KONDOH Takashi

    Department of Food Science and Nutrition Professor/Manager
Last Updated :2024/04/25

Researcher Information

Research funding number

  • 40574017

J-Global ID

Research Interests

  • 減塩   Food Experience   vagus nerve   visceral sensation   taste   dried bonito dashi   inosinate   glutamate   palatability   preference   umami   dashi   

Research Areas

  • Life sciences / Food sciences
  • Life sciences / Food sciences
  • Life sciences / Food sciences / Taste
  • Life sciences / Food sciences / behavioral neuroscience

Academic & Professional Experience

  • 2024/04 - Today  近畿大学アグリ技術革新研究所(兼任)
  • 2021/10 - Today  Department of Food Science and Nutrition, Faculty of Agriculture, Kindai UniversityLaboratory of Food ChemistryProfessor and Chairman
  • 2020/04 - Today  Kindai UniversityDepartment of Food Science and Nutrition, Faculty of AgricultureProfessor
  • 2009/04 - 2023/03  Nagoya City University医学部非常勤講師(兼任)
  • 2019/04 - 2020/03  Ajinomoto Co., Inc.Institute of Food Sciences and TechnologiesExecutive Specialist
  • 2017/07 - 2019/06  Ajinomoto Co., Inc.Institute for InnovationExecutive Professional
  • 2016/04 - 2017/06  Ajinomoto Co., Inc.Institute for InnovationSenior Principal Researcher
  • 2012/10 - 2016/03  Ajinomoto Co., Inc.Institute for InnovationPrincipal Researcher
  • 2009/10 - 2012/09  Kyoto UniversityAJINOMOTO Integrative Research for Advanced Dieting, Graduate School of AgricultureAssociate Professor
  • 2009/04 - 2009/09  Ajinomoto Co., Inc.Institute of Life SciencesPrincipal Researcher
  • 2005/04 - 2009/03  Ajinomoto Co., Inc.Institute of Life SciencesAjinomoto Certified Professional
  • 2002/04 - 2005/03  Ajinomoto Co., Inc.Institute of Life SciencesSenior Researcher
  • 1999/07 - 2002/03  Ajinomoto Co., Inc.Central Research LaboratoriesPrincipal Researcher
  • 1995/10 - 1999/06  Ajinomoto Co., Inc.Central Research LaboratoriesResearcher
  • 1990/10 - 1995/09  ERATO, Research Development Corporation of JapanNeural Research Group, Torii Nutrient-Stasis ProjectResearcher

Association Memberships

  • 日本食品・機械研究会   食欲・食嗜好研究会   Japan Society for Bioscience, Biotechnology, and Agrochemistry   The Japan Emotionology Society   The Japanese Association for the Study of Taste and Smell   

Published Papers

  • Quantitative analysis of umami-enhancement effect by adding NaCl
    Kana Tanaka; Haruka Katsuragawa; Takashi Kondoh
    日本味と匂学会誌 日本味と匂学会 31 (1) 2024/05 [Refereed]
     
    Addition of small amounts of NaCl or soy sauce on dashi enhances its palatability to a great extent. Here we hypothesized that NaCl enhances umami taste caused by monosodium L-glutamate (MSG) in humans. Fifteen healthy university students were used for sensory evaluations. MSG at 0.3% was employed as the basic standard solution (S0). Other 5 standard solutions were prepared with increased concentrations of 1.3-fold steps. Umami intensity and palatability of various salts on S0 (S0 + salts) were evaluated by comparing with 6 standard solutions. NaCl enhanced both umami intensity and palatability of MSG in a concentration-dependent manner. Other Na+ salts (Na2SO4, NaHCO3) on a molar basis also enhanced both umami intensity and palatability comparable to NaCl. The Cl- salts (MgCl2, CaCl2, KCl) showed only modest to weak enhancement of umami intensity with no increase in palatability. These results suggest there are Na+-dependent enhancing mechanisms for umami taste in humans.
  • Influences of dietary composition on preference for dried bonito dashi in mice
    Takashi Kondoh
    近畿大学農学部紀要 (57) 19 - 33 2024/04 [Refereed]
  • Takashi Kondoh
    Physiology & Behavior Elsevier BV 261 (114084) 1 - 9 0031-9384 2023/01 [Refereed]
     
