肝体積と予備能のコンセンサス再考 肝細胞癌における術式選択 幕内基準を超えて  [Not invited]

  Fukumoto Takumi; Kuramitsu Kaori; Tanaka Motofumi; Takahashi Masanori; Kito Masahiro; tsutida Shinobu; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05  (一社)日本肝胆膵外科学会
  
• 膵切除の合併症とその対処法 膵頭十二指腸切除術後出血例に対する治療選択と成績  [Not invited]

  Matsumoto Ippei; Toyama Hirochika; Shinzeki Makoto; Asari Sadaki; Takahashi Masanori; Ueno Kimihiko; tsutida Shinobu; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  膵臓  2012/05
• 膵腫瘍核手術 手技の工夫と術後膵機能  [Not invited]

  Matsumoto Ippei; Toyama Hirochika; Shinzeki Makoto; Asari Sadaki; Ueno Kimihiko; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 膵腫瘍に対する鏡視下尾側膵切除術  [Not invited]

  Shinzeki Makoto; Matsumoto Ippei; Toyama Hirochika; Asari Sadaki; Takahashi Masanori; Kito Masahiro; tsutida Shinobu; Ueno Kimihiko; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 膵空腸吻合法 膵頭十二指腸切除術における安全・確実な膵空腸吻合手術手技  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Takahashi Masanori; Ueno Kimihiko; tsutida Shinobu; Kito Masahiro; Kusunoki Nobuya; Fukumoto Takumi; Ajiki Tetsuo; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 膵癌術後5年目に出現した超高齢者の残膵癌に対し、粒子線治療を施行した一例  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Ueno Kimihiko; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Fukumoto Takumi; Ajiki Tetsuo; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 腹腔鏡下膵手術の現況 膵腫瘍に対する腹腔鏡下尾側膵切除術  [Not invited]

  Shinzeki Makoto; Matsumoto Ippei; Toyama Hirochika; Asari Sadaki; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  膵臓  2012/05
• 腹腔鏡下ラジオ波焼灼術におけるNon Trocar Techniqueの有用性  [Not invited]

  tsutida Shinobu; Fukumoto Takumi; Ajiki Tetsuo; Kusunoki Nobuya; Matsumoto Ippei; Kito Masahiro; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Takahashi Masanori; Asari Sadaki; Tanaka Motofumi; Kuramitsu Kaori; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05  (一社)日本肝胆膵外科学会
  
• 胆嚢と総胆管の内視鏡外科 Lap-Cのpit fallと対策 腹腔鏡下胆嚢摘出術における術中胆道損傷例の特徴とその対処に関する検討  [Invited]

  Ueno Kimihiko; Ajiki Tetsuo; Asari Sadaki; Toyama Hirochika; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• 切除例の解析からみたIPMNの治療戦略  [Not invited]

  Toyama Hirochika; Matsumoto Ippei; Shinzeki Makoto; Asari Sadaki; Ajiki Tetsuo; Ueno Kimihiko; Kito Masahiro; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• TNM分類と腫瘍細胞増殖動態からみた膵神経内分泌腫瘍(P-NET)術後再発例の検討  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Ueno Kimihiko; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  膵臓  2012/05
• Stage 0ならびにStage I膵癌切除症例の検討  [Not invited]

  Asari Sadaki; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Ueno Kimihiko; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  膵臓  2012/05
• Borderline resectable膵癌切除例の検討と今後の展望  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Ueno Kimihiko; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• CT所見とERC/IDUS所見の乖離により診断に難渋した進行胆嚢癌疑いの1例  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Hara Shigeo; Itoh Tomoo; Ku Yonson

  日本肝胆膵外科学会・学術集会プログラム・抄録集24回  2012/05
• EPSガイド下に腫瘍核出術を施行し得た膵頭部Solid-pseudopapillary neoplasmの1例  [Not invited]

  Asari Sadaki; Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Kito Masahiro; Kusunoki Nobuya; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  超音波医学  2012/04
• 膵管内発育を呈した膵原発癌肉腫の一例  [Not invited]

  Shiomi Hideyuki; Masuda Atsuhiro; Sugimoto Maki; Kutsumi Hiromu; Hayakumo Takanobu; Shinzeki Makoto; Matsumoto Ippei; Ku Yonson; Hara Shigeo; Itoh Tomoo; Azuma Takeshi

  Gastroenterological Endoscopy  2012/04
• HLA0ミスマッチドナーからの膵腎同時移植後GVHDの経験  [Not invited]

  Takeda Masashi; Toyama Hirochika; Ishimura Takeshi; Miyake Hideaki; Tanaka Kazushi; Matsumoto Ippei; Fujisawa Masato

  日本泌尿器科学会雑誌  2012/03
• IPMN外科治療における縮小手術の位置づけ  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Takahashi Masanori; Ueno Kimihiko; tsutida Shinobu; Kito Masahiro; Kusunoki Nobuya; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本消化器病学会雑誌  2012/03
• 代謝酵素測定による胆道癌術後GEM補助投与の効果予測の検討  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Shinzeki Makoto; Toyama Hirochika; Kito Masahiro; Matsumoto Ippei; Kusunoki Nobuya; Fukumoto Takumi; Hori Yuichi; Ku Yonson

  日本外科学会雑誌  2012/03
• 生体肝移植後腎機能障害に対する予測式を用いた新たな治療戦略  [Not invited]

  Kuramitsu Kaori; Fukumoto Takumi; Tanaka Motofumi; Takahashi Masanori; Kito Masahiro; tsutida Shinobu; Matsumoto Ippei; Ajiki Tetsuo; Ku Yonson

  日本外科学会雑誌  2012/03  (一社)日本外科学会
  
• 肝細胞癌の治療戦略 その進歩と今後の方向性 高度進行肝癌に対する減量肝切除とPIHPによる2段階治療の有効性と予後因子の解析  [Not invited]

  Fukumoto Takumi; Kito Masahiro; tsutida Shinobu; Takahashi Masanori; Tanaka Motofumi; Kuramitsu Kaori; Ueno Kimihiko; Toyama Hirochika; Shinzeki Makoto; Matsumoto Ippei; Kusunoki Nobuya; Ajiki Tetsuo; Ku Yonson

  日本外科学会雑誌  2012/03  (一社)日本外科学会
  
• 化学療法の進歩に伴う進行膵胆道癌の手術適応 非切除胆道癌に対し化学療法施行後に切除に至った症例の検討  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Kito Masahiro; Shinzeki Makoto; Toyama Hirochika; Matsumoto Ippei; Hori Yuichi; Fukumoto Takumi; Ku Yonson

  日本外科学会雑誌  2012/03
• 膵癌術後補助化学療法の再検討と課題  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Takahashi Masanori; Ueno Kimihiko; tsutida Shinobu; Kito Masahiro; Kusunoki Nobuya; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本外科学会雑誌  2012/03
• 尾側膵切除後糖尿病の危険因子の解析  [Not invited]

  Matsumoto Ippei; Toyama Hirochika; Shinzeki Makoto; Asari Sadaki; Ueno Kimihiko; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Kusunoki Nobuya; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本外科学会雑誌  2012/03
• 中上部胆管癌に対する胆管切除の検討  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Asari Sadaki; Takahashi Masanori; Shinzeki Makoto; Toyama Hirochika; Kito Masahiro; Matsumoto Ippei; tsutida Shinobu; Kusunoki Nobuya; Fukumoto Takumi; Ku Yonson

  日本外科学会雑誌  2012/03
• 胆嚢摘出時における術中胆道造影の意義  [Not invited]

  Ueno Kimihiko; Ajiki Tetsuo; Asari Sadaki; Toyama Hirochika; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本外科学会雑誌  2012/03
• 主膵管近接腫瘍に対する膵腫瘍核出術の適応と手術手技の工夫  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Ueno Kimihiko; Takahashi Masanori; tsutida Shinobu; Kito Masahiro; Kusunoki Nobuya; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本外科学会雑誌  2012/03
• 腸回転異常症に伴う回盲部軸捻転の1例  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Toyama Hirochika; Shinzeki Makoto; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本腹部救急医学会雑誌  2012/02
• 抗凝固薬内服患者に対する腹腔鏡下胆嚢摘出術施行例の検討  [Not invited]

  Ajiki Tetsuo; Ueno Kimihiko; Shinzeki Makoto; Toyama Hirochika; Kito Masahiro; Matsumoto Ippei; Fukumoto Takumi; Ku Yonson

  日本腹部救急医学会雑誌  2012/02
• 急性胆嚢炎、胆汁性腹膜炎の術前診断で緊急手術を施行したうっ血性肝障害の1例  [Not invited]

  Matsumoto Ippei; Kito Masahiro; tsutida Shinobu; Shinzeki Makoto; Toyama Hirochika; Takahashi Masanori; Ueno Kimihiko; Kusunoki Nobuya; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson

  日本腹部救急医学会雑誌  2012/02
• 肝門部胆管癌術後仮性動脈瘤出血の1例  [Not invited]

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Asari Sadaki; Takahashi Masanori; Ueno Kimihiko; tsutida Shinobu; Kito Masahiro; Kusunoki Nobuya; Fukumoto Takumi; Ajiki Tetsuo; Ku Yonson

  日本腹部救急医学会雑誌  2012/02
• 術中胆道造影からみた膵液胆管逆流現象についての検討  [Not invited]

  藤田恒憲; AJIKI, Tetsuo; 松本逸平; 堀宏成; 美田良保; 松本拓; UEDA, Takashi; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  日本消化器外科学会雑誌  2005/07  一般社団法人日本消化器外科学会
  
• 消化器癌化学療法の最適化をめぐって 基礎的データに基づいた胆道癌に対する新規抗癌剤投与とその実際  [Not invited]

  AJIKI, Tetsuo; 高瀬至郎; KAMIGAKI, Takashi; 藤田恒憲; 美田良保; 堀宏成; 松本逸平; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; KURODA, Yoshikazu

  日本消化器外科学会雑誌  2005/07  一般社団法人日本消化器外科学会
  
• 浸潤性膵管癌に対するGemcitabineを用いた膵動注・肝動注療法  [Not invited]

  FUJINO, Yasuhiro; SUZUKI, Yasuyuki; 吉川卓郎; KAMIGAKI, Takashi; AJIKI, Tetsuo; 高瀬至郎; 松本逸平; UEDA, Takashi; KURODA; Yoshikazu

  日本消化器外科学会雑誌  2005/07  一般社団法人日本消化器外科学会
  
• 癌マッピングからみたss・se胆嚢癌の治療方針  [Not invited]

  AJIKI, Tetsuo; SUZUKI, Yasuyuki; FUJINO, Yasuhiro; 藤田恒憲; 松本逸平; UEDA, Takashi; 堀宏成; 美田良保; 松本拓; 富永正博; KU, Yeisei; KURODA, Yoshikazu

  日本外科学会雑誌  2005/04
• 限局した肝内胆管狭窄を呈した原発性硬化性胆管炎の2手術例  [Not invited]

  松本拓; AJIKI, Tetsuo; 藤田恒憲; 松本逸平; 美田良保; 堀宏成; UEDA, Takashi; FUJINO, Yasuhiro; SUZUKI, Yasuyuki; TOMINAGA; Masahiro, KU; Yeisei; KURODA; Yoshikazu

  日本消化器病学会雑誌  2005/03

MISC

• 慢性膵炎による難治性疼痛に対する内科的インターベンション治療と外科治療の比較解析

  松本 逸平; 三長 孝輔; 村瀬 貴昭; 宮田 剛; 川口 晃平; 亀井 敬子; 水野 修吾; 糸井 隆夫; 大原 弘隆; 正宗 淳; 阪上 順一; 佐田 尚宏; 竹中 完; 北野 雅之; 乾 和郎; 竹山 宜典  膵臓  36-  (3)  A123  -A123  2021/08
• 尾側膵切除術における新しい縫合糸を用いたバイクリルメッシュ、膵貫通マットレス法の有効性の検討 Transpancreatic mattress double suture(TPMD suture)の有効性について

  吉田 雄太; 松本 逸平; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本外科学会定期学術集会抄録集  121回-  PS  -1  2021/04
• 腹腔鏡下膵頭十二指腸切除術の安全な導入と手術手技

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本外科学会定期学術集会抄録集  121回-  PS  -8  2021/04
• 肝内胆管拡張を伴う進行肝内胆管癌に対する肝左葉切除術

  武部 敦志; 吉田 雄太; 川口 晃平; 松本 正孝; 李 東河; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 松本 逸平; 中居 卓也; 竹山 宜典  日本外科学会定期学術集会抄録集  121回-  PS  -3  2021/04
• 当院における切除可能膵癌に対する術前治療症例の検討

  李 東河; 松本 逸平; 亀井 敬子; 川口 晃平; 吉田 雄太; 松本 正孝; 村瀬 貴昭; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本外科学会定期学術集会抄録集  121回-  PS  -8  2021/04
• 慢性膵炎を巡る諸問題:早期慢性膵炎から外科治療まで 局所合併症を伴う慢性膵炎に対するFrey手術の安全性と有効性

  松本 逸平; 亀井 敬子; 竹山 宜典  日本消化器病学会雑誌  118-  (臨増総会)  A124  -A124  2021/03
• 膵癌診療ガイドライン2022の改訂作業の概況(外科療法/補助療法)

  池永直樹; 井岡達也; 江口英利; 大塚隆生; 尾上俊介; 川井学; 庄雅之; 杉浦禎一; 仲田興平; 中村聡明; 藤井努; 松本逸平; 松山隆生; 水間正道; 山本智久; 中村雅史  膵臓(Web)  36-  (3)  2021
• 慢性膵炎による難治性疼痛に対する内科的インターベンション治療と外科治療の比較解析

  松本逸平; 三長孝輔; 村瀬貴昭; 宮田剛; 川口晃平; 亀井敬子; 水野修吾; 糸井隆夫; 大原弘隆; 正宗淳; 阪上順一; 佐田尚宏; 竹中完; 北野雅之; 乾和郎; 竹山宜典  膵臓(Web)  36-  (3)  2021
• 当院における局所進行切除不能膵癌に対するconversion surgeryの短期・長期成績の検討

  吉田雄太; 松本逸平; 川口晃平; 松本正孝; 李東河; 村瀬貴昭; 亀井敬子; 里井俊平; 武部敦志; 中居卓也; 鎌田研; 山雄健太郎; 竹中完; 竹山宜典  膵臓(Web)  36-  (3)  2021
• 膵体尾部切除後膵液瘻低減を可能としたバイクリルメッシュと新規マットレス縫合糸による新しい膵断端処理法

  亀井 敬子; 松本 逸平; 吉田 雄太; 川口 晃平; 村瀬 貴昭; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本消化器外科学会総会  75回-  P300  -3  2020/12
• 膵臓 悪性

  亀井 敬子; 松本 逸平; 川口 晃平; 吉田 雄太; 村瀬 貴昭; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本消化器外科学会雑誌  53-  (Suppl.2)  317  -317  2020/11
• 膵臓 悪性

  松本 逸平; 吉田 雄太; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本消化器外科学会雑誌  53-  (Suppl.2)  319  -319  2020/11
• 膵臓 良性

  村瀬 貴昭; 松本 逸平; 吉田 雄太; 川口 晃平; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 筑後 孝章; 竹山 宜典  日本消化器外科学会雑誌  53-  (Suppl.2)  324  -324  2020/11
• 胆管癌切除後の異時性胆管癌に対する2切除例の報告

  村瀬 貴昭; 武部 敦志; 吉田 雄太; 川口 晃平; 松本 正孝; 李 東河; 亀井 敬子; 里井 俊平; 松本 逸平; 中居 卓也; 木村 雅友; 竹山 宜典  日本臨床外科学会雑誌  81-  (増刊)  543  -543  2020/10
• 膵全摘術の現状と展望 膵全摘患者のQOL調査 多施設共同前向き研究結果

  亀井 敬子; 松本 逸平; 加藤 宏之; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典  膵臓  35-  (3)  A115  -A115  2020/07
• 膵全摘術の現状と展望 膵全摘後の脂肪肝発生頻度とそのリスク解析 膵全摘患者に対する前向き実態調査の結果から

  加藤 宏之; 亀井 敬子; 須藤 広誠; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典  膵臓  35-  (3)  A117  -A117  2020/07
• 膵全摘術の現状と展望 膵全摘術後の糖尿病コントロールと栄養指標の変化について

  須藤 広誠; 亀井 敬子; 加藤 宏之; 三澤 健之; 海野 倫明; 新田 浩幸; 里井 壯平; 川畑 康成; 大塚 将之; 力山 敏樹; 首藤 毅; 松本 逸平; 岡野 圭一; 鈴木 康之; 佐田 尚宏; 伊佐地 秀司; 杉山 政則; 竹山 宜典  膵臓  35-  (3)  A118  -A118  2020/07
• 膵癌のconversion surgery:課題と展望 初診時切除不能膵癌に対する非手術療法奏効後切除の前向き観察研究 Prep-04

  元井 冬彦; 中森 正二; 松本 逸平; 里井 壯平; 平野 聡; 川畑 康成; 庄 雅之; 本田 五郎; 木村 康利; 岸和田 昌之; 青笹 季文; 岡野 圭一; 北川 裕久; 村上 義昭; 海野 倫明  膵臓  35-  (3)  A240  -A240  2020/07
• Randomized phase II trial of chemoradiotherapy with S-1 versus combination chemotherapy with gemcitabine and S-1 as neoadjuvant treatment for resectable pancreatic cancer (JASPAC 04)

  Hirochika Toyama; Teiichi Sugiura; Akira Fukutomi; Hirofumi Asakura; Yuriko Takeda; Kouji Yamamoto; Satoshi Hirano; Sohei Satoi; Ippei Matsumoto; Shinichiro Takahashi; Soichiro Morinaga; Makoto Yoshida; Yasunaru Sakuma; Hidetaka Iwamoto; Yasuhiro Shimizu; Katsuhiko Uesaka  JOURNAL OF CLINICAL ONCOLOGY  38-  (4)  2020/02
• 膵全摘術後の栄養障害とその対策

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 庭野 史丸; 廣峰 義久; 馬場谷 成; 中居 卓也; 池上 博司; 竹山 宜典  外科と代謝・栄養  54-  (5)  126  -126  2020
• 膵管狭窄症例におけるCT間接所見の検討-微小膵癌と良性膵管狭窄症例の比較-

  山雄健太郎; 竹中完; 松本逸平; 竹山宜典; 沼本勲男; 鶴崎正勝; 工藤正俊  膵臓(Web)  35-  (3)  2020
• Walled-off necrosisに対するLAMS with10FrENCD持続洗浄治療の有用性について

  竹中完; 石川嶺; 岡本彩那; 中井敦史; 山崎友裕; 大本俊介; 三長孝輔; 鎌田研; 山雄健太郎; 松本逸平; 竹山宜典; 工藤正俊  膵臓(Web)  35-  (3)  2020
• Disconnected pancreatic duct syndromeの外科治療症例の検討

  松本正孝; 松本逸平; 吉田雄太; 山雄健太郎; 川口晃平; 村瀬貴昭; 大本俊介; 亀井敬子; 里井俊平; 竹中完; 武部敦志; 中居卓也; 竹山宜典  膵臓(Web)  35-  (3)  2020
• 急性膵炎におけるプレサルコペニアの臨床的意義に関しての検討

  田中隆光; 竹中完; 吉田晃弘; 田中秀和; 吉川智恵; 石川嶺; 岡本彩那; 山崎友裕; 中井敦史; 大本俊輔; 三長孝輔; 鎌田研; 山雄健太郎; 松本逸平; 竹山宜典; 工藤正俊  日本消化器病学会雑誌(Web)  117-  2020
• バイクリルメッシュと貫通マットレス縫合による新しい尾側膵切除後膵断端処理法の有用性

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本消化器外科学会雑誌  52-  (Suppl.2)  130  -130  2019/11
• 【膵癌における内視鏡診断・治療の最前線】術後膵液瘻に対する内視鏡的ドレナージの現状

  竹中 完; 中井 敦史; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 大本 俊輔; 三長 孝輔; 鎌田 研; 山雄 健太郎; 亀井 敬子; 松本 逸平; 竹山 宜典; 工藤 正俊  胆と膵  40-  (9)  807  -814  2019/09
• 【膵癌における内視鏡診断・治療の最前線】術後膵液瘻に対する内視鏡的ドレナージの現状

  竹中 完; 中井 敦史; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 大本 俊輔; 三長 孝輔; 鎌田 研; 山雄 健太郎; 亀井 敬子; 松本 逸平; 竹山 宜典; 工藤 正俊  胆と膵  40-  (9)  807  -814  2019/09
• 南大阪地域における急性膵炎地域連携モデル構築への取り組み

  竹中完; 大本俊介; 吉川智恵; 石川嶺; 岡本彩那; 山崎友裕; 中井敦史; 三長孝輔; 鎌田研; 山雄健太郎; 松本逸平; 竹山宜典; 工藤正俊  膵臓(Web)  34-  (3)  A30‐A31(J‐STAGE)  2019/06
• 微小膵癌診断の新たなアプローチ法―3D CTによる膵実質萎縮評価から見えてきたもの―

  山雄健太郎; 竹中完; 吉川智恵; 石川嶺; 岡本彩那; 中井敦; 山崎友宏; 大本俊介; 鎌田研; 三長孝輔; 松本逸平; 竹山宜典; 鶴崎正勝; 渡邉智裕; 工藤正俊  膵臓(Web)  34-  (3)  A33‐A34(J‐STAGE)  2019/06
• 重症膵炎症例におけるプレサルコペニアと予後の関連性についての検討

  竹中完; 大本俊介; 竹山宜典; 吉川智恵; 石川嶺; 岡本彩那; 山崎友裕; 中井敦史; 三長孝輔; 鎌田研; 山雄健太郎; 松本逸平; 工藤正俊  膵臓(Web)  34-  (3)  A101‐A102(J‐STAGE)  2019/06
• 急性膵炎:診断と治療の最前線 南大阪地域における急性膵炎地域連携モデル構築への取り組み

  竹内 完; 大本 俊介; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 中井 敦史; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊  膵臓  34-  (3)  A30  -A31  2019/06
• 膵癌早期診断の最前線 微小膵癌診断の新たなアプローチ法 3D CTによる膵実質萎縮評価から見えてきたもの

  山雄 健太郎; 竹中 完; 吉川 智恵; 石川 嶺; 岡本 彩那; 中井 敦; 山崎 友宏; 大本 俊介; 鎌田 研; 三長 孝輔; 松本 逸平; 竹山 宜典; 鶴崎 正勝; 渡邉 智裕; 工藤 正俊  膵臓  34-  (3)  A33  -A34  2019/06
• 急性膵炎の重症度分類を再考する 重症膵炎症例におけるプレサルコペニアと予後の関連性についての検討

  竹中 完; 大本 俊介; 竹山 宜典; 吉川 智恵; 石川 嶺; 岡本 彩那; 山崎 友裕; 中井 敦史; 三長 孝輔; 鎌田 研; 山雄 健太郎; 松本 逸平; 工藤 正俊  膵臓  34-  (3)  A101  -A102  2019/06
• 術前診断に難渋した膵頭部・尾部同時性多発癌の一例

  岡本 彩那; 三長 孝輔; 竹中 完; 吉川 智恵; 石川 嶺; 山崎 友裕; 中井 敦史; 大本 俊介; 鎌田 研; 山雄 健太郎; 松本 逸平; 大谷 知之; 工藤 正俊  日本消化器病学会雑誌  116-  (臨増総会)  A406  -A406  2019/03
• 術前診断に難渋した膵頭部・尾部同時性多発癌の一例

