ADACHI Toru

Researcher Information

J-Global ID

• 202201016813100503

Published Papers

• Right prefrontal function and coping strategies in patients with remitted major depressive disorder.

  Noa Tsujii; Wakako Mikawa; Toru Adachi; Soichiro Sakanaka; Osamu Shirakawa

  Progress in neuro-psychopharmacology & biological psychiatry 108 110085 - 110085 2021/06 

  BACKGROUND: Patients with remitted major depressive disorder (rMDD) generally rely on maladaptive coping strategies for stressful situations. These maladaptive copings are associated with an elevated relapse risk of rMDD; however, their neural basis remains poorly understood. METHODS: We enrolled (1) 45 patients with rMDD (17-item Hamilton Depression Rating Scale [HRSD17] total score ≤ 3) and (2) 56 healthy controls (HCs). Coping styles were measured using the Coping Inventory for Stressful Situations (CISS) according to three coping dimensions: avoidance-, emotion-, and task-oriented copings. The cognitive strategic processes of the prefrontal cortex were measured using a verbal fluency task (VFT). Furthermore, regional frontotemporal hemodynamic responses were monitored by near-infrared spectroscopy (NIRS). RESULTS: Patients with rMDD had significantly lower task-oriented coping scores and significantly higher avoidance- and emotion-oriented coping scores than HCs. Predominantly in the left frontotemporal region, patients with rMDD had lower frontotemporal hemodynamic responses during a VFT than HCs. Hemodynamic responses in the right inferior frontal gyrus of patients with rMDD were significantly and negatively associated with avoidance-oriented coping scores, but not of HCs. Conversely, those responses of HCs were significantly and positively associated with task-oriented coping scores, but not of patients with rMDD. DISCUSSION: Alteration in the right inferior frontal cortex plays an important role in dysfunction to stress response in patients with rMDD. Differential functioning patterns of the right inferior frontal cortex associated with coping strategies may link to MDD recurrence vulnerability.
• Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder.

  Noa Tsujii; Wakako Mikawa; Toru Adachi; Tomoyuki Hirose; Osamu Shirakawa

  Scientific reports 8 (1) 4686 - 4686 2018/03 

  Schizophrenia (SZ) and bipolar I disorder (BD-I) share genetic risk factors and cognitive impairments, but these conditions may exhibit differences in cortical functioning associated with inhibitory control. We measured hemodynamic responses during a stop-signal task using near-infrared spectroscopy (NIRS) in 20 patients with SZ, 21 patients with BD-I and 18 healthy controls (HCs). We used stop-signal reaction time (SSRT) to estimate behavioural inhibition. Compared with HCs, patients with either SZ or BD-I exhibited significantly reduced activation in the bilateral inferior, middle and superior frontal gyri. Furthermore, patients with BD-I showed inactivation of the right superior temporal gyri compared with patients with SZ or HCs. Patients with SZ or BD-I demonstrated significant negative correlations between SSRT and hemodynamic responses of the right inferior frontal gyrus. Moreover, patients with SZ exhibited correlations in the middle and superior frontal gyri. Our findings suggest that right inferior frontal abnormalities mediate behavioural inhibition impairments in individuals with SZ or BD-I. Differential patterns of orbitofrontal or superior temporal functional abnormalities may reflect important differences in psychopathological features between these disorders.
• Reduced left precentral regional responses in patients with major depressive disorder and history of suicide attempts.

  Noa Tsujii; Wakako Mikawa; Emi Tsujimoto; Toru Adachi; Atsushi Niwa; Hisae Ono; Osamu Shirakawa

