The antiviral and antibacterial properties of ozone gas have been utilised for air and on-site disinfection. However, excess ozone gas exposure is toxic to humans, necessitating the monitoring of exposure levels. While this has been achieved using ozone indicators, determining exposure levels at intermediate time points during exposure remains challenging owing to the current ones being capable of measuring exposure only at endpoints. Shifts in the endpoint are also difficult as the coverage ranges of the indicators are dependent on a single colour dye. The indicator that covers a wide range is desirable to treat various pathogenic microorganisms. The aim of this study was to develop a two-colour ozone indicator with a broad coverage range that does not compromise the performance of the individual dyes. Exposure levels were indicated by visible changes in colour density and phase, aiding the measurement of exposure at the endpoints and during the exposure period, thereby maintaining better safety profiles for exposed individuals. Additionally, a theoretical approach for the development of two-colour indicators has been described.

On-site disinfection techniques are beneficial during a pandemic when there is a marked shortage of personal protective equipment (PPE), as experienced during the coronavirus disease 2019 outbreak. Ozone gas has been considered an alternative on-site disinfectant during a pandemic because it has antimicrobial activities, can be produced from air by electricity without the need for storage, and can be easily deactivated after use. However, ozone gas might become distributed at the lower layer because it has a larger molecular weight than air. This study aimed to reveal the applicability of ozone gas for the on-site disinfection of PPE. The lockers meant for changing dresses were used as ozone gas exposure boxes, and the distribution of ozone was assayed. Considering that the determined ozone levels were not consistent in the types of ozone analysers, we studied the chemical and biological activities of ozone, which were evenly detected in the locker. The gown in the locker was also uniformly exposed to ozone. Results showed that ozone gas could be used for the on-site disinfection of PPE in a closed box, such as a locker. This finding is valuable during a pandemic when PPE is in short supply.

BACKGROUND: Exposure to anticancer drugs is hazardous and may lead to chromosomal abnormalities and spontaneous abortion in healthcare workers. Guidelines recommend surface decontamination and cleaning in order to minimize the occupational exposure to anticancer drugs, although no single process has been found to deactivate all currently available hazardous drugs. Ozone gas is oxidative and a decontaminant for bacteria; its characteristic as a gas has advantages in that it does not need to be wiped off or neutralized after use. METHODS: The nucleoside anticancer drugs, cytarabine and fluorouracil, were exposed to ozone gas on plates under controlled humidity. The levels of exposed ozone were evaluated using the concentration-time (CT) value, which is the mathematical product of ozone concentration and exposure time. The effects of exposure to ozone on levels of the anticancer drugs were determined by high-performance liquid chromatography (HPLC). RESULTS: The levels of cytarabine decreased with increasing CT value and were not detected beyond 40,000 CT. The decomposition levels of the anticancer drug by ozone were CT-dependent irrespective of the maximum concentration of ozone. Higher humidity in the range from 70 to 90 % accelerated the decomposition of cytarabine and fluorouracil, and neither of the drugs were detected at 90 % humidity after exposure to ozone gas. CONCLUSIONS: Ozone gas decomposed these nucleoside anticancer drugs. This is the first report of the applicability of ozone gas as a decontaminator for anticancer drugs.

国立循環器病センターにおける心筋梗塞症に対する薬物療法についての処方実態調査し、使用薬剤の傾向について考察した。

主な循環器用薬における臨床で注意すべき腎機能障害時の投与方法について解説

主な循環器用薬における臨床で注意すべき薬物相互作用について解説

薬学教育モデル・コアカリキュラムに沿った実習の実施状況を検証し、6年制長実務実習の問題点の検討と改善を目的に学生アンケートを実施した。アンケート結果は、薬学教育において改善項目の抽出などに使用されている顧客満足度(CS)分析より検討した。病院実務実習の実習内容は、「TDMについての演習あるいは実習を受けましたか?」が「要改善項目」として抽出され、薬局実務実習の実習内容は、「薬品管理に関する説明を受けましたか?」が「要改善項目」として抽出された。また、実務実習の指導にあたる指導薬剤師に関しては病院薬局共に、「指導薬剤師の言動に不快だと感じたことがありましたか?」が「改善検討項目」として抽出された。言動は実務実習を円滑に遂行する上で非常に重要かつ基本的な問題で、大学教員と実習指導薬剤師がワークショップなどで共にコミュニケーションとは何かを学び、スキルを検討する必要があった。

アミオダロン注の血中濃度推移の検討

国立循環器病センターにおける心筋梗塞症に対する薬物療法についての処方実態調査し、使用薬剤の傾向について考察

国立循環器病センターにおける心筋梗塞症に対する薬物療法についての処方実態調査し、使用薬剤の傾向について考察

処方オーダリングシステムに導入した新規医療事故防止対策について概説

本研究は急変患者に接する可能性の高い病院・薬局勤務薬剤師が、救急領域においてどのような知識や技術を必要としているかを抽出し救急認定薬剤師養成を見据えた薬剤師に特化したICLSコースの開発と評価を検討することを目的とした。 初年度においては病院、薬局173施設に、薬剤師業務での必要な救急知識や技術の内容、および理解度を個人が特定されない統計的回答形式のアンケートを送付し、解析を実施した。その結果を踏まえたICLSコースを「薬剤師のための患者急変時対応講習会」として、6回開催、54名の薬剤師が受講した。そのコース内容の評価、および受講者の知識や技術の改善度を調査解析し研究成果を報告した。