 | KATO MaikoDepartment of Medicine Lecturer | ||
Last Updated :2024/04/25
Published Papers
- Chisa Nakashima; Maiko Kato; Atsushi OtsukaThe Journal of Dermatology Wiley 50 (3) 280 - 289 0385-2407 2023/01Abstract In December 2019, a new infectious pathogen named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was identified in Wuhan, China. Transmitted through respiratory droplets, SARS‐CoV‐2 is the causative pathogen of coronavirus disease 2019 (COVID‐19). Although this new COVID‐19 infection is known to cause primarily interstitial pneumonia and respiratory failure, it is often associated with cutaneous manifestations as well. These manifestations with COVID‐19 can be classified into seven categories: (i) chilblain‐like skin eruption (e.g., COVID toes), (ii) urticaria‐like skin eruption, (iii) maculopapular lesions, (iv) vesicular eruptions, (v) purpura, (vi) livedo reticularis and necrotic lesions, (vii) urticarial vasculitis, and others such as alopecia and herpes zoster. The pathogenesis of skin eruptions can be broadly divided into vasculitic and inflammatory skin eruptions. Various cutaneous adverse reactions have also been observed after COVID‐19 mRNA vaccination. The major cutaneous adverse reactions are type I hypersensitivity (urticaria and anaphylaxis) and type IV hypersensitivity (COVID arm and erythema multiform). Autoimmune‐mediated reactions including bullous pemphigus, vasculitis, vitiligo, and alopecia areata have also been reported. Several cases with chilblain‐like lesions and herpes zoster after COVID‐19 mRNA vaccination have been published. Various skin diseases associated with COVID‐19 and COVID‐19 vaccination have been reported, and the mechanism has been partly elucidated. In the process, for example, some papers have reported that it is not related to COVID‐19 infection, although it was initially called COVID‐toe and considered a COVID‐19‐associated cutaneous eruption. In fact, some COVID‐19‐associated skin reactions are indistinguishable from drug eruptions. In the future, the mechanisms of COVID‐19‐ or COVID‐19 vaccine‐associated skin reactions need to be elucidated and verification of causal relationships is required.
- 岩津 理世; 佐藤 雅子; 加藤 麻衣子; 柳原 茂人; 大磯 直毅; 川田 暁; 大塚 篤司皮膚の科学 日本皮膚科学会-大阪地方会・京滋地方会 21 (2) 108 - 113 1347-1813 2022/0652歳,男性。7年前に尋常性天疱瘡と診断され当科に通院していたが,背部の皮膚と両側頬粘膜のびらんが徐々に増悪したため入院となった。入院時のPemphigus Disease Area Index(PDAI)は皮膚10点,粘膜2点と中等症であったが難治であり,入院後激しい咽頭痛,呼吸困難感が生じ上部消化管内視鏡検査を施行したところ,食道全長にわたって粘膜びらん・潰瘍・裂創を認めた。抗デスモグレイン1抗体630U/mL,抗デスモグレイン3抗体2,540U/mLと上昇を認め,さらに粘膜びらんと潰瘍が食道全体に散発していたため,尋常性天疱瘡の食道粘膜病変と考え,ステロイドパルス療法,全身投与,免疫抑制剤内服,血漿交換療法,免疫グロブリン大量静注療法を行ったところ,皮膚症状と口腔内粘膜症状は改善した。上部消化管内視鏡検査にて食道全長に生じた粘膜病変の改善も確認し,治療効果判定もおこなった。自験例では入院時のは皮膚10点,粘膜2点と中等症であったが難治であり,重度の食道粘膜症状もきたした。口腔粘膜病変を伴う場合,上部消化管内視鏡検査で食道粘膜病変の観察を行うこと,重症例においては積極的に初期治療を行うことが重要であると考える。(著者抄録)