  PloS one 12 (4) e0175249  2017 

  Previous neuroimaging studies have revealed frontal and temporal functional abnormalities in patients with major depressive disorder (MDD) and a history of suicidal behavior. However, it is unknown whether multi-channel near-infrared spectroscopy (NIRS) signal changes among individuals with MDD are associated with a history of suicide attempts and a diathesis for suicidal behavior (impulsivity, hopelessness, and aggression). Therefore, we aimed to explore frontotemporal hemodynamic responses in depressed patients with a history of suicide attempts using 52-channel NIRS. We recruited 30 patients with MDD and a history of suicidal behavior (suicide attempters; SAs), 38 patient controls without suicidal behavior (non-attempters; NAs), and 40 healthy controls (HCs) matched by age, gender ratio, and estimated IQ. Regional hemodynamic responses during a verbal fluency task (VFT) were monitored using NIRS. Our results showed that severities of depression, impulsivity, aggression, and hopelessness were similar between SAs and NAs. Both patient groups had significantly reduced activation compared with HCs in the bilateral frontotemporal regions. Post hoc analyses revealed that SAs exhibited a smaller hemodynamic response in the left precentral gyrus than NAs and HCs. Furthermore, the reduced response in the left inferior frontal gyrus was negatively correlated with impulsivity level and hemodynamic responses in the right middle frontal gyrus were negatively associated with hopelessness and aggression in SAs but not in NAs and HCs. Our findings suggest that MDD patients with a history of suicide attempts demonstrate patterns of VFT-induced NIRS signal changes different from those demonstrated by individuals without a history of suicidal behaviors, even in cases where clinical symptoms are similar. NIRS has a relatively high time resolution, which may help visually differentiate SAs from NAs.
• Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression.

  Noa Tsujii; Wakako Mikawa; Emi Tsujimoto; Hiroyuki Akashi; Toru Adachi; Eiji Kirime; Osamu Shirakawa

  Psychiatry research. Neuroimaging 253 26 - 35 2016/07 

  This study aimed to determine whether quality of life (QOL) reflects specific functional abnormalities of frontotemporal hemodynamic responses in melancholia. We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (MDD-NMF), and 68 healthy control subjects who were matched for age, sex ratio, and years of education. QOL was assessed using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), and regional hemodynamic responses during a verbal fluency task were monitored with near-infrared spectroscopy (NIRS). Patients with MDD-MF scored significantly lower than those with MDD-NMF on the role emotional domain of SF-36. Both MDD patient groups exhibited lower hemodynamic responses in the frontotemporal regions than the control group. Hemodynamic responses in the frontotemporal regions were significantly smaller in patients with MDD-MF than in those with MDD-NMF. The role emotional domain of patients with MDD-MF was significantly and positively correlated with hemodynamic responses in the prefrontal region, whereas that of patients with MDD-NMF revealed no significant correlation. In conclusion, our results indicate that patients with MDD-MF exhibit qualitatively distinct prefrontal dysfunction patterns associated with emotional role functioning compared with patients with MDD-NMF.
• Prefrontal cortex activation is associated with a discrepancy between self- and observer-rated depression severities of major depressive disorder: A multichannel near-infrared spectroscopy study

  Hiroyuki Akashi; Noa Tsujii; Wakako Mikawa; Toru Adachi; Eiji Kirime; Osamu Shirakawa

  JOURNAL OF AFFECTIVE DISORDERS ELSEVIER SCIENCE BV 174 165 - 172 0165-0327 2015/03 [Refereed]
   

  Background: Studies on major depressive disorder (MDD) show that the degree of correlation between the Beck Depression Inventory (BM) and Hamilton Depression Rating Scale (HAMD) varies widely. We aimed to determine whether this discrepancy reflects specific functional abnormalities in the frontotemporal cortex. Methods: Mildly depressed or euthymic patients with MDD (n=52), including 21 patients with MDD with the discrepancy, i.e., those with low HAMD(17) scores (<= 13) but high BDI-II scores (>28), and 31 patients without the discrepancy, i.e., those with low HAMD17 scores and low scores (<= 28), participated in the study along with 48 control subjects. Regional changes of oxygenated hemoglobin (oxy-Hb) levels during a verbal fluency task (VFT) were monitored using a 52-channel near-infrared spectroscopy (NIRS) device. Results: In the frontotemporal regions, mean oxy-Hb changes induced by the VET were significantly smaller in patients with MDD than in control subjects. In 5 channels within frontal regions, the increase in mean oxy-Hb levels was significantly greater in MDD patients with the BDI-HAMD discrepancy than in those without the discrepancy. In 6 channels within the frontal region of the patients with MDD, significant positive correlations were observed between mean oxy-Hb changes and BDI total scores (p = 0.38-0.59; P<0.05, false discovery rate corrected). Limitations: Our findings required replication in severely depressed patients, particularly those with melancholia. Conclusions: The distinct pattern of activation of the prefrontal cortex suggests that MDD with the BDI-HAMD discrepancy is pathophysiologically different from MDD without the discrepancy. (C) 2014 Elsevier B.V. All rights reserved.
• Left temporal activation associated with depression severity during a verbal fluency task in patients with bipolar disorder: a multichannel near-infrared spectroscopy study.

