KINDAI UNIVERSITY


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ITOH Kimihisa

Profile

FacultyExperimental Farms
PositionLecturer
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/1206-itou-kimihisa.html
URLhttp://www.kindai.ac.jp/farm/
Mail
Last Updated :2020/09/03

Research Activities

Research Interests

  • Lifestyle diseases, melanin, skin whitening

Published Papers

  • Inhibition of advanced glycation end products formation by Mangifera indica leaf extract, Itoh K, Murata K, Sakaguchi N, Akai K, Yamaji T, Shimizu K, Isaki K, Matsukawa T, Kajiyama S, Fumuro M, Iijima M, Matsuda H, Journal of plant studies, Journal of plant studies, 6(2), 102 - 107, Aug. 2017 , Refereed
  • Inhibitory activity of Citrus madurensis ripe fruits extract on antigen-induced degranulation in RBL-2H3 cells, Itoh K, Murata K, Futamura-Masuda M, Deguchi T, Ono Y, Eshita M, Fumuro M, Iijima M, Matsuda H, Journal of plant studies, Journal of plant studies, 6(1), 23 - 30, 2017 , Refereed
  • A pancreatic lipase inhibitory activity by Mango (Mangifera indica) leaf methanolic extract, Itoh K, Murata K, Nakagaki Y, Shimizu A, Takata Y, Shimizu K, Matsukawa T, Kajiyama S, Fumuro M, Iijima M, Matsuda H, Journal of plant studies, Journal of plant studies, 5(2), 72 - 78, 2016 , Refereed
  • Combined effect of lysed Enterococcus faecalis FK-23 and fruits of Citrus unshiu on contact dermatitis in mice, Nishikawa K, Shimada T, Hayashi A, Okamori M, Fukuda K, Goshima A, Itoh K, Murata K, Matsuda H, Pharmacometrics, Pharmacometrics, 90(5-6), 95 - 99, 2016 , Refereed
  • In vitro Antioxidant Activity of Mangifera indica Leaf Extracts, Kimihisa Itoh, Tetsuya Matsukawa, Mamoru Okamoto, Kanasa Minami, Norimichi Tomohiro, Kosuke Shimizu, Shin’ichiro Kajiyama, Yuichi Endo, Hideaki Matsuda, Shigeru Shigeoka, Journal of Plant Studies, Journal of Plant Studies, 9(2), 39 - 45, Jun. 26 2020 , Refereed
  • Inhibitory Effect of Several Mangifera indica Cultivar Leaf Extracts on the Formation of Advanced Glycation End Products (AGEs), Kimihisa Itoh, Tetsuya Matsukawa, Kanasa Minami, Mamoru Okamoto, Norimichi Tomohiro, Kosuke Shimizu, Shin’ichiro Kajiyama, Yuichi Endo, Hideaki Matsuda, Shigeru Shigeoka, Journal of Plant Studies, Journal of Plant Studies, 9(2), 33 - 38, May 26 2020 , Refereed
  • Pancreatic Lipase Inhibitory Activity of Citrus unshiu Leaf Extract, Kimihisa Itoh, Tetsuya Matsukawa, Kazuya Murata, Ryota Nishitani, Momona Yamagami, Norimichi Tomohiro, Shin'ichiro Kajiyama, Masahiko Fumuro, Morio Iijima, Shigeru Shigeoka, Yuichi Endo, Hideaki Matsuda, Natural Product Communications, Natural Product Communications, 14(9), 1934578X1987343 - 1934578X1987343, Sep. 2019 , Refereed
    Summary:In the cultivation of Citrus fruit, pruning in late winter after harvest is important to obtain excellent flower buds in the next spring and a rich harvest of superior fruit in the following winter; a large number of pruned leaves are usually discarded. The purpose of this study was to determine the utility value of pruned leaves of Citrus unshiu. A methanol extract of pruned C. unshiu leaves showed a porcine pancreatic lipase inhibitory activity. Fractionation of C. unshiu leaf extract (CUL-ext) followed by bibliographic and chromatographic analyses revealed that a part of the pancreatic lipase inhibitory activity of CUL-ext was attributable to nobiletin (1), rutin (2), and hesperidin (3). Thus, pruned C. unshiu leaves may be a reasonable natural resource for the preparation of ingredients with lipase inhibitory activity.
  • Search for Skin-whitening Agent from Prunus Plants and the Molecular Targets in Melanogenesis Pathway of Active Compounds, Kazuya Murata, Keisuke Takahashi, Haruka Nakamura, Kimihisa Itoh, Hideaki Matsuda, NATURAL PRODUCT COMMUNICATIONS, NATURAL PRODUCT COMMUNICATIONS, 9(2), 185 - 188, Feb. 2014 , Refereed
