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KAWASAKI Naohito

    Department of Pharmacy　Professor/Assistant Dean
Last Updated :2023/12/05

Researcher Information

Degree

  • (BLANK)

URL

J-Global ID

Research Interests

  • Toxicology   疫学   Environmetal hygine   Water Purification   Surface Modification   Air Pollution   

Research Areas

  • Environmental science/Agricultural science / Environmental load reduction/restoration technology / Water environment
  • Environmental science/Agricultural science / Recycling systems and society
  • Environmental science/Agricultural science / Environmental impact assessment
  • Life sciences / Hygiene and public health (laboratory)

Academic & Professional Experience

  • 2010 - Today  Kindai UniversityFaculty of Pharmacy教授
  • 2007 - 2010  Kindai UniversityFaculty of Pharmacy准教授
  • 2002 - 2007  Kindai UniversityFaculty of Pharmacy講師
  • 1998 - 2002  Kindai UniversityFaculty of Pharmacy助手

Association Memberships

  • 日本口腔ケア学会   JAPAN SOCIETY ON WATER ENVIRONMENT   日本抗加齢医学会   日本健康体力栄養学会   日本公衆衛生学会   日本薬学会   THE JAPANESE SOCIETY OF TOXICOLOGY   

Published Papers

  • Kaito Yamashiro; Renya Ikemoto; Fumihiko Ogata; Shigeharu Tanei; Naohito Kawasaki
    Chemical and Pharmaceutical Bulletin Pharmaceutical Society of Japan 71 (8) 655 - 660 0009-2363 2023/08
  • Reita Kadowaki; Fumihiko Ogata; Aoi Fushiki; Saki Daimyo; Saori Deguchi; Hiroko Otake; Mayumi Nagata; Hiroshi Sasaki; Naohito Kawasaki; Noriaki Nagai
    Journal of pharmaceutical health care and sciences 9 (1) 20 - 20 2023/06 
    BACKGROUND: It is important to design an effective formulation to enhance the skin penetration, and nanotechnologies have been used in dermal and transdermal drug delivery. In this study, we prepared formulations (gels) containing l-menthol and felbinac (FEL) solid nanoparticles (FEL-NP gel) for topical application, and investigated the local and systemic absorption of the prepared FEL-NP gel. METHODS: FEL solid nanoparticles were obtained by bead milling of FEL powder (microparticles), and a topical formulation (FEL-NP gel) consisting of 1.5% FEL solid nanoparticles), 2% carboxypolymethylene, 2% l-menthol, 0.5% methylcellulose, and 5% 2-hydroxypropyl-β-cyclodextrin (w/w %) were prepared. RESULTS: The particle size of FEL nanoparticles was 20-200 nm. The released FEL concentration from FEL-NP gel was significantly higher than that from FEL gel without bead mill treatment (carboxypolymethylene gel in which FEL microparticles (MPs) instead of FEL nanoparticles were incorporated, FEL-MP gel), and FEL was released as nanoparticles from the gel. Moreover, both transdermal penetration and percutaneous absorption of FEL-NP gel were significantly increased compared with those of FEL-MP gel, and the area under the FEL concentration-time curve (AUC) of FEL-NP gels was 1.52- and 1.38-fold of commercially available FEL ointment and FEL-MP gel, respectively. In addition, after 24 h of treatment, the FEL content in rat skin treated with FEL-NP gels was 1.38- and 2.54-fold higher than that when treated with commercially available FEL ointment and FEL-MP gel, respectively. Moreover, the enhanced skin penetration of FEL-NP gels was significantly attenuated by inhibition of energy-dependent endocytosis, such as clathrin-mediated endocytosis. CONCLUSIONS: We successfully prepared a topically applied carboxypolymethylene gel containing FEL nanoparticles. In addition, we observed that the endocytosis pathway was mainly related to the high skin penetration of FEL nanoparticles, and FEL-NP gel application resulted in high local tissue concentration and systemic absorption of FEL. These findings provide useful information for the design of topically applied nanoformulations against inflammation by providing local and systemic effects.
  • Fumihiko Ogata; Yugo Uematsu; Noriaki Nagai; Ibuki Kobata; Ayako Tabuchi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Heliyon 9 (3) e14503  2023/03 
    In this study, waste biomass adsorbents produced from mangosteen shells (MGS) were prepared (denoted as MGS500 and MGS1000). The physical and chemical characteristics, such as scanning electron microscopy, thermogravimetric-differential thermal analysis, specific surface area, pore volumes, surface functional groups, and point of zero charge of the prepared MGS samples were determined, and the adsorption capacity of cadmium ions from aqueous media was assessed. The effects of pH, adsorption time, temperature, and coexistence on adsorption were carefully assessed using an inductively coupled plasma optical emission spectrometer under several experimental conditions. The adsorption capacity decreased in the order, MGS < MGS500 < MGS1000. The optimal pH for cadmium ion removal was 5.0. The amount of cadmium ions adsorbed gradually increased with time, and adsorption equilibrium was achieved within 24 h after adsorption. Additionally, the amount of adsorbed cadmium ions increased with increasing adsorption temperature. To elucidate the adsorption mechanism in detail, the elemental distribution and X-ray photoelectron spectra of the prepared adsorbents were analyzed. Finally, desorption solutions such as HNO3, H2O, and NaOH were used to desorb the absorbed cadmium ions from MGS1000. Under our experimental conditions, the desorption percentage of cadmium ions was approximately 98.8% using HNO3. In conclusion, MGS1000 exhibited a good adsorption capacity of 12.0 mg/g for adsorbing cadmium ions from aqueous media and desorption capacity with HNO3 at 1000 mmol/L.
  • Noriaki Nagai; Fumihiko Ogata; Reita Kadowaki; Saori Deguchi; Hiroko Otake; Yosuke Nakazawa; Mayumi Nagata; Hiroshi Sasaki; Naohito Kawasaki
    Frontiers in bioengineering and biotechnology 11 1167291 - 1167291 2023 
    The permeability of the Biopharmaceutics Classification System (BCS) class III drugs are low, and their oral bioavailability needs to be improved. In this study, we attempted to design oral formulations containing famotidine (FAM) nanoparticles to overcome the limitations of BCS class III drugs. Dispersions containing FAM nanoparticles with a particle size of approximately 50-220 nm were produced by the bead-milling treatment. Moreover, we succeeded in preparing an orally disintegrating tablet containing FAM nanoparticles using the dispersions described above, additives (D-mannitol, polyvinylpyrrolidone, and gum arabic), and freeze-dry treatment (FAM-NP tablet). The FAM-NP tablet was disaggregated 3.5 s after addition to purified water, and the FAM particles in the redispersion of the FAM-NP tablet stored for 3 months were nano-sized (141 ± 6.6 nm). The ex-vivo intestinal penetration and in vivo absorption of FAM in rats applied with the FAM-NP tablet were significantly higher than those in rats applied with the FAM tablet containing microparticles. In addition, enhanced intestinal penetration of the FAM-NP tablet was attenuated by an inhibitor of clathrin-mediated endocytosis. In conclusion, the orally disintegrating tablet containing FAM nanoparticles improved low mucosal permeability and low oral bioavailability and overcame these issues of BCS class III drugs as oral formulations.
  • Hiroko Otake; Yu Mano; Saori Deguchi; Fumihiko Ogata; Naohito Kawasaki; Noriaki Nagai
    Biological & pharmaceutical bulletin 46 (5) 707 - 712 2023 
    Wound-healing deficits of the skin, one of the most common complications in patients with diabetes, delay wound healing, significantly reducing the patient's QOL. Therefore, the topical treatment of wound areas with drug-containing ointments and dressings is important. In this study, we investigated the effect of various ointment bases on skin wound healing in normal and streptozotocin-induced diabetic rats (STZ rats). Three ointment bases were used: white ointment (oil-based), absorbent cream (emulsion-based, w/o), and macrogol ointment (water-based). Skin wound healing in STZ rats was delayed compared with that in normal rats. Each of the three ointment bases was applied to the skin wound area in normal rats, and there was no difference in the therapeutic effect. The therapeutic effect of both white ointment and absorbent cream was higher in the STZ rats group than that in the non-treated group, and delayed wound healing was observed in STZ rats treated with macrogol ointment. In conclusion, skin wound healing in STZ rats is affected by the properties of the ointment base, and it is important to use an ointment base that controls the drying of the wound area in STZ rats. These findings provide information for the selection of ointment bases useful for application to skin wounds in patients with diabetes.
  • Kaito Yamashiro; Naho Yamaguchi; Kazunori Sagawa; Shigeharu Tanei; Fumihiko Ogata; Takehiro Nakamura; Naohito Kawasaki
    PloS one 18 (2) e0281599  2023 
    INTRODUCTION: Masked obesity (MO) is defined as a normal body mass index (BMI) with a high body fat percentage (%BF), and is associated with the onset of lifestyle-related diseases. However, little is known about the current status of MO. Therefore, we investigated the relationship of MO to physical characteristics and lifestyle habits among Japanese university students. METHODS: Between 2011 and 2019, we conducted a survey of 10,168 males and 4,954 females with BMI within the normal range (18.5 ≤ BMI < 25 kg/m2). MO was defined as %BF ≥ 20% in males and %BF ≥ 30% in females. Students completed a questionnaire containing items about lifestyle habits. Systolic and diastolic blood pressures were measured, and hypertension was defined as systolic above 140 mmHg and/or diastolic blood pressure above 90 mmHg. A multivariate logistic regression analysis was performed to evaluate the relationships as follows: the relationship of masked obesity to self-reported lifestyle habits, ideal body image, and anthropometric measures; the relationship between hypertension and body indices. RESULTS: The proportion of students with MO in 2019 was 13.4% in males and 25.8% in females, and the proportion of females increased over time. MO was associated with desire for weight loss (odds ratio, 95% confidence interval: 1.76, 1.53-2.02), intake of five macronutrients (0.79, 0.67-0.93), rice and wheat intakes (1.22, 1.01-1.47), sleep duration of < 7hr (0.85, 0.74-0.98), and exercise habit (0.71, 0.63-0.81) in males; and with balanced diet intake (0.79, 0.64-0.99) and exercise habit (0.65, 0.51-0.82) in females. There was a significant association of MO with hypertension in males (1.29, 1.09-1.53). CONCLUSION: The percentage of female students with MO increased during the study period, and in males, MO may be a risk factor for hypertension. These results suggest that intervention for MO is needed in Japanese university students.
  • Yugo Uematsu; Fumihiko Ogata; Kyohei Nishida; Yuri Mizuno; Masashi Yanae; Manabu Takegami; Takehiro Nakamura; Naohito Kawasaki
    Chemical and Pharmaceutical Bulletin Pharmaceutical Society of Japan 70 (12) 876 - 884 0009-2363 2022/12
  • Fumihiko Ogata; Yugo Uematsu; Noriaki Nagai; Misaki Nakamura; Ayako Tabuchi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Bioresource Technology Reports Elsevier BV 20 101238 - 101238 2589-014X 2022/12
  • Kaito Yamashiro; Yusuke Utaka; Shigeharu Tanei; Fumihiko Ogata; Takehiro Nakamura; Naohito Kawasaki
    Journal of Public Health Springer Science and Business Media LLC 2198-1833 2022/11
  • Noriaki Nagai; Fumihiko Ogata; Saori Deguchi; Aoi Fushiki; Saki Daimyo; Hiroko Otake; Naohito Kawasaki
    Pharmaceutics 14 (11) 2022/11 
    We aimed to investigate which base was suitable for preparing transdermal formulations incorporating tulobuterol (TUL) nanoparticles (30-180 nm) in this study. Three bases (water-soluble, absorptive, and aqueous ionic cream) were selected to prepare the transdermal formulations, and TUL nanoparticles were prepared with a bead-milling treatment. In the drug release study, the TUL release from the water-soluble ointment was higher than that from the other two ointments. Moreover, the addition of l-menthol enhanced TUL nanoparticle release from the ointment, and the rat skin penetration of the TUL water-soluble ointment was also significantly higher than that of the other two ointments. In addition, the drug penetration of the TUL water-soluble ointment with l-menthol sustained zero-order release over 24 h, and the skin permeability of TUL increased with TUL content in the ointment. On the other hand, this penetration was significantly inhibited by treatment with a caveolae-mediated endocytosis inhibitor (nystatin). In conclusion, we found that the water-soluble base incorporating TUL nanoparticles and l-menthol was the best among those assessed in this study. Furthermore, the pathway using caveolae-mediated endocytosis was related to the skin penetration of TUL nanoparticles in the TUL water-soluble ointment with l-menthol. These findings are useful for the design of a transdermal sustained-release formulation based on TUL nanoparticles.
  • Kaito Yamashiro; Mika Jouta; Kouichi Hosomi; Satoshi Yokoyama; Yuu Ozaki; Atsushi Hirata; Fumihiko Ogata; Takehiro Nakamura; Shigeharu Tanei; Naohito Kawasaki
    Scientific Reports Springer Science and Business Media LLC 12 (1) 2022/10 
    Abstract Microscopic colitis (MC) is a chronic inflammatory bowel disease that is characterized by nonbloody watery diarrhea. The epidemiology in Japan differs from that in Europe and the United States, but little information is available from epidemiological surveys of MC in Japan. This study aimed to provide a new hypothesis regarding the factors associated with MC by using the Japanese Adverse Drug Event Report (JADER) database. “Colitis microscopic” (preferred term code: 10056979) cases entered into the JADER database between 2004 and 2021 were analyzed. Of the 246,997 cases in the JADER database, 161 cases were observed to be associated with MC. A Weibull analysis revealed that the median onset duration of MC (interquartile range) was 72.5 (36.0‒125.5) days in lansoprazole users and 116.0 (60.3‒1089.0) days in aspirin users. A multiple logistic regression analysis revealed that MC was significantly associated with the female sex, as well as ages ≥ 60 years and drugs including lansoprazole, aspirin, and nicorandil. A subset analysis revealed that MC was positively associated with obesity in female cases. Our study cannot demonstrate a causal inference between MC and each drug; however, the findings suggest that MC was associated with nicorandil as well as with lansoprazole and aspirin.
  • Thanawat Pattananandecha; Sasithorn Sirilun; Sutasinee Apichai; Teerapat Ouirungroj; Phisit Uirungroj; Fumihiko Ogata; Naohito Kawasaki; Chalermpong Saenjum
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH MDPI 19 (19) 2022/10 
    Chlorhexidine gluconate (CHG) is a cationic disinfectant. The positive charge of CHG molecules binds to phospholipid's negative charge in bacterial cell walls, causing membrane disruption. The in vitro kinetic physical, chemical and biological incompatibilities of nine lubricating gels with 1% w/v CHG were investigated. Five containing anionic thickener, two containing nonionic thickener, and two containing cationic thickener were collected from hospitals in northern Thailand. All the anionic and nonionic lubricating gels significantly reduced (p < 0.05) the CHG amount after 5 min of exposure time from 12.54% to 54.99%, respectively. In contrast, the amount of CHG exposed with cationic lubricating gels was maintained. Antibacterial activity was significantly reduced to a 1.17-4.33 log10 reduction for Staphylococcus aureus ATCC25923 and a 1.07-3.52 log10 reduction for Escherichia coli ATCC25922 after 5 min exposure to all anionic and nonionic lubricating gels. In contrast, the two cationic lubricating gels maintained the antibacterial activity of the CHG solution (5.69 +/- 0.14 and 5.45 +/- 0.17 log10 reduction). The results suggest that anionic and nonionic thickeners in lubricating gel formulations may neutralize the positive charge and reduce the antibacterial activity of CHG, reducing its effectiveness as a disinfectant.
  • Sutasinee Apichai; Nuttharikar Thunyajaroen; Tanyuta Prajongsangsri; Pimchanok Tananchai; Thanawat Pattananandecha; Fumihiko Ogata; Naohito Kawasaki; Kate Grudpan; Chalermpong Saenjum
    Sustainable Chemistry and Pharmacy 29 2022/10 
    A green and sustainable downscaled procedure was developed to perform smartphone-based colorimetric determination of fluoroquinolones in extemporaneous syrup formulations. The procedure functioned by complexing fluoroquinolones with metal ions, the most suited of which is a ferric ion, to produce a colored product in a 96-well plate combined with smartphone detection and image processing. It performs on a microscale with 1 min detection time providing high throughput at 960 samples in triplicate/h/a well plate. Linear calibrations constituted the concentration of fluoroquinolones and the relative intensity of blue, yielding LODs (3.3σ) and LOQs (10σ) for ciprofloxacin, norfloxacin, ofloxacin and levofloxacin at 4.6, 8.3, 9.1 and 10.6 μg/mL and 14.0, 25.1, 27.5 and 32.0 μg/mL, respectively, (where σ served as the standard deviation of the intercept, divided by the slope of the linear calibration graph). The developed procedure was applied to real extemporaneous oral ciprofloxacin syrup samples. The results obtained by the developed procedure agreed with that of a standard method, with no significant differences at a confidence level of 95%. The developed procedure is aimed at real-world applications in assays for quality and stability of the extemporaneous formulations in community and health-promoting hospitals. This promotes health and well-being for individuals of all ages by ensuring that everyone gains access to quality essential healthcare services as well as safe, effective, high-quality and affordable pharmaceuticals.
  • K Yamashiro; K Hosomi; S Yokoyama; F Ogata; T Nakamura; N Kawasaki
    Die Pharmazie 77 (7) 243 - 247 2022/09 
    Proton pump inhibitors (PPIs) are commonly used for the prevention or treatment of gastric ulcers, but they can induce hypomagnesemia. Little is known about the onset duration and risk factors related to patient characteristics of this adverse event in Japanese patients. Therefore, we analyzed the time-to-onset of PPI-induced hypomagnesemia and evaluated the association between hypomagnesemia and PPIs using the Japanese Adverse Drug Event Report (JADER) database. We analyzed hypomagnesemia cases between 2004 and 2021. The time-to-onset analysis was performed using the Weibull distribution, and the adjusted reporting odds ratio (aROR) or 95% confidence interval (95% CI) was calculated using a multiple logistic regression analysis. The analysis database comprised 236,525 cases, with 188 cases associated with hypomagnesemia. The median onset duration (interquartile range) of PPI-induced hypomagnesemia was 99.0 (51.8-285.5 ) days, which is considered the random failure type. The multiple logistic regression analysis revealed that hypomagnesemia is significantly associated with male sex (aROR, 95% CI: 1.66, 1.23-2.25) , age < 60 (1.59, 1.14-2.21) , estimated body-mass index (eBMI) (0.94, 0.91-0.98) , PPIs (1.66, 1.18-2.30) , and the interaction of age (<60)*PPIs (1.58, 1.13-2.19) . However, diuretics were not significantly associated with hypomagnesemia. Our results suggest that serum magnesium levels should be measured regularly regardless of the duration of PPI use, especially in patients with male sex, age < 60, or low BMI. These findings will assist health professionals in the adequate use of PPIs. These findings need to be evaluated by cohort studies and long-term clinical investigations.
  • Sutasinee Apichai; Parichart Kummuntakoon; Thanawat Pattananandecha; Jakaphun Julsrigival; Kasirawat Sawangrat; Fumihiko Ogata; Naohito Kawasaki; Kate Grudpan; Chalermpong Saenjum
    Molecules (Basel, Switzerland) 27 (15) 2022/07 
    A sustainable downscaled procedure using smartphone-based colorimetric determination of manganese (Mn(II)) was developed. This novel Mn(II) determination procedure is proposed using a simple, available microwell-plate platform and a smartphone as a detector. This approach is based on the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by periodate using Mn(II) as a catalyst. The catalytic kinetics of Mn(II) under different conditions was investigated to determine the optimum condition where the different catalytic activities of various concentrations of Mn(II) evince. Under the optimum condition, the bluish-green product of oxidized TMB, proportioned to the concentration of Mn(II), was monitored using a smartphone camera, and the color signals were processed using ImageJ Software. The developed procedure showed great selectivity and sensitivity as linearity ranged from 1.8 × 10-6 to 4.6 × 10-5 M (0.1 to 2.5 μg/mL). The limits of detection and quantitation were 3.6 × 10-6 and 1.1 × 10-5 M (0.2 and 0.6 μg/mL), respectively. The determination of Mn(II) in freshwater samples was demonstrated to assess environmental water quality as an initial model to more easily promote water management according to the United Nations Sustainable Development Goals (UN-SDGs). The intensity of the red could be successfully applied to evaluate Mn(II) in canals and river water with no significant differences compared with the reference method of Inductively Coupled Plasma Optical Emission Spectrometry at a confidence level of 95%.
  • Thanawat Pattananandecha; Sutasinee Apichai; Jakaphun Julsrigival; Fumihiko Ogata; Naohito Kawasaki; Chalermpong Saenjum
    Plants (Basel, Switzerland) 11 (13) 2022/06 
    Caesalpinia sappan L. heartwood was collected from Mae Chaem District, Chiang Mai Province, Thailand. Crude extracts were prepared by Soxhlet's extraction using 50, 60, and 70% of ethanol (EtOH) at 50, 60, and 70 °C, and the brazilin content was measured using reversed-phase high performance liquid chromatography (RP-HPLC). The antibacterial activity against foodborne pathogens and anti-inflammatory aspects were investigated. C. sappan, prepared from 70% EtOH at 70 °C (E70T70), significantly (p < 0.05) exhibited the highest amount of brazilin (7.90 ± 0.50% w/w). All extracts were investigated for anti-inflammatory activity through an inhibition effect on nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production in RAW264.7 mouse macrophage cells. The inhibitory effect on cyclooxygenase-2 (COX-2) production in HT-29 and HCT116 was also studied. All the extracts inhibited NO, iNOS, and COX-2 production induced by combined lipopolysaccharide and interferon-γ, especially E70T70, indicating the highest inhibition effect among other extracts. Additionally, E70T70 was selected to determine the antibacterial activity against foodborne pathogens, including Staphylococcus aureus, Escherichia coli, Salmonella enteritidis, and Vibrio parahaemolyticus. The result showed that 200 µg/mL extract reduced all test pathogens 100% at 24 h. These results suggested the potential of using C. sappan L. extract as a natural preservative in food and a natural active pharmaceutical ingredient.
  • Treethip Sukkho; Chartchai Khanongnuch; Saisamorn Lumyong; Jetsada Ruangsuriya; Thanawat Pattananandecha; Sutasinee Apichai; Fumihiko Ogata; Naohito Kawasaki; Chalermpong Saenjum
    PLANTS-BASEL MDPI 11 (11) 2022/06 
    "People-Forest-Miang" communities are villages located in the cultivated area of Camellia sinensis var. assamica, or Cha Miang, in northern Thailand. Cha Miang forests are a form of agriculture relying on forest-rich bioresources. This study focuses on a survey of the diversity of medicinal plants used by "People-Forest-Miang" communities in Mae Kampong Village, Chiang Mai, Thailand. The results demonstrated that 73 species of medicinal plants were used to prevent and treat various ailments. The highest number of species (30.14%) was used for musculoskeletal system disorders, followed by digestive system disorders (21.92%) and unspecified medicinal disorders (15.07%). The alkaline phosphatase (ALP) is the most widely recognized biochemical marker for osteoblast activity. The ALP activity of ethanol and deionized water extracts of the nine selected medicinal plants used for musculoskeletal system disorders were examined in the MG63 cell line. The results showed that the numerous water extracts, including MKP1, MKP2, MKP5, MKP6, MKP7, MKP8, and MKP9, and the ethanolic extracts-namely, MKP2, MKP3, MKP7, and MKP9-significantly increased ALP activity in the MG-63 cell line. The findings indicate that some medicinal plants may be further studied for active chemicals and developed as natural active pharmaceutical ingredients for osteoprotective products.
  • Treethip Sukkho; Chartchai Khanongnuch; Saisamorn Lumyong; Jetsada Ruangsuriya; Thanawat Pattananandecha; Sutasinee Apichai; Fumihiko Ogata; Naohito Kawasaki; Chalermpong Saenjum
    Plants (Basel, Switzerland) 11 (11) 2022/06 
    "People-Forest-Miang" communities are villages located in the cultivated area of Camellia sinensis var. assamica, or Cha Miang, in northern Thailand. Cha Miang forests are a form of agriculture relying on forest-rich bioresources. This study focuses on a survey of the diversity of medicinal plants used by "People-Forest-Miang" communities in Mae Kampong Village, Chiang Mai, Thailand. The results demonstrated that 73 species of medicinal plants were used to prevent and treat various ailments. The highest number of species (30.14%) was used for musculoskeletal system disorders, followed by digestive system disorders (21.92%) and unspecified medicinal disorders (15.07%). The alkaline phosphatase (ALP) is the most widely recognized biochemical marker for osteoblast activity. The ALP activity of ethanol and deionized water extracts of the nine selected medicinal plants used for musculoskeletal system disorders were examined in the MG63 cell line. The results showed that the numerous water extracts, including MKP1, MKP2, MKP5, MKP6, MKP7, MKP8, and MKP9, and the ethanolic extracts-namely, MKP2, MKP3, MKP7, and MKP9-significantly increased ALP activity in the MG-63 cell line. The findings indicate that some medicinal plants may be further studied for active chemicals and developed as natural active pharmaceutical ingredients for osteoprotective products.
  • Fumihiko Ogata; Noriaki Nagai; Mamiko Funaki; Ayako Tabuchi; Yuhei Kobayashi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Chemical and Pharmaceutical Bulletin 70 (5) 400 - 407 0009-2363 2022/05 
    Coal fly ash (FA) was treated by hydrothermal activation with sodium hydroxide solution at different concentrations to optimize the conversion method. Zeolite of the sodium type is prepared from coal FA by 1, 1.5, and 3 mol/L sodium hydroxide solutions (ZE1, ZE1.5, and ZE3). These adsorbents?morphology, crystal structure, scanning electron microscopy, Fourier transform (FT)-IR spectra, cation exchange capacity (CEC), specific surface area and pore volumes, and pHpzc were determined. An adsorption experiment was performed to evaluate the effects of contact time, pH, temperature, and coexistence. From the results, the values of CEC and specific surface area of prepared samples was in the order ZE3 < ZE1.5 < ZE1. The similar trends were observed in lead ions adsorption. In addition, our obtained data elucidate that the ion exchange with sodium ions in the interlayer ZE1 is one of the adsorption mechanisms of Pb2_ from water layer. Finally, lead ions adsorbed on ZE1 could be desorbed using a hydrochloric acid solution, showing that ZE1 could be reused as a water purification agent.
  • Fumihiko Ogata; Noriaki Nagai; Chihiro Ito; Yuhei Kobayashi; Mizuki Yamaguchi; Ayako Tabuchi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    WATER SCIENCE AND TECHNOLOGY IWA PUBLISHING 85 (10) 2827 - 2839 0273-1223 2022/05 
    To increase the adsorption capability of Hg2+ from aqueous media, we prepared sodium-type fine zeolite grains with various particle sizes (denoted as ZE1, ZE2 and ZE3). The particle sizes of ZE1, ZE2 and ZE3 were 16.363 +/- 0.365, 1.454 +/- 0.357 and 0.607 +/- 0.377 mu m, respectively. Moreover, the CEC, specific surface area and pore volume were in the order ZE1 (42 mmol/g and 23.5 m(2)/g) < ZE2 (72 mmol/g and 67.1 m(2)/g) < ZE3 (135 mmol/g and 176.6 m(2)/g). Subsequently, the Hg2+ adsorption capability was investigated. The performance of tested agents on Hg2+ adsorbed was in the order ZE1 (5.0 mg/g) < ZE2 (9.4 mg/g) < ZE3 (20.2 mg/g). It was concluded that fine crystalline zeolite was important in enhancing the adsorption capability of Hg2+. In addition, the mechanism of adsorption of Hg2+ on the ZE samples was evaluated. Our results suggested that Hg2+ was exchanged with sodium ions in the interlayers of ZE samples with correlation coefficients of 0.966-0.979. Our findings revealed that these ZE samples constitute potential agents for the adsorption of Hg2+ from aqueous media.
  • Fumihiko Ogata; Noriaki Nagai; Mamiko Funaki; Ayako Tabuchi; Yuhei Kobayashi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    CHEMICAL & PHARMACEUTICAL BULLETIN PHARMACEUTICAL SOC JAPAN 70 (5) 400 - 407 0009-2363 2022/05 
    Coal fly ash (FA) was treated by hydrothermal activation with sodium hydroxide solution at different concentrations to optimize the conversion method. Zeolite of the sodium type is prepared from coal FA by 1, 1.5, and 3 mol/L sodium hydroxide solutions (ZE1, ZE1.5, and ZE3). These adsorbents' morphology, crystal structure, scanning electron microscopy, Fourier transform (FT)-IR spectra, cation exchange capacity (CEC), specific surface area and pore volumes, and pH(pz)(e) were determined. An adsorption experiment was performed to evaluate the effects of contact time, pH, temperature, and coexistence. From the results, the values of CEC and specific surface area of prepared samples was in the order ZE3 < ZE1.5 < ZE1. The similar trends were observed in lead ions adsorption. In addition, our obtained data elucidate that the ion exchange with sodium ions in the interlayer ZE1 is one of the adsorption mechanisms of Pb2+ from water layer. Finally, lead ions adsorbed on ZE1 could be desorbed using a hydrochloric acid solution, showing that ZE1 could be reused as a water purification agent.
  • Fumihiko Ogata; Noriaki Nagai; Chihiro Ito; Yuhei Kobayashi; Mizuki Yamaguchi; Ayako Tabuchi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Water science and technology : a journal of the International Association on Water Pollution Research 85 (10) 2827 - 2839 2022/05 
    To increase the adsorption capability of Hg2+ from aqueous media, we prepared sodium-type fine zeolite grains with various particle sizes (denoted as ZE1, ZE2 and ZE3). The particle sizes of ZE1, ZE2 and ZE3 were 16.363 ± 0.365, 1.454 ± 0.357 and 0.607 ± 0.377 μm, respectively. Moreover, the CEC, specific surface area and pore volume were in the order ZE1 (42 mmol/g and 23.5 m2/g) < ZE2 (72 mmol/g and 67.1 m2/g) < ZE3 (135 mmol/g and 176.6 m2/g). Subsequently, the Hg2+ adsorption capability was investigated. The performance of tested agents on Hg2+ adsorbed was in the order ZE1 (5.0 mg/g) < ZE2 (9.4 mg/g) < ZE3 (20.2 mg/g). It was concluded that fine crystalline zeolite was important in enhancing the adsorption capability of Hg2+. In addition, the mechanism of adsorption of Hg2+ on the ZE samples was evaluated. Our results suggested that Hg2+ was exchanged with sodium ions in the interlayers of ZE samples with correlation coefficients of 0.966-0.979. Our findings revealed that these ZE samples constitute potential agents for the adsorption of Hg2+ from aqueous media.
  • Ayako Tabuchi; Fumihiko Ogata; Yugo Uematsu; Megumu Toda; Masashi Otani; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Molecules (Basel, Switzerland) 27 (8) 2022/04 
    We combined a nickel-aluminum-zirconium complex hydroxide (NAZ) with colloidal silica as a binder to prepare a granulated agent for adsorbing heavy metals from aqueous media. Three samples with different particle diameters were prepared to evaluate the effects on the properties: small (NAZ-S), medium (NAZ-M), and large (NAZ-L). We confirmed the granulation of the prepared samples at a binder content of 25%. NAZ-S had the largest specific surface area and number of hydroxyl groups, followed by NAZ-M and then NAZ-L. Regarding the adsorption capacity, NAZ-S adsorbed the most chromium(VI) ions followed by NAZ-M and then NAZ-L. The binding energy of Cr(2p) at 575-577 eV was detected after adsorption, and the effects of the temperature, contact time, and pH on the adsorption of chromium(VI) ions were evaluated. We identified the following adsorption mechanism: ion exchange with sulfate ions in the interlayer region of the NAZ samples. Finally, the chromium(VI) ions adsorbed by the NAZ samples were easily desorbed using a desorption solution. The results showed that NAZ offers great potential for the removal of chromium(VI) ions from aqueous solutions.
  • Ayako Tabuchi; Fumihiko Ogata; Yugo Uematsu; Megumu Toda; Masashi Otani; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Molecules 27 (8) 2022/04 
    We combined a nickel–aluminum–zirconium complex hydroxide (NAZ) with colloidal silica as a binder to prepare a granulated agent for adsorbing heavy metals from aqueous media. Three samples with different particle diameters were prepared to evaluate the effects on the properties: small (NAZ-S), medium (NAZ-M), and large (NAZ-L). We confirmed the granulation of the prepared samples at a binder content of 25%. NAZ-S had the largest specific surface area and number of hydroxyl groups, followed by NAZ-M and then NAZ-L. Regarding the adsorption capacity, NAZ-S adsorbed the most chromium(VI) ions followed by NAZ-M and then NAZ-L. The binding energy of Cr(2p) at 575–577 eV was detected after adsorption, and the effects of the temperature, contact time, and pH on the adsorption of chromium(VI) ions were evaluated. We identified the following adsorption mechanism: ion exchange with sulfate ions in the interlayer region of the NAZ samples. Finally, the chromium(VI) ions adsorbed by the NAZ samples were easily desorbed using a desorption solution. The results showed that NAZ offers great potential for the removal of chromium(VI) ions from aqueous solutions.
  • Ayako Tabuchi; Fumihiko Ogata; Yugo Uematsu; Megumu Toda; Masashi Otani; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    MOLECULES MDPI 27 (8) 2022/04 
    We combined a nickel-aluminum-zirconium complex hydroxide (NAZ) with colloidal silica as a binder to prepare a granulated agent for adsorbing heavy metals from aqueous media. Three samples with different particle diameters were prepared to evaluate the effects on the properties: small (NAZ-S), medium (NAZ-M), and large (NAZ-L). We confirmed the granulation of the prepared samples at a binder content of 25%. NAZ-S had the largest specific surface area and number of hydroxyl groups, followed by NAZ-M and then NAZ-L. Regarding the adsorption capacity, NAZ-S adsorbed the most chromium(VI) ions followed by NAZ-M and then NAZ-L. The binding energy of Cr(2p) at 575-577 eV was detected after adsorption, and the effects of the temperature, contact time, and pH on the adsorption of chromium(VI) ions were evaluated. We identified the following adsorption mechanism: ion exchange with sulfate ions in the interlayer region of the NAZ samples. Finally, the chromium(VI) ions adsorbed by the NAZ samples were easily desorbed using a desorption solution. The results showed that NAZ offers great potential for the removal of chromium(VI) ions from aqueous solutions.
  • Fumihiko Ogata; Saki Kawamoto; Ayako Tabuchi; Megumu Toda; Masashi Otani; Takehiro Nakamura; Naohito Kawasaki
    Sustainability (Switzerland) 14 (6) 2022/03 
    In this study, the adsorption and/or desorption capacity of tungsten ions using nickel– aluminum complex hydroxides was assessed. Nickel–aluminum complex hydroxides at various molar ratios, such as NA11 were prepared, and the adsorption capacity of tungsten ions was evaluated. Precisely, the effect of temperature, contact time, pH, and coexistence on the adsorption of tungsten ions in the water layer was demonstrated. Among the nickel–aluminum complex hydroxides at various molar ratios, the adsorption capacity onto NA11 was the highest of all adsorbents. The sulfate ions in the interlayer of NA11 was exchanged to tungsten ions, that is, the adsorption mechanism was ion exchange under our experimental conditions. Additionally, to elucidate the adsorption mechanism in detail, the elemental distribution and X-ray photoelectron spectroscopy of the NA11 surface were analyzed. Finally, the results indicated that the tungsten ions adsorbed using NA11 could be desorbed (recovered) from NA11 using sodium hydroxide solution. These results serve as useful information regarding the adsorption and recovery of tungsten ions using nickel–aluminum complex hydroxides from aqueous media.
  • 有害事象自発報告データベース(JADER)を用いたプロトンポンプ阻害薬による低マグネシウム血症の有害事象プロファイルの評価
    山城 海渡; 細見 光一; 横山 聡; 緒方 文彦; 中村 武浩; 川崎 直人
    日本薬学会年会要旨集 (公社)日本薬学会 142年会 26F - pm08S 0918-9823 2022/03
  • Fumihiko Ogata; Saki Kawamoto; Ayako Tabuchi; Megumu Toda; Masashi Otani; Takehiro Nakamura; Naohito Kawasaki
    SUSTAINABILITY MDPI 14 (6) 2022/03 
    In this study, the adsorption and/or desorption capacity of tungsten ions using nickel-aluminum complex hydroxides was assessed. Nickel-aluminum complex hydroxides at various molar ratios, such as NA11 were prepared, and the adsorption capacity of tungsten ions was evaluated. Precisely, the effect of temperature, contact time, pH, and coexistence on the adsorption of tungsten ions in the water layer was demonstrated. Among the nickel-aluminum complex hydroxides at various molar ratios, the adsorption capacity onto NA11 was the highest of all adsorbents. The sulfate ions in the interlayer of NA11 was exchanged to tungsten ions, that is, the adsorption mechanism was ion exchange under our experimental conditions. Additionally, to elucidate the adsorption mechanism in detail, the elemental distribution and X-ray photoelectron spectroscopy of the NA11 surface were analyzed. Finally, the results indicated that the tungsten ions adsorbed using NA11 could be desorbed (recovered) from NA11 using sodium hydroxide solution. These results serve as useful information regarding the adsorption and recovery of tungsten ions using nickel-aluminum complex hydroxides from aqueous media.
  • Noriaki Nagai; Fumihiko Ogata; Ayari Ike; Yurisa Shimomae; Hanano Osako; Yosuke Nakazawa; Naoki Yamamoto; Naohito Kawasaki
    Pharmaceutics 14 (2) 2022/02 
    We previously reported that the bioavailability (BA) of irbesartan (IRB), a BSC class II drug, was improved by preparing nanocrystalline suspensions. However, nanocrystalline suspensions have chemical and physical instabilities and must be converted into tablets through drying approaches in order to overcome such instabilities. In this study, we attempted to design a molded tablet based on nanocrystalline IRB suspensions (IRB-NP tablet) and investigated the effects of this IRB-NP tablet on blood pressure (BP) in a stroke-prone spontaneously hypertensive (SHR-SP) rat. The IRB-NP tablet (with a hardness of 42.6 N) was developed by combining various additives (methylcellulose, 2-hydroxypropyl-β-cyclodextrin HPβCD, D-mannitol, polyvinylpyrrolidone, and gum arabic) followed by bead-milling and freeze-drying treatments. The mean particle size in the redispersions of the IRB-NP tablet was approximately 118 nm. The solubility and intestinal absorption of IRB in the IRB-NP tablet were significantly enhanced in comparison with the microcrystalline IRB tablet (IRB-MP tablet), and both solubility and clathrin-dependent endocytosis helped improve the low BA of the IRB. In addition, the BP-reducing effect of the IRB-NP tablet was significantly higher than that of the IRB-MP tablet. These results provide useful information for the preservation of nanocrystalline suspensions of BCS class II drugs, such as IRB.
  • Fumihiko Ogata; Yugo Uematsu; Ayako Tabuchi; Takehiro Nakamura; Naohito Kawasaki
    BPB Reports Pharmaceutical Society of Japan 5 (3) 42 - 44 2022
  • Yugo Uematsu; Masashi Yanae; Manabu Takegami; Fumihiko Ogata; Takehiro Nakamura; Naohito Kawasaki
    BPB Reports Pharmaceutical Society of Japan 5 (3) 33 - 38 2022
  • Kaito Yamashiro; Kazunori Sagawa; Shigeharu Tanei; Fumihiko Ogata; Takehiro Nakamura; Naohito Kawasaki
    BPB Reports Pharmaceutical Society of Japan 5 (6) 140 - 146 2022
  • KAWASAKI Naohito; YAMASHIRO Kaito; OGATA Fumihiko; NAKAMURA Takehiro
    Annual Meeting of the Japanese Society of Toxicology The Japanese Society of Toxicology 49.1 P-131  2022 
    Recently, air pollution due to volatile organic compounds has increased. It is suggested that these diffused chemical substance cause chemical substances allergies. As a result, many people have gotten the sick building syndrome due to aromatic hydrocarbons. The adsorption characterization of aromatic hydrocarbons onto activated carbon was investigated using the flow method. The removal efficiency of aromatic hydrocarbons in the gaseous phase was estimated based on the adsorption kinetic constants and the saturated amount adsorbed of aromatic hydrocarbons on the activated carbon. The saturated amount of benzene and toluene adsorbed was greater than that of xylene adsorbed because the molecular sizes of benzene and toluene are smaller than that of xylene. This result indicated that the aromatic hydrocarbons adsorbed to the pore in activated carbon, because the activated carbon has the hydrophobic surface and pore. Generally speaking, the adsorption rate in gaseous phase depends upon the surface polarity and porosity of adsorbent. The amount adsorbed of aromatic hydrocarbons onto the activated carbon with the elapsed time was measured. The adsorption kinetic constant increased in the order of xylene, toluene, and benzene. Those of the three xylene isomers were similar. These results indicated that the adsorption rate of benzene by the activated carbon was the fastest and the kinetic constant depended upon the different between the boiling point and the melting point and the molecular size of the aromatic hydrocarbons.
  • NAKAMURA Takehiro; FUJIMOTO Tsukine; OGATA Fumihiko; KAWASAKI Naohito
    Annual Meeting of the Japanese Society of Toxicology The Japanese Society of Toxicology 49.1 P-19E  2022 
    Environmental problems related to water pollution are also included in the SDGs as issue to be solved all over the world. Certain regions in India have reported the harmful impacts of arsenic contamination in groundwater and other water supplies on human health. Numerous industries rely on dyes to color our clothing, food, and houses, and even small amounts of dye wastewater can lead to specific types of water pollution. Wastewater regulations are not stringently enforced, thus, resulting in disorganized wastewater treatment, which leads to dye pollution of lakes or rivers. Currently, expensive and highly sophisticated equipment are used to reduce the toxicity of these contaminants, but do not address the problems mentioned above. This study aimed to explore and verify the practical feasibility of a method that involves the use of tea leaves as an adsorbent for easy implementation in terms of treatment costs, application environments, and technologies. Used tea leaves were prepared from the 21 most consumed varieties of tea worldwide. The leaves were used as an adsorbent. For the adsorbates, 1 anionic dye and 4 cationic dyes were used for dyes and 6 toxic metals. Dye and metal concentrations were analyzed. Many tea varieties displayed suitability for adsorption, with high adsorption capacities observed for cationic dyes and 3 metals. The physicochemical characterization and adsorption parameters were examined and practical knowledge for predicting adsorption mechanisms was obtained. This presentation will explain the results of detailed data analyses and describe further experiments for practical application.
  • Ayako Tabuchi; Fumihiko Ogata; Megumu Toda; Masashi Otani; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 70 (9) 624 - 627 2022 
    In this study, we evaluate the desorption or recovery capacity of chromium(VI) ions using desorption solutions containing sodium hydroxide (NaOH) or sodium sulfate (Na2SO4). A complex hydroxide of nickel-aluminum-zirconium (NAZ) was prepared as the adsorbent for the removal of chromium(VI) ions. The results from repeated adsorption/desorption experiments on chromium(VI) ions using NAZ complex hydroxide were evaluated. The desorption percentage of chromium(VI) ions increased with the increase in the concentration of NaOH or Na2SO4 in the desorption solution. The determined optimal concentration of NaOH or Na2SO4 in the desorption solution was 10 mmol/L under the used experimental conditions. After three adsorption-desorption cycles, the recovery percentages of chromium(VI) ions using NaOH and Na2SO4 were 60% (total amounts adsorbed and desorbed were 102 and 61 mg/g, respectively) and 75% (total amounts adsorbed and desorbed were 96 and 72 mg/g, respectively), respectively. Additionally, we confirmed the existence of chromium on the surface of the NAZ complex hydroxide. After three adsorption/desorption cycles, the crystal structure of the NAZ complex hydroxide was maintained. These results indicated the potential of the NAZ complex hydroxide using a desorption solution containing NaOH or Na2SO4 for the recovery of chromium(VI) ions.
  • Fumihiko Ogata; Noriaki Nagai; Mamiko Funaki; Ayako Tabuchi; Yuhei Kobayashi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 70 (5) 400 - 407 2022 
    Coal fly ash (FA) was treated by hydrothermal activation with sodium hydroxide solution at different concentrations to optimize the conversion method. Zeolite of the sodium type is prepared from coal FA by 1, 1.5, and 3 mol/L sodium hydroxide solutions (ZE1, ZE1.5, and ZE3). These adsorbents' morphology, crystal structure, scanning electron microscopy, Fourier transform (FT)-IR spectra, cation exchange capacity (CEC), specific surface area and pore volumes, and pHpzc were determined. An adsorption experiment was performed to evaluate the effects of contact time, pH, temperature, and coexistence. From the results, the values of CEC and specific surface area of prepared samples was in the order ZE3 < ZE1.5 < ZE1. The similar trends were observed in lead ions adsorption. In addition, our obtained data elucidate that the ion exchange with sodium ions in the interlayer ZE1 is one of the adsorption mechanisms of Pb2+ from water layer. Finally, lead ions adsorbed on ZE1 could be desorbed using a hydrochloric acid solution, showing that ZE1 could be reused as a water purification agent.
  • Takehiro Nakamura; Sayuri Mishima; Fumihiko Ogata; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 70 (4) 254 - 260 2022 
    In this study, 21 tea types (six black, four green, three Oolong, two herb, and five medicinal) were used to remove ionic dye from wastewater, as they could be potential adsorbents for several ionic dyes without purification or activated treatment. The majority of the 21 teas could adsorb cationic (MB) and anionic (ORII) dyes, with greater suitability for cationic dyes, as well as BB54 and BR46. Black dye (KBla), a mixture of several dyes, was adsorbed to a high degree. The tea waste treatment resulted in chromaticity reduction of the dye solution and turbidity changes. Dye adsorption was greater at higher temperatures than lower ones, although the effect of temperature was not strong. The adsorptions fit the pseudo-second-order-model; therefore, they involved chemical adsorption. The tea waste had great potential for the adsorption of several types of dyes without purification or activated treatment, although the mechanisms are yet to be determined. Therefore, the physical properties and structural components of each tea type should be analyzed by comparing common or different features of tea types. Taken together, many types of tea that are consumed worldwide can be used for efficient adsorption of ionic dyes by application of the tea waste.
  • K Yamashiro; A Hirata; R Ota; F Ogata; T Nakamura; N Kawasaki
    Die Pharmazie 76 (12) 625 - 628 2021/12 
    Cetuximab causes electrolyte abnormalities, such as hypomagnesemia, hypokalemia, and hypocalcemia. However, little is known about the relationships between the onset of hypomagnesemia, patient background before administration, and time-dependent changes in serum magnesium levels. Therefore, we examined the patient backgrounds that influenced the onset of hypomagnesemia and the time-dependent changes in serum magnesium levels in patients receiving cetuximab. A retrospective study was performed to investigate patients with advanced or recurrent colorectal cancer or head and neck cancer, treated with a cetuximab regimen from 2012 to 2020 at Kindai University Nara Hospital. In total, 52 patients who met the inclusion criteria were enrolled in this study. The serum magnesium level was significantly lower in the hyponatremia before the administration group than in the non-hyponatremia group (p < 0.001). Univariate logistic regression analysis revealed that the baseline serum sodium levels (odds ratio [OR]: 0.741, 95% confidence interval [CI]: 0.588-0.934) and the combination of magnesium oxide tablet (OR: 0.997, 95% CI: 0.995-0.999) were one of the independent factors for hypomagnesemia. These results indicated that hyponatremia before administration may be an indicator of serum magnesium levels after administration of cetuximab. Cetuximab-induced hypomagnesemia may be predicted using baseline serum sodium levels, and hypomagnesemia may be prevented by administration of magnesium oxide tablets. Our findings provided new evidence for the management of serum magnesium levels in patients receiving cetuximab.
  • 快適な住環境のためのおから炭の製造と調湿
    山城 海渡; 緒方 文彦; 中村 武浩; 川崎 直人
    日本公衆衛生学会総会抄録集 日本公衆衛生学会 80回 486 - 486 1347-8060 2021/11
  • Saori Deguchi; Fumihiko Ogata; Masaki Watanabe; Hiroko Otake; Naoki Yamamoto; Naohito Kawasaki; Noriaki Nagai
    Pharmaceutics 13 (9) 2021/09 
    We attempted to design irbesartan nanocrystalline (IRB-NC) suspensions by the bead mill method, and we evaluated the bioavailability (BA) in the oral administration of the nanocrystalline drug. The mean particle size of the IRB-NC suspensions was approximately 140 nm, and the crystalline structure of irbesartan in these suspensions was different using the bead mill method. The aggregation and degradation of irbesartan were not observed for one month, and the solubility increased. Moreover, the inclusion complex formation of IRB-NC suspensions with 2-hydroxypropyl-β-cyclodextrin was higher than that in traditional IRB powder (IRB-P). In addition, the intestinal absorption of IRB-NC suspensions was higher than that of IRB-P suspensions, and the reducing effect on blood pressure in spontaneously hypertensive SHR-SP rats orally administered IRB-NC suspensions was significantly higher than in those administered IRB-P suspensions. On the other hand, the intestinal penetration of IRB-NC suspensions was attenuated by the inhibitors of clathrin-dependent endocytosis (CME). In conclusion, we improved the low oral BA of irbesartan by preparing IRB-NC suspensions and showed that both the solubility and CME are related to the enhanced intestinal absorption of IRB-NC suspensions, resulting in an increase in their antihypertensive effect. These findings provide significant information for the development of oral nanomedicines.
  • Thanawat Pattananandecha; Sutasinee Apichai; Sasithorn Sirilun; Jakaphun Julsrigival; Kasirawat Sawangrat; Fumihiko Ogata; Naohito Kawasaki; Busaban Sirithunyalug; Chalermpong Saenjum
    Molecules (Basel, Switzerland) 26 (17) 2021/08 
    Five glutinous purple rice cultivars and non-glutinous purple rice cultivated in different altitudes in the north of Thailand were collected. The samples were extracted using ethanol and determined for anthocyanins using HPLC. The total phenolic content (TPC), total flavonoid content (TFC), and the antioxidant, anti-inflammatory, and antimicrobial activities against foodborne pathogens were investigated. The highland glutinous cultivar named Khao' Gam Luem-Phua (KGLP) extract had significantly high levels of cyanidin 3-O-glucoside, peonidin 3-O-glucoside, delphinidin 3-O-glucoside, TPC, and TFC, as well as exerting a potent antioxidant activity through ABTS assay (524.26 ± 4.63 VCEAC, mg l-ascorbic-ascorbic/g extract), lipid peroxidation (IC50 = 19.70 ± 0.31 µg/mL), superoxide anions (IC50 = 11.20 ± 0.25 µg/mL), nitric oxide (IC50 = 17.12 ± 0.56 µg/mL), a suppression effect on nitric oxide (IC50 = 18.32 ± 0.82 µg/mL), and an inducible nitric oxide synthase production (IC50 = 23.43 ± 1.21 µg/mL) in combined lipopolysaccharide-interferon-γ-activated RAW 264.7 murine macrophage cells. Additionally, KGLP also exhibited antimicrobial activity against foodborne pathogens, Staphylococcus aureus, Escherichia coli, Salmonella Enteritidis, and Vibrio parahaemolyticus. These results indicate that Thai glutinous purple rice cultivated on the highland could be a potent natural source of antioxidants, anti-inflammatories, and antimicrobial agents for use as a natural active pharmaceutical ingredient in functional food and nutraceutical products.
  • Thanawat Pattananandecha; Sutasinee Apichai; Jakaphun Julsrigival; Malyn Ungsurungsie; Suched Samuhasaneetoo; Pat Chulasiri; Pakakrong Kwankhao; Supaporn Pitiporn; Fumihiko Ogata; Naohito Kawasaki; Chalermpong Saenjum
    Plants (Basel, Switzerland) 10 (8) 2021/08 
    The current study investigated the inhibiting effect on reactive oxygen species (ROS), reactive nitrogen species (RNS), and matrix metalloproteinase-1 (MMP-1) production in a cell-based study of standardized rosmarinic acid enriched extract (SRAEE) prepared from Thunbergia laurifolia leaves. HPLC chromatogram revealed that rosmarinic acid is a major component in prepared SRAEE, followed by caffeic acid. SRAEE exhibited antioxidant activity both in vitro and cell-based studies. SRAEE showed scavenging effects on nitric oxide and superoxide anion and inhibition effects on lipid peroxidation in vitro. SRAEE also inhibited ROS and MMP-1 production in normal human dermal fibroblast cells induced by H2O2 and UVA, respectively, without exerted cytotoxicity. Additionally, collagen degradation was protected by SRAEE induced by UVA. Nitric oxide and inducible nitric oxide synthase (iNOS) productions were also inhibited by SRAEE in RAW264.7 mouse macrophage cells induced by combined lipopolysaccharide (LPS)-interferon-γ (IFN-γ). The results indicated that SRAEE is a potential candidate as a natural pharmaceutical active ingredient for cosmeceutical product application.
  • Eri Nagahashi; Fumihiko Ogata; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Minerals 11 (8) 2021/08 
    The characteristics of acid-activated raw bentonite (RB) activated with binary acid solutions sulfuric acid + nitric acid, nitric acid + phosphoric acid, and phosphoric acid + sulfuric acid, at a concentration of 5 mol/L (denoted as 5-SN, 5-NP, and 5-PS), were evaluated. Moreover, its application for improving the electrical conductivity in tap water was demonstrated. Acid activation induced the partial destruction of RB; subsequently, there was a significant release of sodium ions from the RB. In addition, the specific surface area and pore volume of 5-SN, 5-NP, and 5-PS were higher than those of RB. Next, the electrical conductivity when using RB increased with adsorption treatment because sodium ions were released from the RB. However, the electrical conductivity significantly decreased with adsorption treatment when using acid-activated RB. Specifically, magnesium ions, calcium ions, and potassium ions were removed into 5-SN, 5-NP, and 5-PS, and sodium ions were not released from the RB simultaneously. The removal percentage of the electrical conductivity using 5-SN, 5-NP, and 5-PS was approximately 31% to 36%. The results indicated that employing acid-activated RB with a binary acid solution is a useful method for decreasing the electrical conductivity in tap water.
  • Yugo Uematsu; Fumihiko Ogata; Noriaki Nagai; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Heliyon 7 (7) e07644  2021/07 
    Raw and calcined basil seeds (BS and BS1000, respectively) were evaluated for their ability to remove herbicides such as paraquat and diquat. The physicochemical properties of BS and BS1000 were determined and the effects of contact time and initial concentration on paraquat and diquat adsorption were assessed. After calcination treatment, the number of pores in BS increased, and the specific surface area was increased from 0.265 to 86.902 m2 g-1. The quantity of herbicides adsorbed using BS1000 was greater than that using either BS or medicinal-grade carbon. Additionally, the adsorption quantity increased with the increase in contact time and initial concentration of herbicide. Therefore, BS1000 is a potential resource for the removal of herbicides. Moreover, BS and BS1000 exhibited the capacity for herbicide adsorption in simulated intestinal fluid.
  • Hiroko Otake; Mizuki Yamaguchi; Fumihiko Ogata; Saori Deguchi; Naoki Yamamoto; Hiroshi Sasaki; Naohito Kawasaki; Noriaki Nagai
    International journal of molecular sciences 22 (10) 2021/05 
    We previously designed a Carbopol gel formulation (N-IND/MEN) based on a combination of indomethacin solid nanoparticles (IND-NPs) and l-menthol, and we reported that the N-IND/MEN showed high transdermal penetration. However, the detailed mechanism for transdermal penetration of IND-NPs was not clearly defined. In this study, we investigated whether endocytosis in the skin tissue of rat and Göttingen minipig is related to the transdermal penetration of IND-NPs using pharmacological inhibitors of endocytosis. The pharmacological inhibitors used in this study are as follows: 54 µM nystatin, a caveolae-mediated endocytosis (CavME) inhibitor; 40 µM dynasore, a clathrin-mediated endocytosis (CME) inhibitor; and 2 µM rottlerin, a micropinocytosis (MP) inhibitor. The N-IND/MEN was prepared by a bead mill method, and the particle size of solid indomethacin was 79-216 nm. In both rat and Göttingen minipig skin, skin penetration of approximately 80% IND-NPs was limited by the stratum corneum (SC), although the penetration of SC was improved by the combination of l-menthol. On the other hand, the treatment of nystatin and dynasore decreased the transdermal penetration of indomethacin in rats and Göttingen minipigs treated with N-IND/MEN. Moreover, in addition to nystatin and dynasore, rottlerin attenuated the transdermal penetration of IND-NPs in the Göttingen minipigs' skin. In conclusion, we found that l-menthol enhanced the SC penetration of IND-NPs. In addition, this study suggests that the SC-passed IND-NPs are absorbed into the skin tissue by energy-dependent endocytosis (CavME, CME, and/or MP pathways) on the epidermis under the SC, resulting in an enhancement in transdermal penetration of IND-NPs. These findings provide significant information for the design of nanomedicines in transdermal formulations.
  • Hiroko Otake; Mizuki Yamaguchi; Fumihiko Ogata; Saori Deguchi; Naoki Yamamoto; Hiroshi Sasaki; Naohito Kawasaki; Noriaki Nagai
    Nanomaterials (Basel, Switzerland) 11 (4) 2021/04 
    Cilostazol (CIL) exerted a protective effect by promoting blood-brain barrier integrity as well as improving the status of neurological dysfunctions following cerebral ischemia/reperfusion (I/R) injury. We attempted to design a 0.5% CIL carbopol gel using solid nanoparticles (CIL-Ngel), and then investigated the relationships between energy-dependent endocytosis and the skin penetration of CIL-Ngel in this study. In addition, we evaluated whether the CIL-Ngel attenuated I/R-induced brain injury in a middle cerebral artery occlusion (MCAO)/reperfusion model mouse. The particle size of CIL was decreased using a bead mill, and the CIL particles (14.9 × 1014 particles/0.3 g) in the CIL-Ngel were approximately 50-180 nm. The release of CIL in the CIL-Ngel was higher than that in gel containing CIL powder (CIL-Mgel), and the CIL particles were released from the CIL-Ngel as nanoparticles. In addition, the percutaneous absorption of CIL from the CIL-Ngel was higher in comparison with that from CIL-Mgel, and clathrin-dependent endocytosis and caveolae-dependent endocytosis were related to the enhanced skin penetration of CIL-NPs. In the traditional (oral administration of CIL powder, 3 mg/kg) and transdermal administration (CIL-Ngel, 0.3 g) for 3 days (once a day), the area under the plasma CIL concentration-time curves (AUC) was similar, although the CIL supplied to the blood by the CIL-Ngel was more sustained than that via oral administration of CIL powder. Furthermore, the CIL-Ngel attenuated the ischemic stroke. In conclusion, we designed a gel using solid CIL-NPs, and we showed that the sustained release of CIL by CIL-Ngel provided an effective treatment for ischemic stroke in MCAO/reperfusion model mice. These findings induce the possibilities of developing novel applications of CIL solid nanoparticles.
  • Kaito Yamashiro; Fumihiko Ogata; Takehiro Nakamura; Shigeharu Tanei; Naohito Kawasaki
    Journal of allied health sciences Society of Allied Health Services 12 (1) 16 - 23 2185-0399 2021/04 [Refereed]
  • Yuhei Kobayashi; Fumihiko Ogata; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Sustainability 13 (8) 2021/04 
    The feasibility of using potassium-type zeolite (K-type zeolite) prepared from coal fly ash (CFA) for the removal of Hg2+ from aqueous media and the adsorption/desorption capabilities of various potassium-type zeolites were assessed in this study. Potassium-type zeolite samples were synthesized by hydrothermal treatment of CFA at different intervals (designated CFA, FA1, FA3, FA6, FA12, FA24, and FA48, based on the hours of treatment) using potassium hydroxide solution, and their physicochemical characteristics were evaluated. Additionally, the quantity of Hg2+ adsorbed was in the order CFA, FA1 < FA3 < FA6 < FA12 < FA24 < FA48, in the current experimental design. Therefore, the hydrothermal treatment time is important to enhance the adsorption capability of K-type zeolite. Moreover, the effects of pH, temperature, contact time, and coexistence on the adsorption of Hg2+ were elucidated. In addition, Hg2+ adsorption mechanism using FA48 was demonstrated. Our results indicated that Hg2+ was exchanged with K+ in the interlayer of FA48 (correlation coefficient = 0.946). Finally, adsorbed Hg2+ onto FA48 could be desorbed using a sodium hydroxide solution (desorption percentage was approximately 70%). Our results revealed that FA48 could be a potential adsorbent for the removal of Hg2+ from aqueous media.
  • Saori Deguchi; Fumihiko Ogata; Takumi Isaka; Hiroko Otake; Yosuke Nakazawa; Naohito Kawasaki; Noriaki Nagai
    Pharmaceutics 13 (3) 2021/03 
    Postprandial hyperglycemia, a so-called blood glucose spike, is associated with enhanced risks of diabetes mellitus (DM) and its complications. In this study, we attempted to design nanoparticles (NPs) of protamine zinc insulin (PZI) by the bead mill method, and prepare ophthalmic formulations based on the PZI-NPs with (nPZI/P) or without polyacrylic acid (nPZI). In addition, we investigated whether the instillation of the newly developed nPZI and nPZI/P can prevent postprandial hyperglycemia in a rabbit model involving the oral glucose tolerance test (OGTT). The particle size of PZI was decreased by the bead mill to a range for both nPZI and nPZI/P of 80-550 nm with no observable aggregation for 6 d. Neither nPZI nor nPZI/P caused any noticeable corneal toxicity. The plasma INS levels in rabbits instilled with nPZI were significantly higher than in rabbits instilled with INS suspensions (commercially available formulations, CA-INS), and the plasma INS levels were further enhanced with the amount of polyacrylic acid in the nPZI/P. In addition, the rapid rise in plasma glucose levels in OGTT-treated rabbits was prevented by a single instillation of nPZI/P, which was significantly more effective at attenuating postprandial hyperglycemia (blood glucose spike) in comparison with nPZI. In conclusion, we designed nPZI/P, and show that a single instillation before OGTT attenuates the rapid enhancement of plasma glucose levels. These findings suggest a better management strategy for the postprandial blood glucose spike, which is an important target of DM therapy.
  • セツキシマブ投与患者における血清マグネシウム値に及ぼす影響因子および経時的変化に関する後ろ向き研究
    山城 海渡; 平田 敦士; 太田 涼介; 緒方 文彦; 中村 武浩; 川崎 直人
    日本薬学会年会要旨集 (公社)日本薬学会 141年会 27V11 - pm09S 0918-9823 2021/03
  • Takehiro Nakamura; Tomoki Fujiwara; Fumihiko Ogata; Naohito Kawasaki
    Journal of Environmental Chemical Engineering 9 (1) 2021/02 
    Arsenic is present both in groundwater and wastewater, and arsenic-contaminated water causes environmental pollution and serious health disorders, even at exposure to very low concentrations. Therefore, adsorption methods are attracting interest owing to their simple operation and low cost. It is crucial to develop inexpensive and effective adsorption technologies for removing As(V) from aqueous solutions. In this study, we synthesized novel Mg/Al/Fe (MAF) hydrotalcites at various ratios and evaluated the characteristics of MAF and As(V) ion adsorption capability. Physicochemical properties of MAF were characterized using X-ray diffraction, scanning electron microscopy, or fluoride ion adsorption method, whereas surface binding energy of MAF was measured using an XPS (spectroscopy system by X-ray photoelectron). Adsorption capabilities of MAF were evaluated by examining the effects of various metal adsorbate solution, multiple mixed adsorbate solution, solution pH, and treatment time, and assaying the Langmuir-adsorption and kinetics. MAF had high As(V) adsorption capacity; the amount of As(V) adsorption on MAF-2 was greater than other adsorbents, with selective As(V) adsorption capacity in multiple component solutions. Adsorption isotherm data were fitted using Freundlich and Langmuir models and adsorption dynamics were described by a pseudo-second-order model. A positive linear relationship was observed between the chloride ion eluted from MAF-2 and amount of As(V) ion adsorbed using MAF-2 (r ≥ 0.96). This indicates that the As(V) ion adsorption mechanism involves electrostatic attraction, surface inner-sphere complex formation, and ion exchange between As(V) and hydroxide ions, suggesting that in multiple metal ion mixed liquid phase, MAF-2 is useful for selective and effective adsorption of As(V) ion from arsenic polluted waters.
  • Fumihiko Ogata; Noriaki Nagai; Ayako Tabuchi; Megumu Toda; Masashi Otani; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Water MDPI 13 (4) 2021/02 
    To evaluate the feasibility of nickel-aluminum (the Ni2+:Al3+ molar ratios of 1.0:1.0 and 1.0:2.0 are denoted as NA11 and NA12, respectively) and nickel-aluminum-zirconium type (the Ni2+:Al3+:Zr4+ molar ratios of 0.9:1.0:0.09 and 0.9:2.0:0.09 are denoted as NAZ1 and NAZ2, respectively) hydroxides for Cr(VI) removal from aqueous media, the adsorption capability and adsorption mechanism of Cr(VI) using the above-mentioned adsorbents were investigated in this study. The quantity of Cr(VI) adsorbed onto NA11, NA12, NAZ1, and NAZ2 was 25.5, 25.6, 24.1, and 24.6 mg g(-1), respectively. However, the quantity of aluminum (base metal) released from NA11 (approximately 0.14 mg g(-1)) was higher than that from NAZ1 (approximately 1.0 mu g g(-1)), indicating that NAZ1 was more suitable for Cr(VI) removal than NA11. In addition, the effects of pH, contact time, and temperature on the adsorption of Cr(VI) were evaluated. Moreover, to elucidate the adsorption mechanism of Cr(VI) using NA11 and NAZ1, the elemental distribution, X-ray photoelectron spectrometry spectra, and ion exchange capability were also determined. Cr(VI) adsorbed onto the NAZ1 surface was easily desorbed using a sodium hydroxide solution under our experimental conditions. The information regarding this study can be useful for removing Cr(VI) from aqueous media.
  • Yamashiro Kaito; Hirata Atsushi; Ota Ryosuke; Ogata Fumihiko; Nakamura Takehiro; Kawasaki Naohito
    BPB Reports The Pharmaceutical Society of Japan 4 (1) 22 - 26 2021 

