- The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol., Nakamura K, Takachi R, Kitamura K, Saito T, Kobayashi R, Oshiki R, Watanabe Y, Kabasawa K, Takahashi A, Tsugane S, Iki M, Sasaki A, Yamazaki O, Environmental health and preventive medicine, Environmental health and preventive medicine, 23, 1, 28, 2018年06月, 査読有り
- Relationship Between Maternal Pre-pregnancy Weight and Offspring Weight Strengthens as Children Develop: A Population-Based Retrospective Cohort Study., Fujita Y, Kouda K, Nakamura H, Iki M, Journal of epidemiology, Journal of epidemiology, 2018年05月, 査読有り
- Fat mass is positively associated with bone mass acquisition in children with small or normal lean mass: A three-year follow-up study., Kouda K, Ohara K, Nakamura H, Fujita Y, Jaalkhorol M, Iki M, Bone, Bone, 107, 222, 227, 2018年02月, 査読有り
- Relationships between serum leptin levels and bone mineral parameters in school-aged children: a 3-year follow-up study., Kouda K, Ohara K, Fujita Y, Nakamura H, Tachiki T, Iki M, Journal of bone and mineral metabolism, Journal of bone and mineral metabolism, 2018年02月, 査読有り
- Does Trabecular Bone Score (TBS) improve the predictive ability of FRAX® for major osteoporotic fractures according to the Japanese Population-Based Osteoporosis (JPOS) cohort study?, Tamaki J, Iki M, Sato Y, Winzenrieth R, Kajita E, Kagamimori S, JPOS Study Group, Journal of bone and mineral metabolism, Journal of bone and mineral metabolism, 2018年02月, 査読有り
- Ratio of Endogenous Secretory Receptor for Advanced Glycation End Products to Pentosidine Predicts Fractures in Men., Tamaki J, Kouda K, Fujita Y, Iki M, Yura A, Miura M, Sato Y, Okamoto N, Kurumatani N, The Journal of clinical endocrinology and metabolism, The Journal of clinical endocrinology and metabolism, 103, 1, 85, 94, 2018年01月, 査読有り
- Hyperglycemia is associated with increased bone mineral density and decreased trabecular bone score in elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) study, Masayuki Iki, Yuki Fujita, Katsuyasu Kouda, Akiko Yura, Takahiro Tachiki, Junko Tamaki, Renaud Winzenrieth, Yuho Sato, Jong-Seong Moon, Nozomi Okamoto, Norio Kurumatani, BONE, BONE, 105, 18, 25, 2017年12月, 査読有り
概要：Purpose: Patients with type 2 diabetes mellitus (T2DM) have an increased fracture risk despite having higher areal bone mineral density (aBMD). This study aimed to clarify the association between glycemic and insulin resistance status and bone microarchitecture, and whether pentosidine and bone turnover markers play any roles in the association.
Methods: A total of 2012 community-dwelling men aged 65 years completed baseline measurements of spine aBMD, fasting plasma glucose (FPG) and serum insulin, hemoglobin A1c (HbA1c), osteocalcin, type I procollagen N-terminal propeptide, type I collagen C-terminal crosslinking telopeptide, tartrate-resistant acid phosphatase isoenzyme 5b, pentosidine, height and weight and an interview regarding past disease history. Homeostasis model assessment-insulin resistance (HOMA-IR) was also calculated. T2DM was defined as physician-diagnosed middle age or elderly-onset diabetes mellitus, or according to biochemical test results. To evaluate bone microarchitecture, trabecular bone score (TBS) was calculated at the same vertebrae as those used for aBMD measurement.
Results: After excluding participants who had a disease history and/or were taking medications affecting bone metabolism, 1683 men (age, 72.9 +/- 5.2 years) were analyzed. Men with T2DM had significantly higher aBMD compared to those without T2DM. There was no significant difference in TBS. However, FPG, HbA1c and HOMA-IR levels were significantly inversely correlated with TBS after adjusting for age, BMI and aBMD. Multivariate linear regression analyses revealed that glycemic indices (FPG and HbA1c) were significantly associated with increased aBMD and decreased TBS, and that HOMA-IR was associated only with TBS. These associations did not change after further adjusting for bone turnover makers and pentosidine levels.
Conclusions: Hyperglycemia and elevated insulin-resistance were associated with low TBS independently of bone turnover and pentosidine levels. (C) 2017 Elsevier Inc. All rights reserved.
- Muscle strength is associated with bone health independently of muscle mass in postmenopausal women: the Japanese population-based osteoporosis study., Tachiki T, Kouda K, Dongmei N, Tamaki J, Iki M, Kitagawa J, Takahira N, Sato Y, Kajita E, Fujita Y, Yura A, Kagamimori S, Journal of bone and mineral metabolism, Journal of bone and mineral metabolism, 2017年12月, 査読有り
- Recent advances in understanding basophil-mediated Th2 immune responses, Yoshinori Yamanishi, Kensuke Miyake, Misako Iki, Hidemitsu Tsutsui, Hajime Karasuyama, IMMUNOLOGICAL REVIEWS, IMMUNOLOGICAL REVIEWS, 278, 1, 237, 245, 2017年07月, 査読有り
概要：Basophils, the least common granulocytes, represent only similar to 0.5% of peripheral blood leukocytes. Because of the small number and some similarity with mast cells, the functional significance of basophils remained questionable for a long time. Recent studies using newly-developed analytical tools have revealed crucial and non-redundant roles for basophils in various immune responses, particularly Th2 immunity including allergy and protective immunity against parasitic infections. In this review, we discuss the mechanisms how basophils mediate Th2 immune responses and the nature of basophil-derived factors involved in them. Activated basophils release serine proteases, mouse mast cell protease 8 (mMCP-8), and mMCP-11, that are preferentially expressed by basophils rather than mast cells in spite of their names. These proteases elicit microvascular hyperpermeability and leukocyte infiltration in affected tissues, leading to inflammation. Basophil-derived IL-4 also contributes to eosinophil infiltration while it acts on tissue-infiltrating inflammatory monocytes to promote their differentiation into M2 macrophages that in turn dampen inflammation. Although basophils produce little or no MHC class II (MHC-II) proteins, they can acquire peptide-MHC-II complexes from dendritic cells via trogocytosis and present them together with IL-4 to naive CD4 T cells, leading to Th2 cell differentiation. Thus, basophils contribute to Th2 immunity at various levels.
- Total 25-hydroxyvitamin D levels predict fracture risk: results from the 15-year follow-up of the Japanese Population-based Osteoporosis (JPOS) Cohort Study, J. Tamaki, M. Iki, Y. Sato, E. Kajita, H. Nishino, T. Akiba, T. Matsumoto, S. Kagamimori, OSTEOPOROSIS INTERNATIONAL, OSTEOPOROSIS INTERNATIONAL, 28, 6, 1903, 1913, 2017年06月, 査読有り
概要：We found that community-dwelling women with 25-hydroxyvitamin D levels < 20 ng/mL compared to levels >= 20 ng/mL indicated increased risks for clinical, non-vertebral, and fragility fractures during 5 years. Furthermore, the increased risks of non-vertebral fractures remained significant in 10 and 15 years after adjusting for age and bone mineral density.
We examined whether total 25-hydroxyvitamin D (25[OH]D) levels are associated with fracture risk over 15 years in a Japanese female cohort.
Of 1437 community-dwelling women aged >= 50 years in the baseline survey, 1236 provided information regarding fractures during a 15-year follow-up period. The analysis included 1211 women without early menopause or diseases affecting bone metabolism.
Over 15 years, 269 clinical (224 non-vertebral, 149 fragility) fracture events were confirmed. Incidence rates categorized by 25(OH)D levels (< 10, 10-20, 20-30, and >= 30 ng/mL) indicated a significant divergence for any clinical fractures in 5 years (log rank test p = 0.016) and for non-vertebral fractures in 5, 10, and 15 years (p < 0.001, p = 0.001, p = 0.017, respectively). Hazard ratios (HRs) for 25(OH)D levels < 10 and 10-20 ng/mL compared to levels >= 30 ng/mL during 5 years indicated significances for clinical fractures (HR 4.93 with p = 0.009, HR 3.00 with p = 0.034) and for non-vertebral fractures (HR 6.55 with p = 0.005, HR 3.49 with p = 0.036). Those with levels < 20 ng/mL compared to those with levels >= 20 ng/mL indicated significant increased risks for clinical fractures (HR 1.72 with p = 0.010), non-vertebral fractures (HR 2.45 with p < 0.001), and fragility fractures (HR 2.00 with p = 0.032) in 5 years. The HR of non-vertebral fractures for levels < 20 ng/mL remained significant during 15 years (HR 1.42 with p = 0.012) after adjustment for age and femoral neck bone mineral density.
Low 25(OH)D levels, especially < 20 ng/mL, were associated with elevated fracture risks in Japanese women.