    1. Exposure to 1-100% dashi enhanced subsequent dried bonito dashi preference. 2. Exposure to reconstituted dashi also enhanced subsequent dashi preference. 3. Exposure to 0.1% IMP produced modest enhancement of subsequent dashi preference. 4. Exposure to neither NaCl, MSG, histidine, lactic acid, nor glucose were effective. 5. IMP is a key substance that produces experience-based enhancement of preference..
  • Muneko Nishijo; Tai The Pham; Ngoc Thao Pham; Hai Thai Thu Duong; Ngoc Nghi Tran; Takashi Kondoh; Yoshikazu Nishino; Hiroshi Nishimaru; Quyet Ba Do; Hisao Nishijo
    Nutrients 13 (5) 2021/04 [Refereed][Invited]
     
    Dioxins have been suggested to induce inflammation in the intestine and brain and to induce neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), partly due to deficits in parvalbumin-positive neurons in the brain that are sensitive to inflammatory stress. Previously, we reported ADHD traits with increased aggressiveness in children with prenatal exposure to dioxins in Vietnam, whereas dried bonito broth (DBB) has been reported to suppress inflammation and inhibit aggressive behavior in animal and human studies. In the present study, we investigated the association between dioxin exposure and the prevalence of children with highly aggressive behaviors (Study 1), as well as the effects of DBB on the prevalence of children with highly aggressive behaviors (Study 2). METHODS: In Study 1, we investigated the effects of dioxin exposure on the prevalence of children with high aggression scores, which were assessed using the Children's Scale of Hostility and Aggression: Reactive/Proactive (C-SHARP) in dioxin-contaminated areas. The data were analyzed using a logistic regression model after adjusting for confounding factors. In Study 2, we performed nutritional intervention by administering DBB for 60 days to ameliorate the aggressiveness of children with high scores on the C-SHARP aggression scale. The effects of DBB were assessed by comparing the prevalence of children with high C-SHARP scores between the pre- and post-intervention examinations. RESULTS: In Study 1, only the prevalence of children with high covert aggression was significantly increased with an increase in dioxin exposure. In Study 2, in the full ingestion (>80% of goal ingestion volume) group, the prevalence of children with high covert aggression associated with dioxin exposure was significantly lower in the post-ingestion examination compared with in the pre-ingestion examination. However, in other ingestion (<20% and 20-79%) groups and a reference (no intervention) group, no difference in the prevalence of children with high covert aggression was found between the examinations before and after the same experimental period. CONCLUSIONS: The findings suggest that DBB ingestion may ameliorate children's aggressive behavior, which is associated with perinatal dioxin exposure.
  • ラットのかつおだし嗜好性に及ぼす飼料中の砂糖およびたんぱく質含量の影響
    近藤 高史
    近畿大学農学部紀要 近畿大学農学部 (54) 1 - 17 2021/04 [Refereed]
  • Takashi Kondoh; Tetsuro Matsunaga
    Physiology & Behavior 213 (112708) 1 - 10 2020/01 [Refereed]
     
    Dried bonito dashi is a traditional Japanese fish broth that enhances palatability of various dishes due to its specific flavor. The present study examined influences of dietary fat levels (10% vs. 45% fat), presentation order of dried bonito dashi (ascending vs. descending concentrations), and prior experience with dashi on subsequent dashi intake and preference using two-bottle choice tests in two rodent strains, Sprague-Dawley (SD) rats and C57BL/6 N (B6N) mice. In the ascending concentration tests, SD rats on a low fat diet preferred 10-100% dashi to water, whereas B6N mice showed a blunted preference for dashi. Consumption of a high fat diet reduced dashi preference in SD rats. The B6N mice on the high fat diet never preferred dashi at any concentration. In the descending concentration tests, SD rats on the low fat diet preferred dashi over a wide range (0.03-100% dashi). The B6N mice showed a trend similar to that of SD rats. Ingestion of the high fat diet in both strains reduced dashi preference in the descending concentration tests. However, introduction of the high fat diet to dashi experienced rats maintained on the low fat diet, reduced neither dashi intake nor dashi preference. Dashi intake affected neither high fat diet intake, caloric intake, nor preference for high fat diet. These results suggest that preference for dried bonito dashi is influenced at least by 1) dietary fat levels, 2) presentation order of dashi, and 3) prior experience with dashi.
  • Takashi Kondoh; Mitsuhiro Yoshimura; Satomi Sonoda; Hiroaki Fujihara; Tetsuro Matsunaga; Yoichi Ueta
    Nutritional Neuroscience 1 - 9 2019/10 [Refereed]
     