- 岩津 理世; 佐藤 雅子; 加藤 麻衣子; 柳原 茂人; 大磯 直毅; 立石 千晴; 橋本 隆; 鶴田 大輔; 川田 暁; 大塚 篤司皮膚の科学 日本皮膚科学会-大阪地方会・京滋地方会 21 (2) 126 - 132 1347-1813 2022/0677歳,男性。初診の1週間前から手足に紅斑と水疱を認めた。その後皮疹が全身に拡大し,粘膜にもびらんを認めたため,精査加療目的で当科に紹介された。初診時,体幹・四肢に紅斑と水疱が多発しており,口唇・口腔内・陰茎にびらんを認めた。抗BP180-NC16A部位抗体,抗デスモグレイン1,3抗体は陰性であった。病理組織にて好酸球浸潤を伴う表皮下水疱,蛍光抗体直接法で表皮基底膜部にC3の線状沈着を認めた。1M食塩水剥離皮膚を基質とした蛍光抗体間接法では,IgG抗体が真皮側に反応した。正常ヒト真皮抽出液を用いた免疫ブロット法にて患者血清IgG抗体は200kDaラミニンγ1(p200)に反応し,ラミニン332リコンビナント蛋白を用いた免疫ブロット法で165kDaラミニンα3に反応した。臨床症状と病理所見,蛍光抗体直接法,蛍光抗体間接法,免疫ブロット法の結果より,抗ラミニンγ1類天疱瘡と抗ラミニン332型粘膜類天疱瘡の合併と診断した。プレドニゾロン1mg/kg/日点滴を行ったところ,新生水疱を認めなくなり,紅斑は退色,びらんは上皮化した。その後,プレドニゾロンを漸減したが,皮膚・粘膜症状は再燃しなかった。自験例では皮膚・粘膜症状は重篤であったが,ステロイド全身投与が速やかに奏効した。(著者抄録)
- 廣田 菜々子; 鈴木 緑; 加藤 麻衣子; 柳原 茂人; 遠藤 英樹; 大磯 直毅; 川田 暁; 大塚 篤司; 田中 薫; 藤田 岳皮膚の科学 日本皮膚科学会-大阪地方会・京滋地方会 21 (1) 1 - 5 1347-1813 2022/0364歳,女性。初診の1年前に右外耳道癌と診断され,右外側側頭骨切除術,術後放射線療法ならびに化学療法を施行していた。術後1年後に右外耳道癌の再発を認めたため,ニボルマブ投与開始となった。開始後12日後より口唇びらんが出現し,四肢・体幹に紅斑が拡大したため,当科紹介受診となった。臨床症状,病理組織所見よりニボルマブによるStevens-Johnson症候群と診断した。ステロイドパルス療法,血漿交換,免疫グロブリン大量静注療法にて改善した。ニボルマブに関連する有害事象の重症化を防ぐためには早期の治療介入や集学的治療が必要であり,今後同様の症例報告の集積が望まれる。(著者抄録)
- 食道全長にわたって粘膜びらん・潰瘍を呈した尋常性天疱瘡の1例岩津 理世; 鈴木 緑; 内田 修輔; 加藤 麻衣子; 柳原 茂人; 遠藤 英樹; 大磯 直毅; 川田 暁西日本皮膚科 日本皮膚科学会-西部支部 83 (3) 252 - 252 0386-9784 2021/06
- Yanagihara S; Oiso N; Morita Y; Miyake Y; Kato M; Matsumura I; Kawada AThe Journal of dermatology 0385-2407 2019/11 [Refereed]
- Yanagihara S; Oiso N; Hirota N; Kato M; Miyake S; Kawada AEuropean journal of dermatology : EJD 29 (3) 332 - 333 1167-1122 2019/06 [Refereed]
- Kato M; Oiso N; Uchida S; Yanagihara S; Sano H; Tohda Y; Kawada AThe Journal of dermatology 46 (7) e230 - e232 0385-2407 2019/02 [Refereed]
- PUVA療法で寛解したfolliculotrophic mycosis fungoidesの1例鈴木 緑; 立林めぐ美; 加藤麻衣子; 栁原茂人; 大磯直毅; 川田 暁皮膚の科学 17 (5) 265 - 269 2018/10 [Refereed]
- 鈴木 緑; 立林めぐ美; 三宅雅子; 加藤麻衣子; 柳原茂人; 大磯直毅; 川田 暁; 松尾仁子皮膚の科学 17 (2) 70 - 74 2018/04 [Refereed]
- Maiko Kato; Sachiyo Tsuji-Kawahara; Yuri Kawasaki; Saori Kinoshita; Tomomi Chikaishi; Shiki Takamura; Makoto Fujisawa; Akira Kawada; Masaaki MiyazawaJOURNAL OF VIROLOGY AMER SOC MICROBIOLOGY 89 (2) 1468 - 1473 0022-538X 2015/01 [Refereed]
Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4(+) T cells. - Naoki Oiso; Maiko Kato; Akira KawadaEUROPEAN JOURNAL OF DERMATOLOGY JOHN LIBBEY EUROTEXT LTD 24 (6) 688 - 689 1167-1122 2014/12 [Refereed]
- Maiko Kato; Naoki Oiso; Yuji Nozaki; Asuka Inoue; Yuji Hosono; Masanori Funauchi; Tsuneyo Mimori; Itaru Matsumura; Akira KawadaJOURNAL OF DERMATOLOGY WILEY-BLACKWELL 41 (11) 1034 - 1036 0385-2407 2014/11 [Refereed]
- Oiso N; Kato M; Kawada AEuropean journal of dermatology : EJD 24 (5) 617 - 618 1167-1122 2014/09 [Refereed]
- Maiko Kato; Naoki Oiso; Mitsuhisa Nishimoto; Yasunori Mori; Yoshinari Katoh; Hirotsugu Uemura; Akira KawadaEUROPEAN JOURNAL OF DERMATOLOGY JOHN LIBBEY EUROTEXT LTD 24 (5) 622 - 623 1167-1122 2014/09 [Refereed]