- Predicting bone mineral acquisition during puberty: data from a 3-year follow-up study in Hamamatsu, Japan, Katsuyasu Kouda, Kumiko Ohara, Harunobu Nakamura, Yuki Fujita, Masayuki Iki, JOURNAL OF BONE AND MINERAL METABOLISM, JOURNAL OF BONE AND MINERAL METABOLISM, 35, 2, 185, 191, 2017年03月, 査読有り
概要：Although most adult bone mass is acquired before adolescence, only a few studies have assessed bone turnover markers in children. Thus, the utility of bone markers to evaluate and predict bone mineral accrual in children is unclear. The present study assessed the association between serum bone markers at 11 years of age and subsequent changes in bone gain. Information on bone minerals and bone markers at baseline and at the 3-year follow- up were obtained from 121 children who registered as fifth-grade students in 2010, in Hamamatsu, Japan. Wholebody bone mineral content (WBBMC) and whole-body bone mineral density (WBBMD) were measured using dual-energy X-ray absorptiometry. Boys showed significant (P < 0.05) positive relationships between intact osteocalcin at baseline and WBBMC at follow-up (beta = 0.24), between tartrate-resistant acid phosphatase isoenzyme 5b (TRAP5b) and WBBMC (beta = 0.34), and between TRAP5b and WBBMD (beta = 0.34), after adjusting for potential confounding factors. In girls, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of type 1 collagen crosslinked C-terminal telopeptide. In boys, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of TRAP5b. Children with a high concentration of bone turnover markers tended to exhibit substantial accrual of bone minerals. These results suggest that serum levels of circulating biomarkers at age 11 predict subsequent bone mineral accrual.
- Increased Ratio of Trunk-to-Appendicular Fat and Decreased Adiponectin: A Population-Based Study of School Children in Hamamatsu, Japan, Katsuyasu Kouda, Harunobu Nakamura, Kumiko Ohara, Yuki Fujita, Masayuki Iki, JOURNAL OF CLINICAL DENSITOMETRY, JOURNAL OF CLINICAL DENSITOMETRY, 20, 1, 66, 72, 2017年01月, 査読有り
概要：Very few epidemiological studies have examined the relative impact of visceral fat and subcutaneous fat on serum adiponectin levels. Trunk-to-extremity fat ratio is reportedly a better surrogate for visceral fat than for subcutaneous fat. In the present study, we investigated the association between adiponectin and trunk-to-appendicular fat ratio (TAR) in a school population. The source population was all fifth graders (799 pupils) enrolled in the 2 elementary schools in Hamamatsu, Japan. Of the source population, we analyzed cross-sectional data from 609 children (mean age: 11.2 yr). TAR was evaluated by dual-energy X-ray absorptiometry and calculated as trunk fat mass divided by appendicular (arms and legs) fat mass. After stratification by tertiles of total body fat, multiple regression analysis was used to examine the relationships between adiponectin and TAR adjusted for potential confounding factors. In the highest tertile of total body fat, increasing TARs were significantly (p < 0.05) associated with decreasing serum adiponectin levels after stratification by total body fat (beta = -0.32 in boys; beta = -0.31 in girls). In the second tertile of total body fat, TAR in girls also showed significant inverse relationships with serum adiponectin levels (beta = -0.27). Data from this population-based study demonstrated that an increased proportion of trunk fat is associated with decreased adiponectin in relatively overweight children, and also demonstrated that girls with a normal volume of body fat that follows a more centralized distribution show decreased adiponectin.
- Relative Importance of Central and Peripheral Adiposities on Cardiometabolic Variables in Females: A Japanese Population-Based Study, Katsuyasu Kouda, Namiraa Dongmei, Junko Tamaki, Masayuki Iki, Takahiro Tachiki, Etsuko Kajita, Yoshimi Nakatani, Kazuhiro Uenishi, Sadanobu Kagamimori, Yoshiko Kagawa, Hideo Yoneshima, JOURNAL OF CLINICAL DENSITOMETRY, JOURNAL OF CLINICAL DENSITOMETRY, 20, 1, 58, 65, 2017年01月, 査読有り
概要：In epidemiological studies, there is little evidence regarding the relative impact of central adiposity and peripheral adiposity on cardiometabolic risk factors, especially in Asian populations. This study investigated associations between central-to-peripheral fat ratios and cardiometabolic variables using data from a population based study of Japanese women. The source population was composed of 1800 women aged 50 yr or older at the 15th- to 16th-yr follow-up survey of the Japanese Population-Based Osteoporosis Cohort Study. This study analyzed cross-sectional data from 998 women for whom complete information about body fat variables according to dual-energy X-ray absorptiometry, cardiometabolic variables, and potential confounding factors was available. Both before and after adjusting for potential confounding factors, trunk-to-appendicular fat ratios showed significant (p < 0.05) correlations with brachial ankle pulse wave velocity, serum lipids, and hemoglobin A1c levels. Relationships between fat ratios and cardiometabolic variables were independent of relationships between fat volumes (in whole body or in trunk) and cardiometabolic variables. Furthermore, relationships between trunk-to-appendicular fat ratios and cardiometabolic variables were observed among women in the lowest tertile of total body fat (brachial ankle pulse wave velocity, beta = 0.08; high-density lipoprotein cholesterol, beta = -0.32; low-density lipoprotein cholesterol, beta = 0.15; and hemoglobin A1C, beta = 0.16; p < 0.05, respectively). Central adiposity is more related to cardiometabolic variables than peripheral adiposity. Information on central-to-peripheral fat ratios is particularly valuable for the evaluation of relatively thin Japanese women.
- Trunk-to-Peripheral Fat Ratio Predicts Subsequent Blood Pressure Levels in Pubertal Children With Relatively Low Body Fat - Three-Year Follow-up Study., Kouda K, Ohara K, Fujita Y, Nakamura H, Iki M, Circulation journal : official journal of the Japanese Circulation Society, Circulation journal : official journal of the Japanese Circulation Society, 80, 8, 1838, 1845, 2016年07月, 査読有り
- [Risk factors for osteoporosis in men from the Fujiwara-kyo Osteoporosis Risk in Men study]., Fujita Y, Iki M, Clinical calcium, Clinical calcium, 26, 7, 1031, 1037, 2016年07月, 査読有り
- Inverse association between height increase and LDL cholesterol during puberty: A 3-year follow-up study of the Fukuroi City., Fujita Y, Kouda K, Nakamura H, Iki M, American journal of human biology : the official journal of the Human Biology Council, American journal of human biology : the official journal of the Human Biology Council, 28, 3, 330, 334, 2016年05月, 査読有り
- A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX., McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, Barkmann R, Boutroy S, Brown J, Chapurlat R, Elders PJ, Fujita Y, Glüer CC, Goltzman D, Iki M, Karlsson M, Kindmark A, Kotowicz M, Kurumatani N, Kwok T, Lamy O, Leung J, Lippuner K, Ljunggren Ö, Lorentzon M, Mellström D, Merlijn T, Oei L, Ohlsson C, Pasco JA, Rivadeneira F, Rosengren B, Sornay-Rendu E, Szulc P, Tamaki J, Kanis JA, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 31, 5, 940, 948, 2016年05月, 査読有り
- Significance of baseline bone markers on disease progression and survival in hormone-sensitive prostate cancer with bone metastasis., Masahiro Nozawa, Isao Hara, Hideyasu Matsuyama, Masayuki Iki, Kazuhiro Nagao, Tsukasa Nishioka, Takahiro Komura, Atsunobu Esa, Shigeya Uejima, Masaaki Imanishi, Yasunari Uekado, Takatoshi Ogawa, Hiroshi Kajikawa, Hirotsugu Uemura, World journal of urology, World journal of urology, 33, 9, 1263, 8, 2015年09月, 査読有り
概要：PURPOSE: This study evaluated the baseline patient characteristics associated with the time to biochemical progression and overall survival in patients who participated in a phase II trial on zoledronic acid combined with the initial androgen-deprivation therapy for treatment-naïve bone-metastatic prostate cancer. METHODS: Patients received zoledronic acid 4 mg intravenously every 4 weeks for up to 24 months, concomitantly started with bicalutamide 80 mg orally every day and goserelin acetate 10.8 mg subcutaneously every 12 weeks. RESULTS: A total of 53 Japanese patients were enrolled between July 2008 and April 2010, and 52 patients were evaluable. Median follow-up period was 41.6 months. Updated median time to biochemical progression was 25.9 months (95 % confidence interval 14.5-49.9). Higher serum bone-specific alkaline phosphatase was an independent risk factor for time to biochemical progression based on multivariate analysis (hazard ratio 6.51; 95 % confidence interval 2.71-15.62; P < 0.001). Median time to biochemical progression for patients with serum bone-specific alkaline phosphatase level higher than 26 μg/L was 12.7 months. Multivariate analysis indicated that higher serum C-terminal telopeptide of type I collagen independently increased the risk of death (hazard ratio 9.62; 95 % confidence interval 2.11-43.89; P = 0.003). Median overall survival for patients with serum C-terminal telopeptide of type I collagen level higher than 8.0 ng/ml was 31.1 months. CONCLUSIONS: Baseline bone markers can be useful as predictors for disease progression and survival time in patients with bone metastasis from treatment-naïve prostate cancer treated with upfront zoledronic acid concomitantly started with androgen-deprivation therapy.