    Cetuximab (Cmab) is known to cause electrolyte abnormalities, including hypomagnesemia, hypokalemia, and hypocalcemia. However, little is known about differences in these electrolyte levels between hypomagnesemia and non-hypomagnesemia group in patients receiving Cmab. Therefore, the aim of this study was to clarify the relationship between these serum electrolyte levels in patients undergoing Cmab therapy. A retrospective study was conducted to investigate patients for advanced or recurrent colorectal cancer and head and neck cancer, treated with a regimen composed of Cmab from 2012 to 2020 at the Kindai University Nara Hospital. A total of 113 patients were identified from the medical records, and 24 patients who met the inclusion criteria were enrolled in this study. In the non-hypomagnesemia group, significant positively correlations were observed between calcium and potassium (p = 0.018), between potassium and magnesium (p = 0.008), and between magnesium and calcium (p = 0.038). Simultaneously, in the hypomagnesemia group, no statistically significant correlations were recorded between these electrolytes. The incidences of hypokalemia, hypomagnesemia, and hypocalcemia were 25.0% (6/24), 29.2% (7/24), and 25.0% (6/24), respectively. Additionally, the onset of hypokalemia was significantly associated with the onset of hypocalcemia (p = 0.009). These data suggest that it is important to monitor these electrolyte levels, especially in patients who received Cmab with combination therapy.

  • Yamashiro Kaito; Hirata Atsushi; Ota Ryosuke; Ogata Fumihiko; Nakamura Takehiro; Kawasaki Naohito
    Fundamental Toxicological Sciences The Japanese Society of Toxicology 8 (5) 147 - 155 2021 

    Liposomal amphotericin B (L-AMB) causes renal dysfunction and hypokalemia, but little is known about the relationship between serum electrolyte levels before or after administration and renal dysfunction. The changes in serum electrolyte levels before and after administration in patients with L-AMB-induced renal dysfunction were examined. This study included 87 patients administered L-AMB at Kindai University Nara Hospital. The number of patients with G1 (serum creatinine (Scr) levels (mg/dL) > 1.07–1.605 in male and > 0.79–1.185 in female) and G2 (Scr level > 1.605–3.21 in male and > 1.185–2.37 in female) was 25 (28.7%) and 14 (16.1%), respectively. Multivariable logistic regression analysis revealed the onset of G2 was significantly associated with baseline estimated glomerular filtration rate (eGFR), odds ratio (OR): 0.99, 95% confidential interval (95% CI): 0.95–1.02 and, baseline serum potassium levels, OR: 3.50, 95% CI: 1.16–12.06. Serum potassium levels were significantly higher in the G2 group than in the G0 group (Scr levels < 1.07 in male and < 0.79 in female) during the study period. These results indicated the changes in serum potassium levels are associated with renal dysfunction. Monitoring of serum potassium levels before and after administration may contribute to the evaluation of renal dysfunction in patients receiving L-AMB.