- 加藤 麻衣子; 三宅 宗晴; 大磯 直毅; 川田 暁; 露口 一成皮膚の科学 日本皮膚科学会-大阪地方会・京滋地方会 13 (3) 172 - 175 1347-1813 2014/0682歳,女性。数年前より右頬部に軽度そう痒を伴う皮疹が出現し,徐々に拡大してきた。初診時,右頬部に鱗屑と痂皮が付着する直径6×4cm大の境界比較的明瞭な紅斑局面を認めた。生検標本の病理組織検査で,乾酪壊死はなかったがリンパ球浸潤を伴った類上皮細胞肉芽腫を認めた。クオンティフェロンTBゴールドは陽性を示した。病理組織のZiehl-Neelsen染色で抗酸菌を認めなかった。生検皮膚からの結核菌DNAのPCRは陰性であった。しかし生検皮膚からMycobacterium tuberculosisが分離培養され,尋常性狼瘡と診断した。喀痰培養,胸部CTを施行したが活動性の肺病変はなかった。臨床症状や病理所見より尋常性狼瘡の可能性を考えた際には,さまざまな検査法を用いて抗酸菌の存在を証明する必要があると考えた。(著者抄録)
- Maiko Kato; Naoki Oiso; Tatsuki Itoh; Masako Sato; Kazuhiko Matsuo; Takashi Nakayama; Takao Satou; Akira KawadaJOURNAL OF DERMATOLOGY WILEY-BLACKWELL 41 (5) 459 - 461 0385-2407 2014/05 [Refereed]
- アダリムマブ投与後に発症した抗PL-12抗体陽性皮膚筋炎の1例加藤 麻衣子; 大磯 直毅; 川田 暁; 井上 明日圭; 野崎 祐史; 船内 正憲日本皮膚科学会雑誌 (公社)日本皮膚科学会 124 (4) 802 - 802 0021-499X 2014/04
- Shiki Takamura; Eiji Kajiwara; Sachiyo Tsuji-Kawahara; Tomoko Masumoto; Makoto Fujisawa; Maiko Kato; Tomomi Chikaishi; Yuri Kawasaki; Saori Kinoshita; Manami Itoi; Nobuo Sakaguchi; Masaaki MiyazawaPLOS PATHOGENS PUBLIC LIBRARY SCIENCE 10 (3) e1003937 1553-7366 2014/03 [Refereed]
In chronic viral infections, persistent antigen presentation causes progressive exhaustion of virus-specific CD8(+) T cells. It has become clear, however, that virus-specific naive CD8(+) T cells newly generated from the thymus can be primed with persisting antigens. In the setting of low antigen density and resolved inflammation, newly primed CD8(+) T cells are preferentially recruited into the functional memory pool. Thus, continual recruitment of naive CD8(+) T cells from the thymus is important for preserving the population of functional memory CD8(+) T cells in chronically infected animals. Friend virus (FV) is the pathogenic murine retrovirus that establishes chronic infection in adult mice, which is bolstered by the profound exhaustion of virus-specific CD8(+) T cells induced during the early phase of infection. Here we show an additional evasion strategy in which FV disseminates efficiently into the thymus, ultimately leading to clonal deletion of thymocytes that are reactive to FV antigens. Owing to the resultant lack of virus-specific recent thymic emigrants, along with the above exhaustion of antigen-experienced peripheral CD8(+) T cells, mice chronically infected with FV fail to establish a functional virus-specific CD8(+) T cell pool, and are highly susceptible to challenge with tumor cells expressing FV-encoded antigen. However, FV-specific naive CD8(+) T cells generated in uninfected mice can be primed and differentiate into functional memory CD8(+) T cells upon their transfer into chronically infected animals. These findings indicate that virus-induced central tolerance that develops during the chronic phase of infection accelerates the accumulation of dysfunctional memory CD8(+) T cells. - Sachiyo Tsuji-Kawahara; Tomomi Chikaishi; Eri Takeda; Maiko Kato; Saori Kinoshita; Eiji Kajiwara; Shiki Takamura; Masaaki MiyazawaJOURNAL OF VIROLOGY AMER SOC MICROBIOLOGY 84 (12) 6082 - 6095 0022-538X 2010/06 [Refereed]