- Cohort Profile: The Japanese Population-based Osteoporosis (JPOS) Cohort Study., Iki M, Tamaki J, Sato Y, Morita A, Ikeda Y, Kajita E, Nishino H, Akiba T, Matsumoto T, Kagamimori S, Kagawa Y, Yoneshima H, Matsukura T, Yamagami T, Kitagawa J, JPOS Study Group, International journal of epidemiology, International journal of epidemiology, 44, 2, 405, 414, 2015年04月, 査読有り
- HDL subclasses are heterogeneous in their associations with body fat, as measured by dual-energy X-ray absorptiometry: the Kitakata Kids Health Study., Kouda K, Nakamura H, Fujita Y, Hamada M, Kajita E, Nakatani Y, Sato Y, Uenishi K, Iki M, Clinica chimica acta; international journal of clinical chemistry, Clinica chimica acta; international journal of clinical chemistry, 444, 101, 105, 2015年04月, 査読有り
- Fat mass is positively associated with bone mass in relatively thin adolescents: Data from the Kitakata Kids Health Study, Katsuyasu Kouda, Yuki Fujita, Yuho Sato, Kumiko Ohara, Harunobu Nakamura, Kazuhiro Uenishi, Masayuki Iki, BONE, BONE, 64, 298, 302, 2014年07月, 査読有り
概要：Epidemiologic studies have found that higher body weight is associated with better bone health. Body weight consists of both fat mass (FM) and lean soft tissue mass (LSTM). Previous studies have examined the effects of FM levels during childhood on bone health, with conflicting results. In the present study, we investigated the independent contributions of FM to bone mass in Japanese adolescents. Subjects were 235 adolescents aged 15-18 years old in August 2010 and in August 2013 from the Kitakata Kids Health Study in Japan. We obtained cross-sectional data on body composition as well as bone mineral density (BMD). Body composition and BMD were measured using a dual-energy X-ray absorptiometry scanner. We found moderate and positive relationships between FM index and LSTM index (males, r = 0.69; females, r = 0.44). To verify a potentially additive effect of FM on the variance of bone variables beyond LSTM, we assessed the association between FM index and bone variables after stratification by tertiles of the LSTM index. In the lowest tertile of the LSTM index, FM index was significantly (P < 0.05) associated with both femoral neck BMD (males, beta = 0.48; females, beta = 033) and whole body BMC (males, beta = 0.41; females, beta = 0.25). On the other hand, we found no significant associations between FM index and bone variables in other tertiles of the LSTM index. These findings indicate that FM can influence how high bone mass is obtained among relatively thin adolescents, but not among those who are of normal weight or overweight. (C) 2014 Elsevier Inc. All rights reserved.
- [Epidemiology of bone and joint disease - the present and future - . Epidemiology of osteoporosis and osteoporotic fracture in Japan]., Iki M, Clinical calcium, Clinical calcium, 24, 5, 657, 664, 2014年05月, 査読有り
- Trabecular Bone Score (TBS) Predicts Vertebral Fractures in Japanese Women Over 10 Years Independently of Bone Density and Prevalent Vertebral Deformity: The Japanese Population-Based Osteoporosis (JPOS) Cohort Study, Masayuki Iki, Junko Tamaki, Eiko Kadowaki, Yuho Sato, Namiraa Dongmei, Renaud Winzenrieth, Sadanobu Kagamimori, Yoshiko Kagawa, Hideo Yoneshima, JOURNAL OF BONE AND MINERAL RESEARCH, JOURNAL OF BONE AND MINERAL RESEARCH, 29, 2, 399, 407, 2014年02月, 査読有り
概要：Bone strength is predominantly determined by bone density, but bone microarchitecture also plays an important role. We examined whether trabecular bone score (TBS) predicts the risk of vertebral fractures in a Japanese female cohort. Of 1950 randomly selected women aged 15 to 79 years, we analyzed data from 665 women aged 50 years and older, who completed the baseline study and at least one follow-up survey over 10 years, and who had no conditions affecting bone metabolism. Each survey included spinal imaging by dual-energy X-ray absorptiometry (DXA) for vertebral fracture assessment and spine areal bone mineral density (aBMD) measurement. TBS was obtained from spine DXA scans archived in the baseline study. Incident vertebral fracture was determined when vertebral height was reduced by 20% or more and satisfied McCloskey-Kanis criteria or Genant's grade 2 fracture at follow-up. Among eligible women (mean age 64.1 +/- 8.1 years), 92 suffered incident vertebral fractures (16.7/10(3) person-years). These women were older with lower aBMD and TBS values relative to those without fractures. The unadjusted odds ratio of vertebral fractures for one standard deviation decrease in TBS was 1.98 (95% confidence interval [CI] 1.56, 2.51) and remained significant (1.64, 95% CI 1.25, 2.15) after adjusting for aBMD. The area under the receiver operating characteristic curve of TBS and aBMD combined was 0.700 for vertebral fracture prediction and was not significantly greater than that of aBMD alone (0.673). However, reclassification improvement measures indicated that TBS and aBMD combined significantly improved risk prediction accuracy compared with aBMD alone. Further inclusion of age and prevalent vertebral deformity in the model improved vertebral fracture prediction, and TBS remained significant in the model. Thus, lower TBS was associated with higher risk of vertebral fracture over 10 years independently of aBMD and clinical risk factors including prevalent vertebral deformity. TBS could effectively improve fracture risk assessment in clinical settings. (c) 2014 American Society for Bone and Mineral Research.
- Growth-related disappearance of the childhood relationship between height and blood pressure levels, Yuki Fujita, Katsuyasu Kouda, Harunobu Nakamura, Nobuhiro Nishio, Hiroichi Takeuchi, Masayuki Iki, ANNALS OF HUMAN BIOLOGY, ANNALS OF HUMAN BIOLOGY, 41, 1, 91, 93, 2014年01月, 査読有り
概要：Context: Although there is a positive relationship between height and blood pressure (BP) levels in children, there are no reports regarding the association between height and BP levels in adolescents and adults.
Objective: This study examined whether there is an association between height and BP levels in Japanese adolescents.
Methods: The source population was all fifth (10 and 11-year-olds) and ninth graders (14 and 15-year-olds) who attended 11 elementary schools and five junior high schools in the Iwata area from 2002-2008. School-based screenings were conducted annually by the local government from April to June. Data obtained from health examinations were analysed, including anthropometric measurements and BP levels, for 11 780 children (98.7% of the source population).
Results: Height showed significant positive relationships with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in childhood and in adolescent males. In contrast, the relationship between height and SBP was significantly weaker in adolescent females than in childhood and there was no significant relationship between height and DBP in adolescent females.
Conclusion: The relationship between height and SBP was attenuated by development in females and the relationship between height and DBP disappeared.
