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Okada Hitoshi


FacultyDepartment of Medicine / Graduate School of Medical Sciences
PositionSenior Administrator
Commentator Guide
Last Updated :2018/07/22

Education and Career


  •   1981 04  - 1987 03 , Tohoku University , School of Medicine
  •   1991 04  - 1995 03 , Tohoku University

Academic & Professional Experience

  •   2014 04 ,  - 現在, Professor, Kinki University, Faculty of Medicine
  •   2013 07 ,  - 2014 03 , Associate Professor, University of Toronto
  •   2005 05 ,  - 2014 03 , Staff Scientist, Campbell Family Institute for Breast Cancer Research
  •   2005 11 ,  - 2013 06 , Assistant Professor, University of Toronto
  •   2005 05 ,  - 2014 03 , Scientist, Ontario Cancer Institute
  •   1999 03 ,  - 2005 04 , Ontario Cancer Institute

Research Activities

Research Areas

  • Oncology, Tumor biology
  • Basic medicine, General medical chemistry
  • Basic medicine, Pathological medical chemistry
  • Laboratory animal science, Laboratory animal science

Research Interests

  • Tumor biology, Epgenome, Metabolism, Aging, DNA damage response, Apoptosis

Published Papers

  • Identification of a novel fusion gene HMGA2-EGFR in glioblastoma., Komuro A, Raja E, Iwata C, Soda M, Isogaya K, Yuki K, Ino Y, Morikawa M, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D, International journal of cancer, Nov. 2017 , Refereed
  • The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner., Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H, PloS one, 12(3), e0173713, 2017 , Refereed
  • Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model., Tong KI, Ota K, Komuro A, Ueda T, Ito A, Anne Koch C, Okada H, Cell death & disease, 7(10), Oct. 2016 , Refereed
  • Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse., Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, Yamashita T, Translational psychiatry, 6, e766, Mar. 2016 , Refereed
  • Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis., Martini E, Wittkopf N, Günther C, Leppkes M, Okada H, Watson AJ, Podstawa E, Backert I, Amann K, Neurath MF, Becker C, Cell reports, 14(5), 1062 - 1073, Feb. 2016 , Refereed
  • The role of histone demethylase KDM4B in Myc signaling in neuroblastoma., Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM, Journal of the National Cancer Institute, 107(6), Jun. 2015 , Refereed
  • Histone Lysine Demethylase and Human Diseases, Hitoshi Okada, ACTA MEDICA KINKI UNIVERSITY, 39(1), 1 - 10, Jun. 2014
  • Survivin Deletion Drives Mitotic Catastrophe in Intestinal Epithelial Cells, Martini E, Wittkopf N, Günther C, Okada H, Markus F Neurath, Becker C, Gastroenterology, 146(5), 86 - 87, Jan. 2014 , Refereed
  • Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion., Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK, Nature medicine, 18(9), 1394 - 1400, Sep. 2012 , Refereed
  • Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment., Wang F, Marshall CB, Yamamoto K, Li GY, Gasmi-Seabrook GM, Okada H, Mak TW, Ikura M, Proceedings of the National Academy of Sciences of the United States of America, 109(16), 6078 - 6083, Apr. 2012 , Refereed
  • Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model., Wu X, Zhang Q, Wang X, Zhu J, Xu K, Okada H, Wang R, Woo M, PloS one, 7(8), 2012 , Refereed
  • HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling., Goto K, Tong KI, Ikura J, Okada H, Cell death & disease, 2(12), Dec. 2011 , Refereed
  • Gestational glucose intolerance resulting from impaired beta cell mass expansion in the absence of survivin in female mice, X Wu, X Wang, J Zhu, Q Zhang, K Xu, T Yang, H Okada, M Woo, DIABETOLOGIA, 54, 25, Sep. 2011
  • Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development., Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H, PloS one, 6(3), Mar. 2011 , Refereed
  • Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice., Ma W, Ortiz-Quintero B, Rangel R, McKeller MR, Herrera-Rodriguez S, Castillo EF, Schluns KS, Hall M, Zhang H, Suh WK, Okada H, Mak TW, Zhou Y, Blackburn MR, Martinez-Valdez H, Cell research, 21(11), 1564 - 1577, Nov. 2011 , Refereed
  • Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis., Qiu W, Wang X, Leibowitz B, Liu H, Barker N, Okada H, Oue N, Yasui W, Clevers H, Schoen RE, Yu J, Zhang L, Proceedings of the National Academy of Sciences of the United States of America, 107(46), 20027 - 20032, Nov. 2010 , Refereed
  • Beta cell proliferation is impaired in the absence of survivin in the pancreas of duct-ligated adult mouse, X Wu, Q Zhang, C Liu, K Xu, X Mao, T Yang, H Okada, M Woo, DIABETOLOGIA, 53, 74 - 74, Sep. 2010
  • Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice., Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M, Diabetologia, 52(10), 2130 - 2141, Oct. 2009 , Refereed
  • Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis., Sasaki T, Marcon E, McQuire T, Arai Y, Moens PB, Okada H, The Journal of cell biology, 182(3), 449 - 458, Aug. 2008 , Refereed
  • The Potentially Role of Survivin in Pancreatic Islet Development and Function, Wu X, Wang L, Chen P, Okada H, Woo M, Canadian Journal of Diabetes, 32(4), 339, 2008 , Refereed
  • XIAP activity dictates Apaf-1 dependency for caspase 9 activation., Ho AT, Li QH, Okada H, Mak TW, Zacksenhaus E, Molecular and cellular biology, 27(16), 5673 - 5685, Aug. 2007 , Refereed
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53., Sasaki T, Gan EC, Wakeham A, Kornbluth S, Mak TW, Okada H, Genes & development, 21(7), 848 - 861, Apr. 2007 , Refereed
  • Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure, Perez GI, Acton BM, Jurisicova A, Perkins GA, White A, Brown J, Trbovich AM, Kim MR, Fissore R, Xu J, Ahmady A, D'Estaing SG, Li H, Kagawa W, Kurumizaka H, Yokoyama S, Okada H, Mak TW, Ellisman MH, Casper RF, Tilly JL., Cell Death Differ. , 14(3), 524 - 533, Mar. 2007 , Refereed
  • Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo., Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M, The EMBO journal, 26(1), 184 - 196, Jan. 2007 , Refereed
  • Generation and characterization of B7-H4/B7S1/B7x-deficient mice., Suh WK, Wang S, Duncan GS, Miyazaki Y, Cates E, Walker T, Gajewska BU, Deenick E, Dawicki W, Okada H, Wakeham A, Itie A, Watts TH, Ohashi PS, Jordana M, Yoshida H, Mak TW, Molecular and cellular biology, 26(17), 6403 - 6411, Sep. 2006 , Refereed
  • Smac/DIABLO and inhibitors of apoptosis (IAPs) constitute an alternative axis of caspase 9 activation independent of Apaf1-associated apoptosome, Ho AT, Li H, Okada H, Mak TW, Zacksenhaus E, Cancer Research, 66(8), 562 - 562, Apr. 2006
  • Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle., Alonso L, Okada H, Pasolli HA, Wakeham A, You-Ten AI, Mak TW, Fuchs E, The Journal of cell biology, 170(4), 559 - 570, Aug. 2005 , Refereed
  • Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner., Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW, Cancer research, 65(15), 6685 - 6691, Aug. 2005 , Refereed
  • Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis., Hao Z, Duncan GS, Chang CC, Elia A, Fang M, Wakeham A, Okada H, Calzascia T, Jang Y, You-Ten A, Yeh WC, Ohashi P, Wang X, Mak TW, Cell, 121(4), 579 - 591, May 2005 , Refereed
  • Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice., Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brandner S, Schulz JB, Mak T, Downward J, Molecular and cellular biology, 24(22), 9848 - 9862, Nov. 2004 , Refereed
  • SMAC deletion protects against ischemia-reperfusion-induced apoptosis, Gaussin V, Okada H, Foo RS, Kitsis RN, Circulation , 110(17), 42, Oct. 2004 , Refereed
  • p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1., You H, Jang Y, You-Ten AI, Okada H, Liepa J, Wakeham A, Zaugg K, Mak TW, Proceedings of the National Academy of Sciences of the United States of America, 101(39), 14057 - 14062, Sep. 2004 , Refereed
  • Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death., Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW, The Journal of experimental medicine, 199(3), 399 - 410, Feb. 2004 , Refereed
  • The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28., Suh WK, Tafuri A, Berg-Brown NN, Shahinian A, Plyte S, Duncan GS, Okada H, Wakeham A, Odermatt B, Ohashi PS, Mak TW, Journal of immunology (Baltimore, Md. : 1950), 172(10), 5917 - 5923, May 2004 , Refereed
  • Pathways of apoptotic and non-apoptotic death in tumour cells., Okada H, Mak TW., Nat Rev Cancer, 4(8), 592 - 603, 2004 , Refereed