  Wakako Mikawa; Noa Tsujii; Hiroyuki Akashi; Toru Adachi; Eiji Kirime; Osamu Shirakawa

  Journal of affective disorders 173 193 - 200 2015/03 

  BACKGROUND: Neuroimaging studies using multichannel near-infrared spectroscopy (NIRS) have provided compelling evidence about the dysfunction of the frontotemporal cortices in patients with bipolar disorder (BD). However, it remains unclear whether the dysfunction is associated with mood state or symptom severity. Using NIRS, we aimed to clarify differences in oxygenated hemoglobin (oxy-Hb) activation between depressive and euthymic states as well as regional brain dysfunction in relation to symptom severity in BD. METHODS: Fifty-five patients with BD, including 30 with bipolar depression (BPD) and 25 with euthymic bipolar disorder (BPE), and 28 healthy controls (HCs) participated in the study. Regional hemodynamic changes during a verbal fluency task (VFT) were monitored using a 52-channel NIRS apparatus. RESULTS: The mean oxy-Hb changes induced by VFT were significantly smaller in the BD patients than in the HCs in 18 channels in the frontotemporal regions (false-discovery rate p<0.05, p=0.000-0.011). The BPD group exhibited significantly smaller changes in mean oxy-Hb compared with the BPE group in three channels of the left temporal region (p=0.005-0.014). In the BD patients, significant negative correlations were observed between mean oxy-Hb changes in the left temporal regions and the severity of depression. LIMITATIONS: Our sample size was small, making the results susceptible to type II errors. CONCLUSIONS: BD patients have persistent hypofunction of the frontotemporal cortical regions. Moreover, the hemodynamic response in the left temporal regions is associated with symptom severity.
• Right temporal activation differs between melancholia and nonmelancholic depression: a multichannel near-infrared spectroscopy study.

  Noa Tsujii; Wakako Mikawa; Hiroyuki Akashi; Emi Tsujimoto; Toru Adachi; Eiji Kirime; Masahiko Takaya; Masaya Yanagi; Osamu Shirakawa

  Journal of psychiatric research 55 1 - 7 2014/08 

  The aim of this study was to determine whether melancholia differs from nonmelancholic depression in frontotemporal functioning by means of multichannel near-infrared spectroscopy. We recruited 32 major depressive disorder (MDD) patients with melancholic features (MDD-MF), 28 MDD patients with nonmelancholic features (MDD-NMF), and 24 healthy controls. Regional hemodynamic changes induced by a verbal fluency task (VFT) were monitored, and their correlations with depressive symptoms were examined. In comparison with the controls, significant differences were observed in mean oxygenated hemoglobin (oxy-Hb) changes induced by VFT in patients with MDD-MF in 25 channels (p = 0.000-0.047) and in those with MDD-NMF in 12 channels (p = 0.000-0.023). Moreover, patients with MDD-MF had significantly smaller mean oxy-Hb changes than those with MDD-NMF in 8 channels of the right temporal region (p = 0.001-0.048). No significant correlations were observed between mean oxy-Hb changes and the Hamilton rating scale for depression (HAMD) 17 total score in both groups of patients with MDD. On examining each item of HAMD17, psychomotor retardation in patients with MDD-MF showed a significant positive correlation with mean oxy-Hb changes in the right temporal region (ch43; ρ = 0.55; p = 0.001), whereas that in patients with MDD-NMF showed a significant negative correlation with mean oxy-Hb changes in the frontal and left temporal regions in 3 channels (ρ = -0.60 to -0.53; p = 0.000-0.004). In conclusion, our results indicate that melancholia is qualitatively distinct from nonmelancholic depression both clinically and biologically.
• Discrepancy between self- and observer-rated depression severities as a predictor of vulnerability to suicide in patients with mild depression.