Several host genes control retroviral replication and pathogenesis through the regulation of immune responses to viral antigens. The Rfv3 gene influences the persistence of viremia and production of virus-neutralizing antibodies in mice infected with Friend mouse retrovirus complex (FV). This locus has been mapped within a narrow segment of mouse chromosome 15 harboring the APOBEC3 and BAFF-R loci, both of which show functional polymorphisms among different strains of mice. The exon 5-lacking product of the APOBEC3 allele expressed in FV-resistant C57BL/6 (B6) mice directly restricts viral replication, and mice lacking the B6-derived APOBEC3 exhibit exaggerated pathology and reduced production of neutralizing antibodies. However, the mechanisms by which the polymorphisms at the APOBEC3 locus affect the production of neutralizing antibodies remain unclear. Here we show that the APOBEC3 genotypes do not directly affect the B-cell repertoire, and mice lacking B6-derived APOBEC3 still produce FV-neutralizing antibodies in the presence of primed T helper cells. Instead, higher viral loads at a very early stage of FV infection caused by either a lack of the B6-derived APOBEC3 or a lack of the wild-type BAFF-R resulted in slower production of neutralizing antibodies. Indeed, B cells were hyperactivated soon after infection in the APOBEC3- or BAFFR-deficient mice. In contrast to mice deficient in the B6-derived APOBEC3, which cleared viremia by 4 weeks after FV infection, mice lacking the functional BAFF-R allele exhibited sustained viremia, indicating that the polymorphisms at the BAFF-R locus may better explain the Rfv3-defining phenotype of persistent viremia. - Shiki Takamura; Sachiyo Tsuji-Kawahara; Hideo Yagita; Hisaya Akiba; Mayumi Sakamoto; Tomomi Chikaishi; Maiko Kato; Masaaki MiyazawaJOURNAL OF IMMUNOLOGY AMER ASSOC IMMUNOLOGISTS 184 (9) 4696 - 4707 0022-1767 2010/05 [Refereed]
During chronic viral infection, persistent exposure to viral Ags leads to the overexpression of multiple inhibitory cell-surface receptors that cause CD8(+) T cell exhaustion. The severity of exhaustion correlates directly with the level of infection and the number and intensity of inhibitory receptors expressed, and it correlates inversely with the ability to respond to the blockade of inhibitory pathways. Friend virus (FV) is a murine retrovirus complex that induces acute high-level viremia, followed by persistent infection and leukemia development, when