  岡本 彩那; 三長 孝輔; 竹中 完; 吉川 智恵; 石川 嶺; 山崎 友裕; 中井 敦史; 大本 俊介; 鎌田 研; 山雄 健太郎; 松本 逸平; 大谷 知之; 工藤 正俊  日本消化器病学会雑誌  116-  (臨増総会)  A406  -A406  2019/03
• 膨張性発育により胆嚢から総胆管内にまで連続性充満をぎたした胆管腺扁平上皮癌の一例

  大本俊介; 竹中完; 山雄健太郎; 山崎友裕; 前西修; 筑後孝章; 柳生行伸; 鶴崎正勝; 松本逸平; 竹山宜典; 工藤正俊  日本消化器画像診断研究会プログラム・抄録集  70th-  2019
• 3D CTによる膵実質萎縮の評価が進展範囲診断に有用であった8mm膵癌の1例

  山雄健太郎; 三長孝輔; 竹中完; 樫田博史; 松本逸平; 竹山宜典; 鶴崎正勝; 前西修; 筑後孝章; 工藤正俊  日本消化器画像診断研究会プログラム・抄録集  71st-  2019
• Background and summary of the clinical diagnostic criteria for chronic pancreatitis 2019

  正宗淳; 入澤篤志; 菊田和宏; 池浦司; 伊佐地秀司; 石黒洋; 糸井隆夫; 伊藤鉄英; 乾和郎; 大原弘隆; 片岡慶正; 神澤輝実; 岸和田昌之; 北野雅之; 阪上順一; 佐田尚宏; 清水京子; 竹中完; 竹山宜典; 能登原憲司; 廣岡芳樹; 松本逸平; 宮川宏之; 岡崎和一  膵臓(Web)  34-  (6)  2019
• 術前診断に難渋した膵頭部・尾部同時性多発癌の一例

  岡本彩那; 三長孝輔; 竹中完; 吉川智恵; 石川嶺; 山崎友裕; 中井敦史; 大本俊介; 鎌田研; 山雄健太郎; 松本逸平; 大谷知之; 工藤正俊  日本消化器病学会雑誌(Web)  116-  2019
• 膵全摘術の治療成績

  松本 逸平; 吉田 雄太; 川口 晃平; 松本 正孝; 村瀬 貴昭; 岩崎 寿光; 亀井 敬子; 里井 俊平; 武部 敦志; 中居 卓也; 竹山 宜典  日本消化器外科学会雑誌  51-  (Suppl.2)  376  -376  2018/11
• A case of gallbladder carcinoma with interesting contrast-enhanced harmonic EUS image

  吉川智恵; 鎌田研; 竹中完; 大本俊介; 三長孝輔; 山雄健太郎; 今井元; 榎木英介; 木村雅友; 松本逸平; 竹山宜典; 工藤正俊  胆道  32-  (4)  775‐781  -781  2018/10
• A case of gallbladder carcinoma with interesting contrast-enhanced harmonic EUS image

  吉川智恵; 鎌田研; 竹中完; 大本俊介; 三長孝輔; 山雄健太郎; 今井元; 榎木英介; 木村雅友; 松本逸平; 竹山宜典; 工藤正俊  胆道  32-  (4)  775‐781  -781  2018/10
• 膵癌の門脈浸潤診断における造影ハーモニックEUSと造影CTの診断能の比較検討

  中井 敦史; 鎌田 研; 竹中 完; 石川 嶺; 岡本 彩那; 大本 俊介; 三長 孝輔; 山雄 健太郎; 兵頭 朋子; 松本 逸平; 竹山 宜典; 工藤 正俊  Gastroenterological Endoscopy  60-  (Suppl.2)  2126  -2126  2018/10
• 胆道・膵疾患術後の晩期障害 膵全摘術後栄養障害とQOL

  松本逸平; 吉田雄太; 川口晃平; 松本正孝; 村瀬貴昭; 亀井敬子; 里井俊平; 中居卓也; 庭野史丸; 廣峰義久; 竹山宜典  胆と膵  39-  (5)  475‐479  2018/05
• 術後膵液瘻(POPF)に対するEUS下ドレナージの有用性

  中井 敦史; 竹中 完; 山雄 健太郎; 松本 逸平; 竹山 宜典; 工藤 正俊  膵臓  33-  (3)  399  -399  2018/05
• 重症急性膵炎の予後不良予測因子および被包化壊死(WON)合併予測因子の検討

  大本 俊介; 竹中 完; 松本 逸平; 竹山 宜典; 工藤 正俊  膵臓  33-  (3)  410  -410  2018/05
• 膵頭十二指腸切除術における周術期管理標準化は術後合併症に影響を与えるか? 日本膵切研究会アンケート調査結果報告

  里井 壯平; 山本 智久; 吉富 秀幸; 元井 冬彦; 廣野 誠子; 藤井 努; 和田 慶太; 有光 秀仁; 庄 雅之; 松本 逸平; 平野 聡; 柳本 泰明; 大塚 将之; 海野 倫明; 山上 裕機; 權 雅憲  日本外科学会定期学術集会抄録集  118回-  1285  -1285  2018/04
• 膵体部の膵神経内分泌腫瘍に合併した膵性胸水の一例

  河野 辰哉; 山雄 健太郎; 中井 敦史; 大本 俊介; 鎌田 研; 三長 孝輔; 宮田 剛; 今井 元; 松本 逸平; 竹山 宜典; 田中 伴典; 筑後 孝章; 林 暁洋; 工藤 正俊  日本消化器病学会雑誌  115-  (臨増総会)  A395  -A395  2018/04
• 膵・胆管合流異常に合併した共通管内乳頭状腫瘍の1例

  幕谷 悠介; 松本 逸平; 大本 俊介; 筑後 孝章; 川口 晃平; 松本 正孝; 村瀬 貴昭; 亀井 敬子; 里井 俊平; 中居 卓也; 竹中 完; 工藤 正俊; 竹山 宜典  日本消化器外科学会雑誌  51-  (2)  114  -121  2018/02
• Papillary Neoplasm in a Common Channel in Patients with Pancreaticobiliary Maljunction

  幕谷悠介; 松本逸平; 大本俊介; 筑後孝章; 川口晃平; 松本正孝; 村瀬貴昭; 亀井敬子; 里井俊平; 中居卓也; 竹中完; 工藤正俊; 竹山宜典  日本消化器外科学会雑誌(Web)  51-  (2)  2018
• 膵癌の門脈浸潤診断における造影ハーモニックEUSと造影CTの診断能の比較検討

  中井敦史; 鎌田研; 竹中完; 石川嶺; 岡本彩那; 大本俊介; 三長孝輔; 山雄健太郎; 兵頭朋子; 松本逸平; 竹山宜典; 工藤正俊  Gastroenterological Endoscopy (Web)  60-  (Supplement2)  2018
• 膵管内に発育した5mmの退形性膵癌の1例

  中井敦史; 山雄健太郎; 竹中完; 松本逸平; 竹山宜典; 鶴崎正勝; 柳生行伸; 筑後孝章; 工藤正俊  日本消化器画像診断研究会プログラム・抄録集  69th-  55  2018
• 術前にIPMN併存癌と診断したlow‐grade PanINの1例

  山雄健太郎; 竹中完; 松本逸平; 竹山宜典; 筑後孝章; 工藤正俊  日本消化器画像診断研究会プログラム・抄録集  68th-  21  2018/01
• S-1単独療法が奏効し組織学的完全奏効が得られた切除不能膵癌の1例

  亀井 敬子; 松本 逸平; 幕谷 悠介; 川口 晃平; 松本 正孝; 村瀬 貴昭; 里井 俊平; 中居 卓也; 鎌田 研; 今井 元; 筑後 孝章; 竹山 宜典  癌と化学療法  44-  (12)  1191  -1193  2017/11
• 「それぞれの癌」難治性癌に対する治療戦略 肝・胆・膵 局所進行切除不能膵癌に対するFOLFIRINOX療法の治療成績と治療前予後因子の検討

  松本 逸平; 亀井 敬子; 大前 勝弘; 鈴木 修平; 松岡 英彦; 水野 伸匡; 尾阪 将人; 上野 秀樹; 小林 智; 上杉 和寛; 細川 貴史; 逸見 利幸; 小林 真里奈; 戸高 明子; 福冨 晃  日本癌治療学会学術集会抄録集  55回-  WS11  -6  2017/10
• 膵・胆道癌の早期診断を目指せ!実質内発生の小膵癌 IPMNに併存した小膵癌の解析

  山雄健太郎; 竹中完; 中井敦史; 大本俊介; 鎌田研; 三長孝輔; 宮田剛; 今井元; 松本逸平; 竹山宜典; 筑後孝章; 工藤正俊  肝胆膵  75-  (3)  611‐619  2017/09
• Insulin dependency with and without glucagon: marked difference in insulin requirement between patients with total pancreatectomy and type 1 diabetes

  Y. Hiromine; S. Noso; N. Babaya; H. Ito; F. Niwano; I. Matsumoto; Y. Takeyama; Y. Kawabata; H. Ikegami  DIABETOLOGIA  60-  S318  -S319  2017/09
• 【膵・胆道癌の早期診断を目指せ!】 実質内発生の小膵癌 IPMNに併存した小膵癌の解析

  山雄 健太郎; 竹中 完; 中井 敦史; 大本 俊介; 鎌田 研; 三長 孝輔; 宮田 剛; 今井 元; 松本 逸平; 竹山 宜典; 筑後 孝章; 工藤 正俊  肝・胆・膵  75-  (3)  611  -619  2017/09
• 【膵癌治療の最前線-諸問題の解決にむけた取り組み-】 高齢者膵癌に対する手術適応についての多施設共同研究

  庄 雅之; 長井 美奈子; 村上 義昭; 川井 学; 元井 冬彦; 里井 壮平; 松本 逸平; 本田 五郎; 赤堀 宇広; 中川 顕一; 中村 広太; 海野 倫明; 山上 裕機  胆と膵  38-  (8)  781  -788  2017/08
• SHORT- AND LONG-TERM RESULTS OF SURGICAL TREATMENT FOR CHRONIC PANCREATITIS: A SINGLE-CENTER RETROSPECTIVE EXPERIENCE IN JAPAN

  Ippei Matsumoto; Takaaki Murase; Keiko Kamei; Kohei Kawaguchi; Masataka Matsumoto; Shumpei Satoi; Takuya Nakai; Yoshifumi Takeyama  GASTROENTEROLOGY  152-  (5)  S1270  -S1270  2017/04
• 硬化性胆管炎と診断された膵癌、閉塞性黄疸の1例

  中井 敦史; 山雄 健太郎; 大本 俊介; 鎌田 研; 三長 孝輔; 宮田 剛; 今井 元; 竹中 完; 松本 逸平; 竹山 宜典; 筑後 孝章; 工藤 正俊  Gastroenterological Endoscopy  59-  (Suppl.1)  1061  -1061  2017/04
• 膵癌集学的治療の進歩と今後の展望

  松本 逸平; 上野 秀樹; 福冨 晃; 藤井 努; 元井 冬彦  日本消化器病学会雑誌  114-  (4)  644  -666  2017/04
• 膵の救急疾患(外傷含む) 重症急性膵炎局所合併症に対する治療の全国実態調査

  小泉 大; 佐田 尚宏; 黒河内 顕; 笹沼 英紀; 伊佐地 秀司; 糸井 隆夫; 北野 雅之; 廣田 衛久; 松本 逸平; 安田 一朗; 竹山 宜典  日本腹部救急医学会雑誌  37-  (2)  237  -237  2017/02
• 術前に肝原発嚢胞性病変が疑われた腸間膜由来神経鞘腫の1例

  竹中完; 山雄健太郎; 鎌田研; 三長孝輔; 宮田剛; 今井元; 松本逸平; 竹山宜典; 前西修; 工藤正俊  日本消化器画像診断研究会プログラム・抄録集  67th-  2017
• 膵頭部嚢胞による閉塞性黄疸症例

  大本俊介; 竹中完; 山雄健太郎; 半田康平; 筑後孝章; 松本逸平; 竹山宜典; 工藤正俊  日本消化器病学会雑誌  114-  (10)  2017
• 硬化性胆管炎と診断された膵癌,閉塞性黄疸の1例

  中井敦史; 山雄健太郎; 大本俊介; 鎌田研; 三長孝輔; 宮田剛; 今井元; 竹中完; 松本逸平; 竹山宜典; 筑後孝章; 工藤正俊  Gastroenterological Endoscopy (Web)  59-  (Supplement1)  2017
• Successful surgical treatment for intractable pancreatic ascites in patients with poor general condition: Report of 3 cases

  Keiko Kamei; Ippei Matsumoto; Kohei Kawaguchi; Masataka Matsumoto; Takaaki Murase; Shumpei Satoi; Takuya Nakai; Yoshifumi Takeyama  Japanese Journal of Gastroenterological Surgery  50-  (9)  713  -720  2017
• Nationwide survey of the treatment of local complications of severe acute pancreatitis in Japan

  KOIZUMI Masaru; SATA Naohiro; KUROGOCHI Akira; SASANUMA Hideki; ISAJI Shuji; ITOI Takao; KITANO Masayuki; HIROTA Morihisa; MATSUMOTO Ippei; YASUDA Ichiro; TAKEYAMA Yoshifumi  すい臓  31-  (3)  371‐372  2016/07
• Treatment of Local Complication of Severe Acute Pancreatitis Nationwide survey of the treatment of local complications of severe acute pancreatitis in Japan(和訳中)

  Koizumi Masaru; Sata Naohiro; Kurogochi Akira; Sasanuma Hideki; Isaji Shuji; Itoi Takao; Kitano Masayuki; Hirota Morihisa; Matsumoto Ippei; Yasuda Ichiro; Takeyama Yoshifumi  膵臓  31-  (3)  371  -372  2016/07
• 尾側膵切除後の膵内分泌機能の評価

  松本 逸平; 亀井 敬子; 松本 正孝; 村瀬 貴昭; 中多 靖幸; 里井 俊平; 石川 原; 廣峰 義久; 庭野 史丸; 川畑 由美子; 中居 卓也; 池上 博司; 竹山 宜典  胆膵の病態生理  32-  (1)  39  -42  2016/06
• 【診療ガイドライン改訂後の膵炎診療】 急性膵炎 急性膵炎診療における地域連携モデルの構築

  大本 俊介; 北野 雅之; 工藤 正俊; 松本 逸平; 竹山 宜典  肝・胆・膵  72-  (6)  1003  -1007  2016/06
• 超音波内視鏡下穿刺吸引法が術前診断,術式選択に有用であった腹腔鏡下尾側膵切除術を施行した膵solid-pseudopapillary neoplasmの1例

  亀井 敬子; 松本 逸平; 村瀬 貴昭; 石川 原; 中居 卓也; 竹山 宜典  日本内視鏡外科学会雑誌  21-  (3)  307  -313  2016/05
• 分担研究報告書「膵性糖尿病の実態調査と治療指針の作成：膵切除後糖尿病の病態と治療」

  池上博司; 川畑由美子; 廣峰義久; 伊藤鉄英; 亀井敬子; 松本逸平; 竹山宜典  厚生労働科学研究費補助金 難治性疾患等政策研究事業（難治性疾患政策研究事業）「難治性膵疾患に関する調査研究」平成27年度 総括・分担研究報告書  140  -142  2016/03
• 膵炎を繰り返すSCNとして切除を行った多房性膵嚢胞性病変の1例

  山雄健太郎; 竹中完; 大本俊介; 松田友彦; 宮田剛; 北野雅之; 工藤正俊; 松本逸平; 竹山宜典; 榎木英介; 筑後孝章  日本消化器画像診断研究会プログラム・抄録集  65th-  2016
• 胃・結腸・小腸浸潤を伴った浸潤性膵管内乳頭粘液性腺癌(IPMC)に対する1手術例

  後藤 直大; 外山 博近; 浅利 貞毅; 寺井 祥雄; 木下 秘我; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成  癌と化学療法  42-  (12)  2391  -2393  2015/11
• 膵液瘻低減を目指したバイクリルメッシュとマットレス縫合を用いた新しい尾側膵切除後膵断端処理法(第1報)

  松本 逸平; 村瀬 貴昭; 亀井 敬子; 中多 靖幸; 里井 俊平; 石川 原; 中居 卓也; 竹山 宜典  日本消化器外科学会雑誌  48-  (Suppl.2)  239  -239  2015/10
• 準緊急手術を行った難治性膵性腹水の3例

  亀井 敬子; 松本 逸平; 村瀬 貴昭; 中多 靖幸; 里井 俊平; 石川 原; 中居 卓也; 竹山 宜典  日本消化器外科学会雑誌  48-  (Suppl.2)  273  -273  2015/10
• 内視鏡外科手術の現状と将来(肝、胆、膵) 膵内視鏡外科の現状と将来 腹腔鏡下尾側膵切除術における当科の経験

  後藤 直大; 外山 博近; 浅利 貞毅; 寺井 祥雄; 石田 潤; 木下 秘我; 蔵満 薫; 松本 拓; 田中 基文; 武部 敦志; 木戸 正浩; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成  日本臨床外科学会雑誌  76-  (増刊)  417  -417  2015/10
• A case of epidermoid cyst in an intrapancreatic accessory spleen showing cyst-in-cyst-like structure mimicking mucinous cystic neoplasm

  Yuichi Hirata; Yoshifumi Arisaka; Hiromu Kutsumi; Arata Sakai; Mamoru Takenaka; Hideyuki Shiomi; Takeshi Azuma; Ippei Matsumoto; Shigeo Hara; Shujiro Yazumi  Journal of Japanese Society of Gastroenterology  112-  (10)  1858  -1867  2015/10
• 膵臓 局所進行膵がんの手術療法 膵癌術前療法後のCA19-9値<30U/mlへの低下は良好な予後を反映する

  青木 修一; 元井 冬彦; 水間 正道; 村上 義昭; 庄 雅之; 里井 壮平; 本田 五郎; 川井 学; 松本 逸平; 海野 倫明  日本癌治療学会誌  50-  (3)  1146  -1146  2015/09
• 肝細胞癌肝外転移巣に対し集学的治療を行い長期生存した1例

  権 英寿; 木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 福島 健司; 浦出 剛史; 宗 慎一; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  癌と化学療法  42-  (9)  1111  -1114  2015/09
• 神戸大学における劇症肝炎に対する移植プログラム

  蔵満 薫; 福本 巧; 木下 秘我; 田中 基文; 武部 敦志; 木戸 正浩; 矢野 嘉彦; 三住 拓誉; 松本 拓; 後藤 直大; 浅利 貞毅; 松本 逸平; 味木 徹夫; 具 英成  移植  50-  (2-3)  286  -286  2015/08
• 【1術式15分でわかる!イラスト・写真でかんたん理解!術前に予習できる消化器外科の解剖・手術はや調べファイル】 手術編 腹腔鏡下胆嚢摘出術

  亀井 敬子; 松本 逸平; 竹山 宜典  オペナーシング  30-  (8)  823  -826  2015/08
• Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus surgery-first for resectable pancreatic carcer (Prep-02/JSAP05).

  Michiaki Unno; Fuyuhiko Motoi; Tomoo Kosuge; Hideki Ueno; Hiroki Yamaue; Sohei Satoi; Masayuki Sho; Goro Honda; Ippei Matsumoto; Keita Wada; Junji Furuse; Tohru Furukawa; Kazuyuki Ishida; Kei Takase; Yutaka Matsuyama; Kei Nakagawa; Yu Katayose  JOURNAL OF CLINICAL ONCOLOGY  33-  (15)  2015/05
• Serum Carbohydrate Antigen 19-9 Values After Neoadjuvant Therapy Predict Survival of Patients With Pancreatic Adenocarcinoma: A Multicenter Case-Control Study of 269 Patients

  Shuichi Aoki; Fuyuhiko Motoi; Yoshiaki Murakami; Masayuki Sho; Sohei Satoi; Goro Honda; Hiroki Yamaue; Ippei Matsumoto; Michiaki Unno  GASTROENTEROLOGY  148-  (4)  S1162  -S1163  2015/04
• 分担研究報告書 「膵性糖尿病の実態調査と治療指針の作成：膵切除後糖尿病の病態と治療」

  池上博司; 伊藤鉄英; 廣峰義久; 川畑由美子; 亀井敬子; 松本逸平; 竹山宜典  厚生労働科学研究費補助金 難治性疾患等政策研究事業（難治性疾患政策研究事業） 「難治性膵疾患に関する調査研究」 平成26年度総括・分担研究報告書  102  -103  2015/03
• The oncologic impact of pancreatic fistula after pancreatectomy in patients with pancreatic cancer

  Manabu Kawai; Yoshiaki Murakami; Seiko Hirono; Ken-Ichi Okada; Fuyuhiko Motoi; Michiaki Unno; Masayuki Sho; Yoshiyuki Nakajima; Kenichiro Uemura; Sohei Satoi; A-Hon Kwon; Ippei Matsumoto; Sadaki Asari; Goro Honda; Masanao Kurata; Hiroki Yamaue  JOURNAL OF CLINICAL ONCOLOGY  33-  (3)  2015/01
• 【膵悪性腫瘍に対する手術;エビデンス、術式と適応、手術手技のエッセンス】重症急性膵炎合併・随伴性膵炎既往症例に対する膵頭十二指腸切除術

  後藤 直大; 外山 博近; 浅利 貞毅; 木下 秘我; 蔵満 薫; 松本 拓; 田中 基文; 武部 敦志; 木戸 正浩; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成  消化器外科  38-  (1)  45  -55  2015/01
• 肝内胆管癌再発例に対する再切除の可能性

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 後藤 直大; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  癌と化学療法  41-  (12)  1468  -1470  2014/11
• 硬化性胆管炎合併胆管癌に化学療法を行い長期生存した1例

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 吉田 優子; 村上 冴; 松本 拓; 新関 亮; 松本 逸平; 福本 巧; 具 英成  癌と化学療法  41-  (12)  1542  -1544  2014/11
• 粒子線治療後に局所再発した転移性肝癌の1切除例

  吉田 俊彦; 武部 敦志; 福本 巧; 木戸 正浩; 田中 基文; 蔵満 薫; 木下 秘我; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 後藤 直大; 松本 拓; 具 英成  癌と化学療法  41-  (12)  2071  -2073  2014/11
• 同時性腸骨転移を伴う肝細胞癌に対し集学的治療を行い長期生存を得た1例

  宗 慎一; 木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 津川 大介; 福島 健司; 浦出 剛史; 吉田 俊彦; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  癌と化学療法  41-  (12)  2107  -2109  2014/11
• S-1が著効しR0切除し得た局所進行切除不能膵癌の1例

  植田 亜津紗; 外山 博近; 後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 石田 潤; 南野 佳英; 津川 大介; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 奥野 達哉; 国分 麻佑; 伊藤 智雄; 具 英成  癌と化学療法  41-  (12)  2178  -2180  2014/11
• 膵癌術後左側門脈圧亢進症に対しHassab手術が有効であった1例

  後藤 直大; 松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 植田 亜津紗; 石田 潤; 南野 佳英; 宗 慎一; 木下 秘我; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  癌と化学療法  41-  (12)  2214  -2216  2014/11
• 膵頭十二指腸切除術後在院期間の検討

  後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 南野 佳英; 石田 潤; 木下 秘我; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本臨床外科学会雑誌  75-  (増刊)  394  -394  2014/10
• 抗リン脂質抗体症候群に合併した膵MCNの1手術症例

  多田羅 敬; 後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 木下 秘我; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本臨床外科学会雑誌  75-  (増刊)  497  -497  2014/10
• 腹腔鏡下膵体尾部切除術施行後に肺血栓塞栓症を発症した一例

