KINDAI UNIVERSITY


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Tomoya Takeda

Profile

FacultyDepartment of Pharmacy
PositionAssistant Professor
Degree
Commentator Guidehttps://www.kindai.ac.jp/meikan/1238-takeda-tomoya.html
URL
Mail
Last Updated :2019/06/17

Education and Career

Education

  •   2009 04  - 2011 03 , Kobe University, Graduate School of Medicine

Academic & Professional Experience

  •   2014 04 ,  - 現在, Research Associate, Kinki University

Research Activities

Research Areas

  • Pharmacy, Pharmacology in pharmacy

Research Interests

  • cancer

Published Papers

  • Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway., Tsubaki M, Takeda T, Matsumoto M, Kato N, Yasuhara S, Koumoto YI, Imano M, Satou T, Nishida S, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 40(10), 1010428318808670, Oct. 2018 , Refereed
  • Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB., Tsubaki M, Takeda T, Tomonari Y, Koumoto YI, Imano M, Satou T, Nishida S, Laboratory investigation; a journal of technical methods and pathology, Oct. 2018 , Refereed
  • RANKL-induced c-Src activation contributes to conventional anti-cancer drug resistance and dasatinib overcomes this resistance in RANK-expressing multiple myeloma cells., Mashimo K, Tsubaki M, Takeda T, Asano R, Jinushi M, Imano M, Satou T, Sakaguchi K, Nishida S, Clinical and experimental medicine, Oct. 2018 , Refereed
  • The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs., Tsubaki M, Takeda T, Tomonari Y, Mashimo K, Koumoto YI, Hoshida S, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S, Journal of cellular physiology, 233(5), 4258 - 4271, May 2018 , Refereed
  • Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3., Takeda T, Tsubaki M, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida S, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 100, 486 - 494, Apr. 2018 , Refereed
  • Pioglitazone inhibits cancer cell growth through STAT3 inhibition and enhanced AIF expression via a PPARγ-independent pathway., Tsubaki M, Takeda T, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida S, Journal of cellular physiology, 233(4), 3638 - 3647, Apr. 2018 , Refereed
  • Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins., Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S, Toxicology in vitro : an international journal published in association with BIBRA, 46, 284 - 293, Feb. 2018 , Refereed
  • Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation., Tsubaki M, Takeda T, Matsumoto M, Kato N, Asano RT, Imano M, Satou T, Nishida S, American journal of cancer research, 8(7), 1239 - 1248, 2018 , Refereed
  • Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells., Fujiwara D, Tsubaki M, Takeda T, Tomonari Y, Koumoto YI, Sakaguchi K, Nishida S, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(10), 1010428317734947, Oct. 2017 , Refereed
  • Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells., Tsubaki M, Takeda T, Kino T, Sakai K, Itoh T, Imano M, Nakayama T, Nishio K, Satou T, Nishida S, Oncotarget, 8(24), 38717 - 38730, Jun. 2017 , Refereed
  • [Influence of Next-Day Administration of Pegfilgrastim after FEC100 Chemotherapy in Japanese with Breast Cancer on Neutrophil Count]., Fujiwara D, Mashimo K, Kimura K, Noda A, Taki K, Yoshibayashi H, Takeda T, Tsubaki M, Nishida S, Sakaguchi K, Gan to kagaku ryoho. Cancer & chemotherapy, 44(2), 149 - 152, Feb. 2017 , Refereed
  • The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways., Tsubaki M, Fujiwara D, Takeda T, Kino T, Tomonari Y, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S, Clinical and experimental pharmacology & physiology, Nov. 2016 , Refereed
  • Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model., Takeda T, Tsubaki M, Sakamoto K, Ichimura E, Enomoto A, Suzuki Y, Itoh T, Imano M, Tanabe G, Muraoka O, Matsuda H, Satou T, Nishida S, Toxicology and applied pharmacology, 306, 105 - 112, Sep. 2016 , Refereed
  • RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines., Tsubaki M, Takeda T, Yoshizumi M, Ueda E, Itoh T, Imano M, Satou T, Nishida S, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37(7), 9099 - 9110, Jul. 2016 , Refereed
  • Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway., Takeda T, Tsubaki M, Kino T, Kawamura A, Isoyama S, Itoh T, Imano M, Tanabe G, Muraoka O, Matsuda H, Satou T, Nishida S, International journal of oncology, 48(6), 2704 - 2712, Jun. 2016 , Refereed
  • Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase., Takeda T, Tsubaki M, Kino T, Yamagishi M, Iida M, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S, Chemico-biological interactions, 251, 26 - 33, May 2016 , Refereed
  • Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells., Tsubaki M, Mashimo K, Takeda T, Kino T, Fujita A, Itoh T, Imano M, Sakaguchi K, Satou T, Nishida S, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 78, 23 - 29, Mar. 2016 , Refereed
  • Statins improve survival by inhibiting spontaneous metastasis and tumor growth in a mouse melanoma model., Tsubaki M, Takeda T, Kino T, Obata N, Itoh T, Imano M, Mashimo K, Fujiwara D, Sakaguchi K, Satou T, Nishida S, American journal of cancer research, 5(10), 3186 - 3197, Sep. 2015 , Refereed
  • PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects., Tsubaki M, Takeda T, Tani T, Shimaoka H, Suzuyama N, Sakamoto K, Fujita A, Ogawa N, Itoh T, Imano M, Funakami Y, Ichida S, Satou T, Nishida S, International journal of cancer. Journal international du cancer, 137(1), 243 - 250, Jul. 2015 , Refereed
  • Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells., Tsubaki M, Takeda T, Ogawa N, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Ishizaka T, Satou T, Nishida S, Leukemia research, 39(4), 445 - 452, Apr. 2015 , Refereed
  • Bisphosphonates and statins inhibit expression and secretion of MIP-1α via suppression of Ras/MEK/ERK/AML-1A and Ras/PI3K/Akt/AML-1A pathways., Tsubaki M, Takeda T, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Mashimo K, Fujiwara D, Sakaguchi K, Satou T, Nishida S, American journal of cancer research, 5(1), 168 - 179, 2015 , Refereed
  • Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2., Tsubaki M, Takeda T, Kino T, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S, American journal of translational research, 7(8), 1371 - 1381, 2015 , Refereed
  • Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP., Tsubaki M, Ogawa N, Takeda T, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Satou T, Nishida S, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 999 - 1005, Oct. 2014 , Refereed
  • Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation., Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, Shimaoka H, Takeda T, Ogawa N, Mashimo K, Fujiwara D, Mukai J, Sakaguchi K, Satou T, Nishida S, Journal of biomedical science, 21, 10, Feb. 2014 , Refereed
  • By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells., Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, Shimaoka H, Takeda T, Ogawa N, Mashimo K, Fujiwara D, Mukai J, Sakaguchi K, Satou T, Nishida S, Leukemia research, 38(1), 121 - 130, Jan. 2014 , Refereed
  • Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs., Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, Shimaoka H, Ogawa N, Mashimo K, Fujiwara D, Takeda T, Mukai J, Sakaguchi K, Satou T, Nishida S, European journal of cancer (Oxford, England : 1990), 49(17), 3708 - 3717, Nov. 2013 , Refereed
  • Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines., Tsubaki M, Komai M, Fujimoto S, Itoh T, Imano M, Sakamoto K, Shimaoka H, Takeda T, Ogawa N, Mashimo K, Fujiwara D, Mukai J, Sakaguchi K, Satou T, Nishida S, Journal of experimental & clinical cancer research : CR, 32, 62, Sep. 2013 , Refereed
  • Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells., Nozaki S, Takeda T, Kitaura T, Takenaka N, Kataoka T, Satoh T, Cellular signalling, 25(6), 1361 - 1371, Jun. 2013 , Refereed
  • MarR-type transcriptional regulator ChlR activates expression of tetrapyrrole biosynthesis genes in response to low-oxygen conditions in cyanobacteria., Aoki R, Takeda T, Omata T, Ihara K, Fujita Y, The Journal of biological chemistry, 287, 13500 - 13507, Apr. 2012 , Refereed
  • Validation of diffusive mini-samplers for aldehyde and VOC and its feasibility for measuring the exposure levels of elementary school children., Araki A, Tsuboi T, Kawai T, Bamai YA, Takeda T, Yoshioka E, Kishi R, Journal of environmental monitoring : JEM, 14, 368 - 374, Feb. 2012 , Refereed
  • Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma., Ueda S, Kitazawa S, Ishida K, Nishikawa Y, Matsui M, Matsumoto H, Aoki T, Nozaki S, Takeda T, Tamori Y, Aiba A, Kahn CR, Kataoka T, Satoh T, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(7), 2254 - 2261, Jul. 2010 , Refereed