  Noa Tsujii; Hiroyuki Akashi; Wakako Mikawa; Emi Tsujimoto; Atsushi Niwa; Toru Adachi; Osamu Shirakawa

  Journal of affective disorders 161 144 - 9 2014/06 

  BACKGROUND: Discrepancies in depression severity between the Hamilton Depression Rating Scale (HAMD) and the Beck Depression Inventory (BDI) have been reported. However, whether these discrepancies impact vulnerability to suicide in patients with major depressive disorder (MDD) remains unclear. METHODS: Patients with mild MDD (n=161) were enrolled in the study and divided into the following 3 groups: (1) patients with MDD with the discrepancy (n=45), i.e., those with low HAMD17 scores (8-13) and high BDI-II scores (≥29), (2) patients with MDD without the discrepancy (n=46), i.e., those with low HAMD17 scores and low BDI-II scores (≤28), and (3) patients not currently depressed (n=70), i.e., those with HAMD17 scores ≤7 (affective controls). We examined the relationship of demographic, clinical, and neuropsychological variables with any discrepancy between self-rating and observer rating. RESULTS: Patients with MDD with the discrepancy had significantly higher hopelessness than those without the discrepancy and affective controls. Verbal fluency task performance of patients with MDD with the discrepancy was significantly impaired compared with that of those without the discrepancy and affective controls. Stepwise logistic regression analysis revealed that a history of suicide attempt [odds ratio (OR), 3.57; 95% confidence interval (CI), 1.12-11.37] and hopelessness (OR, 1.23; 95% CI, 1.09-1.38) increased odds of the discrepancy. LIMITATIONS: Results require replication. CONCLUSIONS: Clinicians should examine discrepancies between self- and observer-rated depression severities, which are associated with vulnerability to suicide in patients with MDD, even if objectively evaluated as mild.

MISC

• 医療従事者対象のてんかん診療講義

  中野 直樹; 宮内 正晴; 西郷 和真; 露口 尚弘; 安達 融; 井庭 慶典; 上原 悠  てんかん研究  40-  (2)  432  -432  2022/08
• ブロナンセリン貼付剤が奏効した精神病性うつ病の1例

  森本 拓頌; 明石 浩幸; 仁木 晃大; 寺田 徹; 安達 融; 三川 和歌子; 本多 義治; 橋本 衛  精神神経学雑誌  124-  (3)  209  -209  2022/03
• 【不安症 レジデントが知っておきたい診断や治療のコツ!】さまざまな対応 気分障害と不安症

  安達 融; 辻井 農亜; 橋本 衛  精神科Resident  3-  (1)  56  -57  2022/02
• 多訴的な身体表現性障害の1例

  林 宏樹; 辻井 農亜; 安達 融; 山形 祥礼; 中田 翼; 三川 和歌子; 白川 治  精神神経学雑誌  123-  (10)  698  -698  2021/10
• Hamilton Rating Scale for Depression 7点以下のうつ病患者に残遺した抑うつ症状と生活の質との関連

  山形 祥礼; 辻井 農亜; 中田 翼; 寺田 徹; 三川 和歌子; 安達 融; 瀧川 清統; 白川 治  日本うつ病学会総会・日本認知療法・認知行動療法学会プログラム・抄録集  18回・21回-  389  -389  2021/07
• 【不安の精神医学】不安症/不安症状を併存した双極性障害の診立てと薬物療法

  山形 祥礼; 安達 融; 柳 雅也; 白川 治  最新精神医学  26-  (2)  133  -137  2021/03
• 【現代社会における不安の病理と対応】双極性障害における不安症状・不安症とその対応

  安達 融; 柳 雅也; 白川 治  精神科治療学  35-  (12)  1335  -1340  2020/12
• 統合失調症における自殺傾性と脳機能との関連

  安達 融; 辻井 農亜; 三川 和歌子; 阪中 聡一郎; 白川 治  日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集  50回・42回・4回-  174  -174  2020/08
• 統合失調症における自殺傾性と脳機能との関連