  • Fumihiko Ogata; Noriaki Nagai; Shouko Iijima; Megumu Toda; Masashi Otani; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 69 (8) 789 - 795 2021 
    In this study, the effect of contact time, temperature, pH, and coexistences on the adsorption of phosphate ions using the complex nickel-aluminum-zirconium hydroxide (NAZ) was evaluated. Moreover, the recovery of adsorbed phosphate ions from NAZ using desorption solution with different concentrations was demonstrated. The results showed that the quantity of phosphate ions adsorbed gradually increased with time, and the adsorption equilibrium was achieved within 24 h after adsorption. This kinetic data could be well described by the pseudo-second-order model with the correlation coefficient in the value of 0.997. Additionally, the quantity of phosphate which was adsorbed increased as temperature increased, and these results corresponded well with both the Langmuir, the correlation coefficient ranged from 0.920-0.949, and Freundlich models, the correlation coefficient ranged from 0.863-0.995. These results showed that the adsorption of phosphate ion was monolayer adsorption onto the NAZ surface. The optimal pH for removal of phosphate ions from aqueous media was during 4-8. In addition, chloride, nitrate, and sulfate ions did not significantly affect to the adsorption capability of phosphate ions in the complex solution system. Finally, the phosphate ions which were adsorbed onto NAZ could be recovered using sodium sulfate solution (recovery percentage: approx. 50% using sodium sulfate solution at 1000 mmol/L). These results highlight the potential of using NAZ as the cost-effectiveness adsorbent for phosphate ions removal from aqueous media.
  • Hiroko Otake; Ryoka Goto; Fumihiko Ogata; Takumi Isaka; Naohito Kawasaki; Shinichiro Kobayakawa; Toru Matsunaga; Noriaki Nagai
    International journal of nanomedicine 16 5343 - 5356 2021 
    Purpose: The multi-instillation of three commercially available (CA) eye drops [fluorometholone (FL)-, bromfenac (BF)- and levofloxacin (LV)-eye drops] has been used to manage pain and inflammation post-intraocular surgery. However, the multi-instillation of these three eye drops causes corneal damage, and the FL drops have the disadvantage of low ocular bioavailability. To overcome these problems, we prepared fixed-combination eye drops based on FL nanoparticles (FL-NPs) and BF/LV solution (nFBL-FC), and evaluated the corneal toxicity and transcorneal penetration of the nFBL-FC eye drops. Methods: FL powder was mixed in 2-hydroxypropyl-β-cyclodextrin solution containing benzalkonium chloride, mannitol and methylcellulose, and milled with a Bead Smash 12 (5500 rpm for 30 s×30 times). The BF/LV solution was then added to the milled-dispersions to be used as nFBL-FC. The FL, BF and LV concentrations were measured by HPLC methods, and transcorneal penetration was evaluated in rabbits. Results: The FL particle size in nFBL-FC was 40-150 nm, with only 0.0018% in liquid form. No aggregation of FL particles in the nFBL-FC was observed for 1 month. The viability of human corneal epithelial cells treated with nFBL-FC was remarkably higher than that of cells subjected to the multi-instillation of the corresponding three CA-eye drops. In addition, the corneal penetrations (AUC) of the FL, BF and LV in nFBL-FC were 4.9-, 1.8-, and 7.1-fold those of the corresponding CA-eye drops, respectively. Moreover, the caveolae-dependent endocytosis (CavME) inhibitor (nystatin) significantly prevented the transcorneal penetration of these drugs. Conclusion: We prepared fixed-combination eye drops based on FL-NPs and BF/LV solution (nFBL-FC), and show that high levels of FL-NPs and dissolved BF/LV (liquid drugs) can be delivered into the aqueous humor by the instillation of nFBL-FC. Further, we show that CavME is mainly related to the enhancement of transcorneal penetration of both the solid (NPs) and liquid drugs.
  • Fumihiko Ogata; Yugo Uematsu; Yuhei Kobayashi; Yuuka Izutani; Chalermpong Saenjum; Megumu Toda; Masashi Otani; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 69 (1) 86 - 91 2021 
    In this study, complex nickel-aluminum hydroxides were prepared at different molar ratios (NA12, NA11, NA21, NA31, and NA41), and their adsorption capability on arsenic ions (As(III)) from aqueous media was assessed. The physicochemical properties such as morphology, X-ray diffraction pattern, specific surface area, numbers of hydroxyl groups, and surface pH were investigated. In addition, the effect of contact time, temperature, and pH on the adsorption capability on As(III) was also evaluated. NA41 exerted the highest adsorption capability on As(III) comparable to other prepared adsorbents. However, the specific surface area and numbers of hydroxyl groups did not significantly affect the adsorption capability on As(III). The equilibrium adsorption of As(III) using NA41 was achieved within 24 h, and the obtained results corresponded to a pseudo-second-order model with correlation coefficient value of 0.980. Additionally, the adsorption isotherms were well described by both the Langmuir and Freundlich equations. The optimal pH condition for removal of As(III) using NA41 was found to be approximately 6-8. Finally, the adsorption mechanism of As(III) was assessed by analyzing the binding energy and elemental distribution, which indicated that the electrostatic interaction and ion exchange influenced the adsorption of As(III) under experimental conditions. These results demonstrated the potential candidate of NA41 as an effective adsorbent on As(III) removal from aqueous media.
  • Eri Nagahashi; Fumihiko Ogata; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 69 (1) 92 - 98 2021 
    This study aimed to investigate the characteristics of acid-activated bentonite by focusing on its capability of improving the quality of tap water used during wire electrical discharge machining. Raw bentonite (RB) was activated using sulfuric acid, nitric acid, and phosphoric acid solutions with concentrations of 1, 5, and 10 mol/L, respectively. Scanning electron microscopy images, specific surface area, pore volume, cation exchange capacity, X-ray diffraction patterns, and binding energy of RB and acid-activated bentonites were also evaluated. The specific surface area and pore volume of acid-activated bentonites exceeded those of RB. Conversely, the cation exchange capacity of acid-activated bentonites exhibited an opposite trend. The electrical conductivity of tap water was decreased significantly due to bentonite activated with sulfuric acid, nitric acid, and phosphoric acid solution (removal percentage of approximately 31-39%), as compared to that due to RB. Therefore, the relationship between electrical conductivity and the removed concentration of anion/cation ions was evaluated; the correlation coefficient was -0.950 for the experimental condition in this study. Additionally, the amount of magnesium, calcium, potassium, and sodium ions were decreased after the treatment. These results indicated that acid-activated bentonite can be produced from RB via acid activation and that it can be used to decrease electrical conductivity of tap water.
  • Fumihiko Ogata; Yuhei Kobayashi; Yugo Uematsu; Titikan Mongkolsiri; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Bioresource Technology Reports 12 2020/12 
    In this study, the application of mangosteen pericarp (MG) as a bio-sorbent based on agricultural waste was assessed for the removal of Hg(II) from aqueous media. The MG was calcined at 500 °C and 1000 °C and was denoted as MG500 and MG1000, respectively. Physicochemical properties were investigated, and the adsorption capability on Hg(II) was assessed. Additionally, the adsorption mechanism on Hg(II) from aqueous media was evaluated via elemental distribution and binding energy analyses. It was observed that the adsorption capability on Hg(II) using MG500 was greater than that of the Hg(II) using MG and MG1000. Additionally, the optimal pH for the removal of Hg(II) from aqueous media using MG500 was approximately 5.0. The intensity of Hg(II) increased after adsorption, and the binding energies of Hg(II) were detected at approximately 100 eV. This result aids in the elucidation of one of the adsorption mechanisms on Hg(II) using MG500.
  • Fumihiko Ogata; Noriaki Nagai; Eri Nagahashi; Natsumi Kadowaki; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    WATER SUPPLY IWA PUBLISHING 20 (7) 2815 - 2825 1606-9749 2020/11 
    In this study, metal complex hydroxide materials containing magnesium to iron in molar ratios of 3:1 and 5:1, referred to in this study as Mg-Fe-CH3.0 and Mg-Fe-CH5.0, respectively, were prepared, and their adsorption capability with respect to fluoride ions was investigated. The physicochemical characteristics of adsorbents were determined using scanning electron microscopy and X-ray diffraction, and specific surface area and the number of hydroxyl groups were calculated. The adsorption behaviors and mechanism of fluoride ions were assessed. The adsorption capability of fluoride ions using Mg-Fe-CH3.0 was greater than that using Mg-Fe-CH5.0. In addition, the amount adsorbed depended on the adsorption temperatures; the adsorption was comparatively less at 5 degrees C than at 25 degrees C. Adsorption mechanism of fluoride ions was evaluated by elemental distribution analysis and binding energy. The binding energy of fluorine onto Mg-Fe-CH3.0 and Mg-Fe-CH5.0 could be detected after adsorption. Additionally, it was clear that one of the adsorption mechanisms was related to the ion exchange between fluoride ions and chloride ions in the interlayer space of the Mg-Fe-CH3.0 and Mg-Fe-CH5.0 (correlation coefficient 0.923-0.965). This study illustrates that both Mg-Fe-CH3.0 and Mg-Fe-CH5.0 have a high potential for fluoride ion adsorption from the aqueous phase.
  • 大学生における血圧と生活習慣との関連性
    山城 海渡; 宇高 勇佑; 緒方 文彦; 中村 武浩; 川崎 直人
    日本公衆衛生学会総会抄録集 日本公衆衛生学会 79回 241 - 241 1347-8060 2020/10
  • 大学生における血圧と生活習慣との関連性
    山城 海渡; 宇高 勇佑; 緒方 文彦; 中村 武浩; 川崎 直人
    日本公衆衛生学会総会抄録集 日本公衆衛生学会 79回 241 - 241 1347-8060 2020/10
  • 水環境保全・改善を指向したカドミウムイオンの除去技術の開発
    緒方 文彦; 永橋 瑛梨; 中村 武浩; 川崎 直人
    日本公衆衛生学会総会抄録集 日本公衆衛生学会 79回 482 - 482 1347-8060 2020/10
  • Fumihiko Ogata; Yugo Uematsu; Mako Fukuda; Chalermpong Saenjum; Mineaki Kabayama; Takehiro Nakamura; Naohito Kawasaki
    JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING ELSEVIER SCI LTD 8 (5) 2020/10 
    In this study, the mechanism of the reaction between phosphate and magnesium hydroxide ions was assessed. In particular, the effect of initial concentration and contact time on the removal of phosphate ions from aqueous media using magnesium hydroxide was demonstrated. The evaluations were conducted after analyses entailing scanning electron microscopy, powder X-ray diffraction, and elemental distribution. The rate of removal of phosphate ions using magnesium hydroxide increased with increase in the initial phosphate ion concentration. Under our experimental conditions, the products after the removal of phosphate ions were magnesium hydroxide, magnesium potassium phosphate hexahydrate, and magnesium hydrogen phosphate trihydrate when the initial concentration was low (5 to 2000 mg/L), medium (from 4000 to 8000 mg/L), and high (15,000 mg/L), respectively. When the initial concentration was 15,000 mg/L, the product changed with elapsed time. Our findings indicated that the crystalline structure changed from that of magnesium potassium phosphate hexahydrate to that of magnesium hydrogen phosphate trihydrate (after 6 h). These results serve as useful information regarding the interaction between phosphate and magnesium ions at high concentrations of phosphate ions in aqueous media.
  • Saori Deguchi; Fumihiko Ogata; Mizuki Yamaguchi; Misa Minami; Hiroko Otake; Kazutaka Kanai; Naohito Kawasaki; Noriaki Nagai
    Cells 9 (10) 2020/09 
    We attempted to design an ophthalmic in situ gel formulation incorporating disulfiram (DIS) nanoparticles (Dis-NPs/ISG) and demonstrated the therapeutic effect of Dis-NPs/ISG on retinal dysfunction in 15-month-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a rat model of diabetes. The DIS particles were crushed using a bead mill to prepare the nanoparticles, and the Dis-NPs/ISG was prepared using a combination of the DIS nanoparticles and an in situ gelling system based on methylcellulose (MC). The particle size of the Dis-NPs/ISG was 80-250 nm, and there was no detectable precipitation or aggregation for 1 month. Moreover, the Dis-NPs/ISG was gelled at 37 °C, and the drug was delivered into the retina by instillation. Only diethyldithiocarbamate (DDC) was detected in the retina (DIS was not detected) when the Dis-NPs/ISG was instilled in the right eye, and the DDC levels in the right retina were significantly higher than those in the left retina. In addition, the retinal residence time of the drug was prolonged by the application of the in situ gelling system, since the DDC levels in the retinas of rats instilled with Dis-NPs/ISG were higher than those in DIS nanoparticles without MC. Furthermore, repetitive instillation of the Dis-NPs/ISG attenuated the deterioration of electroretinograms (ERGs) in 15-month-old OLETF rats by preventing the collapse of ATP production via excessive nitric oxide and recovered the decrease in retinal function. These findings provide important information for the development of novel therapeutic approaches to diabetic retinopathy.
  • 緒方 文彦; 早渕 凌平; Saenjum Chalermpong; 中村 武浩; 川崎 直人
    薬学雑誌 (公社)日本薬学会 140 (9) 1165 - 1173 0031-6903 2020/09 
    シクロデキストリン(CD)およびヒドロキシプロピル基で修飾されたCD(HP-CD)を用いて、水分子との相互作用に関する基礎的検討を行った。水分子の収着・脱着等温線の結果より、HP-CDと水分子との相互作用はヒステリシスになることなく可逆的な反応であることが示唆された。また、CDと水分子のモル数の関係(R値)の評価ではCDをヒドロキシプロピル基で修飾することにより、従来の水酸基の場合と比較して水分子との親和性が向上し、収着能が顕著に改善することが明らかとなり、収着時におけるCDの諸物性変化の検討ではHP-CDと水分子との相互作用には吸着過程が強く関与していることが明らかとなった。さらに、水分子の収着エントロピー及び微分収着熱の結果より、CD及びHP-CD共に水分子との相互作用には水素結合及びファンデルワース力が関与していることが確認できた。
  • 緒方 文彦; 早渕 凌平; Saenjum Chalermpong; 中村 武浩; 川崎 直人
    薬学雑誌 (公社)日本薬学会 140 (9) 1165 - 1173 0031-6903 2020/09
  • 病院内調製した鉄非含有微量元素注射製剤の品質に関する検討
    池西 政幸; 石井 康世; 雪矢 良輔; 緒方 文彦; 川崎 直人; 長井 紀章; 大鳥 徹; 奥野 智之
    Medical Nutritionist of PEN Leaders (有)フジメディカル出版 4 (2) 136 - 140 2432-5678 2020/09 
    中心静脈栄養療法施行中の患者で市販微量元素製剤投与の結果、鉄を除いた製剤の院内調製が必要となった。そこで、他施設の情報(マンガン・亜鉛・銅・ヨウ素/4成分注)を基に調製するも、微量・微小の浮遊物が多いなどの問題が判明したことから、その調製方法を検討し、機器的手法により品質を評価した。すなわち、4成分注を1成分注(銅)と3成分注(マンガン・亜鉛・ヨウ素)の2種類の製剤に分けて調製し、含量試験および微粒子試験を行ったところ、3製剤ともに必要量の微量元素が均一性を維持した状態で調製されていたものの、1成分注と3成分注では、4成分注に比較して微粒子数が減少し、これまでの目視による異物検査の判定に対応した結果が得られた。以上より、4成分配合微量元素製剤を2種類に分ける調製方法は、調製する薬剤師のみならず、投薬する患者においても、より安全で安心かつ適正に提供し、用いることができる改良法の一つであると考える。(著者抄録)
  • Fumihiko Ogata; Sayumi Yasuda; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    E-JOURNAL OF SURFACE SCIENCE AND NANOTECHNOLOGY SURFACE SCI SOC JAPAN 18 269 - 274 1348-0391 2020/09 
    Five kinds of activated carbon (AC1, AC2, AC3, AC4, and AC5) were prepared, and the characteristics (scanning electron microscopy images, specific surface area, pore-volume, pHpzc, surface functional groups, and surface hydroxyl groups) of each activated carbon were investigated. Additionally, the adsorption capability of activated carbons and adsorption mechanisms involved in adsorption of cationic and anionic dyes from the aqueous solution were evaluated. The results suggested that the treatment of activated carbon with silver (AC3), titanium oxide (AC4), or magnetic field (AC5) was not useful for increasing specific surface area and micropore volume. Moreover, the amount of cationic and anionic dyes adsorbed using activated carbon prepared from coconut shells (AC1 and AC2) were higher than that adsorbed using AC3, AC4, and AC5. Subsequently, the adsorption mechanism involved in adsorption of cationic and anionic dyes was also assessed. It was found that the amount of cationic and anionic dyes adsorbed was related to the specific surface area, micropore volume, and acidic or basic functional groups. Finally, the interactions between dyes and AC1 were elucidated in this study. Adsorption of dyes onto the AC1 surface was confirmed by the elemental distribution and X-ray photoelectron spectroscopy analysis. These results provide useful information on the surface interactions between the activated carbon and dyes (high molecular organic compounds).
  • Fumihiko Ogata; Yuuna Kagiyama; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Bioresource Technology Reports 11 2020/09 [Refereed]
     
    © 2020 Elsevier Ltd Herein, we focused on poly-γ-glutamic acid (PG) as a bioresource material for phosphate removal and assessed the efficiency of a combined PG and calcium hydroxide (CH) treatment via elemental distribution and X-ray diffraction analysis. Additionally, this study briefly assessed the applicability of the flocculants obtained from the phosphate removal process as phosphate-based fertilizers. The results showed that phosphate removal capacity was higher when treated with the PG–CH mixture than that with pure PG or CH. Additionally, the phosphate removal treatment with the PG–CH mixture had the advantage of straightforward separation of the supernatant from the flocculant. Moreover, the mechanism of phosphate removal by the PG + CH treatment was evaluated on the basis of elemental distribution and X-ray diffraction analysis. Finally, the flocculants obtained from the PG + CH treatment had 20.5% citric acid-soluble content, indicating their potential as phosphate-based fertilizers.
  • Yuhei Kobayashi; Fumihiko Ogata; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Water 12 (9) 2020/08 [Refereed]
     
    In this study, a novel zeolite (K-type zeolite) was synthesized from coal fly ash (FA), and adsorption capacity on Pb2+ was assessed. Six types of zeolite (FA1, FA3, FA6, FA12, FA24, and FA48) were prepared, and their physicochemical properties, such as surface functional groups, cation exchange capacity, pHpzc, specific surface area, and pore volume, were evaluated. The quantity of Pb2+ adsorbed by the prepared zeolites followed the order FA < FA1 < FA3 < FA6 < FA12 < FA24 < FA48. Current results indicate that the level of Pb2+ adsorbed was strongly related to the surface characteristics of the adsorbent. Additionally, the correlation coefficient between the amounts of Pb2+ adsorbed and K+ released from FA48 was 0.958. Thus, ion exchange with K+ in the interlayer of FA48 is critical for the removal of Pb2+ from aqueous media. The new binding energies of Pb(4f) at 135 and 140 eV were detected after adsorption. Moreover, FA48 showed selectivity for Pb2+ adsorption in binary solution systems containing cations. The results revealed that FA48 could be useful for removing Pb2+ from aqueous media.
  • Fumihiko Ogata; Noriaki Nagai; Megumu Toda; Masashi Otani; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Water 12 (6) 2020/06 [Refereed]
     
    © 2020 by the authors. The technology of wastewater treatment involving removal of heavy metals using complex metal hydroxides is reported. In this study, complex nickel-aluminum (NA11 and NA12) and nickel-aluminum-zirconium (NAZ1 and NAZ2) hydroxides were prepared for the removal of arsenite ions, As(III), from aqueous solution. The characteristics of each adsorbent were evaluated, and the adsorption capacity and adsorption mechanism were determined. The adsorption capacity of As(III) on NAZ1 (15.3 mg g-1) was greater than that on NA11 (9.3 mg g-1). Coverage is directly related to the specific surface area with a correlation coefficient of 0.921. Ion exchange involving sulfate ions in the interlayer of the adsorbent also plays a role in the mechanism of As(III) adsorption as demonstrated by correlation coefficients of 0.797 and 0.944 for the NA11 and NAZ1, respectively. The results demonstrate the usefulness of NAZ1 in removing As(III) from aqueous media.
  • Fumihiko Ogata; Eri Nagahashi; Hirona Miki; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Heliyon 6 (6) e04298  2405-8440 2020/06 [Refereed]
     
    Herein, to assess the adsorption capability and elucidate the adsorption mechanism of Cd(II) from the aqueous phase, virgin lignin (Lig) and calcined lignin (Lig200, Lig400, Lig600, Lig800, and Lig1000) were prepared. The characteristics, including specific surface area and pore volume of adsorbents, were investigated, and the adsorption capability along with the effect of temperature, contact time, and pH on the adsorption of Cd(II) were evaluated. The characteristics of the adsorbent surface were related to the adsorption capability of Cd(II) from the aqueous phase, and the correlation coefficients between the adsorbed amount and specific surface area and total pore volumes were 0.872 and 0.960, respectively. Moreover, the amount adsorbed using Lig800 (91.3 mg/g) was higher than that using other adsorbent samples. The adsorption mechanism was elucidated to investigate the binding energy and elemental distribution before and after Cd(II) adsorption. Finally, the desorption capability of Cd(II) from Lig800 using a hydrochloric acid solution was demonstrated. Results obtained herein suggest that Lig800 is a potential candidate for the removal of Cd(II).
  • Yuhei Kobayashi; Fumihiko Ogata; Takehiro Nakamura; Naohito Kawasaki
    Journal of Environmental Chemical Engineering 8 (2) 2020/04 
    In this study, zeolites (FA6, FA12, and FA24) were prepared from JIS Type-II fly ash (FA) by alkaline hydrothermal treatment, and their physicochemical characteristics were investigated. In addition, their adsorption capability for heavy metals ions (Hg2+ and Pb2+) was evaluated. Zeolites have Hydrosodalite and/or Zeolite P structure, and the specific surface area of FA24 was greater than that of FA6 and FA12. A higher amount of heavy metals ions was adsorbed by FA24 than by FA6 and fA12. After adsorption using FA24, the binding energy of Pb2+ was detected, on the other hand, the binding energy of Hg2+ was not detected under our experimental conditions. These results suggest that FA24 surface properties shows a low adsorption capability of Hg2+. In addition, ion exchange with sodium ions in the adsorbent was also related to the adsorption capability of heavy metals ions (correlation coefficient: 0.965-0.973). A pH of approximately 5 was found to be optimal for the adsorption of heavy metals ions under our experimental conditions.
  • Yugo Uematsu; Fumihiko Ogata; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Sustainability 12 (7) 2020/04 [Refereed]
     
    © 2020 by the authors. To confirm the capability and mechanisms of Sr(II) and Cs(I) adsorption from the aqueous phase using basil seed (BS), virgin BS, calcined BS (BS500 and BS1000), and enzymatically treated BS, namely Mannanase BGM (M-BS), Pectinase G (P-BS), Hemicellulase (H-BS), and Cellulase A (C-BS) was evaluated. The adsorption capabilities of Sr(II) and Cs(I) of various BS adsorbents were also evaluated. The quantity of Sr(II) and Cs(I) adsorbed onto BS was greater than that of BS500 or BS1000, suggesting that the physicochemical characteristics of the BS surface affected Sr(II) and Cs(I) removal from the aqueous phase. Furthermore, the quantity of Sr(II) and Cs(I) adsorbed onto virgin BS was greater than that of enzymatically treated BS, indicating that glucomannan or (1,4)-xylan in the cellulosic hydrocolloid of the BS strongly affected the adsorption capability of Cs(I) or Sr(II) (except for M-BS in Sr(II) adsorption). Our obtained results indicate that, as an adsorbent, BS was capable of removing Sr(II) and Cs(I) from the aqueous solution.
  • Noriaki Nagai; Fumihiko Ogata; Hiroko Otake; Naohito Kawasaki
    Pharmaceutics 12 (4) 2020/04 [Refereed]
     
    Meloxicam (MLX) is widely applied as a therapy for rheumatoid arthritis (RA); however, it takes far too long to reach its peak plasma concentration for a quick onset effect, and gastrointestinal toxicity has been observed in RA patients taking it. To solve these problems, we designed MLX solid nanoparticles (MLX-NPs) by the bead mill method and used them to prepare new oral formulations. The particle size of the MLX-NPs was approximately 20-180 nm, and they remained in the nano-size range for 1 month. The tmax of MLX-NPs was shorter than that of traditional MLX dispersions (MLX-TDs), and the intestinal penetration of MLX-NPs was significantly higher in comparison with MLX-TDs (P < 0.05). Caveolae-dependent endocytosis (CavME), clathrin-dependent endocytosis (CME), and micropinocytosis (MP) were found to be related to the high intestinal penetration of MLX-NPs. The area under the plasma MLX concentration-time curve (AUC) for MLX-NPs was 5-fold higher than that for MLX-TDs (P < 0.05), and the AUC in rats administered 0.05 mg/kg MLX-NPs were similar to rats administered the therapeutic dose of 0.2 mg/kg MLX-TDs. In addition, the anti-inflammatory effect of the MLX-NPs was also significantly higher than that of MLX-TDs at the corresponding dose (P < 0.05), and the therapeutic effect of 0.2 mg/kg MLX-TDs and 0.05 mg/kg MLX-NPs in adjuvant-induced arthritis (AA) rats showed no difference. Furthermore, the gastrointestinal lesions in AA rats treated repetitively with 0.05 mg/kg MLX-NPs were fewer than in rats receiving 0.2 mg/kg MLX-TDs (P < 0.05). In conclusion, we demonstrate that MLX solid nanoparticles allow a quick onset of therapeutic effect and that three endocytosis pathways, CavME, CME, and MP, are related to the high absorption of solid nanoparticles. In addition, we found that MLX solid nanoparticles make it possible to reduce the amount of orally administered drugs, and treatment with low doses of MLX-NPs allows RA therapy without intestinal ulcerogenic responses to MLX. These findings are useful for designing therapies for RA patients.
  • Fumihiko Ogata; Noriaki Nagai; Ryo Itami; Takehiro Nakamura; Naohito Kawasaki
    JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING ELSEVIER SCI LTD 8 (2) 2213-2929 2020/04 [Refereed]
     
    Virgin wheat bran (WB) and calcined wheat bran were prepared at 500 or 1000 degrees C (WB500 or WB1000, respectively), and their physicochemical properties (such as morphological, thermal, specific surface area, point of zero charge pH, and surface functional groups) were investigated to assess their chromium(VI) ion adsorption capability. The amount of chromium(VI) ion adsorbed was in the order WB < WB500 < WB1000. These results showed that the chromium(VI) ion adsorption was related to the WB surface characteristics. Additionally, the amount of chromium (Cr) and oxygen (O) on the WB1000 surface increased after adsorption, which indicated chromium(VI) ions were adsorbed onto the WB1000 surface. Adsorption isotherm and adsorption kinetic data fit the Freundlich (0.879-0.991) and pseudo-second-order models (0.979-0.997), respectively. The optimal pH condition for the removal of chromium(VI) ion from aqueous solution was approximately 2. Finally, WB1000 could be useful for repetition of chromium(VI) ion adsorption/desorption using sodium hydroxide at 1000 mmol/L (at least five times). It was shown that WB1000 has the potential for adsorption and recovery of chromium(VI) ion from aqueous solution using sodium hydroxide.
  • テキストマイニングによる薬学基礎科目の理解につなげる参加型学修システムの分析
    大内 秀一; 松野 純男; 和田 哲幸; 伊藤 栄次; 前川 智弘; 多賀 淳; 細見 光一; 大鳥 徹; 仲西 功; 川崎 直人; 岩城 正宏
    日本薬学会年会要旨集 (公社)日本薬学会 140年会 28P - pm233 0918-9823 2020/03
  • ミネラルウォーターにおけるミネラル量の測定とその特徴を用いた歯科の健康保持
    小林 悠平; 嗣江 建栄; 楊 文彦; 緒方 文彦; 川崎 直人
    日本薬学会年会要旨集 (公社)日本薬学会 140年会 26P - am148S 0918-9823 2020/03
  • 疾病の予測のための爪中ミネラル濃度のモニタリング
    山城 海渡; 浦尾 篤司; 重森 裕之; 堀越 勝博; 緒方 文彦; 中村 武浩; 川崎 直人
    日本薬学会年会要旨集 (公社)日本薬学会 140年会 28Q - am127S 0918-9823 2020/03
  • テキストマイニングによる薬学基礎科目の理解につなげる参加型学修システムの分析
    大内 秀一; 松野 純男; 和田 哲幸; 伊藤 栄次; 前川 智弘; 多賀 淳; 細見 光一; 大鳥 徹; 仲西 功; 川崎 直人; 岩城 正宏
    日本薬学会年会要旨集 (公社)日本薬学会 140年会 28P - pm233 0918-9823 2020/03
  • Noriaki Nagai; Miyu Ishii; Ryotaro Seiriki; Fumihiko Ogata; Hiroko Otake; Yosuke Nakazawa; Norio Okamoto; Kazutaka Kanai; Naohito Kawasaki
    Pharmaceutics 12 (2) 2020/02 [Refereed]
     
    The commercially available rebamipide ophthalmic suspension (CA-REB) was approved for clinical use in patients with dry eye; however, the residence time on the ocular surface for the traditional formulations is short, since the drug is removed from the ocular surface through the nasolacrimal duct. In this study, we designed a novel sustained-release drug delivery system (DDS) for dry eye therapy by rebamipide nanoparticles. The rebamipide solid nanoparticle-based ophthalmic formulation (REB-NPs) was prepared by a bead mill using additives (2-hydroxypropyl-β-cyclodextrin and methylcellulose) and a gel base (carbopol). The rebamipide particles formed are ellipsoid, with a particle size in the range of 40-200 nm. The rebamipide in the REB-NPs applied to eyelids was delivered into the lacrimal fluid through the meibomian glands, and sustained drug release was observed in comparison with CA-REB. Moreover, the REB-NPs increased the mucin levels in the lacrimal fluid and healed tear film breakup levels in an N-acetylcysteine-treated rabbit model. The information about this novel DDS route and creation of a nano-formulation can be used to design further studies aimed at therapy for dry eye.
  • Fumihiko Ogata; Noriaki Nagai; Akane Soeda; Kaito Yamashiro; Takehiro Nakamura; Chalermpong Saenjum; Naohito Kawasaki
    Bioresource Technology Reports 9 2020/02 [Refereed]
     
    © 2020 Elsevier Ltd Disposed human hair was treated with different concentrations of ethylenediamine-N,N,N′,N′-tetraacetic acid (EDTA) (10%, 25%, and 50% denoted as ED10, ED25, and ED50, respectively), and its Sr(II) adsorption capacity from the aqueous phase was evaluated. The amount of Sr(II) adsorbed onto ED25 was 17 mg/g. The amount of Sr(II) adsorbed using ED25 depended on the solution pH, and the optimal pH condition was approximately 4 in our experiment. Because the point of zero charge of human hair is approximately 3.67 to 3.70, electrostatic interaction between Sr(II) and human hair easily occurred. Finally, the Sr(II) adsorbed onto ED25 was easily desorbed using a sodium hydroxide solution at a pH of 3 (desorption percentage of 95.4%). EDTA treatment of human hair was useful for producing a novelty adsorbent to adsorb Sr(II) from aqueous solution. These results can be applied to the solution of problems regarding the water environment and waste materials.
  • Fumihiko Ogata; Sayumi Yasuda; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    e-Journal of Surface Science and Nanotechnology 18 269 - 274 2020 
    © 2020 The Japan Society of Vacuum and Surface Science. All rights reserved. Five kinds of activated carbon (AC1, AC2, AC3, AC4, and AC5) were prepared, and the characteristics (scanning electron microscopy images, specific surface area, pore-volume, pHpzc, surface functional groups, and surface hydroxyl groups) of each activated carbon were investigated. Additionally, the adsorption capability of activated carbons and adsorption mechanisms involved in adsorption of cationic and anionic dyes from the aqueous solution were evaluated. The results suggested that the treatment of activated carbon with silver (AC3), titanium oxide (AC4), or magnetic field (AC5) was not useful for increasing specific surface area and micropore volume. Moreover, the amount of cationic and anionic dyes adsorbed using activated carbon prepared from coconut shells (AC1 and AC2) were higher than that adsorbed using AC3, AC4, and AC5. Subsequently, the adsorption mechanism involved in adsorption of cationic and anionic dyes was also assessed. It was found that the amount of cationic and anionic dyes adsorbed was related to the specific surface area, micropore volume, and acidic or basic functional groups. Finally, the interactions between dyes and AC1 were elucidated in this study. Adsorption of dyes onto the AC1 surface was confirmed by the elemental distribution and X-ray photoelectron spectroscopy analysis. These results provide useful information on the surface interactions between the activated carbon and dyes (high molecular organic compounds).
  • Takehiro Nakamura; Eiko Yoshida; Takato Hara; Tomoya Fujie; Chika Yamamoto; Yasuyuki Fujiwara; Fumihiko Ogata; Naohito Kawasaki; Ryo Takita; Masanobu Uchiyama; Toshiyuki Kaji
    RSC Advances Royal Society of Chemistry (RSC) 10 (69) 42327 - 42337 2020 

    Stimulation of vascular endothelial cell proliferation by Zn-12 can be mediated by the ERK1/2 activation independently of the FGF-2-FGFR pathway. Additionally, there may be other pathways involved in the Zn-12 stimulation.