    ABSTRACTObjectives: Dried bonito dashi, a traditional Japanese fish broth made from dried bonito tuna, enhances food palatability due to its specific umami flavor characteristics. However, the pattern of brain activation following dashi ingestion has not been previously investigated. Methods: We mapped activation sites of the rat brain after intragastric loads of dried bonito dashi by measuring neuronal levels of the Fos protein, a functional marker of neuronal activation. Results: Compared to intragastric saline, intragastric dashi administration produced enhanced Fos expression in four forebrain regions: the medial preoptic area, subfornical organ, habenular nucleus, and central nucleus of the amygdala. Interestingly, the medial preoptic area was found to be the only feeding-related hypothalamic area responsive to dashi administration. Moreover, dashi had no effect in the nucleus accumbens and ventral tegmental area, two connected sites known to be activated by highly palatable sugars and fats. In the hindbrain, dashi administration produced enhanced Fos expression in both visceral sensory (caudal nucleus of the solitary tract, dorsal part of the lateral parabrachial nucleus, and area postrema) and autonomic (rostral ventrolateral medulla, and caudal ventrolateral medulla) sites. Discussion: The results demonstrate the activation of discrete forebrain and hindbrain regions following intragastric loads of dried bonito dashi. Our data suggest that the gut-brain axis is the principal mediator of the postingestive effects associated with the ingestion of dashi.
  • Eugene R Delay; Benjamin Weaver; Douglas R Lane; Takashi Kondoh
    Physiology & Behavior 199 127 - 136 2019/02 [Refereed]
     
    Dried bonito dashi is often used in Japanese cuisine with a number of documented positive health effects. Its major taste is thought to be umami, elicited by inosine 5'-monophosphate (IMP) and L-amino acids. Previously we found that lactic acid, a major component of dried bonito dashi, enhanced the contribution of many of these amino acids to the taste of dried bonito dashi, and reduced the contribution of other amino acids. In addition to amino acids, dried bonito dashi also has a significant mineral salt component. The present study used conditioned taste aversion methods with mice (all had compromised olfactory systems) to compare the taste qualities of dried bonito dashi with four salts (NaCl, KCl, CaCl2 and MgCl2), with and without lactic acid or citric acid. A conditioned taste aversion to 25% dried bonitio dashi generalized significantly to NaCl and KCl, with or without 0.9% lactic acid added but not when citric acid was added. Generalization of the CTA to dried bonito dashi was much stronger to the divalent salts, but when either lactic acid or citric acid was added, this aversion was eliminated. These results suggest that these salts contribute to the complex taste of dried bonito dashi and that both organic acids appear able to modify the tastes of divalent salts.
  • Undarmaa Jargalsaikhan; Hiroshi Nishimaru; Jumpei Matsumoto; Yusaku Takamura; Tomoya Nakamura; Etsuro Hori; Takashi Kondoh; Taketoshi Ono; Hisao Nishijo
    Nutritional Neuroscience 20 (10) 571 - 586 2017/12 [Refereed]
     
    OBJECTIVES: Emerging evidence suggests that traditional diets and nutrition have a significant impact on brain development, and could contribute to the promotion of mental health and prevention of psychiatric disorders in children and adolescents. Moreover, deficits in parvalbumin (PV)-immunoreactive and/or GABAergic neurons are closely associated with various psychiatric disorders in children and adolescents. To investigate the possible neural mechanisms of diet involvement in mental health, we analyzed the effects of dried-bonito dashi (Japanese fish broth) (DBD) on PV-immunoreactive neurons and emotional behaviors in young mice. METHODS: Male mice after weaning were fed DBD for 60 days, and tested with a resident-intruder test for aggressiveness and a forced swimming test for depression-like symptoms. After the behavioral testing, PV-immunoreactive neurons in the brain were immunohistochemically analyzed. RESULTS: The results indicated that DBD intake decreased aggressiveness and depression-like symptoms, and increased the densities of PV-immunoreactive neurons in the medial prefrontal cortex (mPFC), amygdala, hippocampus, and superior colliculus. These behavioral changes were correlated with the densities of PV-immunoreactive neurons in the mPFC, amygdala, and hippocampus. However, subdiaphragmatic vagotomy did not affect the effects of DBD on emotional behaviors, although it nonspecifically decreased the densities of PV-immunoreactive neurons. DISCUSSION: The results suggest that DBD might modulate emotional behaviors by promoting PV-immunoreactive and/or GABAergic neuronal activity through parallel routes. The present results highlight a new mechanism for diet involvement in brain functions, and suggest that DBD might have therapeutic potential for the promotion of mental health.
  • Munkhzul Davaasuren; Jumpei Matsumoto; Choijiljav Chinzorig; Tomoya Nakamura; Yusaku Takamura; Enrico Patrono; Takashi Kondoh; Taketoshi Ono; Hisao Nishijo
    Physiological Reports 3 (e12545) 1 - 16 2015/10 [Refereed]
     