  安達 融; 辻井 農亜; 三川 和歌子; 阪中 聡一郎; 白川 治  日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集  50回・42回・4回-  174  -174  2020/08
• 【スマートな向精神薬の処方How-to】抗うつ薬のシンプルな処方のために考慮すべきこと

  安達 融; 柳 雅也; 白川 治  臨床精神薬理  23-  (2)  129  -136  2020/02
• 発作後もうろう状態で自殺企図に至った1例

  森本 拓頌; 安達 融; 明石 浩幸; 阪中 聡一郎; 辻井 農亜; 白川 治  精神神経学雑誌  122-  (1)  63  -63  2020/01
• シゾイドパーソナリティを背景としたうつ病に修正型電気けいれん療法(mECT)を施行した1例

  細見 史治; 安達 融; 林 宏樹; 西原 崇浩; 瀧川 清統; 矢野 貴詩; 白川 治  精神神経学雑誌  122-  (1)  62  -62  2020/01
• 発作後もうろう状態で自殺企図に至った1例

  森本 拓頌; 安達 融; 明石 浩幸; 阪中 聡一郎; 辻井 農亜; 白川 治  精神神経学雑誌  122-  (1)  63  -63  2020/01
• 修正型電気けいれん療法が著効した老年期うつ病の1例

  矢野 貴詩; 切目 栄司; 山形 祥礼; 柳 雅也; 丹羽 篤; 細見 史治; 安達 融; 白川 治  精神神経学雑誌  121-  (1)  65  -65  2019/01
• 光トポグラフィー検査の判定精度に影響を与えるうつ病患者の臨床背景について

  土屋 有希; 辻井 農亜; 三川 和歌子; 廣瀬 智之; 安達 融; 川久保 善宏; 細見 史治; 白川 治  精神神経学雑誌  (2018特別号)  S545  -S545  2018/06
• 精神病症状の治療に難渋した抗NMDA受容体抗体脳炎の1例

  井庭 慶典; 西野 裕貴; 船戸 契; 宮崎 紘平; 細見 史治; 安達 融; 岡田 満; 竹村 司  子どもの心とからだ  27-  (1)  100  -100  2018/05
• 抑肝散の関与が疑われた重篤な不整脈を伴う低カリウム血症の1例

  細見 史治; 高屋 雅彦; 明石 浩幸; 安達 融; 矢野 貴詩; 山形 祥礼; 白川 治  精神神経学雑誌  120-  (3)  232  -232  2018/03
• 統合失調症におけるコーピングスキルと抑うつ症状の関連

  安達 融; 細見 史治; 廣瀬 智之; 辻井 農亜; 白川 治  精神神経学雑誌  119-  (9)  705  -705  2017/09
• うつ病患者における完全寛解に関連する因子についての検討

  辻井 農亜; 三川 和歌子; 明石 浩幸; 安達 融; 廣瀬 智之; 川久保 善宏; 細見 史治; 白川 治  日本うつ病学会総会・日本認知療法・認知行動療法学会プログラム・抄録集  14回・17回-  270  -270  2017/07
• 抗NMDA-R抗体および抗GAD抗体を認めた自己免疫性脳炎の1例

  西野 裕貴; 宮崎 紘平; 船戸 契; 井庭 慶典; 細見 史治; 安達 融; 田中 恵子; 岡田 満; 竹村 司  大阪小児科学会誌  34-  (2)  14  -14  2017/06
• 統合失調症における攻撃性と脳機能との関連

  安達 融; 辻井 農亜; 三川 和歌子; 辻本 江美; 明石 浩幸; 川久保 善宏; 廣瀬 智之; 細見 史治; 白川 治  精神神経学雑誌  (2016特別号)  S355  -S355  2016/06
• メランコリー型うつ病におけるQOLと脳機能の関連

  辻井 農亜; 三川 和歌子; 辻本 江美; 明石 浩幸; 安達 融; 切目 栄司; 白川 治  日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集  37回・45回-  167  -167  2015/09
• Lamotrigineにより薬剤性過敏症症候群を呈した統合失調感情障害の1例

  安達 融; 切目 栄司; 廣瀬 智之; 佐藤 雅子; 大磯 直毅; 川田 暁; 辻井 農亜; 白川 治  精神科治療学  30-  (8)  1111  -1116  2015/08
• 精神病エピソード後の遷延する抑うつ症状に対してラモトリギンが著効した1例