- Association of Rapid Weight Gain During Early Childhood With Cardiovascular Risk Factors in Japanese Adolescents, 藤田 裕規, 甲田 勝康, 伊木 雅之, Nakamura H, J Epidemiol, J Epidemiol, 23, 2, 103, 108, 2013年12月, 査読有り
- Association between depressive symptoms and metabolic syndrome in Japanese community-dwelling older people: a cross-sectional analysis from the baseline results of the Fujiwara-kyo prospective cohort study., Morikawa M, Okamoto N, Kiuchi K, Tomioka K, Iwamoto J, Harano A, Saeki K, Fukusumi M, Hashimoto K, Amano N, Hazaki K, Yanagi M, Iki M, Yamada F, Kishimoto T, Kurumatani N, International journal of geriatric psychiatry, International journal of geriatric psychiatry, 28, 12, 1251, 1259, 2013年12月, 査読有り
- Vitamin D status and body fat measured by dual-energy X-ray absorptiometry in a general population of Japanese children., 甲田 勝康, 藤田 裕規, 伊木 雅之, Harunobu Nakamura, Kumiko Ohara, Nutrition, Nutrition, 29, 10, 1204, 1208, 2013年10月, 査読有り
- Renal function and bone mineral density in community-dwelling elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study., 藤田 裕規, 伊木 雅之, 甲田 勝康, 由良 晶子, Junko Tamaki, Eiko Kadowaki, Yuho Sato, Jong-Seong Moon, Kimiko Tomioka, Nozomi Okamoto, Norio Kurumatani, Bone, Bone, 56, 1, 61, 66, 2013年10月
- Renal function and bone mineral density in community-dwelling elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study., Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N, Bone, Bone, 56, 1, 61, 66, 2013年09月, 査読有り
- Growth-related disappearance of the childhood relationship between height and blood pressure levels., 藤田 裕規, 甲田 勝康, 伊木 雅之, Harunobu Nakamura, Nobuhiro Nishio, Hiroichi Takeuchi, Ann Hum biol, Ann Hum biol, 1, 3, 2013年08月
- Biochemical markers for bone turnover predict risk of vertebral fractures in postmenopausal women over 10 years: the Japanese Population-based Osteoporosis (JPOS) Cohort Study, 玉置 淳子, 伊木 雅之, E. Kadowaki, Y. Sato, Y. Chiba, T. Akiba, T. Matsumoto, H. Nishino, S. Kagamimori, Y. Kagawa, H. Yoneshima, Osteoporos Int, Osteoporos Int, 24, 887, 897, 2013年
- Increased ratio of trunk to appendicular fat and increased blood pressure: study of a general population of Hamamatsu children, 甲田 勝康, 藤田 裕規, 伊木 雅之, Nakamura H, Ohara K, Circ J, Circ J, 76, 12, 2848, 2854, 2012年12月, 査読有り
- Relationship between body mass index at age 3 years and body composition at age 11 years among Japanese children: the Shizuoka population-based study, 甲田 勝康, 藤田 裕規, 伊木 雅之, Harunobu Nakamura, J Epidemiol, J Epidemiol, 22, 5, 411, 416, 2012年09月, 査読有り
- A screening model for low bone mass in elderly Japanese men using quantitative ultrasound measurements: Fujiwara-Kyo Study., Minematsu A, Hazaki K, Harano A, Iki M, Fujita Y, Okamoto N, Kurumatani N, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 15, 3, 343, 350, 2012年07月, 査読有り
- [Epidemiology of osteoporosis in Japan]., Iki M, Clinical calcium, Clinical calcium, 22, 6, 797, 803, 2012年06月, 査読有り
- Response to "Effects of Vitamin K intake on gamma-carboxylated proteins, bone fractures, and vascular calcifications", 藤田 裕規, 伊木 雅之, 甲田 勝康, 由良 晶子, J. Tamaki, E. Kadowaki, Y. Sato, J.S. Moon, K. Tomioka, N. Okamoto, N. Kurumatani, Osteoporos Int, Osteoporos Int, 23, 5, 1639, 1640, 2012年05月
- Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study, 伊木 雅之, 藤田 裕規, 甲田 勝康, 由良 晶子, J. Tamaki, E. Kadowaki, Y. Sato, J.S. Moon, K. Tomioka, N. Okamoto, N. Kurumatani, Osteoporos Int, Osteoporos Int, 23, 2, 761, 770, 2012年02月
- Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study, 藤田 裕規, 伊木 雅之, 甲田 勝康, 由良 晶子, J. Tamaki, E. Kadowaki, Y. Sato, J.-S. Moon, K. Tomioka, N. Okamoto, N. Kurumatani, Osteoporos Int, Osteoporos Int, 23, 2, 705, 714, 2012年02月
- 血清低カルボキシル化オステオカルシン濃度はインスリン抵抗性指標と関連するか 健常高齢者，ワルファリン服用者，ビスホスホネート服用者での比較検討., 伊木 雅之, 玉置 淳子, 車谷典男, Osteoporosis Japan Osteoporosis Japan, Osteoporosis Japan Osteoporosis Japan, 20, 4, 669, 675, 2012年
- Effect of distributing an evidence-based guideline for prevention of osteoporosis on health education programs in municipal health centers: a randomized controlled trial., Nakatani Y, Tamaki J, Komatsu M, Iki M, Kajita E, Journal of epidemiology, Journal of epidemiology, 22, 2, 103, 112, 2012年, 査読有り
- Japanese 2011 guidelines for prevention and treatment of osteoporosis--executive summary., Orimo H, Nakamura T, Hosoi T, Iki M, Uenishi K, Endo N, Ohta H, Shiraki M, Sugimoto T, Suzuki T, Soen S, Nishizawa Y, Hagino H, Fukunaga M, Fujiwara S, Archives of osteoporosis, Archives of osteoporosis, 7, 3, 20, 2012年, 査読有り
- Effect of recovery from obesity on cardiovascular risk factors among Japanese schoolchildren: the Iwata population-based follow-up study, 甲田 勝康, 藤田 裕規, 伊木 雅之, Nakamura H, Takeuchi H, J Epidemiol, J Epidemiol, 21, 5, 370, 375, 2011年09月, 査読有り
- Trends of allergic symptoms in school children: Large-scale long-term consecutive cross-sectional studies in Osaka Prefecture, Japan, 由良 晶子, 甲田 勝康, 伊木 雅之, Shimizu T, Pediatr Allergy Immunol, Pediatr Allergy Immunol, 22, 6, 631, 637, 2011年09月, 査読有り
- [Difference in osteoporosis in men and women]., Iki M, Clinical calcium, Clinical calcium, 21, 9, 1377, 1383, 2011年09月, 査読有り
- Alcohol intake and bone status in elderly Japanese men: baseline data from the Fujiwara-kyo osteoporosis risk in men (FORMEN) study, 甲田 勝康, 伊木 雅之, 藤田 裕規, 由良 晶子, Junko Tamaki, Eiko Kadowaki, Yuho Sato, Jong-Seong Moon, Masayuki Morikawa, Kimiko Tomioka, Nozomi Okamoto, Norio Kurumatani, Bone, Bone, 49, 2, 275, 280, 2011年08月, 査読有り
- Intermittent fasting ameliorates delayed-type hypersensitivity in NC/Nga mice, Hirao Kohno, 甲田 勝康, 伊木 雅之, Hiroyasu Ishihara Yutaka, Sasaki, Yoshiaki Sonoda, Nobuhiro Nishio, Harunobu Nakamura, Food and Nutrition Sciences, Food and Nutrition Sciences, 2, 4, 287, 293, 2011年06月
- Cut-off values of body mass index, waist circumference, and waist-to-height ratio to identify excess abdominal fat: population-based screening of Japanese school children, 藤田 裕規, 甲田 勝康, 伊木 雅之, Nakamura H, J Epidemiol, J Epidemiol, 21, 3, 191, 196, 2011年05月, 査読有り
- 地域医療実習による学生の意識変化と地域指向性との関連 : 和歌山県東牟婁郡串本町における地域医療教育, 岩崎 拓也, 竹山 宜典, 伊木 雅之, 伊藤 浩行, 大柳 治正, 塩崎 均, 松尾 理, 医学教育 = Medical education, 医学教育 = Medical education, 42, 2, 101, 112, 2011年04月25日
- Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study, J. Tamaki, 伊木 雅之, 藤田 裕規, 甲田 勝康, 由良 晶子, E. Kadowaki, Y. Sato, J. S. Moon, K. Tomioka, N. Okamoto, N. Kurumatani, Osteoporos Int, Osteoporos Int, 22, 1, 133, 141, 2011年04月
