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YUASA Haruyuki

    Department of Medicine　Associate Professor
Last Updated :2024/04/25

Researcher Information

J-Global ID

Research Areas

  • Life sciences / Anesthesiology

Association Memberships

  • THE JAPAN SOCIETY FOR MEDICAL EDUCATION   THE JAPANESE ASSOCIATION FOR MEDICAL SIMULATION   THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA   JAPANESE SOCIETY OF ANESTHESIOLOGISTS   

Published Papers

  • Hiroatsu Sakamoto; Atsuhiro Kitaura; Shota Tsukimoto; Yukari Yoshino; Takashi Mino; Haruyuki Yuasa; Yasufumi Nakajima
    JA clinical reports 10 (1) 13 - 13 2024/02
  • Atsuhiro Kitaura; Hiroatsu Sakamoto; Kensuke Toho; Shota Tsukimoto; Haruyuki Yuasa; Yasufumi Nakajima
    JA clinical reports 9 (1) 83 - 83 2023/12
  • Atsuhiro Kitaura; Issei Fukuda; Haruyuki Yuasa; Shota Tsukimoto; Yasufumi Nakajima
    JA Clinical Reports Springer Science and Business Media LLC 9 (1) 2023/11
  • Haruyuki Yuasa; Atsuhiro Kitaura; Yasuyo Miura; Shota Tsukimoto; Yasufumi Nakajima; Shinichi Nakao
    Acta Med Kindai Univ 48 (1) 21 - 26 2023/03 [Refereed]
  • Atsuhiro Kitaura; Shinichi Nakao; Haruyuki Yuasa; Shota Tsukimoto; Yasuhumi Nakajima
    The American journal of case reports 23 e938609  2022/12 
    BACKGROUND Prevention of lethal arrhythmias in congenital long QT syndrome type 1 (LQT1) requires avoidance of sympathoexcitation, drugs that prolong QT, and electrolyte abnormalities. However, it is often difficult to avoid all these risks in the perioperative period of open heart surgery. Herein, we report hypokalemia-induced cardiac arrest in a postoperative cardiac patient with LQT1 on catecholamine. CASE REPORT A 79-year-old woman underwent surgical aortic valve replacement for severe aortic stenosis. Although the initial plan was not to use catecholamine, catecholamine was used in the Postoperative Intensive Care Unit with attention to QT interval and electrolytes due to heart failure caused by postoperative bleeding. Serum potassium levels were controlled above 4.5 mEq/L, and no arrhythmic events occurred. On postoperative day 4, the patient was started on insulin owing to hyperglycemia. Cardiac arrest occurred after the first insulin dose; the implantable cardioverter defibrillator was activated, and the patient's own heartbeat resumed. Subsequent examination revealed that a marked decrease in serum potassium level had occurred after insulin administration. The electrocardiogram showed obvious QT prolongation and ventricular fibrillation following R on T. Thereafter, under strict potassium management, there was no recurrence of cardiac arrest events. CONCLUSIONS A patient with LQT1 who underwent open heart surgery developed ventricular fibrillation after Torsades de Pointes, probably due to hypokalemia after insulin administration in addition to catecholamine. It is important to check serum potassium levels to avoid the onset of Torsades de Pointes in patients with long QT syndrome. In addition, the impact of insulin administration was reaffirmed.
  • Haruyuki Yuasa; Atsuhiro Kitaura; Chiyako Kitayama; Masaki Fuyuta; Takashi Mino; Ken Okamoto; Shinichi Nakao
    The American journal of case reports 22 e927756  2021/03 
    BACKGROUND Brugada syndrome is a potentially fatal cardiac arrhythmia characterized by incomplete right bundle-branch block (RBB) and characteristic ST-segment elevation in the anterior electrocardiogram (ECG) leads. This report is of a case of type 2 Brugada syndrome, and discusses the importance of preoperative history and ECG evaluation. CASE REPORT A 32-year-old man was scheduled for tympanoplasty. His preoperative ECG revealed saddleback-type J waves in V₂ (>2 mm) and ST increase (>1 mm) detected 1 week before elective surgery, but the ECG 1 year before showed normal. He had no notable past history. Anesthesia was induced with remifentanil and propofol, and maintained with sevoflurane in combination with remifentanil. Routine monitoring of vital signs was supplemented with V2 monitoring on the ECG. The heart rate was maintained at above 60 beats/min using ephedrine. The course of the operation was uneventful. CONCLUSIONS We managed anesthesia for a patient with a type 2 Brugada syndrome ECG without events, probably because he had no notable past history such as syncope. Type 2 and type 3 Brugada syndrome ECGs are difficult to recognize, and patients with them are considered to be less risky than a patient with a type I ECG. However, as Brugada syndrome ECG is dynamic and changeable, a type 2 or 3 Brugada syndrome ECG can change to a type I ECG under some conditions, and thus should not be overlooked, and the patient's past history or symptoms, such as syncope, should be carefully investigated.
  • Haruyuki Yuasa; Yukio Onoda; Atsuhiro Kitaura; Takashi Mino; Shota Tsukimoto; Shinichi Nakao
    JA Clinical Reports Springer Science and Business Media LLC 6 (1) 72 - 72 2020/12 [Refereed]
     
