小竹 武 (コタケ タケシ)
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COVID-19の拡大により,薬学実務実習中の症例解析報告会を集合形式からオンライン形式へと移行した.本報告では,オンライン形式の症例解析報告会の概要について紹介する.さらに,アンケート調査から明らかとなった報告会の有益性と問題点について議論する.オンライン報告会は,実習6週目と11週目に大阪鉄道病院から,実習生,評価担当者をZoom®で接続して実施した.83%の参加者は,参加の容易さ,時間的な利点などの理由でオンライン報告会を肯定していた.一方,一部の参加者は,集合研修での臨場感や参加者間のコミュニケーションが不十分な点から否定的であった.オンライン形式での開催は,病院-薬局-大学間で協働での教育ツールとして非常に有効な手段であると考えられる.しかし,参加者が如何に集合形式での雰囲気を作り出せるかなど課題解決が必要であることが示唆された.
Studies in rabbits have been performed to evaluate the intraocular pressure (IOP)-reducing effect of various anti-glaucoma eye drops and eye drops of latanoprost (LP), which is a selective agonist of prostaglandin F receptor (FP). However, the sensitivity and localization of FP receptors in the rabbit eye are different from those in humans, and studying the relationship between IOP regulation and FP receptors in rabbits is important for the evaluation of antiglaucoma eye drops. In this study, we investigated whether stimulation of FP receptors in rabbits affects the regulation of aqueous humour production via β receptors by using the LP and the β-blocker timolol (TM). Ocular hypertension was induced in the rabbits by the infusion of a 5% glucose solution (15 mL/kg). Although no reduction in IOP was observed after the instillation of saline and 0.005% LP, 0.5% TM eye drops significantly reduced IOP. The IOP-reducing effect, as measured by area under the curve (AUC∆IOP) in rabbits treated with TM eye drops, was 81.3% that of LP 0.005%/TM 0.5% fixed combination (LTFC) eye drops, and the TM concentration in the aqueous humour following the instillation of LTFC eye drops was similar to that of TM eye drops. These results show that the stimulation of FP receptors affects the production of aqueous humour via β receptors in rabbits, meaning the rabbit model is not suitable for the evaluation of anti-glaucoma eye drops with FP receptor activity, since this drug effect was not observed in humans.