  栗林 真悠; 後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 植田 亜津紗; 南野 佳英; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本臨床外科学会雑誌  75-  (増刊)  849  -849  2014/10
• 腹腔鏡下尾側膵切除術 導入から術式の定型化・技術認定医取得まで

  松本 逸平; 外山 博近; 浅利 貞毅; 後藤 直大; 植田 亜津紗; 南野 佳英; 石田 潤; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本内視鏡外科学会雑誌  19-  (7)  461  -461  2014/10
• 膵内視鏡外科の安全性と効率化 腹腔鏡下尾側膵切除術における当科の経験

  後藤 直大; 松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 南野 佳英; 石田 潤; 蔵満 薫; 松本 拓; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本内視鏡外科学会雑誌  19-  (7)  595  -595  2014/10
• 切除可否の判定に審査腹腔鏡が有用であった化学療法著効後の進行胆嚢癌の一例

  松本 拓; 味木 徹夫; 村上 冴; 吉田 優子; 篠崎 健太; 蔵満 薫; 後藤 直大; 田中 基文; 武部 敦志; 浅利 貞毅; 木戸 正浩; 外山 博近; 松本 逸平; 福本 巧; 具 英成  日本内視鏡外科学会雑誌  19-  (7)  752  -752  2014/10
• 十二指腸副乳頭部神経内分泌腫瘍に対する1手術例

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 南野 佳英; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  胆道  28-  (3)  478  -478  2014/08
• 神戸大学における劇症肝炎に対する移植プログラム

  蔵満 薫; 福本 巧; 木戸 正浩; 木下 秘我; 田中 基文; 武部 敦志; 矢野 嘉彦; 三住 拓誉; 後藤 直大; 浅利 貞毅; 外山 博近; 松本 逸平; 味木 徹夫; 具 英成  日本移植学会総会プログラム抄録集  50回-  443  -443  2014/08
• 膵腎同時移植後グラフト十二指腸穿孔を生じた1例

  後藤 直大; 松本 逸平; 外山 博近; 浅利 貞毅; 植田 亜津紗; 南野 佳英; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本移植学会総会プログラム抄録集  50回-  459  -459  2014/08
• 大腸癌肝転移に対する肝切除後の予後因子の検討

  木下 秘我; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本消化器外科学会総会  69回-  P  -4  2014/07
• 進行肝細胞癌に対するPIHPを軸とした集学的治療

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本消化器外科学会総会  69回-  RS  -1  2014/07
• 肝細胞癌治療における外科手術の位置づけ 腫瘍数4個以上の進行多発肝細胞癌に対する肝切除術の意義

  武部 敦志; 木戸 正浩; 田中 基文; 蔵満 薫; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会  69回-  WS  -6  2014/07
• 安全な肝切除術を目指して 巨大肝癌に対する肝切除のknack & pitfall

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 蔵満 薫; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 具 英成  日本消化器外科学会総会  69回-  VSY  -7  2014/07
• 体内空間可変粒子線治療による肝胆膵癌の治療

  福本 巧; 木戸 正浩; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 出水 祐介; 不和 信和; 佐々木 良平; 具 英成  日本消化器外科学会総会  69回-  O  -71  2014/07
• 膵癌術前補助療法後のCA19-9値正常化が予後に与える影響

  青木 修一; 元井 冬彦; 川井 学; 庄 雅之; 上村 健一郎; 里井 壯平; 松本 逸平; 倉田 昌直; 村上 義昭; 海野 倫明; 胆膵外科研究グルー  日本消化器外科学会総会  69回-  P  -124  2014/07
• 後腹膜脂肪肉腫術後再発に対してスペーサー手術および陽子線照射による2段階治療が奏効した1例

  岩崎 寿光; 福本 巧; 出水 祐介; 寺嶋 千貴; 藤井 收; 小松 昇平; 松本 逸平; 味木 徹夫; 不破 信和; 具 英成  日本消化器外科学会雑誌  47-  (7)  403  -409  2014/07
• Stage 0/I膵癌切除症例の検討

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 植田 亜津紗; 味木 徹夫; 岡崎 太郎; 松本 拓; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 福本 巧; 具 英成  膵臓  29-  (3)  580  -580  2014/06
• 切離部位に着目した腹腔鏡下尾側膵切除術の要点

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 南野 佳英; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  膵臓  29-  (3)  592  -592  2014/06
• 門脈腫瘍栓(Vp3,4)に対する予後改善への取り組み Vp4門脈腫瘍栓合併肝癌に対するBack Flow Thrombectomy法と経皮的肝灌流化学療法を用いた外科的治療戦略(Surgical treatment for advanced HCC with Vp4 PVTT using Back Flow Thrombectomy and Percutaneous Isolated Hepatic Perfusion)

  福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 後藤 直大; 浅利 貞毅; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  357  -357  2014/06
• 生体肝移植ドナー肝切除手術における工夫 生体肝移植ドナー肝切除手術における術中超音波胆道造影法

  浦出 剛史; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 津川 大介; 福島 健司; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  373  -373  2014/06
• vp1肝細胞癌の術後再発についての検討

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 津川 大介; 福島 健司; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 後藤 直大; 浦出 剛史; 小松 昇平; 富永 正寛; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  407  -407  2014/06
• 肝細胞癌に対する初回肝切除例における胆汁漏危険因子の解析

  木下 秘我; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 津川 大介; 後藤 直大; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  417  -417  2014/06
• 肝内胆管癌切除例における切離断端陽性リスクの検討

  武部 敦志; 味木 徹夫; 吉田 俊彦; 宗 慎一; 福島 健司; 村上 冴; 木下 秘我; 蔵満 薫; 田中 基文; 浅利 貞毅; 岡崎 太郎; 新関 亮; 木戸 正治; 松本 逸平; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  431  -431  2014/06
• 膵切除における手術手技の工夫 生食滴下式バイポーラを用いた手術手技

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 南野 佳英; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  450  -450  2014/06
• 術前診断が困難であった膵頭部IPMCの1例

  南野 佳英; 後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  508  -508  2014/06
• 術前FDG-PETにおける浸潤性膵管癌原発巣SUV値と予後に関する検討

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 南野 佳英; 植田 亜津紗; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  511  -511  2014/06
• 幽門輪温存膵頭十二指腸切除術と亜全胃温存膵頭十二指腸切除術の短期・長期成績の前向き比較検討

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 植田 亜津紗; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  519  -519  2014/06
• 術前診断が困難であった膵内副脾Epidermoid cystの1例

  植田 亜津紗; 新関 亮; 松本 逸平; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 岡崎 太郎; 武部 敦志; 田中 基文; 蔵満 薫; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  528  -528  2014/06
• 膵頭部領域悪性腫瘍患者6例に発生した重症急性膵炎後の膵頭十二指腸切除術の周術期管理について(Perioperative management for pancreatoduodenectomy following severe acute pancreatitis in patients with periampullary tumor: experience with consecutive 6 cases)

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 味木 徹夫; 岡崎 太郎; 松本 拓; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  625  -625  2014/06
• 肝切除における当科の術前シミュレーションの現状

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 吉田 俊彦; 岡崎 太郎; 浅利 貞毅; 後藤 直大; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  661  -661  2014/06
• 経皮的冠動脈形成術(PCI)後症例における肝胆膵外科手術

  新関 亮; 松本 逸平; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 南野 佳英; 植田 亜津紗; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  26回-  711  -711  2014/06
• 膵癌に対する膵頭十二指腸切除術後左側門脈圧亢進症に対しHassab手術を施行した1例

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 植田 亜津紗; 南野 佳英; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徳夫; 福本 巧; 具 英成  日本癌治療学会誌  49-  (3)  2092  -2092  2014/06
• 術後CA19-9値の遷延上昇は、肝転移再発・予後不良のリスク因子である

  元井 冬彦; 村上 義昭; 川井 学; 松本 逸平; 上村 健一郎; 里井 壯平; 庄 雅之; 本田 五郎; 山上 裕機; 後藤 直大; 柳本 泰明; 木下 正一; 倉田 昌直; 青木 修一; 水間 正道; 海野 倫明; Multicenter Study; Group of Pancreatobiliary Surgery  膵臓  29-  (3)  379  -379  2014/06
• 膵癌に対する新たな治療戦略 切除可能膵癌 術前治療後のCA19-9値正常化は、切除可能膵癌の重要な予後因子である

  青木 修一; 元井 冬彦; 水間 正道; 村上 義昭; 庄 雅之; 里井 壮平; 本田 五郎; 上村 健一郎; 川井 学; 松本 逸平; 海野 倫明; 胆膵外科研究グルー  膵臓  29-  (3)  391  -391  2014/06
• 【エキスパートに学ぶ膵縮小手術】 膵中央切除(MR)

  松本 逸平; 新関 亮; 浅利 貞毅; 味木 徹夫; 福本 巧; 具 英成  手術  68-  (7)  919  -922  2014/06
• 生体肝移植後直腸癌とグラフト肝への転移を併発した1例

  木下 秘我; 福本 巧; 蔵満 薫; 木戸 正浩; 武部 敦志; 田中 基文; 小松 昇平; 松本 逸平; 味木 徹夫; 具 英成  移植  49-  (1)  112  -112  2014/05
• The Impact of Pancreatic Fistula Grade C on Survival After Pancreatic Resection; Analysis of 1,015 Patients With Pancreatic Cancer in Multicenter Study

  Manabu Kawai; Yoshiaki Murakami; Masaji Tani; Seiko Hirono; Ken-ichi Okada; Fuyuhiko Motoi; Michiaki Unno; Masayuki Sho; Yoshiyuki Nakajima; Kenichiro Uemura; Sohei Satoi; A-Hon Kwon; Ippei Matsumoto; Tadahiro Goto; Goro Honda; Masanao Kurata; Hiroki Yamaue  GASTROENTEROLOGY  146-  (5)  S1047  -S1048  2014/05
• Is Partial Resection of Portal or Superior Mesenteric Vein Justified for Patients With Pancreatic Head Carcinoma?

  Yoshiaki Murakami; Kenichiro Uemura; Sohei Satoi; Masayuki Sho; Fuyuhiko Motoi; Goro Honda; Manabu Kawai; Ippei Matsumoto; Seiko Hirono; Masanao Kurata; Hiroaki Yanagimoto; Takahiro Akahori; Makoto Shinzeki; Michiaki Unno  GASTROENTEROLOGY  146-  (5)  S1047  -S1047  2014/05
• Impact of Preoperative Biliary Drainage on Short- and Long-Term Outcome After Pancreaticoduodenectomy for Cancer of the Head of Pancreas

  Kenichiro Uemura; Yoshiaki Murakami; Manabu Kawai; Ken-ichi Okada; Ippei Matsumoto; Sadaki Asari; Sohei Satoi; Hiroaki Yanagimoto; Masayuki Sho; Takahiro Akahori; Goro Honda; Masanao Kurata; Fuyuhiko Motoi; Michiaki Unno  GASTROENTEROLOGY  146-  (5)  S1045  -S1046  2014/05
• Pancreatic Serous Cystadenoma Related Mortality Is Nil. Results of a Multinational Study Under the Auspices of the International Association of Pancreatology and the European Pancreatic Club

  Benedicte Jais; Vinciane Rebours; Myung-Hwan Kim; Yeonjung Ha; Wataru Kimura; Ichiro Hirai; Giovanni Marchegiani; Carlos Fernandez-del Castillo; Ilias P. Gomatos; John Neoptolemos; Cosimo Sperti; Anna Caterina Milanetto; Huaizhi Wang; Claudio Ricci; Riccardo Casadei; Liudmyla Pererva; Kostiantyn Kopchak; Ippei Matsumoto; Makoto Shinzeki; Marco Del Chiaro; Ralf Segersvaerd; Isis K. Araujo Acuna; Eva C. Vaquero; Maria Rachele Angiolini; Alessandro Zerbi; Mohammad Abu Hilal; Julia Burkert; Chang Geun Lee; Mehdi Ouaissi; Bernard Sastre; Maria C. Petrone; Paolo G. Arcidiacono; Philippe Levy  GASTROENTEROLOGY  146-  (5)  S137  -S138  2014/05
• Reappraisal of Peritoneal Cytology in 984 Patients With Pancreatic Cancer Who Underwent Curative Resection

  Sohei Satoi; Fuyuhiko Motoi; Kenichiro Uemura; Manabu Kawai; Masanao Kurata; Masayuki Sho; Ippei Matsumoto; Hiroaki Yanagimoto; Michiaki Unno; Hiroki Yamaue; Goro Honda; Yoshiyuki Nakajima; Makoto Shinzeki; A-Hon Kwon; Yoshiaki Murakami  GASTROENTEROLOGY  146-  (5)  S1030  -S1030  2014/05
• ERCP後重症急性膵炎後の膵頭十二指腸切除術例の検討

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  Gastroenterological Endoscopy  56-  (Suppl.1)  1150  -1150  2014/04
• Respiratory-gated F-18-FDG PET/CT for the diagnosis of liver metastasis (vol 82, pg 1696, 2013)

  Yuko Suenaga; Kazuhiro Kitajima; Hajime Aoki; Takashi Okunaga; Atsushi Kono; Ippei Matsumoto; Takumi Fukumoto; Kenichi Tanaka; Kazuro Sugimura  EUROPEAN JOURNAL OF RADIOLOGY  83-  (4)  741  -741  2014/04
• 腎癌膵転移に対して2度の縮小手術を行った1例

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 岡崎 太郎; 武部 敦志; 田中 基文; 蔵満 薫; 木戸 正浩; 味木 徹夫; 福本 巧; 原 重雄; 具 英成  膵臓  29-  (2)  247  -252  2014/04
• PLS-10-7 MDCTによる膵頭部癌の膵外神経叢浸潤に関する術前評価基準の検討(PLS-10 プレナリーセッション(10)「膵臓」,第114回日本外科学会定期学術集会)

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 石田 潤; 松本 拓; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  297  -297  2014/03
• OP-088-5 神戸大学におけるポジティブアクションプログラム(OP-088 女性外科医,一般演題,第114回日本外科学会定期学術集会)

  蔵満 薫; 福本 巧; 木戸 正浩; 木下 秘我; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  115-  (2)  471  -471  2014/03
• OP-093-5 閉塞性黄疸手術例に対する外瘻胆汁返還中の全身・腸管免疫能の動態の解析(OP-093 胆 基礎・研究,一般演題,第114回日本外科学会定期学術集会)

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 宇佐美 眞; 具 英成  日本外科学会雑誌  115-  (2)  480  -480  2014/03
• CH-2-5 地域医療循環型人材育成プログラムを用いた神戸大学と兵庫県の地域外科医療連携 : 兵庫県立柏原病院での実践(CH-2 地域医療関連セッション(2)「地域外科医療を支えるための工夫」,第114回日本外科学会定期学術集会)

  味木 徹夫; 大野 伯和; 高瀬 至郎; 中島 高広; 松本 逸平; 福本 巧; 具 具  日本外科学会雑誌  115-  (2)  270  -270  2014/03
• OP-113-1 膵神経内分泌腫瘍(PNET)の転移に関わる因子の検討(OP-113 膵 内分泌腫瘍 転移,一般演題,第114回日本外科学会定期学術集会)

  南野 佳英; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  514  -514  2014/03
• OP-110-4 膵切除術における周術期管理(OP-110 膵 周術期管理,一般演題,第114回日本外科学会定期学術集会)

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  509  -509  2014/03
• VSY-1-10 腫瘍栓合併肝静脈根部大型肝癌に対する外科治療(VSY-1 ビデオシンポジウム(1)肝静脈根部大型肝癌に対する肝切除術式の工夫,第114回日本外科学会定期学術集会)

  福本 巧; 木戸 正浩; 武部 敦; 田中 基文; 蔵満 薫; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  115-  (2)  148  -148  2014/03
• PS-027-8 術前胆道ドレナージを要した胆道癌における周術期感染症の検討(PS-027 周術期管理 SSI・感染症,ポスターセッション,第114回日本外科学会定期学術集会)

  岡崎 太郎; 味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 蔵満 薫; 田中 基文; 浅利 貞毅; 武部 敦志; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  629  -629  2014/03
• PS-092-2 良低悪性度腫瘍に対する腹腔鏡下膵体尾部切除術(PS-092 膵 手術手技-2,ポスターセッション,第114回日本外科学会定期学術集会)

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  758  -758  2014/03
• PS-092-5 膵腫瘍核出術における内視鏡下膵管ステントの適応(PS-092 膵 手術手技-2,ポスターセッション,第114回日本外科学会定期学術集会)

  新関 亮; 松本 逸平; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 後藤 直大; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  759  -759  2014/03
• PS-163-5 膵頭十二指腸切除が膵内分泌機能に及ぼす影響について(PS-163 膵 周術期管理,ポスターセッション,第114回日本外科学会定期学術集会)

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  901  -901  2014/03
• PS-156-4 末期肝硬変患者における副腎機能評価の検討(PS-156 肝 その他-3・門脈,ポスターセッション,第114回日本外科学会定期学術集会)

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  115-  (2)  886  -886  2014/03
• PS-077-4 進行多発肝細胞癌に対する外科治療の役割(PS-077 肝 肝細胞癌-1,ポスターセッション,第114回日本外科学会定期学術集会)

  武部 敦志; 福本 巧; 木戸 正浩; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健二; 浦出 剛史; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  115-  (2)  728  -728  2014/03
• PS-085-8 十二指腸乳頭部癌術後早期合併症の検討(PS-085 胆 悪性-4,ポスターセッション,第114回日本外科学会定期学術集会)

  松本 拓; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  115-  (2)  745  -745  2014/03
• 経乳頭的胆嚢胆汁細胞診の検討

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 浅利 貞毅; 後藤 直大; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 塩見 英之; 増田 充弘; 有坂 好史; 久津見 弘; 具 英成  日本消化器病学会雑誌  111-  (臨増総会)  A292  -A292  2014/03
• 肝細胞癌vp1症例術後再発形式の検討

  小松 昇平; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 福島 健司; 浦出 剛史; 宗 慎一; 松本 逸平; 味木 徹夫; 千堂 宏義; 杉本 武巳; 藤野 泰宏; 富永 正寛; 具 英成  新薬と臨牀  63-  (3)  479  -479  2014/03
• 肝静脈根部大型肝癌に対する肝切除術式の工夫 腫瘍栓合併肝静脈根部大型肝癌に対する外科治療

  福本 巧; 木戸 正浩; 武部 敦; 田中 基文; 蔵満 薫; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  115-  (臨増2)  148  -148  2014/03
• 神戸大学におけるポジティブアクションプログラム

  蔵満 薫; 福本 巧; 木戸 正浩; 木下 秘我; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  115-  (臨増2)  471  -471  2014/03
• 膵切除術における周術期管理

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (臨増2)  509  -509  2014/03
• 膵神経内分泌腫瘍(PNET)の転移に関わる因子の検討

  南野 佳英; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (臨増2)  514  -514  2014/03
• 新臨床研修制度導入後の外科医育成の取り組み

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 具 英成  日本外科学会雑誌  115-  (臨増2)  623  -623  2014/03
• 術前胆道ドレナージを要した胆道癌における周術期感染症の検討

  岡崎 太郎; 味木 徹夫; 松本 拓; 村上 冴; 吉田 優子; 篠崎 健太; 蔵満 薫; 田中 基文; 浅利 貞毅; 武部 敦志; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  115-  (臨増2)  629  -629  2014/03
• 進行多発肝細胞癌に対する外科治療の役割

  武部 敦志; 福本 巧; 木戸 正浩; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健二; 浦出 剛史; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 貝 英成  日本外科学会雑誌  115-  (臨増2)  728  -728  2014/03
• 良低悪性度腫瘍に対する腹腔鏡下膵体尾部切除術

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 松本 拓; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (臨増2)  758  -758  2014/03
• 膵腫瘍核出術における内視鏡下膵管ステントの適応

  新関 亮; 松本 逸平; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 後藤 直大; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  115-  (臨増2)  759  -759  2014/03
• 末期肝硬変患者における副腎機能評価の検討

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 津川 大介; 福島 健司; 浦出 剛史; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  115-  (臨増2)  886  -886  2014/03
• 膵癌術後補助化学療法の完遂予測因子の検討

  後藤 直大; 松本 逸平; 田中 正樹; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本消化器病学会雑誌  111-  (臨増総会)  A267  -A267  2014/03
• 肝移植後長期生着を目指して

  蔵満 薫; 福本 巧; 木戸 正浩; 木下 秘我; 田中 基文; 武部 敦志; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本消化器病学会雑誌  111-  (臨増総会)  A278  -A278  2014/03
• 膵癌との鑑別を要した自己免疫性膵炎の検討 外科医が経験した9例

  浅利 貞毅; 松本 逸平; 新関 亮; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 味木 徹夫; 岡崎 太郎; 松本 拓; 木戸 正浩; 武部 敦志; 田中 基文; 蔵満 薫; 福本 巧; 具 英成  日本消化器病学会雑誌  111-  (臨増総会)  A373  -A373  2014/03
• 【胆道癌として外科切除された鑑別困難病変の検証-画像と病理所見の対比-】 胆管癌と鑑別困難であった良性胆管狭窄の臨床病理学的特徴

  村上 冴; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 篠崎 健太; 松本 逸平; 福本 巧; 原 重雄; 具 英成  胆と膵  35-  (3)  255  -261  2014/03
• 大動脈周囲リンパ節転移を認めたDulα十二指腸乳頭部癌の1例

  岡崎 太郎; 味木 徹夫; 松本 逸平; 福本 巧; 塩見 英之; 増田 充弘; 近藤 武史; 山崎 隆; 伊藤 智雄; 具 英成  胆道  27-  (5)  811  -816  2013/12
• 腹腔鏡下尾側膵切除術におけるシリコンディスクを用いた胃・肝圧排法

  新関 亮; Matsumoto Ippei; Asari Sadaki; Goto Tadahiro; 田中 正樹; 山下 博成; 石田 潤; 田中 基文; 岡崎 太郎; Takebe Atsushi; Kito Masahiro; 味木 徹夫; 福本 巧; Ku Yonson  日本内視鏡外科学会雑誌  18-  (7号)  769  -769  2013/11
• 内視鏡外科技術認定の現況 腹腔鏡下尾側膵切除術 術式の定型化と技術認定医をめざして

  Goto Tadahiro; Matsumoto Ippei; 新関 亮; Asari Sadaki; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; Takebe Atsushi; 岡崎 太郎; Kito Masahiro; 味木 徹夫; 福本 巧; Ku Yonson  日本内視鏡外科学会雑誌  18-  (7号)  293  -293  2013/11
• 当科における腹腔鏡下肝切除の工夫

  Kito Masahiro; 福本 巧; Takebe Atsushi; 田中 基文; 木下 秘我; 小松 昇平; 福島 健司; 浦出 剛史; 味木 徹夫; Matsumoto Ippei; 新関 亮; Asari Sadaki; 蔵満 薫; Ku Yonson  日本内視鏡外科学会雑誌  18-  (7号)  442  -442  2013/11
• 胆嚢摘出時の術中胆道造影における胆汁膵管逆流現象の臨床的意義

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 村上 冴; 吉田 優子; 松本 たく; 松本 拓; 蔵満 薫; 田中 基文; Asari Sadaki; Takebe Atsushi; 新関 亮; Kito Masahiro; Matsumoto Ippei; 福本 巧; Ku Yonson  日本内視鏡外科学会雑誌  18-  (7号)  569  -569  2013/11
• 肝嚢胞に対する腹腔鏡下開窓術

  木下 秘我; Kito Masahiro; 小松 昇平; 蔵満 薫; 田中 基文; Takebe Atsushi; Asari Sadaki; 岡崎 太郎; 新関 亮; Matsumoto Ippei; 味木 徹夫; 福本 巧; Ku Yonson  日本内視鏡外科学会雑誌  18-  (7号)  660  -660  2013/11
• 抗血栓薬服用患者に対する胆嚢摘出術症例の検討