    Abstract Background In a patient with very long-chain acyl-Coenzyme A dehydrogenase (VLCAD) deficiency, metabolism of fatty acids is impaired and a supply of alternative energy is limited when glucose level is insufficient on starvation. Case presentation A 37-year-old woman with VLCAD deficiency was diagnosed with an ovarian cyst and was scheduled for laparoscopic ovarian cystectomy. Glucose was administered intravenously with the start of fasting. Anesthesia was induced with remifentanil, midazolam, and thiamylal, maintained with desflurane and remifentanil. Body temperature was maintained at 36.2–36.7 °C. During anesthesia, hypoglycemia did not occur, creatine kinase levels were in the normal range, and myoglobinuria was not detected. No shivering was observed after extubation. Conclusions Glucose was administered to avoid perioperative hypoglycemia. Body temperature was controlled to avoid shivering, which would otherwise increase skeletal muscle energy needs. Blood creatine kinase did not increase, and myoglobinuria was not detected; thus, rhabdomyolysis was unlikely to develop.
  • 坂本 悠篤; 辻本 宜敏; 高岡 敦; 白井 達; 湯浅 晴之; 中尾 慎一
    日本臨床麻酔学会誌 日本臨床麻酔学会 40 (6) S341 - S341 0285-4945 2020/10
  • 月本 翔太; 湯浅 晴之; 上原 圭司; 梅村 沙紀; 古藤 大和; 湯浅 あかね; 中尾 慎一
    日本臨床麻酔学会誌 日本臨床麻酔学会 40 (6) S289 - S289 0285-4945 2020/10
  • 吉野 由佳梨; 法里 慧; 松島 麻由佳; 北浦 淳寛; 湯浅 晴之; 中尾 慎一
    日本臨床麻酔学会誌 日本臨床麻酔学会 40 (6) S327 - S327 0285-4945 2020/10
  • ロクロニウムによるアナフィラキシーの一例
    吉野 由佳梨; 法里 慧; 松島 麻由佳; 北浦 淳寛; 湯浅 晴之; 中尾 慎一
    日本臨床麻酔学会誌 日本臨床麻酔学会 40 (6) S327 - S327 0285-4945 2020/10
  • Takashi Mino; Seishi Kimura; Atsuhiro Kitaura; Tatsushige Iwamoto; Haruyuki Yuasa; Yasutaka Chiba; Shinichi Nakao
    PloS one 15 (11) e0241591  2020 
    BACKGROUND: Severe aortic stenosis (AS) is increasing in the aging society and is a serious condition for anesthetic management. However, approximately one-third of patients with severe AS are asymptomatic. Echocardiography is the most reliable method to detect AS, but it takes time and is costly. METHODS: Data were obtained retrospectively from patients who underwent surgery and preoperative transthoracic echocardiography (TTE). LVH on ECG was determined by voltage criteria (Sv1 + Rv5 or 6 ≥3.5 mV) and/or the strain pattern in V5 and V6. Severe AS was defined as a mean transaortic pressure gradient ≥40 mmHg or aortic valve area ≤1.0 cm2 by TTE. RESULTS: Data for 470 patients aged 28-94 years old were obtained. One hundred and twenty-six patients had severe AS. LVH on ECG by voltage criteria alone was detected in 182 patients, LVH by strain pattern alone was detected in 80 patients and LVH by both was detected in 55 patients. Multivariable logistic analysis revealed that LVH by the strain pattern or voltage criteria, diabetes mellitus, and age were significantly associated with severe AS. The AUC for the ROC curve for LVH by voltage criteria alone was 0.675 and the cut-off value was 3.84 mm V, and the AUC for the ROC for age was 0.675 and the cut-off value was 74 years old. CONCLUSION: Our study suggests that patients who are 74 years old or over with LVH on ECG, especially those with DM, should undergo preoperative TTE in order to detect severe AS.
  • 尿道カテーテル挿入の必要性に関して
    Yuasa haruyuki; Nakao Shinichi
    Clinical 43 424 - 425 2019 [Refereed]
  • Haruyuki Yuasa; Hiroyuki Yokoyama; Naohiro Yonemoto; Yoichiro Kasahara; Hiroshi Nonogi
    ISRN Anesthesiology 2012 2012 [Refereed]
  • 泌尿器科手術で用いる麻酔の基本
    中尾 慎一; 冬田 昌樹; 湯浅 晴之; 梶川 竜治; 塩川 泰啓; 篠村 徹太郎
    泌尿器ケア 16 17 - 57 2011/12 [Invited]
  • Chika Nishiyama; Taku Iwami; Takashi Kawamura; Masahiko Ando; Kentaro Kajino; Naohiro Yonemoto; Risa Fukuda; Haruyuki Yuasa; Hiroyuki Yokoyama; Hiroshi Nonogi
    RESUSCITATION ELSEVIER IRELAND LTD 80 (10) 1164 - 1168 0300-9572 2009/10 [Refereed]
     
