藤田 裕規 (フジタ ユウキ)

  • 医学科 講師・兼任教員
Last Updated :2024/03/24

コミュニケーション情報 byコメンテータガイド

  • コメント

    生活習慣病予防のための疫学研究を行っている。妊娠前や胎児期から小児期の発育環境に着目し、どのような発育環境が生活習慣病の引き金となっているのかについて研究している。

研究者情報

学位

  • 博士(2006年09月 医学)

ホームページURL

J-Global ID

現在の研究分野(キーワード)

    生活習慣病予防のための疫学研究を行っている。妊娠前や胎児期から小児期の発育環境に着目し、どのような発育環境が生活習慣病の引き金となっているのかについて研究している。

研究分野

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

学歴

  • 1998年04月 - 2000年03月   九州大学大学院薬学専攻
  •         - 2000年   九州大学   Graduate School, Division of Pharmaceutical Sciences
  •         - 1997年   第一薬科大学   Faculty of Pharmaceutical Science

所属学協会

  • 日本計量生物学会   日本生理人類学会   日本骨代謝学会   日本骨粗鬆症学会   日本学校保健学会   日本疫学会   日本公衆衛生学会   

研究活動情報

論文

  • Kumiko Ohara; Harunobu Nakamura; Katsuyasu Kouda; Yuki Fujita; Tomoki Mase; Katsumasa Momoi; Toshimasa Nishiyama
    Scientific reports 13 1 17420 - 17420 2023年10月 
    A variety of easy-to-use commercial bioelectrical impedance appliances are available. The aim of this study was to examine the usefulness of a commercially available body composition meter using bioelectrical impedance analysis (BIA) by comparing its measurement results with those obtained from dual-energy X-ray absorptiometry (DXA). The participants were 443 children aged from 10 to 14 years (226 boys and 217 girls). Fat mass, fat-free mass, lean body mass, percentage of body fat, and bone mineral contents were evaluated for all participants using BIA and DXA. The agreement in the anthropometric data obtained from both devices was analyzed using correlation analysis, intraclass correlation coefficient (ICC), Lin's concordance correlation coefficient (CCC), Bland-Altman plots, and ordinary least products regression analysis. Equivalence between both devices was tested by two one-sided t-test. All measured indicators showed strong linear correlations between the two measurement systems (r, 0.853-1.000). Fat mass, fat-free mass, and lean body mass showed absolute concordance (ICC, 0.902-0.972; Lin's CCC, 0.902-0.972). BIA overestimated bone mineral content (62.7-66.5%) and underestimated percentage of body fat (- 8.9 to - 0.8%), lean body mass (- 3.5 to - 1.8%), and body mass (- 0.8 to - 0.5%). For fat mass and fat-free mass, the overestimate or underestimate varied according to the sex and statistical analysis test. Bland-Altman analysis and ordinary least products analysis showed fixed bias and proportional bias in all indicators. Results according to quartiles of body mass index showed poor agreement for fat mass and percentage of body fat in both boys and girls in the lowest body mass index quartile. The present results revealed strong linear correlations between BIA and DXA, which confirmed the validity of the present single-frequency BIA-derived parameters. Our results suggest that BIA cannot provide the exact same values as DXA for some body composition parameters, but that performance is sufficient for longitudinal use within an individual for daily health management and monitoring.
  • J A Kanis; H Johansson; E V McCloskey; E Liu; K E Åkesson; F A Anderson; R Azagra; C L Bager; C Beaudart; H A Bischoff-Ferrari; E Biver; O Bruyère; J A Cauley; J R Center; R Chapurlat; C Christiansen; C Cooper; C J Crandall; S R Cummings; J A P da Silva; B Dawson-Hughes; A Diez-Perez; A B Dufour; J A Eisman; P J M Elders; S Ferrari; Y Fujita; S Fujiwara; C-C Glüer; I Goldshtein; D Goltzman; V Gudnason; J Hall; D Hans; M Hoff; R J Hollick; M Huisman; M Iki; S Ish-Shalom; G Jones; M K Karlsson; S Khosla; D P Kiel; W-P Koh; F Koromani; M A Kotowicz; H Kröger; T Kwok; O Lamy; A Langhammer; B Larijani; K Lippuner; D Mellström; T Merlijn; A Nordström; P Nordström; T W O'Neill; B Obermayer-Pietsch; C Ohlsson; E S Orwoll; J A Pasco; F Rivadeneira; A-M Schott; E J Shiroma; K Siggeirsdottir; E M Simonsick; E Sornay-Rendu; R Sund; K M A Swart; P Szulc; J Tamaki; D J Torgerson; N M van Schoor; T P van Staa; J Vila; N J Wareham; N C Wright; N Yoshimura; M C Zillikens; M Zwart; L Vandenput; N C Harvey; M Lorentzon; W D Leslie
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2023年08月 
    UNLABELLED: A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX. INTRODUCTION: The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD). METHODS: We studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19.5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Covariates examined were age, sex, BMD, and duration of follow-up. The results of the different studies were merged by using the weighted β-coefficients. RESULTS: A previous fracture history, compared with individuals without a prior fracture, was associated with a significantly increased risk of any clinical fracture (hazard ratio, HR = 1.88; 95% CI = 1.72-2.07). The risk ratio was similar for the outcome of osteoporotic fracture (HR = 1.87; 95% CI = 1.69-2.07), major osteoporotic fracture (HR = 1.83; 95% CI = 1.63-2.06), or for hip fracture (HR = 1.82; 95% CI = 1.62-2.06). There was no significant difference in risk ratio between men and women. Subsequent fracture risk was marginally downward adjusted when account was taken of BMD. Low BMD explained a minority of the risk for any clinical fracture (14%), osteoporotic fracture (17%), and for hip fracture (33%). The risk ratio for all fracture outcomes related to prior fracture decreased significantly with adjustment for age and time since baseline examination. CONCLUSION: A previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by BMD. The effect is similar in men and women. Its quantitation on an international basis permits the more accurate use of this risk factor in case finding strategies.
  • Anu Mishra; Bin Zhou; Andrea Rodriguez-Martinez; Honor Bixby; Rosie K. Singleton; Rodrigo M. Carrillo-Larco; Kate E. Sheffer; Christopher J. Paciorek; James E. Bennett; Victor Lhoste; Maria L. C. Iurilli; Mariachiara Di Cesare; James Bentham; Nowell H. Phelps; Marisa K. Sophiea; Gretchen A. Stevens; Goodarz Danaei; Melanie J. Cowan; Stefan Savin; Leanne M. Riley; Edward W. Gregg; Wichai Aekplakorn; Noor Ani Ahmad; Jennifer L. Baker; Adela Chirita-Emandi; Farshad Farzadfar; Günther Fink; Mirjam Heinen; Nayu Ikeda; Andre P. Kengne; Young-Ho Khang; Tiina Laatikainen; Avula Laxmaiah; Jun Ma; Michele Monroy-Valle; Malay K. Mridha; Cristina P. Padez; Andrew Reynolds; Maroje Sorić; Gregor Starc; James P. Wirth; Leandra Abarca-Gómez; Ziad A. Abdeen; Shynar Abdrakhmanova; Suhaila Abdul Ghaffar; Hanan F. Abdul Rahim; Zulfiya Abdurrahmonova; Niveen M. Abu-Rmeileh; Jamila Abubakar Garba; Benjamin Acosta-Cazares; Ishag Adam; Marzena Adamczyk; Robert J. Adams; Seth Adu-Afarwuah; Kaosar Afsana; Shoaib Afzal; Valirie N. Agbor; Imelda A. Agdeppa; Javad Aghazadeh-Attari; Hassan Aguenaou; Carlos A. Aguilar-Salinas; Charles Agyemang; Mohamad Hasnan Ahmad; Ali Ahmadi; Naser Ahmadi; Nastaran Ahmadi; Imran Ahmed; Soheir H. Ahmed; Wolfgang Ahrens; Gulmira Aitmurzaeva; Kamel Ajlouni; Hazzaa M. Al-Hazzaa; Badreya Al-Lahou; Rajaa Al-Raddadi; Huda M. Al Hourani; Nawal M. Al Qaoud; Monira Alarouj; Fadia AlBuhairan; Shahla AlDhukair; Maryam A. Aldwairji; Sylvia Alexius; Mohamed M. Ali; Abdullah Alkandari; Ala’a Alkerwi; Buthaina M. Alkhatib; Kristine Allin; Mar Alvarez-Pedrerol; Eman Aly; Deepak N. Amarapurkar; Pilar Amiano Etxezarreta; John Amoah; Norbert Amougou; Philippe Amouyel; Lars Bo Andersen; Sigmund A. Anderssen; Odysseas Androutsos; Lars Ängquist; Ranjit Mohan Anjana; Alireza Ansari-Moghaddam; Elena Anufrieva; Hajer Aounallah-Skhiri; Joana Araújo; Inger Ariansen; Tahir Aris; Raphael E. Arku; Nimmathota Arlappa; Krishna K. Aryal; Nega Aseffa; Thor Aspelund; Felix K. Assah; Batyrbek Assembekov; Maria Cecília F. Assunção; May Soe Aung; Juha Auvinen; Mária Avdičová; Shina Avi; Ana Azevedo; Mohsen Azimi-Nezhad; Fereidoun Azizi; Mehrdad Azmin; Bontha V. Babu; Maja Bæksgaard Jørgensen; Azli Baharudin; Suhad Bahijri; Marta Bakacs; Nagalla Balakrishna; Yulia Balanova; Mohamed Bamoshmoosh; Maciej Banach; José R. Banegas; Joanna Baran; Rafał Baran; Carlo M. Barbagallo; Valter Barbosa Filho; Alberto Barceló; Maja Baretić; Amina Barkat; Joaquin Barnoya; Lena Barrera; Marta Barreto; Aluisio J. D. Barros; Mauro Virgílio Gomes Barros; Anna Bartosiewicz; Abdul Basit; Joao Luiz D. Bastos; Iqbal Bata; Anwar M. Batieha; Aline P. Batista; Rosangela L. Batista; Zhamilya Battakova; Louise A. Baur; Pascal M. Bayauli; Robert Beaglehole; Silvia Bel-Serrat; Antonisamy Belavendra; Habiba Ben Romdhane; Judith Benedics; Mikhail Benet; Gilda Estela Benitez Rolandi; Elling Bere; Ingunn Holden Bergh; Yemane Berhane; Salim Berkinbayev; Antonio Bernabe-Ortiz; Gailute Bernotiene; Ximena Berrios Carrasola; Heloísa Bettiol; Manfred E. Beutel; Augustin F. Beybey; Jorge Bezerra; Aroor Bhagyalaxmi; Sumit Bharadwaj; Santosh K. Bhargava; Hongsheng Bi; Yufang Bi; Daniel Bia; Katia Biasch; Elysée Claude Bika Lele; Mukharram M. Bikbov; Bihungum Bista; Dusko J. Bjelica; Anne A. Bjerregaard; Peter Bjerregaard; Espen Bjertness; Marius B. Bjertness; Cecilia Björkelund; Katia V. Bloch; Anneke Blokstra; Moran Blychfeld Magnazu; Simona Bo; Martin Bobak; Lynne M. Boddy; Bernhard O. Boehm; Jolanda M. A. Boer; Jose G. Boggia; Elena Bogova; Carlos P. Boissonnet; Stig E. Bojesen; Marialaura Bonaccio; Vanina Bongard; Alice Bonilla-Vargas; Matthias Bopp; Herman Borghs; Pascal Bovet; Khadichamo Boymatova; Lien Braeckevelt; Lutgart Braeckman; Marjolijn C. E. Bragt; Imperia Brajkovich; Francesco Branca; Juergen Breckenkamp; João Breda; Hermann Brenner; Lizzy M. Brewster; Garry R. Brian; Yajaira Briceño; Lacramioara Brinduse; Miguel Brito; Sinead Brophy; Johannes Brug; Graziella Bruno; Anna Bugge; Frank Buntinx; Marta Buoncristiano; Genc Burazeri; Con Burns; Antonio Cabrera de León; Joseph Cacciottolo; Hui Cai; Roberta B. Caixeta; Tilema Cama; Christine Cameron; José Camolas; Günay Can; Ana Paula C. Cândido; Felicia Cañete; Mario V. Capanzana; Naděžda Čapková; Eduardo Capuano; Rocco Capuano; Vincenzo Capuano; Marloes Cardol; Viviane C. Cardoso; Axel C. Carlsson; Esteban Carmuega; Joana Carvalho; José A. Casajús; Felipe F. Casanueva; Maribel Casas; Ertugrul Celikcan; Laura Censi; Marvin Cervantes‐Loaiza; Juraci A. Cesar; Snehalatha Chamukuttan; Angelique Chan; Queenie Chan; Himanshu K. Chaturvedi; Nish Chaturvedi; Norsyamlina Che Abdul Rahim; Miao Li Chee; Chien-Jen Chen; Fangfang Chen; Huashuai Chen; Shuohua Chen; Zhengming Chen; Ching-Yu Cheng; Yiling J. Cheng; Bahman Cheraghian; Angela Chetrit; Ekaterina Chikova-Iscener; Mai J. M. Chinapaw; Anne Chinnock; Arnaud Chiolero; Shu-Ti Chiou; María-Dolores Chirlaque; Belong Cho; Kaare Christensen; Diego G. Christofaro; Jerzy Chudek; Renata Cifkova; Michelle Cilia; Eliza Cinteza; Massimo Cirillo; Frank Claessens; Janine Clarke; Els Clays; Emmanuel Cohen; Laura-María Compañ-Gabucio; Hans Concin; Susana C. Confortin; Cyrus Cooper; Tara C. Coppinger; Eva Corpeleijn; Lilia Yadira Cortés; Simona Costanzo; Dominique Cottel; Chris Cowell; Cora L. Craig; Amelia C. Crampin; Amanda J. Cross; Ana B. Crujeiras; Juan J. Cruz; Tamás Csányi; Semánová Csilla; Alexandra M. Cucu; Liufu Cui; Felipe V. Cureau; Sarah Cuschieri; Ewelina Czenczek-Lewandowska; Graziella D’Arrigo; Eleonora d’Orsi; Liliana Dacica; Jean Dallongeville; Albertino Damasceno; Camilla T. Damsgaard; Rachel Dankner; Thomas M. Dantoft; Parasmani Dasgupta; Saeed Dastgiri; Luc Dauchet; Kairat Davletov; Maria Alice Altenburg de Assis; Guy De Backer; Dirk De Bacquer; Amalia De Curtis; Patrícia de Fragas Hinnig; Giovanni de Gaetano; Stefaan De Henauw; Pilar De Miguel-Etayo; Paula Duarte de Oliveira; David De Ridder; Karin De Ridder; Susanne R. de Rooij; Delphine De Smedt; Mohan Deepa; Alexander D. Deev; Vincent DeGennaro; Hélène Delisle; Francis Delpeuch; Stefaan Demarest; Elaine Dennison; Katarzyna Dereń; Valérie Deschamps; Meghnath Dhimal; Augusto Di Castelnuovo; Juvenal Soares Dias-da-Costa; María Elena Díaz-Sánchez; Alejandro Diaz; Pedro Díaz Fernández; María Pilar Díez Ripollés; Zivka Dika; Shirin Djalalinia; Visnja Djordjic; Ha T. P. Do; Annette J. Dobson; Liria Dominguez; Maria Benedetta Donati; Chiara Donfrancesco; Guanghui Dong; Yanhui Dong; Silvana P. Donoso; Angela Döring; Maria Dorobantu; Ahmad Reza Dorosty; Kouamelan Doua; Nico Dragano; Wojciech Drygas; Jia Li Duan; Charmaine A. Duante; Priscilla Duboz; Vesselka L. Duleva; Virginija Dulskiene; Samuel C. Dumith; Anar Dushpanova; Azhar Dyussupova; Vilnis Dzerve; Elzbieta Dziankowska-Zaborszczyk; Guadalupe Echeverría; Ricky Eddie; Ebrahim Eftekhar; Eruke E. Egbagbe; Robert Eggertsen; Sareh Eghtesad; Gabriele Eiben; Ulf Ekelund; Mohammad El-Khateeb; Laila El Ammari; Jalila El Ati; Denise Eldemire-Shearer; Marie Eliasen; Paul Elliott; Ronit Endevelt; Reina Engle-Stone; Rajiv T. Erasmus; Raimund Erbel; Cihangir Erem; Gul Ergor; Louise Eriksen; Johan G. Eriksson; Jorge Escobedo-de la Peña; Saeid Eslami; Ali Esmaeili; Alun Evans; David Faeh; Ildar Fakhradiyev; Albina A. Fakhretdinova; Caroline H. Fall; Elnaz Faramarzi; Mojtaba Farjam; Victoria Farrugia Sant’Angelo; Mohammad Reza Fattahi; Asher Fawwad; Wafaie W. Fawzi; Edit Feigl; Francisco J. Felix-Redondo; Trevor S. Ferguson; Romulo A. Fernandes; Daniel Fernández-Bergés; Daniel Ferrante; Thomas Ferrao; Gerson Ferrari; Marika Ferrari; Marco M. Ferrario; Catterina Ferreccio; Haroldo S. Ferreira; Eldridge Ferrer; Jean Ferrieres; Thamara Hubler Figueiró; Anna Fijalkowska; Mauro Fisberg; Krista Fischer; Leng Huat Foo; Maria Forsner; Heba M. Fouad; Damian K. Francis; Maria do Carmo Franco; Zlatko Fras; Guillermo Frontera; Flavio D. Fuchs; Sandra C. Fuchs; Isti I. Fujiati; Yuki Fujita; Matsuda Fumihiko; Viktoriya Furdela; Takuro Furusawa; Zbigniew Gaciong; Mihai Gafencu; Manuel Galán Cuesta; Andrzej Galbarczyk; Henrike Galenkamp; Daniela Galeone; Myriam Galfo; Fabio Galvano; Jingli Gao; Pei Gao; Manoli Garcia-de-la-Hera; María José García Mérida; Marta García Solano; Dickman Gareta; Sarah P. Garnett; Jean-Michel Gaspoz; Magda Gasull; Adroaldo Cesar Araujo Gaya; Anelise Reis Gaya; Andrea Gazzinelli; Ulrike Gehring; Harald Geiger; Johanna M. Geleijnse; Ronnie George; Ebrahim Ghaderi; Ali Ghanbari; Erfan Ghasemi; Oana-Florentina Gheorghe-Fronea; Alessandro Gialluisi; Simona Giampaoli; Francesco Gianfagna; Christian Gieger; Tiffany K. Gill; Jonathan Giovannelli; Glen Gironella; Aleksander Giwercman; Konstantinos Gkiouras; Natalya Glushkova; Natalja Gluškova; Ramesh Godara; Justyna Godos; Sibel Gogen; Marcel Goldberg; David Goltzman; Georgina Gómez; Jesús Humberto Gómez Gómez; Luis F. Gomez; Santiago F. Gómez; Aleksandra Gomula; Bruna Gonçalves Cordeiro da Silva; Helen Gonçalves; Mauer Gonçalves; Ana D. González-Alvarez; David A. Gonzalez-Chica; Esther M. González-Gil; Marcela Gonzalez-Gross; Margot González-Leon; Juan P. González-Rivas; Clicerio González-Villalpando; María-Elena González-Villalpando; Angel R. Gonzalez; Frederic Gottrand; Antonio Pedro Graça; Sidsel Graff-Iversen; Dušan Grafnetter; Aneta Grajda; Maria G. Grammatikopoulou; Ronald D. Gregor; Maria João Gregório; Else Karin Grøholt; Anders Grøntved; Giuseppe Grosso; Gabriella Gruden; Dongfeng Gu; Viviana Guajardo; Emanuela Gualdi-Russo; Pilar Guallar-Castillón; Andrea Gualtieri; Elias F. Gudmundsson; Vilmundur Gudnason; Ramiro Guerrero; Idris Guessous; Andre L. Guimaraes; Martin C. Gulliford; Johanna Gunnlaugsdottir; Marc J. Gunter; Xiu-Hua Guo; Yin Guo; Prakash C. Gupta; Rajeev Gupta; Oye Gureje; Enrique Gutiérrez González; Laura Gutierrez; Felix Gutzwiller; Xinyi Gwee; Seongjun Ha; Farzad Hadaegh; Charalambos A. Hadjigeorgiou; Rosa Haghshenas; Hamid Hakimi; Jytte Halkjær; Ian R. Hambleton; Behrooz Hamzeh; Willem A. Hanekom; Dominique Hange; Abu A. M. Hanif; Sari Hantunen; Jie Hao; Carla Menêses Hardman; Rachakulla Hari Kumar; Tina Harmer Lassen; Javad Harooni; Seyed Mohammad Hashemi-Shahri; Maria Hassapidou; Jun Hata; Teresa Haugsgjerd; Alison J. Hayes; Jiang He; Yuan He; Yuna He; Regina Heidinger-Felső; Margit Heier; Tatjana Hejgaard; Marleen Elisabeth Hendriks; Rafael dos Santos Henrique; Ana Henriques; Leticia Hernandez Cadena; Sauli Herrala; Marianella Herrera-Cuenca; Victor M. Herrera; Isabelle Herter-Aeberli; Karl-Heinz Herzig; Ramin Heshmat; Allan G. Hill; Sai Yin Ho; Suzanne C. Ho; Michael Hobbs; Doroteia A. Höfelmann; Michelle Holdsworth; Reza Homayounfar; Clara Homs; Wilma M. Hopman; Andrea R. V. R. Horimoto; Claudia M. Hormiga; Bernardo L. Horta; Leila Houti; Christina Howitt; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; Yonghua Hu; José María Huerta; Ilpo Tapani Huhtaniemi; Laetitia Huiart; Constanta Huidumac Petrescu; Martijn Huisman; Abdullatif Husseini; Chinh Nguyen Huu; Inge Huybrechts; Nahla Hwalla; Jolanda Hyska; Licia Iacoviello; Ellina M. Iakupova; Jesús M. Ibarluzea; Mohsen M. Ibrahim; Norazizah Ibrahim Wong; M. Arfan Ikram; Carmen Iñiguez; Violeta Iotova; Vilma E. Irazola; Takafumi Ishida; Godsent C. Isiguzo; Muhammad Islam; Sheikh Mohammed Shariful Islam; Duygu Islek; Ivaila Y. Ivanova-Pandourska; Masanori Iwasaki; Tuija Jääskeläinen; Rod T. Jackson; Jeremy M. Jacobs; Michel Jadoul; Tazeen Jafar; Bakary Jallow; Kenneth James; Kazi M. Jamil; Konrad Jamrozik; Anna Jansson; Imre Janszky; Edward Janus; Juel Jarani; Marjo-Riitta Jarvelin; Grazyna Jasienska; Ana Jelaković; Bojan Jelaković; Garry Jennings; Chao Qiang Jiang; Ramon O. Jimenez; Karl-Heinz Jöckel; Michel Joffres; Jari J. Jokelainen; Jost B. Jonas; Jitendra Jonnagaddala; Torben Jørgensen; Pradeep Joshi; Josipa Josipović; Farahnaz Joukar; Jacek J. Jóźwiak; Debra S. Judge; Anne Juolevi; Gregor Jurak; Iulia Jurca Simina; Vesna Juresa; Rudolf Kaaks; Felix O. Kaducu; Anthony Kafatos; Mónika Kaj; Eero O. Kajantie; Natia Kakutia; Daniela Kállayová; Zhanna Kalmatayeva; Ofra Kalter-Leibovici; Yves Kameli; Freja B. Kampmann; Kodanda R. Kanala; Srinivasan Kannan; Efthymios Kapantais; Eva Karaglani; Argyro Karakosta; Line L. Kårhus; Khem B. Karki; Philippe B. Katchunga; Marzieh Katibeh; Joanne Katz; Peter T. Katzmarzyk; Jussi Kauhanen; Prabhdeep Kaur; Maryam Kavousi; Gyulli M. Kazakbaeva; François F. Kaze; Calvin Ke; Ulrich Keil; Lital Keinan Boker; Sirkka Keinänen-Kiukaanniemi; Roya Kelishadi; Cecily Kelleher; Han C. G. Kemper; Maryam Keramati; Alina Kerimkulova; Mathilde Kersting; Timothy Key; Yousef Saleh Khader; Arsalan Khaledifar; Davood Khalili; Kay-Tee Khaw; Bahareh Kheiri; Motahareh Kheradmand; Alireza Khosravi; Ilse M. S. L. Khouw; Ursula Kiechl-Kohlendorfer; Sophia J. Kiechl; Stefan Kiechl; Japhet Killewo; Hyeon Chang Kim; Jeongseon Kim; Jenny M. Kindblom; Andrew Kingston; Heidi Klakk; Magdalena Klimek; Jeannette Klimont; Jurate Klumbiene; Michael Knoflach; Bhawesh Koirala; Elin Kolle; Patrick Kolsteren; Jürgen König; Raija Korpelainen; Paul Korrovits; Magdalena Korzycka; Jelena Kos; Seppo Koskinen; Katsuyasu Kouda; Éva Kovács; Viktoria Anna Kovacs; Irina Kovalskys; Sudhir Kowlessur; Slawomir Koziel; Jana Kratenova; Wolfgang Kratzer; Vilma Kriaucioniene; Susi Kriemler; Peter Lund Kristensen; Helena Krizan; Maria F. Kroker-Lobos; Steinar Krokstad; Daan Kromhout; Herculina S. Kruger; Ruan Kruger; Łukasz Kryst; Ruzena Kubinova; Renata Kuciene; Urho M. Kujala; Enisa Kujundzic; Zbigniew Kulaga; Mukhtar Kulimbet; R. Krishna Kumar; Marie Kunešová; Pawel Kurjata; Yadlapalli S. Kusuma; Vladimir Kutsenko; Kari Kuulasmaa; Catherine Kyobutungi; Quang Ngoc La; Fatima Zahra Laamiri; Carl Lachat; Karl J. Lackner; Youcef Laid; Lachmie Lall; Tai Hing Lam; Maritza Landaeta Jimenez; Edwige Landais; Vera Lanska; Georg Lappas; Bagher Larijani; Simo Pone Larissa; Tint Swe Latt; Martino Laurenzi; Laura Lauria; Maria Lazo-Porras; Gwenaëlle Le Coroller; Khanh Le Nguyen Bao; Agnès Le Port; Tuyen D. Le; Jeannette Lee; Jeonghee Lee; Paul H. Lee; Nils Lehmann; Terho Lehtimäki; Daniel Lemogoum; Branimir Leskošek; Justyna Leszczak; Katja B. Leth-Møller; Gabriel M. Leung; Naomi S. Levitt; Yanping Li; Merike Liivak; Christa L. Lilly; Charlie Lim; Wei-Yen Lim; M. Fernanda Lima-Costa; Hsien-Ho Lin; Xu Lin; Yi-Ting Lin; Lars Lind; Vijaya Lingam; Birgit Linkohr; Allan Linneberg; Lauren Lissner; Mieczyslaw Litwin; Jing Liu; Lijuan Liu; Wei-Cheng Lo; Helle-Mai Loit; Khuong Quynh Long; Guadalupe Longo Abril; Luis Lopes; Marcus V. V. Lopes; Oscar Lopes; Esther Lopez-Garcia; Tania Lopez; Paulo A. Lotufo; José Eugenio Lozano; Janice L. Lukrafka; Dalia Luksiene; Annamari Lundqvist; Nuno Lunet; Charles Lunogelo; Michala Lustigová; Edyta Łuszczki; Jean-René M’Buyamba-Kabangu; Guansheng Ma; Xu Ma; George L. L. Machado-Coelho; Aristides M. Machado-Rodrigues; Enguerran Macia; Luisa M. Macieira; Ahmed A. Madar; Anja L. Madsen; Gladys E. Maestre; Stefania Maggi; Dianna J. Magliano; Sara Magnacca; Emmanuella Magriplis; Gowri Mahasampath; Bernard Maire; Marjeta Majer; Marcia Makdisse; Päivi Mäki; Fatemeh Malekzadeh; Reza Malekzadeh; Rahul Malhotra; Kodavanti Mallikharjuna Rao; Sofia K. Malyutina; Lynell V. Maniego; Yannis Manios; Masimango Imani Manix; Jim I. Mann; Fariborz Mansour-Ghanaei; Taru Manyanga; Enzo Manzato; Anie Marcil; Paula Margozzini; Joany Mariño; Anastasia Markaki; Oonagh Markey; Eliza Markidou Ioannidou; Pedro Marques-Vidal; Larissa Pruner Marques; Jaume Marrugat; Yves Martin-Prevel; Rosemarie Martin; Reynaldo Martorell; Eva Martos; Katharina Maruszczak; Stefano Marventano; Giovanna Masala; Luis P. Mascarenhas; Shariq R. Masoodi; Ellisiv B. Mathiesen; Prashant Mathur; Alicia Matijasevich; Piotr Matłosz; Tandi E. Matsha; Victor Matsudo; Christina Mavrogianni; Artur Mazur; Jean Claude N. Mbanya; Shelly R. McFarlane; Stephen T. McGarvey; Martin McKee; Stela McLachlan; Rachael M. McLean; Scott B. McLean; Margaret L. McNairy; Breige A. McNulty; Sounnia Mediene Benchekor; Jurate Medzioniene; Parinaz Mehdipour; Kirsten Mehlig; Amir Houshang Mehrparvar; Aline Meirhaeghe; Jørgen Meisfjord; Christa Meisinger; Jesus D. Melgarejo; Marina Melkumova; João Mello; Fabián Méndez; Carlos O. Mendivil; Ana Maria B. Menezes; Geetha R. Menon; Gert B. M. Mensink; Maria Teresa Menzano; Indrapal I. Meshram; Diane T. Meto; Jie Mi; Kim F. Michaelsen; Nathalie Michels; Kairit Mikkel; Karolina Miłkowska; Jody C. Miller; Olga Milushkina; Cláudia S. Minderico; G. K. Mini; Juan Francisco Miquel; J. Jaime Miranda; Mohammad Reza Mirjalili; Daphne Mirkopoulou; Erkin Mirrakhimov; Marjeta Mišigoj-Duraković; Antonio Mistretta; Veronica Mocanu; Pietro A. Modesti; Sahar Saeedi Moghaddam; Bahram Mohajer; Mostafa K. Mohamed; Shukri F. Mohamed; Kazem Mohammad; Mohammad Reza Mohammadi; Zahra Mohammadi; Noushin Mohammadifard; Reza Mohammadpourhodki; Viswanathan Mohan; Salim Mohanna; Muhammad Fadhli Mohd Yusoff; Iraj Mohebbi; Farnam Mohebi; Marie Moitry; Line T. Møllehave; Niels C. Møller; Dénes Molnár; Amirabbas Momenan; Charles K. Mondo; Roger A. Montenegro Mendoza; Eric Monterrubio-Flores; Kotsedi Daniel K. Monyeki; Jin Soo Moon; Mahmood Moosazadeh; Hermine T. Mopa; Farhad Moradpour; Leila B. Moreira; Alain Morejon; Luis A. Moreno; Francis Morey; Karen Morgan; Suzanne N. Morin; Erik Lykke Mortensen; George Moschonis; Alireza Moslem; Malgorzata Mossakowska; Aya Mostafa; Seyed-Ali Mostafavi; Anabela Mota-Pinto; Jorge Mota; Mohammad Esmaeel Motlagh; Jorge Motta; Marcos André Moura-dos-Santos; Yeva Movsesyan; Kelias P. Msyamboza; Thet Thet Mu; Magdalena Muc; Florian Muca; Boban Mugoša; Maria L. Muiesan; Martina Müller-Nurasyid; Thomas Münzel; Jaakko Mursu; Elaine M. Murtagh; Kamarul Imran Musa; Sanja Musić Milanović; Vera Musil; Geofrey Musinguzi; Muel Telo M. C. Muyer; Iraj Nabipour; Shohreh Naderimagham; Gabriele Nagel; Farid Najafi; Harunobu Nakamura; Hanna Nalecz; Jana Námešná; Ei Ei K. Nang; Vinay B. Nangia; Martin Nankap; Sameer Narake; Paola Nardone; Take Naseri; Matthias Nauck; William A. Neal; Azim Nejatizadeh; Chandini Nekkantti; Keiu Nelis; Ilona Nenko; Martin Neovius; Flavio Nervi; Tze Pin Ng; Chung T. Nguyen; Nguyen D. Nguyen; Quang Ngoc Nguyen; Michael Y. Ni; Rodica Nicolescu; Peng Nie; Ramfis E. Nieto-Martínez; Yury P. Nikitin; Guang Ning; Toshiharu Ninomiya; Nobuo Nishi; Sania Nishtar; Marianna Noale; Oscar A. Noboa; Helena Nogueira; Maria Nordendahl; Børge G. Nordestgaard; Davide Noto; Natalia Nowak-Szczepanska; Mohannad Al Nsour; Irfan Nuhoğlu; Baltazar Nunes; Eha Nurk; Fred Nuwaha; Moffat Nyirenda; Terence W. O’Neill; Dermot O’Reilly; Galina Obreja; Caleb Ochimana; Angélica M. Ochoa-Avilés; Eiji Oda; Augustine N. Odili; Kyungwon Oh; Kumiko Ohara; Claes Ohlsson; Ryutaro Ohtsuka; Örn Olafsson; Maria Teresa A. Olinto; Isabel O. Oliveira; Mohd Azahadi Omar; Saeed M. Omar; Altan Onat; Sok King Ong; N. Charlotte Onland-Moret; Lariane M. Ono; Pedro Ordunez; Rui Ornelas; Ana P. Ortiz; Pedro J. Ortiz; Merete Osler; Clive Osmond; Sergej M. Ostojic; Afshin Ostovar; Johanna A. Otero; Kim Overvad; Ellis Owusu-Dabo; Fred Michel Paccaud; Ioannis Pagkalos; Elena Pahomova; Karina Mary de Paiva; Andrzej Pająk; Alberto Palloni; Luigi Palmieri; Wen-Harn Pan; Songhomitra Panda-Jonas; Arvind Pandey; Francesco Panza; Mariela Paoli; Sousana K. Papadopoulou; Dimitrios Papandreou; Rossina G. Pareja; Soon-Woo Park; Suyeon Park; Winsome R. Parnell; Mahboubeh Parsaeian; Ionela M. Pascanu; Patrick Pasquet; Nikhil D. Patel; Marcos Pattussi; Halyna Pavlyshyn; Raimund Pechlaner; Ivan Pećin; Mangesh S. Pednekar; João M. Pedro; Nasheeta Peer; Sergio Viana Peixoto; Markku Peltonen; Alexandre C. Pereira; Marco A. Peres; Cynthia M. Pérez; Valentina Peterkova; Annette Peters; Astrid Petersmann; Janina Petkeviciene; Ausra Petrauskiene; Olga Petrovna Kovtun; Emanuela Pettenuzzo; Niloofar Peykari; Norbert Pfeiffer; Modou Cheyassin Phall; Son Thai Pham; Rafael N. Pichardo; Daniela Pierannunzio; Iris Pigeot; Hynek Pikhart; Aida Pilav; Lorenza Pilotto; Francesco Pistelli; Freda Pitakaka; Aleksandra Piwonska; Andreia N. Pizarro; Pedro Plans-Rubió; Alina G. Platonova; Bee Koon Poh; Hermann Pohlabeln; Nadija S. Polka; Raluca M. Pop; Stevo R. Popovic; Miquel Porta; Georg Posch; Anil Poudyal; Dimitrios Poulimeneas; Hamed Pouraram; Farhad Pourfarzi; Akram Pourshams; Hossein Poustchi; Rajendra Pradeepa; Alison J. Price; Jacqueline F. Price; Antonio Prista; Rui Providencia; Jardena J. Puder; Iveta Pudule; Maria Puiu; Margus Punab; Muhammed S. Qadir; Radwan F. Qasrawi; Mostafa Qorbani; Hedley K. Quintana; Pedro J. Quiroga-Padilla; Tran Quoc Bao; Stefan Rach; Ivana Radic; Ricardas Radisauskas; Salar Rahimikazerooni; Mahfuzar Rahman; Mahmudur Rahman; Olli Raitakari; Manu Raj; Tamerlan Rajabov; Sherali Rakhmatulloev; Ivo Rakovac; Sudha Ramachandra Rao; Ambady Ramachandran; Otim P. C. Ramadan; Virgílio V. Ramires; Jacqueline Ramke; Elisabete Ramos; Rafel Ramos; Lekhraj Rampal; Sanjay Rampal; Lalka S. Rangelova; Vayia Rarra; Ramon A. Rascon-Pacheco; Cassiano Ricardo Rech; Josep Redon; Paul Ferdinand M. Reganit; Valéria Regecová; Jane D. P. Renner; Judit A. Repasy; Cézane P. Reuter; Luis Revilla; Abbas Rezaianzadeh; Yeunsook Rho; Lourdes Ribas-Barba; Robespierre Ribeiro; Elio Riboli; Adrian Richter; Fernando Rigo; Attilio Rigotti; Natascia Rinaldo; Tobias F. Rinke de Wit; Ana I. Rito; Raphael M. Ritti-Dias; Juan A. Rivera; Reina G. Roa; Louise Robinson; Cynthia Robitaille; Romana Roccaldo; Daniela Rodrigues; Fernando Rodríguez-Artalejo; María del Cristo Rodriguez-Perez; Laura A. Rodríguez-Villamizar; Andrea Y. Rodríguez; Ulla Roggenbuck; Peter Rohloff; Fabian Rohner; Rosalba Rojas-Martinez; Nipa Rojroongwasinkul; Dora Romaguera; Elisabetta L. Romeo; Rafaela V. Rosario; Annika Rosengren; Ian Rouse; Vanessa Rouzier; Joel G. R. Roy; Maira H. Ruano; Adolfo Rubinstein; Frank J. Rühli; Jean-Bernard Ruidavets; Blanca Sandra Ruiz-Betancourt; Maria Ruiz-Castell; Emma Ruiz Moreno; Iuliia A. Rusakova; Kenisha Russell Jonsson; Paola Russo; Petra Rust; Marcin Rutkowski; Marge Saamel; Charumathi Sabanayagam; Hamideh Sabbaghi; Elena Sacchini; Harshpal S. Sachdev; Alireza Sadjadi; Ali Reza Safarpour; Sare Safi; Saeid Safiri; Mohammad Hossien Saghi; Olfa Saidi; Nader Saki; Sanja Šalaj; Benoit Salanave; Eduardo Salazar Martinez; Calogero Saleva; Diego Salmerón; Veikko Salomaa; Jukka T. Salonen; Massimo Salvetti; Margarita Samoutian; Jose Sánchez-Abanto; Inés Sánchez Rodríguez; Sandjaja; Susana Sans; Loreto Santa Marina; Ethel Santacruz; Diana A. Santos; Ina S. Santos; Lèlita C. Santos; Maria Paula Santos; Osvaldo Santos; Rute Santos; Tamara R. Santos; Jouko L. Saramies; Luis B. Sardinha; Nizal Sarrafzadegan; Thirunavukkarasu Sathish; Kai-Uwe Saum; Savvas Savva; Mathilde Savy; Norie Sawada; Mariana Sbaraini; Marcia Scazufca; Beatriz D. Schaan; Angelika Schaffrath Rosario; Herman Schargrodsky; Anja Schienkiewitz; Karin Schindler; Sabine Schipf; Carsten O. Schmidt; Ida Maria Schmidt; Andrea Schneider; Peter Schnohr; Ben Schöttker; Sara Schramm; Stine Schramm; Helmut Schröder; Constance Schultsz; Matthias B. Schulze; Aletta E. Schutte; Sylvain Sebert; Moslem Sedaghattalab; Rusidah Selamat; Vedrana Sember; Abhijit Sen; Idowu O. Senbanjo; Sadaf G. Sepanlou; Guillermo Sequera; Luis Serra-Majem; Jennifer Servais; Ľudmila Ševčíková; Svetlana Shalnova; Teresa Shamah-Levy; Seyed Morteza Shamshirgaran; Coimbatore Subramaniam Shanthirani; Maryam Sharafkhah; Sanjib K. Sharma; Jonathan E. Shaw; Amaneh Shayanrad; Ali Akbar Shayesteh; Lela Shengelia; Zumin Shi; Kenji Shibuya; Hana Shimizu-Furusawa; Tal Shimony; Rahman Shiri; Namuna Shrestha; Khairil Si-Ramlee; Alfonso Siani; Rosalynn Siantar; Abla M. Sibai; Labros S. Sidossis; Natalia Silitrari; Antonio M. Silva; Caroline Ramos de Moura Silva; Diego Augusto Santos Silva; Kelly S. Silva; Xueling Sim; Mary Simon; Judith Simons; Leon A. Simons; Agneta Sjöberg; Michael Sjöström; Natalia A. Skoblina; Gry Skodje; Tatyana Slazhnyova; Jolanta Slowikowska-Hilczer; Przemysław Slusarczyk; Liam Smeeth; Hung-Kwan So; Fernanda Cunha Soares; Grzegorz Sobek; Eugène Sobngwi; Morten Sodemann; Stefan Söderberg; Moesijanti Y. E. Soekatri; Agustinus Soemantri; Reecha Sofat; Vincenzo Solfrizzi; Mohammad Hossein Somi; Emily Sonestedt; Yi Song; Sajid Soofi; Thorkild I. A. Sørensen; Elin P. Sørgjerd; Charles Sossa Jérome; Victoria E. Soto-Rojas; Aïcha Soumaré; Alfonso Sousa-Poza; Slavica Sovic; Bente Sparboe-Nilsen; Karen Sparrenberger; Phoebe R. Spencer; Angela Spinelli; Igor Spiroski; Jan A. Staessen; Hanspeter Stamm; Kaspar Staub; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D. Stein; George S. Stergiou; Jochanan Stessman; Ranko Stevanović; Jutta Stieber; Doris Stöckl; Jakub Stokwiszewski; Ekaterina Stoyanova; Gareth Stratton; Karien Stronks; Maria Wany Strufaldi; Lela Sturua; Ramón Suárez-Medina; Machi Suka; Chien-An Sun; Liang Sun; Johan Sundström; Yn-Tz Sung; Jordi Sunyer; Paibul Suriyawongpaisal; Nabil William G. Sweis; Boyd A. Swinburn; Rody G. Sy; René Charles Sylva; Moyses Szklo; Lucjan Szponar; Lorraine Tabone; E. Shyong Tai; Konstantinos D. Tambalis; Mari-Liis Tammesoo; Abdonas Tamosiunas; Eng Joo Tan; Xun Tang; Maya Tanrygulyyeva; Frank Tanser; Yong Tao; Mohammed Rasoul Tarawneh; Jakob Tarp; Carolina B. Tarqui-Mamani; Radka Taxová Braunerová; Anne Taylor; Julie Taylor; Félicité Tchibindat; Saskia Te Velde; William R. Tebar; Grethe S. Tell; Tania Tello; Yih Chung Tham; K. R. Thankappan; Holger Theobald; Xenophon Theodoridis; Nihal Thomas; Barbara Thorand; Betina H. Thuesen; Ľubica Tichá; Erik J. Timmermans; Dwi H. Tjandrarini; Anne Tjonneland; Hanna K. Tolonen; Janne S. Tolstrup; Murat Topbas; Roman Topór-Mądry; Liv Elin Torheim; María José Tormo; Michael J. Tornaritis; Maties Torrent; Laura Torres-Collado; Stefania Toselli; Giota Touloumi; Pierre Traissac; Thi Tuyet-Hanh Tran; Mark S. Tremblay; Areti Triantafyllou; Dimitrios Trichopoulos; Antonia Trichopoulou; Oanh T. H. Trinh; Atul Trivedi; Yu-Hsiang Tsao; Lechaba Tshepo; Maria Tsigga; Panagiotis Tsintavis; Shoichiro Tsugane; John Tuitele; Azaliia M. Tuliakova; Marshall K. Tulloch-Reid; Fikru Tullu; Tomi-Pekka Tuomainen; Jaakko Tuomilehto; Maria L. Turley; Gilad Twig; Per Tynelius; Evangelia Tzala; Themistoklis Tzotzas; Christophe Tzourio; Peter Ueda; Eunice Ugel; Flora A. M. Ukoli; Hanno Ulmer; Belgin Unal; Zhamyila Usupova; Hannu M. T. Uusitalo; Nalan Uysal; Justina Vaitkeviciute; Gonzalo Valdivia; Susana Vale; Damaskini Valvi; Rob M. van Dam; Bert-Jan van den Born; Johan Van der Heyden; Yvonne T. van der Schouw; Koen Van Herck; Wendy Van Lippevelde; Hoang Van Minh; Natasja M. Van Schoor; Irene G. M. van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Anette Varbo; Gregorio Varela-Moreiras; Luz Nayibe Vargas; Patricia Varona-Pérez; Senthil K. Vasan; Daniel G. Vasques; Tomas Vega; Toomas Veidebaum; Gustavo Velasquez-Melendez; Biruta Velika; Maïté Verloigne; Giovanni Veronesi; W. M. Monique Verschuren; Cesar G. Victora; Giovanni Viegi; Lucie Viet; Frøydis N. Vik; Monica Vilar; Salvador Villalpando; Jesus Vioque; Jyrki K. Virtanen; Sophie Visvikis-Siest; Bharathi Viswanathan; Mihaela Vladulescu; Tiina Vlasoff; Dorja Vocanec; Peter Vollenweider; Henry Völzke; Ari Voutilainen; Martine Vrijheid; Tanja G. M. Vrijkotte; Alisha N. Wade; Thomas Waldhör; Janette Walton; Elvis O. A. Wambiya; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Rildo de Souza Wanderley Júnior; Ming-Dong Wang; Ningli Wang; Qian Wang; Xiangjun Wang; Ya Xing Wang; Ying-Wei Wang; S. Goya Wannamethee; Nicholas Wareham; Adelheid Weber; Karen Webster-Kerr; Niels Wedderkopp; Daniel Weghuber; Wenbin Wei; Aneta Weres; Bo Werner; Leo D. Westbury; Peter H. Whincup; Kremlin Wickramasinghe; Kurt Widhalm; Indah S. Widyahening; Andrzej Więcek; Philipp S. Wild; Rainford J. Wilks; Johann Willeit; Peter Willeit; Julianne Williams; Tom Wilsgaard; Rusek Wojciech; Bogdan Wojtyniak; Kathrin Wolf; Roy A. Wong-McClure; Andrew Wong; Emily B. Wong; Jyh Eiin Wong; Tien Yin Wong; Jean Woo; Mark Woodward; Frederick C. Wu; Hon-Yen Wu; Jianfeng Wu; Li Juan Wu; Shouling Wu; Justyna Wyszyńska; Haiquan Xu; Liang Xu; Nor Azwany Yaacob; Uruwan Yamborisut; Weili Yan; Ling Yang; Xiaoguang Yang; Yang Yang; Nazan Yardim; Tabara Yasuharu; Martha Yépez García; Panayiotis K. Yiallouros; Agneta Yngve; Moein Yoosefi; Akihiro Yoshihara; Qi Sheng You; San-Lin You; Novie O. Younger-Coleman; Yu-Ling Yu; Yunjiang Yu; Safiah Md Yusof; Ahmad Faudzi Yusoff; Luciana Zaccagni; Vassilis Zafiropulos; Ahmad A. Zainuddin; Seyed Rasoul Zakavi; Farhad Zamani; Sabina Zambon; Antonis Zampelas; Hana Zamrazilová; Maria Elisa Zapata; Abdul Hamid Zargar; Ko Ko Zaw; Ayman A. Zayed; Tomasz Zdrojewski; Magdalena Żegleń; Kristyna Zejglicova; Tajana Zeljkovic Vrkic; Yi Zeng; Luxia Zhang; Zhen-Yu Zhang; Dong Zhao; Ming-Hui Zhao; Wenhua Zhao; Yanitsa V. Zhecheva; Shiqi Zhen; Wei Zheng; Yingfeng Zheng; Bekbolat Zholdin; Maigeng Zhou; Dan Zhu; Marie Zins; Emanuel Zitt; Yanina Zocalo; Nada Zoghlami; Julio Zuñiga Cisneros; Monika Zuziak; Zulfiqar A. Bhutta; Robert E. Black; Majid Ezzati
    Nature 615 7954 874 - 883 2023年03月 [査読有り]
     