  大坪 出; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  日本腹部救急医学会雑誌  33-  (7)  1097  -1102  2013/11
• 肝外胆管原発印環細胞癌に対して胆管切除術を施行した1例

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 村上 冴; 吉田 優子; 松本 逸平; 福本 巧; 川上 史; 原 重雄; 具 英成  日本消化器外科学会雑誌  46-  (11)  840  -846  2013/11
• 進行肝細胞癌に対する粒子線治療後にPIHPを施行した症例の検討

  田中 基文; 福本 巧; 木戸 正浩; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 浦出 剛史; 宗 慎一; 新関 亮; 松本 逸平; 味木 徹夫; 寺嶋 千貴; 藤井 收; 出水 祐介; 不破 信和; 具 英成  癌と化学療法  40-  (12)  1681  -1683  2013/11
• 集学的治療により長期生存を得ている大動脈周囲リンパ節転移陽性胆管癌の1例

  山田 勇; 篠崎 健太; 味木 徹夫; 岡崎 太郎; 吉田 優子; 村上 冴; 大坪 出; 白川 幸代; 田中 正樹; 椋棒 英世; 後藤 直大; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 村上 昌雄; 具 英成  癌と化学療法  40-  (12)  1741  -1743  2013/11
• 切除不能胆嚢癌に対し化学療法施行後に切除を施行した1例

  村上 冴; 味木 徹夫; 篠崎 健太; 吉田 優子; 大坪 出; 岡崎 太郎; 後藤 直大; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  癌と化学療法  40-  (12)  1744  -1746  2013/11
• 集学的治療における術前経皮的肝灌流化学療法と肝切除の位置付け

  吉田 俊彦; 木戸 正浩; 福本 巧; 小松 昇平; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 具 英成  癌と化学療法  40-  (12)  1822  -1824  2013/11
• 初回切除後4年で発症した異時性膵癌の1例

  石田 潤; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  癌と化学療法  40-  (12)  1893  -1896  2013/11
• Graft Type Significantly Associates with the Incidence of Posthepatectomy Liver Failure Defined by ISGLS in Living Donors after Hepatectomy

  Kaori Kuramitsu; Takumi Fukumoto; Kenji Fukushima; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku  HEPATOLOGY  58-  775A  -775A  2013/10
• 進行肝癌の切除限界克服を目指した新展開 進行肝細胞癌に対する術前化学療法としてのPIHP(経皮的肝灌流)の安全性と有用性の検討

  田中 基文; 福本 巧; Kito Masahiro; Takebe Atsushi; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 浦出 剛史; 宗 慎一; 新関 亮; Matsumoto Ippei; 味木 徹夫; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  435  -435  2013/10
• Denver型腹腔静脈シャント留置後に発症したDICに対し遺伝子組換え型トロンボモジュリンが著効した一例

  權田 真知; 田中 基文; 木下 秘我; 福本 巧; Kito Masahiro; Takebe Atsushi; 蔵満 薫; 小松 昇平; 福島 健司; 浦出 剛史; 宗 慎一; 新関 亮; Matsumoto Ippei; 味木 徹夫; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  1020  -1020  2013/10
• 吻合、再建の手術手技(膵臓) 膵頭十二指腸切除術における安全、確実な膵空腸再建手術手技

  Goto Tadahiro; Matsumoto Ippei; 新関 亮; Asari Sadaki; 石田 潤; 山下 博成; 田中 正樹; 蔵満 薫; 田中 基文; Takebe Atsushi; 岡崎 太郎; Kito Masahiro; 味木 徹夫; 福本 巧; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  354  -354  2013/10
• 同時性胆道重複癌の検討

  松本 拓; 味木 徹夫; 篠崎 健太; 吉田 優子; 村上 冴; 岡崎 太郎; 田中 基文; Asari Sadaki; Takebe Atsushi; 新関 亮; Kito Masahiro; Matsumoto Ippei; 福本 巧; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  996  -996  2013/10
• 当施設における外科医リクルート戦略

  Kito Masahiro; 福本 巧; Takebe Atsushi; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 福島 健司; 浦出 剛史; 味木 徹夫; Matsumoto Ippei; 新関 亮; 岡崎 太郎; Asari Sadaki; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  317  -317  2013/10
• 臓器移植の現状と問題点 臓器移植法改正後の肝移植の現況

  Takebe Atsushi; 福本 巧; 木戸 正治; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 浦出 剛史; 福島 健司; Asari Sadaki; 岡崎 太郎; 新関 亮; Matsumoto Ippei; 味木 徹夫; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  363  -363  2013/10
• 術前胆道ドレナージ症例における術後胆管炎の検討

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 吉田 優子; 村上 冴; 松本 拓; 蔵満 薫; Takebe Atsushi; Asari Sadaki; 新関 亮; Kito Masahiro; Matsumoto Ippei; 福本 巧; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  498  -498  2013/10
• 主膵管との交通を認め術前診断が困難であった膵粘液性嚢胞腫瘍(MCN)の1切除例

  杉田 裕; Goto Tadahiro; Matsumoto Ippei; 新関 亮; Asari Sadaki; 石田 潤; 山下 博成; 田中 正樹; 田中 基文; Takebe Atsushi; 岡崎 太郎; Kito Masahiro; 味木 徹夫; 福本 巧; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  1031  -1031  2013/10
• 肝門部胆管癌におけるR0切除と術後補助化学療法の意義

  味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 吉田 優子; Matsumoto Ippei; 新関 亮; Asari Sadaki; 蔵満 薫; 田中 基文; Takebe Atsushi; Kito Masahiro; 福本 巧; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  617  -617  2013/10
• 肝内結石症長期観察中に発生した広範な肝内胆管癌の一切除例

  吉田 優子; 味木 徹夫; 岡崎 太郎; 松本 拓; 村上 冴; 篠崎 健太; 田中 基文; Takebe Atsushi; Asari Sadaki; Kito Masahiro; 新関 亮; Matsumoto Ippei; 福本 巧; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  996  -996  2013/10
• 肝切除後に肝鎌状間膜内再発を来した肝細胞癌の一例

  宗 慎一; Kito Masahiro; 福本 巧; Takebe Atsushi; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 福島 健司; 味木 徹夫; Matsumoto Ippei; 新関 亮; 岡崎 太郎; Asari Sadaki; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  865  -865  2013/10
• リンパ節転移を伴った腫瘍径14mmの非機能性膵内分泌腫瘍の1例

  南野 佳英; Matsumoto Ippei; Goto Tadahiro; 山下 博成; 田中 正樹; Asari Sadaki; 新関 亮; 蔵満 薫; 田中 基文; Takebe Atsushi; 岡崎 太郎; Kito Masahiro; 味木 徹夫; 福本 巧; Ku Yonson  日本臨床外科学会雑誌  74-  (増刊)  766  -766  2013/10
• 進行肝細胞癌に対する新しい治療戦略

  木戸 正浩; 福本 巧; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 浅利 貞毅; 具 英成  日本癌治療学会誌  48-  (3)  988  -988  2013/09
• 膵癌切除後早期再発の危険因子

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 田中 正樹; 山下 博成; 石田 潤; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本癌治療学会誌  48-  (3)  1524  -1524  2013/09
• 高濃度Cisplatinを用いた肝動注療法の実現に向けた動物モデルの構築と基礎検討

  武部 敦志; 福本 巧; 木戸 正浩; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昌平; 福島 健司; 浦出 剛史; 宗 慎一; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本癌治療学会誌  48-  (3)  1947  -1947  2013/09
• 膵癌術後補助化学療法における血清アルブミン値の重要性

  後藤 直大; 松本 逸平; 田中 正樹; 新関 亮; 浅利 貞毅; 石田 潤; 山下 博成; 蔵満 薫; 田中 基文; 武部 敦志; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本癌治療学会誌  48-  (3)  1960  -1960  2013/09
• 臓器移植法改正後の劇症肝炎に対する肝移植

  Takebe Atsushi; 福本 巧; 木戸 正浩; 木戸 正治; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 福島 健司; 宗 慎一; 新関 亮; Matsumoto Ippei; 味木 徹夫; Ku Yonson  日本消化器病学会雑誌  110-  (臨増大会)  A837  -A837  2013/09
• スペーサー手術と粒子線照射による腹部・骨盤部悪性腫瘍の治療

  福本 巧; Kito Masahiro; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 松本 逸平; 味木 徹夫; 出水 祐介; 不破 信和; Sasaki Ryohei; 具 英成  日本癌治療学会誌  48-  (3号)  1174  -1174  2013/09  [Refereed]
  
• 肝移植後長期合併症の管理

  蔵満 薫; 福本 巧; 木戸 正浩; 福島 健司; 小松 昇平; 木下 秘我; 田中 基文; 武部 敦志; 松本 逸平; 味木 徹夫; 具 英成  移植  48-  (総会臨時)  355  -355  2013/08
• Difficult Stoneに対する外科的治療戦略

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 松本 拓; 吉田 優子; 村上 冴; 大坪 出; 田中 正樹; Goto Tadahiro; Asari Sadaki; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  胆道  27-  (3号)  545  -545  2013/08  [Refereed]
  
• 新たな術前肝予備能評価法とその臨床応用 肝右葉切除の術前評価における99mTc-GSAシンチグラフィーの有用性について

  田中 基文; 木戸 正浩; 高橋 応典; 武部 敦志; 蔵満 薫; 福島 健司; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会  68回-  PD  -2  2013/07
• 次世代に向けた消化器外科におけるNavigation Surgery 細胞標識、画像応用を含めて ソナゾイド術中超音波下胆道造影を用いた肝胆道ナビゲーション手術

  浦出 剛史; 田中 基文; 福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 蔵満 薫; 松本 逸平; 味木 徹夫; 具 英成  日本消化器外科学会総会  68回-  WS  -8  2013/07
• 肝切除における合併症予防策

  木戸 正浩; 福本 巧; 高橋 応典; 武部 敦志; 田中 基文; 木下 秘我; 蔵満 薫; 味木 徹夫; 松本 逸平; 具 英成  日本消化器外科学会総会  68回-  O  -2  2013/07
• 3cm、3個以下の肝細胞癌に対する肝切除、生体肝移植の治療成績

  福島 健司; 木戸 正浩; 福本 巧; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 松本 逸平; 味木 徹夫; 具 英成  日本消化器外科学会総会  68回-  RS  -2  2013/07
• 進行・再発肝細胞癌に対する治療戦略 超進行肝癌に対するPIHPを基軸とした治療戦略 Back Flow Perfusion法と3段階治療の役割

  福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 松本 逸平; 味木 徹夫; 具 英成  日本消化器外科学会総会  68回-  SY  -7  2013/07
• 高齢者膵癌に対する治療選択と成績

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 椋棒 英世; 山下 博成; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会  68回-  P  -9  2013/07
• 胆嚢癌との鑑別が困難であった著明な粘液産生を伴う胆嚢腺筋腫症の1例

  大坪 出; 味木 徹夫; 岡崎 太郎; 松本 逸平; 福本 巧; 原 重雄; 具 英成  日本臨床外科学会雑誌  74-  (7)  1988  -1992  2013/07
• 膵頭十二指腸切除術における安全、確実な膵空腸吻合手術手技

  松本 逸平; 新関 亮; Asari Sadaki; Goto Tadahiro; 椋棒 英世; 白川 幸代; 山下 博成; 田中 正樹; 石田 潤; 岩崎 寿光; 岡崎 太郎; Takebe Atsushi; 高橋 応典; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  308  -308  2013/06  [Refereed]
  
• 肝切離術の工夫 当科での肝癌に対する肝切除の工夫

  福島 健司; 木戸 正浩; 福本 巧; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 中馬 正志; 浦出 剛史; 宋 慎一; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  25回-  216  -216  2013/06
• 肝癌診療ガイドライン2009に基づく治療成績 肝癌診療ガイドラインを越えた肝細胞癌治療の現況

  小松 昇平; 福本 巧; 木下 秘我; 蔵満 薫; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 寺嶋 千貴; 藤井 収; 出水 祐介; 不破 信和; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  25回-  250  -250  2013/06
• 非B非C肝炎肝癌の外科的治療成績 神戸大学における非B非C肝癌の外科的治療成績

  武部 敦志; 福本 巧; 木戸 正治; 田中 基文; 蔵満 薫; 福島 健司; 浦出 剛史; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  25回-  267  -267  2013/06
• 生体肝移植の手術手技の工夫 高度門脈血栓合併症例に対する門脈再建術の工夫

  蔵満 薫; 福本 巧; 木戸 正浩; 武部 敦志; 田中 基文; 木下 秘我; 小松 昇平; 松本 逸平; 味木 徹夫; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  25回-  288  -288  2013/06
• 肝細胞癌多発肺転移、リンパ節転移に対し集学的治療を行い、長期生存を得た1例

  木下 秘我; 木戸 正浩; 宗 慎一; 浦出 剛史; 福島 健司; 中馬 正志; 小松 昇平; 蔵満 薫; 田中 基文; 武部 敦志; 高橋 応典; 松本 逸平; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集  25回-  346  -346  2013/06
• 膵切離術の工夫 重症急性膵炎併発例に対する膵頭十二指腸切除術の手術手技

  Goto Tadahiro; 松本 逸平; 新関 亮; Asari Sadaki; 椋棒 英世; 石田 潤; 白川 幸代; 山下 博成; 田中 正樹; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  229  -229  2013/06  [Refereed]
  
• 膵移植血行再建術の手術手技

  Asari Sadaki; 松本 逸平; 新関 亮; Goto Tadahiro; 椋棒 英世; 白川 幸代; 田中 正樹; 山下 博成; 岩崎 寿光; 岡崎 太郎; 木戸 正浩; 高橋 応典; Takebe Atsushi; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  302  -302  2013/06  [Refereed]
  
• 膵移植の工夫

  Asari Sadaki; 松本 逸平; 新開 亮; Goto Tadahiro; 椋棒 英世; 白川 幸代; 田中 正樹; 山下 博成; 石田 潤; 岩崎 寿光; 岡崎 太郎; 蔵満 薫; Takebe Atsushi; 高橋 応典; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  302  -302  2013/06  [Refereed]
  
• 腹腔動脈幹合併膵体尾部切除術後の膵瘻による仮性動脈瘤出血に対し、TAEと開腹ドレナージにて救命した一例

  山下 博成; 松本 逸平; 新関 亮; Asari Sadaki; Goto Tadahiro; 椋棒 英世; 白川 幸代; 田中 正樹; 岩崎 寿光; 石田 潤; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  450  -450  2013/06  [Refereed]
  
• 腹腔鏡下脾臓・脾動静脈温存膵体尾部切除術の問題点

  新関 亮; 松本 逸平; 石田 潤; 岩崎 寿光; 山下 博成; 白川 幸代; 田中 正樹; Goto Tadahiro; Asari Sadaki; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  296  -296  2013/06  [Refereed]
  
• 胆道癌に対する治療戦略 大動脈周囲リンパ節陽性胆道癌の切除成績

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 大坪 出; 村上 冴; 吉田 優子; Asari Sadaki; Goto Tadahiro; 田中 正樹; 白川 幸代; 岩崎 寿光; 石田 潤; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  262  -262  2013/06  [Refereed]
  
• 自験例からみた主膵管型IPMNに対する至適術式の検討

  石田 潤; 松本 逸平; 新関 亮; Asari Sadaki; Goto Tadahiro; 椋棒 英世; 田中 正樹; 白川 幸代; 山下 博成; 岩崎 寿光; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  381  -381  2013/06  [Refereed]
  
• StageIV進行肝細胞癌に対する肝切除術 高度脈管侵襲合併肝細胞癌に対する肝切除

  木戸 正浩; 福本 巧; Takebe Atsushi; 田中 基文; 木下 秘我; 蔵満 薫; 小松 昇平; 福島 健司; 浦出 剛史; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; Asari Sadaki; 具 英成  日本肝胆膵外科学会・学術集会プログラム・抄録集25回  25回-  277  -277  2013/06  [Refereed]
  
• JASPAC 01: Randomized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 for patients with resected pancreatic cancer

  Akira Fukutomi; Katsuhiko Uesaka; Narikazu Boku; Hideyuki Kanemoto; Masaru Konishi; Ippei Matsumoto; Yuji Kaneoka; Yasuhiro Shimizu; Shoji Nakamori; Hirohiko Sakamoto; Soichiro Morinaga; Osamu Kainuma; Koji Imai; Naohiro Sata; Shoichi Hishinuma; Takayuki Nakamura; Michio Kanai; Satoshi Hirano; Yukinobu Yoshikawa; Yasuo Ohashi  JOURNAL OF CLINICAL ONCOLOGY  31-  (15)  2013/05
• 肝胆膵外科における内視鏡下手術の利点とピットフォール

  味木 徹夫; 岡崎 太郎; 新関 亮; 松本 逸平; 後藤 直大; 浅利 貞毅; 木戸 正浩; 福本 巧; 具 英成  Medical Photonics  (13)  11  -15  2013/04
• PS-103-4 肝外胆管癌に対する肝外胆管切除の治療成績(PS ポスターセッション,第113回日本外科学会定期学術集会)

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 大坪 出; 村上 冴; 吉田 優子; 浅利 貞毅; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  114-  (2)  663  -663  2013/03
• PS-094-2 肝細胞癌患者におけるPHLFの検討 : 新たな肝予備能評価方法の立案にむけて(PS ポスターセッション,第113回日本外科学会定期学術集会)

  福島 健司; 蔵満 薫; 福本 巧; 浦出 剛史; 中馬 正志; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (2)  650  -650  2013/03
• PS-365-3 切除可能膵癌に対する術後補助化学療法の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

  田中 正樹; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 白川 幸代; 山下 博成; 岩崎 寿光; 石田 潤; 武部 敦志; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (2)  1032  -1032  2013/03
• PS-365-6 費用対効果からみた肝門部胆管癌切除例,非切除例の医療費の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

  味木 徹夫; 岡崎 太郎; 大坪 出; 村上 冴; 吉田 優子; 篠崎 健太; 木戸 正浩; 浅利 貞毅; 新関 亮; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  114-  (2)  1033  -1033  2013/03
• VF-016-4 肝胆道疾患におけるソナゾイドを用いた超音波下胆道造影による術中胆道ナビゲーションの有用性(VF ビデオフォーラム,第113回日本外科学会定期学術集会)

  浦出 剛史; 福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 中馬 正志; 福島 健司; 宗 慎一; 浅利 貞毅; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (2)  434  -434  2013/03
• VF-015-3 腹腔鏡下脾臓・脾動静脈温存膵体尾部切除術の適応と問題点(VF ビデオフォーラム,第113回日本外科学会定期学術集会)

  新関 亮; 松本 逸平; 石田 潤; 岩崎 寿光; 山下 博成; 白川 幸代; 田中 正樹; 後藤 直大; 浅利 貞毅; 武部 敦志; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (2)  433  -433  2013/03
• PS-341-4 肝移植医療のさらなる普及と脳死移植発展のために今必要とされること : 市中病院および移植施設における移植外科医の役割(PS ポスターセッション,第113回日本外科学会定期学術集会)

  武部 敦志; 福本 巧; 木戸 正治; 高橋 応典; 田中 基文; 蔵満 薫; 中馬 正志; 福島 健司; 浦出 剛史; 新関 亮; 松本 逸平; 味木 徹夫; 豊川 晃弘; 岩崎 武; 具 英成  日本外科学会雑誌  114-  (2)  999  -999  2013/03
• VF-078-2 高度門脈血栓合併症例に対する門脈再建術(VF ビデオフォーラム,第113回日本外科学会定期学術集会)

  中馬 正志; 小松 昇平; 木下 秘我; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (2)  494  -494  2013/03
• YT-6-5(YRA) 粘液産生胆管腫瘍(IPNB)からの細胞株樹立(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会)

  村上 冴; 味木 徹夫; 堀 裕一; 篠崎 健太; 吉田 優子; 大坪 出; 岡崎 太郎; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  114-  (2)  405  -405  2013/03
• PS-221-2 80歳以上の高齢者における肝細胞癌切除例の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

  田中 基文; 福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 中馬 正志; 浦出 剛史; 宋 慎一; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (2)  829  -829  2013/03
• PS-228-4 膵頭十二指腸切除術後出血例に対する治療選択と成績(PS ポスターセッション,第113回日本外科学会定期学術集会)

  後藤 直大; 松本 逸平; 新関 亮; 浅利 貞毅; 椋棒 英世; 田中 正樹; 白川 幸代; 山下 博成; 岩崎 寿光; 石田 潤; 武部 敦志; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (2)  839  -839  2013/03
• PS-222-1 2010年WHO分類に基づく膵神経内分泌腫瘍(pNET)の術後再発予測に関する検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

  山下 博成; 松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 白川 幸代; 田中 正樹; 岩崎 寿光; 石田 潤; 武部 敦志; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (2)  830  -830  2013/03
• 外科的治療限界の克服 スペーサー手術と粒子線治療の融合

  高橋 応典; 福本 巧; 木戸 正浩; 武部 敦史; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 中馬 正志; 福島 健司; 浦出 剛史; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; 出水 祐介; 寺嶋 千貴; 不破 信和; 具 英成  日本外科学会雑誌  114-  (臨増2)  386  -386  2013/03
• 高度門脈血栓合併症例に対する門脈再建術

  蔵満 薫; 福本 巧; 福島 健司; 宗 慎一; 浦出 剛史; 中馬 正志; 小松 昇平; 木下 秘我; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (臨増2)  494  -494  2013/03
• 肝細胞癌患者におけるPHLFの検討 新たな肝予備能評価方法の立案にむけて

  福島 健司; 蔵満 薫; 福本 巧; 浦出 剛史; 中馬 正志; 田中 基文; 武部 敦志; 高橋 応典; 木戸 正浩; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (臨増2)  650  -650  2013/03
• 80歳以上の高齢者における肝細胞癌切除例の検討

  田中 基文; 福本 巧; 木戸 正浩; 高橋 応典; 武部 敦志; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 中馬 正志; 浦出 剛史; 宋 慎一; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (臨増2)  829  -829  2013/03
• 肝移植医療のさらなる普及と脳死移植発展のために今必要とされること 市中病院および移植施設における移植外科医の役割

  武部 敦志; 福本 巧; 木戸 正治; 高橋 応典; 田中 基文; 蔵満 薫; 中馬 正志; 福島 健司; 浦出 剛史; 新関 亮; 松本 逸平; 味木 徹夫; 豊川 晃弘; 岩崎 武; 具 英成  日本外科学会雑誌  114-  (臨増2)  999  -999  2013/03
• 膵頭十二指腸切除術後出血例に対する治療選択と成績

  Goto Tadahiro; 松本 逸平; 新関 亮; Asari Sadaki; 椋棒 英世; 田中 正樹; 白川 幸代; 山下 博成; 岩崎 寿光; 石田 潤; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (臨増2)  839  -839  2013/03  [Refereed]
  
• 腹腔鏡下脾臓・脾動静脈温存膵体尾部切除術の適応と問題点

  新関 亮; 松本 逸平; 石田 潤; 岩崎 寿光; 山下 博成; 白川 幸代; 田中 正樹; Goto Tadahiro; Asari Sadaki; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (臨増2)  433  -433  2013/03  [Refereed]
  
• 費用対効果からみた肝門部胆管癌切除例、非切除例の医療費の検討

  味木 徹夫; 岡崎 太郎; 大坪 出; 村上 冴; 吉田 優子; 篠崎 健太; 木戸 正浩; Asari Sadaki; 新関 亮; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  114-  (臨増2)  1033  -1033  2013/03  [Refereed]
  