  • Fumihiko Ogata; Yugo Uematsu; Takehiro Nakamura; Naohito Kawasaki
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan The Pharmaceutical Society of Japan 140 (12) 1463 - 1470 0031-6903 2020 
    To decrease the amount of waste biomass and develop a useful application. Coconut fiber (CF) was used to prepare a novel adsorbent to remove methylene blue (MB), which is a recalcitrant organic compound in the water environment. We were able to produce novel adsorbents such as CCF500 and CCF1000 by the calcination treatment of CF. The specific surface area and pore volume of CCF1000 were higher than those of CF or CCF500. Quantity of MB adsorbed was in the order; CCF5000.986). The adsorption mechanism of MB using CCF1000 was demonstrated in this study. The intensities of carbon (C), nitrogen (N), and sulfur (S) onto CCF1000 surface increased after adsorption of MB. In addition, the binding energies of nitrogen (1s) at approximately 400 eV and sulfur (2s and 2p) at approximately 165 and 230 eV which were generated after adsorption. Therefore, the adsorption of MB from aquatic solution was strongly involved with the physicochemical properties of CCF1000 surface. Our findings showed that CCF500 and CCF1000 could be produced from CF by calcination treatment, which demonstrates that the amount of waste biomass decreased. In particular, CCF1000 displays the capability to adsorb MB from aquatic solution. These results showed that CCF1000 could be a useful adsorbent for aquatic environment purification.
  • Fumihiko Ogata; Ryouhei Hayabuchi; Chalermpong Saenjum; Takehiro Nakamura; Naohito Kawasaki
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 140 (9) 1165 - 1173 2020 [Refereed]
     
    Relationship between water molecules and parent and hydroxypropylated cyclodextrins (denoted as CD and HP-CD) was assessed in this paper. The trends in ad-desorption isotherms of CD for water molecule were quite different compared to those of HP-CD. Ad-desorption isotherms of CD showed the hysteresis under our experimental conditions. The molar ratio of hydration (R-value) using α-CD, β-CD, γ-CD, HP-α-CD, HP-β-CD, and HP-γ-CD was 7.1, 11.4, 13.5, 12.5, 14.0, and 16.7, respectively. These results indicated that the adsorption capability of water molecule of HP-CD was greater than that of CD. Additionally, the changes in characteristics of CD and HP-CD at different water activity conditions were demonstrated. X-ray diffraction patterns were significantly different between CD and HP-CD. The crystal structure of HP-α-CD, HP-β-CD, and HP-γ-CD showed amorphous at different water activity conditions. Finally, sorption entropy and heat of sorption of water molecules were calculated in this experiment. In summary, these results provide useful information for understanding the relationship between water molecules and parent and hydroxypropylated cyclodextrins.
  • Takehiro Nakamura; Riku Nagafuji; Fumihiko Ogata; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 68 (4) 339 - 344 0009-2363 2020 [Refereed]
     
    In this study, we prepared novel Mg/Fe/Al hydroxides (MFA series: denoted by MFA1, MFA2, MF, and MA) and investigated their properties using scanning electron microscopy, X-ray diffraction, the specific surface area, and amount of hydroxyl groups. Additionally, the phosphate adsorption capabilities of the MFA series or Fe-Mg type hydrotalcites (FHT3.0 and FHT5.0) were evaluated by examining the effects of the solution pH and contact time, and analyzing the adsorption isotherm and desorption characteristics. In MFA1, a strong correlation exists between the amount of adsorbed phosphate ions and surface hydroxyl groups, with a correlation coefficient of 0.95. The adsorption kinetics data fitted using the pseudo-second-order model performs better than the pseudo-first-order model. The adsorption isotherm data were also fitted using both the Freundlich and Langmuir models. Finally, the phosphate ions adsorbed on the MFA1 surfaces were desorbed using sodium hydroxide solution. These results indicate that MFA1 offers great potential for phosphate ion adsorption from aqueous solutions and functions as a renewable adsorbent.
  • Fumihiko Ogata; Yuhei Kobayashi; Yugo Uematsu; Takehiro Nakamura; Naohito Kawasaki
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 140 (5) 729 - 737 0031-6903 2020 [Refereed]
     
    In this study, we evaluated the efficiency of fly ash (FA) recycling technology, produced from a coal-fired power plant, with the capability to adsorb cesium ion[Cs(I)] and strontium ion [Sr(II)] from aqueous phase. Zeolite was produced from FA by hydrothermal treatment in an alkaline solution. Zeolite 12, 24, and 48 have a Garronite structure. Moreover, the specific surface area of Zeolite was greater than that of FA. Zeolite 12 demonstrated the adsorption capability of Cs(I) and Sr(II) from aqueous phase. Adsorption isotherms data fitted both the Langmuir equation (correlation coefficient: >0.895) and the Freundlich equation (correlation coefficient: >0.881). In addition, the kinetic data fitted the pseudo-second-order model when compared to the pseudo-first-order model. Cs(I) and Sr(II) were selectively adsorbed by Zeolite 12 in complex solution system. Our findings indicate that Zeolite can be produced from FA by hydrothermal treatment in an alkaline solution and shows the capability to adsorb Cs(I) and Sr(II) from aqueous phase. Therefore, Zeolite can be useful adsorbent for purification in water environments.
  • Fumihiko Ogata; Shouko Iijima; Megumu Toda; Masashi Otani; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin PHARMACEUTICAL SOC JAPAN 68 (3) 292 - 297 0009-2363 2020 [Refereed]
     
    In this study, the adsorption capability of phosphate ion using a novel tri-metals complex hydroxide was evaluated for preventing the eutrophication in water environment. A nickel-aluminum-zirconium complex hydroxide (NAZ) was synthesized using each inorganic sulfate mixing ratio of 0.9 : 1.0 : 0.1 and was calcined at different temperatures. The characteristics of the NAZ were analyzed by scanning electron microscopy images, X-ray diffraction analysis, elemental distribution, and binding energy. Moreover, the amount adsorbed of phosphate ion onto uncalcined and calcined NAZ was measured. That of phosphate ions onto the uncalcined was the largest of all. These results suggested that the adsorption of phosphate ions tends to depend on the physicochemical properties (e.g., amount of hydroxyl groups, pore volumes, and pH) of the adsorbents. Moreover, the adsorption mechanism of phosphate ions was evaluated on the basis of binding energy and elemental analysis. After adsorption, the binding energy of phosphorus P (2s and 2p) peaked and the sulfur peak intensity S(2s) reduced. This result indicated that the adsorption mechanism of phosphate would be exchanged with sulfate ions.
  • Fumihiko Ogata; Yuhei Kobayashi; Yugo Uematsu; Takehiro Nakamura; Naohito Kawasaki
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan The Pharmaceutical Society of Japan 140 (5) 729 - 737 0031-6903 2020 [Refereed]
     
    In this study, we evaluated the efficiency of fly ash (FA) recycling technology, produced from a coal-fired power plant, with the capability to adsorb cesium ion[Cs(I)] and strontium ion [Sr(II)] from aqueous phase. Zeolite was produced from FA by hydrothermal treatment in an alkaline solution. Zeolite 12, 24, and 48 have a Garronite structure. Moreover, the specific surface area of Zeolite was greater than that of FA. Zeolite 12 demonstrated the adsorption capability of Cs(I) and Sr(II) from aqueous phase. Adsorption isotherms data fitted both the Langmuir equation (correlation coefficient: >0.895) and the Freundlich equation (correlation coefficient: >0.881). In addition, the kinetic data fitted the pseudo-second-order model when compared to the pseudo-first-order model. Cs(I) and Sr(II) were selectively adsorbed by Zeolite 12 in complex solution system. Our findings indicate that Zeolite can be produced from FA by hydrothermal treatment in an alkaline solution and shows the capability to adsorb Cs(I) and Sr(II) from aqueous phase. Therefore, Zeolite can be useful adsorbent for purification in water environments.
  • Fumihiko Ogata; Chalermpong Saenjum; Eri Nagahashi; Yuhei Kobayashi; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 68 (6) 546 - 551 2020 [Refereed]
     
    The water quality in a river (water environment) is very important for human health and aquatic organisms. In 2015, the highly regarded Water Resources Management Strategy of Thailand was announced by The Ministry of Industry in Thailand. In this study, the water quality of the Ping river in Northern Thailand, including Chiang Mai and Lamphun provinces, was focused on and measured for three different seasons (summer, rainy, and winter seasons). Anions (F-, Cl-, NO2-, NO3-, and SO42-) and cations (Na+, Mg2+, Si4+, S6+, K+, and Ca2+) were qualified by an ion chromatograph and an inductively coupled plasma optical emission spectrometry, respectively. The concentration of anions and cations (except for Mg2+ and Ca2+) in the Ping river at upstream (countryside) locations were lower than that at downstream (closer main city) locations, which indicated that the fertilizers, industrial or household wastewaters had been flowing into the Ping river at downstream locations. Additionally, the concentration of anions and cations in the rainy season was higher than other seasons. The present results provide the water quality of the Ping river which was not yet reported officially by the Thailand government.
  • Fumihiko Ogata; Takehiro Nakamura; Megumu Toda; Masashi Otani; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 68 (1) 70 - 76 0009-2363 2020 [Refereed]
     
    In this study, nickel-aluminium complex hydroxides at different molar ratios (nickel-aluminium = 1 : 2, 1 : 1, 2 : 1, 3 : 1, and 4 : 1, referred to as NA12, NA11, NA21, NA31, and NA41) were prepared, and their adsorption capability for chromium(VI) ion was investigated. Firstly, physicochemical characteristics (SEM images, X-ray diffraction (XRD) patterns, specific surface area, amount of hydroxyl groups, and surface pH) of nickel-aluminum complex hydroxide were evaluated. The amount of chromium(VI) ion adsorbed onto NA11 (15.3 mg/g) was greater than that adsorbed onto the other adsorbents. This research elucidated that the amount of chromium(VI) ion adsorbed using nickel-aluminium complex hydroxide was related to the adsorbent surface properties (r = 0.818-0.875). Subsequently, the adsorbent (NA11) surface before and after adsorption of chromium(VI) ion was evaluated, and chromium energy (577 and 586 eV) detected after adsorption onto the NA11 surface. These results revealed that the NA11 surface properties were very important for the removal of chromium(VI) ion from aqueous solution. In addition, the effects of pH, contact time, and temperature on the adsorption of chromium(VI) ion were evaluated. We confirmed a high recovery percentage of chromium(VI) ion when using sodium hydroxide solution at 10-1000 mmol/L (approximately greater than 80%) in this experimental condition. Thus, NA11 is a promising adsorbent for the removal of chromium(VI) ion from aqueous solution.
  • 医薬品適正使用の取り組み セレン含有院内製剤の水剤から錠剤への剤型変更後の評価
    覚野 律; 大橋 香菜子; 桑原 明日香; 脇 啓子; 仲村 弥栄子; 田邨 保之; 森 惠子; 木原 理絵; 中村 明美; 都市 美晴; 川端 成佐; 中尾 元紀; 大竹 裕子; 松野 純男; 緒方 文彦; 川崎 直人; 長井 紀章
    国立病院総合医学会講演抄録集 国立病院総合医学会 73回 WS11 - 4 2019/11 [Refereed]
  • Kaito Yamashiro; Shigeharu Tanei; Siriporn Burapadaja; Fumihiko Ogata; Naohito Kawasaki
    Journal of allied health sciences Society of Allied Health Services 10 (2) 69 - 78 2185-0399 2019/10 [Refereed]
  • コーヒー豆かすによる飲料水中の鉛イオンの除去能の評価と吸着制御因子の解明
    山城 海渡; 緒方 文彦; 中村 武浩; 川崎 直人
    The Journal of Toxicological Sciences (一社)日本毒性学会 44 (Suppl.) S238 - S238 0388-1350 2019/06
  • ニッケルおよびコバルトを基材とした金属複合水酸化物による水質浄化効果および細胞毒性に関する基礎研究
    緒方 文彦; 中村 武浩; 中島 誠隆; 川崎 直人
    The Journal of Toxicological Sciences (一社)日本毒性学会 44 (Suppl.) S283 - S283 0388-1350 2019/06
  • 大学生の朝食欠食や睡眠状況と身体的及び精神的健康指標との関連性
    川崎 直人; 佐川 和則; 緒方 文彦; 山城 海渡; 中村 武浩
    日本薬学会年会要旨集 (公社)日本薬学会 139年会 (3) 200 - 200 0918-9823 2019/03 [Refereed]
  • 健康障害防止のための変敗食用油における脂肪酸組成の改善
    緒方 文彦; 阿美 はるか; 中村 武浩; 川崎 直人
    日本薬学会年会要旨集 (公社)日本薬学会 139年会 (3) 215 - 215 0918-9823 2019/03 [Refereed]
  • 流通法による活性白土を用いた導電率の低減に関する検討
    永橋 瑛梨; 岩城 宇亮; 緒方 文彦; 中村 武浩; 川崎 直人
    日本薬学会年会要旨集 (公社)日本薬学会 139年会 (3) 219 - 219 0918-9823 2019/03 [Refereed]
  • Fumihiko Ogata; Noriaki Nagai; Mao Kishida; Takehiro Nakamura; Naohito Kawasaki
    JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING ELSEVIER SCI LTD 7 (1) 2213-2929 2019/02 [Refereed]
     
    In this study, Fe-Mg type hydrotalcite at different molar ratios (Mg/Fe=3.0 and 5.0, Fe-HT3.0 and Fe-HT5.0) was prepared, and its physicochemical properties were investigated. The adsorption isotherms were measured, and the effects of contact time, temperature, and pH on the adsorption of phosphate ions, and the ad-desorption capability were evaluated. Elemental analysis and binding energy values of the Fe-HT adsorbent surface before and after adsorption of phosphate ions indicated that the adsorption mechanism of phosphate ions was related to the physicochemical properties of adsorbent surface. Adsorption mechanism of phosphate ion relates to ion exchange, electrostatic attraction, and surface inner sphere complex formation in this study. Moreover, the phosphate ions adsorbed onto Fe-HT were easily desorbed using sodium hydroxide solution; thus, five cycles of ad-desorption were carried out. Collectively, these results suggest that Fe-HT is promising for the adsorption and recovery of phosphate ions using sodium hydroxide solution.
  • Ogata, F.; Nakamura, T.; Nakajima, M.; Toda, M.; Otani, M.; Kawasaki, N.
    Journal of Environmental Chemical Engineering 7 (4) 2019 [Refereed]
     
    © 2019 Elsevier Ltd. All rights reserved. A nickel-cobalt complex hydroxide was prepared by mixing nickel and cobalt in the ratio of 9:1 (NC91-virgin) and then performing calcination at 280 °C (NC91-280). The adsorption of PO43- by both NC91-virgin and NC91-280 in a complex solution system was evaluated. A higher amount of PO43- was adsorbed by NC91-280 than by NC91-virgin. These results suggest that the adsorption of PO43- is related to the physicochemical properties of the adsorbents. In addition, PO43- was selectively adsorbed by NC91-280 in the complex solution. A pH of approximately 2-3 was optimal for the adsorption of PO43-. The amount of adsorbed PO43- increased with temperature. The adsorption isotherm data were applied to both the Freundlich and Langmuir models. NC91-280 was reused for the adsorption/desorption of PO43- at five times. We could confirm a high recovery percentage of PO43- using a NaOH solution at 1000 mmol/L under the tested experimental conditions. Moreover, we could elucidate the mechanism behind PO43- adsorption in the complex solution. The intensity of P on the surface of NC91-280 increased after adsorption, and peaks of P(2s) and P(2p) were detected by X-ray photoelectron spectroscopy. Finally, we showed that NC91-280 had low a cytotoxic effect on vascular endothelial cells.
  • Fumihiko Ogata; Noriaki Nagai; Takehiro Nakamura; Naohito Kawasaki
    Chemical & pharmaceutical bulletin 67 (10) 1168 - 1170 0009-2363 2019 [Refereed]
     
    In this study, the adsorption capability of Fe-HT3.0 for nitrite and nitrate ions in a binary solution system was evaluated. It was found that the amount of nitrite and nitrate ions adsorbed in a single solution (1.19 and 1.27 mmol/g, respectively) was higher than that in a binary solution (0.36 and 0.90 mmol/g, respectively). Equilibrium adsorption was attained within 6-24 h. The adsorption data were fitted to a pseudo-second-order model (correlation coefficient: 0.999), and indicated that the adsorption of both nitrite and nitrate ions is controlled by chemical sorption. Additionally, the binding energies before and after the adsorption of nitrite and nitrate ions in the binary solution system were measured. After adsorption, new nitrogen peaks (approx. 399 and 403 eV) were detected. The results of this study show the potential of Fe-HT3.0 for the removal of nitrite and nitrate ions from aqueous solution systems.
  • Nagai, N.; Ogata, F.; Yamaguchi, M.; Fukuoka, Y.; Otake, H.; Nakazawa, Y.; Kawasaki, N.
    International journal of molecular sciences 20 (15) 2019 [Refereed]
     
    This study designed the transdermal formulations containing indomethacin (IMC)-1% IMC was crushed with 0.5% methylcellulose and 5% 2-hydroxypropyl-β-cyclodextrin by the bead mill method, and the milled IMC was gelled with or without 2% l-menthol (a permeation enhancer) by Carbopol® 934 (without menthol, N-IMC gel; with menthol, N-IMC/MT gel). In addition, the drug release, skin penetration and percutaneous absorption of the N-IMC/MT gel were investigated. The particle sizes of N-IMC gel were approximately 50-200 nm, and the combination with l-menthol did not affect the particle characterization of the transdermal formulations. In an in vitro experiment using a Franz diffusion cell, the skin penetration in N-IMC/MT gel was enhanced than the N-IMC gel, and the percutaneous absorption (AUC) from the N-IMC/MT gel was 2-fold higher than the N-IMC gel. On the other hand, the skin penetration from the N-IMC/MT gel was remarkably attenuated at a 4 °C condition, a temperature that inhibits all energy-dependent endocytosis. In conclusion, this study designed transdermal formulations containing IMC solid nanoparticles and l-menthol, and found that the combination with l-menthol enhanced the skin penetration of the IMC solid nanoparticles. In addition, the energy-dependency of the skin penetration of IMC solid nanoparticles was demonstrated. These findings suggest the utility of a transdermal drug delivery system to provide the easy application of solid nanoparticles (SNPs).
  • Ogata, F.; Nagai, N.; Kishida, M.; Nakamura, T.; Kawasaki, N.
    Journal of Environmental Chemical Engineering 7 (1) 2213-3437 2019 [Refereed]
  • Nagai, N.; Ogata, F.; Otake, H.; Nakazawa, Y.; Kawasaki, N.
    International Journal of Nanomedicine 14 1213 - 1227 1176-9114 2019 [Refereed]
     
    Purpose: We previously found that ophthalmic formulations containing nanoparticles prepared by a bead mill method lead to an increase in bioavailability in comparison with traditional formulations (solution type). However, the transcorneal penetration pathway for ophthalmic formulations has not been explained yet. In this study, we investigated the mechanism of transcorneal penetration in the application of ophthalmic formulations containing indomethacin nanoparticles (IMC-NPs). Materials and methods: IMC-NPs was prepared by the bead mill method. For the analysis of energy-dependent endocytosis, corneal epithelial (HCE-T) cell monolayers and removed rabbit cornea were thermoregulated at 4°C, where energy-dependent endocytosis is inhibited. In addition, for the analysis of different endocytosis pathways using pharmacological inhibitors, inhibitors of caveolae-mediated endocytosis (54 µM nystatin), clathrin-mediated endocytosis (40 µM dynasore), macropinocytosis (2 µM rottlerin) or phagocytosis (10 µM cytochalasin D) were used. Results: The ophthalmic formulations containing 35-200 nm sized indomethacin nanoparticles were prepared by treatment with a bead mill, and no aggregation or degradation of indomethacin was observed in IMC-NPs. The transcorneal penetration of indomethacin was significantly decreased by the combination of nystatin, dynasore and rottlerin, and the decreased penetration levels were similar to those at 4°C in HCE-T cell monolayers and rabbit cornea. In the in vivo experiments using rabbits, dynasore and rottlerin tended to decrease the transcorneal penetration of indomethacin (area under the drug concentration - time curve in the aqueous humor [AUCAH]), and the AUCAH in the nystatin-treated rabbit was significantly lower than that in non-treatment group. In addition, the AUCAH in rabbit corneas undergoing multi-treatment was obviously lower than that in rabbit corneas treated with each individual endocytosis inhibitor. Conclusion: We found that three energy-dependent endocytosis pathways (clathrin-dependent endocytosis, caveolae-dependent endocytosis and macropinocytosis) are related to the trans-corneal penetration of indomethacin nanoparticles. In particular, the caveolae-dependent endocytosis is strongly involved.
  • Ogata, F.; Nagai, N.; Toda, M.; Otani, M.; Nakamura, T.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin 67 (5) 487 - 492 0009-2363 2019 [Refereed]
     
    A new mixed metal hydroxide adsorbent (NA11, molar ratioNi-Al = 1 : 1) was prepared and its physicochemical properties (specific surface area, amount of hydroxyl group, scanning electron microscopy images, X-ray diffraction analysis, elemental distribution, and binding energy) were studied. In addition, the amount of borate ion adsorbed using several adsorbents, including NA11, was evaluated in this study. The specific surface area of and amount of hydroxyl group in NA11 was greater than those of the other studied adsorbents. The amount of borate ion adsorbed showed similar trends to those of the specific surface area and number of hyrdroxyl groups, which indicated that the adsorption mechanism of borate ion was related to the specific surface area and the amount of hydroxyl group. After adsorption, the binding energy of boron B(1s) peaked, and the sulfur peak intensity S(2s) and S(2p) reduced. These results suggest that ion exchange between borate and sulfate ions was one of the adsorption mechanisms. Equilibrium adsorption was reached within 6 h in the case of NA11. These data were fitted into a pseudo-second-order model (r = 0.813-0.998). The solution pH affected the capacity of NA11 for adsorbing borate ion from aqueous solution. It was found that adsorbance was greatest at pH 10. Adsorption isotherm data were fitted to both the Freundlich (r = 0.986-0.994) and Langmuir (r = 0.997-0.999) isotherm equations. Collectively, it is suggested that NA11 is prospectively useful for the adsorption of borate ion from aqueous solutions.
  • Fumihiko Ogata; Takehiro Nakamura; Naohito Kawasaki
    JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING ELSEVIER SCI LTD 6 (4) 4459 - 4466 2213-2929 2018/08 [Refereed]
     
    In this study, we prepared wheat bran (WB), a type of waste biomass, and studied the characteristics of virgin WB and WB calcined at 200, 400, 600, 800, and 1000 degrees C (denoted by WB200, WB400, WB600, WB800, and WB1000). Subsequently, their adsorption isotherms, kinetics, and regeneration were evaluated. Specific surface area of calcined WB is larger compared to that of virgin WB. Amount of molybdenum (Mo) adsorbed is in the following order: WB400 (0 mg/g) = WB600 (0 mg/g) < WB800 (2.9 mg/g) < WB200 (12.9 mg/g) < WB (24.7 mg/g) < WB1000 (29.8 mg/g). The data for adsorption isotherms was applied to both the Freundlich (0.911-0.989) and the Langmuir (0.985-0.992) models. The amount of Mo adsorbed increased with increasing temperature and decreasing pH of the solution. We confirmed that the intensity of Mo on the adsorbent surface was greater after the adsorption treatment than before the treatment. In addition, the amount of Mo adsorbed on virgin WB was greater than that adsorbed on WB treated with different concentrations of hydrochloric acid, which suggests that the adsorption mechanism was related to the three-dimensional protein structure. Finally, adsorbed Mo on WB could be easily desorbed by treatment with sodium hydroxide solution. The recovery percentage of Mo using 1 and 100 mmol/L sodium hydroxide solution is 95.0% and 94.2% respectively. These results indicate that WB has great potential for Mo adsorption from aqueous solutions.
  • Noriaki Nagai; Fumihiko Ogata; Miyu Ishii; Yuya Fukuoka; Hiroko Otake; Yosuke Nakazawa; Naohito Kawasaki
    International journal of molecular sciences 19 (7) 1422-0067 2018/07 [Refereed]
     
    We previously designed a novel transdermal formulation containing ketoprofen solid nanoparticles (KET-NPs formulation), and showed that the skin penetration from the KET-NPs formulation was higher than that of a transdermal formulation containing ketoprofen microparticles (KET-MPs formulation). However, the precise mechanism for the skin penetration from the KET-NPs formulation was not clear. In this study we investigated whether energy-dependent endocytosis relates to the transdermal delivery from a 1.5% KET-NPs formulation. Transdermal formulations were prepared by a bead mill method using additives including methylcellulose and carbopol 934. The mean particle size of the ketoprofen nanoparticles was 98.3 nm. Four inhibitors of endocytosis dissolved in 0.5% DMSO (54 μM nystatin, a caveolae-mediated endocytosis inhibitor; 40 μM dynasore, a clathrin-mediated endocytosis inhibitor; 2 μM rottlerin, a macropinocytosis inhibitor; 10 μM cytochalasin D, a phagocytosis inhibitor) were used in this study. In the transdermal penetration study using a Franz diffusion cell, skin penetration through rat skin treated with cytochalasin D was similar to the control (DMSO) group. In contrast to the results for cytochalasin D, skin penetration from the KET-NPs formulation was significantly decreased by treatment with nystatin, dynasore or rottlerin with penetrated ketoprofen concentration-time curves (AUC) values 65%, 69% and 73% of control, respectively. Furthermore, multi-treatment with all three inhibitors (nystatin, dynasore and rottlerin) strongly suppressed the skin penetration from the KET-NPs formulation with an AUC value 13.4% that of the control. In conclusion, we found that caveolae-mediated endocytosis, clathrin-mediated endocytosis and macropinocytosis are all related to the skin penetration from the KET-NPs formulation. These findings provide significant information for the design of nanomedicines in transdermal formulations.
  • 水溶性薬物の角膜透過性向上を目指して：チモロールマレイン酸・マグネシウムヒドロキシドナノ粒子配合剤の開発
    NAKAZAWA Yosuke
    日本眼科学会雑誌 122 (1) 61 - 62 2018/01
  • Nagai, N.; Ogata, F.; Ishii, M.; Fukuoka, Y.; Otake, H.; Nakazawa, Y.; Kawasaki, N.
    International Journal of Molecular Sciences International Journal of Molecular Sciences 19 (7) 2138  1661-6596 2018 [Refereed]
     
    © 2018 by the authors. Licensee MDPI, Basel, Switzerland. We previously designed a novel transdermal formulation containing ketoprofen solid nanoparticles (KET-NPs formulation), and showed that the skin penetration from the KET-NPs formulation was higher than that of a transdermal formulation containing ketoprofen microparticles (KET-MPs formulation). However, the precise mechanism for the skin penetration from the KET-NPs formulation was not clear. In this study we investigated whether energy-dependent endocytosis relates to the transdermal delivery from a 1.5% KET-NPs formulation. Transdermal formulations were prepared by a bead mill method using additives including methylcellulose and carbopol 934. The mean particle size of the ketoprofen nanoparticles was 98.3 nm. Four inhibitors of endocytosis dissolved in 0.5% DMSO (54 µM nystatin, a caveolae-mediated endocytosis inhibitor; 40 µM dynasore, a clathrin-mediated endocytosis inhibitor; 2 µM rottlerin, a macropinocytosis inhibitor; 10 µM cytochalasin D, a phagocytosis inhibitor) were used in this study. In the transdermal penetration study using a Franz diffusion cell, skin penetration through rat skin treated with cytochalas
  • Ogata, F.; Ueta, E.; Kawasaki, N.
    Journal of Industrial and Engineering Chemistry 59 56 - 63 1226-086X 2018 [Refereed]
     
    © 2017 The Korean Society of Industrial and Engineering Chemistry In the present study, we prepared a newly adsorbent, Iron–Magnesium-type hydrotalcite (FHT), at different molar ratios (FHT3.0; Mg2+/Fe3+ = 3.0 and FHT5.0; Mg2+/Fe3+ = 5.0) for removing heavy metal ions. Characteristics of FHT and arsenite (As(III)) and hexavalent chromium (Cr(VI)) adsorption capability onto that were evaluated. Amount adsorbed of As(III) and Cr(VI) increased with raising temperatures. Amount adsorbed of heavy metal ions onto FHT in the single liquid phase was smaller than that in the mixed liquid phase, which suggests that the amount adsorbed was affected by the adsorbent properties, interlayer space, and solution pH.
  • Ogata, F.; Nagahashi, E.; Kobayashi, Y.; Nakamura, T.; Kawasaki, N.
    e-Journal of Surface Science and Nanotechnology 16 229 - 235 1348-0391 2018 [Refereed]
     
    © 2018 The Japan Society of Vacuum and Surface Science. This paper shows the efficacy of the combination of ozonation and adsorbent treatment in removing cationic and anionic dyes (methylene blue and acid orange 7, respectively) and chemical oxygen demand (COD) from wastewater. The adsorbent was prepared with coffee ground, rice bran, and soybean bran as sources of waste biomass, and was calcined at 1000◦C. We demonstrated three methods, namely, singular ozonation, singular adsorbent treatment, and the combination of the two treatments. The removal percentage of dye and COD by ozonation was greater than that by adsorbent treatment. However, the incomplete removal of dye and COD through ozonation suggested that singular treatment is not sufficient for this purpose. Subsequently, we evaluated the combination treatment; the removal percentage of dye and COD by this treatment was higher than those from the singular treatments, which indicates that the adsorption and degradation capacities were enhanced. In addition, the calcined adsorbent could be used at least four times. These results show the novelty and utility of this treatment for the removal of dye and COD from wastewater containing dye.
  • Ogata, F.; Obayashi, M.; Nagahashi, E.; Nakamura, T.; Kawasaki, N.
    Journal of Oleo Science 67 (1) 95 - 103 1345-8957 2018 [Refereed]
     
    In this study, we prepared calcium silicate at different molar ratios (Ca:Si=1:3, 1:6, and 1:9 refer to CAS-30S, CAS-60S, and CAS-90S, respectively) with water addition. The adsorbent characteristics (specific surface area, pore volume, mean pore diameter, and elemental analysis) were measured and the effect of water addition on the adsorbent surface for the prevention of deterioration was evaluated. In addition, the deterioration of soybean oil (SO) subjected to heating and aeration was investigated based on the acid value (AV) and carbonyl value (CV). The specific surface area increased in the order CAS-60S (160.51 m2/g) < CAS-30S (182.61 m2/g) < CAS-90S (204.19 m2/g). Deterioration of SO could be induced by heating and aeration with AV and CV of 1.4 mg/g and 102.9 µmol/g, respectively. The adsorbent (CAS-30S and CAS-90S) with water addition (25% and 50%) was found to decrease the AV, indicating that a small amount of water addition to adsorbent surface is important for the decreasing of AV. In addition, the correlation between the decrease in AV and the specific surface area is strongly positive (R value: 0.968). The adsorption mechanism is thought to involve interactions between the polar compounds (free fatty acids) in the SO (nonaqueous phase) and the water layer (containing calcium ions released from the adsorbent) on the adsorbent surface. In summary, the data obtained in this study provide useful information for preventing the deterioration of SO and prolonging the oil life cycle.
  • Ogata, F.; Nagai, N.; Ueta, E.; Nakamura, T.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 66 (3) 295 - 302 0009-2363 2018 [Refereed]
     
    In this study, we prepared novel adsorbents containing virgin and calcined tapioca products for removing strontium (Sr(II)) and cesium (Cs(I)) from aqueous solutions. The characteristics of tapioca, along with its capacity to adsorb Sr(II) and Cs(I), were evaluated. Multiple tapioca products were prepared and tested. The adsorbent prepared by boiling the tapioca followed by calcination at 300°C (BTP300) was the most effective. In addition, adsorption was affected by the adsorbent's surface properties. The Sr(II) and Cs(I) adsorbed onto BTP300 could be recovered through desorption by hydrochloric acid at different concentrations, which indicates that BTP300 can be used several times for adsorption/desorption. The results of this study suggest that BTP300, which was produced from tapioca biomass, can remove Sr(II) and Cs(I) from aqueous solutions.
  • Ogata, F.; Nagai, N.; Kariya, Y.; Nagahashi, E.; Kobayashi, Y.; Nakamura, T.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 66 (4) 458 - 465 0009-2363 2018 [Refereed]
     
    In this study, we prepared Fe-Mg-type hydrotalcites (Fe-HT3.0 and Fe-HT5.0) with different molar ratios and evaluated their adsorption capability for nitrite and nitrate ions from aqueous solution. Fe-HT is a typical hydrotalcite-like layered double hydroxide. Adsorption isotherms, as well as the effects of contact time and pH were investigated, and it was found that Fe-HT can adsorb larger amounts of nitrite and nitrate ions than Al-HT (normal-type hydrotalcite). Adsorption isotherm data were fitted to both Freundlich (correlation coefficient: 0.970-1.000) and Langmuir (correlation coefficient: 0.974-0.999) equations. Elemental analysis and binding energy of Fe-HT surface before and after adsorption indicated that the adsorption mechanism was related to the interaction between the adsorbent surface and anions. In addition, the ion exchange process is related to the adsorption mechanism. The adsorption amount increased with increasing temperature (7-25°C). The experimental data fit the pseudo-second-order model better than the pseudo-first-order model. The effect of pH on adsorption was not significant, which suggested that Fe-HT could be used over a wide pH range (4-12). These results indicate that Fe-HT is a good adsorbent for the removal of nitrite and nitrate ions from aqueous solution.
  • Ogata, F.; Nakamura, T.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin 66 (5) 585 - 588 0009-2363 2018 [Refereed]
     
    In this study, the degradation of methylene blue (MB) and acid orange II (ORII) by the Fenton reaction was improved by using HCl and HNO3. In addition, the effects of pH, temperature, concentration of Fenton's reagent, and adjustment reagent of solution pH on the decoloration were evaluated. The results showed that the optimal pH for decoloration of MB and ORII was 2.5 and that the decoloration of MB and ORII increased with higher temperature and concentration of Fenton's reagent. Moreover, the decoloration in the Fenton-reaction process with HCl and HNO3 was greater than the decoloration with H2SO4 by approximately 4.3-5.6 and 1.7-5.6 times for MB and 3.2-3.6 and 4.6-7.2 times for ORII compared to with H2SO4. These results indicated that Fenton-reaction with HCl and HNO3 could be useful for the degradation technology of dyes compared to generally Fenton-reactions.
  • Ogata, F.; Toda, M.; Otani, M.; Nakamura, T.; Kawasaki, N.
    Water science and technology : a journal of the International Association on Water Pollution Research 2017 (3) 913 - 921 0273-1223 2018 [Refereed]
     
    We prepared a variety of nickel-aluminum complex hydroxides, investigated their physicochemical properties, and evaluated their ability to adsorb phosphate ions (the molar ratios of nickel to aluminum, 1:2, 1:1, 2:1, 3:1, and 4:1, are referred to as NA12, NA11, NA21, NA31, and NA41). NA12 and NA11 have amorphous structures; their specific surface areas and the concentration of associated hydroxyl groups were greater than those of other adsorbents. The number of phosphate ions adsorbed onto NA12 and NA11 was greater than that onto other adsorbents. These results indicated that the phosphate ion adsorption is related to the specific surface area and the amount of hydroxyl groups. The adsorption isotherm data, and the effects of contact time and pH on the adsorption were investigated; our results implied that both the Freundlich equation model and the pseudo-second-order kinetic model describe the adsorption of phosphate ions by NA11. We showed that phosphate ions adsorbed onto NA11 can be desorbed by sodium hydroxide solution at different concentrations and that NA11 could be reused for at least three repeated cycles of phosphate ion adsorption and desorption. This study illustrates that NA11 has the potential for practical application as an adsorbent for phosphate ions from wastewater.
  • Ogata, F.; Nakamura, T.; Kawasaki, N.
    Journal of Environmental Chemical Engineering 6 (4) 4459 - 4466 2213-3437 2018 [Refereed]
  • Nagai, N.; Ogata, F.; Otake, H.; Nakazawa, Y.; Kawasaki, N.
    International Journal of Nanomedicine 13 5215 - 5229 1176-9114 2018 [Refereed]
     