- Height-specific serum cholesterol levels in pubertal children: data from population-based Japanese school screening, 藤田 裕規, 甲田 勝康, 伊木 雅之, Harunobu Nakamura, Nobuhiro Nishio, Hiroichi Takeuchi, J Epidemiol, J Epidemiol, 21, 2, 102, 107, 2011年03月, 査読有り
- Tracking of appendicular bone mineral density for 6 years including the pubertal growth spurt: Japanese Population-based Osteoporosis kids cohort study., Fujita Y, Iki M, Ikeda Y, Morita A, Matsukura T, Nishino H, Yamagami T, Kagamimori S, Kagawa Y, Yoneshima H, Journal of bone and mineral metabolism, Journal of bone and mineral metabolism, 29, 2, 208, 216, 2011年03月, 査読有り
- Fracture risk prediction using FRAXR: a 10-year follow-up survey of the Japanese Population-Based Osteoporosis (JPOS) Cohort Study, 玉置 淳子, 伊木 雅之, 門脇 英子, 佐藤 裕保, 梶田 悦子, 鏡森 定信, 香川 芳子, 米島 秀夫, Osteoporos Int, Osteoporos Int, 22, 3037, 3045, 2011年
- Impact of smoking on bone mineral density and bone Risk in Men (FORMEN) study, 玉置 淳子, 伊木 雅之, 藤田 裕規, 甲田 勝康, 由良 晶子, 門脇 英子, 佐藤 裕保, 文 鐘聲, 冨岡 公子, 本, 希, 車谷 典男, Osteoporos Int, Osteoporos Int, 22, 133, 141, 2011年
- 降圧薬は骨量低下を抑制するか 骨粗鬆症のリスク要因の解明をめざす藤原京スタディ男性骨折コホート研究, 玉置 淳子, 伊木 雅之, 大和証券ヘルス財団研究業績集, 大和証券ヘルス財団研究業績集, 34, 100, 105, 2011年
- Relationship between height and blood pressure in Japanese schoolchildren, 藤田 裕規, 甲田 勝康, 伊木 雅之, Harunobu Nakamura, Nobuhiro Nishio, Hiroichi Takeuchi, Pediatr Int, Pediatr Int, 52, 5, 689, 693, 2010年10月, 査読有り
- Beneficial effects of mild stress (hormetic effects): dietary restriction and health, 甲田 勝康, 伊木 雅之, J Physiol Anthropol, J Physiol Anthropol, 29, 4, 127, 132, 2010年10月, 査読有り
- Smoking among premenopausal women is associated with increased risk of low bone status: the JPOS Study, 玉置 淳子, 伊木 雅之, 佐藤 裕保, 梶田 悦子, 鏡森 定信, 香川 芳子, 米島 秀夫, J Bone Miner Metab, J Bone Miner Metab, 28, 3, 320, 327, 2010年05月, 査読有り
- Trends in body mass index, blood pressure, and serum lipids in Japanese children: Iwata population-based annual screening (1993-2008), 甲田 勝康, 藤田 裕規, 伊木 雅之, Harunobu Nakamura, Nobuhiro Nishio, Hiroichi Takeuchi, J Epidemiol, J Epidemiol, 20, 3, 212, 218, 2010年05月, 査読有り
- Prevalent vertebral deformity independently increases incident vertebral fracture risk in middle-aged and elderly Japanese women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study, 門脇 英子, 玉置 淳子, 伊木 雅之, Y. Sato, Y. Chiba, E. Kajita, S. Kagamimori, Y. Kagawa, H. Yoneshima, Osteoporos Int, Osteoporos Int, 21, 1513, 1522, 2010年
- 大規模無作為抽出標本の10年追跡データによる日本人女性におけるFRAXの有用性の検討 JPOSコホート研究, 玉置 淳子, 伊木 雅之, Osteoporosis Japan Osteoporosis Japan, Osteoporosis Japan Osteoporosis Japan, 8, 415, 422, 2010年
- Arm span increases predictive value of models for prevalent vertebral deformities: The Japanese Population-based Osteoporosis (JPOS) Study, 玉置 淳子, 伊木 雅之, 門脇 英子, Yuho Sato, Sadanobu Kagamimoric, Yoshiko Kagawad, Hideo Yoneshimae, Maturitas, Maturitas, 20, 4, 241, 245, 2009年12月, 査読有り
- Design and baseline characteristics of a prospective cohort study for determinants of osteoporotic fracture in community-dwelling elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study, 伊木 雅之, 藤田 裕規, 玉置 淳子, 甲田 勝康, 由良 晶子, Eiko Kadowaki, Yuho Sato, Jong-Seong Moon, Nozomi Okamoto, Norio Kurumatani, BMC Musculoskeletal Disorders, BMC Musculoskeletal Disorders, 10, 165, 2009年12月, 査読有り
- 適度の栄養ストレスによる寿命延長と疾病抑制効果, 甲田 勝康, 伊木 雅之, 日本医事新報, 日本医事新報, 4440, 37, 40, 2009年05月
- 絶食と食餌制限：基礎研究と臨床研究, 甲田 勝康, 伊木 雅之, 中村晴信, 脂質栄養学, 脂質栄養学, 18, 1, 71, 79, 2009年05月
- Technetium-99m-GSA clearance in mice under long-term dietary restriction, 甲田 勝康, 伊木 雅之, H. Kohno, Y. Sonoda, H. Nakamura, S.K. Ha-Kawa, Ann Nucl Med, Ann Nucl Med, 23, 2, 123, 129, 2009年02月, 査読有り
- Low bone mass is associated with carotid atherosclerosis in postmenopausal women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study, 玉置 淳子, 伊木 雅之, 平野 豊, 佐藤 裕保, 梶田 悦子, 鏡森 定信, 香川 芳子, 米島 秀夫, Osteoporos Int, Osteoporos Int, 20, 53, 60, 2009年
- Peroxisome proliferator-activated receptor gamma polymorphism is related to peak bone mass: the JPOS study, 玉置 淳子, 伊木 雅之, 森田 明美, 池田 行宏, 佐藤 裕保, 梶田 悦子, 鏡森 定信, 香川 芳子, 米島 秀夫, Osteoporos Int, Osteoporos Int, 1, 321, 329, 2009年
- 男性の骨粗鬆症とそれによる要介護化を防止する知･体･食･住への総合的アプローチ, 玉置 淳子, 藤田 裕規, 伊木 雅之, 森川 将行, 財団法人総合健康推進財団平成19年度研究報告書, 財団法人総合健康推進財団平成19年度研究報告書, 24, 40, 55, 2009年
- Use of anthropometric indicators in screening for undiagnosed vertebral fractures: a cross-sectional analysis of the Fukui Osteoporosis Cohort (FOC) study., Abe K, Tamaki J, Kadowaki E, Sato Y, Morita A, Komatsu M, Takeuchi S, Kajita E, Iki M, Fukui Osteoporosis Cohort, BMC musculoskeletal disorders, BMC musculoskeletal disorders, 9, 157, 2008年11月, 査読有り
- 全国市区町村におけるエビデンスに基づく骨粗鬆症予防対策の実施状況と関連要因, 小松 美砂, 梶田 悦子, 玉置 淳子, 中谷 芳美, 由良 晶子, 伊木 雅之, 民族衞生, 民族衞生, 74, 4, 164, 177, 2008年07月31日
- Use of Anthropometric Indicators in Screening for Undiagnosed Vertebral Deformities: A Cross-sectional Analysis of the Fukui Osteoporosis Cohort (FOC) Study, Kiyoko Abe, 玉置 淳子, 伊木 雅之, Eiko Kadowaki, Yuho Sato, Akemi Morita, Misa Komatsu, Sayaka Takeuchi, Etsuko Kajita, BMC Musculodkelet Disord, BMC Musculodkelet Disord, 157, 2008年
- Which element of physical activity is more important for determining bone growth in Japanese children and adolescents: the degree of impact, the period, the frequency, or the daily duration of physical activity?, 玉置 淳子, 伊木 雅之, 池田 行宏, 森田 明美, 佐藤 裕保, 中 比呂志, J Bone Miner Metab, J Bone Miner Metab, 26, 4, 366, 372, 2008年, 査読有り
- 全国市町村におけるエビデンスに基づく骨粗鬆症予防対策の実施状況と関連要因, 小松美砂, 玉置 淳子, 由良 晶子, 伊木 雅之, 梶田悦子, 中谷芳美, 民族衛生, 民族衛生, 7, 164, 177, 2008年
- 小学生から高校生にいたる中軸骨骨発達の６年間追跡に基づく思春期骨折のリスク要因の解明と骨折予防プログラムの立案, 伊木 雅之, 玉置 淳子, 藤田 裕規, 甲田 勝康, 由良 晶子, 門脇 英子, 梶田 悦子, 社団法人日本酪農乳業協会、平成１９年度牛乳栄養素等調査研究及び牛乳・乳製品機能性実証調査報告書, 社団法人日本酪農乳業協会、平成１９年度牛乳栄養素等調査研究及び牛乳・乳製品機能性実証調査報告書, 51, 88, 2008年
- 小学生から高校生にいたる中軸骨骨発達の６年間追跡に基づく思春期骨折のリスク要因の解明, 伊木 雅之, 玉置 淳子, 藤田 裕規, 門脇 英子, Osteoporosis Jpn Osteoporosis Jpn, Osteoporosis Jpn Osteoporosis Jpn, 16, 680, 684, 2008年
- 効率的なエビデンスコミュニケーションの実施方法に関する研究, 伊木 雅之, 玉置 淳子, エビデンスに基づく骨折予防ガイドラインの有効性評価と効率的なエビデンスコミュニケーションの実施方法に関する研究 平成１９年度統括・分担研究報告書, エビデンスに基づく骨折予防ガイドラインの有効性評価と効率的なエビデンスコミュニケーションの実施方法に関する研究 平成１９年度統括・分担研究報告書, 61, 79, 2008年
- [Absolute risk for fracture and WHO guideline. WHO model for assessing absolute risk of fracture]., Iki M, World Health Organization, Clinical calcium, Clinical calcium, 17, 7, 1015, 1021, 2007年07月, 査読有り
- 動脈硬化性疾患の管理における骨粗鬆症評価の有用性に関する研究－大規模無作為抽出標本による１０年間の追跡, 玉置 淳子, 伊木 雅之, 財団法人健康管理事業団研究助成論文集, 財団法人健康管理事業団研究助成論文集, 23, 23, 33, 2007年
- 全国市町村の骨粗鬆症対策実施状況, 伊木 雅之, 玉置 淳子, 小松 美砂, エビデンスに基づく骨折予防ガイドラインの有効性評価と効率的なエビデンスコミュニケーションの実施方法に関する研究 平成１８年度統括・分担研究報告書, エビデンスに基づく骨折予防ガイドラインの有効性評価と効率的なエビデンスコミュニケーションの実施方法に関する研究 平成１８年度統括・分担研究報告書, 17, 38, 2007年