• 当科における成人生体肝移植後胆道合併症の現状

  木戸 正浩; 福本 巧; 高橋 応典; Takebe Atsushi; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 福島 健司; 浦出 剛史; 宗 慎一; 味木 徹夫; 松本 逸平; 新関 亮; 岡崎 太郎; Asari Sadaki; 具 英成  日本外科学会雑誌  114-  (臨増2)  992  -992  2013/03  [Refereed]
  
• 超高齢者胆道癌に対する治療成績

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 大坪 出; 村上 冴; 吉田 優子; 新関 亮; Asari Sadaki; Goto Tadahiro; 田中 正樹; 白川 幸代; 岩崎 寿光; 石田 潤; 松本 逸平; 木戸 正浩; 福本 巧; 具 英成  日本外科学会雑誌  114-  (臨増2)  674  -674  2013/03  [Refereed]
  
• 切除可能膵癌に対する術後補助化学療法の検討

  田中 正樹; 松本 逸平; 新関 亮; Asari Sadaki; Goto Tadahiro; 椋棒 英世; 白川 幸代; 山下 博成; 岩崎 寿光; 石田 潤; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (臨増2)  1032  -1032  2013/03  [Refereed]
  
• 肝胆道疾患におけるソナゾイドを用いた超音波下胆道造影による術中胆道ナビゲーションの有用性

  浦出 剛史; 福本 巧; 木戸 正浩; 高橋 応典; Takebe Atsushi; 田中 基文; 蔵満 薫; 木下 秘我; 小松 昇平; 中馬 正志; 福島 健司; 宗 慎一; Asari Sadaki; 岡崎 太郎; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  114-  (臨増2)  434  -434  2013/03  [Refereed]
  
• 肝外胆管癌に対する肝外胆管切除の治療成績

  岡崎 太郎; 味木 徹夫; 篠崎 健太; 大坪 出; 村上 冴; 吉田 優子; Asari Sadaki; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  114-  (臨増2)  663  -663  2013/03  [Refereed]
  
• 2010年WHO分類に基づく膵神経内分泌腫瘍(pNET)の術後再発予測に関する検討

  山下 博成; 松本 逸平; 新関 亮; Asari Sadaki; Goto Tadahiro; 椋棒 英世; 白川 幸代; 田中 正樹; 岩崎 寿光; 石田 潤; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  114-  (臨増2)  830  -830  2013/03  [Refereed]
  
• Randomized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 for patients with resected pancreatic cancer (JASPAC-01 study)

  Katsuhiko Uesaka; Akira Fukutomi; Narikazu Boku; Hideyuki Kanemoto; Masaru Konishi; Ippei Matsumoto; Yuji Kaneoka; Yasuhiro Shimizu; Shoji Nakamori; Hirohiko Sakamoto; Soichiro Morinaga; Osamu Kainuma; Koji Imai; Naohiro Sata; Shoichi Hishinuma; Takayuki Nakamura; Michio Kanai; Satoshi Hirano; Yukinobu Yoshikawa; Yasuo Ohashi  JOURNAL OF CLINICAL ONCOLOGY  31-  (4)  2013/02
• 陽子線治療を行った局所進行切除不能膵癌の2剖検例

  Goto Tadahiro; 松本 逸平; 寺嶋 千貴; 新関 亮; Asari Sadaki; 椋棒 英世; 田中 正樹; 白川 幸代; 山下 博成; 岩崎 寿光; 石田 潤; 岡崎 太郎; 高橋 応典; 木戸 正浩; 味木 徹夫; 福本 巧; 伊藤 智雄; 不破 信和; 村上 昌雄; 具 英成  日本消化器病学会雑誌  110-  (臨増総会)  A375  -A375  2013/02  [Refereed]
  
• IPMN切除例における浸潤・リンパ節転移予測因子の検討

  新関 亮; 松本 逸平; 石田 潤; 岩崎 寿光; 山下 博成; 白川 幸代; 田中 正樹; Goto Tadahiro; Asari Sadaki; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本消化器病学会雑誌  110-  (臨増総会)  A216  -A216  2013/02  [Refereed]
  
• ERCPによる重症急性膵炎発症後の膵頭部悪性腫瘍手術症例の検討

  Goto Tadahiro; 松本 逸平; Asari Sadaki; 新関 亮; 石田 潤; 岩崎 寿光; 白川 幸代; 山下 博成; 田中 正樹; 篠崎 健太; 吉田 優子; 村上 冴; 大坪 出; Takebe Atsushi; 高橋 応典; 岡崎 太郎; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本腹部救急医学会雑誌  33-  (2号)  386  -386  2013/02  [Refereed]
  
• 誌上ディベート IPMNの手術適応をめぐって 積極的に手術を進めるべきとする立場から

  松本 逸平; 新関 亮; 浅利 貞毅; 後藤 直大; 椋棒 英世; 白川 幸代; 田中 正樹; 山下 博成; 岩崎 寿光; 石田 潤; 岡崎 太郎; 味木 徹夫; 福本 巧; 具 英成  Frontiers in Gastroenterology  18-  (1)  26  -32  2013/01
• 【癌治療の選択-治療効果と治療費】 胆道癌の治療効果と治療費

  味木 徹夫; 岡崎 太郎; 大坪 出; 村上 冴; 吉田 優子; 篠崎 健太; 松本 逸平; 福本 巧; 具 英成  外科  75-  (1)  49  -53  2013/01
• 十二指腸潰瘍が原因と考えられたGroove pancreatitisの1例

  家本 孝雄; 塩見 英之; 増田 充弘; 佐貫 毅; 久津見 弘; 早雲 孝信; 新関 亮; 松本 逸平; 具 英成; 神澤 真紀; 原 重雄; 東 健  日本消化器病学会雑誌  110-  (1)  88  -94  2013/01
• 【手術前に必読 局所解剖】 肝・胆・膵・脾の手術 胆嚢癌手術に必要な局所解剖

  味木 徹夫; 岡崎 太郎; 松本 逸平; 福本 巧; 具 英成  外科  74-  (12)  1386  -1389  2012/11
• 術前経皮的肝灌流化学療法と肝切除にて完全奏効した両葉多発肝細胞癌の1例

  浦出 剛史; 田中 基文; 福本 巧; 木戸 正浩; 土田 忍; 高橋 応典; 武部 敦志; 蔵満 薫; 粟津 正英; 中馬 正志; 福島 健司; 宗 慎一; 田井 謙太郎; 藤本 将人; 外山 博近; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  癌と化学療法  39-  (12)  1825  -1827  2012/11
• ダブルバルーン内視鏡で確定診断し治療した術後再発胆管癌の3例

  篠崎 健太; 味木 徹夫; 岡崎 太郎; 吉田 優子; 村上 冴; 大坪 出; 白川 幸代; 田中 正樹; 沢 秀博; 後藤 直大; 浅利 貞毅; 上野 公彦; 外山 博近; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 早雲 孝信; 具 英成  癌と化学療法  39-  (12)  1877  -1879  2012/11
• 膵癌術後肝転移に対する経皮的肝灌流化学療法(PIHP)の治療経験

  外山 博近; 松本 逸平; 新関 亮; 白川 幸代; 田中 正樹; 山下 博成; 味木 徹夫; 上野 公彦; 沢 秀博; 大坪 出; 村上 冴; 木戸 正浩; 福本 巧; 具 英成  癌と化学療法  39-  (12)  1886  -1888  2012/11
• 硬化性胆管炎合併胆管癌に化学療法を行い長期生存した2例

  大坪 出; 味木 徹夫; 岡崎 太郎; 篠崎 健太; 吉田 優子; 村上 冴; 新関 亮; 木戸 正浩; 松本 逸平; 福本 巧; 具 英成  癌と化学療法  39-  (12)  2122  -2124  2012/11
• 膵癌Gemcitabine併用陽子線療法後に発症した間質性肺炎の1例

  田中 正樹; 松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 白川 幸代; 山下 博成; 沢 秀博; 上野 公彦; 高橋 応典; 土田 忍; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  癌と化学療法  39-  (12)  2158  -2160  2012/11
• Long-Term Outcomes and Prognostic Factors with Reductive Hepatectomy and Sequential Percutaneous Isolated Hepatic Perfusion for Multiple Bilobar Hepatocellular Carcinoma

  Takumi Fukumoto; Masahiro Kido; Masanori Takahashi; Atsushi Takebe; Motofumi Tanaka; Kaori Kuramitsu; Kenji Fukushima; Takeshi Urade; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku  HEPATOLOGY  56-  518A  -519A  2012/10
• Fragility Index, a Novel Predictor to Assess Deterioration Speed of Renal Function after Living Donor Liver Transplantation

  Kaori Kuramitsu; Takumi Fukumoto; Kenji Fukushima; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku  HEPATOLOGY  56-  519A  -519A  2012/10
• 【化学療法の進歩に伴う進行膵胆道癌の手術適応】 非切除胆道癌に対し化学療法施行後に切除に至った症例の検討

  味木 徹夫; 岡崎 太郎; 村上 冴; 吉田 優子; 篠崎 健太; 大坪 出; 松本 逸平; 福本 巧; 具 英成  癌の臨床  58-  (5)  273  -279  2012/10
• 【非切除胆道癌の治療】 胆道癌に対するR2手術+化学療法

  味木 徹夫; 岡崎 太郎; 上野 公彦; 村上 冴; 吉田 優子; 松本 逸平; 福本 巧; 具 英成  消化器内科  55-  (3)  372  -375  2012/09
• 鏡視下手術用臓器圧排器具エンドラクターの腹腔鏡下肝切除術における有用性

  土田 忍; 福本 巧; 楠 信也; 木戸 正浩; 高橋 応典; 田中 基文; 松本 逸平; 味木 徹夫; 濱口 武之; 具 英成  日本消化器外科学会総会  67回-  2  -2  2012/07
• 進行再発肝癌に対する治療戦略

  木戸 正浩; 福本 巧; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 味木 徹夫; 松本 逸平; 新関 亮; 具 英成  日本消化器外科学会総会  67回-  1  -1  2012/07
• 肝機能からみた肝細胞癌に対する治療戦略 肝癌根治的治療域の拡大 幕内基準を超えた肝切除の可能性

  福本 巧; 木戸 正浩; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 松本 逸平; 味木 徹夫; 具 英成  日本消化器外科学会総会  67回-  2  -2  2012/07
• 肝障害の少ない肝切除の工夫と周術期管理 左葉を用いた成人生体肝移植における残肝還流障害を回避可能な術式選択

  蔵満 薫; 福本 巧; 福島 健司; 田中 基文; 高橋 応典; 木戸 正浩; 土田 忍; 松本 逸平; 味木 徹夫; 具 英成  日本消化器外科学会総会  67回-  2  -2  2012/07
• 膵頭十二指腸切除術後出血 救命のための対策

  外山 博近; 松本 逸平; 新関 亮; Asari Sadaki; Goto Tadahiro; 白川 幸代; 山下 博成; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会67回  67回-  1  -1  2012/07  [Refereed]
  
• 良低悪性度膵疾患に対する腹腔鏡下膵切除術の術前診断と適応

  松本 逸平; 新関 亮; 外山 博近; Asari Sadaki; Goto Tadahiro; 白川 幸代; 上野 公彦; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会67回  67回-  1  -1  2012/07  [Refereed]
  
• 慢性肝疾患例における膵頭十二指腸切除術後合併症の検討

  白川 幸代; 松本 逸平; 外山 博近; 新関 亮; Asari Sadaki; Goto Tadahiro; 木戸 正浩; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会67回  67回-  1  -1  2012/07  [Refereed]
  
• 超高齢者膵癌に対する治療選択と切除成績

  Goto Tadahiro; 松本 逸平; 外山 博近; 新関 亮; Asari Sadaki; 土田 忍; 木戸 正浩; 福本 巧; 味木 徹夫; 具 英成  日本消化器外科学会総会67回  67回-  1  -1  2012/07  [Refereed]
  
• 進行膵癌に対する術後補助化学療法の成績と問題点

  田中 正樹; 松本 逸平; 新関 亮; 外山 博近; Asari Sadaki; Goto Tadahiro; 白川 幸代; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会67回  67回-  1  -1  2012/07
• 術前ERCPによる重症急性膵炎発症後手術を施行した膵頭部悪性腫瘍の検討

  Asari Sadaki; 松本 逸平; 新関 亮; 外山 博近; Goto Tadahiro; 沢 秀博; 上野 公彦; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会総会67回  67回-  2  -2  2012/07
• 【肝・胆・膵腫瘍の薬物療法-最近の進歩】 胆道がん 術後補助療法の現状と課題

  味木 徹夫; 上野 公彦; 岡崎 太郎; 松本 逸平; 福本 巧; 具 英成  腫瘍内科  9-  (6)  688  -691  2012/06
• 【膵癌update 2012】 治療 最新の膵癌粒子線治療

  新関 亮; 松本 逸平; 寺嶋 千貴; 白川 幸代; 外山 博近; 浅利 貞毅; 味木 徹夫; 福本 巧; 村上 昌雄; 具 英成  外科  74-  (5)  530  -534  2012/05
• 【膵疾患診療におけるFDG-PETの有用性】 膵癌に対する陽子線治療効果判定におけるFDG-PETの有用性

  白川 幸代; 松本 逸平; 寺嶋 千貴; 外山 博近; 新関 亮; 味木 徹夫; 福本 巧; 村上 昌雄; 具 英成  胆と膵  33-  (5)  427  -432  2012/05
• Advanced Intraductal Papillary Neoplasm of Bile Duct (IPNB) in a young female with metastases to lymph nodes and ovary

  YOSHIDA Yuko; AJIKI Tetsuo; UENO Kimihiko; OHTSUBO Izuru; MURAKAMI Sae; SHINOZAKI Kenta; MATSUMOTO Ippei; FUKUMOTO Takumi; KU Yonson; KANZAWA Maki; ITOH Tomoo  J.J.B.A  26-  (2)  231  -236  2012/05
• ゲムシタビン併用陽子線治療を行い3年以上の生存が得られている局所進行切除不能膵癌の1例

  松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 白川 幸代; 田中 正樹; 山下 博成; 味木 徹夫; 福本 巧; 具 英成; 寺嶋 千貴; 村上 昌雄  膵・胆道癌Frontier  2-  (1)  46  -47  2012/03
• 【十二指腸乳頭部癌-診断・治療の最前線-】 早期乳頭部癌の臨床的特徴と治療

  大坪 出; 味木 徹夫; 上野 公彦; 沢 秀博; 松本 逸平; 福本 巧; 塩見 英之; 増田 充弘; 久津見 弘; 具 英成  胆と膵  33-  (3)  249  -254  2012/03
• A carcinosarcoma of the extrahepatic bile duct

  Kenta Shinozaki; Tetsuo Ajiki; Taro Okazaki; Hidehiro Sawa; Kimihiko Ueno; Masahiro Kido; Ippei Matsumoto; Takumi Fukumoto; Tomoo Itoh; Yonson Ku  Japanese Journal of Gastroenterological Surgery  45-  (3)  282  -289  2012
• 【胆道がん治療の最新知識】 術後補助化学療法の有効性をめぐって

  松本 逸平; 味木 徹夫; 具 英成  臨床腫瘍プラクティス  7-  (4)  374  -376  2011/11
• 【外科医が知っておくべき徴候と症候群】 胆道 Lemmel症候群とMirizzi症候群

  上野 公彦; 味木 徹夫; 松本 逸平; 福本 巧; 具 英成  外科  73-  (12)  1396  -1400  2011/11
• 肝切除および粒子線治療併用にて治療効果を認めた両葉多発肝細胞癌の1例

  浦出 剛史; 木戸 正浩; 福本 巧; 堀 裕一; 楠 信也; 土田 忍; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 権 英寿; 中馬 正志; 福島 健司; 松本 逸平; 味木 徹夫; 寺嶋 千貴; 出水 祐介; 村上 昌雄; 具 英成  癌と化学療法  38-  (12)  2065  -2067  2011/11
• 【膵癌診療と研究の最先端】 局所進行膵癌に対するGemcitabine併用陽子線治療

  寺嶋 千貴; 出水 祐介; 松本 逸平; 白川 幸代; 橋本 直樹; 美馬 正幸; 丹羽 康江; 藤井 收; 村上 昌雄  胆と膵  32-  (9)  863  -868  2011/09
• 【膵癌診療と研究の最先端】粒子線治療を用いた新しい膵癌治療戦略

  松本 逸平; 福本 巧; 寺嶋 千貴; 白川 幸代; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 神垣 隆; 村上 昌雄; 具 英成  胆と膵  32-  (9)  869  -874  2011/09
• 嚢胞成分を伴い診断困難であったStage I浸潤性膵管癌の1例

  松本 逸平; 白川 幸代; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 山下 博成; 田中 正樹; 木戸 正浩; 楠 信也; 堀 裕一; 福本 巧; 味木 徹夫; 伊藤 智雄; 具 英成  膵臓  26-  (4)  511  -516  2011/08
• 先天性胆道拡張症術後12年目に発症した肝門部胆管癌の1例

  中馬 正志; 味木 徹夫; 上野 公彦; 松本 逸平; 福本 巧; 具 英成  日本臨床外科学会雑誌  72-  (6)  1531  -1535  2011/06
• PS-098-7 胆管癌における肝外胆管切除症例の検討(PS-098 ポスターセッション(98)胆管:悪性-1,第111回日本外科学会定期学術集会)

  沢 秀博; 味木 徹夫; 山田 勇; 上野 公彦; 大坪 出; 後藤 直大; 浅利 貞毅; 新関 亮; 外山 博近; 木戸 正浩; 松本 逸平; 土田 忍; 楠 信也; 鈴木 智志; 福本 巧; 堀 裕一; 黒田 大介; 具 英成  日本外科学会雑誌  112-  (1)  675  -675  2011/05
• PS-099-1 胆道再建術に対する胆道再々建術の検討(PS-099 ポスターセッション(99)胆管:悪性-2,第111回日本外科学会定期学術集会)

  上野 公彦; 味木 徹夫; 大坪 出; 沢 秀博; 山田 勇; 白川 幸代; 後藤 直大; 浅利 貞毅; 外山 博近; 新関 亮; 木戸 正浩; 土田 忍; 松本 逸平; 鈴木 知志; 楠 信也; 黒田 大介; 堀 裕一; 福本 巧; 具 英成  日本外科学会雑誌  112-  (1)  675  -675  2011/05
• PS-211-2 IPMNに対する縮小・低侵襲手術(PS-211 ポスターセッション(211)膵臓:悪性・診断-3,第111回日本外科学会定期学術集会)

  山下 博成; 松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 白川 幸代; 田中 正樹; 澤 秀博; 上野 公彦; 土田 忍; 山田 勇; 鈴木 知志; 木戸 正浩; 黒田 大介; 楠 信也; 堀 裕一; 福本 巧; 味木 徹夫; 具 英成  日本外科学会雑誌  112-  (1)  871  -871  2011/05
• PS-158-2 上部胃癌における脾臓合併切除の意義と,脾門部リンパ節の位置づけについての検討(PS-158 ポスターセッション(158)胃:手術-8,第111回日本外科学会定期学術集会)

  金光 聖哲; 長谷川 寛; 大坪 大; 松田 佳子; 安田 貴志; 山下 公大; 今西 達也; 角 泰雄; 中村 哲; 木戸 正浩; 松本 逸平; 鈴木 知志; 味木 徹夫; 堀 裕一; 福本 巧; 具 英成; 黒田 大介  日本外科学会雑誌  112-  (1)  779  -779  2011/05
• SF-055-2 肝門部胆管癌に対する切除適応拡大に向けた新展開(SF-055 サージカルフォーラム(55)胆管:手術-1,第111回日本外科学会定期学術集会)

  味木 徹夫; 上野 公彦; 山田 勇; 沢 秀博; 大坪 出; 木戸 正浩; 土田 忍; 楠 信也; 新関 亮; 外山 博近; 松本 逸平; 黒田 大介; 鈴木 知志; 堀 裕一; 福本 巧; 具 英成  日本外科学会雑誌  112-  (1)  404  -404  2011/05
• SF-051-3 Borderline resectable膵頭部癌の術前診断と切除意義の検討(SF-051 サージカルフォーラム(51)膵臓:診断,第111回日本外科学会定期学術集会)

  新関 亮; 松本 逸平; 外山 博近; 白川 幸代; 山下 博成; 田中 正樹; 後藤 直大; 沢 秀博; 浅利 貞毅; 木戸 正浩; 土田 忍; 上野 公彦; 鈴木 知志; 山田 勇; 楠 信也; 味木 徹夫; 福本 巧; 堀 裕一; 黒田 大介; 具 英成  日本外科学会雑誌  112-  (1)  399  -399  2011/05
• VW-4-11 亜全胃温存膵頭十二指腸切除術(SSPPD)における再建術の工夫(VW4 ビデオワークショップ(4) 肝胆膵手術-合併症を防ぐ工夫,第111回日本外科学会定期学術集会)

  松本 逸平; 浅利 貞毅; 新関 亮; 外山 博近; 後藤 直大; 白川 幸代; 山下 博成; 澤 秀博; 上野 公彦; 山田 勇; 土田 忍; 木戸 正浩; 鈴木 和志; 楠 信也; 福本 巧; 堀 裕一; 黒田 大介; 味木 徹夫; 具 英成  日本外科学会雑誌  112-  (1)  314  -314  2011/05
• PS-172-2 大腸癌肝転移に対する肝切除における術前化学療法の影響(PS-172 ポスターセッション(172)肝臓:手術-2,第111回日本外科学会定期学術集会)

  楠 信也; 福本 巧; 土田 忍; 木戸 正浩; 高橋 応典; 田中 基文; 蔵満 薫; 津川 大介; 粟津 正英; 片岡 庸子; 中馬 正志; 松本 逸平; 味木 徹夫; 堀 裕一; 鈴木 知志; 黒田 大介; 具 英成  日本外科学会雑誌  112-  (1)  804  -804  2011/05
• PS-177-7 胃切除後膵頭十二指腸切除術例の検討(PS-177 ポスターセッション(177)膵臓:手術-2,第111回日本外科学会定期学術集会)

  後藤 直大; 松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 白川 幸代; 山下 博成; 上野 公彦; 土田 忍; 山田 勇; 鈴木 知志; 木戸 正浩; 黒田 大介; 福本 巧; 楠 信也; 堀 裕一; 福本 巧; 味木 徹夫; 具 英成  日本外科学会雑誌  112-  (1)  814  -814  2011/05
• PS-138-5 肝門部胆管癌における術前ドレナージ法と周術期合併症との関連の検討(PS-138 ポスターセッション(138)胆管:悪性-3,第111回日本外科学会定期学術集会)

  吉田 優子; 味木 徹夫; 大坪 出; 沢 秀博; 上野 公彦; 山田 勇; 外山 博近; 新関 亮; 木戸 正浩; 松本 逸平; 楠 信也; 黒田 大介; 福本 巧; 堀 裕一; 具 英成  日本外科学会雑誌  112-  (1)  744  -744  2011/05
• PS-141-4 膵腫瘍核出術の手技と成績(PS-141 ポスターセッション(141)膵臓:良性,第111回日本外科学会定期学術集会)

  田中 正樹; 松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 白川 幸代; 山下 博成; 澤 秀博; 上野 公彦; 山田 勇; 土田 忍; 木戸 正浩; 楠 信也; 鈴木 和志; 黒田 大介; 福本 巧; 堀 裕一; 味木 徹夫; 具 英成  日本外科学会雑誌  112-  (1)  750  -750  2011/05
• PS-037-7 内視鏡外科をとりまく手術環境の整備 : 当院での取り組みについて(PS-037 ポスターセッション(37)教育・その他,第111回日本外科学会定期学術集会)