    Abstract Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
  • Katsuyasu Kouda; Yuki Fujita; Chikako Nakama; Kumiko Ohara; Takahiro Tachiki; Junko Tamaki; Akiko Yura; Jong-Seong Moon; Etsuko Kajita; Nami Imai; Kazuhiro Uenishi; Masayuki Iki
    Environmental health and preventive medicine 28 30 - 30 2023年 
    BACKGROUND: Central obesity as measured by waist-to-hip circumference ratio (WHR) has been reported to be associated with renal hemodynamics and function. However, the adipose component of WHR, which is a composite measure of fat mass and fat-free mass, is small, particularly in nonobese subjects. Trunk-to-peripheral fat ratio as measured using dual-energy absorptiometry (DXA) is a more precise method for evaluating central fat distribution than WHR. The present study investigated the cross-sectional association between DXA-measured trunk-to-peripheral fat ratio and estimated glomerular filtration rate (eGFR) in community-dwelling elderly Japanese men. METHODS: Participants were 575 men aged ≥65 years at the time of the baseline survey of the second Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort study. Trunk-to-appendicular fat ratio (TAR) was calculated as trunk fat divided by appendicular fat (sum of arm and leg fat), and trunk-to-leg fat ratio (TLR) as trunk fat divided by leg fat. RESULTS: eGFR values significantly decreased from the lowest to the highest quintile of TAR/TLR. After adjusting for potential confounding factors including whole-body fat, the highest quintile of both TAR and TLR showed statistically significant odds ratios for the risk of eGFR <60 ml/min/1.73 m2, relative to the lowest quintile. In addition, a significant decreasing trend was observed for eGFR values from the lowest to the highest quintile of TAR/TLR after adjusting for confounding factors including whole-body fat. CONCLUSION: Elderly men with a large trunk-to-peripheral fat ratio tended to have a lower eGFR. This association occurred independently of that between whole-body fat and eGFR.
  • L Vandenput; H Johansson; E V McCloskey; E Liu; K E Åkesson; F A Anderson; R Azagra; C L Bager; C Beaudart; H A Bischoff-Ferrari; E Biver; O Bruyère; J A Cauley; J R Center; R Chapurlat; C Christiansen; C Cooper; C J Crandall; S R Cummings; J A P da Silva; B Dawson-Hughes; A Diez-Perez; A B Dufour; J A Eisman; P J M Elders; S Ferrari; Y Fujita; S Fujiwara; C-C Glüer; I Goldshtein; D Goltzman; V Gudnason; J Hall; D Hans; M Hoff; R J Hollick; M Huisman; M Iki; S Ish-Shalom; G Jones; M K Karlsson; S Khosla; D P Kiel; W-P Koh; F Koromani; M A Kotowicz; H Kröger; T Kwok; O Lamy; A Langhammer; B Larijani; K Lippuner; D Mellström; T Merlijn; A Nordström; P Nordström; T W O'Neill; B Obermayer-Pietsch; C Ohlsson; E S Orwoll; J A Pasco; F Rivadeneira; B Schei; A-M Schott; E J Shiroma; K Siggeirsdottir; E M Simonsick; E Sornay-Rendu; R Sund; K M A Swart; P Szulc; J Tamaki; D J Torgerson; N M van Schoor; T P van Staa; J Vila; N J Wareham; N C Wright; N Yoshimura; M C Zillikens; M Zwart; N C Harvey; M Lorentzon; W D Leslie; J A Kanis
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 33 10 2103 - 2136 2022年10月 
    UNLABELLED: We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures. INTRODUCTION: The availability of the fracture risk assessment tool FRAX® has substantially enhanced the targeting of treatment to those at high risk of fracture with FRAX now incorporated into more than 100 clinical osteoporosis guidelines worldwide. The aim of this study is to determine whether the current algorithms can be further optimised with respect to current and novel risk factors. METHODS: A computerised literature search was performed in PubMed from inception until May 17, 2019, to identify eligible cohorts for updating the FRAX coefficients. Additionally, we searched the abstracts of conference proceedings of the American Society for Bone and Mineral Research, European Calcified Tissue Society and World Congress of Osteoporosis. Prospective cohort studies with data on baseline clinical risk factors and incident fractures were eligible. RESULTS: Of the 836 records retrieved, 53 were selected for full-text assessment after screening on title and abstract. Twelve cohorts were deemed eligible and of these, 4 novel cohorts were identified. These cohorts, together with 60 previously identified cohorts, will provide the resource for constructing an updated version of FRAX comprising 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures. For each known and candidate risk factor, multivariate hazard functions for hip fracture, major osteoporotic fracture and death will be tested using extended Poisson regression. Sex- and/or ethnicity-specific differences in the weights of the risk factors will be investigated. After meta-analyses of the cohort-specific beta coefficients for each risk factor, models comprising 10-year probability of hip and major osteoporotic fracture, with or without femoral neck bone mineral density, will be computed. CONCLUSIONS: These assembled cohorts and described models will provide the framework for an updated FRAX tool enabling enhanced assessment of fracture risk (PROSPERO (CRD42021227266)).
  • Katsuyasu Kouda; Yuki Fujita; Kumiko Ohara; Harunobu Nakamura; Munkhjargal Dorjravdan; Chikako Nakama; Toshimasa Nishiyama; Masayuki Iki
    Journal of physiological anthropology 41 1 21 - 21 2022年05月 
    BACKGROUND: In Japan, height and weight measurements, taken for all children at birth and 1.5- and 3-year health checks, are recorded in the Mother and Child Health (MCH) Handbook, as required by the law. The present population-based retrospective cohort study aimed to evaluate the diagnostic performance of height and weight records in the Handbook for predicting excessive adiposity in adolescents. METHODS: The source population consisted of 8th grade students (800 students aged 14 years) registered at two public junior high schools. Of these, we excluded students who were born at a gestational age < 37 weeks or > 42 weeks. The present analyses included 435 participants who provided complete information. Body mass index (BMI) was calculated using height and weight records. Body fat mass at 14 years of age was measured by dual-energy X-ray absorptiometry (DXA). Diagnostic performance of BMI calculated from the MCH Handbook records to discriminate between the presence and absence of excessive adiposity at 14 years of age was evaluated using receiver operating characteristic (ROC) curve analysis. The area under the ROC curve (AUC) was used to quantify the diagnostic accuracy of BMI. RESULTS: With regard to the prediction of excessive fat at 14 years of age, AUCs and 95% confidence intervals for BMI at 1.5 and 3 years of age were greater than 0.5. Meanwhile, the AUC of BMI at birth was not significantly greater than 0.5. CONCLUSION: The present study findings indicate that BMI values calculated using MCH Handbook data have potential ability to distinguish between the presence and absence of excessive fat at 14 years of age.
  • Kumiko Ohara; Shujiro Tani; Tomoki Mase; Katsumasa Momoi; Katsuyasu Kouda; Yuki Fujita; Harunobu Nakamura; Masayuki Iki
    Eating and weight disorders : EWD 27 3 1141 - 1151 2022年04月 
    PURPOSE: We investigated associations among attitude toward breakfast, appetite for breakfast, wake time, personality traits, self-esteem, and frequency of eating breakfast in university students and proposed a model of factors affecting the frequency of eating breakfast. METHODS: The participants, 555 Japanese university students (177 men, 378 women), completed a questionnaire about their height and weight, living with family, wake time, frequency of eating breakfast, appetite for breakfast, attitude toward breakfast, personality traits, and self-esteem. Appetite for breakfast was evaluated with a four-point Likert-type scale. Attitude toward breakfast was assessed with a 13-item questionnaire using a five-point Likert-type scale; responses to the items were summed, and divided by the number of items to produce a score. RESULTS: Multiple linear regression analysis showed that frequency of eating breakfast was positively associated with appetite for breakfast and attitude toward breakfast, and inversely associated with wake time. Wake time was inversely associated with attitude toward breakfast, and appetite for breakfast was positively associated with attitude toward breakfast. Structural equation modeling showed that the structured model based on the multiple regression analysis was a good fit for both men (chi-square value to the degrees of freedom [χ2/df] = 1.096, root mean square error of approximation [RMSEA] = 0.023) and women (χ2/df = 1.510, RMSEA = 0.037). CONCLUSIONS: These results suggest that wake time and appetite for breakfast are directly associated with frequency of eating breakfast. Attitude toward breakfast mediates the indirect association between frequency of eating breakfast and both wake time and appetite for breakfast. LEVEL OF EVIDENCE: V, cross-sectional descriptive study.
  • 中間 千香子; 甲田 勝康; 藤田 裕規; 森川 将行; 小原 久未子; 立木 隆広; 玉置 淳子; 由良 晶子; 文 鐘聲; 梶田 悦子; 伊木 雅之
    日本衛生学雑誌 77 Suppl. S181 - S181 (一社)日本衛生学会 2022年03月
  • Yuki Fujita; Masayuki Iki; Akiko Yura; Akihiro Harano; Katsuyasu Kouda; Junko Tamaki; Yuho Sato; Takahiro Tachiki; Etsuko Kajita; Rika Ishizuka; Jong-Seong Moon; Nozomi Okamoto; Norio Kurumatani
    Bone 116240 - 116240 2021年10月 
    BACKGROUND: Several studies have examined the association between physical performance and fracture in women, but few such studies have targeted elderly men. This study aimed to determine whether the combined results of several physical performance tests can predict the subsequent incidence of fractures in elderly men after adjusting for confounding factors. METHODS: Of the 2174 elderly men who participated in this study, 2012 completed the baseline study visit, including physical performance tests (walking speed, hand grip strength, and one-leg standing) and measurement of bone mineral density by dual-energy X-ray absorptiometry. Follow-up study visits were conducted five and ten years later, during which incident fractures were identified by detailed interviews. We excluded 140 men with diseases or who took medications known to affect bone metabolism at baseline, 185 with missing values for predictors and potential confounding factors, and one who did not participate in any of the follow-up study visits. The remaining 1686 men were analyzed. Each physical performance test was analyzed by quartiles. Poor performance was defined as belonging to the worst quartile of performance. The association between physical performance and fracture was assessed using Cox proportional hazards models. RESULTS: We identified 175 clinical fractures (osteoporotic fracture: 77, major osteoporotic fracture: 48) in 1686 men during a mean follow-up period of 8.4 years. After adjusting for potential confounding factors including bone mineral density, men who performed poorly on all three physical performance tests had a 3.7-fold higher risk of osteoporotic fracture and a 6.6-fold higher risk of major osteoporotic fracture than men who did not perform poorly on any of the tests. CONCLUSIONS: Japanese elderly men who performed poorly on all three physical performance tests had a significantly higher risk of incident osteoporotic fracture independently of bone mineral density. The combined results of several physical performance tests may be useful for predicting incident fractures in elderly men.
  • Lancet (London, England) 398 10304 957 - 980 2021年09月 
    BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. FINDINGS: The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. INTERPRETATION: Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. FUNDING: WHO.
  • 多面的身体能力評価は日本人高齢男性の骨粗鬆症性骨折発生を予測する 藤原京スタディ男性骨粗鬆症コホート研究
    藤田 裕規; 伊木 雅之; 由良 晶子; 原納 明博; 甲田 勝康; 玉置 淳子; 佐藤 裕保; 立木 隆広; 梶田 悦子; 石塚 理香; 文 鐘聲; 岡本 希; 車谷 典男
    日本骨粗鬆症学会雑誌 7 Suppl.1 236 - 236 (一社)日本骨粗鬆症学会 2021年09月
  • Yuki Fujita; Katsuyasu Kouda; Kumiko Ohara; Harunobu Nakamura; Chikako Nakama; Toshimasa Nishiyama; Masayuki Iki
    Journal of physiological anthropology 40 1 10 - 10 2021年08月 
    BACKGROUND: Rapid weight gain in early life is associated with adiposity later in life. However, there is limited information on the association between weight gain and body fat mass measured using precise methods. This study aimed to investigate whether weight gain is associated with body fat mass measured by dual-energy X-ray absorptiometry (DXA) in adolescents. METHODS: Participants of this retrospective cohort study were 423 adolescents born at full-term who were enrolled in the Japan Kids Body-composition Study. Anthropometric measurements related to pregnancy, delivery, and child health were obtained from the Japanese Maternal and Child Health Handbook. Fat mass in adolescents was measured with a DXA scanner. Weight gain was defined as the change in body weight from birth to age 1.5 years. Associations between birthweight and fat mass, and between weight gain and fat mass, were evaluated using multiple regression analysis. RESULTS: There was a significant positive association between weight gain from birth to age 1.5 years and fat mass in adolescents (boys: standardized regression coefficient (β) = 0.253, p < 0.01; girls: β = 0.246, p < 0.01), but not between birthweight standardized for gestational age and fat mass. CONCLUSION: Children with a greater change in weight from birth to age 1.5 years tended to have increased fat mass in adolescence. Weight gain in early life has a greater impact on fat mass in adolescents than birthweight.
  • Masayuki Iki; Akiko Yura; Yuki Fujita; Katsuyasu Kouda; Junko Tamaki; Takahiro Tachiki; Etsuko Kajita; Hirohisa Iwaki; Rika Ishizuka; Jong-Seong Moon; Nozomi Okamoto; Norio Kurumatani
    Bone 147 115912 - 115912 2021年06月 
    INTRODUCTION: Cross-sectional studies have shown that patients with type 2 diabetes mellitus (T2DM) have low circulating levels of osteocalcin (OC) and undercarboxylated OC (ucOC). This longitudinal study aimed to examine whether low OC or ucOC levels at baseline are associated with the risk of incident T2DM. METHODS: We examined 1700 community-dwelling Japanese men (≥65 years) after excluding those with history of diseases (other than T2DM) or medications that affect bone and glucose metabolism. T2DM was defined as fasting plasma glucose (FPG) ≥126 mg/dl or glycated hemoglobin A1c (HbA1c) ≥6.5%. Participants without prevalent T2DM at baseline were invited to follow-up surveys 5 and 10 years after baseline. RESULTS: Among the participants, 309 with prevalent T2DM showed significantly lower serum OC and ucOC levels at baseline than those without. After excluding these participants, 46 and 57 participants with incident T2DM were identified in the first and second follow-up surveys, respectively. These participants did not show significantly different OC and ucOC levels at baseline relative to those without T2DM, although their FPG and HbA1c levels at baseline were significantly higher compared to those without incident T2DM. Increase in glycemic indices preceded decrease in OC and ucOC levels. OC and ucOC levels at baseline were not significantly associated with the risk of incident T2DM identified in the follow-up surveys. CONCLUSIONS: OC and ucOC levels at baseline were not significantly associated with the risk of incident T2DM. Our results do not support the findings of animal studies that ucOC is a hormone regulating glucose metabolism.
  • Yuki Fujita; Junko Tamaki; Katsuyasu Kouda; Akiko Yura; Yuho Sato; Takahiro Tachiki; Masami Hamada; Etsuko Kajita; Kuniyasu Kamiya; Kazuki Kaji; Koji Tsuda; Kumiko Ohara; Jong-Seong Moon; Jun Kitagawa; Masayuki Iki
    Environmental health and preventive medicine 26 1 51 - 51 2021年04月 
    BACKGROUND: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study was launched to investigate risk factors for osteoporotic fractures, interactions of osteoporosis with other non-communicable chronic diseases, and effects of fracture on QOL and mortality. METHODS: FORMEN baseline study participants (in 2007 and 2008) included 2012 community-dwelling men (aged 65-93 years) in Nara prefecture, Japan. Clinical follow-up surveys were conducted 5 and 10 years after the baseline survey, and 1539 and 906 men completed them, respectively. Supplemental mail, telephone, and visit surveys were conducted with non-participants to obtain outcome information. Survival and fracture outcomes were determined for 2006 men, with 566 deaths identified and 1233 men remaining in the cohort at 10-year follow-up. COMMENTS: The baseline survey covered a wide range of bone health-related indices including bone mineral density, trabecular microarchitecture assessment, vertebral imaging for detecting vertebral fractures, and biochemical markers of bone turnover, as well as comprehensive geriatric assessment items. Follow-up surveys were conducted to obtain outcomes including osteoporotic fracture, cardiovascular diseases, initiation of long-term care, and mortality. A complete list of publications relating to the FORMEN study can be found at https://www.med.kindai.ac.jp/pubheal/FORMEN/Publications.html .
  • Katsuyasu Kouda; Yuki Fujita; Kumiko Ohara; Takahiro Tachiki; Junko Tamaki; Akiko Yura; Jong-Seong Moon; Etsuko Kajita; Kazuhiro Uenishi; Masayuki Iki
    Environmental health and preventive medicine 26 1 35 - 35 2021年03月 
    BACKGROUND: Body mass-independent parameters might be more appropriate for assessing cardiometabolic abnormalities than weight-dependent indices in Asians who have relatively high visceral adiposity but low body fat. Dual-energy X-ray absorptiometry (DXA)-measured trunk-to-peripheral fat ratio is one such body mass-independent index. However, there are no reports on relationships between DXA-measured regional fat ratio and cardiometabolic risk factors targeting elderly Asian men. METHODS: We analyzed cross-sectional data of 597 elderly men who participated in the baseline survey of the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study, a community-based single-center prospective cohort study conducted in Japan. Whole-body fat and regional fat were measured with a DXA scanner. Trunk-to-appendicular fat ratio (TAR) was calculated as trunk fat divided by appendicular fat (sum of arm and leg fat), and trunk-to-leg fat ratio (TLR) as trunk fat divided by leg fat. RESULTS: Both TAR and TLR in the group of men who used ≥ 1 medication for hypertension, dyslipidemia, or diabetes ("user group"; N = 347) were significantly larger than those who did not use such medication ("non-user group"; N = 250) (P < 0.05). After adjusting for potential confounding factors including whole-body fat, both TAR and TLR were significantly associated with low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting serum insulin, and the insulin resistance index in the non-user group and non-overweight men in the non-user group (N = 199). CONCLUSION: The trunk-to-peripheral fat ratio was associated with cardiometabolic risk factors independently of whole-body fat mass. Parameters of the fat ratio may be useful for assessing cardiometabolic risk factors, particularly in underweight to normal-weight populations.
  • eLife 10 2021年03月 
    From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
  • Katsuyasu Kouda; Masayuki Iki; Yuki Fujita; Harunobu Nakamura; Masami Hamada; Kazuhiro Uenishi; Mari Miyake; Toshimasa Nishiyama
    Environmental Health and Preventive Medicine 25 1 2020年12月 [査読有り]
     
    Abstract Background Limited evidence exists regarding the relationship between central-to-peripheral fat ratio measured by dual-energy X-ray absorptiometry (DXA) and subsequent cardiometabolic risk in both pediatric and adult populations. Methods The present cohort study investigated the relationship between DXA-measured body fat distribution and cardiometabolic parameters. The source population was 275 4th–6th graders (aged 9.6–12.6 years) in the northeast region of Japan (Shiokawa area in Kitakata). A 3-year follow-up was conducted to obtain complete information from 155 normal-weight children (87 boys and 68 girls). Normal-weight children were identified using sex- and age-specific international cut-offs for body mass index (BMI) based on adult BMI values of 25 kg/m2 and 18.5 kg/m2, respectively. Body fat distribution was assessed using the trunk-to-appendicular fat ratio (TAR) and trunk-to-leg fat ratio (TLR) measured by DXA. Results In boys, systolic blood pressure (SBP) at follow-up showed a significant relationship with TAR at baseline after adjusting for age, height, pubic hair appearance, SBP, and whole body fat at baseline (β = 0.24, P < 0.05), and SBP also showed a significant relationship with TLR after adjusting for confounding factors including whole body fat (β = 0.25, P < 0.05). In girls, there were no significant relationships between blood pressure and TAR/TLR. Conclusion Body fat distribution in normal-weight boys predicted subsequent blood pressure levels in adolescence. The relationship between fat distribution and blood pressure was independent of fat volume.
  • Lancet (London, England) 396 10261 1511 - 1524 2020年11月 
    BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5-19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. FINDINGS: We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9-10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes-gaining too little height, too much weight for their height compared with children in other countries, or both-occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. INTERPRETATION: The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks. FUNDING: Wellcome Trust, AstraZeneca Young Health Programme, EU.
  • Yuki Fujita; Katsuyasu Kouda; Kumiko Ohara; Harunobu Nakamura; Masayuki Iki
    Journal of bone and mineral metabolism 38 6 878 - 884 2020年11月 [査読有り]
     
    INTRODUCTION: A number of studies have reported that pre-pregnancy overweight status is associated with offspring obesity, yet only a few studies have examined pre-pregnancy underweight status as it associates with offspring health. The aim of the present study was to assess the effect of pre-pregnancy underweight status in a mother on health outcomes in her offspring. To this end, the primary outcome examined in the present study was underweight status in the offspring, with a secondary outcome of offspring low bone mass. MATERIALS AND METHODS: The present retrospective cohort study, conducted from 2008 to 2011, targeted a source population of all students registered as fifth-graders at three public elementary schools in Hamamatsu and Fukuroi cities. Maternal height and weight before and after pregnancy and offspring weight and height at birth were obtained from the Maternal and Child Health Handbook. Offspring weight and height at age 10 years were measured using standard procedures. Offspring total body less head (TBLH) bone mineral content (BMC) was determined with a dual-energy X-ray absorptiometry scanner. RESULTS: Pre-pregnancy underweight status was found to be associated with an increased risk of an underweight status in female offspring (OR = 2.88, 95% CI 1.06-7.81). Offspring TBLH BMC in the underweight mother group was significantly lower than that in the non-underweight mother group. CONCLUSIONS: We determined that pre-pregnancy underweight status was more likely to lead to an underweight status and low TBLH BMC in school-aged offspring.
  • 幼児における体格・体組成に影響を及ぼす生活習慣因子の検討
    間瀬 知紀; 小原 久未子; 甲田 勝康; 藤田 裕規; 桃井 克将; 中村 晴信
    日本公衆衛生学会総会抄録集 79回 363 - 363 日本公衆衛生学会 2020年10月
  • Masayuki Iki; Akiko Yura; Yuki Fujita; Katsuyasu Kouda; Takahiro Tachiki; Junko Tamaki; Yuho Sato; Jong-Seong Moon; Masami Hamada; Etsuko Kajita; Nozomi Okamoto; Norio Kurumatani
    Bone 139 115519 - 115519 2020年10月 [査読有り]
     
    PURPOSE: The association between serum concentrations of uric acid (UA), a potent endogenous antioxidant, and fracture risk has not yet been examined for morphometric vertebral fracture (VF). This study aimed to determine whether serum UA concentrations are associated with risks of clinical osteoporotic fracture (OPF) and morphometric VF after adjusting for confounding factors including UA-lowering medications (ULMs). MATERIALS AND METHODS: A total of 2012 Japanese men aged ≥65 years completed the baseline study, which included serum UA measurement and X-ray absorptiometry-based VF assessment. We conducted a follow-up study five years later to identify incident OPFs and VFs. OPF was identified through interviews. Incident VF was defined as a vertebra which showed reduction in any of its anterior, central, or posterior heights by ≥20% during follow-up, and satisfied grade one or higher fracture criteria in Genant's method on follow-up images. Bone mineral density (BMD) of the hip and spine was measured by dual-energy X-ray absorptiometry at baseline and follow-up. RESULTS: We identified 45 clinical OPFs from 2000 men and 39 VFs from 1530 men during a mean follow-up period of 4.3 years. Hip BMD was significantly higher in higher UA concentration groups after adjusting for age and body mass index. A significantly decreased multivariate-adjusted odds ratio (OR) of incident VF was observed for the highest quartile groups of serum UA concentrations compared with the lowest quartile group (OR: 0.17, 95% confidence interval: 0.05-0.62). This OR remained significant after further adjusting for ULM use. ULM users in the lowest quartile group of serum UA concentrations had a significantly higher incidence rate of VF compared to the other quartile groups. CONCLUSIONS: Higher serum UA concentrations were associated with a lower risk of morphometric VF independently of ULM in Japanese elderly men. Excessive reduction of serum UA concentrations by ULM might increase VF risk.
  • 地域在住高齢男性における貧血と脆弱性骨折との関連 藤原京スタディ男性骨粗鬆症コホート研究(FORMEN study)の5年追跡
    貫井 裕次; 玉置 淳子; 藤田 裕規; 甲田 勝康; 立木 隆広; 梶田 悦子; 濱田 昌実; 神谷 訓康; 岡本 希; 伊木 雅之
    日本骨粗鬆症学会雑誌 6 Suppl.1 214 - 214 (一社)日本骨粗鬆症学会 2020年09月
  • Kumiko Ohara; Harunobu Nakamura; Katsuyasu Kouda; Yuki Fujita; Katsumasa Momoi; Tomoki Mase; Chiemi Carroll; Masayuki Iki
    Appetite 151 104690 - 104690 2020年08月 [査読有り]
     