- 骨粗鬆症は動脈硬化性心血管疾患発症リスクを高めるか－大規模無作為抽出標本の１０年追跡調査による検討, 玉置 淳子, 伊木 雅之, Osteoporosis Jpn Osteoporosis Jpn, Osteoporosis Jpn Osteoporosis Jpn, 15, 19, 26, 2007年
- Biochemical markers of bone turnover may predict progression to osteoporosis in osteopenic women: the JPOS Cohort Study., Iki M, Morita A, Ikeda Y, Sato Y, Akiba T, Matsumoto T, Nishino H, Kagamimori S, Kagawa Y, Yoneshima H, JPOS Study Group, Journal of bone and mineral metabolism, Journal of bone and mineral metabolism, 25, 2, 122, 129, 2007年, 査読有り
- [Primary, secondary and tertiary prevention of osteoporosis]., Iki M, Clinical calcium, Clinical calcium, 16, 9, 1438, 1443, 2006年09月, 査読有り
- Efficacy of optimization of vitamin D in preventing osteoporosis and osteoporotic fractures: A systematic review., Nakamura K, Iki M, Environmental health and preventive medicine, Environmental health and preventive medicine, 11, 4, 155, 170, 2006年07月, 査読有り
- Intake of Fermented Soybeans, Natto, Is Associated with Reduced Bone Loss in Postmenopausal Women: Japanese Population-based Osteoporosis (JPOS) Study, 池田 行宏, 伊木 雅之, 森田明美, 梶田悦子, 鏡森定信, 香川芳子, 米島秀夫, Journal of Nutrition, Journal of Nutrition, 136, 5, 1323, 1328, 2006年05月, 査読有り
- Trunk Muscle Strength is a Strong Predictor of Bone Loss in Postmenopausal Women, 伊木 雅之, 斉藤 幸江, 梶田 悦子, 西野 治身, 日下 幸則, CLINICAL ORTHOPAEDICS AND RELATED RESERCH, CLINICAL ORTHOPAEDICS AND RELATED RESERCH, 443, 66, 72, 2006年02月, 査読有り
- Development of a Food-Frequency Questionnaire to Measure the Dietary Calcium Intake of Adult Japanese Women, 佐藤 裕保, 玉置 淳子, 伊木 雅之, きたやま ふじこ, 日下 幸則, こでら ゆみ, こうたに あきこ, Tohoku J.Exp.Med., Tohoku J.Exp.Med., 207, 3, 217, 222, 2005年11月, 査読有り
- 新築・改築小学校における室内空気汚染と児童の健康影響実態調査, 由良 晶子, 伊木 雅之, 清水 忠彦, 日本公衆衛生雑誌, 日本公衆衛生雑誌, 52, 8, 715, 726, 2005年08月, 査読有り
- エビデンスに基づく骨折･骨粗鬆症予防ガイドライン～その地域保健における意義。骨折骨粗鬆症の1次予防についてのエビデンスに基づく勧告, 玉置 淳子, 伊木 雅之, Clinical Calcium Clinical Calcium, Clinical Calcium Clinical Calcium, 15, 8, 18, 24, 2005年08月
- [Evidence-based practice guideline for disease prevention and control and its impact on community health]., Iki M, Clinical calcium, Clinical calcium, 15, 8, 1305, 1311, 2005年08月, 査読有り
- [Evidence-based, best-practice guidelines for primary prevention of osteoporosis and osteoporotic fractures]., Tamaki J, Iki M, Clinical calcium, Clinical calcium, 15, 8, 1312, 1318, 2005年08月, 査読有り
- [Osteoporosis and smoking]., Iki M, Clinical calcium, Clinical calcium, 15, 7, 156, 158, 2005年07月, 査読有り
- Effects of the Cdx-2 Polymorphism of the Vitamin D Receptor Gene and Lifestyle Factors on Bone Mineral Density in a Representative Sample of Japanese Women:The Japanese Population-based Osteoporosis(JPOS)Study, 渡邉 明美, 伊木 雅之, 池田 行宏, 土肥祥子, 鏡森定信, 香川芳子, 米島秀夫, Calcif Tissue Int, Calcif Tissue Int, 77, 339, 347, 2005年
- Effects of pubertal development,height,weight,and grip strenght on the bone mineral density of the lumbar spine and hip in peripubertal Japanese children:Kyoto kids increase density in the skeleton study (Kyoto KIDS study), 中比呂志, 伊木 雅之, 渡邉 明美, 池田 行宏, J Bone Miner Metab, J Bone Miner Metab, 23, 463, 469, 2005年
- Relationship between distance of schools from the nearest municipal waste incineration plant and child health in Japan, 三宅 吉博, 伊木 雅之, 由良 晶子, 池田 行宏, European Journal of Epidemiology, European Journal of Epidemiology, 20, 1023, 1029, 2005年
- Effects of pubertal development, height, weight, and grip strength on the bone mineral density of the lumbar spine and hip in peripubertal Japanese children: Kyoto kids increase density in the skeleton study (Kyoto KIDS study)., Naka H, Iki M, Morita A, Ikeda Y, Journal of bone and mineral metabolism, Journal of bone and mineral metabolism, 23, 6, 463, 469, 2005年, 査読有り
- Reference database of biochemical markers of bone turnover for the Japanese female population: Japanese Population-based Osteoporosis (JPOS)Study, 伊木 雅之, 秋葉 隆, 松本 俊夫, 西野 治身, 鏡森 定信, 香川 芳子, 米増 秀夫, Osteoporosos International, Osteoporosos International, 15, 12, 981, 991, 2004年12月, 査読有り
- Precision control and seasonal variations in quantitative ultrasound measurement of the calcaneus, 池田 行宏, 伊木 雅之, Journal of Bone and Mineral Metabolism, Journal of Bone and Mineral Metabolism, 22, 6, 588, 593, 2004年12月, 査読有り
- 日本人女性を代表する標本においてビタミンD受容体多型による骨密度の予測は不確実である－JPOS studyでの検討－, 渡邉 明美, 伊木 雅之, 池田 行宏, 土肥 祥子, International Journal of Epidemiology, International Journal of Epidemiology, 33, 5, 979, 988, 2004年10月, 査読有り
- Lack of association between water hardness and coronary heart disease mortality in Japan, 三宅 吉博, 伊木 雅之, International Journal of Cardiology, International Journal of Cardiology, 96, 1, 25, 28, 2004年07月, 査読有り
- Ultrasound bone densitometry of the calcaneus with Sahara in healthy Japanese adolescents -Japanese Population-based Osteoporosis (JPOS) study-, 池田 行宏, 伊木 雅之, 渡邉 明美, 相原宏洲, 鏡森定信, 香川芳子, Journal of Bone and Mineral Metabolism, Journal of Bone and Mineral Metabolism, 22, 3, 248, 253, 2004年06月
- [Association of vitamin D receptor gene polymorphisms with osteoporosis]., Morita A, Iki M, Nihon rinsho. Japanese journal of clinical medicine, Nihon rinsho. Japanese journal of clinical medicine, 62 Suppl 2, 160, 163, 2004年02月, 査読有り
- Ecological association of water hardness with prevalence of childhood atopic dermatitis in a Japanese urban area, 三宅 吉博, 伊木 雅之, 由良 晶子, 横山 徹爾, Environmental Research, Environmental Research, 94, 1, 33, 37, 2004年01月, 査読有り
- Cross-sectional study of allergic disorders in relation to familial factors in Japanese adolescents, 三宅 吉博, 伊木 雅之, 由良 晶子, Acta Paediatr, Acta Paediatr, 93, 380, 385, 2004年
- Ultrasound bone densitometry of the calcaneus, determined with Sahara, in healthy Japanese adolescents: Japanese Population-based Osteoporosis (JPOS) Study., Ikeda Y, Iki M, Morita A, Aihara H, Kagamimori S, Kagawa Y, Matsuzaki T, Yoneshima H, Marumo F, JPOS Study Group, Journal of bone and mineral metabolism, Journal of bone and mineral metabolism, 22, 3, 248, 253, 2004年, 査読有り
- エビデンスに基づく予防対策の評価表, 伊木 雅之, 日本衛生学雑誌, 日本衛生学雑誌, 58, 3, 311, 316, 2003年09月
- エビデンスに基づく骨折・骨粗鬆症予防, 伊木 雅之, 日本衛生学雑誌, 日本衛生学雑誌, 58, 3, 311, 315, 2003年09月
- 小中学生男女の腰椎、大腿骨近位部骨密度とその決定要因に関する横断研究, 伊木 雅之, 中 比呂志, 佐藤 裕保, Osteoporosis Japan, Osteoporosis Japan, 11, 2, 86, 89, 2003年04月
- Ecologic study of water hardness and cerebrovascular mortality in Japan., Miyake Y, Iki M, Archives of environmental health, Archives of environmental health, 58, 3, 163, 166, 2003年03月, 査読有り
- 10歳代の日本人男女における骨代謝と年齢、第二次性徴との関連, 松倉 知晴, 伊木 雅之, 鏡森 定信, Annals of Human Biology, Annals of Human Biology, 30, 1, 13, 25, 2003年02月