    Objectives: To evaluate the effectiveness of 1-h practical chest compress inn-only cardiopulmonary resuscitation (CPR) training with or without a preparatory self-learning video.Methods: Participants were randomly assigned to either a control group or a video group who received a self-learning video before attending the 1-h chest compression-only CPR training program. The primary outcome measure was the total number of chest compressions during a 2-min test period.Results: 214 participants were enrolled, 183 of whom completed this study. In a simulation test just before practical training began, 88 (92.6%) of the video group attempted chest compressions, while only 58 (64.4%) of the control group (p < 0.001) did so. The total number of chest compressions was significantly greater in the video group than in the control group (100.5 +/- 61.5 versus 74.4 +/- 55.5, p = 0.012). The proportion of those who attempted to use an automated external defibrillator (AED) was significantly greater in the video group (74.7% versus 28.7%, p < 0.001). After the 1-h practical training, the number of total chest compressions markedly increased regardless of the type of CPR training program and intergroup differences had almost disappeared (161.0 +/- 31.8 in the video group and 159.0 +/- 35.7 in the control group, p = 0.628).Conclusions: 1-h chest compression-only CPR training makes it possible for the general public to perform satisfactory chest compressions. Although a self-learning video encouraged people to perform CPR, their performance levels were not sufficient, confirming that practical training as well is essential. (UMIN000001046). (C) 2009 Elsevier Ireland Ltd. All rights reserved.
  • Chika Nishiyama; Taku Iwami; Takashi Kawamura; Masahiko Ando; Robert A. Berg; Naohiro Yonemoto; Risa Fukuda; Haruyuki Yuasa; Akiko Kada; Hiroyuki Yokoyama; Hiroshi Nonogi
    CIRCULATION LIPPINCOTT WILLIAMS & WILKINS 116 (16) 581 - 581 0009-7322 2007/10 [Refereed]
  • Chika Nishiyama; Taku Iwami; Takashi Kawamura; Masahiko Ando; Robert A. Berg; Naohiro Yonemoto; Risa Fukuda; Haruyuki Yuasa; Akiko Kada; Hiroyuki Yokoyama; Hiroshi Nonogi
    CIRCULATION LIPPINCOTT WILLIAMS & WILKINS 116 (16) 937 - 937 0009-7322 2007/10 [Refereed]
  • Haruyuki Yuasa; Hiroyuki Yokoyama; Naohiro Yonemoto; Akiko Kada; Yoichiro Kasahara; Yoshihisa Koga; Hiroshi Nonogi
    CIRCULATION LIPPINCOTT WILLIAMS & WILKINS 116 (16) 944 - 944 0009-7322 2007/10 [Refereed]
  • 「胸骨圧迫のみに単純化した心肺蘇生法」解説ビデオ教材の効果の検討
    西山 知佳; 石見 拓; 川村 孝; 安藤 昌彦; 嘉田 晃子; 福田 理砂; 横山 広行; 湯浅 晴之; 野々木 宏
    日本救急医学会雑誌 (一社)日本救急医学会 18 (8) 396 - 396 0915-924X 2007/08
  • H Yuasa; T Higashizawa; Y Koga
    ANESTHESIA AND ANALGESIA LIPPINCOTT WILLIAMS & WILKINS 92 (6) 1618 - 1618 0003-2999 2001/06 [Refereed]
  • H. Morita; T. Higashizawa; H. Yuasa; K. Hiramatsu; Y. Koga
    Japanese Journal of Anesthesiology 47 (11) 1311 - 1314 0021-4892 1998 [Refereed]
     