    This study aimed to evaluate the psychometric properties of the 20-item Japanese version of the Dutch Eating Behavior Questionnaire for Children (DEBQ-C). A population-based sample of 502 Japanese school children who were fifth- and sixth-graders in elementary schools and first- and second-graders in junior high schools was assessed. A sample was randomly split into two subsamples, one for exploratory factor analysis (EFA) and another for confirmatory factor analysis (CFA). Internal consistency estimates for subscales (restrained, emotional, and external) were evaluated using Cronbach's alpha. Measurement invariance was examined across each subgroup (genders: boys and girls, school categories: elementary school and junior high school, body mass index (BMI) categories: underweight, normal weight, and overweight) by using multi-group CFA. The Japanese version of the DEBQ-C demonstrates good results of item analysis. The three-factor structure of the original DEBQ-C was supported by both EFA and CFA. The reliability of each factor was also satisfied (restrained: α = 0.86, emotional: α = 0.90, external: α = 0.86). Results of multi-group confirmatory factor analysis supported its metric and scalar or partial scalar measurement invariance across all subgroups. In gender subgroup, girls scored higher on restrained eating. In school subgroup, junior high school children scored higher on emotional and external eating. In BMI subgroup, overweight children scored higher on restrained eating. These findings suggest that the Japanese version of the DEBQ-C is a psychometrically valid and reliable instrument for assessing eating behaviors across gender, school categories, and BMI categories in Japanese children.
  • Nature 582 7810 73 - 77 2020年06月 [査読有り]
     
    High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
  • Katsuyasu Kouda; Masayuki Iki; Yuki Fujita; Harunobu Nakamura; Kumiko Ohara; Takahiro Tachiki; Toshimasa Nishiyama
    Journal of Epidemiology 30 1 24 - 29 2020年01月 [査読有り]
  • Katsuyasu Kouda; Masayuki Iki; Yuki Fujita; Harunobu Nakamura; Kazuhiro Uenishi; Kumiko Ohara; Toshimasa Nishiyama
    Journal of nutritional science and vitaminology 66 2 158 - 167 2020年 [査読有り]
     
    Calcium intake during a growth spurt may influence bone mineral acquisition. However, no population-based cohort studies have examined the relationship between calcium intake and whole-body bone mineral acquisition in Japanese children. The present study investigated the relationship between calcium intake and whole-body bone mineral acquisition in community-dwelling children in a northeast region of Japan using dual-energy X-ray absorptiometry. The source population for the baseline survey comprised all school children in 4th through 6th grades (275 children; age range, 10-12 y) in the Shiokawa area of Kitakata City, Fukushima. We obtained complete information from 220 children (100 girls and 120 boys), and analyzed total body less head (TBLH) bone mineral content (BMC), TBLH areal bone mineral density (aBMD), and bone mineral apparent density (BMAD) as an estimate of volumetric bone density. The Food Frequency Questionnaire for the Prevention and Management of Osteoporosis was validated in a previous study and used to estimate dietary nutrient intake. At baseline, mean calcium intake was 641 mg/d in girls and 660 mg/d in boys. Calcium intake in boys showed a significant (p<0.05) relationship with TBLH BMC and TBLH aBMD at follow-up, and with changes in TBLH BMC, TBLH aBMD, and TB BMAD from baseline to follow-up. After adjusting for potential confounding factors including body weight, we found no significant relationships between calcium intake and bone mineral parameters. Further studies are needed to clarify whether calcium intake affects bone mineral acquisition during pubertal growth spurts in the Japanese population.
  • Takahiro Tachiki; Katsuyasu Kouda; Namiraa Dongmei; Junko Tamaki; Masayuki Iki; Jun Kitagawa; Naonobu Takahira; Yuho Sato; Etsuko Kajita; Yuki Fujita; Akiko Yura; Sadanobu Kagamimori
    Journal of bone and mineral metabolism 38 1 137 - 138 2020年01月 [査読有り]
  • Katsuyasu Kouda; Masayuki Iki; Kumiko Ohara; Harunobu Nakamura; Yuki Fujita; Toshimasa Nishiyama
    Journal of physiological anthropology 38 1 16 - 16 2019年12月 [査読有り]
     
    BACKGROUND: Epidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. Here, we investigated the association between serum levels of IGF-I and bone status during puberty. METHODS: We analyzed prospective 3-year follow-up data of 254 community-dwelling children who completed both baselines (at age 11.2 years) and follow-up (at age 14.2 years) surveys in Hamamatsu, Japan. Total body (TB) bone area and bone mineral parameters were assessed using dual-energy X-ray absorptiometry. RESULTS: During the 3-year follow-up period, there were significant (P < 0.05) increases in total body less head (TBLH) areal bone mineral density (aBMD), TBLH bone mineral content (BMC), and TB bone area, and a significant decrease in TB bone mineral apparent density (BMAD, volumetric bone mineral density, vBMD). IGF-I levels showed significant positive relationships with TBLH BMC and TBLH aBMD at both baseline and follow-up. TBLH aBMD in boys and TB BMAD in girls at follow-up showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. Similarly, changes in TBLH aBMD in boys and TB BMAD in girls during the 3-year follow-up period showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. CONCLUSIONS: These results suggest that pubertal children with high levels of serum IGF-I tended to have high bone mineral acquisition later on.
  • Masayuki Iki; Yuki Fujita; Katsuyasu Kouda; Akiko Yura; Takahiro Tachiki; Junko Tamaki; Yuho Sato; Jong-Seong Moon; Masami Hamada; Etsuko Kajita; Nozomi Okamoto; Norio Kurumatani
    Bone 127 250 - 259 2019年10月 [査読有り]
     
    PURPOSE: Many studies have reported that patients with a history of gastrectomy (gastrectomized patients) have lower areal bone mineral density (aBMD) and higher fracture risk than those without. However, population-based studies on this topic are scarce, and little is known regarding the bone metabolic status of gastrectomized patients in the long-term. This study aimed to clarify the association of gastrectomy with aBMD, bone metabolism markers, and fracture risk in community-dwelling elderly Japanese men. METHODS: A total of 1992 men aged ≥65 years completed baseline measurements including aBMD at the spine and hip, serum levels of intact parathyroid hormone (PTH), intact osteocalcin (OC), tartrate-resistant acid phosphatase isoenzyme 5b (TRACP5b), and undercarboxylated OC (ucOC), and an interview regarding past medical history including gastrectomy. Osteoporotic fractures (OPFs) that occurred during the 5-year follow-up period were determined through structured interviews. RESULTS: After excluding participants with type 1 diabetes mellitus and those with missing values, 1985 men, including 132 gastrectomized men, were analyzed. Gastrectomized men had significantly higher PTH, TRACP5b, and ucOC levels, and lower aBMD, than non-gastrectomized men. Gastrectomy was associated with a significantly higher risk of OPF after adjusting for confounding variables (hazard ratio (HR): 2.55, 95% confidence interval (CI): 1.17, 5.55), and the risk was no longer significant when further adjusted for PTH and aBMD. Even in this model, however, increase in OPF risk was significant in gastrectomized men who survived 20 years or more after the surgery (HR: 3.56, 95% CI: 1.33, 9.52). CONCLUSIONS: History of gastrectomy was associated with elevated bone resorption, decreased aBMD, and increased fracture risk in community-dwelling elderly Japanese men. This increase in fracture risk was more prominent long after gastrectomy.
  • シスタチンCに基づくeGFR低値は骨粗鬆症性骨折リスク上昇と関連したが、クレアチニンに基づくeGFRは関連しなかった 藤原京スタディ男性骨粗鬆症コホート研究
    伊木 雅之; 藤田 裕規; 甲田 勝康; 由良 晶子; 立木 隆広; 玉置 淳子; 佐藤 裕保; 梶田 悦子; 岡本 希; 車谷 典男
    日本骨粗鬆症学会雑誌 5 Suppl.1 414 - 414 (一社)日本骨粗鬆症学会 2019年09月
  • International journal of epidemiology 2019年07月 [査読有り]
     
    BACKGROUND: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. METHODS: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. RESULTS: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. CONCLUSIONS: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
  • Kumiko Ohara; Tomoki Mase; Katsuyasu Kouda; Chiemi Miyawaki; Katsumasa Momoi; Tomoko Fujitani; Yuki Fujita; Harunobu Nakamura
    Eating and weight disorders : EWD 24 3 521 - 531 2019年06月 [査読有り]
     
    PURPOSE: We investigated the association of anthropometric status, perceived stress, and personality traits with eating behavior in university students. METHODS: The participants, 1546 Japanese university students (964 males, 582 females), completed a questionnaire which asked for their current height and weight, ideal height and weight, eating behaviors, perceived stress, and personality traits. RESULTS: Restrained eating was higher in normal-weight participants compared with underweight participants in both males and females (p < 0.001, both males and females). Restrained eating in normal-weight males was significantly lower in normal-weight females (p < 0.001). In addition, normal-weight males reported less stress than normal-weight females (anxiety/uncertainty, p = 0.037; tiredness/physical responses, p < 0.001; autonomic symptoms, p < 0.001; depression/feeling, p < 0.001) and underweight males (tiredness/physical responses, p = 0.018; autonomic symptoms, p = 0.001). Moreover, among normal-weight males, neuroticism was significantly lower compared with normal-weight females (p < 0.001). In multiple regression analysis, male participants revealed positive association between restrained eating and body mass index (β = 0.199, p < 0.001) or body mass index difference (β = - 0.170, p = 0.001). In contrast, female revealed more significant associations between emotional and external eating and perceived stress or personality traits compared with males. CONCLUSIONS: These results indicate that associations between eating behavior and anthropometric status or psychological factors are different by each eating behavior, which is partly influenced by gender difference. LEVEL OF EVIDENCE: V, cross-sectional descriptive study.
  • Nature 569 7755 260 - 264 2019年05月 [査読有り]
     
    Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3-6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
  • Masayuki Iki; Yuki Fujita; Katsuyasu Kouda; Akiko Yura; Takahiro Tachiki; Junko Tamaki; Yuho Sato; Jong-Seong Moon; Masami Hamada; Etsuko Kajita; Nozomi Okamoto; Norio Kurumatani
    Bone 121 100 - 106 2019年04月 [査読有り]
     
    PURPOSE: Patients with type 2 diabetes mellitus have an increased fracture risk. However, population-based studies on the association between glycemic status and fracture risk are scarce, and none have targeted a Japanese population. In addition, patients in the lowest category of hemoglobin A1c (HbA1c) do not always show the lowest risk. This study aimed to clarify the association between glycemic status and fracture risk in community-dwelling elderly Japanese men. METHODS: A total of 1992 men aged ≥65 years completed baseline measurements including fasting plasma glucose (FPG), HbA1c, bone density, and an interview regarding past disease history. Osteoporotic fractures (OPFs) that occurred during the 5-year follow-up period were determined through interviews. An OPF at the spine, hip, proximal humerus, or distal radius was defined as a major OPF (MOF). RESULTS: After excluding participants who had a history of type 1 diabetes mellitus and thiazolidinedione therapy, 1951 men were analyzed. Men with hyperglycemia in the diabetic range had a significantly higher risk of OPF compared with those with normoglycemia, after adjusting for confounding factors including insulin therapy (hazard ratio (HR): 2.76, 95% confidence interval (CI): 1.17, 6.50 in FPG ≥ 126 mg/dl; HR: 2.49, 95% CI: 1.07, 5.77 in HbA1c ≥ 6.5%). An elevated risk of MOF was observed in participants in the prediabetic HbA1c category (HR: 2.15, 95% CI: 1.00, 4.62 in 5.7% ≤ HbA1c < 6.5%) in addition to those in the diabetic category. The intermediate glycemic status group showed intermediate risk, suggesting that the association was linear. CONCLUSIONS: Hyperglycemia was associated linearly with elevated fracture risk in community-dwelling elderly men. MOF risk may be elevated in Japanese elderly men with prediabetic glycemic status.
  • Yuki Fujita; Katsuyasu Kouda; Kumiko Ohara; Harunobu Nakamura; Masayuki Iki
    Medicine 98 12 e14934 - e14934 2019年03月 [査読有り]
  • Myadagmaa Jaalkhorol; Yuki Fujita; Katsuyasu Kouda; Junko Tamaki; Misa Komatsu; Namiraa DongMei; Yuho Sato; Takahiro Tachiki; Akiko Yura; Etsuko Kajita; Sadanobu Kagamimori; Masayuki Iki
    Maturitas 119 39 - 45 2019年01月 [査読有り]
  • Takahiro Tachiki; Katsuyasu Kouda; Namiraa Dongmei; Junko Tamaki; Masayuki Iki; Jun Kitagawa; Naonobu Takahira; Yuho Sato; Etsuko Kajita; Yuki Fujita; Akiko Yura; Sadanobu Kagamimori
    Journal of bone and mineral metabolism 37 1 53 - 59 2019年01月 [査読有り]
     
    There are conflicting reports on whether muscle strength is associated with bone mineral density (BMD) independently of muscle mass. Here, we examined the association between muscle strength and BMD in a representative population of Japanese women. Cross-sectional data from 680 postmenopausal women, who were participants in the 15th-year follow-up survey of the Japanese Population-based Osteoporosis cohort study, were analyzed. Areal BMD (aBMD) at the femoral neck and lumbar spine, whole-body bone mineral density, and appendicular skeletal muscle mass (ASM, kg) were measured by dual-energy X-ray absorptiometry. The ASM index (ASMI, kg/m2) was calculated as ASM divided by height squared (m2). Grip strength (kg) was measured as an indicator of muscle strength. Grip strength showed significantly (P < 0.05) positive relationships with aBMDs at several skeletal sites after adjusting for ASMI and age (standardized partial regression coefficient (β) = 0.102 at femoral neck, β = 0.126 at lumbar spine). Adjusted means of aBMD at the femoral neck and lumbar spine showed significant increasing trends from the lowest to highest tertile of grip strength. Our findings indicate that muscle strength is associated with aBMD at several sites independently of muscle mass in Japanese postmenopausal women. Thus, postmenopausal women with strong muscle strength tend to have a healthy bone status regardless of muscle size.
  • Yuki Fujita; Katsuyasu Kouda; Harunobu Nakamura; Masayuki Iki
    Journal of Epidemiology 28 12 498 - 502 2018年12月 [査読有り]
  • Bin Zhou; James Bentham; Mariachiara Di Cesare; Honor Bixby; Goodarz Danaei; Kaveh Hajifathalian; Cristina Taddei; Rodrigo M Carrillo-Larco; Shirin Djalalinia; Shahab Khatibzadeh; Charles Lugero; Niloofar Peykari; Wan Zhu Zhang; James Bennett; Ver Bilano; Gretchen A Stevens; Melanie J Cowan; Leanne M Riley; Zhengming Chen; Ian R Hambleton; Rod T Jackson; Andre Pascal Kengne; Young-Ho Khang; Avula Laxmaiah; Jing Liu; Reza Malekzadeh; Hannelore K Neuhauser; Maroje Sorić; Gregor Starc; Johan Sundström; Mark Woodward; Majid Ezzati; Leandra Abarca-Gómez; Ziad A Abdeen; Niveen M Abu-Rmeileh; Benjamin Acosta-Cazares; Robert J Adams; Wichai Aekplakorn; Kaosar Afsana; Carlos A Aguilar-Salinas; Charles Agyemang; Noor Ani Ahmad; Alireza Ahmadvand; Wolfgang Ahrens; Kamel Ajlouni; Nazgul Akhtaeva; Rajaa Al-Raddadi; Mohamed M Ali; Osman Ali; Ala'a Alkerwi; Eman Aly; Deepak N Amarapurkar; Philippe Amouyel; Antoinette Amuzu; Lars Bo Andersen; Sigmund A Anderssen; Lars H Ängquist; Ranjit Mohan Anjana; Daniel Ansong; Hajer Aounallah-Skhiri; Joana Araújo; Inger Ariansen; Tahir Aris; Nimmathota Arlappa; Dominique Arveiler; Krishna K Aryal; Thor Aspelund; Felix K Assah; Maria Cecília F Assunção; Mária Avdicová; Ana Azevedo; Fereidoun Azizi; Bontha V Babu; Suhad Bahijri; Nagalla Balakrishna; Mohamed Bamoshmoosh; Maciej Banach; Piotr Bandosz; José R Banegas; Carlo M Barbagallo; Alberto Barceló; Amina Barkat; Aluisio J D Barros; Mauro V Barros; Iqbal Bata; Anwar M Batieha; Assembekov Batyrbek; Louise A Baur; Robert Beaglehole; Habiba Ben Romdhane; Mikhail Benet; Lowell S Benson; Antonio Bernabe-Ortiz; Gailute Bernotiene; Heloisa Bettiol; Aroor Bhagyalaxmi; Sumit Bharadwaj; Santosh K Bhargava; Yufang Bi; Mukharram Bikbov; Bihungum Bista; Peter Bjerregaard; Espen Bjertness; Marius B Bjertness; Cecilia Björkelund; Anneke Blokstra; Simona Bo; Martin Bobak; Heiner Boeing; Jose G Boggia; Carlos P Boissonnet; Vanina Bongard; Rossana Borchini; Pascal Bovet; Lutgart Braeckman; Imperia Brajkovich; Francesco Branca; Juergen Breckenkamp; Hermann Brenner; Lizzy M Brewster; Graziella Bruno; H B(as) Bueno-de-Mesquita; Anna Bugge; Con Burns; Michael Bursztyn; Antonio Cabrera de León; Joseph Cacciottolo; Hui Cai; Christine Cameron; Günay Can; Ana Paula C Cândido; Vincenzo Capuano; Viviane C Cardoso; Axel C Carlsson; Maria J Carvalho; Felipe F Casanueva; Juan-Pablo Casas; Carmelo A Caserta; Snehalatha Chamukuttan; Angelique W Chan; Queenie Chan; Himanshu K Chaturvedi; Nishi Chaturvedi; Chien-Jen Chen; Fangfang Chen; Huashuai Chen; Shuohua Chen; Zhengming Chen; Ching-Yu Cheng; Imane Cherkaoui Dekkaki; Angela Chetrit; Arnaud Chiolero; Shu-Ti Chiou; Adela Chirita-Emandi; María-Dolores Chirlaque; Belong Cho; Yumi Cho; Diego G Christofaro; Jerzy Chudek; Renata Cifkova; Eliza Cinteza; Frank Claessens; Els Clays; Hans Concin; Cyrus Cooper; Rachel Cooper; Tara C Coppinger; Simona Costanzo; Dominique Cottel; Chris Cowell; Cora L Craig; Ana B Crujeiras; Juan J Cruz; Graziella D'Arrigo; Eleonora d'Orsi; Jean Dallongeville; Albertino Damasceno; Goodarz Danaei; Rachel Dankner; Thomas M Dantoft; Luc Dauchet; Kairat Davletov; Guy De Backer; Dirk De Bacquer; Giovanni de Gaetano; Stefaan De Henauw; Paula Duarte de Oliveira; Delphine De Smedt; Mohan Deepa; Abbas Dehghan; Hélène Delisle; Valérie Deschamps; Klodian Dhana; Augusto F Di Castelnuovo; Juvenal Soares Dias-da-Costa; Alejandro Diaz; Ty T Dickerson; Shirin Djalalinia; Ha T P Do; Chiara Donfrancesco; Silvana P Donoso; Angela Döring; Maria Dorobantu; Kouamelan Doua; Wojciech Drygas; Virginija Dulskiene; Aleksandar Džakula; Vilnis Dzerve; Elzbieta Dziankowska-Zaborszczyk; Robert Eggertsen; Ulf Ekelund; Jalila El Ati; Paul Elliott; Roberto Elosua; Rajiv T Erasmus; Cihangir Erem; Louise Eriksen; Johan G Eriksson; Jorge Escobedo-de la Peña; Alun Evans; David Faeh; Caroline H Fall; Farshad Farzadfar; Francisco J Felix-Redondo; Trevor S Ferguson; Romulo A Fernandes; Daniel Fernández-Bergés; Daniel Ferrante; Marika Ferrari; Catterina Ferreccio; Jean Ferrieres; Joseph D Finn; Krista Fischer; Bernhard Föger; Leng Huat Foo; Ann-Sofie Forslund; Maria Forsner; Heba M Fouad; Damian K Francis; Maria do Carmo Franco; Oscar H Franco; Guillermo Frontera; Flavio D Fuchs; Sandra C Fuchs; Yuki Fujita; Takuro Furusawa; Zbigniew Gaciong; Fabio Galvano; Manoli Garcia-de-la-Hera; Dickman Gareta; Sarah P Garnett; Jean-Michel Gaspoz; Magda Gasull; Louise Gates; Johanna M Geleijnse; Anoosheh Ghasemian; Anup Ghimire; Simona Giampaoli; Francesco Gianfagna; Tiffany K Gill; Jonathan Giovannelli; Rebecca A Goldsmith; Helen Gonçalves; Marcela Gonzalez-Gross; Juan P González-Rivas; Mariano Bonet Gorbea; Frederic Gottrand; Sidsel Graff-Iversen; Dušan Grafnetter; Aneta Grajda; Maria G Grammatikopoulou; Ronald D Gregor; Tomasz Grodzicki; Anders Grøntved; Giuseppe Grosso; Gabriella Gruden; Vera Grujic; Dongfeng Gu; Ong Peng Guan; Elias F Gudmundsson; Vilmundur Gudnason; Ramiro Guerrero; Idris Guessous; Andre L Guimaraes; Martin C Gulliford; Johanna Gunnlaugsdottir; Marc Gunter; Prakash C Gupta; Rajeev Gupta; Oye Gureje; Beata Gurzkowska; Laura Gutierrez; Felix Gutzwiller; Farzad Hadaegh; Jytte Halkjær; Ian R Hambleton; Rebecca Hardy; Rachakulla Hari Kumar; Jun Hata; Alison J Hayes; Jiang He; Yuna He; Marleen Elisabeth; Ana Henriques; Leticia Hernandez Cadena; Sauli Herrala; Ramin Heshmat; Ilpo Tapani Hihtaniemi; Sai Yin Ho; Suzanne C Ho; Michael Hobbs; Albert Hofman; Gonul Horasan Dinc; Andrea R V R Horimoto; Claudia M Hormiga; Bernardo L Horta; Leila Houti; Christina Howitt; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; Yonghua Hu; José María Huerta; Martijn Huisman; Abdullatif S Husseini; Inge Huybrechts; Nahla Hwalla; Licia Iacoviello; Anna G Iannone; Mohsen M Ibrahim; Norazizah Ibrahim Wong; Nayu Ikeda; M Arfan Ikram; Vilma E Irazola; Muhammad Islam; Aziz al-Safi Ismail; Vanja Ivkovic; Masanori Iwasaki; Rod T Jackson; Jeremy M Jacobs; Hashem Jaddou; Tazeen Jafar; Konrad Jamrozik; Imre Janszky; Grazyna Jasienska; Ana Jelaković; Bojan Jelaković; Garry Jennings; Seung-lyeal Jeong; Chao Qiang Jiang; Michel Joffres; Mattias Johansson; Jari J Jokelainen; Jost B Jonas; Torben Jørgensen; Pradeep Joshi; Jacek Jóźwiak; Anne Juolevi; Gregor Jurak; Vesna Jureša; Rudolf Kaaks; Anthony Kafatos; Eero O Kajantie; Ofra Kalter-Leibovici; Nor Azmi Kamaruddin; Khem B Karki; Amir Kasaeian; Joanne Katz; Jussi Kauhanen; Prabhdeep Kaur; Maryam Kavousi; Gyulli Kazakbaeva; Ulrich Keil; Lital Keinan Boker; Sirkka Keinänen-Kiukaanniemi; Roya Kelishadi; Han C G Kemper; Andre P Kengne; Alina Kerimkulova; Mathilde Kersting; Timothy Key; Yousef Saleh Khader; Davood Khalili; Young-Ho Khang; Mohammad Khateeb; Kay-Tee Khaw; Ursula Kiechl-Kohlendorfer; Stefan Kiechl; Japhet Killewo; Jeongseon Kim; Yeon-Yong Kim; Jurate Klumbiene; Michael Knoflach; Elin Kolle; Patrick Kolsteren; Paul Korrovits; Seppo Koskinen; Katsuyasu Kouda; Sudhir Kowlessur; Slawomir Koziel; Susi Kriemler; Peter Lund Kristensen; Steinar Krokstad; Daan Kromhout; Herculina S Kruger; Ruzena Kubinova; Renata Kuciene; Diana Kuh; Urho M Kujala; Zbigniew Kulaga; R Krishna Kumar; Pawel Kurjata; Yadlapalli S Kusuma; Kari Kuulasmaa; Catherine Kyobutungi; Tiina Laatikainen; Carl Lachat; Tai Hing Lam; Orlando Landrove; Vera Lanska; Georg Lappas; Bagher Larijani; Lars E Laugsand; Avula Laxmaiah; Khanh Le Nguyen Bao; Tuyen D Le; Catherine Leclercq; Jeannette Lee; Jeonghee Lee; Terho Lehtimäki; Luz M León-Muñoz; Naomi S Levitt; Yanping Li; Christa L Lilly; Wei-Yen Lim; M Fernanda Lima-Costa; Hsien-Ho Lin; Xu Lin; Lars Lind; Allan Linneberg; Lauren Lissner; Mieczyslaw Litwin; Jing Liu; Roberto Lorbeer; Paulo A Lotufo; José Eugenio Lozano; Dalia Luksiene; Annamari Lundqvist; Nuno Lunet; Per Lytsy; Guansheng Ma; Jun Ma; George L L Machado-Coelho; Suka Machi; Stefania Maggi; Dianna J Magliano; Emmanuella Magriplis; Marjeta Majer; Marcia Makdisse; Reza Malekzadeh; Rahul Malhotra; Kodavanti Mallikharjuna Rao; Sofia Malyutina; Yannis Manios; Jim I Mann; Enzo Manzato; Paula Margozzini; Pedro Marques-Vidal; Larissa Pruner Marques; Jaume Marrugat; Reynaldo Martorell; Ellisiv B Mathiesen; Alicia Matijasevich; Tandi E Matsha; Jean Claude N Mbanya; Anselmo J Mc Donald Posso; Shelly R McFarlane; Stephen T McGarvey; Stela McLachlan; Rachael M McLean; Scott B McLean; Breige A McNulty; Sounnia Mediene-Benchekor; Jurate Medzioniene; Aline Meirhaeghe; Christa Meisinger; Ana Maria B Menezes; Geetha R Menon; Indrapal I Meshram; Andres Metspalu; Haakon E Meyer; Jie Mi; Kairit Mikkel; Jody C Miller; Cláudia S Minderico; Juan Francisco; J Jaime Miranda; Erkin Mirrakhimov; Marjeta Mišigoj-Durakovic; Pietro A Modesti; Mostafa K Mohamed; Kazem Mohammad; Noushin Mohammadifard; Viswanathan Mohan; Salim Mohanna; Muhammad Fadhli Mohd Yusoff; Line T Møllehave; Niels C Møller; Dénes Molnár; Amirabbas Momenan; Charles K Mondo; Kotsedi Daniel K Monyeki; Jin Soo Moon; Leila B Moreira; Alain Morejon; Luis A Moreno; Karen Morgan; George Moschonis; Malgorzata Mossakowska; Aya Mostafa; Jorge Mota; Mohammad Esmaeel Motlagh; Jorge Motta; Kelias P Msyamboza; Thet Thet Mu; Maria L Muiesan; Martina Müller-Nurasyid; Neil Murphy; Jaakko Mursu; Vera Musil; Iraj Nabipour; Gabriele Nagel; Balkish M Naidu; Harunobu Nakamura; Jana Námešná; Ei Ei K Nang; Vinay B Nangia; Sameer Narake; Matthias Nauck; Eva Maria Navarrete-Muñoz; Ndeye Coumba Ndiaye; William A Neal; Ilona Nenko; Martin Neovius; Flavio Nervi; Hannelore K Neuhauser; Chung T Nguyen; Nguyen D Nguyen; Quang Ngoc Nguyen; Quang V Nguyen; Ramfis E Nieto-Martínez; Teemu J Niiranen; Guang Ning; Toshiharu Ninomiya; Sania Nishtar; Marianna Noale; Oscar A Noboa; Ahmad Ali Noorbala; Teresa Norat; Davide Noto; Mohannad Al Nsour; Dermot O'Reilly; Eiji Oda; Glenn Oehlers; Kyungwon Oh; Kumiko Ohara; Maria Teresa A Olinto; Isabel O Oliveira; Mohd Azahadi Omar; Altan Onat; Sok King Ong; Lariane M Ono; Pedro Ordunez; Rui Ornelas; Clive Osmond; Sergej M Ostojic; Afshin Ostovar; Johanna A Otero; Kim Overvad; Ellis Owusu-Dabo; Fred Michel Paccaud; Cristina Padez; Elena Pahomova; Andrzej Pajak; Domenico Palli; Luigi Palmieri; Wen-Harn Pan; Songhomitra Panda-Jonas; Francesco Panza; Dimitrios Papandreou; Soon-Woo Park; Winsome R Parnell; Mahboubeh Parsaeian; Nikhil D Patel; Ivan Pecin; Mangesh S Pednekar; Nasheeta Peer; Petra H Peeters; Sergio Viana Peixoto; Markku Peltonen; Alexandre C Pereira; Annette Peters; Astrid Petersmann; Janina Petkeviciene; Niloofar Peykari; Son Thai Pham; Iris Pigeot; Hynek Pikhart; Aida Pilav; Lorenza Pilotto; Freda Pitakaka; Aleksandra Piwonska; Pedro Plans-Rubió; Ozren Polašek; Miquel Porta; Marileen L P Portegies; Akram Pourshams; Hossein Poustchi; Rajendra Pradeepa; Mathur Prashant; Jacqueline F Price; Jardena J Puder; Maria Puiu; Margus Punab; Radwan F Qasrawi; Mostafa Qorbani; Tran Quoc Bao; Ivana Radic; Ricardas Radisauskas; Mahfuzar Rahman; Olli Raitakari; Manu Raj; Sudha Ramachandra Rao; Ambady Ramachandran; Elisabete Ramos; Lekhraj Rampal; Sanjay Rampal; Daniel A Rangel Reina; Josep Redon; Paul Ferdinand M Reganit; Robespierre Ribeiro; Elio Riboli; Fernando Rigo; Tobias F Rinke de Wit; Raphael M Ritti-Dias; Sian M Robinson; Cynthia Robitaille; Fernando Rodríguez-Artalejo; María del Cristo Rodriguez-Perez; Laura A Rodríguez-Villamizar; Rosalba Rojas-Martinez; Dora Romaguera; Kimmo Ronkainen; Annika Rosengren; Joel G R Roy; Adolfo Rubinstein; Blanca Sandra Ruiz-Betancourt; Marcin Rutkowski; Charumathi Sabanayagam; Harshpal S Sachdev; Olfa Saidi; Sibel Sakarya; Benoit Salanave; Eduardo Salazar Martinez; Diego Salmerón; Veikko Salomaa; Jukka T Salonen; Massimo Salvetti; Jose Sánchez-Abanto; Susana Sans; Diana A Santos; Ina S Santos; Renata Nunes dos Santos; Rute Santos; Jouko L Saramies; Luis B Sardinha; Giselle Sarganas; Nizal Sarrafzadegan; Kai-Uwe Saum; Savvas Savva; Marcia Scazufca; Herman Schargrodsky; Sabine Schipf; Carsten O Schmidt; Ben Schöttker; Constance Schultsz; Aletta E Schutte; Aye Aye Sein; Abhijit Sen; Idowu O Senbanjo; Sadaf G Sepanlou; Sanjib K Sharma; Jonathan E Shaw; Kenji Shibuya; Dong Wook Shin; Youchan Shin; Khairil Si-Ramlee; Rosalynn Siantar; Abla M Sibai; Diego Augusto Santos Silva; Mary Simon; Judith Simons; Leon A Simons; Michael Sjöström; Sine Skovbjerg; Jolanta Slowikowska-Hilczer; Przemyslaw Slusarczyk; Liam Smeeth; Margaret C Smith; Marieke B Snijder; Hung-Kwan So; Eugène Sobngwi; Stefan Söderberg; Vincenzo Solfrizzi; Emily Sonestedt; Yi Song; Thorkild I A Sørensen; Maroje Soric; Charles Sossa Jérome; Aicha Soumare; Jan A Staessen; Gregor Starc; Maria G Stathopoulou; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D Stein; George S Stergiou; Jochanan Stessman; Jutta Stieber; Doris Stöckl; Tanja Stocks; Jakub Stokwiszewski; Karien Stronks; Maria Wany Strufaldi; Chien-An Sun; Johan Sundström; Yn-Tz Sung; Paibul Suriyawongpaisal; Rody G Sy; E Shyong Tai; Mari-Liis Tammesoo; Abdonas Tamosiunas; Eng Joo Tan; Xun Tang; Frank Tanser; Yong Tao; Mohammed Rasoul Tarawneh; Carolina B Tarqui-Mamani; Oana-Florentina Tautu; Anne Taylor; Holger Theobald; Xenophon Theodoridis; Lutgarde Thijs; Betina H Thuesen; Anne Tjonneland; Hanna K Tolonen; Janne S Tolstrup; Murat Topbas; Roman Topór-Madry; María José Tormo; Maties Torrent; Pierre Traissac; Dimitrios Trichopoulos; Antonia Trichopoulou; Oanh T H Trinh; Atul Trivedi; Lechaba Tshepo; Marshall K Tulloch-Reid; Fikru Tullu; Tomi-Pekka Tuomainen; Jaakko Tuomilehto; Maria L Turley; Per Tynelius; Christophe Tzourio; Peter Ueda; Eunice E Ugel; Hanno Ulmer; Hannu M T Uusitalo; Gonzalo Valdivia; Damaskini Valvi; Yvonne T van der Schouw; Koen Van Herck; Hoang Van Minh; Lenie van Rossem; Natasja M Van Schoor; Irene G M van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Lars Vatten; Tomas Vega; Gustavo Velasquez-Melendez; Giovanni Veronesi; W M Monique Verschuren; Roosmarijn Verstraeten; Cesar G Victora; Lucie Viet; Eira Viikari-Juntura; Paolo Vineis; Jesus Vioque; Jyrki K Virtanen; Sophie Visvikis-Siest; Bharathi Viswanathan; Tiina Vlasoff; Peter Vollenweider; Sari Voutilainen; Alisha N Wade; Aline Wagner; Janette Walton; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Rildo S Wanderley; Ming-Dong Wang; Qian Wang; Ya Xing Wang; Ying-Wei Wang; S Goya Wannamethee; Nicholas Wareham; Niels Wedderkopp; Deepa Weerasekera; Peter H Whincup; Kurt Widhalm; Indah S Widyahening; Andrzej Wiecek; Alet H Wijga; Rainford J Wilks; Johann Willeit; Peter Willeit; Emmanuel A Williams; Tom Wilsgaard; Bogdan Wojtyniak; Roy A Wong-McClure; Justin Y Y Wong; Tien Yin Wong; Jean Woo; Mark Woodward; Aleksander Giwercman Wu; Frederick C Wu; Shouling Wu; Haiquan Xu; Weili Yan; Xiaoguang Yang; Xingwang Ye; Panayiotis K Yiallouros; Akihiro Yoshihara; Novie O Younger-Coleman; Ahmad Faudzi Yusoff; Ahmad Ali Zainuddin; Sabina Zambon; Antonis Zampelas; Tomasz Zdrojewski; Yi Zeng; Dong Zhao; Wenhua Zhao; Wei Zheng; Yingfeng Zheng; Dan Zhu; Baurzhan Zhussupov; Esther Zimmermann; Julio Zuñiga Cisneros
    International Journal of Epidemiology 47 3 872 - 883i 2018年06月 [査読有り]
  • Katsuyasu Kouda; Kumiko Ohara; Yuki Fujita; Harunobu Nakamura; Takahiro Tachiki; Masayuki Iki
    Journal of Bone and Mineral Metabolism 1 - 9 2018年02月 [査読有り]
     