inoculated into immunocompetent adult mice. In this article, we provide conclusive evidence that FV infection results in the generation of virus-specific effector CD8(+) T cells that are terminally exhausted. Acute FV-induced disease is characterized by a rapid increase in the number of virus-infected erythroblasts, leading to massive splenomegaly. Most of the expanded erythroblasts strongly express programmed death ligand-1 and MHC class I, thereby creating a highly tolerogenic environment. Consequently, FV-specific effector CD8(+) T cells uniformly express multiple inhibitory receptors, such as programmed cell death 1 (PD-1), T cell Ig domain and mucin domain 3 (Tim-3), lymphocyte activation gene-3, and CTLA-4, rapidly become nonresponsive to restimulation and are no longer reinvigorated by combined in vivo blockade of PD-1 and Tim-3 during the memory phase. However, combined blockade of PD-1 and Tim-3 during the priming/differentiation phase rescued FV-specific CD8(+) T cells from becoming terminally exhausted, resulting in improved CD8(+) T cell functionality and virus control. These results highlight FV's unique ability to evade virus-specific CD8(+) T cell responses and the importance of an early prophylactic approach for preventing terminal exhaustion of CD8(+) T cells. The Journal of Immunology, 2010, 184: 4696-4707. - Miyazawa, M; S. Tsuji-Kawahara; T. Chikaishi; M. Kato; S. TakamuraRetrovirology 6 (Suppl 2) O9 2009
Conference Activities & Talks
- 遺伝性ポルフィリン症に対する新規光線防御剤の有用性(第3報) [Not invited]加藤 麻衣子; 川田 暁; 川原 繁; 上出 良一; 浅野 新; 寺村 崇日本皮膚科学会雑誌 2014/08
- アダリムマブ投与後に発症した抗PL-12抗体陽性皮膚筋炎の1例 [Not invited]加藤 麻衣子; 大磯 直毅; 川田 暁; 井上 明日圭; 野崎 祐史; 船内 正憲日本皮膚科学会雑誌 2014/04
- 脂肪類壊死の1例 [Not invited]加藤 麻衣子; 吉田 益喜; 大磯 直毅; 川田 暁日本皮膚科学会雑誌 2014/04
- 尋常性狼瘡の1例 [Not invited]加藤 麻衣子; 三宅 宗晴; 栗本 貴弘; 大磯 直毅; 吉田 益喜; 川田 暁; 露口 一成皮膚の科学 2013/02
- Infection of thymus with murine retrovirus induces virus-specific central tolerance that prevents dynamic differentiation of functional memory CD8+ T cells. [Not invited]高村 史記; 梶原 栄二; 河原 佐智代; 近石 友美; 加藤 麻衣子; 木下 さおり; 宮澤 正顯; 熊本大学大学院生命科学研究部第40回日本免疫学会総会・学術集会 2011 第40回日本免疫学会総会・学術集会
- 多発性Bowen病の1例 [Not invited]成田 智彦; 加藤 麻衣子; 山鳥 佳香; 吉永 英司; 吉田 益喜; 川原 繁; 川田 暁日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 2009/05
- 抗BP180粘膜天疱瘡の1例 [Not invited]三宅 宗晴; 吉永 英司; 加藤 麻衣子; 遠藤 英樹; 大磯 直毅; 吉田 益喜; 川原 繁; 川田 暁; 大山 文悟; 橋本 隆日本皮膚科学会雑誌 2009/04
- 悪性黒色腫と基底細胞癌を多数認めた白人男性の1例 [Not invited]門脇 麻衣子; 松田 洋昌; 成田 智彦; 吉田 益喜; 川原 繁; 川田 暁日本皮膚科学会雑誌 2008/03
- Blue toe syndromeの2例 [Not invited]門脇 麻衣子; 笹屋 晴代; 栗本 貴弘; 川原 繁; 川田 暁; 諸岡 花子; 山治 憲司; 岩永 善高; 内藤 映理皮膚の科学 2008/02
- Stevens-Johnson症候群進展型と考えられたTEN型薬疹の1例 [Not invited]遠藤 英樹; 門脇 麻衣子; 吉永 英司; 大磯 直毅; 川原 繁; 川田 暁アレルギー 2007/09
- TEN型薬疹の1例 [Not invited]門脇 麻衣子; 成田 智彦; 鈴木 高子; 吉永 英司; 遠藤 英樹; 大磯 直毅; 川原 繁; 川田 暁; 清水 祐希; 小阪 博皮膚の科学 2006/12