  • The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses., Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW, Nature immunology, 4(9), 899 - 906, Sep. 2003 , Refereed
  • Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner., Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW, Molecular and cellular biology, 22(18), 6521 - 6532, Sep. 2002 , Refereed
  • Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice., Hamamoto T, Beppu H, Okada H, Kawabata M, Kitamura T, Miyazono K, Kato M, Cancer research, 62(20), 5955 - 5961, Oct. 2002 , Refereed
  • Generation and characterization of Smac/DIABLO-deficient mice., Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW, Molecular and cellular biology, 22(10), 3509 - 3517, May 2002 , Refereed
  • Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene., Hasegawa S, Sato T, Akazawa H, Okada H, Maeno A, Ito M, Sugitani Y, Shibata H, Miyazaki Ji J, Katsuki M, Yamauchi Y, Yamamura Ki K, Katamine S, Noda T, Proceedings of the National Academy of Sciences of the United States of America, 99(1), 297 - 302, Jan. 2002 , Refereed
  • Akt is activated in response to an apoptotic signal., Tang D, Okada H, Ruland J, Liu L, Stambolic V, Mak TW, Ingram AJ, The Journal of biological chemistry, 276(32), 30461 - 30466, Aug. 2001 , Refereed
  • Differential sensitivity of Kv1.4, Kv1.2, and their tandem channel to acidic pH: involvement of a histidine residue in high sensitivity to acidic pH., Ishii K, Nunoki K, Yamagishi T, Okada H, Taira N, The Journal of pharmacology and experimental therapeutics, 296(2), 405 - 411, Feb. 2001 , Refereed
  • Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells., Yokomizo T, Ogawa M, Osato M, Kanno T, Yoshida H, Fujimoto T, Fraser S, Nishikawa S, Okada H, Satake M, Noda T, Nishikawa S, Ito Y, Genes to cells : devoted to molecular & cellular mechanisms, 6(1), 13 - 23, Jan. 2001 , Refereed
  • Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells., Hayashi K, Natsume W, Watanabe T, Abe N, Iwai N, Okada H, Ito Y, Asano M, Iwakura Y, Habu S, Takahama Y, Satake M, Journal of immunology (Baltimore, Md. : 1950), 165(12), 6816 - 6824, Dec. 2000 , Refereed
  • The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region., Mukouyama Y, Chiba N, Hara T, Okada H, Ito Y, Kanamaru R, Miyajima A, Satake M, Watanabe T, Developmental biology, 220(1), 27 - 36, Apr. 2000 , Refereed
  • CELLULAR IMMUNOLOGY AND IMMUNE REGULATION-Diminution of the AML1 Transcription Factor Function Causes Differential Effects on the Fates of CD4 and CD8 Single-Positive T Cells, Keitaro Hayashi, Waka Natsume, Toshio Watanabe, Natsumi Abe, Naomi Iwai, Hitoshi Okada, Yoshiaki Ito, Masahide Asano, Yoichiro Iwakura, Sonoko Habu, Yousuke Takahama, Masanobu Satake, Journal of Immunology, 165(12), 6816 - 6824, 2000 , Refereed
  • AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene., Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M, Oncogene, 17(18), 2287 - 2293, Nov. 1998 , Refereed
  • Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor., Niki M, Okada H, Takano H, Kuno J, Tani K, Hibino H, Asano S, Ito Y, Satake M, Noda T, Proceedings of the National Academy of Sciences of the United States of America, 94(11), 5697 - 5702, May 1997 , Refereed
  • Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene., Sakaguchi S, Katamine S, Nishida N, Moriuchi R, Shigematsu K, Sugimoto T, Nakatani A, Kataoka Y, Houtani T, Shirabe S, Okada H, Hasegawa S, Miyamoto T, Noda T, Nature, 380(6574), 528 - 531, Apr. 1996 , Refereed
  • Cloning of a swelling-induced chloride current related protein from rabbit heart., Okada H, Ishii K, Nunoki K, Taira N, Biochimica et biophysica acta, 1234(1), 145 - 148, Mar. 1995 , Refereed
  • Hybrid potassium channels by tandem linkage of inactivating and non-inactivating subunits., Nunoki K, Ishii K, Okada H, Yamagishi T, Murakoshi H, Taira N, The Journal of biological chemistry, 269(39), 24138 - 24142, Sep. 1994 , Refereed
  • Modulation of transient type K channel cloned from rat heart., Okada H, Ishii K, Nunoki K, Abe T, Taira N, Biochemical and biophysical research communications, 189(1), 430 - 436, Nov. 1992 , Refereed