    Leptin regulates bone cell differentiation and functions via direct and indirect actions in experimental settings. Epidemiologically, however, the impact of leptin on the regulation of bone metabolism remains unclear. While some studies have reported a positive relationship between leptin and bone mineral parameters, other studies found an inverse or no association. We analyzed data from a population-based follow-up survey of community-dwelling children in Hamamatsu, Japan, to investigate relationships between leptin levels and bone mineral parameters. Multiple regression analysis was performed. Multicollinearity was quantified using the variance infiltration factor (VIF). Among 408 children who participated in the baseline survey (at age 11.2 years), 254 (121 boys and 133 girls) completed the follow-up survey (at age 14.2 years). Leptin levels were strongly related to fat mass (r = 0.87 in boys, r = 0.80 in girls). Leptin levels at baseline were significantly (P < 0.05) positively related to total body less head (TBLH) areal bone mineral density (aBMD) at follow-up in girls (standardized partial regression coefficient: β = 0.302, VIF = 2.246), after adjusting for body fat percentage (%). On the other hand, leptin levels were inversely related to TBLH aBMD in boys (β = − 0.395, VIF = 4.116), after adjusting for body fat mass (kg). Positive relationships between leptin levels and bone mineral parameters were observed with VIF values < 4.0, whereas inverse relationships were observed with VIF values ≥ 4.0. These findings suggest that positive relationships between leptin levels and bone mineral parameters are weak, or not always observed, due to statistical problems (i.e., multicollinearity) and other factors derived from adipose tissue.
  • Katsuyasu Kouda; Kumiko Ohara; Harunobu Nakamura; Yuki Fujita; Myadagmaa Jaalkhorol; Masayuki Iki
    Bone 107 222 - 227 2018年02月 [査読有り]
     
    The independent impact of fat mass (FM) on bone health is difficult to assess, as FM is correlated with lean soft tissue mass (LSTM). In a previous cross-sectional study, FM was suggested to help promote high bone mass acquisition in adolescents with small LSTM. The present prospective cohort study investigated the effects of FM on bone in pubertal children after stratification by height-normalized index of LSTM (LSTMI). The source population was all 5th grade children enrolled in either one of the two public elementary schools in Hamamatsu, Japan. Of these, 545 children who participated in both baseline (at age 11) and follow-up (at age 14) surveys were included in the present analysis. Body composition and whole body areal bone mineral density (aBMD) were measured using dual-energy X-ray absorptiometry. From baseline to follow-up, significant (P < 0.05) differences were observed in changes in aBMD among tertiles of change in FM in both sexes after adjusting for confounding factors including LSTMI. After stratification by tertiles of sex-specific LSTMI, adjusted means of changes in aBMD according to tertiles of change in FM within the lowest and second lowest tertiles of LSTMI in both sexes showed a significant increase from the lower tertiles to the highest tertile of change in FM. In the highest tertile of LSTMI, changes in FM showed no significant association with changes in aBMD. These findings suggest that adipose tissue might help promote high bone mass acquisition in pubertal children with small or normal LSTMI.
  • Junko Tamaki; Katsuyasu Kouda; Yuki Fujita; Masayuki Iki; Akiko Yura; Masakazu Miura; Yuho Sato; Nozomi Okamoto; Norio Kurumatani
    Journal of Clinical Endocrinology and Metabolism 103 1 85 - 94 2018年 [査読有り]
     
    Context: Although the endogenous secretory receptor for advanced glycation end products (esRAGE) has been associated with reduced activity of pentosidine (PEN), the association between PEN, esRAGE, and fracture is poorly understood. Objectives: To evaluate the ability of serum PEN and esRAGE levels to predict fragility fractures. Methods: A cohort of 1285 Japanese men aged $65 years old participated in a 2007 to 2008 Fujiwara-kyo Osteoporosis Risk in Men study baseline survey, as part of the Fujiwara-kyo prospective cohort study. Those participants provided information regarding any fractures they experienced during 5 years. The baseline bone mineral density (BMD) was measured. Hazard ratios (HRs) per one standard deviation increase of log-transformed serum levels of PEN, esRAGE, and esRAGE-to-PEN ratio were estimated at baseline. Results: Twenty-five participating men suffered incident clinical fragility fractures. The crude HRs (95% confidence interval) for PEN, esRAGE, and esRAGE-to-PEN ratio were 1.56 (1.05 to 2.31), 0.79 (0.54 to 1.15), and 0.65 (0.44 to 0.95), respectively. HRs for PEN adjusted for age, esRAGE, and T score of BMD at femoral neck (FN) and lumbar spine (LS) were 1.48 (1.00 to 2.18) and 1.51 (1.03 to 2.21), respectively. The marginal significance adjusted for BMD at FN and the statistical significance adjusted for BMD at LS were attenuated after additional adjustment for glycated hemoglobin A1c level (P = 0.111 and 0.072, respectively). The HRs for esRAGE-to-PEN ratio adjusted for age, glycated hemoglobin A1c, and T-score of BMD at FN and LS were 0.67 (0.45 to 0.98) and 0.64 (0.43 to 0.95). Conclusions: Higher esRAGE-to-PEN ratios were associated with decreased risk of fragility fractures independent of BMD among elderly Japanese men. (J Clin Endocrinol Metab 103: 85–94, 2018)
  • Masanori Yoshikawa; Yoshifumi Yamamoto; Koichi Tomoda; Yukio Fujita; Motoo Yamauchi; Takao Osa; Hiroki Uyama; Nozomi Okamoto; Norio Kurumatani; Hiroshi Kimura
    GERIATRICS & GERONTOLOGY INTERNATIONAL 17 12 2421 - 2426 2017年12月 [査読有り]
     
    AimAs the Japanese population ages, the number of older patients with chronic obstructive pulmonary disease (COPD) is expected to increase, but the prevalence of COPD in patients aged 80years remains unclear. The purpose of the present study was to determine the prevalence of COPD in independent community-dwelling older adults aged 80years. MethodsWe investigated the prevalence of COPD in 2862 independent community-dwelling older adults (1504 men, 1358 women, mean age 77.77.0years) who underwent spirometry in the Fujiwara-kyo study, a study of successful aging in older adults. Those participants with airflow limitation (forced expiratory volume in 1s/forced vital capacity <0.7) who indicated on a self-administered questionnaire that they had a history of smoking and did not have bronchial asthma were considered to have COPD. ResultsThe prevalence of COPD was 16.9% among all participants and 37.4% among smokers. The prevalence among individuals aged 80years (19.7%) was significantly higher than that among those aged <80years (16.0%; P<0.05). When forced expiratory volume in 1s/forced vital capacity lower limit of normal was used as the criterion for airflow limitation, the prevalence fell to 11.0%. Patients with mild-to-moderate airflow limitation (stageI/stageII) accounted for the great majority (91.2%) of COPD patients aged 80years. ConclusionsA high prevalence of mild-to-moderate COPD was observed even in the independent community-dwelling older adults aged 80years. However, the benefits of the spirometric screening and treatment for these patients needs to be determined. Geriatr Gerontol Int 2017; 17: 2421-2426.
  • NCD Risk Factor Collaboration; NCD-RisC
    Lancet (London, England) 390 10113 2627 - 2642 2017年12月 [査読有り]
     
    Background Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. Methods We pooled 2416 population-based studies with measurements of height and weight on 128.9 million participants aged 5 years and older, including 31.5 million aged 5-19 years. We used a Bayesian hierarchical model to estimate trends from 1975 to 2016 in 200 countries for mean BMI and for prevalence of BMI in the following categories for children and adolescents aged 5-19 years: more than 2 SD below the median of the WHO growth reference for children and adolescents (referred to as moderate and severe underweight hereafter), 2 SD to more than 1 SD below the median (mild underweight), 1 SD below the median to 1 SD above the median (healthy weight), more than 1 SD to 2 SD above the median (overweight but not obese), and more than 2 SD above the median (obesity). Findings Regional change in age-standardised mean BMI in girls from 1975 to 2016 ranged from virtually no change (-0.01 kg/m (2) per decade; 95% credible interval -0.42 to 0.39, posterior probability [PP] of the observed decrease being a true decrease= 0.5098) in eastern Europe to an increase of 1.00 kg/m(2) per decade (0.69-1.35, PP> 0.9999) in central Latin America and an increase of 0.95 kg/m (2) per decade (0.64-1.25, PP> 0.9999) in Polynesia and Micronesia. The range for boys was from a non-significant increase of 0.09 kg/m(2) per decade (-0.33 to 0.49, PP= 0.6926) in eastern Europe to an increase of 0.77 kg/m (2) per decade (0.50-1.06, PP> 0.9999) in Polynesia and Micronesia. Trends in mean BMI have recently flattened in northwestern Europe and the high-income English-speaking and Asia-Pacific regions for both sexes, southwestern Europe for boys, and central and Andean Latin America for girls. By contrast, the rise in BMI has accelerated in east and south Asia for both sexes, and southeast Asia for boys. Global age-standardised prevalence of obesity increased from 0.7% (0.4-1.2) in 1975 to 5.6% (4.8-6.5) in 2016 in girls, and from 0.9% (0.5-1.3) in 1975 to 7.8% (6.7-9.1) in 2016 in boys; the prevalence of moderate and severe underweight decreased from 9.2% (6.0-12.9) in 1975 to 8.4% (6.8-10.1) in 2016 in girls and from 14.8% (10.4-19.5) in 1975 to 12.4% (10.3-14.5) in 2016 in boys. Prevalence of moderate and severe underweight was highest in India, at 22.7% (16.7-29.6) among girls and 30.7% (23.5-38.0) among boys. Prevalence of obesity was more than 30% in girls in Nauru, the Cook Islands, and Palau; and boys in the Cook Islands, Nauru, Palau, Niue, and American Samoa in 2016. Prevalence of obesity was about 20% or more in several countries in Polynesia and Micronesia, the Middle East and north Africa, the Caribbean, and the USA. In 2016, 75 (44-117) million girls and 117 (70-178) million boys worldwide were moderately or severely underweight. In the same year, 50 (24-89) million girls and 74 (39-125) million boys worldwide were obese. Interpretation The rising trends in children's and adolescents' BMI have plateaued in many high-income countries, albeit at high levels, but have accelerated in parts of Asia, with trends no longer correlated with those of adults.
  • Masayuki Iki; Yuki Fujita; Katsuyasu Kouda; Akiko Yura; Takahiro Tachiki; Junko Tamaki; Renaud Winzenrieth; Yuho Sato; Jong-Seong Moon; Nozomi Okamoto; Norio Kurumatani
    BONE 105 18 - 25 2017年12月 [査読有り]
     
    Purpose: Patients with type 2 diabetes mellitus (T2DM) have an increased fracture risk despite having higher areal bone mineral density (aBMD). This study aimed to clarify the association between glycemic and insulin resistance status and bone microarchitecture, and whether pentosidine and bone turnover markers play any roles in the association. Methods: A total of 2012 community-dwelling men aged 65 years completed baseline measurements of spine aBMD, fasting plasma glucose (FPG) and serum insulin, hemoglobin A1c (HbA1c), osteocalcin, type I procollagen N-terminal propeptide, type I collagen C-terminal crosslinking telopeptide, tartrate-resistant acid phosphatase isoenzyme 5b, pentosidine, height and weight and an interview regarding past disease history. Homeostasis model assessment-insulin resistance (HOMA-IR) was also calculated. T2DM was defined as physician-diagnosed middle age or elderly-onset diabetes mellitus, or according to biochemical test results. To evaluate bone microarchitecture, trabecular bone score (TBS) was calculated at the same vertebrae as those used for aBMD measurement. Results: After excluding participants who had a disease history and/or were taking medications affecting bone metabolism, 1683 men (age, 72.9 +/- 5.2 years) were analyzed. Men with T2DM had significantly higher aBMD compared to those without T2DM. There was no significant difference in TBS. However, FPG, HbA1c and HOMA-IR levels were significantly inversely correlated with TBS after adjusting for age, BMI and aBMD. Multivariate linear regression analyses revealed that glycemic indices (FPG and HbA1c) were significantly associated with increased aBMD and decreased TBS, and that HOMA-IR was associated only with TBS. These associations did not change after further adjusting for bone turnover makers and pentosidine levels. Conclusions: Hyperglycemia and elevated insulin-resistance were associated with low TBS independently of bone turnover and pentosidine levels. (C) 2017 Elsevier Inc. All rights reserved.
  • M. Iki; Y. Fujita; J. Tamaki; K. Kouda; A. Yura; Y. Sato; J. S. Moon; A. Harano; K. Hazaki; E. Kajita; M. Hamada; K. Arai; K. Tomioka; N. Okamoto; N. Kurumatani
    OSTEOPOROSIS INTERNATIONAL 28 3 871 - 880 2017年03月 [査読有り]
     
    Frail elderly individuals have elevated risks of both fracture and mortality. We found that incident fractures were associated with an increased risk of death even after adjusting for pre-fracture frailty status as represented by physical performance tests and laboratory tests for common geriatric diseases in community-dwelling elderly Japanese men. While fractures reportedly increase the risk of mortality, frailty may complicate this association, generating a false-positive result. We evaluated this association after adjusting for pre-fracture levels of frailty. We examined 1998 community-dwelling ambulatory men aged >= 65 years at baseline in the Fujiwara-kyo Osteoporosis Risk in Men Study for frailty status as represented by activities of daily living (ADL), physical performance tests (grip strength, one-foot standing balance with eyes open, timed 10-m walk), and laboratory sera tests. Participants were then followed for 5 years for incident clinical fractures and death. Effects of incident fracture on death were determined by Cox proportional hazards model with the first fracture during follow-up as a time-dependent predictor and with frailty status indices as covariates. We identified 111 fractures in 99 men and 138 deaths during the follow-up period (median follow-up, 4.5 years). Participants with incident fractures did not have significantly worse frailty statuses, but did show a significantly higher cumulative mortality rate than those without fractures (p = 0.0047). Age-adjusted hazard ratio (HR) of death for incident fracture was 3.57 (95 % confidence interval: 2.05, 6.24). When adjusted for physical performance, this decreased to 2.77 (1.51, 5.06), but remained significant. The HR showed no significant change when adjusted for laboratory test results (3.96 (2.26, 6.94)). Exclusion of deaths within the first 24 months of follow-up did not alter these results. Incident clinical fracture was associated with an elevated risk of death independently of pre-fracture levels of frailty in community-dwelling elderly men.
  • Katsuyasu Kouda; Kumiko Ohara; Harunobu Nakamura; Yuki Fujita; Masayuki Iki
    JOURNAL OF BONE AND MINERAL METABOLISM 35 2 185 - 191 2017年03月 [査読有り]
     
    Although most adult bone mass is acquired before adolescence, only a few studies have assessed bone turnover markers in children. Thus, the utility of bone markers to evaluate and predict bone mineral accrual in children is unclear. The present study assessed the association between serum bone markers at 11 years of age and subsequent changes in bone gain. Information on bone minerals and bone markers at baseline and at the 3-year follow- up were obtained from 121 children who registered as fifth-grade students in 2010, in Hamamatsu, Japan. Wholebody bone mineral content (WBBMC) and whole-body bone mineral density (WBBMD) were measured using dual-energy X-ray absorptiometry. Boys showed significant (P < 0.05) positive relationships between intact osteocalcin at baseline and WBBMC at follow-up (beta = 0.24), between tartrate-resistant acid phosphatase isoenzyme 5b (TRAP5b) and WBBMC (beta = 0.34), and between TRAP5b and WBBMD (beta = 0.34), after adjusting for potential confounding factors. In girls, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of type 1 collagen crosslinked C-terminal telopeptide. In boys, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of TRAP5b. Children with a high concentration of bone turnover markers tended to exhibit substantial accrual of bone minerals. These results suggest that serum levels of circulating biomarkers at age 11 predict subsequent bone mineral accrual.
  • NCD Risk Factor Collaboration; NCD-RisC
    Lancet (London, England) 389 10064 37 - 55 2017年01月 [査読有り]
     
    Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19.1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127.0 mm Hg (95% credible interval 125.7-128.3) in men and 122.3 mm Hg (121.0-123.6) in women; age-standardised mean diastolic blood pressure was 78.7 mm Hg (77.9-79.5) for men and 76.7 mm Hg (75.9-77.6) for women. Global age-standardised prevalence of raised blood pressure was 24.1% (21.4-27.1) in men and 20.1% (17.8-22.5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1.13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence. Interpretation During the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe. Funding Wellcome Trust. Copyright (C) The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license.
  • Katsuyasu Kouda; Harunobu Nakamura; Kumiko Ohara; Yuki Fujita; Masayuki Iki
    JOURNAL OF CLINICAL DENSITOMETRY 20 1 66 - 72 2017年01月 [査読有り]
     
    Very few epidemiological studies have examined the relative impact of visceral fat and subcutaneous fat on serum adiponectin levels. Trunk-to-extremity fat ratio is reportedly a better surrogate for visceral fat than for subcutaneous fat. In the present study, we investigated the association between adiponectin and trunk-to-appendicular fat ratio (TAR) in a school population. The source population was all fifth graders (799 pupils) enrolled in the 2 elementary schools in Hamamatsu, Japan. Of the source population, we analyzed cross-sectional data from 609 children (mean age: 11.2 yr). TAR was evaluated by dual-energy X-ray absorptiometry and calculated as trunk fat mass divided by appendicular (arms and legs) fat mass. After stratification by tertiles of total body fat, multiple regression analysis was used to examine the relationships between adiponectin and TAR adjusted for potential confounding factors. In the highest tertile of total body fat, increasing TARs were significantly (p < 0.05) associated with decreasing serum adiponectin levels after stratification by total body fat (beta = -0.32 in boys; beta = -0.31 in girls). In the second tertile of total body fat, TAR in girls also showed significant inverse relationships with serum adiponectin levels (beta = -0.27). Data from this population-based study demonstrated that an increased proportion of trunk fat is associated with decreased adiponectin in relatively overweight children, and also demonstrated that girls with a normal volume of body fat that follows a more centralized distribution show decreased adiponectin.
  • Katsuyasu Kouda; Kumiko Ohara; Yuki Fujita; Harunobu Nakamura; Masayuki Iki
    CIRCULATION JOURNAL 80 8 1838 - 1845 2016年08月 [査読有り]
     
    Background: Only a few studies have examined the relationship between fat distribution measured by dual-energy X-ray absorptiometry (DXA) and blood pressure (BP), and no cohort study has targeted a pediatric population. Methods and Results: The source population comprised all students registered as fifth graders in the 2 elementary schools in Hamamatsu, Japan. Of these, 258 children participated in both baseline (at age 11) and follow-up (at age 14) surveys. Body fat distribution was assessed using trunk-to-appendicular fat ratio (TAR) and trunk-to-leg fat ratio (TLR) measured by DXA. Relationships between BP levels and fat distribution (TAR or TLR) were examined after stratification by tertiles of whole-body fat. Systolic BP at follow-up was significantly (P<0.05) associated with both TAR (boys, beta=0.33; girls beta=0.36) and TLR (girls beta=0.35) at baseline, after adjusting for confounding factors such as baseline BP in the lowest tertile of whole-body fat. Moreover, adjusted means of systolic and diastolic BPs in girls showed a significant increase from the lowest to highest tertile of TAR within the lowest tertile of whole-body fat. Conclusions: Body fat distribution in childhood could predict subsequent BP levels in adolescence. Children with a relatively low body fat that is more centrally distributed tended to show relatively high BP later on.
  • James Bentham; Mariachiara Di Cesare; Gretchen A. Stevens; Bin Zhou; Honor Bixby; Melanie Cowan; Lea Fortunato; James E. Bennett; Goodarz Danaei; Kaveh Hajifathalian; Yuan Lu; Leanne M. Riley; Avula Laxmaiah; Vasilis Kontis; Christopher J. Paciorek; Elio Riboli; Majid Ezzati; Ziad A. Abdeen; Zargar Abdul Hamid; Niveen M. Abu-Rmeileh; Benjamin Acosta-Cazares; Robert Adams; Wichai Aekplakorn; Carlos A. Aguilar-Salinas; Charles Agyemang; Alireza Ahmadvand; Wolfgang Ahrens; Hazzaa M. Al-Hazzaa; Amani Rashed Al-Othman; Rajaa Al Raddadi; Mohamed M. Ali; Ala'a Alkerwi; Mar Alvarez-Pedrerol; Eman Aly; Philippe Amouyel; Antoinette Amuzu; Lars Bo Andersen; Sigmund A. Anderssen; Ranjit Mohan Anjana; Hajer Aounallah-Skhiri; Inger Ariansen; Tahir Aris; Nimmathota Arlappa; Dominique Arveiler; Felix K. Assah; Maria Avdicova; Fereidoun Azizi; Bontha V. Babu; Suhad Bahijri; Nagalla Balakrishna; Piotr Bandosz; Jose R. Banegas; Carlo M. Barbagallo; Alberto Barcelo; Amina Barkat; Mauro V. Barros; Iqbal Bata; Anwar M. Batieha; Rosangela L. Batista; Louise A. Baur; Robert Beaglehole; Habiba Ben Romdhane; Mikhail Benet; James E. Bennett; Antonio Bernabe-Ortiz; Gailute Bernotine; Heloisa Bettiol; Aroor Bhagyalaxmi; Sumit Bharadwaj; Santosh K. Bhargava; Zaid Bhatti; Zulfiqar A. Bhutta; Hongsheng Bi; Yufang Bi; Peter Bjerregaard; Espen Bjertness; Marius B. Bjertness; Cecilia Bjorkelund; Anneke Blokstra; Simona Bo; Martin Bobak; Lynne M. Boddy; Bernhard O. Boehm; Heiner Boeing; Carlos P. Boissonnet; Vanina Bongard; Pascal Bovet; Lutgart Braeckman; Marjolijn C. E. Bragt; Imperia Brajkovich; Francesco Branca; Juergen Breckenkamp; Hermann Brenner; Lizzy M. Brewster; Garry R. Brian; Graziella Bruno; H. B(as) Bueno-de-Mesquita; Anna Bugge; Con Burns; Antonio Cabrera de Leon; Joseph Cacciottolo; Tilema Cama; Christine Cameron; Jose Camolas; Gunay Can; Ana Paula C. Candido; Vincenzo Capuano; Viviane C. Cardoso; Axel C. Carlsson; Maria J. Carvalho; Felipe F. Casanueva; Juan-Pablo Casas; Carmelo A. Caserta; Snehalatha Chamukuttan; Angelique W. Chan; Queenie Chan; Himanshu K. Chaturvedi; Nishi Chaturvedi; Chien-Jen Chen; Fangfang Chen; Huashuai Chen; Shuohua Chen; Zhengming Chen; Ching-Yu Cheng; Angela Chetrit; Arnaud Chiolero; Shu-Ti Chiou; Adela Chirita-Emandi; Belong Cho; Yumi Cho; Kaare Christensen; Jerzy Chudek; Renata Cifkova; Frank Claessens; Els Clays; Hans Concin; Cyrus Cooper; Rachel Cooper; Tara C. Coppinger; Simona Costanzo; Dominique Cottel; Chris Cowell; Cora L. Craig; Ana B. Crujeiras; Graziella D'Arrigo; Eleonora d'Orsi; Jean Dallongeville; Albertino Damasceno; Camilla T. Damsgaard; Goodarz Danaei; Rachel Dankner; Luc Dauchet; Guy De Backer; Dirk De Bacque; Giovanni de Gaetano; Stefaan De Hanauw; Delphine De Smedt; Mohan Deepa; Alexander D. Deev; Abbas Dehghan; Helene Delisle; Francis Delpeuch; Valerie Deschamps; Klodian Dhana; Augusto F. Di Castelnuovo; Juvenal Soares Dias-da-Costa; Alejandro Diaz; Shirin Djalalinia; Ha T. P. Do; Annette J. Dobson; Chiara Donfrancesco; Silvana P. Donoso; Angela Doering; Kouamelan Doua; Wojciech Drygas; Vilnis Dzerve; Eruke E. Egbagbe; Robert Eggertsen; Ulf Ekelund; Jalila El Ati; Paul Elliott; Reina Engle-Stone; Rajiv T. Erasmus; Cihangir Erem; Loise Eriksen; Jorge Escobedo-de la Pena; Alun Evans; David Faeh; Caroline H. Fall; Farshad Farzadfar; Francisco J. Felix-Redondo; Trevor S. Ferguson; Daniel Fernandez-Berges; Daniel Ferrante; Marika Ferrari; Catterina Ferreccio; Jean Ferrieres; Joseph D. Finn; Krista Fischer; Eric Monterubio Flores; Bernhard Foeger; Leng Huat Foo; Ann-Sofie Forslund; Maria Forsner; Stephen P. Fortmann; Heba M. Francis; Damian K. Francis; Maria do Carmo Franco; Oscar H. Franco; Guillermo Frontera; Flavio D. Fuchs; Sandra C. Fuchs; Yuki Fujita; Takuro Furusawa; Takuro Furusawa; Zbigniew Gaciong; Mihai Gafencu; Dickman Gareta; Sarah P. Garnett; Jean-Michel Gaspoz; Magda Gasull; Louise Gates; Johanna M. Geleijnse; Anoosheh Ghasemian; Simona Giampaoli; Francesco Gianfagna; Jonathan Giovannelli; Aleksander Giwercman; Rebecca A. Goldsmith; Helen Goncalves; Marcela Gonzalez Gross; Juan P. Gonzalez Rivas; Mariano Bonet Gorbea; Frederic Gottrand; Sidsel Graff-Iversen; Dusan Grafnetter; Aneta Grajda; Maria G. Grammatikopoulou; Ronald D. Gregor; Tomasz Grodzicki; Anders Grontved; Grabriella Gruden; Vera Grujic; Dongfeng Gu; Emanuela Gualdi-Russo; Ong Peng Guan; Vilmundur Gudnason; Ramiro Guerrero; Idris Guessous; Andre L. Guimaraes; Martin C. Gulliford; Johanna Gunnlaugsdottir; Marc Gunter; Xiuhua Guo; Yin Guo; Prakash C. Gupta; Oye Gureje; Beata Gurzkowska; Laura Gutierrez; Felix Gutzwiller; Jytte Halkjaer; Ian R. Hambleton; Rebecca Hardy; Rachakulla Hari Kumar; Jun Hata; Alison J. Hayes; Jiang He; Marleen Ekisabeth Hendriks; Leticia Hernandez Cadena; Sauli Herrala; Ramin Heshmat; Ilpo Tapani Hihtaniemi; Sai Yin Ho; Suzanne C. Ho; Michael Hobbs; Albert Hofman; Claudi M. Hormiga; Bernardo L. Horta; Leila Houti; Christina Howitt; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; Yonghua Hu; Abdullatif Husseini; Chinh Nguyen Huu; Inge Huybrechts; Nahla Hwalla; Licia Iacoviello; Anna G. Iannone; Mohsen M. Ibrahim; Nayu Ikeda; M. Arfan Ikram; Vilma E. Irazola; Muhammad Islam; Vanja Ivkovic; Masanori Iwasaki; Rod T. Jackson; Jeremy M. Jacobs; Tazeen Jafar; Kazi M. Jamil; Konrad Jamrozik; Imre Janszky; Grazyna Jasienska; Bojan Jelakovic; Chao Qiang Jiang; Michel Joffres; Mattias Johansson; Jost B. Jonas; Torben Jorgensen; Pradeep Joshi; Anne Juolevi; Gregor Jurak; Vesno Juresa; Rudolf Kaaks; Anthony Kafatos; Ofra Kalter-Leibovici; Efthymios Kapantais; Amir Kasaeian; Joanne Katz; Prabhdeep Kaur; Maryam Kavousi; Ulrich Keil; Lital Keinan Boker; Sirkka Keinanen-Kiukaanniemi; Roya Kelishadi; Han C. G. Kemper; Andre P. Kengne; Mathilde Kersting; Timothy Key; Yousef Saleh Khader; Davood Khalili; Young-Ho Khang; Kay-Tee H. Khaw; Ilse M. S. L. Khouw; Stefan Kiechl; Japhet Killewo; Jeongseon Kim; Jeannette Klimont; Jurate Klumbiene; Bhawesh Koirala; Elin Kolle; Patrick Kolsteren; Paul Korrovits; Seppo Koskinen; Katsuyasu Kouda; Slawomir Koziel; Wolfgang Kratzer; Steinar Krokstad; Daan Kromhout; Herculina S. Kruger; Ruzena Kubinova; Urho M. Kujala; Krzysztof Kula; Zbigniew Kulaga; R. Krishna Kumar; Pawel Kurjata; Yadlapalli S. Kusuma; Kari Kuulasmaa; Catherine Kyobutungi; Fatima Zahra Laamiri; Tiina Laatikainen; Carl Lachat; Youcef Laid; Tai Hing Lam; Orlando Landrove; Vera Lanska; Georg Lappas; Bagher Larijani; Lars E. Laugsand; Avula Laxmaiah; Khanh Le Nguyen Bao; Tuyen D Le; Catherine Leclercq; Jeannette Lee; Jeonghee Lee; Terho Lehtimaki; Rampal Lekhraj; Luz M. Leon-Munoz; Yanping Li; Christa L. Lilly; Wei-Yen Lim; M. Fernanda Lima-Costa; Hsien-Ho Lin; Xu Lin; Allan Linneberg; Lauren Lissner; Mieczyslaw Litwin; Jing Liu; Roberto Lorbeer; Paulo A. Lotufo; Jose Eugenio Lozano; Dalia Luksiene; Annamari Lundqvist; Nuno Lunet; Guansheng Ma; Jun Ma; George L. L. Machado-Coelho; Suka Machi; Stefania Maggi; Dianna J. Magliano; Bernard Maire; Marcia Makdisse; Reza Malekzadeh; Rahul Malhotra; Kodavanti Mallikharjuna Rao; Sofia Malyutina; Yannis Manios; Jim I. Mann; Enzo Manzato; Paula Margozzini; Oonagh Markey; Pedro Marques-Vidal; Jaume Marrugat; Yves Martin-Prevel; Reynaldo Martorell; Shariq R. Masoodi; Ellisiv B. Mathiesen; Tandi E. Matsha; Artur Mazur; Jean Claude N. Mbanya; Shelly R. McFarlane; Stephen T. McGarvey; Martin McKee; Stela McLachlan; Rachael M. McLean; Breige A. McNulty; Safiah Md Yusof; Sounnia Mediene-Benchekor; Aline Meirhaeghe; Christa Meisinger; Ana Maria B. Menezes; Gert B. M. Mensink; Indrapal I. Meshram; Andres Metspalu; Jie Mi; Kim F. Michaelsen; Kairit Mikkel; Jody C. Miller; Juan Francisco Miquel; J. Jaime Miranda; Marjeta Misigoj-Durakovic; Mostafa K. Mohamed; Kazem Mohammad; Noushin Mohammadifard; Viswanathan Mohan; Muhammad Fadhli Mohd Yusoff; Drude Molbo; Niels C. Moller; Denes Molnar; Charles K. Mondo; Eric A. Monterrubio; Kotsedi Daniel K. Monyeki; Leila B. Moreira; Alain Morejon; Luis A. Moreno; Karen Morgan; Erik Lykke Mortensen; George Moschonis; Malgorzata Mossakowska; Aya Mostafa; Jorge Mota; Mohammad Esmaeel Motlagh; Jorge Motta; Thet Thet Mu; Maria Lorenza Muiesan; Martina Mueller-Nurasyid; Neil Murphy; Jaakko Mursu; Elaine M. Murtagh; Kamarul Imran Musa; Vera Musil; Gabriele Nagel; Harunobu Nakamura; Jana Namesna; Ei Ei K. Nang; Vinay B. Nangia; Martin Nankap; Sameer Narake; Eva Maria Navarrete-Munoz; William A. Neal; Ilona Nenko; Martin Neovius; Flavio Nervi; Hannelore K. Neuhauser; Nguyen D. Nguyen; Quang Ngoc Nguyen; Ramfis E. Nieto-Martinez; Guang Ning; Toshiharu Ninomiya; Sania Nishtar; Marianna Noale; Teresa Norat; Davide Noto; Mohannad Al Nsour; Dermot O'Reilly; Kyungwon Oh; Iman H. Olayan; Maria Teresa Anselmo Olinto; Maciej Oltarzewski; Mohd A. Omar; Altan Onat; Pedro Ordunez; Ana P. Ortiz; Merete Osler; Clive Osmond; Sergej M. Ostojic; Johanna A. Otero; Kim Overvad; Ellis Owusu-Dabo; Fred Michel Paccaud; Cristina Padez; Elena Pahomova; Andrzej Pajak; Domenico Palli; Alberto Palloni; Luigi Palmieri; Songhomitra Panda-Jonas; Francesco Panza; Winsome R. Parnell; Mahboubeh Parsaeian; Ivan Pecin; Mangesh S. Pednekar; Petra H. Peeters; Sergio Viana Peixoto; Markku Peltonen; Alexandre C. Pereira; Cynthia M. Perez; Annette Peters; Janina Petkeviciene; Niloofar Peykari; Son Thai Pham; Iris Pigeot; Hynek Pikhart; Aida Pilav; Lorenza Pilotto; Francesco Pistelli; Freda Pitakaka; Aleksandra Piwonska; Pedro Plans-Rubio; Bee Koon Poh; Miquel Porta; Marileen L. P. Portegies; Dimitrios Poulimeneas; Rajendra Pradeepa; Mathur Prashant; Jacqueline F. Price; Maria Puiu; Margus Punab; Radwan F. Qasrawi; Mostafa Qorbani; Tran Quoc Bao; Ivana Radic; Ricardas Radisauskas; Mahmudur Rahman; Olli Raitakari; Manu Raj; Sudha Ramachandra Rao; Ambady Ramachandran; Jacqueline Ramke; Rafel Ramos; Sanjay Rampal; Finn Rasmussen; Josep Redon; Paul Ferdinand M. Reganit; Robespierre Ribeiro; Elio Riboli; Fernando Rigo; Tobias F. Rinke de Wit; Raphael M. Ritti-Dias; Juan A. Rivera; Sian M. Robinson; Cynthia Robitaille; Fernando Rodri-guez-Artalejo; Maria del Cristo Rodriguez-Perez; Laura A. Rodriguez-Villamizar; Rosalba Rojas-Martinez; Nipa Rojroongwasinkul; Dora Romaguera; Kimmo Ronkainen; Annika Rosengren; Ian Rouse; Adolfo Rubinstein; Frank J. Ruhli; Ornelas Rui; Blanca Sandra Ruiz-Betancourt; Andrea R. V. Russo Horimoto; Marcin Rutkowski; Charumathi Sabanayagam; Harshpal S. Sachdev; Olfa Saidi; Benoit Salanave; Eduardo Salazar Martinez; Veikko Salomaa; Jukka T. Salonen; Massimo Salvetti; Jose Sanchez-Abanto; Sandjaja; Susana Sans; Diana A. Santos; Osvaldo Santos; Renata Nunes dos Santos; Rute Santos; Jouko L. Saramies; Luis B. Sardinha; Nizal Sarrafzadegan; Kai-Uwe Saum; Savvas C. Savva; Marcia Scazufca; Angelika Schaffrath Rosario; Herman Schargrodsky; Anja Schienkiewitz; Ida Maria Schmidt; Ione J. Schneider; Constance Schultsz; Aletta E. Schutte; Aye Aye Sein; Abhijit Sen; Idowu O. Senbanjo; Sadaf G. Sepanlou; Svetlana A. Shalnova; Sanjib K. Sharma; Jonathan E. Shaw; Kenji Shibuya; Dong Wook Shin; Youchan Shin; Rahman Shiri; Rosalynn Siantar; Abla M. Sibai; Antonio M. Silva; Diego Augusto Santos Silva; Mary Simon; Judith Simons; Leon A. Simons; Michael Sjostrom; Jolanta Slowikowska-Hilczer; Przemyslaw Slusarczyk; Liam Smeeth; Margaret C. Smith; Marieke B. Snijder; Hung-Kwan So; Eugene Sobngwi; Stefan Soderberg; Moesijanti Y. E. Soekatri; Vincenzo Solfrizzi; Emily Sonestedt; Yi Song; Thorkild I. A. Sorensen; Maroje Soric; Charles Sossa Jerome; Aicha Soumare; Jan A. Staessen; Gregor Starc; Maria G. Stathopoulou; Kaspar Staub; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D. Stein; George S. Stergiou; Jochanan Stessman; Jutta Stieber; Doris Stoeckl; Tanja Stocks; Jakub Stokwiszewski; Gareth Stratton; Karien Stronks; Maria Wany Strufaldi; Chien-An Sun; Johan Sundstroem; Yn-Tz Sung; Jordi Sunyer; Paibul Suriyawongpaisal; Boyd A. Swinburn; Rody G. Sy; Lucjan Szponar; E. Shyong Tai; Mari-Liis Tammesoo; Abdonas Tamosiunas; Line Tang; Xun Tang; Frank Tanser; Yong Tao; Mohammed Rasoul Tarawneh; Jakob Tarp; Carolina B. Tarqui-Mamani; Anne Taylor; Felicite Tchibindat; Holger Theobald; Lutgarde Thijs; Betina H. Thuesen; Anne Tjonneland; Hanna K. Tolonen; Janne S. Tolstrup; Murat Topbas; Roman Topor-Madry; Maties Torrent; Stefania Toselli; Pierre Traissac; Antonia Trichopoulou; Dimitrios Trichopoulos; Oanh T. H. Trinh; Atul Trivedi; Lechaba Tshepo; Marshall K. Tulloch-Reid; Tomi-Pekka Tuomainen; Jaakko Tuomilehto; Maria L. Turley; Per Tynelius; Themistoklis Tzotzas; Christophe Tzourio; Peter Ueda; Flora A. M. Ukoli; Hanno Ulmer; Belgin Unal; Hannu M. T. Uusitalo; Gonzalo Valdivia; Susana Vale; Damaskini Valvi; Yvonne T. van der Schouw; Koen Van Herck; Hoang Van Minh; Lenie van Rossem; Irene G. M. van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Lars Vatten; Tomas Vega; Gustavo Velasquez-Melendez; Giovanni Veronesi; W. M. Monique Verschuren; Roosmarijn Verstraeten; Cesar G. Victora; Giovanni Viegi; Lucie Viet; Eira Viikari-Juntura; Paolo Vineis; Jesus Vioque; Jyrki K. Virtanen; Sophie Visvikis-Siest; Bharathi Viswanathan; Peter Vollenweider; Sari Voutilainen; Ana Vrdoljak; Martine Vrijheid; Alisha N. Wade; Aline Wagner; Janette Walton; Wan Nazaimoon Wan Mohamud; Ming-Dong Wang; Qian Wang; Ya Xing Wang; S. Goya Wannamethee; Nicholas Wareham; Deepa Weerasekera; Peter H. Whincup; Kurt Widhalm; Indah S. Widyahening; Andrzej Wiecek; Alet H. Wijga; Rainford J. Wilks; Johann Willeit; Tom Wilsgaard; Bogdan Wojtyniak; Jyh Eiin Wong; Tien Yin Wong; Jean Woo; Mark Woodward; Frederick C. Wu; Jianfeng Wu; Shou Ling Wu; Haiquan Xu; Liang Xu; Uruwan Yamborisut; Weili Yan; Xiaoguang Yang; Nazan Yardim; Xingwang Ye; Panayiotis K. Yiallouros; Akihiro Yoshihara; Qi Sheng You; Novie O. Younger-Coleman; Ahmad F. Yusoff; Ahmad A. Zainuddin; Sabina Zambon; Tomasz Zdrojewski; Yi Zeng; Dong Zhao; Wenhua Zhao; Yingfeng Zheng; Maigeng Zhou; Dan Zhu; Esther Zimmermann; Julio Zuniga Cisneros
    ELIFE 5 2016年07月 [査読有り]
     
    Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
  • Fujita Y; Iki M
    Clinical calcium 26 7 1031 - 1037 2016年07月 [査読有り]
  • Yuki Fujita; Katsuyasu Kouda; Harunobu Nakamura; Masayuki Iki
    AMERICAN JOURNAL OF HUMAN BIOLOGY 28 3 330 - 334 2016年05月 [査読有り]
     
    Objectives: Few studies have reported on the association between changes in serum low-density lipoprotein cholesterol (LDL-C) and height increase. We investigated the association between LDL-C change and height increase during puberty in a 3-year follow-up study in Fukuroi City, Japan. Methods: The source population was all fifth grade 2,515 students enrolled in any public school in Fukuroi, Japan in 2008, 2009, and 2010. The follow-up survey was conducted in eighth grade students in 2011, 2012, and 2013. In total, 2,225 adolescents were followed. To evaluate the relationships between height increases and changes in LDL-C, a regression analysis was conducted after stratification by tertiles of weight change (LW: lowest group, MW: middle group, and HW: highest group). Results: In each weight change tertile, serum LDL-C significantly decreased from the lowest to highest tertiles of height change (LW: regression coefficient (B) = -0.12, MW: B = -0.07, HW: B = -0.08 in males; MW: B = -0.17, HW: B = -0.14 in females). The association between height increases and LDL-C was significantly stronger than that between weight increases and LDL-C (male: B = -0.609 and 95% CI -0.836 to -0.382 in height, B = 0.008 and 95% CI -0.193 to 0.209 in weight; female: B = -0.963 and 95% CI -1.301 to -0.624 in height, B = 0.366 and 95% CI 0.058-0.675 in weight). Conclusions: Serum LDL-C decreased with increasing height, independent of increases in weight. The association between LDL-C and height is stronger than that between LDL-C and weight. (C) 2015 Wiley Periodicals, Inc.
  • Eugene V. McCloskey; Anders Oden; Nicholas C. Harvey; William D. Leslie; Didier Hans; Helena Johansson; Reinhard Barkmann; Stephanie Boutroy; Jacques Brown; Roland Chapurlat; Petra J. M. Elders; Yuki Fujita; Claus-C Glueer; David Goltzman; Masayuki Iki; Magnus Karlsson; Andreas Kindmark; Mark Kotowicz; Norio Kurumatani; Timothy Kwok; Oliver Lamy; Jason Leung; Kurt Lippuner; Osten Ljunggren; Mattias Lorentzon; Dan Mellstroem; Thomas Merlijn; Ling Oei; Claes Ohlsson; Julie A. Pasco; Fernando Rivadeneira; Bjorn Rosengren; Elisabeth Sornay-Rendu; Pawel Szulc; Junko Tamaki; John A. Kanis
    JOURNAL OF BONE AND MINERAL RESEARCH 31 5 940 - 948 2016年05月 [査読有り]
     
    Trabecular bone score (TBS) is a gray-level textural index of bone microarchitecture derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images. TBS is a bone mineral density (BMD)-independent predictor of fracture risk. The objective of this meta-analysis was to determine whether TBS predicted fracture risk independently of FRAX probability and to examine their combined performance by adjusting the FRAX probability for TBS. We utilized individual-level data from 17,809 men and women in 14 prospective population-based cohorts. Baseline evaluation included TBS and the FRAX risk variables, and outcomes during follow-up (mean 6.7 years) comprised major osteoporotic fractures. The association between TBS, FRAX probabilities, and the risk of fracture was examined using an extension of the Poisson regression model in each cohort and for each sex and expressed as the gradient of risk (GR; hazard ratio per 1 SD change in risk variable in direction of increased risk). FRAX probabilities were adjusted for TBS using an adjustment factor derived from an independent cohort (the Manitoba Bone Density Cohort). Overall, the GR of TBS for major osteoporotic fracture was 1.44 (95% confidence interval [CI] 1.35-1.53) when adjusted for age and time since baseline and was similar in men and women (p > 0.10). When additionally adjusted for FRAX 10-year probability of major osteoporotic fracture, TBS remained a significant, independent predictor for fracture (GR = 1.32, 95% CI 1.24-1.41). The adjustment of FRAX probability for TBS resulted in a small increase in the GR (1.76, 95% CI 1.65-1.87 versus 1.70, 95% CI 1.60-1.81). A smaller change in GR for hip fracture was observed (FRAX hip fracture probability GR 2.25 vs. 2.22). TBS is a significant predictor of fracture risk independently of FRAX. The findings support the use of TBS as a potential adjustment for FRAX probability, though the impact of the adjustment remains to be determined in the context of clinical assessment guidelines. (C) 2015 American Society for Bone and Mineral Research.
  • Mariachiara Di Cesare; James Bentham; Gretchen A. Stevens; Bin Zhou; Goodarz Danaei; Yuan Lu; Honor Bixby; Melanie J. Cowan; Leanne M. Riley; Kaveh Hajifathalian; Lea Fortunato; Cristina Taddei; James E. Bennett; Nayu Ikeda; Young-Ho Khang; Catherine Kyobutungi; Avula Laxmaiah; Yanping Li; Hsien-Ho Lin; J. Jaime Miranda; Aya Mostafa; Maria L. Turley; Christopher J. Paciorek; Marc Gunter; Majid Ezzati; Ziad A. Abdeen; Zargar Abdul Hamid; Niveen M. Abu-Rmeileh; Benjamin Acosta-Cazares; Robert Adams; Wichai Aekplakorn; Carlos A. Aguilar-Salinas; Alireza Ahmadvand; Wolfgang Ahrens; Mohamed M. Ali; Ala'a Alkerwi; Mar Alvarez-Pedrerol; Eman Aly; Philippe Amouyel; Antoinette Amuzu; Lars Bo Andersen; Sigmund A. Anderssen; Dolores S. Andrade; Ranjit Mohan Anjana; Hajer Aounallah-Skhiri; Inger Ariansen; Tahir Aris; Nimmathota Arlappa; Dominique Arveiler; Felix K. Assah; Maria Avdicova; Fereidoun Azizi; Bontha V. Babu; Nagalla Balakrishna; Piotr Bandosz; Jose R. Banegas; Carlo M. Barbagallo; Alberto Barcelo; Amina Barkat; Mauro V. Barros; Iqbal Bata; Anwar M. Batieha; Rosangela L. Batista; Louise A. Baur; Robert Beaglehole; Habiba Ben Romdhane; Mikhail Benet; Antonio Bernabe-Ortiz; Gailute Bernotiene; Heloisa Bettiol; Aroor Bhagyalaxmi; Sumit Bharadwaj; Santosh K. Bhargava; Zaid Bhatti; Zulfiqar A. Bhutta; HongSheng Bi; Yufang Bi; Peter Bjerregaard; Espen Bjertness; Marius B. Bjertness; Cecilia Bjorkelund; Margaret Blake; Anneke Blokstra; Simona Bo; Martin Bobak; Lynne M. Boddy; Bernhard O. Boehm; Heiner Boeing; Carlos P. Boissonnet; Vanina Bongard; Pascal Bovet; Lutgart Braeckman; Marjolijn C. E. Bragt; Imperia Brajkovich; Francesco Branca; Juergen Breckenkamp; Hermann Brenner; Lizzy M. Brewster; Garry R. Brian; Graziella Bruno; H. B(as) Bueno-de-Mesquita; Anna Bugge; Con Burns; Antonio Cabrera de Leon; Joseph Cacciottolo; Tilema Cama; Christine Cameron; Jose Camolas; Gunay Can; Ana Paula C. Candido; Vincenzo Capuano; Viviane C. Cardoso; Maria J. Carvalho; Felipe F. Casanueva; Juan-Pablo Casas; Carmelo A. Caserta; Katia Castetbon; Snehalatha Chamukuttan; Angelique W. Chan; Queenie Chan; Himanshu K. Chaturvedi; Nishi Chaturvedi; Chien-Jen Chen; Fangfang Chen; Huashuai Chen; Shuohua Chen; Zhengming Chen; Ching-Yu Cheng; Angela Chetrit; Arnaud Chiolero; Shu-Ti Chiou; Adela Chirita-Emandi; Yumi Cho; Kaare Christensen; Jerzy Chudek; Renata Cifkova; Frank Claessens; Els Clays; Hans Concin; Cyrus Cooper; Rachel Cooper; Tara C. Coppinger; Simona Costanzo; Dominique Cottel; Chris Cowell; Cora L. Craig; Ana B. Crujeiras; Graziella D'Arrigo; Eleonora d'Orsi; Jean Dallongeville; Albertino Damasceno; Camilla T. Damsgaard; Goodarz Danaei; Rachel Dankner; Luc Dauchet; Guy De Backer; Dirk De Bacquer; Giovanni de Gaetano; Stefaan De Henauw; Delphine De Smedt; Mohan Deepa; Alexander D. Deev; Abbas Dehghan; Helene Delisle; Francis Delpeuch; Klodian Dhana; Augusto F. Di Castelnuovo; Juvenal Soares Dias-da-Costa; Alejandro Diaz; Shirin Djalalinia; Ha T. P. Do; Annette J. Dobson; Chiara Donfrancesco; Angela Doering; Kouamelan Doua; Wojciech Drygas; Eruke E. Egbagbe; Robert Eggertsen; Ulf Ekelund; Jalila El Ati; Paul Elliott; Reina Engle-Stone; Rajiv T. Erasmus; Cihangir Erem; Louise Eriksen; Jorge Escobedo-de la Pena; Alun Evans; David Faeh; Caroline H. Fall; Farshad Farzadfar; Francisco J. Felix-Redondo; Trevor S. Ferguson; Daniel Fernandez-Berges; Daniel Ferrante; Marika Ferrari; Catterina Ferreccio; Jean Ferrieres; Joseph D. Finn; Krista Fischer; Eric Monterubio Flores; Bernhard Foeger; Leng Huat Foo; Ann-Sofie Forslund; Stephen P. Fortmann; Heba M. Fouad; Damian K. Francis; Maria do Carmo Franco; Oscar H. Franco; Guillermo Frontera; Flavio D. Fuchs; Sandra C. Fuchs; Yuki Fujita; Takuro Furusawa; Zbigniew Gaciong; Mihai Gafencu; Dickman Gareta; Sarah P. Garnett; Jean-Michel Gaspoz; Magda Gasull; Louise Gates; Johanna M. Geleijnse; Anoosheh Ghasemian; Simona Giampaoli; Francesco Gianfagna; Jonathan Giovannelli; Aleksander Giwercman; Rebecca A. Goldsmith; Marcela Gonzalez Gross; Juan P. Gonzalez Rivas; Mariano Bonet Gorbea; Frederic Gottrand; Sidsel Graff -Iversen; Dusan Grafnetter; Aneta Grajda; Maria G. Grammatikopoulou; Ronald D. Gregor; Tomasz Grodzicki; Anders Grontved; Grabriella Gruden; Vera Grujic; Dongfeng Gu; Ong Peng Guan; Vilmundur Gudnason; Ramiro Guerrero; Idris Guessous; Andre L. Guimaraes; Martin C. Gulliford; Johanna Gunnlaugsdottir; Marc Gunter; Xiu H. Guo; Yin Guo; Prakash C. Gupta; Oye Gureje; Beata Gurzkowska; Laura Gutierrez; Felix Gutzwiller; Jytte Halkjaer; Rebecca Hardy; Rachakulla Hari Kumar; Alison J. Hayes; Jiang He; Marleen Elisabeth Hendriks; Leticia Hernandez Cadena; Ramin Heshmat; Ilpo Tapani Hihtaniemi; Sai Yin Ho; Suzanne C. Ho; Michael Hobbs; Albert Hofman; Claudia M. Hormiga; Bernardo L. Horta; Leila Houti; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; Yonghua Hu; Abdullatif S. Hussieni; Chinh Nguyen Huu; Inge Huybrechts; Nahla Hwalla; Licia Iacoviello; Anna G. Iannone; M. Mohsen Ibrahim; Nayu Ikeda; M. Arfan Ikram; Vilma E. Irazola; Muhammad Islam; Masanori Iwasaki; Rod T. Jackson; Jeremy M. Jacobs; Tazeen Jafar; Kazi M. Jamil; Konrad Jamrozik; Grazyna Jasienska; Chao Qiang Jiang; Michel Joffres; Mattias Johansson; Jost B. Jonas; Torben Jorgensen; Pradeep Joshi; Anne Juolevi; Gregor Jurak; Vesna Juresa; Rudolf Kaaks; Anthony Kafatos; Ofra Kalter-Leibovici; Efthymios Kapantais; Amir Kasaeian; Joanne Katz; Prabhdeep Kaur; Maryam Kavousi; Ulrich Keil; Lital Keinan Boker; Roya Kelishadi; Han H. C. G. Kemper; Andre P. Kengne; Mathilde Kersting; Timothy Key; Yousef Saleh Khader; Davood Khalili; Young-Ho Khang; Kay-Tee H. Khaw; Ilse M. S. L. Khouw; Stefan Kiechl; Japhet Killewo; Jeongseon Kim; Yutaka Kiyohara; Jeannette Klimont; Elin Kolle; Patrick Kolsteren; Paul Korrovits; Seppo Koskinen; Katsuyasu Kouda; Slawomir Koziel; Wolfgang Kratzer; Steinar Krokstad; Daan Kromhout; Herculina S. Kruger; Krzysztof Kula; Zbigniew Kulaga; R. Krishna Kumar; Yadlapalli S. Kusuma; Kari Kuulasmaa; Catherine Kyobutungi; Fatima Zahra Laamiri; Tiina Laatikainen; Carl Lachat; Youcef Laid; Tai Hing Lam; Orlando Landrove; Vera Lanska; Georg Lappas; Lars E. Laugsand; Avula Laxmaiah; Khanh Le Nguyen Bao; Tuyen D. Le; Catherine Leclercq; Jeannette Lee; Jeonghee Lee; Terho Lehtimaki; Rampal Lekhraj; Luz M. Leon-Munoz; Yanping Li; Wei-Yen Lim; M. Fernanda Lima-Costa; Hsien-Ho Lin; Xu Lin; Allan Linneberg; Lauren Lissner; Mieczyslaw Litwin; Jing Liu; Roberto Lorbeer; Paulo A. Lotufo; Jose Eugenio Lozano; Dalia Luksiene; Annamari Lundqvist; Nuno Lunet; Per Lytsy; Guansheng Ma; Suka Machi; Stefania Maggi; Dianna J. Magliano; Marcia Makdisse; Reza Malekzadeh; Rahul Malhotra; Kodavanti Mallikharjuna Rao; Yannis Manios; Jim I. Mann; Enzo Manzato; Paula Margozzini; Oonagh Markey; Pedro Marques-Vidal; Jaume Marrugat; Yves Martin-Prevel; Reynaldo Martorell; Shariq R. Masoodi; Tandi E. Matsha; Artur Mazur; Jean Claude N. Mbanya; Shelly R. McFarlane; Stephen T. McGarvey; Martin McKee; Stela McLachlan; Rachael M. McLean; Breige A. McNulty; Safiah Md Yusof; Sounnia Mediene-Benchekor; Aline Meirhaeghe; Christa Meisinger; Larissa L. Mendes; Ana Maria B. Menezes; Gert B. M. Mensink; Indrapal I. Meshram; Andres Metspalu; Jie Mi; Kim F. Michaelsen; Kairit Mikkel; Jody C. Miller; Juan Francisco Miquel; J. Jaime Miranda; Marjeta Misigoj-Durakovic; Mostafa K. Mohamed; Kazem Mohammad; Noushin Mohammadifard; Viswanathan Mohan; Muhammad Fadhli Mohd Yusoff; Drude Molbo; Niels C. Moller; Denes Molnar; Charles K. Mondo; Eric A. Monterrubio; Kotsedi Daniel K. Monyeki; Leila B. Moreira; Alain Morejon; Luis A. Moreno; Karen Morgan; Erik Lykke Mortensen; George Moschonis; Malgorzata Mossakowska; Aya Mostafa; Jorge Mota; Mohammad Esmaeel Motlagh; Jorge Motta; Thet Thet Mu; Maria Lorenza Muiesan; Martina Mueller-Nurasyid; Neil Murphy; Jaakko Mursu; Elaine M. Murtagh; Kamarul Imran Musa; Vera Musil; Gabriele Nagel; Harunobu Nakamura; Jana Namesna; Ei Ei K. Nang; Vinay B. Nangia; Martin Nankap; Sameer Narake; Eva Maria Navarrete-Munoz; Ilona Nenko; Martin Neovius; Flavio Nervi; Hannelore K. Neuhauser; Nguyen D. Nguyen; Quang Ngoc Nguyen; Ramfis E. Nieto-Martinez; Guang Ning; Toshiharu Ninomiya; Sania Nishtar; Marianna Noale; Teresa Norat; Davide Noto; Mohannad Al Nsour; Dermot O'Reilly; Angelica M. Ochoa-Aviles; Kyungwon Oh; Iman H. Olayan; Maria Teresa Anselmo Olinto; Maciej Oltarzewski; Mohd A. Omar; Altan Onat; Pedro Ordunez; Ana P. Ortiz; Merete Osler; Clive Osmond; Sergej M. Ostojic; Johanna A. Otero; Kim Overvad; Fred Michel Paccaud; Cristina Padez; Andrzej Pajak; Domenico Palli; Alberto Palloni; Luigi Palmieri; Songhomitra Panda-Jonas; Francesco Panza; Winsome R. Parnell; Mahboubeh Parsaeian; Mangesh S. Pednekar; Petra H. Peeters; Sergio Viana Peixoto; Alexandre C. Pereira; Cynthia M. Perez; Annette Peters; Niloofar Peykari; Son Thai Pham; Iris Pigeot; Hynek Pikhart; Aida Pilav; Lorenza Pilotto; Francesco Pistelli; Freda Pitakaka; Aleksandra Piwonska; Jerzy Piwonski; Pedro Plans-Rubio; Bee Koon Poh; Miquel Porta; Marileen L. P. Portegies; Dimitrios Poulimeneas; Rajendra Pradeepa; Mathur Prashant; Jacqueline F. Price; Maria Puiu; Margus Punab; Radwan F. Qasrawi; Mostafa Qorbani; Tran Quoc Bao; Ivana Radic; Ricardas Radisauskas; Mahmudur Rahman; Olli Raitakari; Manu Raj; Sudha Ramachandra Rao; Ambady Ramachandran; Jacqueline Ramke; Rafel Ramos; Sanjay Rampal; Finn Rasmussen; Josep Redon; Paul Ferdinand M. Reganit; Robespierre Ribeiro; Elio Riboli; Fernando Rigo; Tobias Floris Rinke de Wit; Raphael M. Ritti-Dias; Juan A. Rivera; Sian M. Robinson; Cynthia Robitaille; Fernando Rodriguez-Artalejo; Maria del Cristo Rodriguez-Perez; Laura A. Rodriguez-Villamizar; Rosalba Rojas-Martinez; Nipa Rojroongwasinkul; Dora Romaguera; Kimmo Ronkainen; Annika Rosengren; Ian Rouse; Adolfo Rubinstein; Frank J. Ruehli; Ornelas Rui; Blanca Sandra Ruiz-Betancourt; Andrea R. V. Russo Horimoto; Marcin Rutkowski; Charumathi Sabanayagam; Harshpal S. Sachdev; Olfa Saidi; Benoit Salanave; Eduardo Salazar Martinez; Veikko Salomaa; Jukka T. Salonen; Massimo Salvetti; Jose Sanchez-Abanto; Sandjaja; Susana Sans; Diana A. Santos; Osvaldo Santos; Renata Nunes dos Santos; Rute Santos; Luis B. Sardinha; Nizal Sarrafzadegan; Kai-Uwe Saum; Savvas C. Savva; Marcia Scazufca; Angelika Schaffrath Rosario; Herman Schargrodsky; Anja Schienkiewitz; Ida Maria Schmidt; Ione J. Schneider; Constance Schultsz; Aletta E. Schutte; Aye Aye Sein; Idowu O. Senbanjo; Sadaf G. Sepanlou; Svetlana A. Shalnova; Jonathan E. Shaw; Kenji Shibuya; Youchan Shin; Rahman Shiri; Rosalynn Siantar; Abla M. Sibai; Antonio M. Silva; Diego Augusto Santos Silva; Mary Simon; Judith Simons; Leon A. Simons; Michael Sjostrom; Jolanta Slowikowska-Hilczer; Przemyslaw Slusarczyk; Liam Smeeth; Margaret C. Smith; Marieke B. Snijder; Hung-Kwan So; Eugene Sobngwi; Stefan Soderberg; Moesijanti Y. E. Soekatri; Vincenzo Solfrizzi; Emily Sonestedt; Thorkild I. A. Sorensen; Maroje Soric; Charles Sossa Jerome; Aicha Soumare; Jan A. Staessen; Gregor Starc; Maria G. Stathopoulou; Kaspar Staub; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D. Stein; George S. Stergiou; Jochanan Stessman; Jutta Stieber; Doris Stoeckl; Tanja Stocks; Jakub Stokwiszewski; Gareth Stratton; Maria Wany Strufaldi; Chien-An Sun; Johan Sundstrom; Yn-Tz Sung; Jordi Sunyer; Paibul Suriyawongpaisal; Boyd A. Swinburn; Rody G. Sy; Lucjan Szponar; E. Shyong Tai; Mari-Liis Tammesoo; Abdonas Tamosiunas; Line Tang; Xun Tang; Frank Tanser; Yong Tao; Jakob Tarp; Carolina B. Tarqui-Mamani; Anne Taylor; Felicite Tchibindat; Lutgarde Thijs; Betina H. Thuesen; Anne Tjonneland; Hanna K. Tolonen; Janne S. Tolstrup; Murat Topbas; Roman Topor-Madry; Maties Torrent; Pierre Traissac; Antonia Trichopoulou; Dimitrios Trichopoulos; Oanh T. H. Trinh; Atul Trivedi; Lechaba Tshepo; Marshall K. Tulloch-Reid; Tomi-Pekka Tuomainen; Jaakko Tuomilehto; Maria L. Turley; Per Tynelius; Themistoklis Tzotzas; Christophe Tzourio; Peter Ueda; Flora A. M. Ukoli; Hanno Ulmer; Belgin Unal; Gonzalo Valdivia; Susana Vale; Damaskini Valvi; Yvonne T. van der Schouw; Koen Van Herck; Hoang Van Minh; Irene G. M. van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Lars Vatten; Tomas Vega; Gustavo Velasquez-Melendez; Giovanni Veronesi; W. M. Monique Verschuren; Giovanni Viegi; Lucie Viet; Eira Viikari-Juntura; Paolo Vineis; Jesus Vioque; Jyrki K. Virtanen; Sophie Visvikis-Siest; Bharathi Viswanathan; Peter Vollenweider; Sari Voutilainen; Martine Vrijheid; Alisha N. Wade; Aline Wagner; Janette Walton; Wan Nazaimoon Wan Mohamud; Ming-Dong Wang; Qian Wang; Ya Xing Wang; S. Goya Wannamethee; Nicholas Wareham; Deepa Weerasekera; Peter H. Whincup; Kurt Widhalm; Indah S. Widyahening; Andrzej Wiecek; Rainford J. Wilks; Johann Willeit; Bogdan Wojtyniak; Jyh Eiin Wong; Tien Yin Wong; Jean Woo; Mark Woodward; Frederick C. Wu; JianFeng Wu; Shou Ling Wu; Haiquan Xu; Liang Xu; Uruwan Yamborisut; Weili Yan; Xiaoguang Yang; Nazan Yardim; Xingwang Ye; Panayiotis K. Yiallouros; Akihiro Yoshihara; Qi Sheng You; Novie O. Younger-Coleman; Ahmad F. Yusoff; Ahmad A. Zainuddin; Sabina Zambon; Tomasz Zdrojewski; Yi Zeng; Dong Zhao; Wenhua Zhao; Yingfeng Zheng; Maigeng Zhou; Dan Zhu; Esther Zimmermann; Julio Zuniga Cisneros
    LANCET 387 10026 1377 - 1396 2016年04月 [査読有り]
     
    Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (<18.5 kg/m(2) [underweight], 18.5 kg/m(2) to <20 kg/m(2), 20 kg/m(2) to <25 kg/m(2), 25 kg/m(2) to <30 kg/m(2), 30 kg/m(2) to <35 kg/m(2), 35 kg/m(2) to <40 kg/m(2), = 40 kg/m(2) [morbid obesity]), by sex in 200 countries and territories, organised in 21 regions. We calculated the posterior probability of meeting the target of halting by 2025 the rise in obesity at its 2010 levels, if post-2000 trends continue. Findings We used 1698 population-based data sources, with more than 19.2 million adult participants (9.9 million men and 9.3 million women) in 186 of 200 countries for which estimates were made. Global age-standardised mean BMI increased from 21.7 kg/m(2) (95% credible interval 21.3-22.1) in 1975 to 24.2 kg/m(2) (24.0-24.4) in 2014 in men, and from 22.1 kg/m(2) (21.7-22.5) in 1975 to 24.4 kg/m(2) (24.2-24.6) in 2014 in women. Regional mean BMIs in 2014 for men ranged from 21.4 kg/m(2) in central Africa and south Asia to 29.2 kg/m(2) (28.6-29.8) in Polynesia and Micronesia; for women the range was from 21.8 kg/m(2) (21.4-22.3) in south Asia to 32.2 kg/m(2) (31.5-32.8) in Polynesia and Micronesia. Over these four decades, age-standardised global prevalence of underweight decreased from 13.8% (10.5-17.4) to 8.8% (7.4-10.3) in men and from 14.6% (11.6-17.9) to 9.7% (8.3-11.1) in women. South Asia had the highest prevalence of underweight in 2014, 23.4% (17.8-29.2) in men and 24.0% (18.9-29.3) in women. Age-standardised prevalence of obesity increased from 3.2% (2.4-4.1) in 1975 to 10.8% (9.7-12.0) in 2014 in men, and from 6.4% (5.1-7.8) to 14.9% (13.6-16.1) in women. 2.3% (2.0-2.7) of the world's men and 5.0% (4.4-5.6) of women were severely obese (ie, have BMI = 35 kg/m(2)). Globally, prevalence of morbid obesity was 0.64% (0.46-0.86) in men and 1.6% (1.3-1.9) in women. Interpretation If post-2000 trends continue, the probability of meeting the global obesity target is virtually zero. Rather, if these trends continue, by 2025, global obesity prevalence will reach 18% in men and surpass 21% in women; severe obesity will surpass 6% in men and 9% in women. Nonetheless, underweight remains prevalent in the world's poorest regions, especially in south Asia. Copyright (C) NCD Risk Factor Collaboration. Open Access article distributed under the terms of CC BY.
  • 小・中学生における食行動・食態度と体組成との関連について
    小原 久未子; 甲田 勝康; 間瀬 知紀; 藤田 裕規; 宮脇 千惠美; 桃井 克将; 村山 留美子; 中村 晴信
    日本公衆衛生学会総会抄録集 74回 318 - 318 日本公衆衛生学会 2015年10月 [査読有り]
  • 中学生における体組成と生活習慣やダイエット経験との関連
    中村 晴信; 小原 久未子; 甲田 勝康; 藤田 裕規; 間瀬 知紀; 宮脇 千惠美; 桃井 克将; 村山 留美子
    日本公衆衛生学会総会抄録集 74回 318 - 318 日本公衆衛生学会 2015年10月 [査読有り]
  • Iki M; Fujita Y; Tamaki J; Kouda K; Yura A; Sato Y; Moon JS; Winzenrieth R; Okamoto N; Kurumatani N
    Osteoporos Int 26 6 1841 - 1848 2015年06月 [査読有り]
     
    ASummary FRAXA (R) is widely used to evaluate fracture risk of individuals in clinical settings. However, FRAXA (R) prediction accuracy is not sufficient, and improvement is desired. Trabecular bone score, a bone microarchitecture index, may improve FRAXA (R) prediction accuracy for major osteoporotic fractures in community-dwelling elderly Japanese men. Introduction To improve fracture risk assessment in clinical settings, we evaluated whether the combination of FRAXA (R) and Trabecular Bone Score (TBS) improves the prediction accuracy of major osteoporotic fractures (MOFs) in elderly Japanese men compared to FRAXA (R) alone. Methods Two thousand and twelve community-dwelling men aged a parts per thousand yen65 years completed the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Baseline Study comprising lumbar spine (LS) and femoral neck areal bone mineral density (aBMD) measurements, and interviews regarding clinical risk factors required to estimate 10-year risk of MOF (hip, spine, distal forearm, and proximal humerus) using the Japanese version of FRAXA (R) (v.3.8). TBS was calculated for the same vertebrae used for LS-aBMD with TBS iNsight software (v.2.1). MOFs that occurred during the follow-up period were identified by interviews or mail and telephone surveys. Prediction accuracy of a logistic model combining FRAXA (R) score and TBS compared to FRAXA (R) alone was evaluated by area under receiver-operating characteristic curves (AUCs), as well as category-free integrated discrimination improvement (IDI) and net reclassification improvement (NRI). Results We identified 22 men with MOFs during 8140 person-years (PY) of follow-up among 1872 men; 67 men who suffered from fractures other than MOFs were excluded. Participants with MOFs had significantly lower TBS (p = 0.0015) and higher FRAXA (R) scores (p = 0.0089) than those without. IDI and NRI showed significant improvements in reclassification accuracy using FRAXA (R) plus TBS compared to FRAXA (R) alone (IDI 0.006 (p = 0.0362), NRI 0.452 (p = 0.0351)), although no difference was observed in AUCs between the two. Conclusions TBS may improve MOF prediction accuracy of FRAXA (R) for community-dwelling elderly Japanese men.
  • Y. Sato; M. Iki; Y. Fujita; J. Tamaki; K. Kouda; A. Yura; J. -S. Moon; R. Winzenrieth; H. Iwaki; R. Ishizuka; N. Amano; K. Tomioka; N. Okamoto; N. Kurumatani
    OSTEOPOROSIS INTERNATIONAL 26 5 1585 - 1594 2015年05月 [査読有り]
     
    A Summary The effects of milk intake on bone health are not clear in elderly Asian men with low dietary calcium intake. This study showed that greater milk intake is associated with lower bone turnover, higher bone density, and higher bone microarchitecture index in community-dwelling elderly Japanese men. Introduction The consumption of milk or dairy products is widely recommended for maintaining bone health regardless of gender or age. However, little evidence exists on the beneficial effects of milk intake on bone health in elderly Japanese men characterized with relatively low dietary calcium intake. Here we examined whether or not greater milk intake was associated with lower bone turnover, higher bone density, and stronger bone microarchitecture in community-dwelling elderly Japanese men. Methods Interviews were conducted to obtain information on medical history and lifestyle, including the amount of habitual milk intake, nutrient intake calculations based on a 1-week food diary, and measurements of areal bone mineral density (aBMD) at the lumbar spine (LS), total hip (TH), and femoral neck (FN) by dual-energy x-ray absorptiometry (DXA), trabecular bone score (TBS) using DXA images at LS, and biochemical markers of bone turnover in sera. Participants with a history of diseases or medications that affect bone metabolism, or with missing data, were excluded from the analysis. Results The median intake of milk in the 1479 participants (mean age, 73.0 +/- 5.1 years) was one glass of milk per day. Bone turnover markers showed a decreasing trend (p < 0.05) and aBMD at TH (p = 0.0019) and FN (p = 0.0057) and TBS (p = 0.0017) showed increasing trends with greater milk intake after adjusting for demographic and behavioral confounding factors. This association was attenuated after further adjusting for nutrient intake, in particular, calcium intake. Conclusions Greater milk intake was associated with lower bone turnover, higher aBMD, and higher TBS in community-dwelling elderly Japanese men.
  • Katsuyasu Kouda; Harunobu Nakamura; Yuki Fujita; Masami Hamada; Etsuko Kajita; Yoshimi Nakatani; Yuho Sato; Kazuhiro Uenishi; Masayuki Iki
    CLINICA CHIMICA ACTA 444 101 - 105 2015年04月 [査読有り]
     
    Background: Obesity, defined as the excessive accumulation of body fat, is frequently associated with low concentrations of high-density lipoprotein (HDL) cholesterol. However, HDL particles are heterogeneous in size and composition. HDL subclasses may be differentially associated with body fat. Methods: This study investigated associations between the cholesterol concentrations of HDL subclasses, as determined by high-performance liquid chromatography, and body fat variables, as measured by dual-energy X-ray absorptiometry. The source population was all ninth grade students who attended Shiokawa Junior High School in Japan. Results: Cross-sectional data on body fat and serum HDL subclasses were obtained for 87 students (72.5% of the source population). The cholesterol concentration of the large HDL subclass showed a significant (P < 0.05) inverse relationship with whole body fat and trunk fat (r = -0.24 and -0.30), whereas the concentration of the small HDL subclass showed a significant positive relationship with these body fat variables (r = 0.25 and 0.31). After adjusting for potential confounding factors, the mean concentration of small HDL significantly increased from the lowest to highest tertiles of trunk fat mass index. Conclusion: These results indicate that HDL subclasses are heterogeneous in their associations with body fat variables that were accurately measured by dual-energy X-ray absorptiometry among Japanese students. (C) 2015 Elsevier B.V. All rights reserved.
  • Kumiko Ohara; Yoshiko Kato; Tomoki Mase; Katsuyasu Kouda; Chiemi Miyawaki; Yuki Fujita; Yoshimitsu Okita; Harunobu Nakamura
    EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY 19 4 461 - 468 2014年12月 [査読有り]
     