    Summary:In our research program for discovering novel skin-whitening materials, screening of extracts from flowers of some Prunus species was performed using an anti-tyrosinase assay. Among the tested plants, the flowers of P. persica showed the most potent inhibitory activity. In addition, P. persica also showed suppression of melanogenesis in B16 rat melanoma cells. The active principles of tyrosinase inhibition and suppression of melanogenesis were revealed to be an afzelin (3-O-alpha-L-rhamnosylkaempferol) and a flavanone, naringenin. The mechanism of the anti-melanogenesis effect of these two compounds was disclosed, for the first time, as the suppression of the expression of tyrosinase protein, which was controlled by the inhibition of phosphorylation of p38 MAPK. These findings show that these compounds could be candidates for the novel molecular target for a skin-whitening agent.
  • Inhibitory Effects of Morinda citrifolia Extract and Its Constituents on Melanogenesis in Murine B16 Melanoma Cells, Megumi Masuda, Kimihisa Itoh, Kazuya Murata, Shunsuke Naruto, Akemi Uwaya, Fumiyuki Isami, Hideaki Matsuda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(1), 78 - 83, Jan. 2012 , Refereed
    Summary:The objective of this study was to examine the effects of Morinda citrifolia (noni) extract and its constituents on a-melanocyte stimulating hormone (alpha-MSH)-stimulated melanogenesis in cultured murine B16 melanoma cells (B16 cells). A 50% ethanolic extract of noni seeds (MCS-ext) showed significant inhibition of melanogenesis with no effect on cell proliferation. MCS-ext was more active than noni leaf and fruit flesh extracts. Activity guided fractionation of MCS-ext led to the isolation of two lignans, 3,3'-bisdemethylpinoresinol (1) and americanin A (2), as active constituents. To elucidate the mechanism of melanogenesis inhibition by the lignans, alpha-MSH-stimulated B16 cells were treated with 1 (5 mu m) and 2 (200 mu m). Time-dependent increases of intracellular melanin content and tyrosinase activity, during 24 to 72h, were inhibited significantly by treatment with the lignans. The activity of 1 was greater than that of 2. Western blot analysis suggested that the lignans inhibited melanogenesis by down regulation of the levels of phosphorylation of p38 mitogen-activated protein kinase, resulting in suppression of tyrosinase expression.
  • Xanthine Oxidase Inhibitory Activities and Crystal Structures of Methoxyflavones from Kaempferia parviflora Rhizome, Kikuyo Nakao, Kazuya Murata, Takahiro Deguchi, Kimihisa Itoh, Takanori Fujita, Masayuki Higashino, Yuri Yoshioka, Shin-ichi Matsumura, Rika Tanaka, Tetsuro Shinada, Yasufumi Ohfune, Hideaki Matsuda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 34(7), 1143 - 1146, Jul. 2011 , Refereed
    Summary:Kaempferia parviflora (KP), a Zingiberaceae plant, is used as a folk medicine in Thailand for the treatment of various symptoms, including general pains, colic gastrointestinal disorders, and male impotence. In this study, the inhibitory activities of KP against xanthine oxidase (XOD) were investigated. The extract of KP rhizomes showed more potent inhibitory activity (38% at 500 mu g/ml) than those of the other Zingiberaceae plants tested. Ten methoxyflavones were isolated from the KP extract as the major chemical components and their chemical structures were elucidated by X-ray crystallography. The structurally confirmed methoxyflavones were subjected to the XOD inhibitory test. Among them, 3,5,7,4',5'-pentamethoxyflavone and 3',4',5,7-tetramethoxyflavone showed inhibitory activities (IC50 of 0.9 and >4 mM, respectively) and their modes of inhibition are clarified as competitive/non-competitive mixed type. To the best of our knowledge, this is the first report to present the inhibitory activities of KP, 3,5,7,4',5'-pentamethoxyflavone and 3',4',5,7-tetramethoxyflavone against XOD.
  • Effects of Morinda citrifolia extract and its constituents on blood fluidity, Megumi Masuda, Kazuya Murata, Kimihisa Itoh, Shunsuke Naruto, Akemi Uwaya, Fumiyuki Isami, Hideaki Matsuda, Journal of Traditional Medicines, Journal of Traditional Medicines, 28(2), 47 - 54, 2011 , Refereed