  中村 哲; 大坪 大; 長谷川 寛; 金光 聖哲; 安田 貴志; 松田 佳子; 山下 公大; 今西 達也; 角 泰雄; 木戸 正浩; 松本 逸平; 鈴木 知志; 味木 徹夫; 福本 巧; 黒田 大介; 具 英成  日本外科学会雑誌  112-  (1)  570  -570  2011/05
• PS-070-2 膵頭十二指腸切除術後肝動脈出血の臨床経過とマネージメント(PS-070 ポスターセッション(70)膵臓:周術期管理・合併症-2,第111回日本外科学会定期学術集会)

  外山 博近; 松本 逸平; 新関 亮; 白川 幸代; 浅利 貞毅; 後藤 直大; 山下 博成; 田中 正樹; 上野 公彦; 山田 勇; 沢 秀博; 大坪 出; 土田 忍; 鈴木 知志; 木戸 正浩; 楠 信也; 黒田 大介; 堀 裕一; 味木 徹夫; 福本 巧; 具 英成  日本外科学会雑誌  112-  (1)  625  -625  2011/05
• 【胆道癌に対する最新の集学的治療】 胆道癌に対する減量切除と至適抗癌剤投与による治療戦略

  Ajiki Tetsuo; Matsumoto Ippei  消化器内科  52巻, 4号, pp. 437-442-  (4)  437  -442  2011/04
• 膵切除後に残膵に再燃をきたした自己免疫性膵炎の2例

  井上 潤; 増田 充弘; 斉藤 雅也; 斧山 美津子; 塩見 英之; 外山 博近; 新関 亮; 松本 逸平; 林 祥剛; 牧野 哲哉; 多田 秀敏; 久津見 弘; 具 英成; 東 健  日本消化器病学会雑誌  108-  (4)  640  -649  2011/04
• 【膵臓・膵島移植の現況と最新の研究】 膵臓・膵島移植における臓器保存法

  松本 逸平; 新関 亮; 外山 博近; 浅利 貞毅; 後藤 直大; 福本 巧; 具 英成  膵臓  26-  (2)  142  -152  2011/04
• 【肝胆膵領域における最新の画像診断】 肝胆膵領域におけるFDG-PETの役割

  松本 逸平; 白川 幸代; 山田 勇; 外山 博近; 新関 亮; 味木 徹夫; 福本 巧; 具 英成  外科  73-  (2)  187  -195  2011/02
• 重症急性壊死性膵炎を発症し内視鏡的乳頭括約筋切開術を行ったLemmel症候群の1例

  新関 亮; 堀 裕一; 松本 逸平; 白川 幸代; 椋棒 英世; 外山 博近; 味木 徹夫; 福本 巧; 具 英成  日本消化器外科学会雑誌  44-  (2)  123  -130  2011/02
• 膵頭十二指腸切除術後反復性胆管炎に対し消化管経路変更術が有用であった1例

  後藤 直大; 松本 逸平; 新関 亮; 外山 博近; 味木 徹夫; 具 英成  日本消化器外科学会雑誌  44-  (1)  44  -50  2011/01
• 妊娠を契機に発見された膵粘液性嚢胞腫瘍の2例

  白川 幸代; 松本 逸平; 中山 俊二; 椋棒 英世; 外山 博近; 新関 亮; 福本 巧; 味木 徹夫; 具 英成  日本消化器病学会雑誌  107-  (11)  1828  -1834  2010/11
• 肝切除と経皮的肝灌流(PIHP)の2段階治療(Dual Tx)が奏効したVp4門脈腫瘍栓(PVTT)を伴う肝細胞癌(HCC)の1例

  中馬 正志; 福本 巧; 楠 信也; 土田 忍; 木戸 正浩; 高橋 応典; 津川 大介; 粟津 正英; 片岡 庸子; 松本 逸平; 堀 裕一; 黒田 大介; 具 英成  癌と化学療法  37-  (12)  2300  -2302  2010/11
• 肝細胞癌術後リンパ節再発に対しリンパ節切除術と経皮的肝灌流化学療法を施行し長期生存を得た1例

  津川 大介; 福本 巧; 楠 信也; 土田 忍; 千堂 宏義; 木戸 正浩; 高橋 応典; 武部 敦志; 粟津 正英; 片岡 庸子; 松本 逸平; 味木 徹夫; 堀 裕一; 鈴木 知志; 黒田 大介; 具 英成  癌と化学療法  37-  (12)  2312  -2314  2010/11
• スペーサー手術と粒子線治療による2段階治療が有効であった仙骨脊索腫の1例

  高橋 応典; 福本 巧; 楠 信也; 土田 忍; 木戸 正浩; 武部 敦志; 粟津 正英; 片岡 庸子; 松本 逸平; 味木 徹夫; 堀 裕一; 鈴木 知志; 黒田 大介; 村上 昌雄; 菱川 良夫; 具 英成  癌と化学療法  37-  (12)  2804  -2806  2010/11
• NEW SURGICAL OPTIONS FOR PATIENTS WITH HUGE (> 10CM) HEPATOCELLULAR CARCINOMA: SIGNIFICANT ROLE OF REDUCTIVE SURGERY

  Daisuke Tsugawa; Takumi Fukumoto; Nobuya Kusunoki; Masahiro Kido; Shinobu Tsuchida; Masanori Takahashi; Masahide Awazu; Youko Kataoka; Ippei Matsumoto; Tetsuo Ajiki; Yuichi Hori; Satoshi Suzuki; Daisuke Kuroda; Yonson Ku  HEPATOLOGY  52-  (4)  1184A  -1184A  2010/10
• 妊娠20週妊婦の胆石胆嚢炎に対して腹腔鏡下胆嚢摘出術を施行した1例

  友野 絢子; 岡崎 太郎; 松本 逸平; 味木 徹夫; 具 英成  日本腹部救急医学会雑誌  30-  (6)  835  -838  2010/09
• 【先端的画像支援による肝胆道手術】 3D-CT 3D-CT胆管バーチャル画像支援による肝門部胆管癌手術

  平田 建郎; 味木 徹夫; 上野 公彦; 松本 逸平; 福本 巧; 具 英成  手術  64-  (9)  1237  -1242  2010/08
• 【手術機器の使い方 基本と応用】 開腹手術用機器 鉗子

  松本 逸平; 福本 巧; 具 英成  手術  64-  (6)  723  -727  2010/05
• 【外科当直医必携】 救急外来当直医必携 症状別の初療と診断のすすめ方 呼吸困難

  松本 逸平; 味木 徹夫; 具 英成  消化器外科  33-  (5)  650  -652  2010/04
• OP-168-6 当院における巨大肝細胞癌に対する切除成績の検討 : 減量切除の意義について(肝癌-2,一般口演,第110回日本外科学会定期学術集会)

  津川 大介; 福本 巧; 楠 信也; 木戸 正浩; 千堂 宏義; 高橋 応典; 武部 敦志; 小松 昇平; 片岡 庸子; 松本 逸平; 味木 徹夫; 堀 裕一; 神垣 隆; 黒田 大介; 具 英成  日本外科学会雑誌  111-  (2)  549  -549  2010/03
• Successful management of ruptured pseudoaneurysm of superior mesenteric artery(SMA) after pancreatoduodenectomy by SMA-iliac artery bypass grafting; Report of a case

  Hideyo Mukubou; Ippei Matsumoto; Sachiyo Shirakawa; Hirochika Toyama; Makoto Shinzeki; Toshiaki Tsujimura; Tetsuo Ajiki; Yuichi Hori; Takumi Fukumoto; Yonson Ku  Japanese Journal of Gastroenterological Surgery  43-  (5)  548  -553  2010
• P-3-312 膵体尾部腫瘍に対するHand-assisted distal pancreatectomy(膵 縮小手術,一般演題(ポスター),第64回日本消化器外科学会総会)

  松本 逸平; 新関 亮; 外山 博近; 辻村 敏明; 木戸 正浩; 楠 信也; 味木 徹夫; 福本 巧; 堀 裕一; 具 英成  日本消化器外科学会雑誌  42-  (7)  1333  -1333  2009/07
• P-3-316 膵中央切除の手術手技と成績(膵 縮小手術,一般演題(ポスター),第64回日本消化器外科学会総会)

  外山 博近; 松本 逸平; 新関 亮; 辻村 敏明; 寺井 祥雄; 椋棒 英世; 味木 徹夫; 岡崎 太郎; 福本 巧; 具 英成  日本消化器外科学会雑誌  42-  (7)  1334  -1334  2009/07
• PD-4-8 Vp3,4を伴う超高度進行肝細胞癌に対する治療戦略 : 神戸二段階療法(パネルディスカッション4 脈管侵襲陽性肝癌に対する治療戦略,第64回日本消化器外科学会総会)

  木戸 正浩; 福本 巧; 堀 裕一; 味木 徹夫; 村松 三四郎; 楠 信也; 松本 逸平; 千堂 宏義; 武部 敦志; 具 英成  日本消化器外科学会雑誌  42-  (7)  961  -961  2009/07
• P-2-500 代謝酵素発現からみた胆道癌gemcitabine奏効例の選別(胆 手術・集学的治療,一般演題(ポスター),第64回日本消化器外科学会総会)

  森本 大樹; 味木 徹夫; 藤田 恒憲; 岡崎 太郎; 松本 拓; 平田 建郎; 山田 勇; 新関 亮; 松本 逸平; 具 英成  日本消化器外科学会雑誌  42-  (7)  1265  -1265  2009/07
• O-2-48 根治切除不能肝門部胆管癌に対する外科集学的先端戦略の展開(企画関連口演27 肝門部胆管癌,第64回日本消化器外科学会総会)

  味木 徹夫; 岡崎 太郎; 福本 巧; 森本 大樹; 山田 勇; 松本 逸平; 新関 亮; 木戸 正浩; 楠 信也; 具 英成  日本消化器外科学会雑誌  42-  (7)  1088  -1088  2009/07
• SF-003-2 膵癌細胞を用いた化学放射線照射による細胞死のautophagy寄与に関する基礎的検討(膵(基礎研究2),サージカルフォーラム,第109回日本外科学会定期学術集会)

  椋棒 英世; 辻村 敏明; 佐々木 良平; 寺井 祥雄; 外山 博近; 新関 亮; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  110-  (2)  227  -227  2009/02
• HP-146-6 肝門部胆管癌に対するENBDを用いた胆管造影下3D-CTによる切離線決定(胆管(悪性1),ハイブリッドポスター,第109回日本外科学会定期学術集会)

  岡崎 太郎; 味木 徹夫; 木戸 正浩; 尾形 哲; 森本 大樹; 新関 亮; 外山 博近; 松本 逸平; 楠 信也; 福本 巧; 具 英成  日本外科学会雑誌  110-  (2)  644  -644  2009/02
• IV-2-3 Hand-assisted laparoscopic distal pancreatectomy : its safety and efficacy in laparoscopic pancreatic surgery(Pancreatic surgery,International Video Teleconference)

  Matsumoto Ippei; Shinzeki Makoto; Toyama Hirochika; Tsujimura Toshiaki; Terai Sachio; Mukubou Hideyo; Kido Masahiro; Kusunoki Nobuya; Ajiki Tetsuo; Fukumoto Takumi; Ku Yonson  Journal of Japan Surgical Society  110-  (2)  72  -72  2009/02
• HP-216-5 超高度進行肝癌に対する新しい治療戦略 : 術前・術後経皮的肝灌流(PIHP)併用三段階療法(肝臓(肝がん治療2),ハイブリッドポスター,第109回日本外科学会定期学術集会)

  片岡 庸子; 福本 巧; 味木 徹夫; 村松 三四郎; 楠 信也; 松本 逸平; 千堂 宏義; 木戸 正浩; 尾形 哲; 文 宣貴; 木下 秘我; 小松 昇平; 粟津 正英; 岩崎 寿光; 具 英成  日本外科学会雑誌  110-  (2)  751  -751  2009/02
• HP-135-7 リンパ節転移陽性肝細胞癌に対する外科的切除の意義(肝臓(肝がん外科治療2),ハイブリッドポスター,第109回日本外科学会定期学術集会)

  粟津 正英; 福本 巧; 村松 三四郎; 楠 信也; 千堂 宏義; 木戸 正浩; 尾形 哲; 木下 秘我; 小松 昇平; 片岡 庸子; 岩崎 寿光; 松本 逸平; 味木 徹夫; 具 英成  日本外科学会雑誌  110-  (2)  625  -625  2009/02
• HP-144-2 切除不能胆嚢癌に対する集学的切除新戦略(胆嚢(悪性1),ハイブリッドポスター,第109回日本外科学会定期学術集会)

  味木 徹夫; 木戸 正浩; 岡崎 太郎; 森本 大樹; 尾形 哲; 楠 信也; 新関 亮; 外山 博近; 松本 逸平; 福本 巧; 具 英成  日本外科学会雑誌  110-  (2)  640  -640  2009/02
• Resection of gallbladder cancer with hepatic metastasis after chemotherapy with gemcitabine

  MORIMOTO HARUKI; AJIKI TETSUO; TAKASE SHIRO; FUJITA TSUNENORI; MATSUMOTO TAKU; MITA YOSHIYASU; MATSUMOTO IPPEI; FUJINO YASUHIRO; SUZUKI YASUYUKI; KURODA YOSHIKAZU; KU YONSON  J Hepatobiliary Pancreat Surg  15-  (6)  655  -658  2008/11
• Laparoscopic assisted distal pancreatectomy for a patient with main duct intraductal papillary mucinous adenocarcinoma

  MATSUMOTO Ippei; KURODA Daisuke; SHINZEKI Makoto; TOYAMA Hirochika; TSUJIMURA Toshiaki; KIM Yongsik; TAKASE Shiro; KIDO Masahiro; FUJITA Tsunenori; AJIKI Tetsuo; KURODA Yoshikazu; KU Yonson  Suizo  23-  (5)  594  -599  2008/10
• A CASE OF RHABDOMYOLYSIS AS A COMPLICATION OF GEMCITABINE CHEMOTHERAPY FOR BILIARY CANCER

  MORIMOTO Haruki; AJIKI Tetsuo; FUJITA Tsunenori; SHINZEKI Makoto; MATSUMOTO Ippei; KU Yonson  日本臨床外科学会雑誌 = The journal of the Japan Surgical Association  69-  (8)  2097  -2101  2008/08
• P-3-37 膵癌が否定できなかった自己免疫性膵炎に対し,膵中央切除術を施行した1例(膵炎,一般演題(ポスター),第63回日本消化器外科学会総会)

  寺井 祥雄; 松本 逸平; 椋棒 英世; 新関 亮; 外山 博近; 辻村 敏明; 味木 徹夫; 具 英成  日本消化器外科学会雑誌  41-  (7)  1523  -1523  2008/07
• O-2-300 膵癌の臨床におけるFDG/PETの的意義と問題点 : FDG/PETは膵癌の診断を変えるか(胆・膵 診断,一般演題(口演),第63回日本消化器外科学会総会)

  外山 博近; 松本 逸平; 新関 亮; 辻村 敏明; 寺井 祥雄; 椋棒 英世; 味木 徹夫; 藤田 恒憲; 平田 建郎; 具 英成  日本消化器外科学会雑誌  41-  (7)  1246  -1246  2008/07
• P-1-31 慢性膵炎に対するFrey手術後長期を経て肝膿瘍破裂を来した1例(胆・膵 症例1,一般演題(ポスター),第63回日本消化器外科学会総会)

  新関 亮; 松本 逸平; 外山 博近; 辻村 敏明; 椋棒 英世; 寺井 祥雄; 平田 建郎; 藤田 恒憲; 味木 徹夫; 具 英成  日本消化器外科学会雑誌  41-  (7)  1340  -1340  2008/07
• O-3-119 胆道癌におけるTS,DPD発現とS-1治療効果の相関についての検討(胆・膵 集学的治療2,一般演題(口演),第63回日本消化器外科学会総会)

  森本 大樹; 味木 徹夫; 藤田 恒憲; 岡崎 太郎; 松本 拓; 平田 建郎; 外山 博近; 新関 亮; 松本 逸平; 具 英成  日本消化器外科学会雑誌  41-  (7)  1285  -1285  2008/07
• O-3-116 非切除・再発胆道癌化学療法の治療効果判定における腫瘍マーカーの有用性(胆・膵 集学的治療1,一般演題(口演),第63回日本消化器外科学会総会)

  藤田 恒憲; 味木 徹夫; 平田 建郎; 岡崎 太郎; 松本 拓; 森本 大樹; 松本 逸平; 新関 亮; 外山 博近; 具 英成  日本消化器外科学会雑誌  41-  (7)  1285  -1285  2008/07
• O-3-97 膵頭十二指腸切除後膵液漏,出血のISGPF分類による再評価と合併症回避に向けた対策(胆・膵 PD再建7,一般演題(口演),第63回日本消化器外科学会総会)

  松本 逸平; 新関 亮; 外山 博近; 辻村 敏明; 椋棒 英世; 寺井 祥雄; 藤田 恒憲; 味木 徹夫; 黒田 嘉和; 具 英成  日本消化器外科学会雑誌  41-  (7)  1283  -1283  2008/07
• O-3-120 再発胆道癌に対する化学療法を中心とした治療成績(胆・膵 集学的治療2,一般演題(口演),第63回日本消化器外科学会総会)

  味木 徹夫; 藤田 恒憲; 森本 大樹; 岡崎 太郎; 松本 逸平; 新関 亮; 外山 博近; 福本 巧; 具 英成  日本消化器外科学会雑誌  41-  (7)  1285  -1285  2008/07
• RS-344 自験例からみた十二指腸乳頭部癌縮小手術の至適条件(要望演題22-1 十二指腸乳頭部癌に対する縮小手術とその適応1,第63回日本消化器外科学会総会)

  平田 建郎; 味木 徹夫; 藤田 恒憲; 岡崎 太郎; 森本 大樹; 松本 逸平; 外山 博近; 新関 亮; 福本 巧; 具 英成  日本消化器外科学会雑誌  41-  (7)  1139  -1139  2008/07
• Outcomes of gemcitabine treatment for invasive ductal pancreatic cancer

  Yasuhiro Fujino; Ippei Matsumoto; Hirotika Toyama; Shiro Takase; Takashi Kamigaki; Takashi Ueda; Yoshikazu Kuroda  PANCREAS  37-  (1)  112  -112  2008/07
• Analysis of pulmonary dysfunction complicating severe acute pancreatitis

  Hidehiro Sawa; Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Makoto Shinzeki; Naoki Matsumura; Takahiro Nakajima; Ippei Matsumoto; Tsunenori Fujita; Tetsuo Ajiki; Yasuhiro Fujino; Yoshikazu Kuroda  PANCREAS  37-  (1)  110  -110  2008/07
• Disorder of coagulation-fibrinolysis system in patients with severe acute pancreatitis

  Takahiro Nakajima; Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Makoto Shinzeki; Hidehiro Sawa; Ippei Matsumoto; Tsunenori Fujita; Tetsuo Ajiki; Yasuhiro Fujino; Yasuyuki Suzuki; Yoshikazu Kuroda  PANCREAS  37-  (1)  108  -108  2008/07
• Lymphoepithelial cyst of the pancreas: A preoperatively diagnosed case

  Yasuhisa Kamoda; Yasuhiro Fujino; Takashi Ueda; Takeo Yasuda; Ippei Matsumoto; Hirochika Toyama; Yoshikazu Kuroda  PANCREAS  37-  (1)  113  -113  2008/07
• A phase I study of proton beam therapy for locally advanced pancreatic cancer: Analysis of feasibility and anti-tumor effect

  T. Kamigaki; M. Murakami; I. Matsumoto; H. Toyama; T. Fujita; S. Takase; T. Sakai; T. Ajiki; Y. Ku; Y. Hishikawa; Y. Kuroda  JOURNAL OF CLINICAL ONCOLOGY  26-  (15)  2008/05
• DP-146-2 局所進行膵癌に対するgemcitabine膵動注療法の第I相試験の成績(第108回日本外科学会定期学術集会)

  新関 亮; 松本 逸平; 外山 博近; 辻村 敏明; 椋棒 英世; 寺井 祥雄; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 具 英成  日本外科学会雑誌  109-  (2)  636  -636  2008/04
• DP-018-7 術中胆道造影で検出された膵管内逆流現象についての検討(第108回日本外科学会定期学術集会)

  藤田 恒憲; 味木 徹夫; 平田 建郎; 松本 拓; 森本 大樹; 松本 逸平; 新関 亮; 外山 博近; 木戸 正浩; 福本 巧; 具 英成  日本外科学会雑誌  109-  (2)  381  -381  2008/04
• DP-010-3 膵島移植における膵島輸送方法の検討(第108回日本外科学会定期学術集会)

  寺井 祥雄; 辻村 敏明; 椋棒 英世; 新関 亮; 外山 博近; 松本 逸平; 李 世日; 具 英成  日本外科学会雑誌  109-  (2)  364  -364  2008/04
• Serum immunosuppressive acidic protein levels in patients with severe acute pancreatitis

  Makoto Shinzeki; Takashi Ueda; Yoshifumi Takeyama; Takeo Yasuda; Kenro Hirata; Hirochika Toyama; Ippei Matsumoto; Toshiaki Tsujimura; Tsunenori Fujita; Tetsuo Ajiki; Yonson Ku  GASTROENTEROLOGY  134-  (4)  A869  -A869  2008/04
• The incidence of other malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas: Emphasis on whole-body surveillance

  Ikuya Miki; Hiromu Kutsumi; Tetsuo Ajiki; Ippei Matsumoto; Shiei Yoshida; Yoshinori Morita; Takashi Toyonaga; Masaru Yoshida; Hideto Inokuchi; Shigeto Mizuno; Takeshi Azuma  GASTROENTEROLOGY  134-  (4)  A698  -A698  2008/04
• 当院で経験した膵管内乳頭粘液性腫瘍(IPMN)の他臓器癌の合併についての検討

  吉田 志栄; 三木 生也; 松本 逸平; 久津見 弘; 矢野 嘉彦; 森田 圭紀; 吉田 優; 瀬尾 靖; 田村 孝雄; 豊永 高史; 井口 秀人; 具 英成; 東 健  日本消化器病学会雑誌  105-  (臨増総会)  A260  -A260  2008/03
• State of the Art 両葉多発肝転移で発見された十二指腸カルチノイドの1例

  白川 幸代; 木戸 正浩; 文 宣貴; 木下 秘我; 松本 逸平; 富永 正寛; 岩崎 武; 福本 巧; 具 英成; 林 祥剛  肝胆膵画像  10-  (2)  167  -170  2008/03
• Gender differences in the prognostic factor of severe acute pancreatitis

  Takeo Yasuda; Takashi Ueda; Yoshifumi Takeyama; Makoto Shinseki; Hidehiro Sawa; Takahiro Nakajima; Ippei Matsumoto; Tetsuo Ajiki; Yonson Ku; Yoshikazu Kuroda  Japanese Journal of Gastroenterological Surgery  41-  (9)  1669  -1676  2008
• Impact of gemcitabine on the survival of patients with stage IV pancreatic cancer

  FUJINO Yasuhiro; UEDA Takashi; KAMIGAKI Takashi; TAKASE Shiro; AJIKI Tetsuo; KAMODA Yasuhisa; MATSUMOTO Ippei; YASUDA Takeo; KURODA Yoshikazu  膵臓 = The Journal of Japan Pancreas Society  22-  (5)  592  -594  2007/10
• Comparison of Treatment Outcome between Total Parenteral Nutrition and Enteral Nutrition in Patients with Severe Acute Pancreatitis