    Purpose We investigated the relationship between eating behavior measured by the Dutch Eating Behaviour Questionnaire (DEBQ) and perception of body shape, examining the current physical status and 'ideal' physical parameters in females and males. Methods The participants, 548 Japanese university students (age 19.2 +/- A 0.9 years, mean +/- A SD; 252 males, 296 females), completed a questionnaire which asked for their current physical status (e.g., weight and height), their ideal physical parameters, their perception of their current body shape, their ideal body shape, and their eating behaviors. Results The ideal weight and ideal body mass index (BMI) were significantly higher than the current weight and BMI in the males, but significantly lower in the females. Among the females, the ideal body shape was smaller than their perception of current body shape. The DEBQ scores for restrained, emotional, and external eating were higher in the females than the males among the normal-weight participants, and among the underweight participants, the restrained eating and external eating scores were higher in the females than the males. Restrained eating was negatively associated with the discrepancy between the current and ideal weight, BMI, and body shape in both the males and females. Emotional eating was negatively associated with the discrepancy in current/ideal BMI and body shape only in the females. Conclusions At least in Japanese university students, the gender differences in ideal body shape are related to eating behavior.
  • Katsuyasu Kouda; Yuki Fujita; Yuho Sato; Kumiko Ohara; Harunobu Nakamura; Kazuhiro Uenishi; Masayuki Iki
    BONE 64 298 - 302 2014年07月 [査読有り]
     
    Epidemiologic studies have found that higher body weight is associated with better bone health. Body weight consists of both fat mass (FM) and lean soft tissue mass (LSTM). Previous studies have examined the effects of FM levels during childhood on bone health, with conflicting results. In the present study, we investigated the independent contributions of FM to bone mass in Japanese adolescents. Subjects were 235 adolescents aged 15-18 years old in August 2010 and in August 2013 from the Kitakata Kids Health Study in Japan. We obtained cross-sectional data on body composition as well as bone mineral density (BMD). Body composition and BMD were measured using a dual-energy X-ray absorptiometry scanner. We found moderate and positive relationships between FM index and LSTM index (males, r = 0.69; females, r = 0.44). To verify a potentially additive effect of FM on the variance of bone variables beyond LSTM, we assessed the association between FM index and bone variables after stratification by tertiles of the LSTM index. In the lowest tertile of the LSTM index, FM index was significantly (P < 0.05) associated with both femoral neck BMD (males, beta = 0.48; females, beta = 033) and whole body BMC (males, beta = 0.41; females, beta = 0.25). On the other hand, we found no significant associations between FM index and bone variables in other tertiles of the LSTM index. These findings indicate that FM can influence how high bone mass is obtained among relatively thin adolescents, but not among those who are of normal weight or overweight. (C) 2014 Elsevier Inc. All rights reserved.
  • Yuki Fujita; Katsuyasu Kouda; Harunobu Nakamura; Nobuhiro Nishio; Hiroichi Takeuchi; Masayuki Iki
    ANNALS OF HUMAN BIOLOGY 41 1 91 - 93 2014年01月 [査読有り]
     
    Context: Although there is a positive relationship between height and blood pressure (BP) levels in children, there are no reports regarding the association between height and BP levels in adolescents and adults. Objective: This study examined whether there is an association between height and BP levels in Japanese adolescents. Methods: The source population was all fifth (10 and 11-year-olds) and ninth graders (14 and 15-year-olds) who attended 11 elementary schools and five junior high schools in the Iwata area from 2002-2008. School-based screenings were conducted annually by the local government from April to June. Data obtained from health examinations were analysed, including anthropometric measurements and BP levels, for 11 780 children (98.7% of the source population). Results: Height showed significant positive relationships with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in childhood and in adolescent males. In contrast, the relationship between height and SBP was significantly weaker in adolescent females than in childhood and there was no significant relationship between height and DBP in adolescent females. Conclusion: The relationship between height and SBP was attenuated by development in females and the relationship between height and DBP disappeared.
  • Katsuyasu Kouda; Harunobu Nakamura; Yuki Fujita; Kumiko Ohara; Masayuki Iki
    NUTRITION 29 10 1204 - 1208 2013年10月 [査読有り]
     
    Objective: For a general population of children, data on the relationship between vitamin D status and adiposity are limited. The aim of this study was to assess the relationships between the serum concentration of 25-hydroxyvitamin D (25-OH-D) and body fat variables measured by dual-energy X-ray absorptiometry (DXA) in a general population of Japanese children, including underweight, normal, and overweight children. Methods: The source population comprised 521 fifth-grade children who attended either of the two public schools in Hamamatsu, Japan. Total and regional body fat mass (FM) measured by DXA were evaluated along with the serum concentration of 25-OH-D. Results: We were able to analyze the FM and 25-OH-D data of 400 of the 521 children. Among boys, significant inverse relationships were observed between serum vitamin D levels and body fat variables (total FM, r = -0.201; trunk FM, r = -0.216; appendicular FM, r = -0.187; P < 0.05 for all values). Mean values of total FM and trunk FM in the vitamin D-deficient group (25-OH-D <50 nmol/L) were larger than those in the vitamin D-sufficient group (25-OH-D >= 75 nmol/L) after adjusting for confounding factors, such as sedentary behavior (P < 0.05). No relationship was observed between vitamin D status and FM among girls. Conclusions: Vitamin D deficiency was associated with higher total and trunk adiposities in a general population of Japanese children, particularly boys. (c) 2013 Elsevier Inc. All rights reserved.
  • 藤田 裕規; 伊木 雅之; 甲田 勝康; 由良 晶子; Junko Tamaki; Eiko Kadowaki; Yuho Sato; Jong-Seong Moon; Kimiko Tomioka; Nozomi Okamoto; Norio Kurumatani
    Bone 56 1 61 - 66 2013年10月
  • Yuki Fujita; Masayuki Iki; Junko Tamaki; Katsuyasu Kouda; Akiko Yura; Eiko Kadowaki; Yuho Sato; Jong-Seong Moon; Kimiko Tomioka; Nozomi Okamoto; Norio Kurumatani
    Bone 56 1 61 - 66 2013年09月 [査読有り]
     
    End-stage renal failure deteriorates bone mass and increases fracture risk. However, there are conflicting reports in the literature regarding the effects of mild to moderate renal dysfunction on bone mineral density (BMD). We investigated the association between renal function and BMD at the spine and hip and bone metabolism markers in community-dwelling elderly Japanese men. From 2174 male volunteers aged ≥. 65. years, we examined 1477 men after excluding those with diseases or medications known to affect bone metabolism. Renal function was assessed by serum cystatin C and estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease Study equation. Bone metabolism was evaluated using levels of serum amino-terminal propeptide of type I procollagen (PINP) and tartrate-resistant acid phosphatase isoenzyme 5b (TRACP-5b), which represent bone metabolic status independent of renal function. eGFR was inversely associated with BMD after adjusting for potential confounders (P. < . 0.01). Cystatin C showed a weaker but significant association with BMD. eGFR was modestly positively associated with PINP levels (P. = 0.04), although cystatin C concentrations were neither associated with PINP nor TRACP-5b levels. Since BMD integrates bone metabolism from the past to present, inverse associations between renal function and BMD may be attributed to past factors, such as obesity. Our findings suggest that low renal function does not affect bone metabolism in a population of community-dwelling elderly Japanese men. Longitudinal studies will be necessary to clarify whether low renal function affects bone loss. © 2013 Elsevier Inc.
  • Tomoki Mase; Chiemi Miyawaki; Katsuyasu Kouda; Yuki Fujita; Kumiko Ohara; Harunobu Nakamura
    EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY 18 2 125 - 132 2013年06月 
    Objective We conducted a questionnaire survey among Japanese female students to explore the influence of a desire for thinness and dietary behaviors on the development of eating disorders. Methods Self-reported measures of socio-demographic characteristics, body weight perception, height and weight, and dietary and exercise behavior were completed by 631 female university students at 6 universities in Kyoto, Japan. Results Many students had a desire for thinness (underweight students, 51.7 %; normal-weight students, 88.8 %), whereas ideal weight and body mass index were lower in the students with a desire for thinness than the students without a desire for thinness, and were also lower in the underweight students than the normal-weight students. The eating attitude test (EAT-26) scores of underweight students with a desire for thinness were higher than those of the normal-weight students with a desire for thinness. As a result of a logistic regression analysis, underweight, desire for thinness, and experience with weight control were positively associated with eating problems. Further, the association of eating problems increased along with the increase in the number of factors (underweight, desire for thinness, and experience with weight control). Conclusions These results indicate that underweight females have strong associations with eating problems.
  • Tomoki Mase; Chiemi Miyawaki; Katsuyasu Kouda; Yuki Fujita; Kumiko Ohara; Harunobu Nakamura
    EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY 18 2 125 - 132 2013年06月 [査読有り]
     
    Objective We conducted a questionnaire survey among Japanese female students to explore the influence of a desire for thinness and dietary behaviors on the development of eating disorders. Methods Self-reported measures of socio-demographic characteristics, body weight perception, height and weight, and dietary and exercise behavior were completed by 631 female university students at 6 universities in Kyoto, Japan. Results Many students had a desire for thinness (underweight students, 51.7 %; normal-weight students, 88.8 %), whereas ideal weight and body mass index were lower in the students with a desire for thinness than the students without a desire for thinness, and were also lower in the underweight students than the normal-weight students. The eating attitude test (EAT-26) scores of underweight students with a desire for thinness were higher than those of the normal-weight students with a desire for thinness. As a result of a logistic regression analysis, underweight, desire for thinness, and experience with weight control were positively associated with eating problems. Further, the association of eating problems increased along with the increase in the number of factors (underweight, desire for thinness, and experience with weight control). Conclusions These results indicate that underweight females have strong associations with eating problems.
  • Yuki Fujita; Katsuyasu Kouda; Harunobu Nakamura; Masayuki Iki
    JOURNAL OF EPIDEMIOLOGY 23 2 103 - 108 2013年03月 [査読有り]
     
    Background: Because of the lack of relevant data, we investigated the association between rapid weight gain (RWG) during early childhood and cardiovascular risk factors in Japanese adolescents. Methods: The source population comprised 2285 adolescents aged 13 to 14 years enrolled in any public school in Fukuroi City, Japan during 2008, 2009, or 2010. Since there are no private schools in this city, almost all adolescents who lived in the city went to 1 of these schools. We obtained data on blood pressure (BP), serum lipids, and anthropometry during adolescence, as well as anthropometry at birth, age 1.5 years, and age 3 years, from the Maternal and Child Health Handbook for 1624 children. RWG was defined as a change in body-weight standard deviation score greater than 0.67 from age 0 to 1.5 years or from age 1.5 to 3 years. Results: After adjusting for confounding factors, adolescents who had RWG from 0 to age 1.5 years or from age 1.5 to 3 years were more likely to be overweight. Adolescents who had RWG during both periods were more likely to be overweight (odds ratio [OR], 6.37; 95% CI, 3.06-13.24), have unfavorable lipid concentrations (OR, 2.03; 95% CI, 1.15-3.58), and have high BP (OR: 2.36, 95% CI: 1.34-4.13). The associations with unfavorable lipid concentrations and high BP disappeared after further adjusting for current body mass index. Conclusions: RWG during early childhood predicts unfavorable lipid concentrations and high BP in Japanese adolescents, and this relationship is mediated by body mass index in later life.
  • Katsuyasu Kouda; Harunobu Nakamura; Yuki Fujita; Kumiko Ohara; Masayuki Iki
    CIRCULATION JOURNAL 76 12 2848 - 2854 2012年12月 [査読有り]
     
    Background: Body fat distribution is defined as the pattern of fat deposits in different regions of the body and usually expressed as a ratio. There are few studies on the relationship between blood pressure and the ratio of central fat measured on dual-energy X-ray absorptiometry (DXA) in childhood. Methods and Results: The source population consisted of 521 fifth-grade children who attended elementary school in Hamamatsu, Japan, with 401 (77.0%) included in the study. Regional fat was determined using a DXA scanner in a mobile test room. The ratio of trunk to appendicular fat was calculated as trunk fat mass divided by appendicular (arms and legs) fat mass. In boys, the trunk-to-appendicular fat ratio was significantly related to systolic blood pressure and diastolic blood pressure after adjusting for confounding factors such as height and pubic hair appearance. In addition, an increase in trunk-to-appendicular fat ratio was related to an increase in blood pressure after adjusting for confounding factors including whole body fat volume and trunk fat volume. The relationship between fat distribution and blood pressure was not observed in girls. Conclusions: An excessive proportion of trunk fat was related to increased blood pressure in the boys in a general population of Japanese children. The relationship between fat distribution and blood pressure was independent of the relationship between fat volume and blood pressure. (Circ J 2012; 76: 2848-2854)
  • 中村 晴信; 沖田 善光; 甲田 勝康; 藤田 裕規; 西尾 信宏; 間瀬 知紀; 宮脇 千惠美; 桑原 恵介; 小原 久未子
    小児保健研究 71 5 698 - 708 (公社)日本小児保健協会 2012年09月 
    本研究においては、中学生を対象として、ゲームやテレビの使用状況と、生活習慣や精神・身体症状、および保護者の把握状況との関連について検討した。兵庫県A市内の全中学校の中学1年生、2年生、3年生計1,165名とその保護者を対象に、ゲーム・テレビの使用時間、生活習慣、精神・身体症状に関する質問紙調査を行った。その結果、ゲームやテレビの使用時間と生活習慣や精神・身体症状との間に関連性がみられた。また、ゲームやテレビの使用時間や精神・身体症状について保護者と子どもとの間での回答の一致性は低く、ゲームの使用時間が長い場合や精神・身体症状がある場合に回答が不一致である割合が高かった。以上より、情報機器の使用に関しては、本人だけでなく、保護者の把握状況も関連している可能性もあり、今後の詳細な検討が必要である。(著者抄録)
  • Katsuyasu Kouda; Harunobu Nakamura; Yuki Fujita; Masayuki Iki
    JOURNAL OF EPIDEMIOLOGY 22 5 411 - 416 2012年09月 [査読有り]
     
    Background: A few studies reported an association between body weight during early childhood and body composition in later life, as measured by dual-energy X-ray absorptiometry (DXA); however, none of those studies investigated an East Asian population. In a Japanese population, we examined the association between body weight at age 3 years and body composition at age 11 years, as measured using DXA. Methods: The source population was 726 fifth-grade school children enrolled at 3 public schools in Shizuoka Prefecture, Japan from 2008-2010. All children who lived in the study area went to 1 of these 3 schools. DXA was used to obtain data on body composition, and the Maternal and Child Health Handbook was used to calculate body mass index (BMI). The general linear model was used for statistical analysis. Results: We were able to analyze data on body composition at age 11 years and BMI in early childhood for 550 children. BMI at age 3 and change in BMI z-score from birth to age 3 were positively associated with bone mineral content (BMC), fat-free soft tissue mass (FFSTM), and fat mass (FM) at age 11. After adjusting for confounding factors, mean BMC, FFSTM, and FM were significantly lower among children who were underweight at age 3 and significantly higher among children who were overweight at age 3, as compared with values for normal-weight children at age 3. Conclusions: Among Japanese children, body weight at age 3 years predicts body composition at age 11 years.
  • Akira Minematsu; Kan Hazaki; Akihiro Harano; Masayuki Iki; Yuki Fujita; Nozomi Okamoto; Norio Kurumatani
    JOURNAL OF CLINICAL DENSITOMETRY 15 3 343 - 350 2012年07月 [査読有り]
     
    Screening for low bone mass is important to prevent fragility fractures in men as well as women, although men show a much lower prevalence of osteoporosis than women. The purpose of this study was to establish a screening model for low bone mineral density (BMD) using a quantitative ultrasound parameter and easily obtained objective indices for elderly Japanese men. We examined 1633 men (65-84 yr old) who were subjects of the Fujiwara-Kyo Study. Speed of sound (SOS) at the calcaneus was determined, and BMD was measured by dual-energy X-ray absorptiometry at the lumbar spine (LS), total hip (TH), and femoral neck (FN). Low BMD was defined as > 1 standard deviation below the young adult mean, in accordance with World Health Organization criteria. We performed receiver operating characteristic (ROC) analysis to identify a better screening model incorporating SOS and determined the optimal cutoff value using Youden index. Prevalences of low BMD at the 3 skeletal sites were 27.8% (LS), 33.5% (TH), 48.6% (FN), and 43.3% at either LS or TH. The greatest area under the ROC curve (0.806, 95% confidence interval: 0.785-0.828) and smallest Akaike's information criterion were obtained in the multivariate model incorporating SOS, age, height, and weight for predicting low BMD at all skeletal sites. This model predicted low BMD at TH with the sensitivity of 0.726 and specificity of 0.739, whereas a similar model predicted low BMD at LS with much lower validity. We conclude that the multivariate model for TH could be used to screen for low BMD in elderly Japanese men.
  • 間瀬 知紀; 宮脇 千惠美; 甲田 勝康; 藤田 裕規; 沖田 善光; 小原 久未子; 見正 富美子; 中村 晴信
    日本公衆衛生雑誌 59 6 371 - 380 日本公衆衛生学会 2012年06月 
    目的 本研究は、女子学生を対象として、若年女性における正常体重肥満者、いわゆる「隠れ肥満」の体組成に影響を及ぼすと考えられる食行動、運動習慣および身体活動量について検討した。方法 対象は京都府内の大学6校に在籍する18〜21歳の女子学生530人である。体脂肪率、歩数の測定および無記名自記式の質問紙調査を2010年1月〜2010年7月にかけて実施した。質問紙調査項目は生活環境、体型認識、体型への希望、ダイエット経験、運動習慣、睡眠時間および食行動に関する7項目であった。食行動調査はEAT-26(Eating Attitude Test 26:摂食態度調査票)を実施した。BMIが18.5以上25.0未満の「標準体重(n=439)」判定者の中で、体脂肪率が75%タイル以上の者を「High group(n=115)」、体脂肪率が25%タイル以下の者を「Low group(n=111)」、この2群以外の者を「Middle group(n=213)」と分類し、3群について比較検討した。結果 質問紙調査より、グループ間に体型認識、体型への希望、やせたい理由、ダイエット経験の有無、ダイエットの失敗の有無および睡眠時間についての回答の比率に有意な差がみられた。しかしながら、身体活動量はグループ間に差がみられなかった。さらに。EAT-26を用いて食行動を検討すると第3因子「Oral control」においてはHigh groupはLow groupと比較し、有意に高値が認められた。結論 標準体重者で体脂肪率が高い者は、やせ願望やダイエット行動が関連していた。やせ願望の強い学生に対し、適切な体組成の維持と適切な食生活を確立させるための健康教育の必要性が示された。(著者抄録)
  • Harunobu Nakamura; Kumiko Ohara; Katsuyasu Kouda; Yuki Fujita; Tomoki Mase; Chiemi Miyawaki; Yoshimitsu Okita; Tetsuya Ishikawa
    BMC PUBLIC HEALTH 12 432  2012年06月 [査読有り]
     
    Background: In recent years in Japan, electronic games, home computers, and the internet have assumed an important place in people's lives, even for elementary school children. Subjective health complaints have also become a problem among children. In the present study, we investigated the relationship between media use and health status in elementary school children in Japan. Methods: A cross-sectional school-based population survey was conducted in 2009 with a sample of fourth-, fifth-, and sixth-grade children (age range: 10-12 years old) in elementary schools in Japan (n = 3,464). Self-reported health, lifestyle habits, and time spent using media were assessed. Results: The use of games, television, and personal computers was significantly associated with lifestyle (p<0.05) and subjective health (p<0.05). In addition, the use of games, the use of television, and the use of personal computers were mutually associated. The greater the number of media used for more than 1 hour was, the higher the odds ratio of the association of media use with unhealthy lifestyle and subjective health complaints was. The plural use of these media had stronger associations with unhealthy lifestyle and subjective health complaints. Conclusions: Game, television, and personal-computer use were mutually associated, and the plural use of these media had stronger associations with unhealthy lifestyle and subjective health complaints. Excessive use of media might be a risk for unhealthy lifestyle and subjective health complaints.
  • Mase T; Miyawaki C; Kouda K; Fujita Y; Okita Y; Ohara K; Mimasa F; Nakamura H
    [Nihon koshu eisei zasshi] Japanese journal of public health 59 6 371 - 380 2012年06月 [査読有り]
  • 中村 晴信; 沖田 善光; 甲田 勝康; 藤田 裕規; 西尾 信宏; 間瀬 知紀; 宮脇 千惠美; 桑原 恵介; 小原 久未子
    小児保健研究 71 3 405 - 413 (公社)日本小児保健協会 2012年05月 
    本研究においては、小学生を対象として、ゲームの使用状況とゲームに対する意識、および精神・身体症状や家族・友人との関連について検討した。兵庫県A市内の全13小学校の4年生、5年生、6年生計1,323名を対象に、ゲームの使用時間、ゲームに対する意識、生活習慣、精神・身体症状に関する質問紙調査を行った。その結果、ゲームの使用時間が長い者はゲームに対して消極的な印象を持つものが少なく、生活習慣の乱れや精神・身体症状を持つ者や行動が消極的な者が多かった。以上の結果より、ゲームに対する意識は、ゲームの使用時間に影響を与える一因であることが示唆された。(著者抄録)
  • Y. Fujita; M. Iki; J. Tamaki; K. Kouda; A. Yura; E. Kadowaki; Y. Sato; J-S. Moon; K. Tomioka; N. Okamoto; N. Kurumatani
    OSTEOPOROSIS INTERNATIONAL 23 5 1639 - 1640 2012年05月
  • M. Iki; J. Tamaki; Y. Fujita; K. Kouda; A. Yura; E. Kadowaki; Y. Sato; J. S. Moon; K. Tomioka; N. Okamoto; N. Kurumatani
    OSTEOPOROSIS INTERNATIONAL 23 2 761 - 770 2012年02月 
    Recent animal studies have demonstrated that undercarboxylated osteocalcin upregulates insulin secretion via osteoblast-insulin signaling. However, it remains unclear whether such a pathway exists in humans. This study showed that serum undercarboxylated osteocalcin levels were inversely associated with fasting plasma glucose, hemoglobin A(1c), and homeostasis model assessment of insulin resistance (HOMA-IR) levels in community-dwelling elderly Japanese men. Undercarboxylated osteocalcin (ucOC) was reported to increase insulin secretion and improve glucose tolerance via osteoblast-insulin signaling in animal-based studies. Whether this pathway also exists in humans is unknown. We aimed to clarify whether serum ucOC levels are associated with glycemic status and insulin resistance in the general Japanese population. We included 2,174 Japanese men (a parts per thousand yen65 years) who were able to walk without aid from others and lived at home in four cities of Nara Prefecture. We excluded participants with a history of diseases or medications that affect bone metabolism, other than type 2 diabetes mellitus (T2DM). Fasting plasma glucose, glycated hemoglobin A(1c), and HOMA-IR levels were determined as outcome measures. Of the 1,597 participants included in the analysis, both intact OC (iOC) and ucOC levels showed significant inverse correlations with all outcome measures, even after adjusting for potential confounders. Mean values of outcome measures showed a significant decreasing trend with higher quintiles of iOC or ucOC after adjusting for confounders. This trend remained significant for ucOC quintiles after further adjustment for iOC levels, but was not significant for iOC quintiles after adjusting for ucOC levels. These results were attenuated, but still apparent, after excluding participants receiving drug therapy for T2DM. Levels of ucOC, but not iOC, were inversely associated with glycemic index and insulin resistance in a population of Japanese men. These findings will need to be confirmed with longitudinal studies.
  • Y. Fujita; M. Iki; J. Tamaki; K. Kouda; A. Yura; E. Kadowaki; Y. Sato; J. -S. Moon; K. Tomioka; N. Okamoto; N. Kurumatani
    OSTEOPOROSIS INTERNATIONAL 23 2 705 - 714 2012年02月 
    A cross-sectional analysis of 1,662 community dwelling elderly Japanese men suggested that habitual natto intake was significantly associated with higher bone mineral density (BMD). When adjustment was made for undercarboxylated osteocalcin levels, this association was insignificant, showing the natto-bone association to be primarily mediated by vitamin K. Low vitamin K intake is associated with an increased risk of hip fracture, but reports have been inconsistent on its effect on BMD. Our first aim was to examine the association between BMD and intake of fermented soybeans, natto, which contain vitamin K1 (20 mu g/pack) and K2 (380 mu g/pack). Our second aim was to examine the association between undercarboxylated osteocalcin (ucOC), a biomarker of vitamin K intake, and BMD to evaluate the role of vitamin K in this association. Of the Japanese men aged a parts per thousand yen65 years who participated in the baseline survey of the Fujiwara-kyo Osteoporosis Risk in Men study, 1,662 men without diseases or medications known to affect bone metabolism were examined for associations between self-reported natto intake or serum ucOC levels with lumbar spine or hip BMD. The subjects with greater intake of natto showed significantly lower level of serum ucOC. Analysis after adjustment for confounding variables showed an association of greater intake of natto with both significantly higher BMD and lower risk of low BMD (T-score < -1 SD) at the total hip and femoral neck. This association became insignificant after further adjustment for ucOC level. Habitual intake of natto was associated with a beneficial effect on bone health in elderly men, and this association is primarily due to vitamin K content of natto, although the lack of information on dietary nutrient intake, including vitamin K1 and K2, prevented us from further examining the association.
  • 降圧薬と骨代謝指標の関連 藤原京スタディ男性骨折コホート研究の断面検討
    玉置 淳子; 伊木 雅之; 藤田 裕規; 甲田 勝康; 由良 晶子; 門脇 英子; 佐藤 裕保; 文 鐘聲; 冨岡 公子; 岡本 希; 車谷 典男
    Osteoporosis Japan 19 Suppl.1 249 - 249 ライフサイエンス出版(株) 2011年11月 [査読有り]
  • 藤田 裕規; 伊木 雅之
    オステオポローシスジャパン : 日本骨粗鬆症学会雑誌 19 4 592 - 596 ライフサイエンス出版 2011年11月 
    大規模男性骨粗鬆症コホート研究である藤原京スタディ男性骨粗鬆症研究のべースライン調査において、高齢日本人男性について血清クレアチニン値から腎機能を推算したeGFRまたは血清シスタチンC値で評価した腎機能と骨密度や骨代謝マーカーとの関連について検討した。1477例を対象とした。血清クレアチニン値から推定したeGFRは腰椎骨密度、大腿骨近位部骨密度ともに有意な負の関連を示した。eGFRと骨代謝マーカーとの関連をみると血清オステオカルシンとは有意な負の関連を示した。血清シスタチンCにおいては、腰椎骨密度と有意な正の関連を示した。血清シスタチンCと骨代謝マーカーとの関連では、eGFRと同様に血清オステオカルシンとは関連を示した。eGFRはホモシステイン、CRPと有意な関連を示した。血清シスタチンCではホモシステイン、CRP、PTHそれぞれと有意な関連を示した。
  • Katsuyasu Kouda; Yuki Fujita; Harunobu Nakamura; Hiroichi Takeuchi; Masayuki Iki
    JOURNAL OF EPIDEMIOLOGY 21 5 370 - 375 2011年09月 [査読有り]
     
    Background: The effect of recovery from obesity on cardiovascular risk factors is not well understood in Japanese children. Methods: We analyzed follow-up data from the Iwata city population-based study of schoolchildren in Japan. The Iwata Board of Education conducted health screenings of children aged 10 and 14 years. A total of 914 children aged 10 years (451 boys and 463 girls, 87.1% of all children in the city in 1997) were followed until 14 years of age and classified by pattern of obesity as Normal, Recovered, Worsened, or Persistent. Results: Of the 914 children, I I 1 (12%) were obese at 10 years of age. Of those children, 44 (40%) were no longer obese at 14 years (ie, Recovered). At follow-up, Recovered boys had the greatest decrease in non-HDL cholesterol (mean +/- SE, -21.3 +/- 3.6 mg/dL) among the 4 groups, and Recovered girls had a significantly lower level of non-HDL cholesterol (Recovered, 107.1 +/- 5.4 mg/dL vs. Persistent, 126.1 +/- 4.5 mg/dL). The Recovered boys also had a significantly higher level of HDL cholesterol at age 14 (Recovered, 67.2 +/- 2.7 mg/dL vs. Persistent, 53.3 +/- 2.1 mg/dL). In the Recovered group, 68% of children who were dyslipidemic at baseline had normal cholesterol levels at age 14. The recovery rate from dyslipidemia was significantly higher in the Recovered group (cumulative incidence rate ratio, 2.5; 95% confidence interval, 1.4-4.7) as compared with the Persistent group. Conclusions: Dyslipidemia was reversed in children who recovered from obesity. Our findings suggest that reducing obesity is beneficial to the health of Japanese schoolchildren.
  • Katsuyasu Kouda; Masayuki Iki; Yuki Fujita; Junko Tamaki; Akiko Yura; Eiko Kadowaki; Yuho Sato; Jong-Seong Moon; Masayuki Morikawa; Kimiko Tomioka; Nozomi Okamoto; Norio Kurumatani
    BONE 49 2 275 - 280 2011年08月 [査読有り]
     
    There are no data concerning a relationship between alcohol and bone status from a large-scale community-based study of elderly Japanese men. The baseline survey for the Fujiwara-kyo Osteoporosis Risk in Men Study was performed in 2174 male participants during the period from 2007 to 2008 in Nara Prefecture, Japan. Among them 1665 fitted the following inclusion criteria: (a) age >= 65 years, (b) no diseases or drug therapy that could affect bone mineral density (BMD). We analyzed 1421 men with complete information about alcohol intake. We found that alcohol intake and BMD were positively correlated after adjustment for age, body mass index, natto intake, milk intake, smoking, physical activity, education, marital status, and hypertension. Adjusted total hip BMD of men with alcohol intake >39 g/day was 0.90 g/cm(2) and that of abstainers was 0.85 g/cm(2). With regard to bone turnover markers, alcohol intake was inversely associated with serum levels of osteocalcin and tartrate-resistant acid phosphatase isoenzyme 5b. A two-piece linear regression model revealed a positive relationship between alcohol intake and crude mean BMD for the total hip in those with alcohol intake of less than 55 g/day. In contrast, alcohol intake and BMD in those with an alcohol intake of 55 g/day or more was inversely correlated. The present large-scale study of elderly Japanese men revealed that although an alcohol intake of <55 g/day was positively correlated to BMD, alcohol intake of >= 55 g/day was inversely correlated to BMD. (C) 2011 Elsevier Inc. All rights reserved.
  • Yuki Fujita; Katsuyasu Kouda; Harunobu Nakamura; Masayuki Iki
    JOURNAL OF EPIDEMIOLOGY 21 3 191 - 196 2011年05月 [査読有り]
     
    Background: School-based screening and prevention programs for adiposity generally target school children in grades 4 and 6 (age 9-11 years). The aims of this study were to evaluate the validity of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) in identifying abdominal adiposity in fifth-grade Japanese school children and to determine optimal cut-off values for anthropometric measures. Methods: The target population was fifth-grade school children enrolled in 2 schools in Shizuoka, Japan between 2008 and 2010; 422 of the 466 children participated in the present study. Abdominal adiposity was defined as percent trunk fat in the 95th percentile or higher, as determined by dual-energy x-ray absorptiometry (DXA). We analyzed the validity of BMI, WC, and WHtR using receiver operating characteristic (ROC) curve analysis. The Youden index was used to determine cut-off values of BMI, WC, and WHtR that identify excess abdominal fat. Results: Optimal cut-off values to identify abdominal adiposity were 20.8 kg/m(2) (BMI), 76.5 cm (WC), and 0.519 (WHtR) for boys, and 19.6 kg/m(2) (BMI), 73.0 cm (WC), and 0.499 (WHtR) for girls. Areas under the ROC curve were 0.983 (BMI), 0.987 (WC), and 0.981 (WHtR) for boys, and 0.981 (BMI), 0986 (WC), and 0.992 (WHtR) for girls. Conclusions: BMI, WC, and WHtR successfully identified a high proportion of children with excess abdominal fat as measured by DXA, demonstrating that these measures are useful indices for school screening.
  • Yuki Fujita; Masayuki Iki; Yukihiro Ikeda; Akemi Morita; Tomoharu Matsukura; Harumi Nishino; Takashi Yamagami; Sadanobu Kagamimori; Yoshiko Kagawa; Hideo Yoneshima
    JOURNAL OF BONE AND MINERAL METABOLISM 29 2 208 - 216 2011年03月 [査読有り]
     
    Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral density (aBMD) from pre-puberty to 6-year follow-up, and to determine the target period to achieve maximal peak aBMD. This study was conducted as the pediatric part of a larger cohort study, the Japanese Population-based Osteoporosis (JPOS) study. Of 448 children aged 9-12 years who completed the baseline survey, 225 participated in the follow-up study 6 years later (follow-up rate: 50.2%). aBMD at the forearm was measured using dual-energy X-ray absorptiometry. aBMD values in pre-pubertal children at baseline showed a significant tracking correlation with aBMD obtained at 6-year follow-up in both genders (boys r = 0.655, girls r = 0.759). Although boys and girls in the lowest quartile of aBMD pre-pubertally had greater annual increases in aBMD from pre-puberty to 6-year follow-up than those in other aBMD quartiles, they still showed the lowest mean aBMD at 6-year follow-up. Children with lower pre-pubertal aBMD showed greater increases in BMD up until 6-year follow-up, but the increase was not great enough to catch up with other children. About 50% of the variance in aBMD at 6-year follow-up was determined by the aBMD achieved during the pre-pubertal period. Activities that increase aBMD are important not only for children during puberty, but also for younger pre-pubertal children.
  • Yuki Fujita; Katsuyasu Kouda; Harunobu Nakamura; Nobuhiro Nishio; Hiroichi Takeuchi; Masayuki Iki
    JOURNAL OF EPIDEMIOLOGY 21 2 102 - 107 2011年03月 [査読有り]
     