    Previous behavioral studies have suggested that l-glutamate, an umami substance, is detected in the gut, and that this information regarding glutamate is conveyed from the gut to the amygdala and the lateral hypothalamus (LH) through the vagus nerve to establish glutamate preference. In this study, we investigated the roles of the amygdala and LH in the information processing of gut glutamate. We recorded the activity of amygdalar and LH neurons during the intragastric administration of five test solutions (monosodium l-glutamate [MSG, 60 mmol/L]; inosine monophosphate [IMP, 60 mmol/L]; a mixture of MSG and IMP; NaCl [60 mmol/L]; or physiological saline) in intact and subdiaphragmatic vagotomized awake rats. In intact rats, 349 and 189 neurons were recorded from the amygdala and LH, respectively, while in vagotomized rats, 104 and 90 neurons were recorded from the amygdala and LH, respectively. In intact rats, similar percentages of neurons (30-60%) in the amygdala and LH responded to the intragastric infusion of the solutions. Vagotomy significantly altered responses to the MSG and NaCl solutions. In particular, vagotomy suppressed the inhibitory responses to the NaCl solution. Furthermore, vagotomy increased the response similarity between the MSG and NaCl solutions, suggesting that vagotomy impaired the coding of the postingestive consequences of the MSG solution in the amygdala and LH, which are unique for glutamate. The present results provide the first neurophysiological evidence that amygdalar and LH neurons process glutamate signals from the gut.
  • Shoichiro Funatsu; Takashi Kondoh; Takahiro Kawase; Hiromi Ikeda; Mao Nagasawa; D Michael Denbow; Mitsuhiro Furuse
    Nutritional Neuroscience 18 (6) 256 - 264 2015/08 [Refereed]
     
    Dried bonito dashi, a traditional Japanese fish stock, enhances palatability of various dishes because of its specific flavor. Daily intake of dashi has also been shown to improve mood status such as tension-anxiety in humans. This study aimed at investigating beneficial effects of dashi ingestion on anxiety/depression-like behaviors and changes in amino acid levels in the brain and plasma in rats. Male Wistar rats were given either dried bonito dashi or water for long-term (29 days; Experiment 1) or single oral administration (Experiment 2). Anxiety and depression-like behaviors were tested using the open field and forced swimming tests, respectively. Concentrations of amino acids were measured in the hippocampus, hypothalamus, cerebellum, and jugular vein. During the long-term (29 days) consumption, rats given 2% dashi frequently entered the center zone and spent more time compared with the water controls in the open field test. However, the dashi was ineffective on depression-like behavior. In the hippocampus, concentrations of hydroxyproline, anserine, and valine were increased by dashi while those of asparagine and phenylalanine were decreased. In the hypothalamus, the methionine concentration was decreased. In a single oral administration experiment, the dashi (1%, 2% or 10%) showed no effects on behaviors. Significance was observed only in the concentrations of α-aminoadipic acid, cystathionine, and ornithine in the hippocampus. Dried bonito dashi is a functional food having anxiolytic-like effects. Daily ingestion of the dashi, even at lower concentrations found in the cuisine, reduces anxiety and alters amino acid levels in the brain.
  • Eugene R Delay; Takashi Kondoh
    Chemical Senses 40 (2) 125 - 40 2015/02 [Refereed]
     