    Summary:Functional foods derived from noni (Morinda citrifolia) have been marketed to help prevent lifestyle-related diseases. Many lifestyle-related diseases, such as hypertension and hyperlipemia, are associated with poor blood fluidity. The objective of this study was to examine the effect of 50% ethanolic extracts from noni, and their constituents, on blood fluidity, in a lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) rat model with a micro channel array flow analyzer (MC-FAN). Oral administrations of the noni leaf extract (MCL-ext) and the noni seed extract (MCS-ext) to DIC rats resulted in a reduction of the passage time of whole blood, as compared to the vehicle control. The MCL-ext and its constituents, namely ursolic acid (1), rutin (2), and kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (3) inhibited collagen-induced platelet aggregation. MCL-ext, as well as MCS-ext and its constituents, namely 1, americanin A (4), and 3, 3′-bisdemethylpinoresinol (5), inhibited polybrene-induced erythrocyte aggregation. Inhibition of erythrocyte aggregation by MCL-ext and MCS-ext was mainly attributable to 1. The euglobulin lysis time (ELT) assay indicated that oral administration of MCL-ext or MCS-ext induces fibrinolysis activity in rats. This is the first report of the effects of noni extracts on blood fluidity. MCL-ext exhibited more in vitro anti-platelet activity, and improvement of blood fluidity and fibrinolysis activity in vivo than MCS-ext. © 2011, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.
  • Anti-hyperuricemia effects of extracts of immature Citrus unshiu fruit, Kikuyo Nakao, Kazuya Murata, Kimihisa Itoh, Yuko Hanamoto, Megumi Masuda, Kenzo Moriyama, Takahiro Shintani, Hideaki Matsuda, Journal of Traditional Medicines, Journal of Traditional Medicines, 28(1), 10 - 15, 2011 , Refereed
    Summary:In our search for novel materials possessing anti-hyperuricemic effects, we examined immature Citrus unshiu fruit. Extracts of immature C. unshiu fruit showed moderate anti-hyperuricemic effects in a hyperuricemic model the extract reduced increased serum urate level by 36% at 500 mg/kg, p.o. The extract did not show significant xanthine oxidase inhibitory activity, but the metabolite of the main flavanone glycoside in the fruit, hesperetin, showed potent anti-hyperuricemic effects hesperetin reduced increased serum urate level by 44% at 200 mg/kg, p.o. Furthermore, hesperetin showed dose-dependent xanthine oxidase inhibitory activity of 52% at 200 μM. Thus, the anti-hyperuricemic effects of immature C. unshiu may be attributed to hesperetin, a metabolite of hesperidin via xanthine oxidase inhibition. © 2011, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.
  • Effects of Unripe Citrus hassaku Fruits Extract and Its Flavanone Glycosides on Blood Fluidity, Kimihisa Itoh, Megumi Masuda, Shunsuke Naruto, Kazuya Murata, Hideaki Matsuda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(4), 659 - 664, Apr. 2010 , Refereed
    Summary:The enhancement of blood fluidity may lead to improvements in skin problems resulting from unsmooth circulation or blood stagnation. Since a 50% ethanolic extract (CH-ext) obtained from unripe Citrus hassaku fruits may be a useful ingredient in skin-whitening cosmetics, the present study was designed to examine the effect of CH-ext on blood fluidity. CH-ext concentration-dependently inhibited in vitro collagen-induced rabbit platelet aggregation and in vitro polybrene-induced rat erythrocyte aggregation. The CH-ext showed in vitro fibrinolysis activity in fibrin plate assay. Activity-guided fractionation of the CH-ext using antiplatelet activity, inhibitory activity of erythrocyte aggregation, and fibrinolysis activity revealed that these activities of CH-ext were attributable to naringenin-7-glycoside (prunin). Successive oral administration of CH-ext to rats inhibited the lipopolysaccharide (LPS)-induced decrease of blood platelets and fibrinogen, and LPS-induced increase of fibrin degradation products (FDP) in LPS-induced disseminated intravascular coagulation (DIC) model rats. Effects of CH-ext on blood fluidity were analyzed by a micro channel array flow analyzer (MC-FAN). Preventive oral administration of CH-ext to rats showed dose-dependent reduction of the passage time of whole blood flow of the DIC model rats in comparison with that of the vehicle control rats. These results imply that CH-ext may have effects which improve effects on blood fluidity.
  • Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice, Kimihisa Itoh, Megumi Masuda, Shunsuke Naruto, Kazuya Murata, Hideaki Matsuda, JOURNAL OF NATURAL MEDICINES, JOURNAL OF NATURAL MEDICINES, 63(4), 443 - 450, Oct. 2009 , Refereed
    Summary:Oral administration of a 50% ethanolic extract (CH-ext) obtained from unripe Citrus hassaku fruits collected in July exhibited a potent dose-dependent inhibition of IgE (immunoglobulin E)-mediated triphasic cutaneous reaction at 1 h [immediate phase response (IPR)], 24 h [late phase response (LPR)] and 8 days [very late phase response (vLPR)] after dinitrofluorobenzene challenge in mice. Naringin, a major flavanone glycoside component of CH-ext, showed a potent dose-dependent inhibition against IPR, LPR and vLPR. Neohesperidin, another major glycoside component of CH-ext, showed an inhibition against vLPR. The effect of CH-ext on type IV allergic reaction was examined by determining inhibitory activity against ear swelling in mice by using the picryl chloride-induced contact dermatitis (PC-CD) model. Oral administration (p.o.) of CH-ext and subcutaneous administration (s.c.) of prednisolone inhibited ear swelling during the induction phase of PC-CD. The inhibitory activities of combinations of CH-ext (p.o.) and prednisolone (s.c.) against PC-CD in mice were more potent than those of CH-ext alone and prednisolone alone, without enhancing the adverse effects. Other combinations of prednisolone (s.c.) and flavanone glycoside (p.o.) components of CH-ext, i.e. naringin and neohesperidin, exerted similar synergistic effects.
  • Inhibitory Effects of Citrus hassaku Extract and Its Flavanone Glycosides on Melanogenesis, Kimihisa Itoh, Noriko Hirata, Megumi Masuda, Shunsuke Naruto, Kazuya Murata, Keitaro Wakabayashi, Hideaki Matsuda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 32(3), 410 - 415, Mar. 2009 , Refereed
    Summary:The 50% ethanolic extract (CH-ext) obtained from the unripe fruit of Citrus hassaku exhibited significant tyrosinase inhibitory activity. The CH-ext showed antioxidant activity, such as superoxide dismutase (SOD)-like activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity. Activity-guided fractionation of the CH-ext indicated that flavanone glycoside-rich fractions showed potent tyrosinase inhibitory activity. Further examination revealed that the tyrosinase inhibitory activity and antioxidant activity of the CH-ext were attributable to naringin and neohesperidin, respectively. The CH-ext showed inhibition of melanogenesis without any effects on cell proliferation in cultured murine B16 melanoma cells after glucosamine exposure. The topical application of the CH-ext to the dorsal skin of brownish guinea pigs showed in vivo preventive effects against UVB-induced pigmentation.
  • Fibrinolytic activity of ligustilide and pharmaceutical comparison of angelica acutiloba roots before and after processing in hot water, Kozo Fukuda, Kazuya Murata, Kimihisa Itoh, Hideaki Matsuda, Masahiko Taniguchi, Makio Shibano, Kimiye Baba, Makoto Shiratori, Tadato Tani, Journal of Traditional Medicines, Journal of Traditional Medicines, 26(42496), 210 - 218, 2009
    Summary:The dried roots of Angelica acutiloba (Yamato-toki in Japanese) are an important crude drug component of traditional Chinese prescriptions used to improve menopausal symptoms. The improvement in blood circulation by Yamato-toki was revealed by the oral administration of (Z)-ligustilide, a major ingredient of Yamato-toki, which showed significant shortening of euglobulin lysis time. This is the first report to reveal fibrinolytic activity of (Z)-ligustilide. Furthermore, ferulic acid and adenosine were two active ingredients with antiplatelet, antierythrocyte aggregation, and fibrinolytic activities. A. acutiloba roots are processed into Yamato-toki by Yumomi treatment, which is a traditional processing procedure involving blanching in hot water. Methanol extracts of A. acutiloba roots with or without Yumomi treatment showed similar dose-dependent and significant antierythrocyte aggregation activities. There was no discernable