    Mexiletine, an antiarrhythmic agent, was preincisionally administered intravenously for the purpose of reducing postoperative pain. Twenty-eight female patients for mastectomy were studied. The patients were divided into three groups. Group 1 received no mexiletine. Group 2 received bolus administration of mexiletine 1 mg · kg-1 with additional continuous administration of 1 mg · kg-1 · hr-1 for 75 minutes. Group 3 received bolus administration of mexiletine 2 mg · kg-1. The requirement of butorphanol as a postoperative analgesic within 1 hour after mastectomy in Group 3 was significantly lower than that in Group 1 (P< 0.05), but butorphanol requirement in Group 2 was not significantly lower than that in Group 1. Plasma mexiletine concentration was slightly higher in Group 3 (1.7 μg · ml-1) than that in Group 2 (1.0 μg · ml-1) immediately after the intravenous mexiletine administration, although there was no significant difference. The results indicate that mexiletine 2 mg · kg-1 as preoperative bolus administration maintains its plasma concentration above 1.7 μg · ml-1, and is clinically effective for reducing the postoperative pain after mastectomy.
  • T.Higashizawa; K.Hiramatsu; H.Yuasa; T.Izumi K.Kawata; Y. Koga
    Pain Reserch 13 (1) 9 - 13 0915-8588 1998 [Refereed]
  • H. Yuasa; K. Okada; S. Ueshima; O. Matsuo
    Pathophysiology 4 (3) 169 - 174 0928-4680 1997/09 [Refereed]
     
    Sodium ozagrel inhibits platelet aggregation through thromboxane (TX) synthetase inhibition. In vitro, the combination of antiplatelet agents with plasminogen activators (PAs) is more effective for thrombolytic therapy than are PAs alone. Therefore, the influence of sodium ozagrel on platelet rich plasma (PRP) clot lysis was investigated in this study. Firstly, PRP clot lysis was performed: PRP clots containing sodium ozagrel were lyzed by a urokinase-type PA. PRP clot lysis was significantly enhanced by sodium ozagrel in a dose-dependent manner: Secondly, clot solubility was investigated by a urea solubility test. The solubility of PRP clots was enhanced by sodium ozagrel in a dose-dependent manner. Moreover, the influence of sodium ozagrel on the density of PRP clots was studied. The density of the PRP clots was decreased by sodium ozagrel in a dose-dependent manner. PAI-1 antigen which was released from activated platelets was reduced by sodium ozagrel in a dose-dependent manner. These findings indicate that the enhancement of PRP clot lysis by sodium ozagrel is due to enhanced solubility, decreased density and reduced PAI-1 antigen release.
  • K Okada; S Ueshima; T Takaishi; H Yuasa; H Fukao; O Matsuo
    AMERICAN JOURNAL OF HEMATOLOGY WILEY-LISS 53 (3) 151 - 157 0361-8609 1996/11 [Refereed]
     