    The primary taste of dried bonito dashi is thought to be umami, elicited by inosine 5'-monphosphate (IMP) and L-amino acids. The present study compared the taste qualities of 25% dashi with 5 basic tastes and amino acids using conditioned taste aversion methods. Although wild-type C57BL/6J mice with compromised olfactory systems generalized an aversion of dashi to all 5 basic tastes, generalization was greater to sucrose (sweet), citric acid (sour), and quinine (bitter) than to NaCl (salty) or monosodium L-glutamate (umami) with amiloride. At neutral pH (6.5-6.9), the aversion generalized to l-histidine, L-alanine, L-proline, glycine, L-aspartic acid, L-serine, and monosodium L-glutamate, all mixed with IMP. Lowering pH of the test solutions to 5.7-5.8 (matching dashi) with HCl decreased generalization to some amino acids. However, adding lactic acid to test solutions with the same pH increased generalization to 5'-inosine monophosphate, L-leucine, L-phenylalanine, L-valine, L-arginine, and taurine but eliminated generalization to L-histidine. T1R1 knockout mice readily learned the aversion to dashi and generalized the aversion to sucrose, citric acid, and quinine but not to NaCl, glutamate, or any amino acid. These results suggest that dashi elicits a complex taste in mice that is more than umami, and deleting T1R1 receptor altered but did not eliminate their ability to taste dashi. In addition, lactic acid may alter or modulate taste transduction or cell-to-cell signaling.
  • Tetsuro Matsunaga; Shiho Li; Tetsuya Adachi; Erina Joo; Ning Gu; Hanae Yamazaki; Koichiro Yasuda; Takashi Kondoh; Kinsuke Tsuda
    Bioscience, Biotechnology, and Biochemistry 78 (5) 843 - 50 2014/05 [Refereed]
     
    Chronic hyperglycemia has deleterious effects on pancreatic β-cell function, a process known as glucotoxicity. This study examined whether chronic high glucose (CHG) induces cellular hypoxia in rat INS-1 β cells, and whether hyperoxia (35% O2) can reverse glucotoxicity-induced inhibition of insulin secretion. CHG (33.3 mm, 96 h) reduced insulin secretion, and down-regulated insulin and pancreatic duodenal homeobox factor 1 gene expression. CHG also increased intracellular pimonidazole-protein adducts, a marker for hypoxia. CHG also enhanced hypoxia-inducible factor 1α (HIF-1α) protein expression and its DNA-binding activity, which was accompanied by a decrease in mRNA expression of glucose transporter 2 (GLUT2), glucokinase and uncoupling protein-2 and an increase in mRNA expression of GLUT1 and pyruvate dehydrogenase kinase 1. Hyperoxia restored the decrease in insulin secretion and the gene expression except for GLUT2, and suppressed intracellular hypoxia and HIF-1α activation. These results suggest that glucotoxicity may cause β-cell hypoxia. Hyperoxia might prevent glucotoxicity-induced β-cell dysfunction and improve insulin secretion.
  • Effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on development of taste preference in rat offspring.
    Muneko Nishijo; Jun-ichi Kuriwaki; Tran Ngoc Nghi; Hideaki Nakagawa; Kunio Torii; Takashi Kondoh; Hisao Nishijo
    Journal of Addiction Research & Therapy 5 (173) 1 - 6 2014/02 [Refereed]
  • Karen Ackroff; Takashi Kondoh; Anthony Sclafani
    Chemical Senses 39 (2) 159 - 66 2014/02 [Refereed]
     
    The flavor of dashi, the broth prepared from dried bonito tuna, is attractive to humans and rodents. The present experiments examined the ability of dashi to serve as an oral and/or postoral rewarding stimulus for conditioned flavor preferences in mice. In Experiment 1, C57BL/6J (B6) mice were infused intragastrically with dashi when they consumed a conditioned stimulus (CS)+ flavor and with water when they drank a CS- flavor on alternate days. Postoral dashi did not condition a CS+ preference. The combined effects of oral and postoral dashi exposure were examined in Experiment 2, in which B6 mice consumed a CS+ flavored dashi solution and CS- flavored water on alternate days. The mice did not prefer the CS+ to CS- when both flavors were presented in water. Yet, the B6 mice in both experiments preferred dashi to water in oral tests. Experiment 3 showed that taste-impaired Trpm5 knockout (KO) mice did not learn to prefer dashi after exposure to it, in contrast to previous findings with the umami prototype monosodium glutamate. This was not due to an inability to taste dashi, because Trpm5 KO mice learned a strong preference for dashi after it was mixed with glucose. The impact of dashi on reward may largely reflect an enhancement of association of oral and postoral effects of food.
  • Kondoh Takashi; Kazuhiro Nakamura
    The Japanese Journal of Taste and Smell Research The Japanese Association for the Study of Taste and Smell 19 (2) 223 - 229 1340-4806 2012/08 [Refereed]
     