    Background: Inverse associations between height and serum lipid levels in pubertal children have been reported. To develop criteria for normal serum lipid levels stratified by height in pubertal children, we examined height-specific cholesterol levels, using data from a population-based school screening. Methods: Serum levels of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were investigated in 10 151 children (98.9% of the target population) aged 10 and 14 years who attended public schools in Iwata City from 2002 through 2007. Results: The 95th percentiles of TC in the lowest and highest quintiles of height were 221 and 219 mg/dL, respectively, in 10-year-old boys, 215 and 203 mg/dL in 14-year-old boys, 220 and 204 mg/dL in 10-year-old girls, and 226 and 214 mg/dL in 14-year-old girls. The fifth percentiles of HDL-C in the lowest and highest quintiles of height were 45 and 43 mg/dL in 10-year-old boys, 43 and 40 mg/dL in 14-year-old boys, 46 and 42 mg/dL in 10-year-old girls, and 47 and 44 mg/dL in 14-year-old girls. Conclusions: This study provided height-specific levels of serum lipids in 10-year-old and 14-year-old children. Height should be considered when evaluating cholesterol levels in pubertal children.
  • J. Tamaki; M. Iki; Y. Fujita; K. Kouda; A. Yura; E. Kadowaki; Y. Sato; J. S. Moon; K. Tomioka; N. Okamoto; N. Kurumatani
    OSTEOPOROSIS INTERNATIONAL 22 1 133 - 141 2011年01月 
    Our cross-sectional analysis of 1,576 men aged a parts per thousand yen65 years examined smoking effects on bone status. Number of smoking years was associated with decreased bone mineral density (BMD), after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not affect biochemical marker serum values for bone turnover. The impact of smoking on bone status in men has not been conclusively established. We examined how smoking and its cessation influence bone status and metabolism in men. We analyzed 1,576 men among a baseline survey of Japanese men aged a parts per thousand yen65 years, the Fujiwara-kyo Osteoporosis Risk in Men study, conducted during 2007-2008. Lumbar spine (LS) BMD values among never, former, and current smokers were 1.045 +/- 0.194, 1.030 +/- 0.189, and 1.001 +/- 0.182 g/cm(2) (P = 0.005), respectively, while total hip (TH) BMD values were 0.888 +/- 0.120, 0.885 +/- 0.127, and 0.870 +/- 0.124 (P = 0.078), respectively. The significant trend for LS BMD remained after adjusting for the covariates; age, height, weight, physical activity, milk consumption, and drinking habit (P = 0.036). Among never and ever (current and former) smokers, LS and TH BMD decreased with the number of pack years or the number of smoking years, respectively, adjusted for those covariates. Among ever smokers, LS and TH BMD decreased with the number of smoking years after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not reveal significant effect for serum osteocalcin or tartrate resistant acid phosphatase isoenzyme 5b. The impact of smoking on bone status is mainly associated with the number of smoking years in elderly men.
  • J. Tamaki; M. Iki; Y. Fujita; K. Kouda; A. Yura; E. Kadowaki; Y. Sato; J. S. Moon; K. Tomioka; N. Okamoto; N. Kurumatani
    OSTEOPOROSIS INTERNATIONAL 22 1 133 - 141 2011年01月 
    Our cross-sectional analysis of 1,576 men aged a parts per thousand yen65 years examined smoking effects on bone status. Number of smoking years was associated with decreased bone mineral density (BMD), after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not affect biochemical marker serum values for bone turnover. The impact of smoking on bone status in men has not been conclusively established. We examined how smoking and its cessation influence bone status and metabolism in men. We analyzed 1,576 men among a baseline survey of Japanese men aged a parts per thousand yen65 years, the Fujiwara-kyo Osteoporosis Risk in Men study, conducted during 2007-2008. Lumbar spine (LS) BMD values among never, former, and current smokers were 1.045 +/- 0.194, 1.030 +/- 0.189, and 1.001 +/- 0.182 g/cm(2) (P = 0.005), respectively, while total hip (TH) BMD values were 0.888 +/- 0.120, 0.885 +/- 0.127, and 0.870 +/- 0.124 (P = 0.078), respectively. The significant trend for LS BMD remained after adjusting for the covariates; age, height, weight, physical activity, milk consumption, and drinking habit (P = 0.036). Among never and ever (current and former) smokers, LS and TH BMD decreased with the number of pack years or the number of smoking years, respectively, adjusted for those covariates. Among ever smokers, LS and TH BMD decreased with the number of smoking years after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not reveal significant effect for serum osteocalcin or tartrate resistant acid phosphatase isoenzyme 5b. The impact of smoking on bone status is mainly associated with the number of smoking years in elderly men.
  • 玉置 淳子; 伊木 雅之; 藤田 裕規; 門脇 英子
    Osteoporosis Japan 18 4 643 - 648 ライフサイエンス出版(株) 2010年10月 
    「藤原京スタディ男性骨粗鬆症コホート研究」でベースライン調査を行った65歳以上の男性1632人(平均73.0歳)を対象に、HMG-CoA還元酵素阻害剤(スタチン)服用者110人と非服用者1522人に分け、腰椎と大腿骨近位部の骨密度を測定し、骨代謝マーカーへの影響を検討した。2群間の比較では、服用群でBMI高値・高血圧者の割合が有意に高く、総コレステロール・LDLコレステロールが有意に低かった。腰椎と大腿骨近位部の骨密度に有意差はなかったが、骨形成マーカーの血清オステオカルシン(OC)・骨吸収マーカーの血清TRACP-5bは服用群で有意に低値であった。非服用群では飲酒習慣(6回/週以上)の割合が有意に多く、身体活動量が多い傾向であった。2群間で腰椎・大腿骨近位部の調整骨密度に有意差はなかったが、調整したOC値とTRACP-5b値は服用群で有意に低かった。スタチン服用は骨密度減少の抑制効果を有すると考えられた。
  • Yuki Fujita; Katsuyasu Kouda; Harunobu Nakamura; Nobuhiro Nishio; Hiroichi Takeuchi; Masayuki Iki
    PEDIATRICS INTERNATIONAL 52 5 689 - 693 2010年10月 [査読有り]
     
    Background: Blood pressure examinations for health education use have been conducted at several schools in Japan. It has been reported that blood pressure is closely associated with bodyweight and height in US children. The aim of the present paper was to evaluate the association between height and blood pressure in Japanese schoolchildren. Methods: In Iwata city in Japan, blood pressure screening was conducted by the school administration. A total of 98.9% (10 152/10 270 children) of all fifth (10-year-olds) and ninth graders (14-year-olds) residing in the Old Iwata area from 2002 to 2007 were analyzed. Results: In 10-year-old and 14-year-old boys, regression analysis indicated that a positive correlation between weight and blood pressure was the strongest among the three body size indices (height, weight, and body mass index), but the association between height and blood pressure was also significant. For girls from both the 10 and 14 year age groups, the correlation of weight and blood pressure was stronger than those for the other body size indices, but there were also significant associations between height and blood pressure, except for height and diastolic blood pressure in the 14-year-olds. Conclusions: There is a significant positive relationship between height and blood pressure. Further study is necessary to provide a blood pressure reference based on height in the Japanese program to prevent children from developing lifestyle-related risk factors.
  • Katsuyasu Kouda; Harunobu Nakamura; Nobuhiro Nishio; Yuki Fujita; Hiroichi Takeuchi; Masayuki Iki
    JOURNAL OF EPIDEMIOLOGY 20 3 212 - 218 2010年05月 [査読有り]
     
    Background: Current trends in body size, blood pressure, and serum lipids in children are predictors of future disease prevalence. However, there have been no studies of blood pressure and high-density lipoprotein cholesterol (HDL-C) levels in Japanese children. Methods: We investigated trends in body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), non-HDL-C, and HDL-C using data from annual screenings in 1993 through 2008. The subjects were 14 872 (98.8% of the target population) fifth-graders enrolled in all public schools in the Original Iwata area in Iwata City, Japan. The same examination protocol was used throughout to ensure the uniformity of quality control and the precision of assessment. Trends in the variables in relation to the calendar year were analyzed by using regression models. Results: In boys, the 95th percentile of BMI increased by 0.09 kg/m(2)/year. In both sexes, the 5th percentile of BMI decreased by 0.02 to 0.03 kg/m(2)/year. There was a significant negative correlation between SBP and calendar year, and the 95th percentile of SBP decreased by 0.52 mm Hg/year in boys and by 0.40 mm Hg/year in girls. There was also a significant reduction DBP. However, there were no trends in TC, non-HDL-C, or HDL-C. Conclusions: The increase in obese and underweight children in Original Iwata was consistent with the findings of a nationwide survey. Although high blood pressure and related risk factors were formerly a serious problem in Japan, blood pressure levels have decreased in schoolchildren from Iwata over the past 15 years.
  • Masayuki Iki; Yuki Fujita; Junko Tamaki; Katsuyasu Kouda; Akiko Yura; Eiko Kadowaki; Yuho Sato; Jong-Seong Moon; Nozomi Okamoto; Norio Kurumatani
    BMC MUSCULOSKELETAL DISORDERS 10 165  2009年12月 [査読有り]
     
    Background: Osteoporosis and osteoporotic fracture in men are significant public health problems in an aging society. However, information on male osteoporosis remains impressively lacking, especially for Asians. We designed the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study as an ancillary study of a cohort study, the Fujiwara-kyo study, to determine risk factors for osteoporotic fractures in Japanese men. Methods/Design: Design: A community-based single-centre prospective cohort study with at least a 5-year follow-up Subjects: All the male participants of the Fujiwara-kyo study who were living in the four cities studied, aged 65 years and older, and able to walk without aid from others. Primary outcome: Incidence of osteoporotic fractures including vertebral and clinical non-vertebral fractures. Additional outcomes: Change in bone mineral density (BMD), change in hip geometry, onset of receiving benefits from Long-term Care Insurance (LCI), health-related quality of life, and mortality. Baseline measurements: BMD at the lumbar spine (LS) and hip (TH), hip geometry, vertebral deformity assessment, bone turnover markers, physical and cognitive performance, various medical and lifestyle factors, and geriatric psychosocial measures confirmed by interviews based on self-administrated questionnaires. Outcome surveillance: Annual mail surveys and a follow-up survey at the fifth year comprising similar items to the baseline study will be used to determine the outcomes. Receipt of benefits from LCI and mortality will be obtained from the city governments. Current status: The baseline study was conducted for 2174 eligible men, and 2012 completed the study and were eligible for follow-up. Prevalence rates of osteoporosis (BMD 2.5 SD or more below the young adult mean (YAM)) and low BMD (BMD 1 SD or more below YAM) in at least one of LS and TH were calculated to be 4.4% and 41.8%, respectively. The proportion of men with low BMD only at TH showed a significant increasing trend with aging (p < 0.0001) while that only at LS showed a decreasing trend (p = 0.0386). The prevalence rate of osteoporosis was underestimated when diagnosed using only BMD at LS. Other baseline measurements were successfully obtained. Discussion: FORMEN baseline study was performed as designed and the FORMEN cohort study was successfully launched.
  • Kazuhiko Kotani; Kenji Wakai; Akira Shibata; Yuki Fujita; Itsuro Ogimoto; Mariko Naito; Yoichi Kurozawa; Hiroshi Suzuki; Takesumi Yoshimura; Akiko Tamakoshi
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 10 87 - 90 2009年12月 [査読有り]
     
    Evidence suggests a link between adiponectin, an adipocytokine, and liver tumorigenesis. Different multimer complexes of adiponectin, with low-molecular weight (LMW), middle-molecular weight (MMW) and high-molecular weight (HMW), may have different roles. Therefore the present study was performed with the aim of assessing associations between these multimers and liver cancer development. A nested case-control study (59 liver cancer cases [mean age=63.5 years] and 334 controls [62.7 years]) was conducted as a part of the Japan Collaborative Cohort (JACC) Study recruiting healthy participants, aged 40-79 years, for the follow-up period from 1988-1990 to 1999. The end point was liver cancer occurrence/death. Serum levels of HMW, MMW and LMW adiponectin were determined at baseline using an ELISA assay. Multivariate-adjusted logistic regression analyses comparing the tertile levels of adiponectin multimers showed that the groups stratified with the highest percentage of LMW tended to have lower odds ratios (ORs) than the lowest group (OR adjusted for sex, age and area=0.54 [95% CI: 0.26-1.11] and adjusted for sex, age, area, body mass index, smoking, alcohol, coffee consumption, diabetes history and HCV-antibody positivity = 0.50 [95% CI: 0.22-1.15]), albeit without statistical significance (set at p<0.05). Higher percentages of circulating LMW adiponectin may lead to a reduction of liver cancer risk and relationships with multimer composition may merit further study.
  • 中村 晴信; 甲田 勝康; 石川 哲也; 西尾 信宏; 藤田 裕規; 沖田 善光; 桑原 恵介
    日本未病システム学会雑誌 15 1 24 - 27 (一社)日本未病システム学会 2009年07月 
    保健室を訪問する小学生児童について、疲労に関する調査を行い、保健指導として乾湿双方のタオルを用いた皮膚刺激を試行した。自覚症状を訴えて保健室を訪問した児童11例を対象にし、訪問時に質問紙による疲労度調査とタオルを使用して皮膚への刺激を行った。疲労度調査票は、I群「眠気とだるさ」、II群「注意集中の困難」、III群「局在した身体違和感」からなる。皮膚刺激の希望については、乾きタオルを選択した者は54例、しぼりタオルを選択した者は61例であった。乾きタオル選択者はIII群を除いていずれの群も、また、しぼりタオル選択者はいずれの群においても皮膚刺激後の疲労度得点が有意に減少した。しぼりタオルを選択した者は乾きタオルを選択した者に比べ、I群、II群、III群、および全群合計において皮膚刺激前の疲労度の得点が有意に高かった。皮膚刺激後においては、乾きタオルとしぼりタオル選択者間に有意差はなかった。
  • M. Iki; J. Tamaki; Y. Sato; E. Kadowaki; Y. Fujita; K. Kouda; Y. Ikeda; A. Morita; E. Kajita
    BONE 45 S97 - S97 2009年07月 [査読有り]
  • 男性の骨粗鬆症とそれによる要介護化を防止する知・体・食・住への総合的アプローチ
    玉置 淳子; 藤田 裕規; 伊木 雅之; 森川 将行
    財団法人総合健康推進財団平成19年度研究報告書 24 40 - 55 2009年
  • 伊木 雅之; 玉置 淳子; 門脇 英子; 藤田 裕規
    Osteoporosis Japan 16 4 680 - 684 ライフサイエンス出版(株) 2008年10月 
    小学校高学年から中学3年生までの健常日本人コホートを6年間追跡し、その間に発生した骨折のリスク要因を多面的に検討した。F県S町立小学校4校の4年生、および同町立中学校の各学年男女からそれぞれ50人を無作為抽出し、初回調査を受診した585人のうち3年後に同町に在住していた570人を対象に第2回調査を行い、6年後に同町に在住していた者のうち初回調査時に小学生であった287人を対象に第3回調査を行った。その結果、骨折の有意なリスク要因として、男子で「小柄であること」と「総運動時間が長いこと」、女子で「小柄であること」と「二次性徴発来前であること」が抽出された。
  • 小学生から高校生にいたる中軸骨骨発達の6年間追跡に基づく思春期骨折のリスク要因の解明と骨折予防プログラムの立案
    伊木 雅之; 玉置 淳子; 藤田 裕規; 甲田 勝康; 由良 晶子; 門脇 英子; 梶田 悦子
    社団法人日本酪農乳業協会、平成19年度牛乳栄養素等調査研究及び牛乳・乳製品機能性実証調査報告書 51 - 88 2008年
  • K. Wakai; Y. Kurozawa; A. Shibata; Y. Fujita; K. Kotani; I. Ogimoto; M. Naito; K. Nishio; H. Suzuki; T. Yoshimura; A. Tamakoshi
    BRITISH JOURNAL OF CANCER 97 3 426 - 428 2007年07月 [査読有り]
     
    We examined hepatocellular carcinoma mortality in relation to coffee consumption and anti- hepatitis C virus ( HCV) antibody seropositivity in a nested case - control study involving 96 cases. The multivariate- adjusted odds ratios ( 95% confidence interval) for daily coffee drinkers vs non- drinkers were 0.49 ( 0.25 - 0.96), 0.31 ( 0.11 - 0.85), and 0.75 ( 0.29 - 1.92) in all cases, in HCV- positive and in HCV- negative individuals, respectively.
  • Yuki Fujita; Akira Shibata
    Traffic Injury Prevention 7 4 325 - 327 2006年12月 [査読有り]
     
    Objective. The present study was performed to clarify the relation between alcohol use and traffic fatalities in accidents involving motor vehicles in Japan. Methods. Data on traffic accidents were collected from Fukuoka Prefectural Police records of traffic accidents which occurred in that prefecture between 1987 and 1996. Multiple logistic regression models were used to assess the effect of alcohol use on the risk of traffic-accident death. Results. The data showed that 58,421 male drivers were involved in traffic accidents during the 10-year study period, and that 271 of these were killed as a result of the accident. Alcohol use was significantly associated with speed, seat belt use, time, and road form. Among male motorcar drivers, the odds ratio of alcohol use before driving, after adjusting for age, calendar year, time, and road form, was 4.08 (95% confidence interval, 3.08-5.40), which means that about 75% of fatalities (attributable risk percent among exposed) might have been prevented if drivers had not drunk before driving. Conclusions. Alcohol use before driving resulted in a 4.08-fold increase in the risk of death in a traffic accident. It is suggested that alcohol use is considered an important risk factor for fatality in traffic accidents. Copyright © 2006 Taylor & Francis Group, LLC.
  • Y Fujita; A Shibata; Ogimoto, I; Y Kurozawa; T Nose; T Yoshimura; H Suzuki; N Iwai; R Sakata; S Ichikawa; A Tamakoshi
    BRITISH JOURNAL OF CANCER 94 5 737 - 739 2006年03月 [査読有り]
     
    We evaluated the interaction between hepatitis C virus ( HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 ( 1.50 - 61.35) and 1.71( 0.58 - 5.08) among anti-HCV positive and negative individuals, respectively.
  • Y Kurozawa; Ogimoto, I; A Shibata; T Nose; T Yoshimura; H Suzuki; R Sakata; Y Fujita; S Ichikawa; N Iwai; A Tamakoshi
    BRITISH JOURNAL OF CANCER 93 5 607 - 610 2005年09月 [査読有り]
     
    We examined the relation between coffee drinking and hepatocellular carcinoma (HCC) mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). In total, 110 688 cohort members ( 46 399 male and 64 289 female subjects) aged 40 - 79 years were grouped by coffee intake into three categories: one or more cups per day, less than one cup per day and non-coffee drinkers. Cox proportional hazards model by SAS was used to obtain hazard ratio of HCC mortality for each coffee consumption categories. The hazard ratios were adjusted for age, gender, educational status, history of diabetes and liver diseases, smoking habits and alcohol. The hazard ratio of death due to HCC for drinkers of one and more cups of coffee per day, compared with non-coffee drinkers, was 0.50 (95% confidence interval 0.31 - 0.79), and the ratio for drinkers of less than one cup per day was 0.83 ( 95% confidence interval 0.54 - 1.25). Our data confirmed an inverse association between coffee consumption and HCC mortality.
  • Youichi Kurozawa; Itsuro Ogimoto; Akira Shibata; Takayuki Nose; Takesumi Yoshimura; Hiroshi Suzuki; Ritsu Sakata; Yuki Fujita; Shoko Ichikawa; Nobuo Iwai; Katsuhiro Fukuda; Akiko Tamakoshi
    Kurume Medical Journal 51 2 141 - 149 2004年 [査読有り]
     
    To explore the association between dietary habits and risk of hepatocellular carcinoma (HCC) mortality in Japan, univariate analyses was performed using data from the JACC Study. A cohort of 46,465 males and 64,327 females aged 40 to 79 in 19 prefectures in Japan completed the baseline survey during 1988-1990 and were followed up until the end of 1999. The hazard ratio (HR) of HCC mortality for each food item by gender, age group (40-59 and 60-79 years) and history of liver diseases was obtained by Cox proportional hazards model. Some categories, such as boiled rice, ham and sausage, chicken, fish and pickles among men without history of liver diseases and those of miso-soup, fish, carrots and squash, and potatoes among women without history of liver diseases showed a significant inverse association with HCC mortality. Frequent intake of eggs was significantly associated with increased HCC mortality in men without history of liver diseases. Potatoes and foods boiled down in soy sauce (tsukudani) showed a significant positive association, and pickles had a significant inverse association with HCC mortality in men with history of liver diseases. Frequent intake of coffee showed a significant inverse association with HCC mortality both in men and women with history of liver diseases. It is considered that further analysis using a multivariate Cox proportional hazards model including other confounding factors will be required for a more meaningful interpretation of the data.
  • Itsuro Ogimoto; Akira Shibata; Youichi Kurozawa; Takayuki Nose; Takesumi Yoshimura; Hiroshi Suzuki; Nobuo Iwai; Ritsu Sakata; Yuki Fujita; Shoko Ichikawa; Katsuhiro Fukuda; Akiko Tamakoshi
    Kurume Medical Journal 51 1 59 - 70 2004年 [査読有り]
     
    Hazard ratios (HR) of death due to hepatocellular carcinoma (HCC) were analyzed by gender and age strata (40-59 and 60-79) among drinkers and ex-drinkers in 66,974 eligible subjects from a a large cohort of male and female subjects aged 40-79 years, based on information about several drinking related characteristics. The HR of dying from HCC for ex-drinkers was 4 to 8 times higher than for those who had never consumed alcohol at the baseline survey. When the subjects were restricted to those without history of liver disease (LD), the HR was still high for ex-drinkers among younger males, though the difference was not statistically significant. It appeared that the earlier drinking habits were established, the higher the HR, especially for younger males without LD. Among total current drinkers, the amount ingested per occasion and the cumulative amount ingested at the baseline did not show significantly increased HRs. Among subjects without LD, larger amounts ingested per occasion and larger cumulative amount seemed to have higher HRs in older male current drinkers. Frequent drinking and later age (50 to 79) at cessation of drinking were associated with higher HRs among both genders and both age strata. After restricting the analysis to subjects without LD, many of these increased HRs remained among males. The results suggested that the association between alcohol drinking history and HR of HCC differs depending on the presence of LD. Major confounders other than age and gender associated with both drinking and HCC, e.g. smoking, hepatitis virus infection, or history of diabetes, were not considered in this analysis, and the observed associations might be confounded by any of these factors. To clarify the net association between alcohol drinking and HCC, further analysis is needed to control potential confounders, including past history of liver disease, and to consider probable effect modifiers.
  • Itsuro Ogimoto; Akira Shibata; Youichi Kurozawa; Takayuki Nose; Takesumi Yoshimura; Hiroshi Suzuki; Nobuo Iwai; Ritsu Sakata; Yuki Fujita; Shoko Ichikawa; Katsuhiro Fukuda; Akiko Tamakoshi
    Kurume Medical Journal 51 1 71 - 81 2004年 [査読有り]
     
    Hazard ratios (HR) of death due to hepatocellular carcinoma (HCC) were analyzed by gender and age strata (40-59 and 60-79) among smokers and ex-smokers in 65,528 eligible subjects from a large cohort of males and females aged 40-79 years, based on information about several smoking-related characteristics. Both current smokers and ex-smokers among total older males had hazard ratios (HR) for dying from HCC that were 2 to 4 times higher than those who had never smoked at the baseline survey. When subjects were restricted to those without history of liver disease (LD), older male (60-79) ex-smokers presented a statistically significant HR of 5.0. Earlier age at start of smoking (15 to 19) showed a significantly increased HR of 4 to 8 for both current and ex-smokers. Moderate number of cigarettes smoked per day showed an increased HR, and later age at cessation of smoking had a higher HR compared to earlier cessation. Larger cumulative amount of smoking resulted in an elevated HR of 11 times than in those who had never smoked. Cigarette smoking was suggested to be an important risk factor for death from HCC regardless of whether the smoking habit was in the past or was continuing at present. To eliminate confounding effects and interaction with other risk factors of HCC and to clarify the net association between smoking habits and HCC, farther careful analysis using multivariate models is needed.
  • Akira Shibata; Itsuro Ogimoto; Youichi Kurozawa; Takayuki Nose; Takesumi Yoshimura; Hiroshi Suzuki; Nobuo Iwai; Ritsu Sakata; Yuki Fujita; Shoko Ichikawa; Katsuhiro Fukuda; Akiko Tamakoshi
    Kurume Medical Journal 50 3-4 109 - 119 2003年 [査読有り]
     
    The relationship between the past history of selected diseases and the risk of dying from hepatocellular carcinoma (HCC) was analyzed using 110,792 cohort members (46,465 males and 64,327 females) recruited between 1988 and 1990 by the JACC Study (the Japan Collaborative Cohort Study for Evaluation of Cancer Risk). Significantly elevated hazard ratios (HRs) were observed in both genders for the past history of kidney diseases, liver diseases, gall-stones or cholecystitis, diabetes mellitus, and blood transfusion. Further, when analyzed by age group (those 40-59 years of age were "younger" and those 60-79 years of age were "older"), although the significant associations were generally maintained, the magnitude of the HRs for liver diseases and diabetes mellitus seemed to be considerably different between the younger and older age groups for male cohort members. When the analyses were limited to cohort members without the past history of liver diseases, the past histories which had significantly elevated HRs were hypertension (HR=3.14, 95% confidence interval (Cl): 1.25-7.89), diabetes mellitus (HR=4.17, 95% Cl: 1.22-14.25), and blood transfusion (HR=7.69, 95% Cl: 3.09-19.15) in the younger male age group and gallstone or cholecystitis (HR=2.58, 95% Cl: 1.11-5.98) in the older male age group. On the other hand, for females, the significantly elevated HRs were gastric or duodenal ulcer (HR=4.33, 95% Cl: 1.09-17.25) in the younger age group and diabetes mellitus (HR=6.16, 95%Cl: 2.25-16.90) and blood transfusion (HR=3.86, 95%Cl: 1.58-9.41) in the older age group. However, since the evidence from our univariate analyses might not be decisive, multivariate Cox proportional hazards models controlling for potential confounders and effect modifiers will be required to obtain more valid or unbiased hazard ratios.

講演・口頭発表等

  • Ideal body image and eating behaviors in Japanese young adults  [通常講演]
    甲田 勝康; 藤田 裕規; Ohara K Kato; Y; Mase T; Miyawaki C; Nakamura H; Okita Y
    20th European Congress on Obesity 2013年05月 Liverpool 20th European Congress on Obesity
  • Body shape and the related factors in Japanese university students  [通常講演]
    甲田 勝康; 藤田 裕規; Nakamura H Ohara; K Mase T; Miyawaki; C; Kato Y; Okita Y
    20th European Congress on Obesity 2013年05月 Liverpool 20th European Congress on Obesity
  • Increased trunk-to-appendicular fat ratio is associated with decreased adiponectin concentrations independently of whole body fat in a general population of japanese children  [通常講演]
    甲田 勝康; 藤田 裕規; 伊木 雅之; Nakamura H; Ohara K
    20th European Congress on Obesity 2013年05月 Liverpool 20th European Congress on Obesity
  • Increased trunk-to-appendicular fat ratio is associated with low serum HDL cholesterol levels independently of total adiposity in japanese children  [通常講演]
    藤田 裕規; 甲田 勝康; 伊木 雅之; Nakamura H; Ohara K
    20th European Congress on Obesity 2013年05月 Liverpool 20th European Congress on Obesity
  • 日本人小学生における体脂肪分布パターンと第二次性徴との関連:二重エネルギーX線吸収法による検討  [通常講演]
    甲田 勝康; 藤田 裕規; 伊木 雅之; 中村晴信; 小原
    第23回日本疫学会学術総会 2012年12月 吹田 第23回日本疫学会学術総会
  • Incident clinical fracture increases the risk of mortality in community-dwelling elderly men: Fujiwara-Kyo Osteoporosis Risk In Men (FORMEN) Study  [通常講演]
    伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; Kadowaki E; Sato Y; Moon JS; Harano A; Hazaki K; Okamoto N; Kurumatani N
    International Osteoporosis Foundation (IOF) Regionals-3rd Asia-Pacific Osteoporosis Meeting 2012年12月 Kuala Lumpur International Osteoporosis Foundation (IOF) Regionals-3rd Asia-Pacific Osteoporosis Meeting
  • 女子学生における肥満意識と食行動との関連  [通常講演]
    間瀬知紀; 甲田 勝康; 藤田 裕規; 宮脇千恵美; 小原久未子; 石川哲也; 川畑徹朗; 辻本悟史; 加藤佳子; 中村晴信
    第59回日本学校保健学 2012年11月 神戸 第59回日本学校保健学
  • 大学生における運動習慣背景要因 -家族友人の存在と運動への意識-  [通常講演]
    宮脇千惠美; 甲田 勝康; 藤田 裕規; 間瀬知紀; 小原久未子; 加藤佳子; 辻本悟史; 川畑徹朗; 石川哲也; 中村晴信
    第59回日本学校保健学会 2012年11月 神戸 第59回日本学校保健学会
  • 大学生の食行動と食欲および気分との関連  [通常講演]
    小原久未子; 甲田 勝康; 藤田 裕規; 加藤佳子; 間瀬知紀; 宮脇千惠美; 川畑徹朗; 辻本悟史; 石川哲也; 中村晴信
    第59回日本学校保健学会 2012年11月 神戸 第59回日本学校保健学会
  • 兵庫県におけるスクールヘルスリーダー派遣事業の現状と課題  [通常講演]
    中村晴信; 甲田 勝康; 藤田 裕規; 小原久未子; 間瀬知紀; 宮脇千惠美; 川畑徹朗; 辻本悟史; 加藤佳子; 石川哲也
    第59回日本学校保健学会 2012年11月 神戸 第59回日本学校保健学会
  • 高齢男性の新規骨折は生命予後を悪化させる:藤原京スタディ男性骨粗鬆症研究  [通常講演]
    伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 原納明博; 羽崎完; 岡本希 車谷典男
    第71回日本公衆衛生学会総会 2012年10月 山口 第71回日本公衆衛生学会総会
  • 妊娠期の母親の体重変化が中学生の血圧に及ぼす影響  [通常講演]
    藤田 裕規; 甲田 勝康; 伊木 雅之; 中村晴信
    第71回日本公衆衛生学会総会 2012年10月 山口 第71回日本公衆衛生学会総会
  • 妊娠期の母親の体重変化が中学生の血圧に及ぼす影響  [通常講演]
    藤田 裕規; 甲田 勝康; 伊木 雅之; 中村晴信
    第71回日本公衆衛生学会総会 2012年10月 山口 第71回日本公衆衛生学会総会
  • 日本人小学生における血中25-Hydroxyvitamin D濃度と体組成との関係  [通常講演]
    甲田 勝康; 藤田 裕規; 伊木 雅之; 中村晴信
    第71回日本公衆衛生学会総会 2012年10月 山口 第71回日本公衆衛生学会総会
  • 閉経女性における体組成と骨密度の関連-JPOS Study 15年次調査による閉経後年数別検討  [通常講演]
    玉置 淳子; 伊木 雅之; 由良 晶子; 甲田 勝康; 藤田 裕規; 冬梅; 佐藤裕保; 梶田悦子; 中谷芳美; 鏡森定信; 香川芳子; 米島秀夫
    第71回日本公衆衛生学会総会 2012年10月 山口 第71回日本公衆衛生学会総会
  • 摂食障害発症の関連要因に関する文献学的検討  [通常講演]
    小原久未子; 甲田 勝康; 藤田 裕規; 中村晴信; 間瀬知紀; 宮脇千恵美; 川畑徹朗; 辻本悟史; 加藤佳子; 石川哲也; 桑原恵介
    第58回日本学校保健学会 2011年11月 名古屋 第58回日本学校保健学会
  • 小面積におけるダニアレルゲン簡易測定の有用性の検討  [通常講演]
    中村晴信; 甲田 勝康; 藤田 裕規; 石川哲也; 小原久未子; 間瀬知紀; 宮脇千恵美; 桑原恵介; 川畑徹朗; 辻本悟史; 加藤佳子
    第58回日本学校保健学会 2011年11月 名古屋 第58回日本学校保健学会
  • 降圧薬と骨代謝指標の関連-藤原京スタディ男性骨折コホート研究の断面検討  [通常講演]
    玉置 淳子; 伊木 雅之; 藤田 裕規; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 冨岡公子; 岡本希; 車谷典男
    第13回日本骨粗鬆症学会 骨ドック・健診分科会 2011年11月 神戸 第13回日本骨粗鬆症学会 骨ドック・健診分科会
  • 社会経済的要因と骨密度との関連-藤原京スタディ男性骨粗鬆症コホート研究の断面検討-  [通常講演]
    文鐘聲; 伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 森川将行; 佐藤裕保; 冨岡公子; 岡本希; 車谷典男
    第70回日本公衆衛生学会総会 2011年10月 秋田 第70回日本公衆衛生学会総会
  • 乳幼児期の急速な体重増加がその後の心血管疾患リスク要因に及ぼす影響  [通常講演]
    藤田 裕規; 甲田 勝康; 伊木 雅之; 中村晴信
    第70回日本公衆衛生学会総会 2011年10月 秋田 第70回日本公衆衛生学会総会
  • 女子中学生における理想の体格と体組成の関係  [通常講演]
    小原久未子; 甲田 勝康; 藤田 裕規; 伊木 雅之; 中村晴信; 佐藤裕保; DongMei Namiraa
    第70回日本公衆衛生学会総会 2011年10月 秋田 第70回日本公衆衛生学会総会
  • 小学生におけるメディア使用時間と自覚症状との関連  [通常講演]
    中村晴信; 甲田 勝康; 藤田 裕規; 石川哲也; 西尾信宏; 小原久未子; 桑原恵介
    第70回日本公衆衛生学会総会 2011年10月 秋田 第70回日本公衆衛生学会総会
  • 日本人小学生における部位別体脂肪と血清コレステロールとの関係  [通常講演]
    甲田 勝康; 藤田 裕規; 伊木 雅之; 中村晴信
    第70回日本公衆衛生学会総会 2011年10月 秋田 第70回日本公衆衛生学会総会
  • GFR estimated with serum creatinine may be misleading in association between subclinical decline in renal function and bone mass in community-dwelling elderly men: FORMEN study  [通常講演]
    伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; Kadowaki E; Sato Y; Moon JS; Tomioka; K; Okamoto; N; Kurumatani N
    The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Minera 2011年05月 Athens The 3rd Joint Meeting of the European Calcified Tissue Society and the International Bone and Minera
  • 思春期・青年期の全身骨量と体脂肪量および除脂肪量の関係  [通常講演]
    甲田 勝康; 藤田 裕規; 伊木 雅之; 冬梅; 佐藤裕保
    第21回日本疫学会学術総会 2011年01月 札幌 第21回日本疫学会学術総会
  • 骨代謝における軽度・中等度腎機能低下の影響 ~藤原京スタディ男性骨粗鬆症コホート研究~  [通常講演]
    藤田 裕規; 伊木 雅之; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 冨岡公子; 岡本希; 車谷典男
    第21回日本疫学会学術総会 2011年01月 札幌 第21回日本疫学会学術総会
  • HMG-CoA還元酵素阻害剤は骨量低下を抑制するか-藤原京スタディ男性骨折コホート研究の断面検討  [通常講演]
    玉置 淳子; 伊木 雅之; 藤田 裕規; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 冨岡公子; 岡本希; 車谷典男
    第21回日本疫学会学術総会 2011年01月 札幌 第21回日本疫学会学術総会
  • An inverse association between serum undercarboxylated osteocalcin levels and blood glucose and hemoglobin A1c levels in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study  [通常講演]
    伊木 雅之; 玉置 淳子; 藤田 裕規; 甲田 勝康; Kadowaki E; Sato Y; Moon JS; Tomioka; K; Okamoto; N; Kurumatani N
    International Osteoporosis Foundation (IOF) Regionals-1st Asia Pacific Osteoporosis Meeting 2010年12月 Singapore International Osteoporosis Foundation (IOF) Regionals-1st Asia Pacific Osteoporosis Meeting
  • 高密度織物製寝具を用いたダニアレルゲン低減に関する試み  [通常講演]
    中村晴信; 甲田 勝康; 藤田 裕規; 石川哲也; 川畑徹朗; 辻本悟史; 桑原恵介; 間瀬知己; 小原久未子
    第57回日本学校保健学会 2010年11月 坂戸 第57回日本学校保健学会
  • 青少年期における摂食障害の一次予防  [通常講演]
    小原久未子; 甲田 勝康; 藤田 裕規; 中村晴信; 川畑徹朗; 辻本悟史; 石川哲也; 間瀬知己; 桑原恵介
    第57回日本学校保健学会 2010年11月 坂戸 第57回日本学校保健学会
  • 摂食障害の一次予防-発症要因や保護要因からの検討-  [通常講演]
    小原久未子; 甲田 勝康; 藤田 裕規; 中村晴信; 櫻井寿美; 桑原恵介
    第69回日本公衆衛生学会総会 2010年10月 東京 第69回日本公衆衛生学会総会
  • 乳幼児の体重獲得の時期とパターンが思春期の血清脂質に及ぼす影響  [通常講演]
    中村晴信; 藤田 裕規; 甲田 勝康; 伊木 雅之; 小原久未子
    第69回日本公衆衛生学会総会 2010年10月 東京 第69回日本公衆衛生学会総会
  • 乳幼児の体重獲得の時期とパターンが思春期の肥満に及ぼす影響  [通常講演]
    甲田 勝康; 藤田 裕規; 伊木 雅之; 中村晴信; 小原
    第69回日本公衆衛生学会総会 2010年10月 東京 第69回日本公衆衛生学会総会
  • 習慣的牛乳引用は男性高齢者でも骨密度に関連する-藤原京スタディ男性骨粗鬆症研究-  [通常講演]
    佐藤裕保; 伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 文鐘聲; 冨岡公子; 岡本希; 車谷典男
    第69回日本公衆衛生学会総会 2010年10月 東京 第69回日本公衆衛生学会総会
  • 高齢者における慢性腎臓病の有病状況と循環器リスク要因との関連-藤原京スタディ-  [通常講演]
    伊木 雅之; 玉置 淳子; 藤田 裕規; 甲田 勝康; 由良 晶子; 門脇英子; 冨岡公子; 岡本希; 車谷典男
    第69回日本公衆衛生学会総会 2010年10月 東京 第69回日本公衆衛生学会総会
  • 糖尿病患者の履物に対する意識調査  [通常講演]
    櫻井寿美; 甲田 勝康; 藤田 裕規; 中村晴信; 小原久未子; 桑原恵介
    第69回日本公衆衛生学会総会 2010年10月 東京 第69回日本公衆衛生学会総会
  • 日本人高齢男性では血清オステオカルシン濃度は空腹時血糖値,並びにヘモグロビンA1c値と逆相関する。藤原京スタディ男性骨粗鬆症(FORMEN)研究  [通常講演]
    伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 岡本希 車谷典男
    第28回日本骨代謝学会学術集会 2010年07月 東京 第28回日本骨代謝学会学術集会
  • Impact of smoking on bone mineral density in elderly men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study  [通常講演]
    玉置 淳子; 伊木 雅之; 藤田 裕規; 甲田 勝康; 由良 晶子; Kadowaki E; Sato Y; Moon JS; Tomioka; K; Okamoto; N; Kurumatani N
    Clinical Osteoporosis 2010: An ISCD-NOF Symposium 2010年03月 San Antonio Clinical Osteoporosis 2010: An ISCD-NOF Symposium
  • Validity of the cut-off values for waist circumference and waist-to-height ratio for schoolchildren  [通常講演]
    藤田 裕規; 甲田 勝康; 伊木 雅之; Nakamura H; Kuwahara K; Okamoto T
    The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region 2010年01月 Koshigaya The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region
  • Baseline data of a cohort study for determinants of osteoporotic fracture in community-dwelling elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study  [通常講演]
    伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; Kadowaki E; Sato Y; Moon JS; Morikawa M; Tomioka; K; Okamoto; N; Kurumatani N
    The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region 2010年01月 Koshigaya The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region
  • Associations of perceptions related to swine influenza and preventive behaviors against infection  [通常講演]
    Kuwahara K; 甲田 勝康; 藤田 裕規; Ishikawa T; Nakamura H; Shimai S
    The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region 2010年01月 Koshigaya The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region
  • 現在の体型に食行動とその関連要因が及ぼす影響-大学生における性差を考慮した検討-  [通常講演]
    桑原恵介; 甲田 勝康; 藤田 裕規; 石川哲也; 川畑徹朗; 藤宮正規; 増山隆太; 中村晴信; 島井哲志; 西尾信宏
    第56回日本学校保健学会 2009年11月 那覇市 第56回日本学校保健学会
  • 同一地域に在住する小・中学生のメディア使用の実態,および健康状態との関連  [通常講演]
    中村晴信; 甲田 勝康; 藤田 裕規; 石川哲也; 川畑徹朗; 桑原恵介; 西尾信宏
    第56回日本学校保健学会 2009年11月 那覇市 第56回日本学校保健学会
  • 母子健康手帳からみた小学生・中学生のBMI~大規模ポピュレーション研究~  [通常講演]
    藤田 裕規; 甲田 勝康; 伊木 雅之; 中村晴信; 桑原
    第56回日本学校保健学会 2009年11月 那覇市 第56回日本学校保健学会
  • メディア使用と健康状態との関連-同一地域に在住する小・中学生の調査から-  [通常講演]
    中村晴信; 甲田 勝康; 藤田 裕規; 石川哲也; 西尾信宏
    第68回日本公衆衛生学会総会 2009年10月 奈良 第68回日本公衆衛生学会総会
  • 捨て置かれし男性の骨を守ろう! 藤原京スタディ男性骨粗鬆症コホート研究の発進  [通常講演]
    伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 岡本希 車谷典男
    第68回日本公衆衛生学会総会 2009年10月 奈良 第68回日本公衆衛生学会総会
  • 納豆摂取による骨密度低下の予防効果~藤原京スタディ男性骨粗鬆症コホート研究~  [通常講演]
    藤田 裕規; 伊木 雅之; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 冨岡公子; 岡本希; 車谷典男
    第68回日本公衆衛生学会総会 2009年10月 奈良 第68回日本公衆衛生学会総会
  • 喫煙年数が長いほど骨密度は低い-藤原京スタディ男性骨粗鬆症コホート研究の断面検討  [通常講演]
    玉置 淳子; 伊木 雅之; 藤田 裕規; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 冨岡公子; 岡本希; 車谷典男
    第68回日本公衆衛生学会総会 2009年10月 奈良 第68回日本公衆衛生学会総会
  • 適度な飲酒は骨粗鬆症を防ぐ-藤原京スタディ男性骨粗鬆症コホート研究-  [通常講演]
    甲田 勝康; 伊木 雅之; 藤田 裕規; 玉置 淳子; 由良 晶子; 佐藤裕保; 文鐘聲; 森川将行; 冨岡公子; 岡本希; 車谷典男
    第68回日本公衆衛生学会総会 2009年10月 奈良 第68回日本公衆衛生学会総会
  • 藤原京スタディ男性骨粗鬆症コホート研究の発進  [通常講演]
    伊木 雅之; 藤田 裕規; 玉置 淳子; 甲田 勝康; 由良 晶子; 門脇英子; 佐藤裕保; 文鐘聲; 岡本希 車谷典男
    第11回日本骨粗鬆症学会 骨ドック・健診分科会 2009年10月 名古屋 第11回日本骨粗鬆症学会 骨ドック・健診分科会
  • Body weight at age 1.5 and 3 years affects bone mass of Japanese adolescents but birth weight dose not: Shiokawa Kids Bone Health Study  [通常講演]
    伊木 雅之; 玉置 淳子; 藤田 裕規; 甲田 勝康; Kadowaki E; Ikeda Y; Sato Y; Morita A; Kajita E
    5th International Conference on Children's Bone Health 2009年06月 Cambridge 5th International Conference on Children's Bone Health
  • 思春期児童における腹囲/身長比の肥満指標としての意義  [通常講演]
    藤田 裕規; 甲田 勝康; 伊木 雅之; 中村晴信; 岡本敏子
    第19回日本疫学会学術総会 2009年01月 金沢 第19回日本疫学会学術総会
  • ゲームやパソコン・携帯メールと思春期の体格や血清脂質との関係  [通常講演]
    甲田 勝康; 藤田 裕規; 由良 晶子; 伊木 雅之; 中村晴信
    第67回日本公衆衛生学会総会 2008年11月 福岡 第67回日本公衆衛生学会総会
  • Relationships between blood pressure and height among Japanese schoolchildren: population-based followup study  [通常講演]
    甲田 勝康; 藤田 裕規; 伊木 雅之; Nakamura H; Nishio N; Takeuchi H
    9th International Congress of Physiological Anthropology 2008年08月 Delft 9th International Congress of Physiological Anthropology
  • 小児の身長と血圧:ポピュレーションベースの追跡研究  [通常講演]
    甲田 勝康; 藤田 裕規; 由良 晶子; 伊木 雅之; 中村晴信; 西尾信宏; 竹内宏一
    第18回日本疫学会学術総会 2008年01月 東京 第18回日本疫学会学術総会
  • 思春期の体格,血清脂質,血圧:ポピュレーションベースの追跡研究  [通常講演]
    甲田 勝康; 由良 晶子; 藤田 裕規; 伊木 雅之; 中村晴信; 西尾信宏
    第66回日本公衆衛生学会総会 2007年10月 愛媛 第66回日本公衆衛生学会総会
  • ヒト・グリオーマ細胞におけるH-ras(V12)発現による液胞化・細胞死へのリソソーム・エンドソームの関与について  [通常講演]
    藤田 裕規; 藤田 英明; 姫野 勝; 北中 千史; 口野 嘉幸
    日本薬学会年会要旨集 1999年03月 (公社)日本薬学会