Conference Activities & Talks

  • Role of histone demethylases in breast cancer development, Hitoshi Okada, The 76th Annual Meeting of the Japanese Cancer Association,   2017 09 29
  • Attenuated DNA damage repair delays therapy-related malignancies in mouse model, Hitoshi Okada, The 75th Annual Meeting of the Japanese Cancer Association,   2016 10 06
  • H3K9 histone demethylase, KDM4B, regulates mammary gland development, Hitoshi Okada,   2015 12 01
  • Attenuated DNA damage repair delays therapy-related malignancies in mouse model, Hitoshi Okada, The 12th International Conference on Protein Phosphatase International Symposium,   2016 10 29


  • ヒストン脱メチル化酵素による白血病発症機構と分子治療標的の可能性, 上田健, 古室暁義, 太田一成, 岡田斉, 近畿大学医学雑誌, 41, 3-4, 17A,   2016 12 20 ,
  • 膠芽腫における新規融合遺伝子HMGA2‐EGFRの同定, 古室暁義, 太田一成, 上田健, 岡田斉, 近畿大学医学雑誌, 41, 3-4, 20A,   2016 12 20 ,
  • ヒストン脱メチル化酵素UTXによる脂肪細胞制御メカニズムの解明, 太田一成, 古室暁義, 上田健, 岡田斉, 近畿大学医学雑誌, 41, 3-4, 17A,   2016 12 20 ,
  • ヒストン脱メチル化酵素UTXによる脂肪細胞分化メカニズムの解明, 太田一成, TONG Kit I., 後藤幸一郎, 古室暁義, 岡田斉, 日本分子生物学会年会プログラム・要旨集(Web), 39th, ROMBUNNO.3P‐0785 (WEB ONLY),   2016 ,
  • トリプルネガティブ乳がん治療耐性獲得機序に関する知的基盤の確立, 岡田斉, 古室顕義, 金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的研究拠点, 2015, 80,   2016 ,
  • 骨形成因子4(BMP4)はGlioma Initiating cellのがん幹細胞性を阻害して治療効果を促進する., 古室暁義, 太田一成, 岡田斉, 近畿大学医学雑誌, 40, 3-4, 17A,   2015 12 21 ,
  • ヒストン脱メチル化酵素UTXによる脂肪細胞分化メカニズムの解明, 太田一成, 古室暁義, 岡田斉, 近畿大学医学雑誌, 40, 3-4, 18A,   2015 12 21 ,
  • 環境応答信号伝達経路とがん, 岡田斉, 近畿大学医学雑誌, 40, 3-4, 9A,   2015 12 21 ,
  • ヒストン脱メチル化酵素UTXによる脂肪細胞分化メカニズムの解明, 太田一成, TONG Kit I., 後藤幸一郎, 古室暁義, 岡田斉, 日本生化学会大会(Web), 88th, 3P1220 (WEB ONLY),   2015 ,
  • ヒストン脱メチル化酵素による乳腺発達の制御, 岡田斉, 佐相薫葉子, 河津正人, 古室暁義, 太田一成, 日本生化学会大会(Web), 88th, 1T17P-01(1P0955) (WEB ONLY),   2015 ,
  • ヒストン脱メチル化酵素KDM4B(JMJD2B)欠損による肥満誘導, 岡田斉, 日本生化学会大会(Web), 87th, 3T15P-14(2P-363) (WEB ONLY),   2014 ,
  • マウス成体型造血の不均一性, 横溝智雅, 望月奈穂美, 黒羽高志, 依馬正次, 大里元美, 岡田斉, 小川峰太郎, 西川伸一, 伊藤嘉明, 日本分子生物学会年会プログラム・講演要旨集, 26th, 626,   2003 11 25 ,
  • RUNX1(AML1/PEBP2αB)は血管内皮細胞からの血液細胞の産生に必須の因子である, 横溝智雅, 小川峰太郎, 大里元美, 吉田尚弘, FRASER S, 岡田斉, 佐竹正延, 野田哲生, 伊藤嘉明, Int J Hematol Suppl, 71, 1, 183,   2000 04 ,
  • PEBP2αB/AML1は血管内皮細胞からの血球の産生に必須の因子である, 横溝智雅, 小川峰太郎, 大里元美, 吉田尚弘, 藤本哲広, FRASER S, 岡田斉, 佐竹正延, 野田哲生, 日本分子生物学会年会プログラム・講演要旨集, 22nd, 694,   1999 11 22 ,
  • PEBP2αB/AML1(+/-)マウスの血液学的解析, 大里元美, 小川峰太郎, 横溝智雅, 藤本哲広, 岡田斉, 佐竹正延, 野田哲生, 西川伸一, 伊藤嘉明, 日本分子生物学会年会プログラム・講演要旨集, 22nd, 491,   1999 11 22 ,
  • PEBP2aB/AML1(+/-)マウスの血液学的解析, 大里元美, 小川峰太郎, 横溝智雅, 藤本哲広, STUART F, 岡田斉, 佐竹正延, 野田哲生, 伊藤嘉明, 日本癌学会総会記事, 58th, 218,   1999 08 30 ,
  • PEBP2αB/AML1は血管内皮細胞からの成体型血球の産生に必須の因子である, 横溝智雅, 小川峰太郎, 大里元美, 吉田尚弘, 岡田斉, 野田哲生, 菅野智彦, 西川伸一, 伊藤嘉明, 日本癌学会総会記事, 58th, 156,   1999 08 30 ,
  • The role of mgl gene family during development of mouse., 高野洋志, 寺社下浩一, 中井茂康, 久野淳子, 小林智子, 岡田斉, 美野輪治, 野田哲生, 日本分子生物学会年会プログラム・講演要旨集, 20th, 523,   1997 12 ,
  • The critical role of AML1, the most frequent target of the leukemia-associated translocations, for embryonic hematopoiesis., 岡田斉, 仁木賢, 高野洋志, 日比野仁, 谷憲三郎, 浅野茂隆, 渡辺利雄, 伊藤嘉明, 野田哲生, 日本分子生物学会年会プログラム・講演要旨集, 20th, 669,   1997 12 ,
  • Targeting the genes encoding a PEBP2/CBF transcription factor., 仁木賢, 岡田斉, 野田哲生, 佐竹正延, 月刊血液・腫よう科, 34, 4, 298, 302,   1997 04 ,
  • Gene targeting file -'97. Generation and differentiation. Generation and differentiation file. Gene Pax5 controling morphogenesis of the mesencephalon and differentiation of B-lymphocytes., 岡田斉, 野田哲生, 実験医学, 14, 20, 2804, 2806,   1996 12 ,
  • Gene targeting file -'97. Nervous system. Nervous system file. Generation. Essential transcription factor BF-1 for the development of the cerebral hemisphaere., 岡田斉, 野田哲生, 実験医学, 14, 20, 2738, 2741,   1996 12 ,
  • Gene targeting file -'97. Practice of gene targeting., 岡田斉, 野田哲生, 実験医学, 14, 20, 2710, 2714,   1996 12 ,
  • Gene targeting file -'97. Immune system. Immune system file. Gene controling differentiation of all lymphocytic cells, 岡田斉, 野田哲生, 実験医学, 14, 20, 2860, 2861,   1996 12 ,
  • ジーンターゲティング法によるPEBP2β遺伝子機能の解析, 仁木賢, 岡田斉, 高野洋志, 久野淳子, 伊藤嘉明, 佐竹正延, 野田哲生, 日本分子生物学会年会プログラム・講演要旨集, 19th, 792,   1996 07 ,
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  • Mechanisms of modulation of cloned cardiac K channels., 石井邦明, 岡田斉, 布木和夫, 平則夫, 心臓, 25, 2, 223, 227,   1993 02 ,