  明石 浩幸; 切目 栄司; 安達 融; 阪中 総一郎; 三川 和歌子; 白川 治  精神神経学雑誌  117-  (8)  687  -687  2015/08
• メランコリー型うつ病におけるQOLの特性

  辻井 農亜; 三川 和歌子; 辻本 江美; 明石 浩幸; 安達 融; 川久保 善宏; 廣瀬 智之; 小野 久江; 白川 治  日本うつ病学会総会・日本認知療法学会プログラム・抄録集  12回・15回-  264  -264  2015/07
• 精神病患者の身体合併症治療に対する当院におけるリエゾン活動の現状と課題 統合失調症症例に対する経験から

  安達 融; 廣瀬 智之; 船津 浩二; 切目 栄司; 白川 治  精神神経学雑誌  117-  (2)  158  -158  2015/02
• メランコリー型うつ病における抑うつ症状とQOL 非メランコリー型うつ病との差異

  川久保 善宏; 辻井 農亜; 切目 栄司; 船津 浩二; 高屋 雅彦; 柳 雅也; 原田 毅; 三川 和歌子; 安達 融; 曽我 愛佳; 阪中 聡一郎; 廣瀬 智之; 丹羽 篤; 和田 照平; 白川 治  精神神経学雑誌  117-  (1)  56  -56  2015/01
• 双極性障害における抑うつ症状とQOL 単極性うつ病との差異

  廣瀬 智之; 辻井 農亜; 高屋 雅彦; 柳 雅也; 明石 浩幸; 三川 和歌子; 安達 融; 阪中 聡一郎; 白川 治  精神神経学雑誌  117-  (1)  64  -64  2015/01
• Lamotrigineにより薬剤性過敏症症候群を呈した統合失調感情障害の1例

  安達 融; 廣瀬 智之; 曽我 愛佳; 池田 真優子; 辻井 農亜; 切目 栄司; 白川 治  精神神経学雑誌  (2014特別)  S629  -S629  2014/06
• 【身体疾患に併発した精神障害への薬物療法II】抗うつ薬と一般治療薬の特に注意すべき薬物相互作用

  切目 栄司; 池田 真優子; 安達 融; 白川 治  精神科治療学  29-  (4)  501  -506  2014/04
• 精神運動興奮を呈し器質因の除外に難渋した1例

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• 【まぎらわしい2つの病態の見分け方】仮面うつ病vs.身体表現性障害

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• 青年期うつ病の抑制機能と臨床症状の関連 若年成人との比較

  辻井 農亜; 三川 和歌子; 安達 融; 丹羽 篤; 白川 治  日本児童青年精神医学会総会抄録集  54回-  380  -380  2013/10
• 気分障害における自他覚症状の乖離と自覚症状評価の重要性 先進医療「光トポグラフィー検査を用いたうつ症状の鑑別診断補助」の経験から

  辻井 農亜; 明石 浩幸; 三川 和歌子; 辻本 江美; 丹羽 篤; 安達 融; 高屋 雅彦; 切目 栄司; 小野 久江; 白川 治  精神医学  55-  (7)  653  -661  2013/07
• 統合失調症に発症したアルツハイマー型認知症に対するメマンチンの使用経験 抗精神病薬の減量が可能であった2例

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• 双極性障害患者における自殺傾性と抑制機能の関連

  辻井 農亜; 明石 浩幸; 切目 栄司; 三川 和歌子; 安達 融; 佐藤 篤; 白川 治  Bipolar Disorder  11-  25  -31  2013/06
• Lithiumとquetiapineとの併用により手指の振戦と痺れを認めた双極性障害の1例

  池田 真優子; 原田 毅; 船津 浩二; 安達 融; 切目 栄司; 白川 治  精神神経学雑誌  115-  (1)  107  -108  2013/01
• 児童青年期の広汎性発達障害患者の行動障害に対するaripiprazoleの治療効果

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  辻井 農亜; 三川 和歌子; 安達 融; 白川 治  日本児童青年精神医学会総会抄録集  53回-  246  -246  2012/10

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