  SAWA Hidehiro; UEDA Takashi; TAKEYAMA Yoshifumi; YASUDA Takeo; SHINZEKI Makoto; NAKAJIMA Takahiro; MATSUMOTO Ippei; FUJITA Tsunenori; AJIKI Tetsuo; FUJINO Yasuhiro; KURODA Yoshikazu  外科と代謝・栄養  41-  (5)  143  -150  2007/10
• Efficacy of arterial calcium stimulation and hepatic venous sampling (ASVS) for regionalization of pancreatic insulinomas

  Ippei Matsumoto; Makoto Shinzeki; Hirochika Toyama; Toshiaki Tujimura; Hideo Mukubou; Sachio Terai; Tsunenori Fujita; Tetsuo Ajiki; Yoshikazu Kuroda; Yonson Ku  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  22-  A145  -A145  2007/10
• Islet transplantation from uncontrolled non-heart-beating donors: A single-center experience

  Toshiaki Tsujimura; Yasuki Tanioka; Tetsuya Sakai; Ippei Matsumoto; Sachio Terai; Yonson Ku; Yoshikazu Kuroda  TRANSPLANT INTERNATIONAL  20-  167  -167  2007/09
• Analysis of pulmonary dysfunction complicating severe acute pancreatitis

  SAWA Hidehiro; UEDA Takashi; TAKEYAMA Yoshifumi; YASUDA Takeo; SHINZEKI Makoto; MATSUMURA Naoki; NAKAJIMA Takahiro; MATSUMOTO Ippei; FUJITA Tsunenori; AJIKI Tetsuo; FUJINO Yasuhiro; KURODA Yoshikazu  Suizo  22-  (4)  470  -478  2007/08
• 左側胆嚢に対し腹腔鏡下胆嚢摘出術を施行した1例

  藤田 恒憲; 味木 徹夫; 松本 拓; 岡崎 太郎; 松本 逸平; 黒田 嘉和  日本内視鏡外科学会雑誌  12-  (4)  403  -407  2007/08
• RS-45 幽門輪温存・亜全胃温存膵頭十二指腸切除術の術後合併症および栄養状態の比較検討(要望演題10 膵合併症,第62回日本消化器外科学会定期学術総会)

  松本 逸平; 鈴木 康之; 藤野 泰宏; 新関 亮; 安田 武生; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  40-  (7)  1104  -1104  2007/07
• V-1-81 膵癌手術における上腸間膜静脈 : 臍静脈バイパスを用いた門脈合併切除・再建(膵4 膵体尾部切除,一般演題(ビデオ),第62回日本消化器外科学会定期学術総会)

  辻村 敏明; 鈴木 康之; 松本 逸平; 新関 亮; 寺井 祥雄; 藤野 泰宏; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  40-  (7)  1223  -1223  2007/07
• P-2-643 胆道癌転移陽性リンパ節における癌細胞置換率の臨床的意義(胆 化学療法・他,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

  森本 大樹; 味木 徹夫; 藤田 恒憲; 松本 拓; 美田 良保; 新関 亮; 松本 逸平; 藤野 泰宏; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  40-  (7)  1419  -1419  2007/07
• P-1-440 膵癌に対する膵頭十二指腸切除術後,短期間で残膵癌を認め切除した1例(膵 稀な腫瘍2,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

  後藤 直大; 松本 逸平; 藤野 泰宏; 高瀬 至朗; 安田 武生; 新関 亮; 藤田 恒憲; 味木 徹夫; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  40-  (7)  1295  -1295  2007/07
• P-1-417 膵頭部癌を合併した膵体尾部脂肪置換の1例(膵 手術・他,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

  寺井 祥雄; 新関 亮; 松本 逸平; 辻村 敏明; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 藤野 泰宏; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  40-  (7)  1293  -1293  2007/07
• P-2-438 膵頭十二指腸切除術を行った副腎癌膵転移の1例(膵 転移性腫瘍,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

  新関 亮; 松本 逸平; 藤野 泰宏; 外山 博近; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 上田 隆; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  40-  (7)  1393  -1393  2007/07
• marginal dose膵島移植における移植後酸素化Perfluorochemical腹腔内投与の有効性

  酒井 哲也; 李 世日; 谷岡 康喜; 松本 逸平; 後藤 直大; 寺井 祥雄; 加茂田 泰久; 辻村 敏明; 藤野 泰宏; 黒田 嘉和  日本消化器外科学会雑誌  40-  (7)  1205  -1205  2007/07
• 二層法を応用した膵消化法の有用性

  後藤 直大; 谷岡 康喜; 酒井 哲也; 寺井 祥雄; 加茂田 泰久; 李 世日; 辻村 敏明; 松本 逸平; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  42-  (3)  295  -295  2007/06
• 酸素化Perfluorochemical(PFC)腹腔内投与による経門脈的移植膵島の生着改善効果における組織学的検討

  李 世日; 酒井 哲也; 谷岡 康喜; 松本 逸平; 寺井 祥雄; 加茂田 泰久; 後藤 直大; 辻村 敏明; 藤野 泰宏; 黒田 嘉和  移植  42-  (3)  296  -296  2007/06
• 膵提供から見た神戸大学膵島移植の現状と問題点

  大河原 弘達; 谷岡 康喜; 辻村 敏明; 酒井 哲也; 松本 逸平; 後藤 直大; 加茂田 泰久; 寺井 祥雄; 李 世日; 黒田 嘉和  移植  42-  (3)  299  -299  2007/06
• The histological analysis of the engraftment of intraportally-transplanted islets improved by intraperitoneal injection of oxygenated perfluorochemical.

  Tetsuya Sakai; Shiri Li; Yasuki Tanioka; Ippei Matsumoto; Sachio Terai; Yasuhisa Kamoda; Tadahiro Goto; Toshiaki Tsujimura; Yasuhiro Fujino; Yoshikazu Kuroda  AMERICAN JOURNAL OF TRANSPLANTATION  7-  572  -572  2007/05
• 本学における不安定1型糖尿病に対する心停止下膵島移植治療の現状

  辻村 敏明; 谷岡 康喜; 松本 逸平; 酒井 哲也; 寺井 祥雄; 具 英成; 黒田 嘉和  膵臓  22-  (3)  389  -389  2007/05
• Histological features of lymph node metastasis in patients with biliary tract cancer

  Tetsuo Ajiki; Haruki Morimoto; Takashi Ueda; Hidehiro Sawa; Tsunenori Fujita; Ippei Matsumoto; Takeo Yasuda; Yasulurc Fujino; Yonson Ku; Yoshikazu Kuroda; Yoshifumi Takeyama  GASTROENTEROLOGY  132-  (4)  A846  -A846  2007/04
• Gemcitabine treatment for advanced biliary tract cancers

  Tsunenori Fujita; Tetsuo Ajiki; Ippei Matsumoto; Kenro Hirata; Shiro Takase; Takashi Kamigaki; Makoto Shinzeki; Yasuhiro Fujino; Yeshikazu Kuroda; Yonson Ku  GASTROENTEROLOGY  132-  (4)  A202  -A202  2007/04
• 重症急性膵炎における血液凝固線溶系の異常

  中島 高広; 上田 隆; 竹山 宜典; 安田 武生; 新関 亮; 沢 秀博; 松本 逸平; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  膵臓  22-  (2)  110  -116  2007/04
• 術前診断しえた膵lymphoepithelial cystの1例

  加茂田 泰久; 藤野 泰宏; 上田 隆; 安田 武生; 松本 逸平; 外山 博近; 黒田 嘉和  膵臓  22-  (2)  123  -129  2007/04
• 幽門輪温存膵頭十二指腸切除術(PPPD)と亜全胃温存膵頭十二指腸切除術(SSPPD)の術後短期・中期成績の比較検討

  松本 逸平; 鈴木 康之; 藤野 泰宏; 外山 博近; 新関 亮; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 上田 隆; 黒田 嘉和  日本外科学会雑誌  108-  238  -238  2007/03
• DP-172-9 当科における膵全摘症例の検討 : 膵全摘術の安全性と有益性(第107回日本外科学会定期学術集会)

  外山 博近; 藤野 泰宏; 松本 逸平; 上田 隆; 新関 亮; 安田 武生; 味木 徹夫; 藤田 恒憲; 黒田 嘉和  日本外科学会雑誌  108-  (2)  665  -665  2007/03
• PD-10-5 重症急性壊死性膵炎の感染予知におけるLDH/リンパ球数比の有用性(第107回日本外科学会定期学術集会)

  新関 亮; 上田 隆; 安田 武生; 沢 秀博; 中島 高広; 松本 逸平; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 竹山 宜典; 黒田 嘉和  日本外科学会雑誌  108-  (2)  131  -131  2007/03
• 二層法を利用した移植前膵島機能評価法

  後藤 直大; 鈴木 康之; 金城 勝; 酒井 哲也; 谷岡 康喜; 寺井 祥雄; 加茂田 泰久; 外山 博近; 辻村 敏明; 松本 逸平; 藤野 泰宏; 黒田 嘉和  日本外科学会雑誌  108-  (臨増2)  497  -497  2007/03
• Hemosuccus pancreaticusの3自験例 本邦報告75例の検討

  松本 逸平; 安田 武生; 上田 隆; 久津見 弘; 沢 秀博; 三木 生也; 白坂 大輔; 新関 亮; 外山 博近; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 谷岡 康喜; 藤野 泰宏; 黒田 嘉和  日本消化器病学会雑誌  104-  (臨増総会)  A260  -A260  2007/03
• Treatment Outcome of Severe Acute Pancreatitis in Our Department

  YASUDA Takeo; UEDA Takashi; TAKEYAMA Yoshifumi; NAKAJIMA Takahiro; SAWA Hidehiro; SHINZEKI Makoto; MATSUMOTO Ippei; AJIKI Tetsuo; FUJINO Yasuhiro; SUZUKI Yasuyuki; KURODA Yoshikazu  Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine)  27-  (3)  481  -485  2007/03
• 【膵癌化学療法の最前線】浸潤性膵管癌に対するgemcitabineを用いた化学療法の成績

  藤野 泰宏; 松本 逸平; 外山 博近; 高瀬 至郎; 神垣 隆; 上田 隆; 黒田 嘉和  膵臓  22-  (1)  30  -35  2007/02
• Intraperitoneal injection of oxygenated perfluorochemical improves the outcome of intraportal islet transplantation in a rat model

  T. Sakai; S. Li; Y. Tanioka; T. Goto; T. Tanaka; I. Matsumoto; T. Tsujimura; Y. Fujino; Y. Suzuki; Y. Kuroda  TRANSPLANTATION PROCEEDINGS  38-  (10)  3289  -3292  2006/12
• 動脈塞栓術にて救命し得たhemosuccus pancreaticusを呈した胃十二指腸動脈仮性動脈瘤破裂の1例

  松本 逸平; 上田 隆; 味木 徹夫; 安田 武生; 藤田 恒憲; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  日本消化器病学会雑誌  103-  (12)  1397  -1402  2006/12
• 膵頭十二指腸切除/膵全摘術における上腸間膜静脈-臍静脈バイパスを用いた門脈合併切除・再建

  松本 逸平; 鈴木 康之; 藤野 泰宏; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 上田 隆; 谷岡 康喜; 冨永 正寛; 具 英成; 黒田 嘉和  日本臨床外科学会雑誌  67-  (増刊)  293  -293  2006/10
• 膵臓・膵島移植の実際 膵臓保存とviability assayの実際

  谷岡 康喜; 酒井 哲也; 松本 逸平; 辻村 敏明; 後藤 直大; 加茂田 泰久; 李 世日; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  41-  (4)  373  -374  2006/08
• 膵・膵島移植 基礎 酸素化Perfluorochemical(PFC)腹腔内投与による移植膵島生着改善効果

  酒井 哲也; 李 世日; 松本 逸平; 後藤 直大; 加茂田 泰久; 辻村 敏明; 谷岡 康喜; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  41-  (4)  380  -381  2006/08
• 膵島移植 臨床 神戸大学における心停止下摘出膵を用いた膵島移植

  後藤 直大; 谷岡 康喜; 酒井 哲也; 加茂田 泰久; 李 世日; 辻村 敏明; 松本 逸平; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  41-  (4)  382  -382  2006/08
• 提供膵をヘリコプターで搬送し、膵島移植を施行した1例

  寺井 祥雄; 谷岡 康喜; 酒井 哲也; 仲井 照和; 加茂田 泰久; 後藤 直大; 李 世日; 松本 逸平; 辻村 敏明; 藤野 泰宏; 黒田 嘉和  日本組織移植学会雑誌  5-  (1)  29  -29  2006/08
• A CASE OF CHOLECYSTITIS WITH HYPOPLASIA OF MEDIAL SEGMENT OF THE LIVER, CHILAIDITI'S SYNDROME AND SUPRAHEPATIC GALLBLADDER

  OKAZAKI Taro; AJIKI Tetsuo; FUJITA Tsunenori; MATSUMOTO Ippei; SUZUKI Yasuyuki; KURODA Yoshikazu  The journal of the Japanese Practical Surgeon Society  67-  (8)  1868  -1872  2006/08
• 0983 膵管嵌入法で再建した膵頭十二指腸切除術の短期・長期成績(膵頭十二指腸切除1,一般演題,第61回日本消化器外科学会定期学術総会)

  鈴木 康之; 藤野 泰宏; 味木 徹夫; 松本 逸平; 藤田 恒憲; 安田 武生; 上田 隆; 黒田 嘉和  日本消化器外科学会雑誌  39-  (7)  1159  -1159  2006/07
• 0886 胆道癌Gemcitabine化学療法施行例における胆管ステント留置の有用性(胆管癌2,一般演題,第61回日本消化器外科学会定期学術総会)

  美田 良保; 味木 徹夫; 藤田 恒憲; 松本 逸平; 安田 武生; 藤野 泰宏; 鈴木 康之; 白坂 大輔; 久津見 弘; 黒田 嘉和  日本消化器外科学会雑誌  39-  (7)  1147  -1147  2006/07
• 膵切除後再建術の工夫 絶対漏れない吻合を目指して 膵頭十二指腸切除における正常膵に対するCUSAを用いた膵切離と膵管嵌入法による膵空腸吻合

  松本 逸平; 鈴木 康之; 藤野 泰宏; 安田 武生; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 谷岡 康喜; 上田 隆; 黒田 嘉和  日本消化器外科学会雑誌  39-  (7)  995  -995  2006/07
• 当科で経験した膵頭部領域動脈瘤破裂の5例

  後藤 直大; 松本 逸平; 安田 武生; 酒井 哲也; 味木 徹夫; 谷岡 康喜; 上田 隆; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  日本消化器外科学会雑誌  39-  (7)  1153  -1153  2006/07
• 不安定I型糖尿病に対する心停止下膵島移植症例の検討

  辻村 敏明; 谷岡 康喜; 酒井 哲也; 松本 逸平; 後藤 直大; 加茂田 泰久; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  日本消化器外科学会雑誌  39-  (7)  1154  -1154  2006/07
• 2132 重症急性膵炎患者での血清High Mobility Group Box Chromosomal Protein 1 (HMGB1)値(急性膵炎,一般演題,第61回日本消化器外科学会定期学術総会)

  安田 武生; 上田 隆; 中島 高広; 沢 秀博; 松本 逸平; 味木 徹夫; 藤野 泰宏; 鈴木 康之; 竹山 宜典; 黒田 嘉和  日本消化器外科学会雑誌  39-  (7)  1306  -1306  2006/07
• 動脈塞栓術で救命し得たHemosuccus pancreaticusを呈した膵頭部仮性動脈瘤破裂の2例

  松本 逸平; 上田 隆; 沢 秀博; 安田 武生; 藤田 恒憲; 酒井 哲也; 味木 徹夫; 谷岡 康喜; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  膵臓  21-  (3)  216  -216  2006/06
• 二層法を用いた心停止ドナーからの膵島移植の可能性について

  田中 智浩; 谷岡 康喜; 後藤 直大; 李 世日; 吉川 卓郎; 柿木 啓太郎; 松本 逸平; 酒井 哲也; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  41-  (2)  146  -146  2006/04
• 膵島分離におけるLow-pressure controlled injection methodによる収量およびqualityの改善

  李 世日; 酒井 哲也; 後藤 直大; 田中 智浩; 吉川 卓郎; 柿木 啓太郎; 松本 逸平; 谷岡 康喜; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  41-  (2)  147  -147  2006/04
• 当院で経験した若年者ドナー(15歳)からの膵島分離2例

  酒井 哲也; 谷岡 康喜; 松本 逸平; 李 世日; 後藤 直大; 田中 智浩; 吉川 卓郎; 柿木 啓太郎; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  41-  (2)  154  -154  2006/04
• 不安定型1型糖尿病に対し膵島移植を施行した1例

  後藤 直大; 酒井 哲也; 谷岡 康喜; 伊藤 光哲; 加茂田 泰久; 李 世日; 田中 智浩; 吉川 卓郎; 柿木 啓太郎; 松本 逸平; 藤野 泰宏; 鈴木 康之; 寺西 哲也; 大原 毅; 春日 雅人; 内野 泰; 河盛 隆造; 黒田 嘉和  移植  41-  (2)  154  -155  2006/04
• 重症急性膵炎における簡易予後スコア

  上田 隆; 安田 武生; 沢 秀博; 中島 高広; 松本 逸平; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 鈴木 康之; 竹山 宜典; 黒田 嘉和  日本外科学会雑誌  107-  (2)  447  -447  2006/03
• 高齢者重症急性膵炎の検討

  中島 高広; 上田 隆; 安田 武生; 沢 秀博; 松本 逸平; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 鈴木 康之; 竹山 宜典; 黒田 嘉和  日本外科学会雑誌  107-  (2)  448  -448  2006/03
• 臨床膵島移植における移植前膵島機能評価

  松本 逸平; 澤田 俊哉; 中野 昌彦; Liu Baolin; 酒井 哲也; 辻村 敏明; 谷岡 康喜; 藤野 泰宏; 鈴木 康之; 黒田 嘉和; Sutherland David E.R.; Hering Bernhard J.  日本外科学会雑誌  107-  (臨増2)  388  -388  2006/03
• 酸素化PFCを用いた膵消化法の有用性

  谷岡 康喜; 酒井 哲也; 辻村 敏明; 松本 逸平; 加茂田 泰久; 後藤 直大; 李 世日; 田中 智浩; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  日本外科学会雑誌  107-  (臨増2)  388  -388  2006/03
• 原因不明の難治性腹水に対し腹腔鏡が有用であった2例

  川崎 健太郎; 市原 隆夫; 後藤 直大; 土田 忍; 味木 徹夫; 松本 逸平; 藤野 泰宏; 鹿股 直樹; 宮崎 博之; 生田 肇; 黒田 嘉和  Gastroenterological Endoscopy  48-  (2)  198  -203  2006/02
• 重症急性膵炎における感染性合併症対策

  上田 隆; 竹山 宜典; 安田 武生; 沢 秀博; 中島 高広; 松本 逸平; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  消化と吸収  28-  (1)  19  -22  2006/02
• A case report of type IV-A congenital dilatation of bile duct with severe acute pancreatitis

  Ippei Matsumoto; Tetsuo Ajiki; Hidehiro Sawa; Tsunenori Fujita; Takashi Ueda; Yasuhiro Fujino; Yasuyuki Suzuki; Yoshikazu Kuroda  Japanese Journal of Gastroenterological Surgery  39-  (3)  323  -328  2006
• 献腎摘出時における膵島移植のための膵臓摘出 神戸大学における膵島移植

  酒井 哲也; 谷岡 康喜; 大河原 弘達; 加茂田 泰久; 李 世日; 後藤 直大; 田中 智浩; 辻村 敏明; 松本 逸平; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  40-  (6)  549  -549  2005/12
• Successful islet transplantation from a single pancreas harvested from a young, low-BMI, non-heart-beating cadaver

  T Goto; Y Tanioka; T Sakai; Matsumoto, I; K Kakinoki; T Tanaka; S Li; T Yoshikawa; Y Fujino; Y Suzuki; Y Kuroda  TRANSPLANTATION PROCEEDINGS  37-  (8)  3430  -3432  2005/10
• 小腸保存への二層法の応用

  鈴木 康之; 藤野 泰宏; 柿木 啓太郎; 吉川 卓郎; 李 世日; 辻村 敏明; 松本 逸平; 酒井 哲也; 谷岡 康喜; 黒田 嘉和  Organ Biology  12-  (3)  234  -234  2005/10
• 心停止後膵臓・膵島移植の現状と問題点 膵臓の温阻血障害と二層法による軽減効果

  谷岡 康喜; 酒井 哲也; 松本 逸平; 田中 智浩; 後藤 直大; 李 世日; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  40-  (総会臨時)  195  -195  2005/10
• Lower-pressure controlled injection of collagenaseによる膵島分離の改善 one donor one recipient移植を目指して

  酒井 哲也; 谷岡 康喜; 松本 逸平; 後藤 直大; 田中 智浩; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  移植  40-  (総会臨時)  363  -363  2005/10
• 胆石性重症急性膵炎の検討

  中島 高広; 上田 隆; 竹山 宜典; 安田 武生; 松村 直樹; 沢 秀博; 松本 逸平; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  膵臓  20-  (5)  427  -434  2005/10
• 二層法によるmarginal donor膵からの膵島移植の可能性

  谷岡 康喜; 酒井 哲也; 加茂田 泰久; 後藤 直大; 田中 智浩; 李 世日; 辻村 敏明; 松本 逸平; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  低温医学  31-  (3)  58  -59  2005/09
• 不安定1型糖尿病に対し膵島移植を施行した1例

  田中 智浩; 酒井 哲也; 谷岡 康喜; 加茂田 泰久; 李 世日; 後藤 直大; 吉川 卓郎; 柿木 啓太郎; 辻村 敏明; 松本 逸平; 藤野 泰宏; 鈴木 康之; 寺西 哲也; 大原 毅; 春日 雅人; 内野 泰; 河盛 隆造; 黒田 嘉和  日本組織移植学会雑誌  4-  (1)  52  -52  2005/08
• 膵島移植ドナープール拡大に対する神戸大学の取り組み

  酒井 哲也; 谷岡 康喜; 大河原 弘達; 加茂田 泰久; 李 世日; 後藤 直大; 田中 智浩; 辻村 敏明; 松本 逸平; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  日本組織移植学会雑誌  4-  (1)  32  -32  2005/08
• 重症急性膵炎における肺障害合併例の検討(膵臓12, 第60回日本消化器外科学会総会)

  沢 秀博; 上田 隆; 松村 直樹; 中島 高広; 松本 逸平; 藤田 恒憲; 味木 徹夫; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  日本消化器外科学会雑誌  38-  (7)  1086  -1086  2005/07
• Lower-pressure controlled distensionによる分離膵島収量およびqualityの改善

  李 世日; 酒井 哲也; 後藤 直大; 田中 智浩; 松本 逸平; 谷岡 康喜; 藤野 泰宏; 鈴木 康之; 黒田 嘉和  日本消化器外科学会雑誌  38-  (7)  1087  -1087  2005/07
• 膵頭十二指腸切除術後の在院死亡率減少の要因に関する検討

  後藤 直大; 鈴木 康之; 藤野 泰宏; 味木 徹夫; 上田 隆; 松本 逸平; 酒井 哲也; 谷岡 康喜; 黒田 嘉和  日本消化器外科学会雑誌  38-  (7)  1198  -1198  2005/07
• 心停止下若年者ドナーからの膵島分離・移植の経験

  松本 逸平; 加茂田 泰久; 李 世日; 後藤 直大; 田中 智浩; 市川 卓郎; 柿木 啓太郎; 酒井 哲也; 谷岡 康喜; 藤野 泰宏; 鈴木 康之; 寺西 哲也; 大原 毅; 春日 雅人; 黒田 嘉和  膵臓  20-  (3)  319  -319  2005/06
• A CASE OF DOUBLE CYSTIC DUCT