- 日本における高い自殺死亡率と経済要因、人口学学的要因との生態学的関連, 相原 宏州, 伊木 雅之, Journal of Epidemiology, Journal of Epidemiology, 13, 1, 56, 61, 2003年01月, 査読有り
- 日本人青少年の健康と幹線道路からの距離との関連, 三宅 吉博, 伊木 雅之, 由良 晶子, Journal of Epidemiology, Journal of Epidemiology, 12, 6, 418, 423, 2002年11月, 査読有り
- Effects of socioeconomic factors on suicide from 1980 through 1999 in Osaka Prefecture, Japan., Aihara H, Iki M, Journal of epidemiology, Journal of epidemiology, 12, 6, 439, 449, 2002年11月, 査読有り
- 日本女性では、強い体幹筋力は年齢、体格、ビタミンD受容体遺伝子型とは独立して腰椎の閉経後骨量減少を減少させる, 伊木 雅之, 斎藤 幸江, 土肥 祥子, Calcified Tissue International, Calcified Tissue International, 71, 4, 300, 307, 2002年10月
- Age specific values and cutoff levels for the diagnosis of osteoporosis in quantitative ultrasound measurements at the calcaneus with SAHARA in healthy Japanese women -Japanese Population-based Osteoporosis (JPOS) study-, 池田 行宏, 伊木 雅之, 渡邉 明美, 相原宏洲, 鏡森定信, 香川芳子, 松崎俊久, 米島秀夫, 丸茂文昭, Calciffied Tissue International, Calciffied Tissue International, 71, 1, 1, 9, 2002年07月
- [Diversity in risk factors of osteoporosis]., Iki M, Clinical calcium, Clinical calcium, 12, 7, 889, 895, 2002年07月, 査読有り
- 健常日本人女性における骨代謝マーカーによる骨密度変化の予測－JPOS Cohort Study－, 伊木 雅之, 秋葉 隆, 西野 治身, Osteoporosis Japan, Osteoporosis Japan, 10, 2, 126, 129, 2002年04月
- 遺伝子多型と生活習慣による骨密度の変化, 伊木 雅之, Osteoporosis Japan, Osteoporosis Japan, 10, 1, 29, 31, 2002年02月
- 日本人女性を代表する標本集団における腰椎、大腿骨、前腕骨の骨密度 ＪＰＯＳ研究, 伊木 雅之, 鏡森 定信, 香川 芳子, Osteoporosis International, Osteoporosis International, 12, 529, 537, 2001年07月
- 日本女性における骨密度の変化の様相とその決定要因ーJPOS Cohort Studyー, 伊木 雅之, 渡邉 明美, 池田 行宏, 由良 晶子, 相原 宏州, 梶田 悦子, 鏡森 定信, 9, 2, 191, 195, 2001年04月
- 高齢大腿骨頸部骨折患者の機能的予後に影響する要因, 伊木 雅之, 高山成子, Environmental Health and Preventive Medicine, Environmental Health and Preventive Medicine, 6, 1, 47, 53, 2001年04月
- 閉経後女性のライフスタイル要因からみた骨粗鬆症予防対策に関する研究, 伊木 雅之, 梶田 悦子, 北陸公衆衛生学会誌, 北陸公衆衛生学会誌, 27, 2, 118, 123, 2001年
- 大腿骨頸部骨折を起こした日本人高齢者の死亡率とその予後因子, 高山 成子, 伊木 雅之, Environmental Health and Preventive Medicine, Environmental Health and Preventive Medicine, 5, 4, 160, 166, 2001年01月
- 第二次性徴期の10歳代健常日本人男女における前腕骨骨密度の標準値, 松倉 知晴, 伊木 雅之, 鏡森 定信, 山上 孝司, Osteoporos International, Osteoporos International, 11, 10, 858, 865, 2000年10月
- 中国内モンゴールにおける閉経前女性のビタミンD受容体遺伝子多型と手骨骨密度との関連, 劉 仲玉, 伊木 雅之, 畢 力夫, 民族衛生, 民族衛生, 66, 4, 175, 183, 2000年07月
- 中国内モンゴールの都市部, 農村部および草原部における閉経前女性の骨粗鬆症関連要因の比較研究 : 生活習慣, 第2中手骨骨量および骨代謝マーカーの関連を中心に, 劉 仲玉, 畢 力夫, 梶田 悦子, 西野 治身, 伊木 雅之, 新村 哲夫, 関根 道和, 島 茂, 張 〓, 桑守 豊美, 原田 澄子, 鏡森 定信, 民族衞生, 民族衞生, 66, 1, 14, 27, 2000年01月31日
概要：One hundred and sixteen community-dwelling premenoposal women aged 35-49 in Inner Mongolia (36 from a city, 39 from a farming village and 41 from a grassland community) were recruited for participation in a study to investigate osteoporosis-related factors. The bone mineral density (BMD) was measured by computed X-ray densitometry (CXD). Hand bone X-rays were taken with an aluminum step-wedge ruler. Anthropometric and several lifestyle data, including workload, exercise, milk drinking, smoking and nutrient intake, were also measured. Markers of bone metabolism, 1, 25 (OH)2D3 and fluoride in drinking water and urine samples were measured. Body height and grip strength were the highest in the city subjects. There were no significant differences in body weight and body mass index (BMI) among the three groups. The percentage of the subjects who were engaged in heavy or moderate workloads was the highest in the village subjects. The village subjects had the lowest percentages of habits of both regular exercise and milk drinking . The percentage of subjects with smoking habit was the highest in the village group. Intakes of calcium and animal protein were the lowest in the village group probably because their diets were mainly composed of grains and vegetables . For both non-dominant and dominant hands, however, the BMD of the second metacarpus were the highest in this group. Univariate logistic regression analysis demonstrated that the subjects who experienced moderate-heavy workload in their 20s and in the present time and those whose grip strength exceeded the average level had significantly higher BMD of non-dominant hand than the remainders, respectively. Multivariate stepwise logistic regression analysis also showed siginificant effects of workload and grip strength on BMD. The levels of bone-alkaline phosphatase (B-Alp) as a marker of bone formation and crosslaps (CL/Cr) as a marker of bone resorption were the highest in the grassland group. The level of 1, 25 (OH)2D3 was about 1.5 times higher in the grassland group compared with the city and village groups. Furthermore, the concentration of fluoride in drinking water and urine samples were about 5 times higher in the grassland group than other two groups . In the grassland group, concentration of fluoride in urine was positively correlated with B-Alp (r=0.34, p<0.05) and CL/Cr (r=0.39, p<0.05), respectively. These findings suggest that high workload and grip strength play important roles on BMD among women living in farming village of Inner Mongolia. Despite higher milk intake, the biological markers of bone metabolism among the grassland subjects showed postmenopausal pattern, suggesting the effects of high fluoride level in drinking water.
- 膀胱移行上皮癌におけるサイクリンEの過剰発現, 槙山 和秀, 伊木 雅之, 増田 光伸, Cancer Letters, Cancer Letters, 151, 193, 198, 2000年
- 腎盂尿管移行上皮癌におけるサイクリン依存性キナーゼ阻害物質p27kipⅠの発現, 増田 光伸, 伊木 雅之, 高野 康雄, Cancer Letters, Cancer Letters, 150, 183, 189, 2000年
- 企業規模ならびに業種からみた高血圧の有所見率に関する研究 : 福井県内事業所健診結果の解析, 平井 一芳, 日下 幸則, 伊木 雅之, 出口 洋二, 佐藤 一博, 海野 浩輔, 河原 和夫, 日本公衆衛生雑誌, 日本公衆衛生雑誌, 43, 9, 806, 814, 1996年09月15日
- 糖尿病妊婦の奇形児出産に関する疫学的研究, 田邊 美智子, 森田 明美, 日下 幸則, 伊木 雅之, 佐藤 一博, 豊田 長康, 杉山 隆, 出口 月雄, 日本産科婦人科學會雜誌, 日本産科婦人科學會雜誌, 48, 2, 103, 110, 1996年02月01日
概要：妊娠24週以降の単胎分娩について, 糖尿病妊婦における奇形児出産の相対危険度, および糖尿病妊婦の奇形児発生に関連するリスク要因を臨床疫学的に明らかにすることが本研究の目的である. 三重大学医学部附属病院産科において, 1979年1月から1992年12月までの14年間に出産した妊婦4,353例を調査対象とした. 分娩台帳に奇形児出産の記載のあった妊婦は110例(2.5%)であった. 糖尿病合併と判定されたものは103例で, うち, 身長, 体重, 糖尿病発見時年齢, 血糖値, Hemoglobin A_1(HbA_1)値等の検査値の記載がある71例(68.9%)を対象として奇形児発生のリスク要因を検討した. 糖尿病合併妊婦における奇形児出産率は9.7%と全妊婦に比し有意に高率で, 奇形児出産の相対危険度は非糖尿病妊婦に比し4.6倍と高かった. また, 糖尿病合併妊婦における奇形児出産群(奇形群)では帝王切開や周産期死亡の既往の頻度が有意に高く, 分娩時年齢, 在胎週数, 出生体重, 母体の妊娠中の体重増加のいずれも非奇形児出産群(非奇形群)に比し有意に低値を示した. 多重ロジスティック回帰モデルを用いた糖尿病妊婦の奇形児発生リスクの検討では, 分娩時年齢, 在胎週数, 出生体重, 糖尿病発見時年齢, 分娩歴, HbA_1値(>9%)がリスク要因として有意であった. また分娩時年齢と糖尿病発見時年齢に有意の正の相関, 糖尿病罹患年数と分娩時年齢および糖尿病発見時年齢との間にはそれぞれ有意の負の相関が認められた. さらに糖尿病罹患年数が短いものほど血糖コントロールが不良で, 奇形児出産率が高いことが明らかとなった.