    Taste components in liquid released from salt-pickled suguki (Brassica rapa var. neosuguki; a traditional vegetable in Kyoto, Japan) were analyzed to clarify why the liquid is tasty. The liquid contained an approximately 4-fold higher amount of glutamate (an umami substance) than that in kelp dashi (broth) or other kinds of dashi. However, the liquid from salt-pickled giant turnips (Brassica rapa; omi-kabura) as a control also contained a comparable amount of glutamate to that from pickled suguki, suggesting that components other than glutamate would differentiate the palatability between liquids from pickled suguki and pickled turnips. Compared with pickled turnip liquid, pickled suguki liquid contained significantly higher amounts of sweet amino acids, total amino acids, lactate and minerals such as Ca, Mg, Fe, and inorganic phosphorus. Stimulation of gustatory sweet and sour receptors and extracellular calcium-sensing receptors by these components may produce the well-balanced sweetness, sourness and kokumi of pickled suguki liquid.
  • Tetsuro Matsunaga; Ayae Shoji; Ning Gu; Erina Joo; Shiho Li; Tetsuya Adachi; Hanae Yamazaki; Koichiro Yasuda; Takashi Kondoh; Kinsuke Tsuda
    Molecular Medicine Reports 5 (4) 905 - 9 2012/04 [Refereed]
     
    Tocotrienols, members of the vitamin E family, have been shown to possess anti-inflammatory properties and display activity against a variety of chronic diseases, such as cancer, cardiovascular and neurological diseases. However, whether tocotrienols contribute to the prevention of inflammatory responses in adipose tissue remains to be elucidated. In this study, we examined the effects of γ-tocotrienol, the most common tocotrienol isomer, on tumor necrosis factor-α (TNF-α)-induced inflammatory responses by measuring the expression of the adipokines, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes. Exposure to TNF-α (10 ng/ml) for 24 h increased MCP-1 and IL-6 secretion, and decreased adiponectin secretion and peroxisome proliferator-activated receptor-γ (PPARγ) mRNA expression. γ-tocotrienol effectively improved the TNF-α-induced adverse changes in MCP-1, IL-6 and adiponectin secretion, and in MCP-1, IL-6, adiponectin and PPARγ mRNA expression. Furthermore, TNF-α-mediated IκB-α phosphorylation and nuclear factor-κB (NF-κB) activation were significantly suppressed by the γ-tocotrienol treatment. Our results suggest that γ-tocotrienol may improve obesity-related functional abnormalities in adipocytes by attenuating NF-κB activation and the expression of inflammatory adipokines.
  • H. Otsubo; T. Kondoh; M. Shibata; K. Torii; Y. Ueta
    Neuroscience Elsevier BV 196 97 - 103 0306-4522 2011/11 [Refereed]
  • Anh Son Ho; Etsuro Hori; Phuong Hong Thi Nguyen; Susumu Urakawa; Takashi Kondoh; Kunio Torii; Taketoshi Ono; Hisao Nishijo
    Hippocampus 21 (5) 502 - 19 2011/05 [Refereed]
     
    Neuroanatomical studies suggest that hippocampal formation (HF) receives information from all sensory modalities including taste via the parahippocampal cortices. To date, however, no neurophysiological study has reported that HF neurons encode taste information. In the present study, we recorded CA1 HF neurons from freely behaving rats during performance of a visually-guided licking task in two different triangular chambers. When a cue lamp came on, the rats were required to press a bar to trigger a tube to protrude into the chambers for 3 s. During this period, the rats could lick one of six sapid solutions: [0.1M NaCl (salty), 0.3M sucrose (sweet), 0.01 M citric acid (sour), 0.0001 M quinine HCl (bitter), 0.01 M monosodium L-glutamate (MSG, umami), and a mixture of MSG and 0.001 M disodium-5'-inosinate (IMP) (MSG+IMP)], and distilled water. Of a total 285 pyramidal and interneurons, the activity of 173 was correlated with at least one of the events in the task-illumination of cue lamps, bar pressing, or licking the solution. Of these, 137 neurons responded during licking, and responses of 62 of these cells were greater to sapid solutions than to water (taste neurons). Multivariate analyses of the taste neurons suggested that, in the HF, taste quality might be encoded based on hedonic value. Furthermore, the activity of most taste neurons was chamber-specific. These results implicate the HF in guiding appetitive behaviors such as conditioned place preference.
  • Takashi Kondoh; Yoichi Ueta; Kunio Torii
    Brain Research Bulletin 84 (1) 69 - 74 2011/01 [Refereed]
     