  MATSUMOTO Ippei; AJIKI Tetsuo; SAWA Hidehiro; UEDA Takashi; FUJINO Yasuhiro; KURODA Yoshikazu  The journal of the Japanese Practical Surgeon Society  66-  (5)  1151  -1155  2005/05
• 膵体尾部からの人膵島分離 : 収量からみた生体膵島移植の可能性(第105回日本外科学会定期学術集会)

  松本 逸平; 澤田 俊哉; 中野 昌彦; Liu Baolin; 酒井 哲也; 黒田 嘉和; Sutherland David E. R.; Hering Bernhard J.  日本外科学会雑誌  106-  495  -495  2005/04
• 2層法と膵管保存法の併用による膵島収量の改善効果(第105回日本外科学会定期学術集会)

  澤田 俊哉; 松本 逸平; 中野 昌彦; 酒井 哲也; Ansite Jeffery; Zhang Hui J.; Sutherland David E. R.; 山本 雄造; Hering Bernhard J.  日本外科学会雑誌  106-  495  -495  2005/04
• 近畿における膵島移植の現況およびドナー不足問題について

  大河原 弘達; 酒井 哲也; 松本 逸平; 谷岡 康喜; 藤野 泰宏; 鈴木 康之; 松本 慎一; 増谷 友紀; 中谷 武嗣; 北村 惣一郎; 黒田 嘉和  糖尿病  48-  (4)  273  -273  2005/04
• 小腸移植における二層法保存の虚血再灌流障害軽減効果と粘膜再生促進効果

  吉川 卓郎; 鈴木 康之; 藤野 泰宏; 柿木 啓太郎; 李 世日; 後藤 直大; 田中 智浩; 松本 逸平; 酒井 哲也; 谷岡 康喜; 黒田 嘉和  日本外科学会雑誌  106-  (臨増)  263  -263  2005/04
• 消化器外科：膵・膵島移植

  谷岡 康喜; 鈴木 康之; 酒井 哲也; 松本 逸平; 藤野 泰宏; 黒田 嘉和  神緑会学術雑誌  21-  137  -139  2005
• PPB-2-138 胃への直接浸潤をきたし幽門側胃切除を併施した肝細胞癌の一切除例(肝症例2)

  小林 真一郎; 寺嶋 宏明; 松本 逸平; 岡田 憲章; 和田 道彦; 正井 良和; 宮原 勅治; 橋本 隆; 細谷 亮; 梶原 建熈  日本消化器外科学会雑誌  37-  (7)  1268  -1268  2004/07
• PPB-3-109 Groove領域膵癌の進展形式とその病理組織学的検討(膵診断)

  梶原 正俊; 和田 道彦; 松本 逸平; 小林 裕之; 岡田 憲章; 正井 良和; 宮原 勅治; 橋本 隆; 細谷 亮; 梶原 建照  日本消化器外科学会雑誌  37-  (7)  1336  -1336  2004/07
• Donor age effects insulin secretory function of isolated human islets

  SH Ihm; Matsumoto, I; T Sawada; BL Liu; M Nakano; T Sakai; JD Ansite; HJ Zhang; BJ Hering  DIABETES  53-  A35  -A35  2004/06
• PS-142-2 新しい膵保存法によるラ島収量と機能の改善効果

  澤田 俊哉; 松本 逸平; 中野 昌彦; Ansite Jeffrey; Zhang Hui J.; Sutherland David E.R.; 山本 雄造; Hering Bernhard J.  日本外科学会雑誌  105-  559  -559  2004/03
• SF-025-3 ヒト膵島グラフトの機能改善の試み : Caspase-3 inhibitorを用いて

  中野 昌彦; 松本 逸平; 澤田 俊哉; Zhang Hui; Kirchhof Nicole; Hering Bernhard; Sutherland David; 田中 雅夫; 安波 洋一; 池田 靖洋; 小野 順子  日本外科学会雑誌  105-  214  -214  2004/03
• Graft survival analysis in 20 type 1 diabetic islet allograft recipients

  BJ Hering; R Kandaswamy; J Parkey; K Duderstadt; JD Ansite; HJ Zhang; M Nakano; Matsumoto, I; T Sawada; BL Liu; A Bauer; L Guenther; R Jevne; A Gruessner; JA Bluestone; DER Sutherland  AMERICAN JOURNAL OF TRANSPLANTATION  4-  552  -552  2004
• Caspase-3 inhibitor protects isolated human islet cells from apoptosis resulting in improvement of islet graft functions

  M Nakano; Matsumoto, I; T Sawada; J Ansite; J Oberbroeckling; HJ Zhang; N Kirchhof; J Shearer; DER Sutherland; BJ Hering  AMERICAN JOURNAL OF TRANSPLANTATION  4-  395  -395  2004
• Significant improvement of islet yield from obese donor pancreata for human islet isolation and transplantation

  Matsumoto, I; T Sawada; M Nakano; BL Liu; JD Ansite; HJ Zhang; R Kandaswamy; KER Sutherland; BJ Hering  TRANSPLANTATION  76-  (4)  S57  -S58  2003/08
• Successful single donor islet transplantation in type 1 diabetes

  BJ Hering; R Kandaswamy; JD Ansite; PM Fckman; M Nakano; T Sawada; Matsumoto, I; SH Ihm; HJ Zhang; DW Hunter; DFR Sutherland  TRANSPLANTATION  76-  (4)  S23  -S23  2003/08
• Significant impact of two layer (Perfluorochemical/University of Wisconsin solution (PFC/UW)) method on islet yield and function for short-term preservation of human donor pancreata prior to islet isolation and transplantation

  Matsumoto, I; T Sawada; M Nakano; BL Liu; T Sakai; JD Ansite; HJ Zhang; R Kandaswamy; DER Sutherland; Y Kuroda; RJ Hering  TRANSPLANTATION  76-  (4)  S58  -S58  2003/08
• 二層法膵保存を用いたHuman Islet Isolation

  松本 逸平; Hering Bemhard J; 澤田 俊哉; 中野 昌彦; Baolin Liu; Sutherland David ER; 酒井 哲也; 鈴木 康之; 黒田 嘉和  日本外科学会雑誌  104-  248  -248  2003/04
• Caspase-3 inhibitorの単離ヒト膵島におけるアポトーシス抑制効果の検討

  中野 昌彦; 松本 逸平; 澤田 俊哉; Zhang Hui; Kirchhof Nicole; Sutherland David; Hering Bernhard; 田中 雅夫; 安波 洋一; 池田 靖洋  日本外科学会雑誌  104-  445  -445  2003/04
• ATP content of isolated human islets is a possible predictor of in vivo efficacy posttransplantation

  Matsumoto, I; HJ Zhang; T Sawada; M Nakano; BL Liu; J Ansite; DER Sutherland; BJ Hering  CELL TRANSPLANTATION  12-  (2)  142  -143  2003
• Pancreatic intraductal University of Wisconsin solution injection before pancreas cold storage improves islet yield and function

  T Sawada; Matsumoto, I; M Nakano; N Kirchhof; DER Sutherland; BJ Hering  CELL TRANSPLANTATION  12-  (2)  177  -177  2003
• Predictors of human islet isolation yields

  BL Liu; Matsumoto, I; T Sawada; M Nakano; JD Ansite; HJ Zhang; T Jie; R Kandaswamy; DER Sutherland; BJ Hering  CELL TRANSPLANTATION  12-  (2)  165  -166  2003
• ADM,CDDP,ETP,5-FU併用療法にて完全緩解を得られた進行胃癌の1例 血清SCC上昇に関する一考察

  仁木 敏晴; 松本 逸平; 西崎 朗; 井上 弘樹; 濱野 建一; 前田 哲男; 奥谷 俊夫; 廣畑 成也; 中島 卓利; 安武 晃一; 川口 勝徳; 指方 輝正  癌と化学療法  30-  (1)  117  -120  2003/01
• II-9-3 当科におけるT1食道癌症例の検討(第54回日本食道疾患研究会)

  金田 邦彦; 川口 勝徳; 諸久山 仁; 松本 逸平; 国安 哲夫; 小西 宗治; 中江 史郎; 河村 貴; 寒原 芳裕; 河野 範男; 中谷 正史  日本消化器外科学会雑誌  34-  (2)  168  -168  2001/02
• Clinical study of multiple carcinomas of the colon and rectum

  S. Nakae; K. Kawaguchi; H. Sawa; I. Matsumoto; M. Takamatsu  Japanese Journal of Gastroenterological Surgery  34-  (12)  1718  -1726  2001
• PP373 食道癌術後, 再建胃管に発生した潰瘍病変3例の経験

  金田 邦彦; 川口 勝徳; 譜久山 仁; 松本 逸平; 国安 哲矢; 小西 宗治; 中江 史朗; 河村 貢; 寒原 芳浩; 河野 範男; 中谷 正史  日本消化器外科学会雑誌  33-  (7)  1078  -1078  2000/07
• 大腸癌・胃癌の組織内Thymidylate Synthase(TS)とDihydropyrimidine Dehydrogenase(DPD)活性の検討

  中江 史朗; 国安 哲夫; 川口 勝徳; 譜久山 仁; 松本 逸平; 小西 宗治; 金田 邦彦; 河村 貴; 寒原 芳浩; 河野 範男  日本消化器外科学会雑誌  33-  (7)  897  -897  2000/07
• 小腸保存における2層法の有用性

  岩永 康裕; 鈴木 康之; 酒井 哲也; 藤野 泰宏; 谷岡 康喜; 出合 輝行; 松本 逸平; 黒田 嘉和  移植  35-  (2)  127  -127  2000/04
• 膵動注化学療法の基礎的研究

  光辻 理顕; 鈴木 康之; 出合 輝行; 岩永 康裕; 松本 逸平; 神垣 隆; 藤野 泰宏; 具 英成; 黒田 嘉和  日本外科学会雑誌  101-  (臨増)  397  -397  2000/03
• 648 20℃二層法を用いた短時間膵保存による内皮細胞保護効果

  松本 逸平; 鈴木 康之; 藤野 泰宏; 谷岡 康喜; 出合 輝行; 岩永 康裕; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  32-  (6)  1728  -1728  1999/06
• Prolonged preservation of human pancreas before islet isolation with the two-layer cold storage method

  Y Tanioka; Y Suzuki; T Deai; K Suzuki; Matsumoto, I; Y Iwanaga; M Mitsutsuji; Y Ku; Y Kuroda  TRANSPLANTATION  67-  (9)  S645  -S645  1999/05
• Superiority of mild hypothermic preservation (20 degrees C) for pancreatic graft microvasculature using two-layer storage method

  Matsumoto, I; Y Suzuki; Y Fujino; Y Tanioka; T Deai; Y Iwanaga; M Mitsutsuji; Y Ku; Y Kuroda  TRANSPLANTATION  67-  (7)  S93  -S93  1999/04
• The possibility of islet isolation from pancreas harvested from non-heart beating cadaver

  T Deai; Y Tanioka; Y Suzuki; K Suzuki; Y Fujino; Y Iwanaga; M Mitsutsuji; Matsumoto, I; Y Ku; Y Kuroda  TRANSPLANTATION  67-  (7)  S92  -S92  1999/04
• P-510 二層単純浸漬保存法(二層法)による膵の虚血再灌流障害の防止

  鈴木 康之; 藤野 泰宏; 谷岡 康喜; 出合 輝行; 松本 逸平; 岩永 康裕; 岩崎 武; 富永 正寛; 具 英成; 黒田 嘉和  日本外科学会雑誌  100-  439  -439  1999/02
• P-511 心停止下摘出臓器の利用の可能性 : 二層法の応用

  出合 輝行; 谷岡 康喜; 鈴木 康之; 藤野 泰宏; 岩永 康裕; 光辻 理顕; 松本 逸平; 岩崎 武; 富永 正寛; 具 英成; 黒田 嘉和  日本外科学会雑誌  100-  439  -439  1999/02
• 3 膵島移植における二層法臨床応用の可能性

  出合 輝行; 谷岡 康喜; 鈴木 康之; 藤野 泰宏; 岩永 康裕; 松本 逸平; 岩崎 武; 富永 正寛; 具 英成; 黒田 嘉和  日本消化器外科学会雑誌  32-  (2)  371  -371  1999/02
• 418 切除不能膵癌に対する消化管バイパス術の有用性について

  藤野 泰宏; 鈴木 康之; 神垣 隆; 光辻 理顕; 中路 太門; 谷岡 康喜; 出合 輝行; 松本 逸平; 岩永 康裕; 岩崎 武; 富永 正寛; 竹山 宜典; 具 英成; 山本 正博; 黒田 嘉和  日本消化器外科学会雑誌  32-  (2)  478  -478  1999/02
• 202 温阻血障害膵からの膵島収量に及ぼす二層法の影響(第52回日本消化器外科学会総会)

  出合 輝行; 谷岡 康喜; 鈴木 康之; 松本 逸平; 黒田 嘉和  日本消化器外科学会雑誌  31-  (6)  1441  -1441  1998/06
• 膵島分離前の膵保存 : 二層法の応用

  谷岡 康喜; 黒田 嘉和; 鈴木 康之; 出合 輝行; 松本 逸平  日本外科学会雑誌  99-  263  -263  1998/03
• I-207 二層法による膵島分離前の膵保存

  谷岡 康喜; 黒田 嘉和; 鈴木 康之; 出合 輝行; 松本 逸平  日本消化器外科学会雑誌  31-  (2)  606  -606  1998/02
• 術前急性虫垂炎が疑われたPTP誤嚥による回腸末端穿孔の一例

  松本逸平  兵庫全外科医会誌  131-  19  -21  1997
• STUDIES ON PRIMARY MALIGNANT GASTRIC LYMPHOMA : ANALYSIS OF 15 CASES ACCORDING TO THE GENERAL RULES FOR THE GASTRIC CANCER STUDY (THE 12TH EDITION)

  WADA Tetsunari; ISHIKAWA Yoshio; MATSUMOTO Ippei; MAEKAWA Yoko; WAKITA Kazuyuki; KANBARA Yoshihiro; SAKOTA Yoko; KOHNO Norio; NAKAYA Masashi  日本臨床外科医学会雑誌  57-  (4)  794  -797  1996/04
• 示-40 胃の二次発癌症例の検討(<特集>第46回日本消化器外科学会)

  和田 哲成; 脇田 和幸; 松本 逸平; 野村 英明; 前川 陽子; 河村 貴; 寒原 芳浩; 佐古田 洋子; 河野 範男; 中谷 正史; 石川 羊男  日本消化器外科学会雑誌  28-  (6)  1486  -1486  1995/06

Research Grants & Projects

• A double-blinded RCT for investigating clinical efficacy of AHCC in patients with pancreatic ductal adenocarcinoma

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2020/04 -2023/03 

  Author : 里井 壯平; 永川 裕一; 松本 逸平; 山田 豪; 平野 聡; 上村 健一郎; 山本 智久; 藤井 努; 橋本 大輔

   

  膵癌の周術期に術前・術後に化学（放射線）治療の導入は必須であり、その完遂率が予後に関連する。今回報告者らは、切除可能・境界膵癌に対する機能性食品であるAHCCの有用性を検証する多施設共同第II相二重盲検無作為化比較試験を遂行している。切除性分類・腫瘍局在・施設を層別化因子として、AHCC群115名とプラセボ投与の対照群115名の2年無再発生存率を比較する。2020年8月28日に第１例目の登録があり、3月末日時点で37名の登録があり、順調に登録が進行している。 主要評価項目は無病生存期間（2年生存率; 全登録患者）、栄養評価項目で、副次評価項目は安全性（有害事象）、全生存期間、その他の栄養評価項目、サルコペニア、免疫機能評価、QOLである。 対象症例（主な選択基準）は腺癌又は腺扁平上皮癌と組織学的または細胞学的に確認されている膵臓癌で、膵癌取扱い規約第7版で切除可能(R)または切除境界(BR)の患者。手術を企図した術前治療を行う患者。年齢20歳以上、PSが0-2の患者。原疾患に対する既往治療(放射線療法、化学療法、免疫療法等)を受けていない患者。 治療プロトコールは、AHCC群では登録時よりAHCC 1gを1日3回（3g/日）連日経口摂取する。また術後経口摂取が可能となった段階からAHCCを同量経口摂取する。 両群で術前補助療法はゲムシタビン+S-1療法、またはゲムシタビン+ナブパクリタキセル療法を2コース行うこととする。術後補助療法はS-1療法を4週投薬2週休 薬で4コース行う。対照群はAHCC群と同様の方法でプラセボ薬を服用する。
• Multicenter prospective observational study of the patients who undergo total pancreatectomy

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2018/04 -2023/03 

  Author : 松本 逸平; 亀井 敬子; 竹山 宜典

   

  膵全摘術は膵機能の廃絶を招くため、インスリン注射を必要とする糖尿病と膵酵素欠損により膵外分泌機能不全を呈し、QOL低下を著しく招く術式として理解されてきた。近年の周術期管理の向上により、改善傾向にあるとされるも膵全摘術前術後における長期の前向きQOL調査や栄養指標、膵性糖尿病についての前向き研究による報告はない。本研究は膵全摘予定患者を対象として、術前および術後１年後におけるQOL評価、血糖コントロール状況、脂肪肝発生頻度を明らかにすることを目的とした全国多施設共同前向き研究である。全国71施設以上より286例症例が登録された。集計したデータを用いて、膵全摘患者のQOL調査（近畿大学）、膵全摘後の脂肪肝発生頻度とリスク解析（三重大学）、膵全摘の栄養指標と糖尿病コントロールについての解析（香川大学）の3つの研究を行った。 SF36によるQOL評価では「心の健康」は術前より改善を認めたがその他6項目では増悪していた。膵癌の有無、術前糖尿病の有無では術後QOLに差を認めなかった （論文作成中）。 術後脂肪肝の発生頻度は19.6%と比較的低く、女性、高BMI、術後下痢が術後脂肪肝発生の危険因子であった（J Hepatobiliary Pancreat Sci Online ahead of print, 2021）。 術後血糖コントロールは術後3ヶ月で概ね安定し、HbA1c値は7.0%~8.0%の高値で推移する。栄養指標は術後１ヶ月で最も低下し、3ヶ月で改善以降はほぼ横ばいで推移する。一期的膵全摘術と残膵全摘術の術後推移はほぼ同等であった（Br J Surg 108: e237-e-238, 2021）。 以上の結果により、膵全摘術予定患者への情報提供、膵全摘術術後のより質の高い周術期管理法が可能となる。また、本研究で得られた結果をさらに改善することが、新たな課題として抽出された。
• Establishment of a therapy for type 1 diabetes by islet cell transplantation with mesenchymal stem cells

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2015/03 

  Author : ASARI SADAKI; MATSUMOTO Ippei; GOTO Tadahiro; FUKUMOTO Takumi; KU Yonoson

   

  (1) We demonstrated that mesenchymal stem cells (MSCs) were purified by culturing the sorted C57BL/6-derived bone marrow cells (BMCs) with the PI(-)CD45(-)Ter119(-)Sca-1(+)PDGFR-α(+) markers. (2) We showed that transplantation of C57BL/6-derived BMCs (2 x 10^7) induced stable mixed hematopoietic chimerism without GVHD in prediabetic NOD mice preconditioned with temsilorimus (5mg/kg on -day 7 and -day 1), cyclophosphamide (100mg/kg on -day 4 to -day 1) and 2Gy total body irradiation (on day 0). This immunosuppression is a novel regimen based on the clinical transplantation. We also revealed that the induced hematopoietic chimerism completely prevented insulitis and onset of autoimmune diabetes.
• The effect of prophylactic preoperative endoscopic transpapillary pancreatic stenting on clinically significant pancreatic fistula following distal pancreatectomy

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2011 -2013 

  Author : MATSUMOTO Ippei; SHINZEKI Makoto; TOYAMA Hirochika; ASARI Sadaki; GOTO Tadahiro; HORI Yuichi; KU Yonson

   

  Postoperative pancreatic fistula (PF) causes major morbidity after distal pancreatectomy (DP). The purpose of this prospective study is to determine whether prophylactic preoperative endoscopic transpapillary pancreatic stenting (EPS) reduces PF formation after DP. Fifteen patients underwent DP following EPS. Clinically significant PF (ISGPF [the International Study Group on Pancreatic Fistula] classification Grade B and C) occurred in 4 (26.7%). We decided to terminate the study after internal analysis because our study design required 35 patients with estimated PF rate 10%. Prophylactic preoperative EPS dose not reduce PF after DP.
• Effect of inducing neovascularization on islet transplantation

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2008 -2010 

  Author : TSUJIMURA Toshiaki; MATSUMOTO Ippei; SHINZEKI Makoto; TOYAMA Hirochika; GU Eisei

   

  In the mouse islet transplant model with, neovascularisation around the transplanted islets was confirmed one week after transplant and was completed three weeks after transplant, The neovascularity increased by transplanting endothelial progenitor cells (EPC) jointly. By the pathological analysis using a GFP mouse, EPC remained in three weeks after transplant. Neovascularisation derived from EPC occurred in predominance around transplanted islets. However, by induction of EPC, the glucose tolerance of the diabetes mouse was not improved.
• Establishment of simultaneous islet cell and pancreas transplantation from a splitting single-donor pancreas

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2006 -2010 

  Author : MATSUMOTO Ippei; TSUJIMURA Toshiaki; SHINZEKI Makoto; HORI Yuichi; KURODA Yoshikazu; KU Yonson; TOYAMA Hirochika; TANIOKA Yasuki

   

  We have developed a two-layer pancreas preservation method, which supplies oxygen during preservation, and reported efficacy of its use for pancreas and islet cell transplantation. We apply this concept (oxygenation) to the islet isolation process to obtain more islets. We investigated the efficacy of oxygenation during pancreas digestion process (A), low pressure-controlled injection of collagenase (B) and oxygenation on isolated islets during transportation (C). Islet yield and function were improved in protocol A and B. However, there was no advantage in protocol C.
• The efficary of perioperative treatment with G-CSF in pancreatico duodenectomy

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2007 -2009 

  Author : TOYAMA Hirochika; MATSUMOTO Ippei; SHINZEKI Makoto; KU Yonson

   

  Although pancreaticoduodenectomy is the radical operative procedure for malignant disease of biliary tract and pancreas, it often carries an increased risk of infectious complications. G-CSF (granulocyte colony stimulating factor) which increase the mitotic pool of neutrophils is used in the treatment of immunocompromised host with neutropenia. We investigated the effects of perioperative G-CSF treatment in pancreaticoduodenectomy. Leukocyte and neutrophil counts were increased in G-CSF treated group. However, there was no significant difference in serum levels of inflammatory cytokines (IL-6, TNF-alpha, IL-1-beta), incidence of perioperative complication, and length of the hospital stay between both groups. Our investigation could not show the clinical advantage of perioperative G-CSF treatment in pancreaticoduodenectomy.
• Novel method of supply of oxygen to the intraportally-transplanted islets can improve their engraftmaent

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2006 -2008 

  Author : SAKAI Tetsuya; KURODA Yoshikazu; MATSUMOTO Ippei; TSUJIMURA Toshiaki

   

  膵島移植は膵島を分離あるいは門脈内に移植する際に膵島が著しく障害され、1人の患者様を完治させるのに複数回の移植を必要としている。移植直後の障害として門脈内に移植された膵島の低酸素状態に着眼した。ラットの同系門脈内膵島移植において、移植直後に酸素化したPerfluorochemical(PFC)を腹腔内に投与し、6時間毎、48時間までこれを交換することで門脈内酸素濃度を上昇させ、その結果、移植成績および移植後28日目の糖代謝の改善を明らかにした。

Other link

researchmap

https://researchmap.jp/read0140387