MISC

受賞

  • 2015年09月 日本骨粗鬆症学会 第17回優秀演題賞
     
    受賞者: 藤田 裕規
  • 2010年10月 日本骨粗鬆症学会 2010年度研究奨励賞
  • 2009年10月 第68回日本公衆衛生学会総会 優秀演題賞

共同研究・競争的資金等の研究課題

  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2020年04月 -2024年03月 
    代表者 : 中村 晴信; 甲田 勝康; 藤田 裕規; 小原 久未子
     
    成長期の食行動は体格の形成や生活習慣病の予防にとって重要であるが、その行動変容を行うには困難を伴う。また、単純に体重を指標とした行動変容では、やせ願望と結びつき、やせや摂食障害等のリスクを伴うこともある。一方、体組成を構成する骨・筋・脂肪の量や分布を知り、自分の 発育状態が把握できると、体組成を適切に保持するための食行動は何が必要かということがより明確となり、適切な食行動変容の促進につながることが考えられる。従って、本研究では、正確な体組成測定による骨・筋・脂肪の量や分布を児童・生徒が把握することにより食行動変容にもたらす影響を明らかにすることを目的とする。 令和3年度は、令和2年度と同様に、兵庫県姫路市の小学生約140名を対象に、身長・体重測定、腹囲測定、二重エネルギーエックス線吸収測定法(DXA法)による体組成測定、マルチ周波数を使ったインピーダンス法による体組成測定、血圧測定、および質問紙調査を行った。また、本年度より立ち上がり・しゃがみ込み動作による運動機能測定を実施し、質問紙による運動量測定と合わせて身体活動に関する評価を行った。これらの測定の結果、筋肉量は運動とある程度の関連はみられるものの、体重との関連もみられ、これら双方の関係性に違いがあるかどうかについては、単に筋量のみならず筋質も評価することにより、その相違を明らかにする必要が生じた。これを受け、次年度より、筋の量だけでなく質を測定するために、新たに超音波測定装置を導入し、次年度以降に実施を予定している、超音波測定装置による筋質測定のための手技の確立に努めた。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2020年04月 -2024年03月 
    代表者 : 藤田 裕規; 伊木 雅之; 甲田 勝康
     
    これまでに、in vivo実験においてC1q/tumor necrosis factor (TNF)-related Protein 3 (CTRP3)には、破骨細胞分化誘導因子誘導性の破骨細胞形成と骨破壊を低下させる働きがあることが報告され、骨粗しょう症の予防や治療に有用な新たな物質であることが期待される。そこで、申請者らは、血清CTRP3低値が骨粗しょう症、脆弱性骨折の発症リスクを高めるかを縦断的に検討することを目的とした。申請者らは、2007年から男性2174人を対象に前向きコホート研究を実施している。2007年と2008年にはベースライン研究を実施し、2012人が調査を完遂している。このベースライン研究の際に参加者から血清を得て、凍結保存している。2020年度には、この凍結保存血清を用いて、1095検体で測定が完了した。2021年度には、2020年度に未測定であったの凍結保存血清を用いて、156検体で測定を完了した。測定は、2020年度と同様にELISA法(Enzyme-Linked Immuno Sorbent Assay:酵素結合免疫吸着検定法)により行った。119.2±293.2 ng/mlであった。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2019年04月 -2023年03月 
    代表者 : 甲田 勝康; 中村 晴信; 藤田 裕規; 伊木 雅之
     
    内臓脂肪の蓄積は、アディポサイトカイン等の生理活性物質を介して、臓器機能障害を伴うことが多い。一方、皮下脂肪の減少は高中性脂肪血症や肝臓や骨格筋など異所性脂肪の蓄積による臓器機能障害を引き起こすことが指摘されている。つまり、脂肪の量だけでなく存在部位にも目を向ける必要がある。DXA法は体幹部脂肪(内臓脂肪と皮下脂肪)と四肢脂肪(皮下脂肪)を部位別に精密に測定する方法で、体脂肪の分布状態が評価できる。 本研究組織では、2007年から芽室、喜多方、西会津、上越、三島、袋井、浜松、奈良、橿原、香芝、淡路、姫路、讃岐、宮古島において、DXA法を用いた疫学調査を行っており、小児から高齢者7000名以上の体脂肪分布に関するデータを蓄積している。また、調査試料には凍結血清も含まれており、一部は関西医科大学の超低温冷凍庫で保管されている。 本研究課題でも2019年度から2021年度にかけて、DXA法を用いた疫学調査を各地で行い、新たに体脂肪分布に関する試料・情報を蓄積した。2021年度は全国で新型コロナウイルスが蔓延し、疫学調査の実施が困難であったが、調査対象となる姫路市立小学校の十分な協力体制の下でDXA法による部位別体脂肪測定調査を実施することができた。同時に、2019年度に実施した奈良県在住男性高齢者調査(Fujiwarakyo Osteoporosis Risk in Men study:FORMEN study)のデータを用いて体脂肪分布と腎機能について解析を行い、その結果、両者の間に関連性がみとめられることが新たに示唆された。さらに、HMGB1、Irisin、TNF-a、IL-6についてELISAを用いて保存血清中の濃度測定を開始した。 なお本研究は、近畿大学医学部倫理委員会および関西医科大学倫理審査委員会の承認に基づいて実施された。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2018年04月 -2023年03月 
    代表者 : 立木 隆広; 伊木 雅之; 甲田 勝康; 藤田 裕規; 北川 淳
     
    本研究の目的は、日本人男性の大規模コホートを用いて、下肢筋量低下が骨折リスクの増大に関連するかどうかを明らかにし、下肢筋量に着目した骨折リスク評価モデルの開発を行うことである。本研究は、Fujiwara-kyo osteoporosis risk in men (FORMEN) 研究の10年次追跡調査に、新たに下肢筋量の評価を加えBaselineとし、その後3年間の骨折発生を追跡する前向きコホート研究である。10年次追跡調査では、本研究に必要な情報を収集している。平成30年度は、FORMEN研究の対象地域のうち、奈良県橿原市、奈良市、香芝市で在住の対象者について、10年次追跡調査を以下の内容で実施した。 (1)受診者数と受診率:受診者数は橿原市318人、奈良市146人、香芝市25人、受診率は橿原市44.2%、奈良市41.0%、香芝市47.5%であった。(2)下肢筋量の測定:Hologic社製QDR4500A車載型を用い、二重エネルギーX線吸収法で全身スキャンを行った。頭部、体幹、上肢、下肢等の各部位別の筋量を測定できる体組成解析ソフトウェアAPEX Ver2.3を用いて下肢筋量を測定した。(3)症候的骨折の把握:症候的骨折は問診で把握した。症候的骨折は、「痛みを伴い、医療機関でレントゲン撮影を受けて医師によって診断された骨折」と定義した。(4)運動機能の測定:筋力(握力、5回立ち座りテスト)、 歩行能力(歩行速度)、 静的バランス能力(開眼片脚立ち)を測定した。上記以外で本研究に必要な情報も収集した。 本年度の受診者は、本来目標としていた受診者数を下回る結果となった。このため令和元年度に新たに対象者を募集する。したがって、本研究のBaseline調査を平成30年度と令和元年の2年間として、その後骨折の発生を追跡することにする。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2018年04月 -2021年03月 
    代表者 : 玉置 淳子; 久藤 麻子; 林 江美; 千葉 康敬; 神谷 訓康; 伊木 雅之; 藤田 裕規; 上西 一弘; 顧 艶紅; 新田 明美; 池原 賢代
     
    FORMEN研究10年次追跡調査を2018年11月、2019年2-3月に実施した。追跡調査受診者577人(11月318人、2-3月259人)の追跡時データを得た。以下の具体的な追跡時収集し得たデータを示す。 脳心血管疾患発生の把握及び動脈硬化指標の測定 現病歴及び問診票を用いて脳卒中発症候補者を把握した。動脈硬化指標としては、頸動脈内膜中膜複合体厚(IMT)値を測定し、プラークの性状を評価した。同一検者による測定を実施し、すべての画像について申請者が確認し、適宜画像上の再測定を行い測定値を確定した。上腕足関節脈波伝播速度(PWV)・足関節上腕血圧比(ABI)の測定についても同一検者による測定を実施した。 症候的骨折の把握 症候的骨折は「痛みを伴い、医療 機関でX線撮影を受けて医師によって診断された骨折」として質問票による回答を専任のスタッフが確認・補完した。 胸腰椎のデジタル画像撮影と椎体骨折の診断 Hologic社QDR4500A車載型を用い、単一エネルギーX線吸収法にて胸腰椎側面のデジタル画像撮影を行い、現有のHologic社製骨形態計測ソフトウェアを使用し椎体高を測定した。 古典的循環器疾患リスク要因の把握 古典的循環器疾患リスク要因の把握については、身長・体重・腹囲、血圧の測定、生化学的血液検査、問診票による喫煙、飲酒習慣に関する情報収集を行った。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2018年06月 -2020年03月 
    代表者 : 伊木 雅之; 藤田 裕規; 立木 隆広; 由良 晶子
     
    ①JPOSコホート研究の参加者の内、40歳以上女性約2000人とFORMENコホート研究の参加者で、65歳以上の男性約2000人を対象に、②主要アウトカムである大腿骨近位部骨折と副次的アウトカムである全骨粗鬆症性臨床骨折と椎体骨折の発生を捉え、③Baselineの大腿骨近位部DXA画像を新たに開発された大腿骨近位部三次元構造解析ソフトウェアで解析し、大腿骨近位部各部位の海綿骨体積骨密度、皮質骨体積骨密度、平均皮質骨厚等の三次元構造指標を求め、④それによる骨折リスクの予測性能を評価する。 ②の内、JPOSコホートについては20年間の追跡調査が完了しており、その間のアウトカムの発生状況を整理し、分析できたのは1753人で、大腿骨近位部骨折は40人、全骨粗鬆症性臨床骨折は230人に、椎体骨折は脊椎画像が評価できた1872人中、145人に確認された。FORMENコホートについては③が進捗しなかったため、本研究担当分については平成31年度に繰り延べている。 ③は本研究の核心となる部分である。本ソフトウェアで基準としている大腿骨近位部構造モデルはフランス人から得られたQCT画像に基づいており、当初からフランス人と日本人の体格の違いが結果に影響する可能性が考えられた。そこで、JPOSコホートの中からDXAで測定された体厚の薄い者10名と厚い者10名、並びに身長の低い者10名を抽出し、その画像を同ソフトで解析する確認作業を実施した。その結果、構造モデルのパラメーターの一部に修正が必要となり、それが終わるのに時間を要した。万一、体格の小さい日本人には適用できないとなると本研究が遂行できなくなるので、研究費の返還を念頭に置き、構造モデルのパラメーターの修正が完了するまではできるだけ研究費の執行を控えるため、予定していた調査を翌年度に繰り延べることとした。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2017年04月 -2020年03月 
    代表者 : 由良 晶子; 伊木 雅之; 藤田 裕規
     
    FORMENコホート研究10年次追跡調査を奈良県橿原市、香芝市、奈良市、大和郡山市の対象者約1000人について実施した。内容は予定通りで、(1) 対象者に空腹(食後7時間以上)での受診を求め、静脈血を採取し、血漿中グルコース濃度(FPG)とヘモグロビンA1c (HbA1c)の存在割合を測定した。この検査と問診時に処方箋かお薬手帳で糖尿病の現在の治療の有無を確認し、糖尿病新規発症を判定した。糖尿病新規発症の定義は、Baselineで糖尿病治療の既往がなかった者で、上記検査が空腹時血糖126 mg/dl以上、または、HbA1c 6.5%以上か、糖尿病の治療歴が生じた場合とした。(2) インスリン抵抗性はFPGと血清インスリン濃度からhomeostatic model assessment insulin resistance (HOMA-IR)を算出し、評価した。(3)二重エネルギー吸収法による体組成測定から部位別の体脂肪量と体脂肪率を算出した。(4)メタボリック症候群はウエスト周囲長、血清トリグリセライド濃度、血圧、FPG濃度より診断した。 受診者は489人で、高齢者の10年間の追跡調査としては許容できる範囲と考えられた。受診者については空腹時血糖とHbA1c値により糖尿病の新規発生を把握し、二重エネルギー吸収法による体脂肪量の測定も問題なく、全員に実施できた。各種測定結果からインスリン抵抗性の指標であるHOMA-IRを推定し、メタボリック症候群の診断も実施できた。 現在、得られたデータは順次電子化し、データベースを作成中である。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2015年04月 -2020年03月 
    代表者 : 伊木 雅之; 佐藤 裕保; 藤田 裕規; 立木 隆広; 上西 一弘; 梶田 悦子; 文 鐘聲; 甲田 勝康; 由良 晶子; 北川 淳; 玉置 淳子; 岡本 希
     
    FORMENコホート研究10年次追跡調査を奈良県橿原市、香芝市、奈良市、大和郡山市の対象者約1000人について実施した。内容は予定通りで、(1) 対象者に空腹(食後7時間以上)での受診を求め、静脈血を採取し、血漿中グルコース濃度(FPG)とヘモグロビンA1c (HbA1c)の存在割合を測定した。この検査と問診時に処方箋かお薬手帳で糖尿病の現在の治療の有無を確認し、糖尿病新規発症を判定した。糖尿病新規発症の定義は、Baselineで糖尿病治療の既往がなかった者で、上記検査が空腹時血糖126 mg/dl以上、または、HbA1c 6.5%以上か、糖尿病の治療歴が生じた場合とした。(2) インスリン抵抗性はFPGと血清インスリン濃度からhomeo static model assessment insulin resistance (HOMA-IR)を算出し、評価した。(3)二重エネルギー吸収法による体組成測定から部位別の体脂肪量と体脂肪率を算出した。(4)メタボリック症候群はウエスト周囲長、血清トリグリセライド濃度、血圧、FPG濃度より診断した。 受診者は489人で、高齢者の10年間の追跡調査としては許容できる範囲と考えられた。受診者については空腹時血糖とHbA1c値により糖尿病の新規発生を把握し、二重エネルギー吸収法による体脂肪量の測定も問題なく、全員に実施できた。各種測定結果からインスリン抵抗性の指標であるHOMA-IRを推定し、メタボリック症候群の診断も実施できた。 現在、得られたデータは順次電子化し、データベースを作成中である。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2014年04月 -2018年03月 
    代表者 : 甲田 勝康; 中村 晴信; 藤田 裕規; 伊木 雅之
     
    二重エネルギーX線吸収法(DXA法)では、脂肪量を上肢、下肢、体幹部などの部位別に測定することができ、DXA法による体幹・下肢脂肪比(TLR)や体幹・四肢脂肪比(TAR)は体脂肪分布の指標である。本研究課題では、地域在住の小児を追跡し、DXA法による体脂肪分布(TLR や TAR)と代謝循環機能について検討した。その結果、小児期の体脂肪分布の状態は発育の程度や母親を中心とした生活習慣に影響を受ける事が示唆された。さらに、体脂肪分布は糖・脂質代謝機能や循環器機能に影響を及ぼす可能性が示唆された。体脂肪分布は代謝循環疾患のリスクの評価に追加情報を付加するものではないかと考えられた。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2015年04月 -2017年03月 
    代表者 : 藤田 裕規; 甲田 勝康; 中村 晴信; 伊木 雅之
     
    本研究の目的は、味覚と二重エネルギーX線吸収法によって測定した体組成との関係を検討することである。4歳(年中)から5歳(年長)の1年間で、味覚の検知能力の発達はみられなかったが、識別能力は発達がみられた。味覚の検知スコアを総合的にみると、体脂肪指数が高いグループほど優れていた。しかしながら、味覚識別能力と体脂肪との関係はみられなかった。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2014年04月 -2017年03月 
    代表者 : 由良 晶子; 藤田 裕規; 伊木 雅之
     
    骨粗鬆症対策は検診が女性に限定される等、男性は捨て置かれている。そこで、WHOの骨折リスク予測モデルFRAXが日本人男性に適用できるかと椎体骨折を予測できるかを検討した。 男性1805人を5年間追跡し、主要骨粗鬆症性骨折と椎体骨折を把握し、FRAXによる骨折確率等で骨折を予測するモデルを作成した。FRAXによる主要骨粗鬆症性骨折予測のROC曲線下面積は0.668で、FRAXが作成されたコホートでの値を上回った。椎体骨折予測の曲線下面積は0.628だったが、腰椎骨密度、年齢、BMIでより高い性能となった。FRAXは主要骨粗鬆症性骨折予測では有効だったが、椎体骨折では腰椎骨密度に及ばなかった。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2012年04月 -2016年03月 
    代表者 : 中村 晴信; 甲田 勝康; 藤田 裕規; 間瀬 知紀; 小原 久未子
     
    男子においては、小学生で骨量および筋肉量と睡眠時間との間に負の相関関係が、中学生で骨量と筋肉量と就寝時刻との間に正の相関が得られた。女子においては、小学生で筋肉量と睡眠時間との間に負の相関が、中学生で就寝時刻と体重・body mass index・骨量・腹囲と正の相関が、起床時刻と身長・体重・骨量・腹囲との間に正の相関が得られた。このことから、生活リズムに関する項目については、体組成との間で関連性がみられた。また、ビタミンDやアディポネクチンと体組成との間に関係がみられ、骨型酒石酸抵抗性酸性フォスファターゼやⅠ型コラーゲンC末端テロペプチドと骨量および骨密度との間に関係がみられた。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2013年04月 -2015年03月 
    代表者 : 中村 晴信; 甲田 勝康; 藤田 裕規; 古谷 真樹; 小原 久未子
     
    男子においては、小学生で骨量および筋肉量と睡眠時間との間に負の相関関係が、中学生で骨量と筋肉量と就寝時刻との間に正の相関が得られた。女子においては、小学生で筋肉量と睡眠時間との間に負の相関が、中学生で就寝時刻と体重・body mass index・骨量・腹囲と正の相関が、起床時刻と身長・体重・骨量・腹囲との間に正の相関が得られた。このことから、生活習慣の中でも、睡眠や就寝時刻や起床時刻等の生活リズムに関する項目については、体組成との間で関連性がみられた。加えて、男子と女子の間には、有意な相関関係がみられた項目の種類や数に違いが見られた。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2013年04月 -2015年03月 
    代表者 : 甲田 勝康; 中村 晴信; 藤田 裕規; 伊木 雅之
     
    LDLやHDLコレステロールは粒子サイズに応じてさらに亜分画に分けることができる。一方、二重エネルギーX線吸収法(DXA法)は体脂肪の量と分布を正確に測定する方法である。本研究ではDXAで測定した体脂肪の量と分布様式と脂質亜分画について検討した。HDLコレステロールの亜分画であるlarge HDLコレステロールは体脂肪の量と分布と共に負の関連性を示した。一方、small HDLコレステロールは体脂肪(量と分布共に)と正の関連性を示した。HDLコレステロールはその亜分画の種類によっては体脂肪の量や分布と関係性が異なることが示された。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2013年04月 -2015年03月 
    代表者 : 藤田 裕規
     
    ベースライン調査時に骨密度が低い者(Tスコアが-2.5未満)において、新規の骨粗鬆症性骨折を起こした群では起こさなかった群に比べ、終末糖化物質(ペントシジン)は有意に高い値を示し、終末糖化物質の特異的受容体は有意に低い値を示した。また、ペントシジンの上昇は、糖尿病や腎機能の低下と関係していることが示された。このように、終末糖化物質濃度の上昇あるいはその受容体濃度の低下は骨折を予測する因子である可能性が示唆された。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2012年04月 -2015年03月 
    代表者 : 伊木 雅之; 車谷 典男; 玉置 淳子; 藤田 裕規; 佐藤 裕保
     
    藤原京スタディ男性骨粗鬆症研究参加者を5年追跡して新規骨折を把握し、骨折リスク評価モデルFRAXの有用性を確認し、骨折と死亡、心血管疾患との関連を検討した。 主要骨粗鬆症性骨折(MOF)をFRAXの予測確率で予測した場合のROC曲線下面積は0.681だった。新規骨折は死亡のリスクをfrailty indicesを調整しても2.75倍に上げた。MOFを起こすとdefinite anginaのリスクが2.9倍になった。 日本人男性においてもFRAXはある程度の骨折予測性能を持つが、改良の余地があった。骨折は死亡のリスクを上げ、その一部は虚血性心疾患である可能性が示唆された。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2010年04月 -2014年03月 
    代表者 : 甲田 勝康; 中村 晴信; 藤田 裕規; 伊木 雅之
     
    Kinki Kobe Body Composition Study (KKBC Study) では以前から、学校等に全身型二重エネルギーX線吸収法測定装置搭載バスを持ち込んで、全身骨塩量、全身脂肪量や除脂肪軟部組織量の測定を行っている。本研究課題ではKKBC Study集団において、環境要因と骨量獲得および骨代謝に及ぼす影響について検討した。その結果、成長期の骨量の増加ペースに男女差がある事、骨量獲得には、脂肪量よりも除脂肪軟部組織量が強く影響する事、母親を中心とした家庭環境が影響する事等が明らかとなった。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2009年 -2011年 
    代表者 : 伊木 雅之; 車谷 典男; 玉置 淳子; 藤田 裕規; 佐藤 裕保
     
    地域在住男性高齢者2159人を2011年3月末まで追跡し、骨折のリスク要因を把握すると共に、生存期間への骨折、循環器リスク要因、糖尿病等の影響を評価した。その結果、骨折の予測要因は低骨密度、死亡のそれは加齢、高感度CRP高値、骨折で、中でも骨折は骨折無しを基準に年齢調整ハザード比17.9、多変量調整後も12.9となった。高齢日本人男性では骨折は極めて重要な死亡のリスク要因であった。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2009年 -2010年 
    代表者 : 甲田 勝康; 伊木 雅之; 中村 晴信; 藤田 裕規
     
    成長がコレステロール代謝に影響することが報告されている。成長や体格の多型を詳細に検討するためには体組成の正確な把握が重要である。体組成は骨・筋肉・脂肪に分類できる。二重エネルギーX線吸収法(DXA法)は2種類の異なるX線エネルギーを使用することで骨と軟部組織とを判別し、全身の体組成を正確に測定する事ができる。今回の目的は、第二次性徴期に着目し、DXA法で測定した体組成を分析し、体組成と血清コレステロールの多型を探ることである。全身型DXA測定装置搭載バスを学校に持ち込んで体組成の測定を行うと共に、高密度リポタンパクコレステロール(HDLC)および低密度リポタンパクコレステロール(LDLC)の測定を行なった。対象は文書で同意が得られた浜松市の小学5年生216名であった。研究計画は近畿大学医学部倫理委員会の承認を得て行った。体組成測定にはHologic社製QDR4500Aを用いた。骨・筋肉・脂肪のそれぞれの量は身長と正の相関がみとめられたため、体組成を身長の2乗で割る指標(Bone mass index, BOMI ; Fat mass index, FMI ; Skeletal mass index, SMI ; kg/m^2)を分析に用いた。その結果、HDLCは、男女共にFMIと負の関係がみられ、SMIとも負の関係がみられた。また、HDLCが高値を示す者はBOMIが低い傾向をみとめた。LDLCは、男子においてにFMIと正の関係がみられた。血清コレステロール値は体組成の発達と関連していることが示唆された。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2008年 -2010年 
    代表者 : 玉置 淳子; 伊木 雅之; 藤田 裕規
     
    2008年に65歳以上男性2182人についてFORMEN研究のベースライン調査を実施し、骨代謝指標等の測定を完了しデータベース化した。体格、喫煙等の骨折臨床的リスク要因と骨量低下との関連を明らかにした。また、ベースライン時の椎体骨折判定を2012人について完了した。これまでに29名の症候的骨折発生を確認できたが十分数ではなく、2012年の5年追跡にて骨折リスク評価モデルの構築の完成を行う。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2008年 -2010年 
    代表者 : 藤田 裕規
     
    血清低カルボキシル化オステオカルシン(ucOC)濃度が高い者は、低骨密度(若年成人平均値の1標準偏差以下)であるオッズ比が有意に高かった。症候的骨折を発生した者はベースライン時の骨密度が有意に低い値であり、低外力性骨折者はベースライン時の血清ucOC濃度が非骨折者よりも有意に高い値を示した。このように、血清ucOC濃度の上昇は骨折を予測する指標となる可能性が示唆された。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2007年 -2008年 
    代表者 : 甲田 勝康; 伊木 雅之; 中村 晴信; 藤田 裕規
     
    交通機関の発達、情報通信の発達、テレビやビデオゲームの登場など、社会の急激な変化によって小児肥満が増えている。肥満は体内に一定以上の脂肪が蓄積した状態と定義される。最近、二重エネルギーX線吸収法(DXA)による正確な体脂肪測定が可能となったが、小児の体脂肪量のデータは希少である。 平成20年度は平成19年度に引き続き、DXA法による体脂肪測定装置(Hologic社QDR4500A)搭載バスを静岡県袋井市内の保健センターと静岡県浜松市立の小学校に持ち込み、小学5年生児童の体組成の測定を実施した。その結果、小学5年生児童の体脂肪の基準値を求めるためのデータを得ることができ、さらに、小学5年生児童の筋肉量や骨量についても検討できた。 測定に先立って、児童の生活習慣、母親の妊娠中の栄養状態、幼児期の栄養状態についてアンケート調査を行った。その結果、骨量や筋肉量や体脂肪量が食習慣や生活習慣とさまざまに関連していることが示された。また、小学5年生児童の体組成と、その子どもが出生した当時の母親の体型や、その子どもの幼児期の体型との関係がみられた。このことから、小児の肥満予防には妊娠前後の母親教育も含めた、より早期の予防対策が必要であると考えられた。また、骨量も新体力テストの成績に関係があることが示され、骨粗しょう症の予防からも、この時期の体力づくりの必要性が示唆された。 本研究は近畿大学医学部倫理委員会の承認のもとに実施され、平成20年度研究は当初の目的および計画を変更することなしに終了した。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2004年 -2006年 
    代表者 : 石原 陽子; 萩原 啓美; 富田 幸子; 小久保 博樹; 坂田 律; 藤田 裕規
     
    本研究では、環境中ナノ粒子の健康影響評価においての分子生物学的手法の有用性(妥当性)を明確にすることを目的とした。 心肺組織は、7ヶ月間ディーゼル粒子に曝露した加齢ラットと3日間大気中濃縮粒子状物質(CAPs)に曝露された加齢ラットから採取された。DNAプロファイル分析でDNA遺伝子発現の増加が認められたものは、ディーゼル粒子曝露では補体、マクロファージ活性化サイトカイン、ケモカイン、CINC-2,ヘモキシゲナーゼ、アンジオテンシンII受容体、CAPs曝露肺では、補体、血液凝固関連因子が、CAPs曝露心組織では、補体であった。DNA発現の増加とそれらの蛋白濃度やmRNA発現とは必ずしも一致しなかった。ディーゼル又はCAPs曝露の加齢ラットのDNAレベルでの変動と生理的、病理学的所見やmRNA発現の程度には、弱い関連性を認めたに過ぎなかった。 一方、炎症関連サイトカインmRNAは、有機溶媒処理ディーゼル粒子処理ラット肺で非処理群と比較してより高い発現を示していた。単位重量当たりの粒子表面積を比較した場合、E-DEPはDEPと比較してより大であった。この事象は、肺ではナノ粒子が微粒子より強い毒性を発現しているという仮説を裏付けていた。 本研究から、DNAプロファイル分析はナノ粒子健康影響評価の初期段階で疾病関連バイオマーカーの選択に有用であり、バイオマーカーの選択後、これらのバイオマーカーのmRNA発現や蛋白濃度が確認され、最終的なナノ粒子毒性の健康影響評価は、分子生物学的成績に生化学的、血液学的、病理学的、生理学的データに加えてを総括して評価されるべきであることが示唆された。
  • 日本学術振興会:科学研究費助成事業
    研究期間 : 2002年 -2003年 
    代表者 : 福田 勝洋; 坂田 律; 荻本 逸郎; 柴田 彰; 黒沢 洋一; 能勢 隆之; 鈴木 宏; 藤田 裕規
     
    地域住民約11万名に関する生活習慣等を観察後,約10年間に446名が肝癌で死亡した.性,年齢,肝疾患既往(LD)歴,輸血摩,飲酒習慣,喫煙習慣,食事制限を交絡要因として,暴露要因糖尿病既往歴の原発性肝癌死ハザード比(HR)をCox法で算出すると,40-59歳群で2.95^*で有意(以下^*で表示)となったが,60-79歳群では有意ではなかった.飲酒習慣は,飲酒経歴の有無で2分割後,飲酒経歴のある者を飲酒頻度と飲酒中止時期とで更に6区分し,各飲酒習慣範疇を暴露要因として,肝疾患既往歴のない者について同様に解析した結果,高頻度飲酒者で早期(中止年齢55歳未満)に飲酒を中止した者のHRは6.0^*となった.食品摂取頻度項目に関する主成分分析の結果,野菜果物群,あるいは肉類群を反映する主成分の存在が示唆された.446名中血清情報が得られC型肝炎ウイルス抗体陽性の58名を症例とし,コーホート内でC型肝炎ウイルス抗体陽性状態,地域(道府県),性,年齢(±3)で対応した非肝癌死対照からなる58組の症例対照組を作り,ロジスチック回帰分析を行った結果,喫煙歴の輸血歴・LD歴・飲酒習慣調整原発性肝癌死オッズ比(OR)は喫煙者6.5^*,;α-fetoprotein高値(10ng/ml<)のLD歴調整ORは12.4^*;ferritin高値(男250<;女80ng/ml<)のLD歴調整ORは2.1となった.

委員歴

  • 2023年06月 - 現在   日本疫学会   代議員
  • 2019年04月 - 現在   日本生理人類学会   代議員
  • 2012年04月 - 現在   近畿学校保健学会   評議員
  • 2020年04月 - 2024年03月   日本衛生学会   編集委員会 委員
  • 2018年08月 - 2020年12月   大阪狭山市食育推進計画策定委員会   委員

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