    Purpose: In the clinical setting, raloxifene, a second-generation selective estrogen receptor modulator, is administered orally; however, the bioavailability (BA) is only 2% because of its poor solubility in aqueous fluids and its extensive first-pass metabolism. Therefore, it is expected that the development of a transdermally delivered formulation may reduce the necessary dose without compromising its therapeutic efficacy. In this study, we designed transdermal formulations containing raloxifene nanoparticles and evaluated their usefulness for osteoporosis therapy. Methods: Raloxifene was crushed with methylcellulose by the bead mill method, and the milled raloxifene was gelled with or without menthol (a permeation enhancer) by Carbopol® 934 (without menthol, Ral-NPs; with menthol, mRal-NPs). The drug release and transdermal penetration were measured using a Franz diffusion cell, and the therapeutic evaluation of osteoporosis was determined in an ovariectomized rat model. Results: The mean particle size of raloxifene in the transdermal formulation (Ral-NPs) was 173.7 nm. Although the raloxifene released from Ral-NPs remained in the nanoparticle state, the skin penetration of raloxifene nanoparticles was prevented by the stratum corneum in rat. On the other hand, inclusion of menthol in the formulation attenuated the barrier function of the stratum corneum and permitted the penetration of raloxifene nanoparticles through the skin. Moreover, macropinocytosis relates to the skin penetration of the formulation including menthol (mRal-NPs), since penetration was inhibited by treatment with 2 µM rottlerin, a macropinocytosis inhibitor. In addition, the application of 0.3% mRal-NPs (once a day) attenuated the decreases in calcium level and stiffness of the bones of ovariectomized rat. Conclusion: We prepared raloxifene solid nanoparticles by a bead mill method and designed a novel transdermal formulation containing nanoparticles and permeation enhancers. These trans-dermal formulations overcome the barrier properties of the skin and show high drug penetration through the transdermal route (BA 8.5%). In addition, we found that raloxifene transdermal formulations are useful for the treatment of osteoporosis in ovariectomized rat.
  • 山城 海渡; 緒方 文彦; 川崎 直人
    薬学雑誌 (公社)日本薬学会 137 (8) 1035 - 1040 0031-6903 2017/08 [Refereed]
     
    20〜50歳代の男性275名及び女性977名を対象とした。男性において加齢と有意な関係を認めた項目は、「現在、たばこを習慣的に吸っている」、「20歳のときの体重から10kg以上増加している」、「日常生活において歩行又は同等の身体活動を1日1時間以上実施している」、「夕食前に間食をとることが週に3回以上ある」であった。女性では、「20歳のときの体重から10kg以上増加している」、「この1年間で体重の増減が±3kg以上あった」、「1回30分以上の軽く汗をかく運動を週2日以上、1年以上実施している」、「就寝前の2時間以内に夕食をとることが週に3回以上ある」、「夕食前に間食をとることが週に3回以上ある」、「朝食を抜くことが週に3回以上ある」であった。花粉症と生活習慣との開連性について、名義ロジスティック回帰分析により解析し、男性において喫煙と花粉症との間に有意な関連性を認めた。花粉症と毛髪中ミネラル濃度との関連性について名義ロジスティック回帰分析により解析し、花粉症患者において、男性では鉄が低く、女性ではカルシウム、クロム、カドミウムが低く、セレンが高かった。
  • Ogata Fumihiko; Nakamura Takehiro; Ueta Erimi; Nagahashi Eri; Kobayashi Yuhei; Kawasaki Naohito
    JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING 5 (4) 3083 - 3090 2213-3437 2017/08 [Refereed]
  • Ogata, F.; Nakamura, T.; Ueta, E.; Nagahashi, E.; Kobayashi, Y.; Kawasaki, N.
    Journal of Environmental Chemical Engineering ELSEVIER SCI LTD 5 (4) 3083 - 3090 2213-2929 2017 [Refereed]
     
    A novel Fe-Mg type hydrotalcite at different Mg2+/Fe3+ ratio (Fe-HT3.0 and Fe-HT5.0) were prepared, and their properties were investigated by scanning electron microscopy, X-ray diffraction analysis, electron probe microanalysis, specific surface area, and binding energy studies. In addition, the adsorption capability of tungsten onto Fe-HT3.0 and Fe-HT5.0 was evaluated. The amount of tungsten adsorbed onto Fe-HT3.0 and Fe-HT5.0 increased with increasing temperatures. The results of the adsorption isotherm studies suggested that tungsten adsorption can be well described by both the Freundlich (R-2: 0.895-0.998) and Langmuir (R-2: 0.890-0.998) equations. The tungsten adsorbed onto the adsorbent surface was confirmed by electron probe microanalysis and binding energy. The obtained data on thermodynamic parameters showed a decrease in Delta G with the increase in temperature, which indicated that tungsten adsorption was spontaneous. The adsorption of tungsten onto FeHT3.0 and Fe-HT5.0 reached equilibrium within 3 and 10 h, respectively, and the adsorption kinetic data fit the pseudo-second-order kinetic model better than the pseudo-first-order kinetic model. The optimal pH condition for the adsorption of tungsten onto Fe-HT3.0 and Fe-HT5.0 is approximately 2.0. The results of this study indicate that the adsorption mechanism of tungsten onto Fe-HT3.0 and Fe-HT5.0 involves ion exchange, electrostatic attraction, and surface inner-sphere complex formation between tungsten ion and hydroxide ion. Finally, tungsten adsorbed onto the Fe-HT3.0 and Fe-HT5.0 surfaces was desorbed by sodium hydroxide solution at different concentrations. Collectively, these results suggest that Fe-HT3.0 and Fe-HT5.0 can be useful for the adsorption and recovery of tungsten from aqueous solutions.
  • Nakamura, T.; Yoshida, E.; Fujie, T.; Ogata, F.; Yamamoto, C.; Kawasaki, N.; Kaji, T.
    Journal of Toxicological Sciences JAPANESE SOC TOXICOLOGICAL SCIENCES 42 (6) 683 - 687 0388-1350 2017 [Refereed]
     
    Organic-inorganic hybrid molecules, which are composed of organic-ligand(s) and metal(s), are indispensable as synthetic reagents in chemistry, but they have made very little in the way of contributions to biological research. Previously, we reported that the cytotoxicity of organic-inorganic hybrid molecules in vascular endothelial cells depends on interactions between the intramolecular metal and ligand, but remains independent of the hydrophobicity of the intramolecular metal(s). Herein, we show a synergistic cytotoxicity produced by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in vascular endothelial cells that depends on the intracellular accumulation of copper.
  • Nagai, N.; Ogata, F.; Otake, H.; Kawasaki, N.; Nakazawa, Y.; Kanai, K.; Okamoto, N.; Shimomura, Y.
    Experimental Eye Research ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 165 118 - 124 0014-4835 2017 [Refereed]
     
    We prepared magnesium hydroxide (MH) nanoparticles by a bead mill method, and investigated whether the co-instillation of MH nanoparticles improves the low transcorneal penetration of water-soluble drugs, such as the anti-glaucoma eye drug timolol maleate (TM). MH particle size was decreased by the bead mill treatment to a mean particle size of 71 nm. In addition, the MH nanoparticles were highly stable. Next, we demonstrated the effect of MH nanoparticles on the corneal surface. MH shows only slight solubility in lacrimal fluid, and the instillation of MH nanoparticles for 14 days did not affect the behavior (balance of secretion and excretion) of the lacrimal fluid in rabbit corneas. Moreover, there was no observable corneal toxicity of MH nanoparticles, and treatment with MH nanoparticles enhanced the intercellular space ratio in the eyes of rats. MH alone did not permeate into the cornea; however, the co-instillation of MH nanoparticles and dissolved TM (nMTFC) enhanced the corneal penetration of TM. In addition, the intraocular pressure (IOP)-reducing effect of nMTFC was significantly higher than those of the TM solution or the co-instillation of MH microparticles and TM. In conclusion, we found that MH nanoparticles enhance the corneal penetration of dissolved TM with no observable corneal stimulation or obstruction of the nasolacrimal duct by the MH nanoparticles. It is possible that the co-instillation of MH nanoparticles may provide a useful way to improve the bioavailability of water-soluble drugs in the ophthalmic field. These findings provide significant information that can be used to design further studies aimed at developing anti-glaucoma eye drugs.
  • Ogata, F.; Nagai, N.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin The Pharmaceutical Society of Japan 65 (3) 268 - 275 0009-2363 2017 
    In this study, the adsorption capability of cationic dyes, which were methylene blue and crystal violet, by poly-γ-glutamic acid (PGA) in a single or binary solution system was investigated. The effect of the molecular weight of PGA, initial dye concentration, solution pH, and temperature on the adsorption of dyes was evaluated. The adsorption mechanism of dyes onto PGA was the interaction between -COOH group on the PGA surface and the polarity groups of dyes. These results indicated that PGA is useful for removal of dyes and cationic organic compounds from a single or binary solution system.
  • Fumihiko Ogata; Ryosuke Satoh; Ayako Kita; Reiko Sugiura; Naohito Kawasaki
    The Journal of toxicological sciences JAPANESE SOC TOXICOLOGICAL SCIENCES 42 (2) 159 - 166 0388-1350 2017 [Refereed]
     
    The distribution of metal and metalloid species in each of the cell compartments is termed as "metallome". It is important to elucidate the molecular mechanism underlying the beneficial or toxic effects exerted by a given metal or metalloid on human health. Therefore, we developed a method to measure intracellular metal ion concentration (particularly, intracellular calcium ion) in fission yeast. We evaluated the effects of nitric acid (HNO3), zymolyase, and westase treatment on cytolysis in fission yeast. Moreover, we evaluated the changes in the intracellular calcium ion concentration in fission yeast in response to treatment with/without micafungin. The fission yeast undergoes lysis when treated with 60% HNO3, which is simpler and cheaper compared to the other treatments. Additionally, the intracellular calcium ion concentration in 60% HNO3-treated fission yeast was determined by inductively coupled plasma atomic emission spectrometry. This study yields significant information pertaining to measurement of the intracellular calcium ion concentration in fission yeast, which is useful for elucidating the physiological or pathological functions of calcium ion in the biological systems. This study is the first step to obtain perspective view on the effect of the metallome in biological systems.
  • Nagai, N.; Ogata, F.; Deguchi, S.; Ueno, A.; Kawasaki, N.; Ito, Y.
    Biological and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 40 (4) 444 - 450 0918-6158 2017 [Refereed]
     
    We attempted to design a combination ointment containing solid tranilast nanoparticles and dissolved sericin as a wound-healing drug (TS-combination ointment), and evaluated its usefulness as therapy for wound-healing deficits in streptozotocin-induced diabetic rat (STZ rat) using kinetic analyses as an index. Solid tranilast nanoparticles were prepared by bead mill methods with low-substituted methylcellulose; the mean particle size of the tranilast nanoparticles was 70 nm. The ointment was designed to contain the tranilast nanoparticles plus sericin powder and/or Carbopol® 934. Skin wound healing in STZ rats begins significantly later than in normal rats. Although the skin wound healing rate in STZ rats treated with an ointment containing tranilast nanoparticles was lower than in STZ rats treated with vehicle, the ointment was effective in reducing redness. An ointment containing sericin enhanced the skin-healing rate, but the preventive effect on redness was weak. On the other hand, the combination of tranilast and sericin increased both the skin healing rate and reduction in redness. In conclusion, we have adapted kinetic analyses to skin wound healing in rats, and found these analyses to be useful as an index of wound healing ability by a wound-healing drug. In addition, we show that treatment with the TS-combination ointment enhances the skin wound healing rate and reduces redness. These findings provide information significant to the search for new wound-healing therapies and for the design of wound-healing drugs.
  • Yamashiro, K.; Ogata, F.; Kawasaki, N.
    Yakugaku Zasshi PHARMACEUTICAL SOC JAPAN 137 (8) 1035 - 1040 0031-6903 2017 [Refereed]
     
    It is important to ingest just proportions of minerals to prevent disease, but these minerals are also secreted into the hair. Meanwhile, the number of hay fever patients in Japan is increasing, causing an increase in national medical expenses. In this study, we investigated the relationship between hay fever and mineral concentrations in hair to obtain findings on the risk of developing pollen allergies. A questionnaire survey was conducted for 275 men and 977 women on their lifestyle habits and ten kinds of mineral concentrations present in their hair were measured with subsequent analysis using nominal logistic regression analysis. The results indicated that half the patients in each age group had hay fever, with no significant difference between hay fever and aging, exercise habits, sleep and dietary rhythms. On the other hand, there was a significant difference between hay fever and mineral concentrations in the hair, and in men with hay fever, iron (odds ratio: 0.55, p<0.05) was low, while in women calcium (odds ratio: 0.67, p<0.05), chromium (odds ratio: 0.46, p<0.001), cadmium (odds ratio: 0.68, p<0.01) were low and selenium (odds ratio: 1.78, p<0.01) was high. These results, suggest that measurements mineral concentrations in hair are indicators of hay fever risk.
  • Ogata, F.; Ueta, E.; Toda, M.; Otani, M.; Kawasaki, N.
    Water Science and Technology IWA PUBLISHING 75 (1) 94 - 105 0273-1223 2017 [Refereed]
     
    Different molar ratios of a Ni/Co binary hydroxide (NiCo82, NiCo91, and Ni100) were prepared and calcined at 270 °C (NiCo82-270, NiCo91-270, and Ni100-270). The properties of the adsorbents and the amount of adsorbed phosphate ions were evaluated. The adsorbents calcined at 270 °C had a nickel oxide structure. The amount of adsorbed phosphate ions, the amount of hydroxyl groups, and the specific surface area of the calcined adsorbents at 270 °C were greater than those of the uncalcined adsorbents. The amount of adsorbed phosphate ions was related to the amount of hydroxyl groups and the specific surface area; the correlation coefficients were 0.966 and 0.953, respectively. The adsorption isotherm data for NiCo91 and NiCo91-270 were fit to both the Freundlich and Langmuir equations. The amount of adsorbed phosphate ions increased with increasing temperature. The experimental data fit the pseudo-second-order model better than the pseudo-first-order model. A neutral pH was optimal for phosphate ion adsorption. In addition, the phosphate ions that were adsorbed onto NiCo91-270 could be recovered using sodium hydroxide, and the adsorbent was useful for the repetitive adsorption/desorption of phosphate ions. Collectively, these results suggest that NiCo91-270 is prospectively useful for the adsorption of phosphate ions from aqueous solutions.
  • 基礎薬学分野の知識定着を志向した参加型学修システム構築の試み
    大内 秀一; 松野 純男; 和田 哲幸; 仲西 功; 前川 智弘; 多賀 惇; 伊藤 栄次; 大鳥 徹; 川崎 直人; 西田 升三
    日本薬学会年会要旨集 (公社)日本薬学会 136年会 (4) 218 - 218 0918-9823 2016/03
  • TSUZUKI HIROAKI; WATANABE NAOKO; OKAMURA KATSUMASA; YAMADA HIDEKAZU; YAMADA HIDEKAZU; OGATA FUMIHIKO; KAWASAKI NAOHITO; KAWASAKI NAOHITO
    Fragr J フレグランスジャーナル社 44 (1) 14 - 20 0288-9803 2016/01
  • Ogata, F.; Imai, D.; Toda, M.; Otani, M.; Kawasaki, N.
    Journal of Industrial and Engineering Chemistry ELSEVIER SCIENCE INC 34 172 - 179 1226-086X 2016 [Refereed]
     
    Nickel hydroxide (Ni) was calcined at 270 and 400 degrees C (denoted Ni270 and Ni400), and the properties of Ni, Ni270, and Ni400 were investigated. In addition, the phosphate adsorption capabilities of Ni, Ni270, and Ni400 were evaluated by examination of the effects of contact time and solution pH, analysis of an adsorption isotherm, and study of desorption. The amounts of phosphate ion adsorbed by the different samples showed the order Ni < Ni400 < Ni270. Finally, phosphate ions adsorbed onto Ni270 could be desorbed using sodium hydroxide, indicating that Ni270 can be used as a renewable adsorbent. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
  • Ogata, F.; Ueda, A.; Tanei, S.; Imai, D.; Kawasaki, N.
    Journal of Industrial and Engineering Chemistry ELSEVIER SCIENCE INC 35 287 - 294 1226-086X 2016 [Refereed]
     
    We investigated the simultaneous removal of phosphate and nitrite ions from aqueous solutions by a combination treatment that used both PG-Ca (polyl-gamma-glutamic acid combined with flocculating agents) and SB600 (soybeans treated with calcium chloride, hydrochloric acid and calcined at 600 degrees C). Phosphate ions and nitrite ions were selectivity adsorbed by PG-Ca and SB600, respectively. The removal mechanism of phosphate ions from aqueous solution was related to the presence of calcium hydroxide (derived from PG-Ca), and that of nitrite ions was related to the presence of chloride ions at the surface of SB600. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
  • Ogata, F.; Ueta, E.; Kawasaki, N.
    e-Journal of Surface Science and Nanotechnology 14 209 - 215 1348-0391 2016 [Refereed]
     
    © 2016 The Surface Science Society of Japan. In this study, pristine and calcined activated clay (AC) were characterized by scanning electron microscopy, X-ray diffraction analysis, thermogravimetric-differential thermal analysis, electron probe microanalysis, surface pH measurement, specific surface area measurement, and humidity adjustment. ACs were used as adsorbents for investigating the adsorption kinetics, isotherms, thermodynamic parameters, of Basic Red 46 (BR), Basic Blue 75 (BB), Acid Red 138 (AR), and Acid Blue 185 (AB) in aqueous solutions, as well as the effect of sodium hydroxide on these dyes. The results showed that adsorption of cationic and anionic dyes was related to the specific surface area (0.974-0.984) and humidity adjustment performance (0.939-1.000), respectively. The adsorption capacity of the cationic dyes (BB and BR) onto pristine AC increased on increasing the temperature. Equilibrium data using pristine AC fitted well to both the Langmuir and Freundlich isotherm models. Kinetic data were best described by the pseudo-second order model (correlation coefficient was 0.979-0.999 and 0.945-0.999 for BB and BR). Nearly 8 h of contact time was sufficient for the adsorption of cationic dyes to reach equilibrium. Thermodynamic parameters were also evaluated for the cationic dye-adsorbent system, which revealed that the adsorption process is endothermic in nature. These results demonstrated that pristine AC could be used as a natural adsorbent for the removal of cationic dyes (BB and BR) from aqueous solution.
  • Nagai, N.; Ogata, F.; Kawasaki, N.; Ito, Y.
    Biological and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 39 (1) 138 - 42 0918-6158 2016 [Refereed]
     
    Previous studies showed an increased prevalence of cataracts in postmenopausal women. In this study, we investigated changes in the levels of calcium ion (Ca(2+)) and interleukin (IL)-18, which are factors in cataract development, in the lenses of ovariectomized (OVX) rats, a model of postmenopausal woman. Although the Ca(2+) content in the blood of OVX rats increased 1 month after ovariectomy and subsequently decreased, the Ca(2+) content in the lenses was unchanged in OVX rats 1-3 months after ovariectomy. The Ca(2+)-ATPase activity in the lenses of OVX rats peaked 1 month after ovariectomy, and the behavior of Ca(2+)-ATPase activity in lenses of OVX rats was similar to that of the Ca(2+) concentration in the blood. It is possible that hypercalcemia increases the Ca(2+) inflow into the lens; however, the enhanced Ca(2+)-ATPase activity prevents the Ca(2+) level from rising. On the other hand, we found that the levels of both IL-18 and interferon (IFN)-γ in the lenses of OVX rats were significantly increased as compared with the lenses of sham (control) rats during the period 1-3 months after surgery. These results suggest that the expression of IFN-γ via IL-18 in the lenses of OVX rats is induced by ovariectomy, and that excessive IL-18 and IFN-γ production in the lenses may be related to cataract development in postmenopausal women. These findings support those of previous studies that assessed lens opacification in postmenopausal women.
  • Ogata, F.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 65 (11) 941 - 948 1345-8957 2016 [Refereed]
     
    In this study, we prepared virgin (S, L) and calcined (S-380, S-1000, L-380, L-1000) magnesium hydroxide for regeneration of waste edible oil. Deterioration of soybean oil, rapeseed oil, and olive oil was achieved by heat and aeration treatment. The properties of the different adsorbents were investigated using specific surface area measurements, scanning electron microscopy, X-ray diffraction analysis, thermogravimetric-differential thermal analysis, and surface pH measurement. Moreover, the relationship between the changes in acid value (AV) and carbonyl value (CV) and the adsorbent properties were evaluated. The specific surface areas of S-380 and L-380 were greater than that of other adsorbents. In addition, the XRD results show that S-380 and L-380 contain both magnesium hydroxide and magnesium oxide structures. The decreases in AV and CV using S-380 and L-380 were greater than achieved using other adsorbents. The correlation coefficients between the decrease in AV and CV and specific surface area were 0.947 for soybean oil, 0.649 for rapeseed oil, and 0.773 for olive oil, respectively. The results obtained in this study suggest that a physical property of the adsorbent, namely specific surface area, was primarily responsible for the observed decreases in AV and CV. Overall, the results suggest that S-380 and L-380 are useful for the regeneration of waste edible oil.
  • Ogata, F.; Imai, D.; Kawasaki, N.
    Journal of Environmental Chemical Engineering 3 (1) 155 - 161 2213-3437 2015 [Refereed]
     
    © 2014 Elsevier Ltd. All rights reserved. In this study, soybean (SB) was treated with calcium chloride, hydrochloric acid, and calcination (400, 600, 800, and 1000 °C) to introduce chloride ions onto the SB surfaces (SB400, SB600, SB800, and SB1000, respectively). The properties of the adsorbents (pH of the solution, acidic functional group, and basic functional group) were investigated. The adsorption of nitrate and nitrite ions onto SB surfaces at different temperatures was evaluated. SB600 had the highest concentration of acidic functional groups (3.34 mmol/g). The amount of nitrate and nitrite ions adsorbed onto SB600 in a binary solution system was lower than that in a single solution system. The amount of nitrate and nitrite ions adsorbed was closely related to the chloride ions. The adsorption mechanism of nitrate and nitrite ions onto SB600 mainly involved an ion exchange (correlation coefficient = 0.993). Moreover, chloride ions affected the adsorption process. The adsorption isotherm data using SB600 were fitted to both the Langmuir and Freundlich equations. The amount of nitrate and nitrite ions adsorbed increased with increasing temperature. The adsorption equilibriums of nitrate and nitrite ions onto SB600 were obtained after 24 and 16 h, respectively. The experimental data fit the pseudo-second-order model better than the pseudo-first-order model. Thus, SB600 is useful for the adsorption of nitrate and nitrite ions in a binary solution system.
  • Ogata, F.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 63 (12) 1040 - 6 0009-2363 2015 [Refereed]
     
    Morphological and chemical evaluation of Fe-Mg hydrotalcite (Fe-HT) was performed using scanning electron microscopy, X-ray diffraction analysis, and electron microanalysis for application as an adsorbent for water treatment. The adsorption of arsenic III (As(III)) on Fe-HT was evaluated via examination of the effect of the contact time and analysis of the adsorption isotherm. The amount of As(III) adsorbed increased slightly with increasing temperature. The results of the adsorption isotherm studies suggested that As(III) adsorption can be well described by both the Freundlich and Langmuir equations. The adsorption of As(III) on Fe-HT reached equilibrium within 24 h, and the adsorption kinetic data fit the pseudo-second-order kinetic model better than the pseudo-first-order model. The amount of As(III) present on the surface of Fe-HT increased after As(III) adsorption, and the crystalline structure of Fe-HT was maintained after adsorption of As(III). The (003) and (006) peaks in the X-ray diffraction patterns were attributed to basal reflections, and these peaks shifted from respective 2θ values of 10.86 and 21.94° to 11.12 and 22.52°, indicating exchange of As(III) with chloride ions in Fe-HT with consequent narrowing of the inter-layer spacing. Collectively, these results suggest that Fe-HT is prospectively useful for the adsorption of As(III) from aqueous solutions.
  • Nagai, N.; Ogata, F.; Kawasaki, N.; Ito, Y.; Funakami, Y.; Okamoto, N.; Shimomura, Y.
    Biological and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 38 (7) 1063 - 9 0918-6158 2015 [Refereed]
     
    Hypercalcemia is often observed in postmenopausal women as well as in patients with primary hyperparathyroidism or malignant tumors. In this study, we investigated the relationship between calcium ion (Ca(2+)) levels in lacrimal fluid and the rate of corneal wound healing in hypercalcemia using ovariectomized (OVX) rat debrided corneal epithelium. We also determined the effects of Ca(2+) levels on cell adhesion, proliferation and viability in a human cornea epithelial cell line (HCE-T). The calcium content in bones of OVX rats decreased after ovariectomy. Moreover, the Ca(2+) content in the blood of OVX rats was increased 1 month after ovariectomy, and decreased. The Ca(2+) content in the lacrimal fluid of OVX rats was also increased after ovariectomy, and then decreased similarly as in blood. Corneal wound healing in OVX rats was delayed in comparison with Sham rats (control rats), and a close relationship was observed between the Ca(2+) levels in lacrimal fluid and the rate of corneal wound healing in Sham and OVX rats (y=-0.7863x+8.785, R=0.78, n=25). In addition, an enhancement in Ca(2+) levels caused a decrease in the viability in HCE-T cells. It is possible that enhanced Ca(2+) levels in lacrimal fluid may cause a decrease in the viability of corneal epithelial cells, resulting in a delay in corneal wound healing. These findings provide significant information that can be used to design further studies aimed at reducing corneal damage of patients with hypercalcemia.
  • Ogata, F.; Tanaka, Y.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 63 (2) 187 - 91 1345-8957 2014 [Refereed]
     
    In this study, waste edible oil was prepared by both heat and aeration treatment, and the increasing inhibitive effect of tocopherol treatment on the acid value (AV) and carbonyl value (CV) of the oil was investigated. The AV and CV of waste edible oil treated with tocopherol were 0.1-1.0% lower than those of the nontreated oil, indicating that tocopherol exerted a radical-scavenging activity. The concentration of tocopherol decreased with time, while that of the remaining 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals increased. These results suggest that the addition of tocopherol proved to be useful for preventing the deterioration of waste edible oil.
  • Nishiwaki, K.; Kawase, A.; Wada, T.; Yagi, H.; Kawasaki, N.; Ito, E.; Iwaki, M.
    Yakugaku Zasshi PHARMACEUTICAL SOC JAPAN 134 (2) 171 - 7 0031-6903 2014 [Refereed]
     
    We conducted team-based learning (TBL) with interdisciplinary lectures as a part of "Introduction to Pharmacy", divided among the pharmacy department's six pharmacist education curricula in the first semester. The interdisciplinary lecture is led by seven lecturers, each specializing in one area: cell biology, biochemistry, chemistry, public health pharmacology, pharmacokinetics, and clinical science. This lecture's purpose is to demonstrate to the students that all field subjects relate to each other and they must learn the basic science subjects to understand pharmaceutical sciences. The TBL contents have two themes, "cancer" and "aspirin", each of which had two lectures, each 90 minutes long and were conducted using TBL as expansive learning. On receiving knowledge of a wide range of fields in one lecture, a small number of students indicated that they were unable to understand the contents very well. However, in the questionnaire about TBL, many students reported "I have understood" and "I have enjoyed studying" using TBL, especially group readiness assessment test (GRAT). By incorporating TBL, they reported "increasing eagerness to learn pharmacy". Overall, students seem to have accepted TBL favorably, but they still find peer review difficult. We believe that their discomfort with peer review results from their unfamiliarity in evaluating others, and the time before the evaluation is short because TBL is conducted only twice.
  • Ogata, F.; Kangawa, M.; Iwata, Y.; Ueda, A.; Tanaka, Y.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 62 (3) 247 - 53 0009-2363 2014 [Refereed]
     
    Raw wheat bran (R-WB) was used as a biomass adsorbent. The properties of R-WB were investigated. Moreover, the adsorption of cadmium and lead ions onto R-WB was evaluated. Adsorption equilibrium of cadmium and lead ions onto R-WB was achieved within 10 h, indicating that the adsorption followed a pseudo-second-order model rather than a pseudo-first-order kinetic model. The adsorption amount increased with increasing temperature. Correlation coefficient of the Langmuir equation is 0.999 for cadmium and 0.996 for lead ions, and that of the Freundlich equation is 0.994 for cadmium and 0.993 for lead ions. The negative ΔG value implied that the adsorption of cadmium and lead ions onto R-WB is a spontaneous process. The positive ΔS value indicated an increase in randomness at the solid-liquid interface. The optimal conditions for the adsorption column experiment were investigated (space velocity (SV) 2.2 1/h, linear velocity (LV) 0.1 m/h for cadmium; SV 6.51 1/h, LV 0.23 m/h for lead ions). Further, repeated adsorption-desorption of the cadmium and lead ions could be effected by using 0.01 mol/L HCl or 0.01 mol/L HNO3 solution. Consequently, polluted water could be successfully purified by using a column filled with this bioadsorbent.
  • Ogata, F.; Nagai, N.; Ito, Y.; Kawasaki, N.
    Yakugaku Zasshi PHARMACEUTICAL SOC JAPAN 134 (5) 679 - 85 0031-6903 2014 [Refereed]
     
    Since osteoporosis is a major public health problem in Japan, it is important to clarify the effect of high-mineral drinking water consumption on osteogenesis. Therefore, in this study, we investigated the relationship between high-mineral drinking water consumption and osteogenesis in ovariectomized rats that received a low-calcium diet and purified water (PW group) or a low-calcium diet and high-mineral drinking water (CR group). High-mineral drinking water affected the rats' body weight. After 3 months, the bone density of the CR group was higher than that of the PW group (p<0.05). Furthermore, the CR group showed a decrease in the amount of calcium in the bones after 3 months. These results suggest that high-mineral drinking water contributes to the maintenance of bone density and not to the amount of calcium in bone. On the other hand, serum alkaline phosphatase levels in the PW group at 3 months were higher than those in the CR group, which indicates that the blood concentration of calcium in the CR group was maintained. Moreover, the amount of magnesium in the bones and the blood concentration of magnesium in the CR group after 3 months were higher than the corresponding values in the PW group. These results suggest that consumption of high-mineral drinking water could be beneficial for osteogenesis (i.e., for maintaining bone quantity).
  • Ogata, F.; Ueda, A.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 62 (8) 799 - 805 0009-2363 2014 [Refereed]
     
    In this research, gibbsite (GB) samples calcined at 200-1000°C (GB200-GB1000) were produced. These GBs were used to adsorb orthophosphoric, pyrophosphoric, and tripolyphosphoric acids from aqueous solutions. The properties (amounts of hydroxyl groups, specific surface areas, mean pore diameters, and solution pHs) of the GBs were investigated, and their adsorption capacities for phosphoric acids evaluated. The amount of hydroxyl groups (0.46 mmol/g) and specific surface area (295.3 m(2)/g) of GB400 were greater than those of the other GBs. The mechanism of phosphoric acid adsorption on the GBs was related to the amount of hydroxyl groups and specific surface area. The optimal pH for phosphoric acid adsorption by GBs was 2.0-3.0. Equilibrium adsorption was reached within 24 h. The adsorption processes followed a pseudo-second-order kinetic model (correlation coefficient, 0.998-0.999). The adsorption capacity increased with increasing temperature. The adsorption isotherm data fitted the Langmuir (correlation coefficient: 0.921-0.992) and Freundlich (correlation coefficient: 0.948-0.997) equations well. Our results will be useful when developing methods for the adsorption of phosphoric acids from aqueous solutions.
  • Ogata, F.; Iwata, Y.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 62 (9) 892 - 7 0009-2363 2014 [Refereed]
     
    Fly ash (FA) was hydrothermally treated in an alkaline solution to produce zeolite fly ash (Z-FA). The properties of the FA and Z-FA were investigated. The amounts of tungsten (W) adsorbed onto the FA and Z-FA surfaces were evaluated. Z-FA was produced by hydrothermally treating FA in an alkaline solution. The specific surface area and pore volume of the Z-FA were greater than those of the FA. More W was adsorbed onto the Z-FA surface than onto the FA surface. The adsorption isotherms for W were fitted using both the Freundlich and Langmuir equations. The equilibrium concentrations of W adsorbed onto the FA and Z-FA surfaces were subsequently reached within 20 h. The pseudo-second-order model more accurately described the data than did the pseudo-first-order model. Sodium hydroxide solutions (1-50 mmol/L) were used to easily recover W from Z-FA, indicating that Z-FA was useful for recovering W from aqueous solutions.
  • NAGAI NORIAKI; OGATA FUMIHIKO; FUNAKAMI YOSHINORI; ITO YOSHIMASA; KAWASAKI NAOHITO
    あたらしい眼科 メディカル葵出版 30 (11) 1623 - 1627 0910-1810 2013/11 
    加齢に伴う全身性機能の変化が視覚(眼領域)へ及ぼす影響を明確にすることは、超高齢化社会を迎えるわが国において非常に重要である。本研究では、閉経後のカルシウム不足と角膜上皮傷害の自己修復機能の関係を明らかとすべく、卵巣摘出ラットへの低カルシウム食投与時における角膜上皮傷害治癒速度について検討を行った。1ヵ月間の低カルシウム食(低カルシウム飼料および精製水)投与は体重、飼料摂取量および飲水量に影響を与えなかったが、血中および骨中カルシウム量の低下がみられた。また、これらカルシウム欠乏ラットの角膜上皮を剥離し、一次速度式にて角膜傷害治癒速度定数を算出したところ、正常ラットと比較し、角膜傷害治癒速度定数が有意に低値を示した。以上、本研究では卵巣摘出モデルを用いたin vivo実験において、低カルシウム食摂取時には角膜傷害治癒速度が低下することを明らかとした。(著者抄録)
  • Naohito Kawasaki; Hisato Tominaga; Fumihiko Ogata
    SEN-I GAKKAISHI SOC FIBER SCIENCE TECHNOLOGY 69 (7) 125 - 131 0037-9875 2013/07 [Refereed]
     
    The methylene blue and dyestuff removal efficiency in a textile factory by ozonation and/or carbonaceous material treatment was investigated. Three kinds of carbonaceous materials were prepared from wool (WL), polyester (PET), and cotton (CT) discharged from the textile factory. The physical properties of the carbonaceous materials were very different. The specific surface area and pore volume of WL were the lowest, while those of CT were the highest. The dyestuff removal efficiency from actual dyestuff water was the highest when using the carbonaceous material (CT) prepared from cotton waste fiber. The decreases in the chromaticity, turbidity, COD, and TOC of the actual dyestuff wastewater depended upon the mean pore diameter of the carbonaceous material. The COD and TOC of the actual dyestuff wastewater were only slightly decreased by ozonation. The ozonation with CT would be useful for the removal of the dyestuff from actual textile wastewater. These results indicated that the waste cotton fiber could be converted into a carbonaceous material as an adsorbent for the removal of dyestuff from actual wastewater.
  • TOMINAGA HISATO; SAGAWA KAZUNORI; OGATA FUMIHIKO; KAWASAKI NAOHITO; KAWASAKI NAOHITO
    保健医療学雑誌(Web) 保健医療学学会 4 (1) 9-16 (WEB ONLY) - 16 2185-0399 2013/04 
    2011年に生涯スポーツ講義を受講した男子学生2198名、女子学生794名(平均18.6歳)を対象に、体力測定と生活習慣・心身の健康状態に関するアンケート調査を行い、その関連性について検討した。その結果、学生の体力項目の測定値は、男女とも背筋力を除きほぼ全国水準であった。男子学生では朝食摂取していない割合が、女子学生に比べ有意に高かった。また、各生活習慣に関する指標について男女別で比較すると、男子学生は女子学生に比べ身体的状態が高く、精神的状態はPositive思考であった。食習慣、睡眠習慣、運動習慣の満足度については、男子学生で有意に高値を示し、生活習慣および心身の健康状態の自己評価は男子学生の方が高かった。体力との関連では、男子学生は身体的状態、精神的状態、運動習慣との間に、女子学生は身体的状態との間に有意な相関関係が示された。
  • Ogata, F.; Tanaka, Y.; Tominaga, H.; Kangawa, M.; Inoue, K.; Ueda, A.; Iwata, Y.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 62 (2) 109 - 14 1345-8957 2013 [Refereed]
     