    Staphylokinase obtains plasminogen activating activity by forming a complex with plasminogen, Although the enzymatic activity of staphylokinase is enhanced by fibrin, how fibrin enhances enzymatic activity has not been determined yet. The effects of fibrin, or fibrinogen fragments, on the activation of plasminogen by staphylokinase was investigated using CNBr-digested fibrinogen fragments (FCB-2 and FCB-5) and plasmin-degraded cross-linked fibrin fragments ((DD)E complex, Do fragments and E fragments). Kinetic analysis of the activity of staphylokinase revealed that its plasminogen activating activity, which was expressed as kcat/Km, was enhanced by FCB-2 (10-fold) and FCB-5 (5-fold). These fibrin fragments caused 38-, 30-, and 8.5-fold increases in activity for the DD fragment, (DD)E complex and E fragment, respectively, Although alpha(2)-antiplasmin inhibited the activation of plasminogen by staphylokinase, FCB-5 abolished its inhibitory effects, and the plasminogen activating activity of staphylokinase was restored. The inhibitory effects of alpha(2)-antiplasmin on the activation of mini-plasminogen by staphylokinase were less than for Glu- or Lys-plasminogen, and the inhibitory effect of alpha-antiplasmin was not altered by fibrin or EACA. These findings indicate that the staphylokinase/plasmin(ogen) complex reacts with fibrin even in the presence of alpha(2)-antiplasmin, and efficient plasminogen activation takes place on the surface of fibrin. (C) 1996 Wiley-Liss, Inc.
  • Mechanism of platelet rich plasma clot lysis with anticoagulant and antiplatelet agents
    Haruyuki Yuasa
    Kindai University Faculty of Medicine 20 331 - 344 1996 [Refereed]
  • Kiyotaka Okada; Haruyuki Yuasa; Yasuhiro Hagiya; Tomoaki Takaishi; Hideharu Fukao; Shigeru Ueshima; Osamu Matsuo
    Clinical and Experimental Pharmacology and Physiology 22 S275 - S276 1440-1681 1995 [Refereed]
     
    1. Plasminogen activator activity was detected in the extract solution of the liver tissues of both stroke‐prone spontaneously hypertensive rats (SHRSP) and Wistar‐Kyoto (WKY) rats by the synthetic substrate assay. 2. The total PA activity in the liver extract of WKY (26.8 ± 8.3 i.u.) was about 1.5‐fold higher than that of SHRSP (18.5 ± 4.1 i.u., n = 8, P < 0.005). 3. The enzymography of the liver extract revealed three lytic bands with a molecular weight of 67 kDa, 44 kDa and 38 kDa. 4. The inhibitor activity of the liver extract was detected by the reverse fibrin autography method with one lytic resistance hand at 70 kDa. 5. Thus, fibrinolytic components exist in the liver tissue of both strains of rats, but their contribution to the stroke requires further study. Copyright © 1995, Wiley Blackwell. All rights reserved
  • K OKADA; H YUASA; Y HAGIYA; H FUKAO; S UESHIMA; O MATSUO
    THROMBOSIS RESEARCH PERGAMON-ELSEVIER SCIENCE LTD 76 (2) 181 - 191 0049-3848 1994/10 [Refereed]
     
    Staphylokinase (SAK) expresses plasminogen activator activity by forming a complex with plasminogen. In order to elucidate the mechanism for the expression of enzymatic activity of the complex, a cross-linked staphylokinase/plasminogen (SAK/plg) complex was produced with disuccinimidyl suberate, and its enzymatic characteristics were compared with those of a streptokinase/plasminogen (SK/plg) complex. SAK/plg complex and SK/plg complex showed a band with a molecular weight of 110 kDa and 140 kDa by SDS-PAGE under non-reduced condition, respectively. Both complexes exhibited plasminogen activator activity in a concentration-dependent manner on fibrin film and synthetic chromogenic substrate assay. The kinetic analysis of enzymatic activity of both complexes was performed. The plasminogen activator activity of SAK/plg complex was enhanced about 5-fold in the presence of FCB-2. However, SK/plg complex showed only 1.7-fold increase in the presence of FCB-2. These findings indicate that the SAK/plg complex reacts with fibrin, and efficient plasminogen activation is induced on fibrin surface.

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