Research Grants & Projects

  • Canadian Institute of Health Research, Operating grant, To investigate role of Bat3 in nuclear oncogenic signaling networks, Hitoshi Okada
  • Japan Sciety for the Promotion of Science, Grant in Aid for Scientific Research, Histone demethylase regulates mammary gland development and breast cancer development, Hitoshi Okada
  • Canadian Institute of Health Research, Epigenetics, Environment and Health (CEEHR) Catalyst Grant, Establishment of in vivo and in vitro models for systematic tissue-specific epigenomic mapping, Hitoshi Okada
  • Canadian Institute of Health Research, Operating grant, To investigate the roles of histone demethylases in estrogen receptor signaling Network, Hitoshi Okada
  • Canadian Breast Cancer Foundation, Operating grant, Roles of heat-shock 70 family of proteins in breast cancer, Hitoshi Okada
  • Canadian Institute of Health Research, Operating grant, Role of post-translational modifications of p53 in cancer pathogenesis, Hitoshi Okada
  • University Health Network, Operating grant, Role of apoptosis signaling pathway in tumorigenesis, Hitoshi Okada


Social Contribution

  • Weekend to End Women's Cancers Walks, Advisor, Campbell Family Institue for Breast Cancer Research, Ontario Cancer Institute,   2005 09  - 2013 09