    This study investigated the regeneration of waste edible oil using a food additive (calcium silicate, CAS). Waste edible oil was prepared by combined heat and aeration treatment. Moreover, the deterioration of edible oil by combined heat and aeration treatment was greater than that by heat treatment alone. The acid value (AV) and carbonyl value (CV) increased with increasing deterioration; conversely, the tocopherol concentration decreased with increasing deterioration. The specific surface area, pore volume, and mean pore diameter of the 3 CAS formulations used (CAS30, CAS60, and CAS90) were evaluated, and scanning electron microscopic images were taken. The specific surface area increased in the order of CAS30 (115.54 m(2)/g) < CAS60 (163.93 m(2)/g) < CAS90 (187.47 m(2)/g). The mean pore diameter increased in the order of CAS90 (170.59 Å) < CAS60 (211.60 Å) < CAS30 (249.70 Å). The regeneration of waste edible oil was possible with CAS treatment. The AV reduced by 15.2%, 10.8%, and 23.1% by CAS30, CAS60, and CAS90 treatment, respectively, and the CV was reduced by 35.6%, 29.8%, and 31.3% by these 3 treatments, respectively. Moreover, the concentrations of tocopherol and free fatty acids did not change with CAS treatment. The characteristics of CAS were not related to the degree of change of AV and CV. However, the adsorption mechanism of polar and non-polar compounds generated in waste edible oil by CAS was related with the presence of silica gel molecules in CAS. The findings indicated that CAS was useful for the regeneration of waste edible oil.
  • Ogata, F.; Tominaga, H.; Ueda, A.; Tanaka, Y.; Iwata, Y.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 62 (4) 241 - 4 1345-8957 2013 [Refereed]
     
    This study investigated the removal of free residual chlorine by activated carbon (AC). ACs were prepared from coal (AC1) and coconut shell (AC2). The specific surface area of AC1 was larger than that of AC2. The removal of free residual chlorine increased with elapsed time and amount of adsorbent. The removal mechanism of free residual chlorine was the dechlorination reaction between hypochlorous acid or hypochlorite ion and AC. Moreover, AC1 was useful in the removal of free residual chlorine in tap water. The optimum condition for the removal of free residual chlorine using a column is space velocity 306 1/h; liner velocity 6.1 m/h.
  • Ogata, F.; Ueda, A.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin 61 (10) 1030 - 6 0009-2363 2013 [Refereed]
     
    We investigated a method for producing granulated boehmite (BE) by using an organic binder and measured its phosphate-ion-adsorption capacity. BE was granulated using polyethylene terephthalate (PET), and its structure was characterized by scanning electron microscopy and X-ray diffraction analyses. The properties of granulated BE such as specific surface area, mean pore diameter, pore volume, amount of hydroxyl groups, and solution pH were also investigated. Furthermore, adsorption isotherm; effects of contact time, temperature, and solution pH on phosphate-ion adsorption; and recovery of phosphate ions (using sodium hydroxide solution) were evaluated. BE granulated by PET (BE-PET30S) could be successfully used for phosphate-ion removal by adsorption. The specific surface area and amount of hydroxyl groups of BE-PET30S were found to be 119.8 m²/g and 1.4 mmol/g, respectively. Granulated BEs reached equilibrium adsorption capacities within 24 h. The phosphate-ion-adsorption rate data were fitted to the pseudo-second-order kinetic model (r=0.981-0.998). The adsorption isotherm data were fitted to both the Freundlich (0.987-0.989) and Langmuir (0.905-0.944) equations. Based on the thermodynamic study, it was found that the phosphate-ion adsorption by granulated BEs is a spontaneous and exothermic process. The phosphate ions adsorbed onto BE-PET30S could be easily recovered by using a sodium hydroxide solution (1-1000 mmol/L) and their recovery percentage was found to be between 63.3% and 94.0%. The results obtained from this study could be useful for recovering phosphate ions and preventing problems related to water pollution.
  • Ogata, F.; Kangawa, M.; Tominaga, H.; Tanaka, Y.; Ueda, A.; Iwata, Y.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 62 (11) 949 - 53 1345-8957 2013 [Refereed]
     
    In this study, raw wheat bran (R-WB), a type of waste biomass (WB) was treated with Pectinase PL (P-WB), and the properties (yield percentage, carboxy group surface concentration, the solution pH, and specific surface area) of R-WB and P-WB were investigated. The surface concentration of carboxy groups on R-WB (3.56 mmol/g) was greater than that of P-WB (2.11 mmol/g). In contrast, the specific surface area of P-WB (24.98 m²/g) was greater than that of R-WB (3.25 m²/g). In addition, the adsorption of cadmium and lead ions to WB was evaluated. Adsorption of the heavy-metal ions reached equilibrium within 9 h, and the experimental data was fitted to a pseudo-second-order model. More heavy-metal ions were adsorbed onto R-WB than onto P-WB. The correlation coefficient between the amount of ions adsorbed and the number of carboxy groups or pectin exceeded 0.884 and 0.975, respectively. This study indicated that wheat bran was useful for the removal of cadmium or lead ions from aqueous solutions. The adsorption mechanism of cadmium and lead ions to WB was associated with presence of carboxy group in pectin.
  • Ogata, F.; Tominaga, H.; Kangawa, M.; Inoue, K.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 61 (3) 149 - 54 1345-8957 2012 [Refereed]
     
    The potential utility of the widely available waste product, wool textiles, in the adsorption of heavy metals from industrial and other wastewater systems was investigated by proxy experimentation. Carbon fiber was prepared from dyed wool (DW) by calcination at different temperatures (400, 600, 800, and 1000 °C, referred to as DW400, DW600, DW800, and DW1000, respectively). The samples were analyzed in terms of scanning electron microscope images, percentage yield, specific surface area, pore volume, and the pH of an aqueous suspension of virgin dyed wool (V-DW) or the calcined DW. The adsorption of Cu(II) and Pb(II) from aqueous solutions was studied using the batch method, and the effect of contact time and co-existence of metal ions was investigated. Cu(II) and Pb(II) adsorption increased with increasing DW calcination temperature in the order V-DW < DW400 < DW600 < DW800 < DW1000. The maximum equilibrium adsorption of Cu (II) and Pb(II) achieved with DW1000 (79% and 57%, respectively) was reached within 6 h. Fitting of the adsorption isotherm data for Cu(II) and Pb(II) adsorption onto DW1000 to the Freundlich equation was consistent with monomolecular adsorption onto a heterogeneous surface. The rate-limiting step was determined to be chemical sorption by fitting the adsorption kinetics data to pseudo first-order and pseudo second-order models, given that the pseudo second-order model best fit our data. The study demonstrated that DW1000 was useful for purification of wastewater containing Cu(II) and Pb(II).
  • Ogata, F.; Tominaga, H.; Kangawa, M.; Inoue, K.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 61 (4) 217 - 25 1345-8957 2012 [Refereed]
     
    This study investigates the activated carbon (AC) treatment and ozone oxidation of the sulfa drugs--sulfamethoxazole (SMX), sulfamonomethoxine (SMM), sulfadimidine (SDD), and sulfadimethoxine (SDM)--in aqueous solution systems. Three AC samples were prepared from Shirasagi (AC1 and AC2) and coal (AC3), and the surface functional groups, solution pH, specific surface areas, pore volumes, and morphologies of the three samples were evaluated. The specific surface areas were in the following order: AC1 (1391 m²/g) > AC2 (1053 m²/g) > AC3 (807 m²/g). The pore volume and mean pore diameter of AC3 were greater than those of AC1 and AC2. The concentration of sulfa drugs adsorbed onto the AC samples reached equilibrium within 150 h. Experimental data of the adsorption rate were fitted to a pseudo-second-order model. The amount of sulfa drugs adsorbed onto the AC samples was in the order of SDM < SMM < SDD < SMX; the mechanism of adsorption of the sulfa drugs onto the AC samples depended on the hydrophobicity of the AC surface. The adsorption isotherm data were fitted to Freundlich and Langmuir models. Ozone was generated from oxygen gas using an A-27 ozone generator, and the complete degradation of the sulfa drugs by ozone treatment at 60 mL/min was achieved within 50 min. Ozone treatment caused the structure of the sulfa drugs to decompose via ozone oxidation.
  • Ogata, F.; Tominaga, H.; Kangawa, M.; Inoue, K.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 60 (8) 985 - 8 0009-2363 2012 [Refereed]
     
    In this study, we investigated the surface properties of granulated boehmite with vinyl acetate (G-BE20) and measured the amount of phosphate it adsorbed and the effect of contact time and solution pH on the adsorption process. The specific surface area (144.9 m(2)/g) and the number of surface hydroxyl groups (0.88 mmol/g) of G-BE20 were smaller than those of virgin boehmite (BE), which gave a specific surface area and number of surface hydroxyl groups of 297.0 m(2)/g and 1.08 mmol/g, respectively. The amount of phosphate adsorbed increased with the temperature. The isotherm model of Langmuir was used to fit experimental adsorption equilibrium data for phosphate adsorption onto G-BE20. The calculated thermodynamic parameters show the spontaneous and endothermic nature of the adsorption process. The equilibrium adsorption onto G-BE20 was reached within 16 h and the amount of phosphate adsorbed was 8.4 mg/g. The kinetic mechanism of phosphate uptake was evaluated with two different models: the Largergren pseudo first- and pseudo second-order models. The data obtained showed a better fit to the pseudo second-order model (0.991) than to the pseudo first-order model (0.967), as indicated by the r values. The rate constants for the adsorption of phosphate onto G-BE20 were calculated as 0.481 1/h and 0.029 g/mg h. The adsorption of phosphate onto G-BE20 was the maximum in the pH range 3.0-4.0.
  • Kawasaki, N.; Tominaga, H.; Ogata, F.; Inoue, K.; Kankawa, M.
    Journal of Oleo Science Japan Oil Chemists' Society 61 (10) 593 - 600 1345-8957 2012 
    The volume of waste fiber has increased rapidly in recent years, and this trend is expected to continue. In this study, therefore, we attempted to convert waste fiber to carbonaceous materials by carbonization and investigated the basic properties of the resulting carbonized fibers. The results demonstrated that pores tend to form and specific surface areas change substantially, depending on the carbonization conditions. The carbonization conditions resulting in the largest specific surface areas included a temperature increase and retention times of 2 h. Carbonization temperatures resulting in the maximum values of 1000°C were 900-1000°C for wool and 1000°C for both polyester and cotton. In particular, the specific surface area of cotton after carbonization at 1000°C was 1253 m²/g, and scanning electron microscopy (SEM) micrographs showed that cotton retained its fibrous form after carbonization. Thus, it is possible to inexpensively convert waste fibers to carbonaceous material by carbonization. The results indicate that for cotton fiber in particular, the practical application of this process to the production of low-cost fibrous activated carbon would be possible, since cotton fiber retains its fibrous form under carbonization.
  • Ogata, F.; Tominaga, H.; Yabutani, H.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 60 (3) 133 - 8 1345-8957 2011 [Refereed]
     
    In the present study, the phosphate adsorption abilities of granular materials, gibbsite (GB) and cerium hydroxide (CE), granulated with ethyl cellulose and ethanol, were investigated. For suitable granular conditions using GB or CE, the percentage of binder and amount of solvent were 10% and 3.25 mL/5 g for GB and 7.5% and 2.50 mL/5 g for CE. The amount of phosphate adsorbed by granular GB or CE was similar to that adsorbed by powdered GB or CE. The adsorption isotherms of phosphate were also similar for the granular and powdered materials. The results of a column experiment showed that when GB was used, the suitable concentration of sodium hydroxide as the desorption solution was 2 mmol/L. In these experiments, the amount of phosphate adsorbed was 31.4 mg/g, the amount of phosphate desorbed was 25.3 mg/g, and the recovery percentage was 80.5%. In contrast, when CE was used, the suitable concentration of sodium hydroxide was 500 mmol/L; the amount of phosphate adsorbed was 77.7 mg/g, the amount of phosphate desorbed was 57.8 mg/g, and the recovery percentage was 74.4%. Results also indicate that granular GB and CE could be used at least five times in a column without loss of absorption or desorption abilities. Moreover, granulation of GB and CE is possible using ethyl cellulose and ethanol.
  • Ogata, F.; Tominaga, H.; Kangawa, M.; Kawasaki, N.
    Chemical and Pharmaceutical Bulletin PHARMACEUTICAL SOC JAPAN 59 (11) 1400 - 2 0009-2363 2011 [Refereed]
     
    In this study, we investigated the surface properties of raw wheat bran (R-WB) and wheat bran treated with Pectinase PL (P-WB) to evaluating its efficacy for removal of cadmium from waste water. The concentration of cadmium ions adsorbed by them was evaluated. The concentration of carboxyl groups of R-WB (3.56 mmol/g) was greater than that of P-WB (2.11 mmol/g), which indicated that the pectin of R-WB was broken down, resulting in a decrease in the concentration of carboxyl groups due to the enzyme treatment. From the scanning electron microscope (SEM) images of P-WB, the pores were newly generated with enzyme treatment. The concentration of cadmium ions adsorbed onto R-WB was greater than that of cadmium ions adsorbed onto P-WB. These results show that the adsorption mechanism of cadmium ions onto R-WB and P-WB depends on the carboxyl groups of pectin.
  • Ogata, F.; Tominaga, H.; Yabutani, H.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 60 (12) 609 - 11 1345-8957 2011 [Refereed]
     
    Estrogens (estron: E1; estradiol: E2; estriol: E3) are major water pollutants. For the removal of estrogens, activated carbon (AC) and ozone treatments were employed, and the chemical oxygen demand (COD) and pH of a single solution and multiple solution systems were investigated. The removal of estrogens increased with the amount of AC. The percentage of removed estrogens by AC in the single solution system was greater than that in the ternary solution system. The estrogens were completely removed using ozone, which also reduced COD and pH. The removal of estrogens increased the water quality and decreased the amount of organic carbon.
  • Ogata, F.; Tominaga, H.; Yabutani, H.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 60 (12) 619 - 25 1345-8957 2011 [Refereed]
     
    Carbonaceous material for the removal of fluoride ions from water was prepared from coffee grounds (CGs) by calcination and subsequent HCl treatment. The characteristics of the CGs, including the surface area, mean pore diameter, pore volume, and surface functional groups were determined, and the morphological characteristics were evaluated using scanning electron microscopy. The adsorption isotherms, saturated amount of fluoride ions adsorbed, and the effect of contact time and temperature on the adsorption of fluoride ions were investigated for a sample of tap water. The specific surface area of CG calcined at 600° (CG600) was larger than that of CGs calcined at 400, 800, and 1000°. Phenolic, lactonic, and carboxyl groups were detected on the CG600 surface. The adsorption capacity of the carbonized CGs for fluoride was ranked in the order CG400 < CG1000 < CG800 < CG600 (where the numeral indicates the carbonization temperature), whereas virgin CG and CG600-NAT (not treated with hydrochloric acid solution) did not exhibit any adsorption ability for fluoride ions. The amount of fluoride ions adsorbed onto CG600 increased with increasing temperature and was consistent with chemical adsorption. The mechanism of adsorption of fluoride ions onto CG600 proceeded via ion exchange with chloride ions (1:1) present on the surface of CG600. The adsorption isotherms were fitted to the Freundlich and Langmuir equations. Moreover, CG600 showed an acceptable adsorption capacity for fluoride ions present in tap water.
  • Ogata, F.; Tominaga, H.; Yabutani, H.; Taga, A.; Kawasaki, N.
    Toxicological and Environmental Chemistry TAYLOR & FRANCIS LTD 93 (4) 635 - 642 0277-2248 2011 [Refereed]
     
    The effectiveness of gibbsite (GB), an amorphous aluminum oxide, for the recovery of Mo(VI) from eluates of fly ash of two coal-fired thermal power stations and of roof tile waste was investigated. Upon the qualitative analysis of an eluate of fly ash, 16 elements were detected. Greater amounts of these elements were eluted under acidic conditions (pH 2) than from the neutral or basic eluate of fly ash. GB was used for the adsorption of Mo(VI). Equilibrium adsorption was reached within 1 min. Optimal solution acidity for the adsorption of Mo(VI) onto GB400 (calcined at 400 degrees C) was pH 2. The main adsorption mechanism was ion exchange with a number of hydroxyl groups of GB400. For repeated ad- and desorption of Mo(VI), GB400 could be used at least four times and the recovery percentage of Mo(VI) with sodium hydroxide solution as eluent surpassed 90%. Our results showed that GB400 was very effective for the recovery of Mo(VI) from fly ash.
  • Ogata, F.; Tominaga, H.; Yabutani, H.; Kawasaki, N.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 60 (7) 363 - 8 1345-8957 2011 [Refereed]
     
    In this study, the amount of copper or cadmium adsorbed using waste biomass (i.e., coffee grounds (CG) and rice bran (RB)) was investigated. The amount of crude protein in defatted CG (D-CG) or RB (D-RB) was greater than that in CG or RB, respectively. The amount of copper or cadmium adsorbed using CG was greater than that using RB. Additionally, the amount of copper or cadmium adsorbed was not affected by the presence of fat in CG. Adsorption data was fitted to the Freundlich equation, and the correlation coefficients were in the range of 0.794-0.991. The main adsorption mechanism was thought to be monolayer adsorption onto the surface of the waste biomass. The adsorption rate data was fitted to the pseudo-second-order model, and the correlation coefficient average was in the range of 0.891-0.945. This result showed that the rate-limiting step may be chemisorption. Moreover, the amount of copper or cadmium desorbed from CG or RB using 0.01 mol/L or 1.00 mol/L HNO(3) was investigated. Desorption with 0.01 mol/L HNO(3) resulted in the recovery of 86-97% of the copper and cadmium, indicating that copper or cadmium that was adsorbed using waste biomass was recoverable.
  • Tomohisa Yasuhara; Naohito Kawasaki; Hideki Yagi; Eiji Itoh; Atsushi Kawase; Toru Otori; Tetsuyuki Wada; Kenji Matsuyama; Masahiro Iwaki
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan PHARMACEUTICAL SOC JAPAN 130 (12) 1647 - 53 0031-6903 2010/12 [Refereed]
     
    The six-year pharmacist education course has begun, and now first-year students receive clinical training. Interdisciplinary problem-solving capabilities covering chemistry, biology, molecular biology, pharmacology, pathology, and pharmacokinetics are necessary for new pharmacists. However, the conventional pharmaceutical science education was so separate from other fields that education for interdisciplinary cooperative capability was insufficient. This was especially true of elemental science courses, because they are not directly connected with clinical knowledge, and there is a problem of low student interest in those courses. As a result, students acquired only recall-level knowledge in clinical courses and their problem-solving capabilities in clinical treatment and drug development deteriorated. Therefore we offered a trial lecture aimed to help students recognize the important relationship between elemental science courses and clinical courses and increase their motivation to enroll in these courses. Specifically, the trial lecture covered cancer therapy, in reference to mechanisms of carcinogenesis, epidemiology, physiology of cancer, anticancer drugs with explanations of the mechanism of action of carcinogens, anticancer drugs, and molecular-targeted drugs from the viewpoints of organic chemistry and biochemistry by a specialized teacher. This paper reports on this experimental lecture with evaluations from students.
  • OGATA Fumihiko; YABUTANI Hitoshi; TOMINAGA Hisato; YAMAGUCHI Isao; KAWASAKI Naohito
    KAGAKU KOGAKU RONBUNSHU The Society of Chemical Engineers, Japan 36 (3) 293 - 298 0386-216X 2010/07 
    To investigate the recycling of coffee grounds (CGs), the surfaces of CGs were modified with CaCl2 solution, and the adsorption mechanism of NO3−-N and NO2−-N on these surfaces was evaluated. Maximun adsorption of NO3−-N and NO2−-N was observed with CGs carbonized at 600°C (CG600), and the amounts adsorbed increased with temperature, at the time of adsorption, reaching equilibrium after 24 h. The amount of chloride ions eluted from CG600 increased with the amount of NO3−-N and NO2−-N adsorbed. The adsorption isotherms of NO3−-N and NO2−-N were fitted by the Freundlich and the Langmuir equations. These results indicated that NO3−-N and NO2−-N were adsorbed onto CG600 by ion exchange. CGs treated with CaCl2 solution can be utilized for the removal of NO3−-N and NO2−-N from drinking water.
  • Naohito Kawasaki; Hisato Tominaga; Fumihiko Ogata; Kazuaki Kakehi
    CHEMICAL ENGINEERING JOURNAL ELSEVIER SCIENCE SA 157 (1) 249 - 253 1385-8947 2010/02 
    Food waste is discharged abundantly, and while some of it is reused, most is incinerated. The recycling of soybean waste and wheat bran as vegetable biomass needs to become established, and the ability to remove Cd(2+) and Cu(2+) by vegetable biomass needs to be estimated. The estimations performed here revealed that the amounts of Cd(2+) and Cu(2+) adsorbed onto untreated vegetable biomass were larger than those adsorbed onto defatted biomass. This indicates that the adsorption of Cd(2+) and Cu(2+) onto vegetable biomass may depend on fat content. On the other hand, the elution percentage of vegetable biomass increased as the concentration of hydrochloric acid increased. The elution is due to the degradation of protein in the biomass by the acid. The amounts of Cd(2+) and Cu(2+) adsorbed decreased as more than 0.10 mol/L of the concentration of hydrochloric acid increased. Cd(2+) and Cu(2+) are adsorbed on vegetable biomass by their adsorption onto protein. The amounts of Cu(2+) adsorbed onto soybean waste and wheat bran in a binary-solution system are larger than those in a single-solution system. However, less Cd(2+) was adsorbed onto wheat bran in the binary system than in the single one. These results indicated that the amount of Cu(2+) adsorbed increases in the presence of Cd(2+). Either the adsorption of Cd(2+) onto wheat bran is inhibited by Cu(2+) or the adsorptions of Cd(2+) and Cu(2+) onto the biomass were affected by each other. (C) 2009 Elsevier B. V. All rights reserved.
  • Ogata Fumihiko; Kawasaki Naohito; Hayashi Tomonori; Nishiura Saori; Matsuoka Hiroshi; Tachibana Sadanobu; Kakehi Kazuaki
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Japanese Society of Pharmaceutical Health Care and Sciences 36 (12) 874 - 879 1346-342X 2010 
    In the present study,we examined whether distilled water or tap water affects the release of the major component from the tablet in the simple suspension method.We first analyzed hospital tap water for the presence of 22 different elements and 11 of them (B,Na,Mg,Ca,Ni,Fe,Cu,Zn,Ba,Mn and Cd) were detected.However,the concentrations of all these elements were below the limits prescribed by the water quality standards for drinking water specified in the Waterworks Law of Japan.We then studied the release of amlodipine besilate from the originator product containing it as the active ingredient and 5 generic versions using the simple suspension method.The amlodipine contents of the originator product and generics were 98.2-101.7%,within the range specified in the Japanese Pharmacopoeia.After suspending in distilled water for 30 and 120 min,the amounts of amlodipine released from the originator drug were 15 and 38%,respectively.Those for generics at 30 and 120 min were similar to the originator except for one generic which was designed to release the active ingredient in the mouth.In conclusion,for the simple suspension method,the amounts of amlodipine released from originator drug with time into water were similar to those for generics.
  • Kawasaki, N.; Ogata, F.; Tominaga, H.
    Journal of Hazardous Materials ELSEVIER SCIENCE BV 181 (1-3) 574 - 9 0304-3894 2010 [Refereed]
     
    The specific surface area and X-ray diffraction patterns for an aluminum hydroxide gel (AHG) calcined at 300-1150 degrees C, the number of surface hydroxyl groups in the AHG, and the adsorption isotherms of phosphate on AHG were measured in order to develop a phosphate recovery agent. AHG was transformed into gamma- and alpha-alumina by the calcinations treatment. The amount of phosphate adsorbed onto AHG increases at calcining temperatures of 300-700 degrees C and decreases above a calcining temperature of 800 degrees C. It was found that AHG selectively adsorbs phosphate ions, but not other anions, and shows the highest adsorption capacity at pH 4-6. Further, the alkali resistance of AHG increased with calcination, and more than 80% of the phosphate adsorbed with an NaOH aqueous solution underwent desorption. The addition of colloidal alumina and colloidal silica resulted in the formation of granules of 500-840 microm size. The amount of phosphate adsorbed onto AHG after granulation was similar to that before granulation. Thus, the phosphate absorption capacity of AHG did not decrease after granulation suggesting that AHG can be used as a phosphate adsorbent.
  • Burapadaja, S.; Kawasaki, N.; Charumanee, S.
    International Journal of Risk and Safety in Medicine 22 (1) 17 - 25 0924-6479 2010 
    Safety is one of the very important elements of medicines, especially in daily practice. It is expected that the medicines listed by the Thai Essential Medicine Lists (EML) and their market products registered by the Thai Food and Drug Administration (FDA) should be comparable with respect to practical safety. The objective was to investigate if there are differences in practical safety between anti-infective essential medicines and their products assigned by the two authorities in Thailand. Data were based on Thai EML, Thai FDA registration, and Thailand Index of Medical Specialities 2008. Results showed that Thai EML and Thai FDA divided anti-infective items (n = 101) and their products into groups varying in practical safety. Two thirds of the items and their products were comparable with respect to practical safety, but one third of them were not. The products of the latter were defined as having a lower practical safety compared to their corresponding items. This study has demonstrated that there are differences in practical safety between several essential medicines and their products. Consistent practical safety is very necessary for safe use of anti-infective products. Thus, there should be deliberations between the two authorities to reconsider the practical safety of these items and their products. © 2010 - IOS Press and the authors. All rights reserved.
  • Ogata, F.; Takahashi, K.; Tominaga, H.; Yabutani, H.; Kawasaki, N.
    e-Journal of Surface Science and Nanotechnology 8 258 - 260 1348-0391 2010 
    This study investigated the ability of cerium hydroxide (CE) to adsorb phosphate, and compared it to the aluminum compounds boehmite (BE) and gibbsite (GB), which possess high phosphate adsorption ability. Speci c surface area, number of hydroxyl groups, and amount of phosphate adsorbed were measured. Results indicated that speci c surface area increased in the order GB < CE < BE, number of hydroxyl groups increased GB < BE < CE, and amount of phosphate adsorbed increased GB < BE < CE. These results showed that the adsorption mechanism of phosphate using CE was more closely related to chemical factors involved in the exchange of phosphate with hydroxyl groups onto CE than to physical factors such as speci c surface area. © 2010 The Surface Science Society of Japan.
  • 川崎 直人; 高島 規郎; 佐川 和則; 山田 秀和; 新藤 勝久; 掛樋 一晃
    薬学雑誌 (公社)日本薬学会 129 (8) 965 - 974 0031-6903 2009/08 
    大学内特定健診における腹囲測定とメタボリックシンドロームとの関連性について検討した。血液検査を受けた教職員、男性449例、女性183例の結果を用いた。50歳代及び60歳代の男性の腹囲は有意差を認めなかったが40歳代の男性に比べて高い値となった。各年齢代別の収縮期血圧は加齢に伴い有意に上昇した。高中性脂肪血症の男性は449例中130例で、中性脂肪を低下させるための食習慣や運動習慣など生活習慣改善に関する介入の必要性が明らかになった。50歳代及び60歳代の女性の腹囲の値は男性の結果と同様に、40歳代の女性に比べて高い値となり、加齢に伴い有意に増大した。中性脂肪に関しては、高中性脂肪血症の女性は183例中67例となり有病率は男性に比べ高い値を示した。腹囲が増大するほど、高血圧、高中性脂肪血症、低HDL-コレステロール血症、高血糖になりやすいことが明らかとなった。
  • OGATA Fumihiko; KAWASAKI Naohito; KABAYAMA Mineaki; KAKEHI Kazuaki
    KAGAKU KOGAKU RONBUNSHU The Society of Chemical Engineers, Japan 35 (1) 42 - 46 0386-216X 2009/03 
    Arsenic (III) and chromium (VI) are known to be harmful for human health. In this study, gibbsite (GB) was granulated using ethyl cellulose or alumina sol 520 for the removal of arsenic (III) and chromium (VI) . Two kinds of granular GBs had the ability to adsorb arsenic (III) and chromium (VI), with arsenic (III) being adsorbed in greater amount. Use of ethyl cellulose to prepare granular GB may not be economically suitable, because the production process is complex and requires the use of solvent. The amount of arsenic (III) and chromium (VI) adsorbed onto GB was slightly decreased by the granulation. The amount of arsenic (III) adsorbed onto granular GB in a binary solution system was greater than that in single solution system, while the amount of chromium (VI) adsorbed was similar in both systems. The adsorption mechanism of arsenic (III) and chromium (VI) is thought to dependent on the affinity between the metals and the surface or porosity of granular GB. The prepared GB could be utilized for removal of arsenic (III) or chromium (VI) in an aqueous environment.
  • 特定健診における腹囲と血液検査との関連性に関する統計解析
    川崎 直人; 村上 悦子; 高島 規郎; 山田 秀和; 掛樋 一晃
    日本薬学会年会要旨集 (公社)日本薬学会 129年会 (3) 276 - 276 0918-9823 2009/03
  • Ogata, F.; Kawasaki, N.; Kabayama, M.; Kakehi, K.
    Chemical and Pharmaceutical Bulletin The Pharmaceutical Society of Japan 57 (2) 129 - 33 0009-2363 2009 
    The adsorption properties of As(III) and Cr(VI) by gibbsite (GB) calcined at 200 to 1150 degrees C was investigated on basis of their specific surface area, number of hydroxyl groups, surface pH and adsorption isotherms. The amount of As(III) and Cr(VI) adsorbed on the calcined GB at 300 or 400 degrees C was the highest. In the case of the calcination temperature was more than 700 degrees C, the amount adsorbed decreased with the increasing calcination temperature. In a single solution system, the amount of As(III) adsorbed on calcined GB was higher than that of Cr(VI). The amount of As(III) and Cr(VI) adsorbed on calcined GB was higher in a binary solution system than those in a single solution system. The pH in solution after As(III) and Cr(VI) adsorption was greater than that before adsorption. These results indicated that the adsorption mechanism of As(III) and Cr(VI) was as followed: the hydroxyl groups on calcined GB were exchanged to As(III) and Cr(VI) and they adsorbed n the calcined GB surface. In the case of coexistence of As(III) and Cr(VI), they could be removed better by calcined GB because the pH in binary solution was lower than that in single solution. Both As(III) and Cr(VI) in water environment could be removed by the calcined GB simultaneously.
  • Kawasaki, N.; Ogata, F.; Yamaguchi, I.; Tominaga, H.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 58 (5) 261 - 6 1345-8957 2009 [Refereed]
     
    The present study investigates (1) ozone treatment, (2) adsorption treatment using activated carbon treatment, and (3) ozone treatment with activated carbon for their efficacy in removing 17beta-estradiol (E2) present in an aqueous solution. Both ozone and activated carbon treatments for 20 min were effective in removing E2 (initial concentration, 100 mg/L). However, both treatments have been used for two processes, and the disposal time with these treatments is more than that of another treatment. In this study, ozone treatment with activated carbon was investigated with regard to the percentage of E2 removal, pH, and chemical oxygen demand (COD). The physical and chemical characteristics of the activated carbon surface were modified due to the ozone treatment: the surface was oxidized by ozone. The surface of activated carbon exhibited polarity groups and became porous after ozone treatment. The amount of E2 adsorbed onto the ozone-treated activated carbon surface was similar to that adsorbed onto the untreated activated carbon surface. The percentage of E2 removal by ozone treatment with activated carbon was greater than that by ozone treatment alone. Moreover, the rate of E2 removal by ozone treatment with activated carbon was higher than that by ozone or activated carbon treatments alone. Ozone with activated carbon treatment may be used for the removal of E2. However, this ozone treatment for the degradation of E2 may have a greater COD than that in the case of activated carbon treatment alone.
  • Kawasaki, N.; Takashima, T.; Sagawa, K.; Yamada, H.; Shindo, K.; Kakehi, K.
    Yakugaku Zasshi PHARMACEUTICAL SOC JAPAN 129 (8) 965 - 74 0031-6903 2009 [Refereed]
     
    In April 2008, a system of special health checks and health guidance was initiated with the aim of identifying people with metabolic syndrome (visceral fat syndrome) and pre-metabolic syndrome. In this study, we investigated the relationship between health check results and abdominal circumference in 632 university faculty members. The standard value for abdominal circumference in women (> or =90) is set higher than that for men (> or =85). When this standard value is used, only 7.4% of women may be able to receive special health guidance. In the future, a follow-up survey of female subjects focusing on the difference in the standard value and an evaluation of its relationship with lifestyle-related diseases will probably be necessary. In the present study, significant positive correlations were seen between abdominal circumference and GPT and gamma-GTP, which are related to hepatic function, and between abdominal circumference and uric acid levels in males. These results indicate the possibility that abdominal circumference is related to alcohol intake. In addition, white blood cell count, red blood cell count, hemoglobin level, and hematocrit level were significantly higher in subjects with large abdominal circumference, and there were differences in hematopoietic function. There have been virtually no studies on the relationship between visceral fat and hepatic and hematopoietic functions, and a follow-up study of the present subjects in the future may shed new light on risk factors for various diseases with abdominal circumference as an indicator.
  • Kawasaki, N.; Ogata, F.; Tominaga, H.; Yamaguchi, I.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 58 (10) 529 - 35 1345-8957 2009 [Refereed]
     