difference in the (Z)-ligustilide, ferulic acid, and adenosine contents between A. acutiloba roots with or without Yumomi treatment. Sugar analysis results indicated that Yumomi processing increases the monosaccharide content, which enhances sweetness. The results showed that (Z)-ligustilide was a fibrinolytic activator. However, there was no enhancement of biological activity following Yumomi treatment. Thus, Yumomi is utilized mainly to improve appearance and quality, as evaluated by sensory tests, and to enhance sweetness and brownish color rather than raising the contents of ingredients. © 2009, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.
  • Histamine release inhibitory activity of Piper nigrum leaf, Noriko Hirata, Shunsuke Naruto, Kazunori Inaba, Kimihisa Itoh, Masashi Tokunaga, Munekazu Iinuma, Hideaki Matsuda, BIOLOGICAL & PHARMACEUTICAL BULLETIN, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 31(10), 1973 - 1976, Oct. 2008 , Refereed
    Summary:Oral administration of a methanolic extract of Piper nigrum leaf (PN-ext, 50, 200 and 500 mg/kg) showed a potent dose-dependent inhibition of dinitrofluorobenzene (DNFB)-induced cutaneous reaction at I h [immediate phase response (IPR)] after and 24 h [late phase response (LPR)] after DNFB challenge in mice which were passively sensitized with anti-dinitrophenyl (DNP) IgE antibody. Ear swelling inhibitory effect ot PN-ext (50, 200 and 500 mg/kg, per os (p.o.)) on very late phase response (vLPR) in the model mice was significant but weaker than that on IPR. Oral administration of PN-ext (50, 200 and 501) mg/kg for 7 d) inhibited picryl chloride (PC)-induced ear swelling in PC sensitized mice. PN-ext exhibited in vitro inhibitory effect on compound 48/80-induced histamine release from rat peritoneal mast cells. Two lignans of PN-ext, (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), were identified as major active principles having histamine release inhibitory activity.
  • Pharmacological study on Panax ginseng C. A. Meyer. XVI. Improving effects of Red Ginseng on peripheral circulation disorder, Yasuyuki Tsukioka, Kikuyo Nakao, Kenzo Moriyama, Takahiro Shintani, Keiichi Samukawa, Kimihisa Itoh, Fumiaki Takeshita, Hideaki Matsuda, Journal of Traditional Medicines, Journal of Traditional Medicines, 25(2), 43 - 51, 2008
    Summary:The improving effects of 70% methanol extract (RG-ext) and its potent components obtained from Red Ginseng on the peripheral circulation disorder were investigated using various experimental models in rats. RG-ext promoted the dorsal skin blood flow of intact rat and improved the lowering of the dorsal skin blood flow induced by norepinephrine (NE), and also caused by water immersion, but was ineffective on serotonin-treated rats. RG-ext restored the increase of the blood flow induced by doxazosin (DO). Ginsenoside-Rb1 (Rb1) improved the lowering of the dorsal skin blood flow by NE and ginsenoside-Rg1 (Rg1) restored the increase of blood flow by DO. When Rb1 was administered orally to rats in combination with non-saponin fraction (RW-fr) obtained from Red Ginseng, the improving effects were more enhanced than that of Rb1 alone, but it was ineffective in RW-fr itself. Non-saponin fraction (WW-fr) from White Ginseng did not show the increasing effect such a RW-fr. Rb1 produced 20(S)- and 20(R)-ginsenoside-Rg3 [20(S)- and 20(R)-Rg3] in gastric juice, and in artificial gastric juice. Ginsenoside-Rb2, -Rc and -Rd also produced 20(S)- and 20(R)-Rg3 as well as Rb1. When 20(S)-Rg3 was administered intravenously to rats, it improved the lowering of the dorsal skin blood flow induced by NE, but only showed a tendency to improve the blood flow in case of oral administration. 20(S)-Rg3 showed relatively strong improving effect in combination with RW-fr. Consequently, it has become apparent that the improving effect of RG-ext on the peripheral circulation disorder are attributable to action of 20(S)-Rg3 which was formed from protopanaxadiol saponins of RG-ext in stomach and then absorbed into blood flow through intestinal membrane with some support of RW-fr. © 2008, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.