- 明治時代から昭和時代まで-小学校で観察した学童児の体格と肥満の推移に関する研究, 田邊 美智子, 海野 浩輔, 佐藤 一博, 日下 幸則, 森田 明美, 伊木 雅之, 須藤 正克, 高橋 佳子, 川崎 幸枝, 高橋 義正, 日本衞生學雜誌, 日本衞生學雜誌, 50, 5, 952, 958, 1995年12月15日
概要：Data on height and weight were collected at an elementary school in Fukui Prefecture from 1889 through 1934 (observation period). During the observation period, the school area, consisting of a mountainous region and a plain region, was not changed. Using these data, analysis showed that there were: (1) differences in physique between children from the mountainous region and those from the plain region, which was suggested by the school teachers during the observation period, (2) chronological changes in physique, (3) chronological changes in the features of the height velocity curve in the analysis when school children at the same school born in the 1980s were used as a control, (4) chronological changes in the balance of weight to height and (5) changes in the prevalence of obesity.<BR>The results were as follows:<BR>(1) during the observation period, the physiques of children in the mountainous region were consistently inferior to those in the plain region, (2) during the period, the average physique of the school children aged 12 was consistently inferior to the overall average for Japanese pupils of the same age, (3) during the observation period, the onset of the adolescent growth spurt was later by one year compared with that of current controls, (4) the ratio of weight to height stratified by 3cm intervals during the observation period was almost the same as that in current controls, (5) during the observation period, the prevalence of obesity in boys (6%) was lower than that in current controls (10%). However, the obesity prevalence in girls during the period was higher than that in the controls. However, this findings might be associated with wearing kimono during measurement.<BR>By contrast, these differences have recently disappeared. These results suggest that there were consistent differences in physique that persisted between regions in the school area and in Japan as a whole across several eras.
- 最大酸素摂こそ量と循環器疾患リスク・ファクターとし関係-横断的解析結果-, 飛田 芳江, 大滝 秀穂, 日下 幸則, 伊木 雅之, 梶田 悦子, 佐藤 一博, 産業衛生学雑誌 = Journal of occupational health, 産業衛生学雑誌 = Journal of occupational health, 37, 6, 409, 415, 1995年11月20日
- 中高年女性の腰椎骨密度とそれに影響する要因(第3報) 有経者と閉経者にみた体力指標及びLifestyle要因と骨密度との関係, 梶田 悦子, 伊木 雅之, 飛田 芳江, 三田村 純枝, 日下 幸則, 緒方 昭, 寺本 路夫, 土田 千賀, 山本 和高, 石井 靖, 日本衞生學雜誌, 日本衞生學雜誌, 50, 4, 893, 900, 1995年10月15日
概要：We recruited community-dwelling women for participation in a study to investigate the effects of risk factors in lifestyle on bone mineral density (BMD). The subjects were 177 women aged 35 years and over living in a rural area in Fukui Prefecture. Their BMD of the lumbar spine (L2-L4) was determined by dual energy X-ray absorptiometry (DXA). In addition to measurements of height, body weight and grip strength, the lifestyles of the women, including physical load in work, sporting activities, smoking habits, calcium intake, and history of bone fracture were interviewed in detail.Adjusted for age, the BMD significantly correlated to body weight (r=0.337, p<0.05 for premenopausal women and r=0.289, p<0.01 for postmenopausal women) and body mass index (kg/m2) (r=0.291, p<0.05 for premenopausal women and r=0.190, p<0.05 for postmenopausal women). These results indicated the lower body weight to be a risk factor for the osteoporotic process in middle-aged and aged women. With respect to the grip strength as a physical fitness indicator, a significant correlation coefficient (r=0.267, p<0.01) with BMD was obtained for postmenopausal women independent of age and body weight.In univariate analysis, BMD showed no significant correlations with sporting activities, smoking habits, lower back pain and history of bone fracture for either premenopausal women or postmenopausal women. In multiple regression analysis using age, calcium intake, physical load in work, body weight, grip strength, and sporting activities, the latter three variables had significantly increasing effects on BMD, while aging and menopause had significantly negative effects on BMD.Thus, physical excercise was suggested to protect middle-aged and aged women from the osteoporotic process, probably through either maintaining or enhancing muscle strength.
- 中高年女性の腰椎骨密度とそれに影響する要因 (第2報) 骨代謝の生化学指標からみた年齢および閉経の骨密度への影響, 西野 治身, 田中 朋子, 土肥 祥子, 伊木 雅之, 梶田 悦子, 日下 幸則, 鏡森 定信, 日本衞生學雜誌, 日本衞生學雜誌, 49, 4, 807, 815, 1994年10月15日
概要：Bone mineral density of the lumbar spine (BMD) and biochemical markers for bone turnover were examined to study the mechanisms of age-related and menopause-related bone loss. We measured BMD of the lumbar spine and serum bone alkaline phosphatase (B-AlP) and bone gla-protein (BGP) as markers of bone formation and fasting urinary creatinine-adjusted hydroxyproline (Hyp/Cr) and calcium (Ca/Cr) as those of bone resorption in 166 community-dwelling Japanese women.A highly significant positive correlation between age and each of the biochemical markers, except for Ca/Cr, was observed. This relationship was not linear. Marked elevation in the levels of the markers was found in women in their sixth decade women compared with those in their fifth.All the markers correlated inversely with the BMD and these relationships remained significant after elimination of the effect of age by partialization. When analyzing the subjects in each five-year age group, the positive correlation of Hyp/Cr with Ca/Cr was significant in the subjects aged 45 to 49 and the negative correlation of Hyp/Cr with BMD was significant in those aged 50 to 54. B-AlP correlated positively with BGP in the subjects aged between 50 and 54 and inversely with BMD in those aged between 55 and 59. These correlations were significant. Thus, intercorrelations between the markers were observed five years earlier than were correlations between the markers and BMD. Such associations appeared earlier in terms of the markers for bone resorption than in terms of the markers for bone formation.In the subjects aged 50 to 54 who had encountered menopause more than three years previously, BGP and Hyp/Cr were elevated compared with those in the premenopausal women of similar age and a significant correlation between Hyp/Cr and BMD was observed. Therefore, menopause seemed to account for the uncoupled activation in the bone metabolism found in the subjects around 50 years of age.The decrease in bone mass observed in our subjects around 50 years of age as a result of uncoupling of bone formation and resorption was suggested to be initiated by activation of bone resorption caused by menopause preceding activation of bone formation.
- 中高年女性の腰椎骨密度とそれに影響する要因(第1報)腰椎骨密度のDual-energy X-ray absorptiometryによる測定成績と年齢,閉経の影響, 梶田 悦子, 伊木 雅之, 西野 治身, 土肥 祥子, 森山 忠重, 飛田 芳江, 出口 洋二, 日下 幸則, 緒方 昭, 日本衞生學雜誌, 日本衞生學雜誌, 49, 3, 674, 683, 1994年08月15日
概要：Bone mineral density (BMD) of the lumbar spine in 198 community-dwelling Japanese women aged 35 years and over was measured by dual-energy X-ray absorptiometry to investigate the effects of aging and menopause on BMD.A highly significant negative correlation between age and BMD was observed in postmenopausal women as widely accepted. We found a weak but statistically significant negative correlation between age and BMD in even premenopausal women, suggesting that their bone loss had commenced before menopause. Marked decrement in BMD was seen during the first ten years after menopause. Menopause clearly accelerated bone loss in the lumbar spine. Two-way analysis of variance of BMD on age and menopausal status showed that these explanatory variables had a significantly decreasing effect on BMD independently of each other. Menopausal status had a greater sum of squares than age, which suggested that menopause played a greater role in bone loss than did aging. Early menopause has been implied as one of the risk factors for bone loss. The women aged 50 to 59 having encountered menopause before 49 years old exhibited significantly lower BMD than those of similar age who experienced menopause at age 49 and older. This difference in BMD was not observed in the women aged 60 and over. Early menopause was no more likely to be a risk factor for bone loss in the elderly wonen.We conclude that bone loss in the lumbar spine begins before menopause and is accelerated markedly by menopause for about ten years, and that menopause has a greater decreasing effect on the bone mass than does chronological age while each of them has an independent effect on the bone mass decrement.