    Bone char (BC) was prepared by carbonizing four types of animal biomass, and the adsorption of fluoride ions and elution of phosphate ions were investigated. It was found that the BC yield decreased as carbonization temperature increased, and that carbonization temperature had no significant effect on surface pH, base or acid consumptions. Fluoride ion adsorption was increased in BC produced at a low carbonization temperature. The adsorption mechanism of fluoride ion on BCs might be monolayer adsorption. BC can potentially be used to remove fluoride ions in drinking water. However, it was found that phosphate ions from BC are eluted due to adsorption of fluoride ions, and that ingestion of large amounts of phosphate ions inhibits reabsorption of calcium in the human body. Thus there is a need to study the elution behavior of phosphate ions. The adsorption mechanisms of fluoride ions onto BC would be a physical adsorption onto BC and phosphate ion in BC is exchanged to fluoride ion.
  • OGATA Fumihiko; KAWASAKI Naohito; YAMAGUCHI Isao; TOMINAGA Hisato
    Hyomen Kagaku The Surface Science Society of Japan 30 (12) 680 - 687 0388-5321 2009 
    Waste fibers are produced by textile industry and colored wastewater is released, the people hope to development the useful reused methods of it. And the release of colored wastewater induced aesthetically unpleasant, produced the carcinogen from chlorination. In this study, we produced the carbonaceous materials produced from waste fibers, developed the amount adsorbed and the adsorption rate of dyes. As a results, the specific surface area of waste fibers is increasing with increasing the carbonized temperatures. Amount adsorbed of each dyes onto carbonaceous materials produced from waste fibers at 1000oC is highest. In waste fibers, amount adsorbed of each dyes onto 2 h heating-2 h maintaining carbonaceous materials produced from waste fibers is increasing colored wool < untreated wool < colored wool-polyester < polyester, it showed the waste fiber from polyester is more suitable for adsorption than that of wool. Carbonaceous materials produced from waste fibers at 1000oC could treat to adsorbed the Methylene blue and Orange II in 20 min from the adsorption beginning. The carbonaceous materials produced from waste fiber would be utilized for adsorbates to remove dyes.
  • OGATA Fumihiko; KABAYAMA Mineaki; WADA Keiko; KUNOU Makoto; KAKEHI Kazuaki; KAWASAKI Naohito
    SEIKATSU EISEI (Journal of Urban Living and Health Association) Osaka Urban Living and Health Association 53 (4) 261 - 265 0582-4176 2009 
    In this study, we evaluated the adsorption of phosphate in environmental water by granular GB with binder (G-GB) at the Biyo center of the Lake Biwa-Yodo River Water Quality Preservation Organization. We measured phosphate, temperature, river temperature, humidity, pH, suspended solids (SS), turbidity, chemical oxygen demand (COD), F, Br, B, Al, Mn, Fe, Zn, Ba, Ni, Pb, Cr, As, Mo, Ag, Sn, Sb, Bi and U at the Biyo center. The measurements were performed from September 2007 to December 2008. G-GB did not show ability to adsorb phosphate or COD. The maximum detected concentrations of F, Br, B, Al, Mn, Fe, Zn, Ba, Ni and Pb were 300, 200, 150, 4.5, 250, 150, 30, 80, 30 and 10μg/L, respectively. In particular, B and Mn showed greater removal by G-GB than the other elements. The percentages of B and Mn removed by adsorption onto G-GB were 34 and 72%, respectively. We thus created a new granular adsorbent with ability to adsorb B and Mn and demonstrated its suitability for use in environmental water.
  • Burapadaja, S.; Kawasaki, N.; Charumanee, S.; Kittipongpatana, O.; Ogata, F.
    Journal of Public Health 17 (4) 251 - 256 0943-1853 2009 
    Background: Despite the fact that the market availability of medicines has been recognized as one of the most important components in the health-care system, its association with other factors is still in doubt. Objective: This study aimed at determining the factors associated with the number of trade names and products of systemic anti-infective medicines available for the market in Thailand. Methods: A cross-sectional study on the data from the Thai National List of Essential Medicines (Thai EML) 2008 and Thailand Index of Medical Specialties 2008 was undertaken. Results: Results showed a total of 702 trade names and 1,262 products from 137 generic drugs. Half of the products belonged to the classes of beta-lactam antibacterials (39%) and quinolone antibacterials (11.3%). The significant factors found were dosage forms of medicines, manufacturer types and category. The generic drugs that were prepared in more than one dosage form, produced by local manufacturers and categorized as essential medicines (EMs) would have a greater number of trade names and products than those done in one dosage form by foreign manufacturers and as non-EMs. Conclusion: There are at least three factors associated with the number of trade names and products of systemic anti-infective medicines, which include dosage forms of medicines, manufacturer types and EM category. These factors have involved the technical issue, private sector and Thai EML. One suggestion from this finding is to use the Thai EML as a means to control the market availability of systemic anti-infective products in the country. © 2009 Springer-Verlag.
  • 酵素処理植物バイオマスによるカドミウムおよび銅の吸着能
    緒方 文彦; 川﨑 直人; 佐伯 美由紀; 掛樋 一晃; 棚田 成紀
    用水と排水 50 (5) 405 - 411 2008/10
  • Kawasaki, N.; Ogata, F.; Yamaguchi, I.; Fujii, A.
    Journal of Oleo Science JAPAN OIL CHEMISTS SOC 57 (7) 391 - 6 1345-8957 2008 [Refereed]
     
    To prevent formation of trihalomethanes (THMs) in drinking water, removing precursors of trihalomethanes (PTHMs) in water resources for tap water is essential. We compared the following three treatments for removal of PTHMs: activated carbon (AC), ozone (OZ) and ozone-activated carbon combination (OZAC). Orange II (OR, an acidic dye), methylene blue (MB, a basic dye) and humic acid (HA) were used as PTHMs. HA exists abundantly as PTHM in nature. Results demonstrated that PTHMs could be decomposed or removed by either AC or OZ treatment. Efficiency of removal of HA by the three treatment methods was lower than that for removal of OR and MB, as the molecules of HA were larger than those of OR and MB. Decreases of total organic carbon values were achieved by treatment of MB with OZ or HA with AC. As for advanced water treatment, a two-step sequential process of OZ-AC treatments is currently used. However, the present results demonstrated that highly efficient removal of PTHMs could be accomplished by the addition of AC during OZ treatment.
  • Relationship between strength and life style on pharmaceutical university students in Japan and Thailand
    川﨑 直人; 種根井 重晴; 緒方 文彦; 棚田 成紀; Burapadaja S. Loetkham C; 青地克頼
    Jpn. B. Health Fit. Nutr. 13 (1) 44 - 51 2008/01
  • Kawasaki, N.; Ogata, F.; Takahashi, K.; Kabayama, M.; Kakehi, K.; Tanada, S.
    Journal of Health Science 54 (3) 324 - 329 1344-9702 2008 
    This study investigated the adsorption capacity and adsorption mechanism of phosphate by calcined aluminum oxide (GB) at temperatures of 200 to 1150°C. The results showed that GB and GB calcined at a temperature of 200°C exhibited almost no adsorption capacity, and GB calcined at temperatures of 300 or 400°C exhibited the highest adsorption capacity. After that, adsorption capacity tended to decrease with increasing calcination temperature. The specific surface area and the concentration of surface hydroxyl groups exhibited the highest values in GB calcined at temperatures of 300 and 400°C. From the above facts, it is conjectured that the specific surface area and concentration of surface hydroxyl groups contribute to the adsorption of phosphate in calcined GB. The results of X-ray diffraction showed that the structure of GB changed drastically at temperatures of 200 to 300°C and 900 to 1000°C. Also, it was evident that phosphate was adsorbed selectively even in complex solution systems containing chloride, nitrate, sulfate, hydrogen carbonate and phosphate ions, and that calcined GB is suitable for adsorption of phosphate. For the adsorption of phosphate, it was found that the optimum pH is around 4. When calcined GB is suspended in purified water, it is thought that hydroxyl groups form through dissociative adsorption with water molecules, and that these hydroxyl groups conduct ion exchange with phosphate.
  • 1/fゆらぎの強い長期の聴覚刺激による心理・生理的変化に関する基礎的研究
    伊藤輝子; 川﨑 直人; 北小路 学; 中村 武夫; 棚田 成紀; 松本和興; 畑; 青地克頼; 今木雅英
    日本健康体力栄養学会誌 13 (1) 1 - 9 2008/01
  • KAWASAKI NAOHITO; TANEI SHIGEHARU; BURAPADAJA SIRIPORN; LOETKHAM CHAOWALIT; OGATA FUMIHIKO; TANADA SEIKI
    日本生理人類学会誌 12 66 - 67 1342-3215 2007/06
  • タイ・チェンマイ市における中学生の食習慣と運動習慣に関する調査
    多根井 重晴; 川﨑 直人; 緒方 文彦; 棚田 成紀; Burapadaja S; Loetkham C; 青地克頼
    日本健康体力栄養学会誌 12 (1) 1 - 7 2007/02
  • 1/fゆらぎの強い急性の聴覚刺激による心理・生理的変化に関する基礎的研究
    松本和興; 川﨑 直人; 棚田 成紀; 伊藤輝子; 青地克頼; 今木雅英
    日本健康体力栄養学会誌 12 (2) 10 - 16 2007/02
  • Burapadaja, S.; Kawasaki, N.; Kittipongpatana, O.; Ogata, F.
    Yakugaku Zasshi The Pharmaceutical Society of Japan 127 (3) 515 - 26 0031-6903 2007 
    There are evidences describing that the prices of prescription medicines can affect users, suppliers, and, in particular, payers in the health care system. Despite the significant effects of prices, the information regarding their characteristics is scarce. The objective of this study was to examine the prices and price variations of prescription medicines in an actual setting. A cross-sectional study on the prices of prescription medicines listed in a hospital formulary was undertaken. The medicines (n=1531) listed in the formulary were recorded according to the category of the medicine (essential or non-essential medicines), manufacturer types (local or foreign), dosage forms, therapeutic classifications (classes), and prices per unit in Baht. This study used coefficients of relative variations (CRVs) to determine the extent of price variations. Results revealed that the mean prices of non-essential and foreign medicines were significantly greater than those of its counterparts by 1.7 and 21.2 times, respectively. On an average, the classes with the highest prices were blood-related, antineoplastic, and endocrinological agents, while those with the lowest prices were the psychotherapeutic, CNS, and cardiovascular agents. The majority of the medicines (37%) were in the price range of >10-100 Baht. The price variations of different classes of medicines varied from about 100% to 600%. The mean price and CRV levels (low and high) formed four groups of medicines with different risks of high prices and variations to payers. In conclusion, the prices are associated with the category and manufacturer type. The prices and their variations could be used to distinguish the classes of medicines that possess different risks of high prices and variations to payers. Identifying the classes with high prices and high variations, high prices and low variations, and low prices and high variations is necessary for careful intervention to reduce the effect of prices and their variations on payers.
  • 日本およびタイの大学生における食習慣，運動習慣に関する調査
    佐藤紀代美; 川﨑 直人; 緒方 文彦; 中村 武夫; 棚田 成紀; Loetkham C; 青地克頼
    日本健康体力栄養学会誌 12 (1) 13 - 19 2007/01
  • Relationship between states of physical or mental and sleeping habits among university students in Thailand and Japan
    多根井 重晴; 川﨑 直人; 緒方 文彦; 棚田 成紀; Burapadaja S; Loetkham C
    Jpn. B. Haelth Fit. Nutr. 12 (1) 20 - 27 2007/01
  • Burapadaja, S.; Kawasaki, N.; Charumanee, S.; Ogata, F.
    Health Policy ELSEVIER IRELAND LTD 84 (1) 67 - 74 0168-8510 2007 [Refereed]
     
    National List of Essential Medicines (NLEM) is an important policy on drugs, which also covers the drug availability. However, the link between the list and the availability of medicine products for the market is not clear. The objectives of this study were to examine the effects of essential medicines (EM) on the patterns and values of cardiovascular products available for the market in Thailand. Issues investigated were proportions of products, expansions of generic names, involvement of producers and relation between the numbers of EM generic names and production values of products. Data sources were NLEM, Thailand Index of Medical Specialities and drug statistics by Food and Drug Administration (FDA). Results revealed the availability of 623 products from 127 generic names. On average, EM products showed significantly greater proportions and EM generic names demonstrated larger expansions than non-EM. Domestic producers contributed to List A products by a significantly higher percentage than foreign, but only foreign producers introduced List D products. There was a positive and significant relation between the numbers of EM generic names and the production values of products. In conclusion, it was clear that EM had effects on the patterns and the values of cardiovascular products available for the market. Subsequent prices and expenditure due to the patterns and values of product availability could be low or high. These findings could be advantageous in using essential medicines as a means to avoid the negative consequences by addressing the significance of its kinds and numbers when selecting it in the list.
  • Survey on meal habit, hours of sleep and exercise habit of university students in Japan and Thailand
    佐藤紀代美; 川﨑 直人; 中村 武夫; 棚田 成紀; 松本和興; Leotkham C. Burapadeja S
    Jpn. B. Health Fit. Nutr. 11 15 - 22 2006/11
  • Naohito Kawasaki; Shigeharu Tanei; Fumihiko Ogata; Siriporn Burapadaja; Chaowalit Loetkham; Takeo Nakamura; Seiki Tanada
    Journal of physiological anthropology 25 (6) 377 - 82 1880-6791 2006/11 
    The number of cellular phone subscribers is increasing every year and there have been reports of health disorders related to the high-frequency radio waves. This paper considers the dependence of Thai university and high school students on cellular phones. A survey form (cellular phone dependence questionnaire: CPDQ) was distributed to 181 female and 177 male Thai university students and to 240 female and 140 male Thai high school students. The surveys were collected, Cronbach alpha coefficient was calculated, and a factor analysis was performed using the principal factor method and varimax rotation. The total scores were 16.54 to 20.04 and the Cronbach's alpha coefficients were 0.808 to 0.930. According to a factor analysis of 20 scored items, 4 factors were extracted for both male and female high school students, and the cumulative correlation coefficients of the male and female groups were 64.85% and 62.70%, respectively. Five factors were extracted for male university students and 6 factors were extracted for female university students, and the cumulative correlation coefficients were 58.08% and 57.91%, respectively. The W value results of the Shapiro-Wilk W-test for male university students, female university students, male high school students and female high school students were 0.969, 0.984, 0.964, and 0.913 respectively, thus verifying the normality of the score distributions. The total scores for the Thai university students were higher than the scores for the Thai high school students. The factor analysis of female high school students confirmed a large difference compared to male university students, male high school students, and Japanese female university students. (The Japanese students were surveyed in an earlier study by Toda et al.). Also, the CPDQ total score was high, which indicated a strong tendency toward dependence.
  • Survey on body stature and body habitus among university students in Japan and Thailand
    佐藤紀代美; 川﨑 直人; 中村 武夫; 棚田 成紀; 松本和興; Leotkham C. Burapadeja S
    Jpn. B. Health Fit. Nutr. 11 3 - 14 2006/11
  • 青年期の安静時エネルギー消費量と身体組成、血行動態、身体活動量、体力の関連性について
    青地克頼; 川﨑 直人; 中村 武夫; 北小路 学; 棚田 成紀; 大内志織; 松本和興; 関澤; 今木雅英; 田村隆教
    日本健康体力栄養学会誌 11 (1) 26 - 31 2006/08 
    青年期の安静時エネルギー消費量が、身体組成、血行動態、身体活動量および体力とそれぞれ有意に関連のあることが判明した。
  • Ogata, F.; Kawasaki, N.; Nakamura, T.; Tanada, S.
    Journal of Colloid and Interface Science ACADEMIC PRESS INC ELSEVIER SCIENCE 300 (1) 88 - 93 0021-9797 2006 [Refereed]
     
    Aluminum oxyhydroxide (boehmite, BE) shows adsorption ability of arsenious ion. In this study, we calcined BE in the temperature range 200-1150 degrees C, and examined the amount of arsenious ion adsorbed and adsorption mechanism. As a result, the adsorption amount of arsenious ion by BE calcined at 400 degrees C showed the highest value as compared with those by BE calcined at other temperatures. On the other hand, the amounts of arsenious ion adsorbed onto BE showed lower values at 200, 600, and >1000 degrees C than that by BE before calcination. The amount of surface hydroxyl group of calcined BE showed the highest value at the calcination temperature of 400 degrees C. As a result of X-ray analysis, BE showed boehmite structure at less than the calcination temperature of 300 degrees C, while BE was converted to the transitional state of aluminum oxide at more than 400 degrees C. From the result of the amount of arsenious ion adsorbed and FT-IR, it turned out that calcined BE dissociated water molecule when suspended in the water, hydroxyl group was generated on the surface, and the amount of arsenious ion adsorbed was increased because of the ion exchange of these hydroxyl groups with arsenious ions. It was clarified that an adsorbent with high adsorption ability of arsenious ion was obtained by calcination of BE.
  • Kawasaki, N.; Tanei, S.; Ogata, F.; Burapadaja, S.; Loetkham, C.; Nakamura, T.; Tanada, S.
    Journal of Physiological Anthropology Japan Society of Physiological Anthropology 25 (6) 377 - 382 1880-6791 2006 
    The number of cellular phone subscribers is increasing every year and there have been reports of health disorders related to the high-frequency radio waves. This paper considers the dependence of Thai university and high school students on cellular phones. A survey form (cellular phone dependence questionnaire: CPDQ) was distributed to 181 female and 177 male Thai university students and to 240 female and 140 male Thai high school students. The surveys were collected, Cronbach α coefficient was calculated, and a factor analysis was performed using the principal factor method and varimax rotation. The total scores were 16.54 to 20.04 and the Cronbach's α coefficients were 0.808 to 0.930. According to a factor analysis of 20 scored items, 4 factors were extracted for both male and female high school students, and the cumulative correlation coefficients of the male and female groups were 64.85% and 62.70%, respectively. Five factors were extracted for male university students and 6 factors were extracted for female university students, and the cumulative correlation coefficients were 58.08% and 57.91%, respectively. The W value results of the Shapiro–Wilk W-test for male university students, female university students, male high school students and female high school students were 0.969, 0.984, 0.964, and 0.913 respectively, thus verifying the normality of the score distributions.
    The total scores for the Thai university students were higher than the scores for the Thai high school students. The factor analysis of female high school students confirmed a large difference compared to male university students, male high school students, and Japanese female university students. (The Japanese students were surveyed in an earlier study by Toda et al.). Also, the CPDQ total score was high, which indicated a strong tendency toward dependence.
  • 川﨑 直人; 文榮 龍馬; 緒方 文彦; 中村 武夫; 多根井 重晴; 棚田 成紀
    J. Water Environ. Technol. 4 (1) 73 - 82 2006/01
  • Ogata, F.; Kawasaki, N.; Kabayama, M.; Nakamura, T.; Tanada, S.
    e-Journal of Surface Science and Nanotechnology 4 267 - 269 1348-0391 2006 
    Gibbsite, which is aluminum oxide, was calcined in the temperature range from 200 to 1150°C, and the relation between the calcination temperature and various properties of gibbsite has been examined. It is speculated based on the results of TG-DTA experiment that the structure of gibbsite changed greatly at a calcination temperature of 282.7° C. Specific surface area of gibbsite kept on increasing as the calcination temperature is elevated up to 400° C, where it reached a maximum value. In the range where the calcination temperature is higher than 400° C, specific surface area, decreased as the temperature was elevated further. In addition, it became evident from the results of XRD measurement that in the calcination temperature range lower than 200° C, the crystal kept gibbsite structure, but it changed to the structure of aluminum oxide of transition type above 300° C. and that it changed further to the structure of stable aluminum oxide when the calcination temperature was elevated over 1000°C. From these results, it is verified that by making use of the fact that the structure of gibbsite changes greatly in the calcination temperature range from 300 to 400° C, a novel adsorbent having boehmite structure can be produced. © 2006 The Surface Science Society of Japan.
  • Bun-Ei, R.; Kawasaki, N.; Ogata, F.; Nakamura, T.; Aochi, K.; Tanada, S.
    Journal of Oleo Science 55 (8) 423 - 427 1347-3352 2006 
    Vegetable biomass available in all regions of the world was focused on for the purposes of effectively utilizing food wastes, attempting to reduce the emission of carbon dioxide, and developing simple water treatment techniques in developing country. In this study, the adsorption characteristics of heavy metal ions onto vegetable biomass as bean curd lees (BC), corn cobs (CO), and wheat bran (WB) were investigated. In single solution system, larger amounts of iron ion were adsorbed onto BC than onto CO and WB. Iron and lead ions were also found to compete in adsorption to BC in binary solution system. Furthermore, the amounts of the heavy metal ions adsorbed depended on the protein content of the vegetable biomass. However, because the vegetable biomass is rich in nutrients, they are likely to render drinking water treated with them liable to putrefaction. Although viable bacterial counts increased in water with the vegetable biomasses added, the water is considered suitable for drinking for 48 h or less after the treatment. © 2006, Japan Oil Chemists' Society. All rights reserved.
  • Bun-Ei, R.; Kawasaki, N.; Nakamura, T.; Ogata, F.; Tanada, S.
    Journal of Oleo Science 55 (1) 23 - 29 1347-3352 2006 
    In order to promote the shift to zero emissions of organic wastes, it is necessary to create carbon cycling processes. On the other hand, one of the distinguishing features of the Japanese climate is its high humidity, and an adsorbent which is high ability of moisture control are needed to prevent putrefaction of wood and keep indoor spaces at a comfortable humidity. This research focused on producing a carbonaceous material produced from bean curd lees, which is a form of food waste, and studied the relationship between the surface polarity or specific surface area of carbonaceous material, and the ability of moisture control. The specific surface area of the carbonaceous material was measured, and the highest value was exhibited in carbonaceous material produced at a temperature of 1173K. From this result, it appears that a microstructure develops as the carbonization temperature increases, but when the carbonization temperature is increased further, the specific surface area decreases due to merging of pores. Also, the ability of moisture control of charcoal is 22, and the ability of moisture control of the carbonaceous material produced from bean curd lees is a maximum of 198. This suggests that the material can be used in applications as a moisture control material. This work clarified that the ability of moisture control of the carbonaceous material increases to the degree that there are fewer phenolic hydroxyl groups and carboxyl groups in the carbonaceous material surface. © 2006, Japan Oil Chemists' Society. All rights reserved.
  • Kawasaki, N.; Kinoshita, H.; Oue, T.; Nakamura, T.; Tanada, S.
    Journal of Oleo Science 55 (1) 31 - 35 1347-3352 2006 
    Coffee grounds are a vegetable biomass that can be efficiently burned. The carbon dioxide generated by burning coffee grounds is affecting global warming. On the other hand, ammonia generated in the places such as toilets or farms produces a bad smell. In the present study, we have analyzed the possibility of ammonia elimination using the carbonaceous materials produced from coffee grounds. Carbonaceous materials were prepared by the microwave treatment of coffee grounds. We observed that the saturated amounts of ammonia adsorbed by some of the carbonaceous materials produced from coffee grounds were greater than that adsorbed by activated carbon. In contrast, the activated carbon adsorption rate for ammonia was higher than those of the carbonaceous materials. Therefore, carbonaceous materials produced from coffee grounds could be utilized for the removal of ammonia in the gaseous phase. © 2006, Japan Oil Chemists' Society. All rights reserved.
  • Paraquat and diquat removal by chitosan derivatives
    棚田 成紀; 中村 武夫; 川﨑 直人
    Bull. Pharm. Res. Technol. Inst. 13 35 - 41 2005/03
  • 川崎 直人; 中村 武夫; 棚田 成紀
    化学工学会 研究発表講演要旨集 公益社団法人 化学工学会 2005 797 - 797 2005
  • T Tokimoto; N Kawasaki; T Nakamura; J Akutagawa; S Tanada
    JOURNAL OF COLLOID AND INTERFACE SCIENCE ACADEMIC PRESS INC ELSEVIER SCIENCE 281 (1) 56 - 61 0021-9797 2005/01 
    In an attempt to reuse food waste for useful purposes, we investigated the possibility of using coffee grounds to remove lead ions from drinking water. We studied the lead ion adsorption characteristics of coffee beans and grounds by measuring their fat and protein content, adsorption isotherms for lead ions, and adsorption rates for lead ions. The number of lead ions adsorbed by coffee grounds did not depend on the kind of coffee beans or the temperature at which adsorption tests were performed. The rate of lead ion adsorption by coffee grounds was directly proportional to the amount of coffee grounds added to the solution. When coffee grounds were degreased or boiled, the number of lead ions decreased. When proteins contained in coffee grounds were denatured, the lead ion adsorption was considerably reduced. The lead ion adsorption capacity of coffee grounds decreased with increased concentration of perchloric acid used for treating them and disappeared with 10% perchloric acid. The experiments demonstrated that proteins contained in coffee beans depend upon the adsorption of lead ion. The present study gave an affirmative answer to the possibility Of using, coffee grounds, an abundant food waste, for removing lead ions from drinking water. (C) 2004 Elsevier Inc. All rights reserved.
  • Kabayama, M.; Kawasaki, N.; Nakamura, T.; Tanada, S.
    e-Journal of Surface Science and Nanotechnology 3 63 - 69 1348-0391 2005 
    Boehmite (aluminum oxyhydroxide, BE) selectively adsorbs phosphate ion. Recently, we studied the recovery efficiency of phosphate ion and the adsorption/desorption mechanism by calcining the BE surface in the temperature range of 200-1150°C. As a result, the amount of phosphate ion adsorbed/desorbed by BE at a calcining temperature of 400-700°C exhibited a higher value than the BE at other calcining temperatures, and the recovery efficiency of the phosphate ion was 90% or higher. On the other hand, the amount of phosphate ion adsorbed/desorbed onto BE at a calcining temperature of 1100°C or higher exhibited a lower value than the BE before calcining. Based on the phosphate ion adsorption/desorption behavior results, and the XRD and FT-IR results, it was determined that when the calcined BE is suspended in water, water molecules are dissociated, producing hydroxyl groups on the surface, and these hydroxyl groups exchange ions with the phosphate ion, thus the amount of phosphate adsorbed ion reaches a maximum. The phosphate ion adsorbed by BE was adsorbed by a sodium hydroxide solution, just like the BE before calcination. It became evident that by calcining BE, it is possible to obtain an adsorbent with a high phosphate ion recovery efficiency. © 2005 The Surface Science Society of Japan.
  • Naohito Kawasaki; Hideo Kinoshita; Takashi Oue; Takeo Nakamura; Seiki Tanada
    Journal of colloid and interface science ACADEMIC PRESS INC ELSEVIER SCIENCE 275 (1) 40 - 3 0021-9797 2004/07 [Refereed]
     
    The adsorption behavior of benzene, toluene, o-xylene, m-xylene, and p-xylene onto activated carbon was investigated using the flow method. The removal efficiency of aromatic hydrocarbons in the gaseous phase was estimated based on the adsorption kinetic constants and the saturated amount of aromatic hydrocarbons adsorbed on the activated carbon. The saturated amount of benzene and toluene adsorbed was greater than that of xylene adsorbed because the molecular sizes of benzene and toluene are smaller than that of xylene. The adsorption kinetic constant increased in the order of xylene, toluene, and benzene. Those of the three xylene isomers were similar. These results indicated that the adsorption rate of benzene by the activated carbon was the fastest and the kinetic constant depended upon the different between the boiling point and the melting point and the molecular size of the aromatic hydrocarbons.
  • Kawasaki, N.; Kinoshita, H.; Oue, T.; Nakamura, T.; Tanada, S.
    Journal of Colloid and Interface Science ACADEMIC PRESS INC ELSEVIER SCIENCE 275 (1) 40 - 43 0021-9797 2004 
    The adsorption behavior of benzene, toluene, o-xylene, m-xylene, and p-xylene onto activated carbon was investigated using the flow method. The removal efficiency of aromatic hydrocarbons in the gaseous phase was estimated based on the adsorption kinetic constants and the saturated amount of aromatic hydrocarbons adsorbed on the activated carbon. The saturated amount of benzene and toluene adsorbed was greater than that of xylene adsorbed because the molecular sizes of benzene and toluene are smaller than that of xylene. The adsorption kinetic constant increased in the order of xylene, toluene, and benzene. Those of the three xylene isomers were similar. These results indicated that the adsorption rate of benzene by the activated carbon was the fastest and the kinetic constant depended upon the different between the boiling point and the melting point and the molecular size of the aromatic hydrocarbons. (C) 2004 Elsevier Inc. All rights reserved.
  • Takeo Nakamura; Mizuho Hirata; Naohito Kawasaki; Seiki Tanada; Takamichi Tamura; Yutaka Nakahori
    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering MARCEL DEKKER INC 38 (3) 555 - 62 1093-4529 2003/03 [Refereed]
     
    The adsorption ability of charcoal from extracted residue of coffee beans for indigo carmine removal was investigated by the batch method. Differences in the removal ratio and removal rate of indigo carmine could be explained by differences in the properties of charcoal. In the relationship between the amount of indigo carmine adsorbed and the square root of elapsed time, a good linearity was recognized. Since the relationship between the amount of indigo carmine adsorbed and square root of elapsed time showed a good linearity, the intraparticle diffusion of indigo carmine onto pores of adsorbents was identified as the rate-limiting step in the adsorption process.
  • Tanada Seiki; Nakamura Takeo; Kawasaki Naohito
    Bulletin of Pharmaceutical Research and Technology Institute Kinki University 12 (12) 91 - 98 0919-7567 2003 
    医薬品の誤飲・誤用による急性中毒の初期処置において、第一選択経口吸着剤とされている活性炭の評価に関し、テオフィリンの吸着特性に対する粒子サイズの影響について検討し、粒子サイズが小さいものほど有効であることを明らかにした。
  • Takeo Nakamura; Yoshihito Oida; Kazuoki Matsumoto; Naohito Kawasaki; Seiki Tanada
    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering MARCEL DEKKER INC 37 (5) 905 - 12 1093-4529 2002 [Refereed]
     
    The effective use of activated carbon as oral adsorbent in the primary treatment of acute acetaminophen poisoning was studied. The adsorption characteristics of acetaminophen onto activated carbons in presence of sorbitol were investigated in vitro. Both the equilibrium amount adsorbed and the removal rate of acetaminophen onto activated carbon were decreased with the increase of sorbitol concentration in solutions. The sorbitol concentration independency of the inhibition to the acetaminophen adsorption was recognized. It was concluded that the addition of sorbitol to the suspension of activated carbon inhibited the acetaminophen adsorption by activated carbon.
  • Nakanishi, A.; Tamai, M.; Kawasaki, N.; Nakamura, T.; Araki, M.; Tanada, S.
    Journal of Colloid and Interface Science ACADEMIC PRESS INC ELSEVIER SCIENCE 255 (1) 59 - 63 0021-9797 2002 [Refereed]
     
    The recycling of organic wastes has become very important and the development of technology for recycling organic wastes needs to sustain industrial development. In this study, techniques for producing carbonaceous materials from organic wastes are described and water adsorption is characterized. The organic wastes used are coffee grounds and oolong tea leaves carbonized at 673 to 1073 K. The iodine adsorption capacity of the carbonaceous materials increased with increased carbonization temperature. The amount of water adsorbed onto the carbonization materials produced from oolong tea leaves at 873 K for 2 h was the highest. The Freundlich constant 1/n and the differential heat of adsorption of the carbonaceous materials produced from oolong tea leaves were greater than that of the carbonaceous materials produced from coffee grounds. The ability to humidity control can be estimated by the difference between the amount of water adsorbed relative pressure 0.90 and that at relative pressure 0.55. The ability to humidity control was the greatest for the carbonaceous materials produced from the oolong tea leaves at 873 K for 2 h and did not depend upon the adsorption temperature. These results indicated that the carbonaceous materials produced from oolong tea leaves at 873 K for 2 h could have more humidity control.
  • Nakamura, T.; Yoshimura, K.; Kogirima, M.; Kawasaki, N.; Tanada, S.
    Toxicological and Environmental Chemistry 81 (3-4) 147 - 152 0277-2248 2001 [Refereed]
     
    Adsorption characteristics of acetaminophen onto activated carbon of varying particle sizes was investigated for emerging treatment of acute poisoning in vitro. No difference in the equilibrium amount of acetaminophen adsorbed among activated carbon of varying particle size was observed. This result could be explained by the properties of activated carbon. The smaller the particle size of activated carbon, the faster the acetaminophen was removed. It was assumed that the increase of contact surface area (external surface area) due to smaller particle size accelerated the adsorption of acetaminophen onto activated carbon.
  • K BOKI; N KAWASAKI
    FOOD HYDROCOLLOIDS PLENUM PRESS DIV PLENUM PUBLISHING CORP 379 - 382 1993 [Refereed]