Conference Activities & Talks

  • Development of unused natural resources for functional materials-A pancreatic lipase inhibitory activity by methanolic extract from Citrus unshiu flower-, Kimihisa Itoh,   2018 03
  • Skin-whitening effect of extract from fruits of Citrus hassaku and its flavonoids., 2010 International Chemical Congress of Pacific Basin Societies,   2010 12

Misc

  • 未利用農産資源の機能性素材としての開発研究―ウンシュウミカン花のリパーゼ阻害作用―, 伊藤仁久, 村田和也, 山上桃奈, 松川哲也, 松川哲也, 梶山慎一郎, 文室政彦, 飯嶋盛雄, 飯嶋盛雄, 松田秀秋, 松田秀秋, 日本薬学会年会要旨集(CD-ROM), 138th, ROMBUNNO.27PA‐pm242,   2018 , http://jglobal.jst.go.jp/public/201802244390124894
  • 未利用農産資源の機能性素材としての開発研究―マンゴー葉のリパーゼ阻害作用―, 伊藤仁久, 村田和也, 中垣友太, 清水彩加, 高田雄輔, 志水恒介, 松川哲也, 松川哲也, 梶山慎一郎, 文室政彦, 飯嶋盛雄, 飯嶋盛雄, 松田秀秋, 松田秀秋, 日本薬学会年会要旨集(CD-ROM), 137th, ROMBUNNO.26PA‐am026,   2017 , http://jglobal.jst.go.jp/public/201702282783195829
  • 未利用農産資源の機能性素材としての開発研究―マンゴー葉の美白作用―, 伊藤仁久, 志水恒介, 堀川勇次, 友廣教道, 文室政彦, 宇都宮直樹, 飯嶋盛雄, 高田雄輔, 松川哲也, 松川哲也, 梶山慎一郎, 赤井康平, 中垣友太, 村田和也, 松田秀秋, 松田秀秋, 日本生薬学会年会講演要旨集, 62nd, 102,   2015 08 31 , http://jglobal.jst.go.jp/public/201602254709799901
  • ウンシュウミカン(Citrus unshiu)葉のリパーゼ阻害活性物質, TAKATA YUSUKE, MATSUKAWA TETSUYA, ITO KIMIHISA, SHIMIZU KOSUKE, HORIKAWA YUJI, TOMOHIRO NORIMICHI, TSUMOTO TERUYOSHI, HASHIZUME JUNJI, FUJITA TAKUYA, FUMIMURO MASAHIKO, UTSUNOMIYA NAOKI, NAKAGAKI YUTA, MURATA KAZUYA, MATSUDA HIDEAKI, KAJIYAMA SHIN'ICHIRO, 日本農芸化学会大会講演要旨集(Web), 2015, 3F37A15 (WEB ONLY),   2015 03 05 , http://jglobal.jst.go.jp/detail.php?from=API&JGLOBAL_ID=201502283903737507
  • カンキツ植物の生活習慣病に対する有効性に関する研究―ウンシュウミカン(Citrus unshiu)葉の抗肥満作用について, ITO KIMIHISA, SHIMIZU KOSUKE, HORIKAWA YUJI, TOMOHIRO NORIMICHI, TSUMOTO MITSUTAKA, HASHIZUME JUNJI, FUJITA TAKUYA, FUMURO MASAHIKO, UTSUNOMIYA NAOKI, TAKADA YUSUKE, MATSUKAWA TETSUYA, MATSUKAWA TETSUYA, KAJIYAMA SHIN'ICHIRO, NAKAGAKI TOMOTA, MURATA KAZUYA, MATSUDA HIDEAKI, MATSUDA HIDEAKI, 日本薬学会年会要旨集(CD-ROM), 135th, ROMBUNNO.27PB-AM159,   2015 , http://jglobal.jst.go.jp/detail.php?from=API&JGLOBAL_ID=201502295752084393
  • Novel functions of Japanese unique Citrus fruits discovered from their historical aspects, 松田 秀秋, 伊藤 仁久, 増田 めぐみ, 香料, 247, 63, 71,   2010 , http://ci.nii.ac.jp/naid/40017317590