Books etc

Conference Activities & Talks

  • 琵琶湖における造粒ベーマイトを用いたリン酸吸着能  [Not invited]
    緒方 文彦; 冨永壽人; 藪谷仁志; 川﨑 直人; 樺山峰明; 和田桂子
    2011/03
  • 大学生の肥満と朝食欠食およびやせ志向との関連性に関する研究  [Not invited]
    川﨑 直人; 緒方 文彦; 冨永壽人; 木下 充弘; 掛樋 一晃; 佐川和則
    2011/03
  • 大学生の朝食欠食と体格誤認に関する実態調査  [Not invited]
    冨永壽人; 緒方 文彦; 掛樋 一晃; 木下 充弘; 川﨑 直人; 佐川和則
    2011/03
  • 綿由来炭素材料とオゾン併用による染色排水処理に関する基礎研究  [Not invited]
    冨永 壽人; 緒方 文彦; 藪谷 仁志; 川﨑 直人
    2010/10  第60回 日本薬学会近畿支部総会・大会（大阪）
  • 簡易懸濁法適用時におけるベシル酸アムロジピンと水道水含有金属との相互作用  [Not invited]
    緒方 文彦; 掛樋 一晃; 川﨑 直人; 林友典; 西浦早織; 松岡寛; 立花貞信
    2010/10  第60回 日本薬学会近畿支部総会・大会（大阪）
  • コーヒー豆かすによる水道水中における硝酸・亜硝酸態窒素の除去  [Not invited]
    藪谷 仁志; 緒方 文彦; 冨永 壽人; 川﨑 直人
    2010/10  第60回 日本薬学会近畿支部総会・大会（大阪）
  • Recovery of Phosphate by Dried Aluminum Hydroxide Gel  [Not invited]
    川﨑 直人; 緒方 文彦
    The 13th Asia Pacific Confederation of Chemical Engineering Congress  2010/10  台湾  The 13th Asia Pacific Confederation of Chemical Engineering Congress
  • 大学生の食習慣および体格評価の誤認に関する調査  [Not invited]
    冨永 壽人; 緒方 文彦; 佐川 和則; 木下 充弘; 掛樋 一晃; 川﨑 直人
    2010/09  フォーラム2010 衛生薬学・環境トキシコロジー（東京）
  • 大学生における睡眠習慣と身体的・精神的状態との関連性  [Not invited]
    緒方 文彦; 冨永 壽人; 佐川 和則; 木下 充弘; 掛樋 一晃; 川﨑 直人
    2010/09  フォーラム2010 衛生薬学・環境トキシコロジー（東京）
  • 吸着法による廃食用油のリサイクルに関する基礎的研究  [Not invited]
    緒方 文彦; 川﨑 直人; 青山秀幸; 幸泉智英; 谷脇孝典
    2010/09  日本油化学会第49年会（北海道）
  • コーヒー豆かす由来炭素材料による飲料水中におけるアニオンの吸着特性  [Not invited]
    藪谷 仁志; 緒方 文彦; 冨永 寿人; 川﨑 直人
    2010/09  フォーラム2010 衛生薬学・環境トキシコロジー（東京）
  • Removal of Fluoride Ion by New Carbonaceous Materials in Aqueous Phase  [Not invited]
    川﨑 直人; 緒方 文彦; 冨永 壽人; S. Burapadaja; C. Loetkham
    39th International Conference on Coordination Chemistry  2010/07  オーストラリア  39th International Conference on Coordination Chemistry
  • 繊維産業における繊維由来炭素材料による合成染料の除去  [Not invited]
    山下 雄司; 山口 勲; 緒方 文彦; 冨永 壽人; 藪谷 仁志; 川﨑 直人
    2010/03  日本薬学会 130年会（岡山）
  • 簡易懸濁法におけるベシル酸アムロジピンを主成分とする先発品および後発品の溶出量の比較検討  [Not invited]
    林友典; 緒方 文彦; 川﨑 直人; 掛樋 一晃; 西浦早織; 松岡寛; 立花貞信
    2010/03  日本薬学会 130年会（岡山）
  • 琵琶湖における水質調査および造粒GBを用いた水質浄化に関する研究  [Not invited]
    緒方 文彦; 掛樋 一晃; 川﨑 直人; 樺山峰明; 和田桂子; 熊谷
    2010/03  第44回日本水環境学会年会（福岡）
  • 塩化カルシウム処理したコーヒー豆かす由来炭素材料によるフッ素の除去  [Not invited]
    藪谷 仁志; 緒方 文彦; 冨永 壽人; 山口 勲; 川﨑 直人
    2010/03  日本薬学会 130年会（岡山）
  • 食品廃棄物の炭化による循環型社会の形成  [Not invited]
    川﨑 直人; 緒方 文彦
    2010/01  第26回エネルギーシステム・経済・環境コンファレンス（東京）
  • 学生のニーズ把握と具体的な問題解決手法の修得を目的とした学生ワークショップの試み  [Not invited]
    安原 智久; 川﨑 直人; 八木 秀樹; 川瀬 篤史; 伊藤 栄次; 大鳥 徹; 和田 哲幸; 松山 賢治; 岩城 正宏
    日本薬学会第130年会  2010  日本薬学会第130年会
  • 造粒ギブサイトによる3価ヒ素および6価クロムの吸着能  [Not invited]
    緒方 文彦; 冨永 壽人; 山口 勲; 川﨑 直人; 樺山峰明
    2009/11  フォーラム2009 衛生薬学・環境トキシコロジー（沖縄）
  • 無機態窒素除去のための塩化カルシウムによる炭素材料表面処理  [Not invited]
    藪谷 仁志; 緒方 文彦; 冨永 壽人; 山口 勲; 川﨑 直人
    2009/11  フォーラム2009 衛生薬学・環境トキシコロジー（沖縄）
  • 廃繊維由来炭素材料を用いた繊維事業所からの染料排水処理  [Not invited]
    山口 勲; 緒方 文彦; 冨永 壽人; 藪谷 仁志; 川﨑 直人
    2009/11  フォーラム2009 衛生薬学・環境トキシコロジー（沖縄）
  • 希少金属であるバナジウムおよびモリブデンの造粒GBによる回収  [Not invited]
    冨永 壽人; 緒方 文彦; 山口 勲; 藪谷 仁志; 川﨑 直人
    2009/11  フォーラム2009 衛生薬学・環境トキシコロジー（沖縄）
  • 繊維廃棄物による鉛および銅の除去能に関する研究  [Not invited]
    冨永 壽人; 緒方 文彦; 山口 勲; 藪谷 仁志; 川﨑 直人
    2009/10  第59回 日本薬学会近畿支部総会・大会（大阪）
  • 簡易懸濁法におけるアムロジピン含有錠剤の溶解能  [Not invited]
    緒方 文彦; 川﨑 直人; 掛樋 一晃; 林友典; 西浦早織; 松岡寛; 立花貞信
    2009/10  第59回 日本薬学会近畿支部総会・大会（大阪）
  • 廃繊維由来炭素材料を用いた繊維事業所からの染料排水処理  [Not invited]
    山口 勲; 緒方 文彦; 冨永 壽人; 藪谷 仁志; 川﨑 直人
    2009/10  第59回 日本薬学会近畿支部総会・大会（大阪）
  • コーヒー豆かすによる亜硝酸態窒素および硝酸態窒素の除去  [Not invited]
    藪谷 仁志; 緒方 文彦; 冨永 壽人; 山口 勲; 川﨑 直人
    2009/10  第59回 日本薬学会近畿支部総会・大会（大阪）
  • Formation of trihalomethanes from dyes by ozone treatment  [Not invited]
    川﨑 直人; 緒方 文彦
    2009/08  4th International Congress of Chemistry and Environment ICCE 2009 (Thailand)
  • 簡易懸濁法におけるベシル酸アムロジピンを主成分とする先発品および後発品と金属イオンとの相互作用  [Not invited]
    林友典; 緒方 文彦; 川﨑 直人; 掛樋 一晃; 西浦早織; 松岡寛; 立花貞信
    2009/03  日本薬学会第129年会（京都）
  • 琵琶湖におけるアルミニウム系化合物を用いたリン酸回収に関する研究  [Not invited]
    緒方 文彦; 川﨑 直人; 樺山峰明; 和田桂子
    2009/03  第43回水環境学会年会（山口）
  • 特定健診における腹囲と血液検査との関連性に関する統計解析  [Not invited]
    川﨑 直人; 村上 悦子; 山田 秀和; 掛樋 一晃; 高島規郎
    2009/03  日本薬学会第129年会（京都）
  • 火力発電所におけるフライアッシュからのレアメタルの回収  [Not invited]
    冨永 壽人; 緒方 文彦; 山口 勲; 正田 智子; 川﨑 直人
    2009/03  日本薬学会第129年会（京都）
  • 廃線維由来炭素材料による染料の除去  [Not invited]
    山口 勲; 緒方 文彦; 冨永 壽人; 川﨑 直人
    2009/03  日本薬学会第129年会（京都）
  • Ozone-Activated carbon combination treatment of precursors of trihalomethanes  [Not invited]
    川﨑 直人; 緒方 文彦
    2008/11  International Conference on Environment 2008 (Malaysia)
  • 火力発電所におけるフライアッシュからのレアメタルの溶出能  [Not invited]
    冨永 壽人; 緒方 文彦; 山口 勲; 正田 智子; 川﨑 直人
    2008/10  第58回日本薬学会近畿支部総会・大会（神戸）
  • 染色廃水処理のための廃繊維由来炭素材料による染料の吸着速度  [Not invited]
    山口 勲; 緒方 文彦; 冨永 壽人; 井上 彩; 川﨑 直人
    2008/10  第58回日本薬学会近畿支部総会・大会（神戸）
  • タイ及び日本の薬学部大学生の身体的･精神的状態に関する調査  [Not invited]
    川﨑 直人; 緒方 文彦
    2008/10  第67回日本公衆衛生学会総会（福岡）
  • 水酸化アルミニウムゲルによるリン酸イオン吸・脱着能  [Not invited]
    緒方 文彦; 川﨑 直人; 掛樋 一晃; 樺山峰明
    2008/09  化学工学会第40回秋季大会（仙台）
  • 染料の活性炭を同時併用したオゾン処理(OZAC)に関する研究  [Not invited]
    川﨑 直人; 緒方 文彦; 山口 勲; 冨永 壽人
    2008/09  化学工学会沖縄大会 （沖縄）
  • Removal of Fluoride Ion by Bone Char Produced from Animal Biomass  [Not invited]
    川﨑 直人; 緒方 文彦
    2008/08  12th APCChE Congress (China)
  • Production of Carbonaceous Materials from Waste Fibre  [Not invited]
    緒方 文彦; 川﨑 直人; 掛樋 一晃
    2008/08  12th APCChE Congress (China)
  • 染色排水処理を指向した廃繊維由来吸着剤の創製  [Not invited]
    川﨑 直人; 緒方 文彦; 山口 勲; 冨永 壽人
    2008/06  分離技術会年会2008 （東京）
  • 簡易懸濁法に使用される薬剤と水道水中の金属イオンとの相互作用  [Not invited]
    林友典; 緒方 文彦; 川﨑 直人; 掛樋 一晃; 西浦早織; 松岡
    2008/03  日本薬学会第128年会 （横浜）
  • 染料含有排水処理のための廃繊維由来炭素材料の創製  [Not invited]
    緒方 文彦; 川﨑 直人; 掛樋 一晃; 棚田 成紀
    2008/03  日本薬学会第128年会 （横浜）
  • 廃繊維の炭化による吸着剤としての再資源化技術の開発  [Not invited]
    川﨑 直人; 緒方 文彦; 棚田 成紀
    2008/01  第24回エネルギーシステム・経済・環境コンファレンス（東京）
  • Recovery of phosphate from sea water using boehmite with sulfate group  [Not invited]
    川﨑 直人; 緒方 文彦; 棚田 成紀; 樺山峰明
    2007/12  SICC-5/ APCE2007 (Singapore)
  • Adsorption Mechanism of Arsenic and Chromium onto Calcined Gibbsite  [Not invited]
    緒方 文彦; 川﨑 直人; 棚田 成紀; 樺山 峰明
    2007/12  SICC-5/ APCE2007 (Singapore)
  • 植物バイオマス小麦ふすまによる銅およびカドミウムイオンの吸着能  [Not invited]
    佐伯 美由紀; 川﨑 直人; 緒方 文彦; 高橋 幸三; 棚田 成紀
    2007/10  第57回日本薬学会近畿支部総会・大会（大阪）
  • 循環型社会を目指した造粒水酸化セリウムによるリン回収法の検討  [Not invited]
    高橋 幸三; 川﨑 直人; 緒方 文彦; 佐伯 美由紀; 棚田 成紀
    2007/10  第57回日本薬学会近畿支部総会・大会（大阪）
  • 内分泌撹乱物質ノニルフェノールの廃棄物由来炭素材料による除去  [Not invited]
    川﨑 直人; 緒方 文彦; 棚田 成紀
    2007/10  第66回日本公衆衛生学会総会 （松山）
  • シックハウス症候群防止を指向した生活環境中からのホルムアルデヒド除去  [Not invited]
    棚田 成紀; 緒方 文彦; 川﨑 直人
    2007/10  第66回日本公衆衛生学会総会 （松山）
  • ギブサイト由来新規亜ヒ酸除去剤の開発  [Not invited]
    緒方 文彦; 川﨑 直人; 高橋 幸三; 掛樋 一晃; 棚田 成紀
    2007/09  化学工学会第39回秋季大会（札幌）
  • 3種のアルミニウム系化合物による6価クロム吸着能  [Not invited]
    川﨑 直人; 緒方 文彦; 佐伯 美由紀; 棚田 成紀
    2007/09  化学工学会第39回秋季大会（札幌）
  • ギブサイトによる6価クロムイオンの吸着能  [Not invited]
    緒方 文彦; 川﨑 直人; 高橋 幸三; 佐伯 美由紀; 棚田 成紀
    2007/07  第33回日本環境学会研究発表会（東京）
  • 酵素処理植物バイオマスによるカドミウム・銅の吸着能  [Not invited]
    緒方 文彦; 川﨑 直人; 高橋 幸三; 中村 武夫; 棚田 成紀
    2007/03  第41回日本水環境学会年会（大阪）
  • 簡易懸濁法に影響を及ぼす金属カチオンおよび一般細菌数の院内水質調査  [Not invited]
    林友典; 緒方 文彦; 川﨑 直人; 棚田 成紀; 掛樋 一晃; 西浦早織; 松岡寛; 立花貞信; 久保修一
    2007/03  日本薬学会127年会（富山）
  • リン酸回収における造粒水酸化セリウムの実用性  [Not invited]
    高橋 幸三; 川﨑 直人; 緒方 文彦; 中村 武夫; 棚田 成紀
    2007/03  日本薬学会127年会（富山）
  • リン循環型社会を指向した水酸化アルミニウムゲルによる新規吸着剤の開発  [Not invited]
    高橋 幸三; 川﨑 直人; 緒方 文彦; 中村 武夫; 棚田 成紀
    2007/03  第41回日本水環境学会年会（大阪）
  • タイの主要河川（チャオプラヤ川，ピン川）における水質調査  [Not invited]
    棚田 成紀; 川﨑 直人; 緒方 文彦; 高橋 幸三; 中村 武夫; Siriporn BURAPADAJA
    2007/03  日本薬学会127年会（富山）
  • 有機性廃棄物の再資源化による炭素循環型社会の構築  [Not invited]
    川﨑 直人; 中村 武夫; 緒方 文彦; 棚田 成紀
    2007/01  第23回エネルギーシステム・経済・環境コンファレンス（東京）
  • オカラを原料とした炭素系吸着剤によるインジゴカルミン除去  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 田村 隆教
    第３３回炭素材料学会年会  2006/12  札幌  第３３回炭素材料学会年会
  • 水酸化アルミニウムゲルによる亜ヒ酸イオンの吸着能  [Not invited]
    緒方 文彦; 川﨑 直人; 中村 武夫; 棚田 成紀
    2006/11  日本化学会西日本大会 （沖縄）
  • 有機性廃棄物の種々の活性炭法による調湿剤の開発  [Not invited]
    川﨑 直人; 緒方 文彦; 中村 武夫; 棚田 成紀
    2006/11  日本化学会西日本大会 （沖縄）
  • 食品廃棄物（ユズ搾りかす）の染料除去用炭素系吸着剤としての資源化有効利用  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 田村 隆教
    第65回日本公衆衛生学会総会  2006/10  富山  第65回日本公衆衛生学会総会
  • 電磁波による健康障害防止を指向した日本・タイ学生の携帯電話使用度に関する調査研究  [Not invited]
    棚田 成紀; 川﨑 直人; 多根井 重晴; 中村 武夫
    2006/10  第65回日本公衆衛生学会総会（富山）
  • 第一次予防を指向した日本およびタイにおける中学生の健康意識調査  [Not invited]
    川﨑 直人; 多根井 重晴; 中村 武夫; 棚田 成紀
    2006/10  第65回日本公衆衛生学会総会（富山）
  • 富栄養化防止を指向した水酸化セリウムによるリン酸イオンの吸・脱着能  [Not invited]
    高橋 幸三; 川﨑 直人; 中村 武夫; 緒方 文彦; 棚田 成紀
    2006/10  第56回日本薬学会近畿支部総会・大会（京都）
  • 植物バイオマスによる飲料水中の鉄・鉛イオンの除去  [Not invited]
    緒方 文彦; 川﨑 直人; 中村 武夫; 棚田 成紀
    2006/09  農業環境工学関連７学会2006 （北海道）
  • 数種のアルミニウム系化合物による亜ヒ酸イオンの吸着能  [Not invited]
    緒方 文彦; 川﨑 直人; 中村 武夫; 棚田 成紀
    2006/09  第20回日本吸着学会研究発表会 （大阪）
  • コーヒー豆かすによるアンモニアの脱臭効果に関する基礎的研究  [Not invited]
    川﨑 直人; 緒方 文彦; 中村 武夫; 棚田 成紀
    2006/09  農業環境工学関連７学会2006 （北海道）
  • Removal of heavy metal ions by vegetable biomass  [Not invited]
    川﨑 直人; 緒方 文彦; 中村 武夫; 棚田 成紀
    2006/08  11th APCChE Congress (Malaysia)
  • Removal of arsenious ion by calcined boehmite in drinking water  [Not invited]
    緒方 文彦; 川﨑 直人; 中村 武夫; 棚田 成紀
    2006/08  11th APCChE Congress (Malaysia)
  • 酸処理植物バイオマスによるカドミウムおよび銅の除去能  [Not invited]
    緒方 文彦; 川﨑 直人; 中村 武夫; 棚田 成紀
    2006/06  第32回日本環境学会研究発表会 （島根）
  • Effective removal of diquat by activated carbon  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 田村 隆教
    The 4th International Congress of Asian Society of Toxicology  2006/06  Zhuhai, China  The 4th International Congress of Asian Society of Toxicology
  • 鉛イオン除去およびマグネシウムイオン溶出の両機能を有する高機能性吸着剤の開発  [Not invited]
    棚田 成紀; 川﨑 直人; 中村 武夫; 緒方 文彦
    2006/03  日本薬学会126年会 （仙台）
  • 焼成ベーマイトによる亜ヒ酸と六価クロムの除去  [Not invited]
    緒方 文彦; 川﨑 直人; 中村 武夫; 棚田 成紀
    2006/03  日本薬学会126年会 （仙台）
  • ベーマイトの表面水酸基とリン吸着能との関連性  [Not invited]
    川﨑 直人; 中村 武夫; 緒方 文彦; 棚田 成紀; 樺山峰明
    2006/03  日本薬学会126年会 （仙台）
  • 廃棄性バイオマスによる水環境中鉛・鉄イオンの除去  [Not invited]
    川﨑 直人; 中村 武夫; 棚田 成紀
    2006/01  第22回エネルギーシステム・経済・環境コンファレンス（東京）
  • Production of Adsorbents from Soybean Residue for Humic Acid Removal  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 田村 隆教
    Biomass-Asia Form  2006/01  Tokyo  Biomass-Asia Form
  • 黄帝内経素問（四気調神大論篇）にみる生活習慣病予防  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 寺田 博行
    日本社会薬学会年会第24年会  2005/11  東京  日本社会薬学会年会第24年会
  • ベーマイト表面の焼成によるリン酸イオンの吸・脱着特性  [Not invited]
    樺山 峰明; 棚田 成紀; 川﨑 直人; 中村 武夫
    第24回日本表面科学講演大会  2005/11  東京  第24回日本表面科学講演大会
     
    ベーマイト表面を異なる温度で焼成し、温度の違いによる結晶構造の違いを明らかにした。
  • オカラ由来炭素材料による水分吸・脱着挙動  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫; 樺山 峰明
    第24回日本表面科学講演大会  2005/11  東京  第24回日本表面科学講演大会
     
    オカラを異なる温度で炭化し、調湿性能について検討し、日本の家屋で適切な調湿剤を創製した。
  • Removal of arsenious acid by calcined boehmite in drinking water  [Not invited]
    川﨑 直人; 中村 武夫; 棚田 成紀
    2005/11  The World Conference on Physics and Sustainable Development (South Africa)
  • Adsorption behavior of phosphate aluminum compounds for preventing eutrophication  [Not invited]
    川﨑 直人; 中村 武夫; 棚田 成紀
    2005/11  The World Conference on Physics and Sustainable Development (South Africa)
  • 焼成べーマイトによる飲料水中の亜ヒ酸イオン除去に関する基礎的研究  [Not invited]
    緒方 文彦; 川﨑 直人; 中村 武夫; 中村 尚文; 棚田 成紀
    2005/10
  • 日本およびタイの大学生の体格・体型に関する調査  [Not invited]
    川﨑 直人; 中村 武夫; 棚田 成紀; 佐藤紀代美
    2005/10
  • タイにおける各種感染症の罹患者数と生活状況の指標との関連性  [Not invited]
    棚田 成紀; 川﨑 直人; 中村 武夫; 佐藤紀代美
    2005/10
  • タイ,日本両国における大学生の睡眠,食・運動習慣の実態調査  [Not invited]
    中村 尚文; 川﨑 直人; 緒方 文彦; 中村 武夫; 棚田 成紀
    2005/10
  • オカラ由来活性炭によるトリハロメタン生成前駆物質の除去  [Not invited]
    中村 武夫; 棚田 成紀; 川﨑 直人; 前田 雄大; 田村隆教
    第63回日本公衆衛生学会総会  2005/10  松江  第63回日本公衆衛生学会総会
     
    豆腐や大豆タンパク質等の大豆加工品製造において副生されるオカラより活性炭を製し、それらによるトリハロメタン前駆物質であるフミン酸の除去特性について検討し、効率よく除去できる優れた水処理剤用吸着剤となりうることを明らかにした。
  • オカラ由来吸着剤によるフェノール除去に関する基礎的研究  [Not invited]
    前田 雄大; 棚田 成紀; 中村 武夫; 川﨑 直人; 中村 尚文
    第54回日本薬学会近畿支部総会・大会  2005/10  神戸  第54回日本薬学会近畿支部総会・大会
     
    オカラを原料に炭素材料を製し、医療廃水の処理を指向し、フェノールの除去性能について明らかにした。
  • 食事環境下における長期受動的音楽聴取による気分状態の変化と食生活習慣の改善に関する実験的研究  [Not invited]
    畑 沙織; 棚田 成紀; 川﨑 直人; 中村 武夫; 松本 和興; 坂本; 真理; 関澤 文; 江原 史朗; 青地 克頼; 田村 隆教
    第52回日本食糧改善学会学術総会  2005/09  徳島  第52回日本食糧改善学会学術総会
  • 青年女子の運動歴と身体組成および体力の関連性について  [Not invited]
    青地 克頼; 棚田 成紀; 中村 武夫; 川﨑 直人; 大内 志織; 脇村; 松本 和興
    第52回日本栄養改善学会学術総会  2005/09  徳島  第52回日本栄養改善学会学術総会
  • 急性および慢性の受動的ヴァイオリン曲音楽曝露の代謝異常に及ぼす影響  [Not invited]
    松本 和興; 棚田 成紀; 川﨑 直人; 中村 武夫; 松本 真理; 江原 史朗; 青地 克頼; 田村 隆教
    第52回日本栄養改善学会学術総会  2005/09  徳島  第52回日本栄養改善学会学術総会
  • Recycle technology of coffee grounds as vegetable biomass for preventing of global warming  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫
    8th International Global Atomospheric Chemistry Conference  2005/09  Christchurch. New Zealand  8th International Global Atomospheric Chemistry Conference
     
    コーヒー豆かすを焼却処分することなく再利用した場合の二酸化炭素量の排出削減量を算出した。さたに、従来の炭化法に比べマイクロ波照射による炭化法の有効性を明らかにした。
  • Hydrogen sulfide removal by iron and zinc containing activated carbon  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 田村 隆教; 内田 治
    The 16th Rgional Conference of Clean Air and Environment in Asia Pacifc Area  2005/08  Tokyo  The 16th Rgional Conference of Clean Air and Environment in Asia Pacifc Area
  • 薬用炭によるジクワット除去における共存物質の吸着促進・妨害効果  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀
    第27回日本中毒学会総会・学術集会  2005/07  川崎  第27回日本中毒学会総会・学術集会
  • 腸管洗浄液中における活性炭へのアセトアミノフェンの吸着特性  [Not invited]
    中村 武夫; 棚田 成紀; 川﨑 直人
    第26回日本中毒学会総会  2005/07  広島  第26回日本中毒学会総会
     
    消化管に残存する薬物の効果的な対外への排出に関し、第一選択吸着剤である活性炭に対するアセトアミノフェンの消化管洗浄液中からの吸着特性について検討し、ポリエチレングリコールが活性炭へのアセトアミノフェン吸着を妨害していることを明らかにした。
  • 開発途上国における飲料水中の重金属イオン除去法  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫; 緒方 文彦; 中村 尚文
    第31回日本環境学会研究発表会  2005/06  札幌  第31回日本環境学会研究発表会
  • 数種の植物バイオマスによる鉛・鉄イオンの除去  [Not invited]
    中村 尚文; 棚田 成紀; 川﨑 直人; 中村 武夫
    第14回環境化学討論会  2005/06  大阪  第14回環境化学討論会
  • 富栄養化防止を指向したリン酸イオン回収用吸着剤の創製  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫; 中村 尚文
    第14回環境化学討論会  2005/06  大阪  第14回環境化学討論会
  • 賦活化竹炭によるインジゴカルミンの除去  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 前田 雄大
    日本薬学会第125年会  2005/03  東京  日本薬学会第125年会
  • 植物バイオマスによる鉛・鉄イオンの除去能  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫
    化学工学会第７０年会  2005/03  名古屋  化学工学会第７０年会
     
    植物バイオマスであるコーヒー豆かすおよびおからによる鉛イオンまたは鉄イオンの競合吸着について検討し、鉛イオンは鉄イオンに比べ吸着されやすいことが明らかになった。
  • 柚子搾り粕由来炭素材料によるコンゴーレッドの除去特性  [Not invited]
    中村 武夫; 棚田 成紀; 川﨑 直人; 田村 隆教; 内田 治
    第７５回日本衛生学会総会  2005/03  新潟  第７５回日本衛生学会総会
     
    有機性廃棄物である柚子搾り粕を炭化、炭化後水蒸気賦活したものへのコンゴーレッドの吸着特性について検討し、コンゴーレッドを効率よく除去できることが明らかになった。
  • 島津式体脂肪測定装置（BSF-200）による体脂肪測定値の評価について  [Not invited]
    青地 克頼; 棚田 成紀; 川﨑 直人; 中村 武夫; 大内 志織; 松本 和興; 大内; みどり
    第１２回日本健康体力栄養学会  2005/03  神戸  第１２回日本健康体力栄養学会
     
    島津式体脂肪測定装置（BSF-200）およびタニタ製インピーダンス式体組成系との相関性について検討し、両者の間には有意な差が認められた。
  • 中学生期における骨粗 症を目指した健康栄養教育的介入の効果の評価に関する研究  [Not invited]
    大内 みどり; 棚田 成紀; 川﨑 直人; 中村 武夫; 宮崎 富美子; 青地 克頼
    第12回日本健康体力栄養学会  2005/03  神戸  第12回日本健康体力栄養学会
     
    成長期にある中学生の骨密度とその関連要因に関する基礎的資料を得ることを目的に行い、身体活動は社会的要因に左右され、そのことが食生活要因よりも強く影響していることを明らかにした。
  • Development of water treatment technology by vegetable biomass  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫
    第21回エネルギーシステム・経済・環境コンファレンス  2005/01  東京  第21回エネルギーシステム・経済・環境コンファレンス
     
    植物バイオマスであるコーヒー豆かすによる鉛イオンの除去能について検討した。その結果、高効率で鉛イオンを除去できることが明らかになった。
  • Recycling use of food waste, the lees of YUZU(Citrus junos), as an adsorbent for dye  [Not invited]
    中村 武夫; 棚田 成紀; 川﨑 直人; 田村隆教
    2004年国際有機資源リサイクルシンポジウム秋田  2004/10  秋田  2004年国際有機資源リサイクルシンポジウム秋田
     
    ゆずの搾りかすにから炭素材料を製し、インジゴカルミンおよびオレンジIIの除去能について検討し、染料の除去用吸着剤として適用できることを明らかにした。
  • 鉛中毒防止を指向したコーヒー生豆による鉛イオンの除去  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫
    第63回日本公衆衛生学会総会  2004/10  松江  第63回日本公衆衛生学会総会
     
    植物バイオマスであるコーヒー生豆による鉛イオンの吸着能について検討し、焙煎後のコーヒー豆ますに比べ、鉛イオンの除去効率が高いことを明らかにした。
  • シックハウス症候群関連ホルムアルデヒドに対する精油成分マスキング効果  [Not invited]
    棚田 成紀; 川﨑 直人; 中村 武夫
    第６３回日本公衆衛生学会総会  2004/10  松江  第６３回日本公衆衛生学会総会
     
    化学物質過敏症原因物質となるホルムアルデヒドの除去効果について、竹炭、ハイクリンボード、精油成分などを用い、ジャスミン油により除去できる可能性が示唆された。
  • Production of adsorbents from soybean residue for indigo carmine removal  [Not invited]
    中村 武夫; 棚田 成紀; 川﨑 直人; 前田 雄大; 田村 隆教
    International Conference on Organic Recycling  2004/10  Hangzhou, China  International Conference on Organic Recycling
     
    有機性廃棄物のひとつであるオカラを原料に炭素材料を製し、染料であるインジゴカルミンを高効率で除去できることが明らかになった。
  • 腸管洗浄液中における活性炭へのアセトアミノフェンの吸着特性  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀
    第26回日本中毒学会総会  2004/07  広島  第26回日本中毒学会総会
  • 植物バイオマスによる重金属の除去に関する研究  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫; 時本 敏充
    化学工学会秋田大会  2004/07  秋田  化学工学会秋田大会
     
    植物バイオマスであるコーヒー豆かすによる数種の重金属イオンの除去能について検討し、重金属は競合吸着することが明らかになった。
  • シックハウス症候群防止を指向したリサイクルモデル住宅におけるホルムアルデヒド対策  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫; 時本 敏充
    第13回環境科学討論会  2004/07  静岡  第13回環境科学討論会
     
    オープンリサーチセンタープロジェクトにより建設されたリサイクルモデル住宅を用い、ほれ無アルデヒドの除去性能について検討し、ジャスミンオイルにより除去できることを明らかにした。
  • 水道水中鉛イオン完全除去のための7種吸着剤の性能  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫
    化学工学会第69年会  2004/04  大阪  化学工学会第69年会
     
    日本における水道管は鉛が使用されており、水道水には鉛イオンが混入していることが多い。したがって、7種類の吸着剤について検討した結果、植物バイオマスであるコーヒー豆かすが有益であることが明らかになった。
  • 中学生期における音響的踵骨・骨評価値と生活習慣および心理社会的要因に関する研究  [Not invited]
    大内みどり; 棚田 成紀; 川﨑 直人; 中村 武夫; 松本和興; 青地克頼
    第11回日本健康体力栄養研究会  2004/03  東京  第11回日本健康体力栄養研究会
     
    成長期にある中学生の骨密度とその関連要因に関する基礎的資料を得ることを目的に行い、身体活動は社会的要因に左右され、そのことが食生活要因よりも強く影響していることを明らかにした。
  • オカラ由来炭素材料によるインジゴカルミンの除去特性  [Not invited]
    中村 武夫; 前田 雄大; 川﨑 直人; 北小路 学; 棚田 成紀
    日本薬学会第124年会  2004/03  大阪  日本薬学会第124年会
  • Adsorption properties of CFC onto plasma-treated activated carbon  [Not invited]
    川﨑 直人; 棚田 成紀; 中村 武夫
    第２１回プラズマプロセシング研究会  2004/01  札幌  第２１回プラズマプロセシング研究会
     
    活性炭表面をフロンによりプラズマ処理し、吸着能について検討し、その結果、高効率で除去できることを明らかにした。
  • コーヒー豆抽出残渣由来炭化物の染色排水処理材としての利用に関する基礎的研究  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀; 松本 和興; 田村 隆教
    第62回日本公衆衛生学会総会  2003/10  京都  第62回日本公衆衛生学会総会
  • アセトアミノフェン除去に対する活性炭の効果的使用に関する基礎的研究  [Not invited]
    中村 武夫; 川﨑 直人; 棚田 成紀
    第25回日本中毒学会総会  2003/07  福島  第25回日本中毒学会総会
  • 食品廃棄物由来炭化物によるインジゴカルミンおよびビスフェノールＡの除去特性  [Not invited]
    中村 武夫; 川﨑 直人; 北小路 学; 棚田 成紀
    日本薬学会第123年会  2003/03  長崎  日本薬学会第123年会
  • Removal of noneylphenol by carbonous materials produced from cottonseed shell  [Not invited]
    棚田 成紀; 中村 武夫; 川﨑 直人; 安部郁夫; 岩
    日本薬学会第 121 年会 (札幌)  2001/03  日本薬学会第 121 年会 (札幌)
     
    製油産業における有機性副産物である綿実殻より炭素材料を製し､ それらによる 4 ノニルフェノールの除去特性について検討したものである｡

Works

  • 生活環境と諸障害発症に関する疫学的研究
    2003
  • 水環境中含窒素・リン化合物の吸着回収・除去技術の開発
    2003
  • 室内環境保全のための新規吸着剤の開発
    2003
  • 水道原水中環境ホルモンの高度処理
    2000 -2001
  • Ozone and Activated Carbon Treatment of Endocrine Disruptors
    2000 -2001
  • 有機性副産物の炭化による再資源化および炭素循環に関する研究
    2000
  • Studies on Carbon Circulation and Recycling by Carbonization of Organic By-Products
    2000

MISC

Industrial Property Rights

  • 特願2014-083172:粒子状リン吸着材 およびその製造方法  
    川﨑直人, 緒方文彦, 戸田 徳, 大谷 昌司

Awards & Honors

  • 2022/06 日本水環境学会 日本水環境学会功労賞
  • 2020/06 The Pharmaceutical Society of Japan The Most Published Author Award 2016-2020 Chemical and Pharmaceutical Bulletin
  • 2018/09 日本薬学会 日本薬学会 環境・衛生部会 学術賞
     
    受賞者: 川﨑 直人
  • 2018/06 日本抗加齢医学会 第18回日本抗加齢医学会総会 優秀演題賞
     
    受賞者: 川﨑 直人
  • 2009/01 日本表面科学会 e-JSSNT Paper of The Year 2008, Bronze Medal
     
    受賞者: 川﨑 直人
  • 2007/12 日本水環境学会関西支部 日本水環境学会関西支部水環境奨励賞
     
    受賞者: 川﨑 直人

Research Grants & Projects

  • 持続可能な開発のためのバイオマスを用いた希少金属（レアアース）の回収研究
    科学研究費助成事業：基盤研究（Ｃ）
    Date (from‐to) : 2015/04 -2018/03 
    Author : 川﨑 直人
  • 若年期からの生活習慣病予防を目指した健康意識向上システムの構築
    公益財団法人 健康科学財団：研究助成
    Date (from‐to) : 2015/06 -2016/03 
    Author : 川﨑 直人
  • 吸着剤を用いた油脂の変敗抑制技術と抗酸化能を有するブレンド油脂の開発
    一般財団法人 旗影会：研究助成
    Date (from‐to) : 2015/06 -2016/03 
    Author : 川﨑 直人
  • 簡易懸濁法に使用される薬剤と水道水中の金属イオン との相互作用
    公益財団法人 クリタ水・環境科学振興財団：国内研究助成
    Date (from‐to) : 2008/04 -2009/03 
    Author : 川﨑 直人
  • 浄化槽からのアルミニウム系吸着剤によるリン酸の連続回収に関する研究
    公益財団法人 日本環境整備教育センター：浄化槽に関する調査研究助成
    Date (from‐to) : 2007/04 -2008/03 
    Author : 川﨑 直人
  • 開発途上国における健康指標調査
    Date (from‐to) : 2004
  • 飲料水中重金属の除去技術の開発
    Date (from‐to) : 2003
  • 吸着剤の開発
  • プラズマ処理活性炭への有機性ハロゲン化合物の吸着特性
  • Development of adsorbents
  • Removal Environmental Hormones onto Inclusion-Adsorption composite
  • Adsorption Characteristics of Chlorinated Hydrocarbons on Plasma-Treated Activated Carbon
  • Studies on Technology for the Recovery of Chlorofluoro Carbon (CFC) Replacements

Teaching Experience

  • Life Environmental ScienceLife Environmental Science Kindai University

Other link

researchmap


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