    Recent studies suggest the protective effects of adrenomedullin (AM) on ischemic brain damage. The present study was aimed at investigating the effects of AM and its receptor antagonist, AM₂₂₋₅₂, on ischemia-induced cerebral edema and brain swelling in rats using magnetic resonance imaging. Rats were subjected to 60 min of middle cerebral artery occlusion (MCAO) followed by reperfusion. Intravenous injection of AM (1.0 μg/kg), AM₂₂₋₅₂ (1.0 μg/kg), or saline was made before MCAO. Effects of AM injection just after reperfusion were also investigated. One day after ischemia, increases in T₂-weighted signals in the brain were clearly observed. Total edema volume, as well as brain swelling, was greatly and significantly reduced by pre-treatment of AM (reduced by 53%). Extent of brain swelling was significantly correlated with the volume of cerebral edema. The protective effect of AM against edema was more clearly observed in the cerebral cortex (reduced by 63%) than the striatum (reduced by 31%). Increased T₂ relaxation time in the cortex was recovered partially by pre-treatment of AM. Post-treatment of AM had no effects. Pre-treatment of AM₂₂₋₅₂ tended to exacerbate the edema. In another line of experiment, cocktail administration of AM with melatonin, a pineal product having neuroprotective potential as a free radical scavenger, failed to enhance the protective effects of AM alone. The present study clearly suggests the prophylactic effects of AM against cerebral edema, especially the cortical edema, in a rat stroke model.
  • Xueying Ren; Jozélia G Ferreira; Catherine W Yeckel; Takashi Kondoh; Ivan E de Araujo
    Digestion 83 Suppl 1 32 - 6 2011 [Refereed]
     
    Although the umami compound monosodium glutamate (MSG) is a widely used flavor enhancer, controversy still persists regarding the effects of MSG intake on body weight. It has been claimed, in particular, that chronic MSG intake may result in excessive body weight gain and obesity. In this study we assessed the effects of chronic (16 weeks) ad libitum MSG on body weight and metabolism of C57BL6/J mice. Adult male mice were divided in four experimental groups and fed with either a low-fat (LF) or high-fat (HF) diet and with either two bottles of plain water or one bottle containing 1% MSG and another one containing water according to a factorial design. Mice were monitored weekly for body weight and food/fluid intake for 15 weeks. At the end of the experiments, the circulating levels of leptin, insulin, total protein, total cholesterol, triglyceride, blood urea nitrogen, and non-esterified fatty acids were also analyzed. Our results show that MSG intake did not influence body weight in either LF or HF groups. Interestingly, although animals overall displayed strong preferences for MSG against water, preferences were relatively higher in LF compared to HF group. Consistent with the body weight data, while significant differences in leptin, insulin, total cholesterol, and non-esterified fatty acids were found between HF and LF groups, such an effect was not influenced by MSG intake. Finally, indirect calorimetry measurements revealed similar energy expenditure levels between animals being presented water only and MSG only. In summary, our data does not support the notion that ad libitum MSG intake should trigger the development of obesity or other metabolic abnormalities.
  • Glycine enhances glutamate-induced excitation in ventromedial hypothalamic neurons of awake rats.
    Hruda Nanda Mallick; Takashi Kondoh; Hisao Nishijo; Taketoshi Ono; Kunio Torii
    Indian Journal of Physiology and Pharmacology 54 (4) 355 - 360 2010/10 [Refereed]
  • Takashi Kondoh; Makiko Kameishi; Hruda Nanda Mallick; Taketoshi Ono; Kunio Torii
    Frontiers in Integrative Neuroscience 4 (18) 1 - 10 2010/01 [Refereed]
     
    Intravenous administration of arginine was shown to be protective against cerebral ischemic insults via nitric oxide production and possibly via additional mechanisms. The present study aimed at evaluating the neuroprotective effects of oral administration of lysine (a basic amino acid), arginine, and their combination on ischemic insults (cerebral edema and infarction) and hemispheric brain swelling induced by transient middle cerebral artery occlusion/reperfusion in rats. Magnetic resonance imaging and 2,3,5-triphenyltetrazolium chloride staining were performed 2 days after ischemia induction. In control animals, the major edematous areas were observed in the cerebral cortex and striatum. The volumes associated with cortical edema were significantly reduced by lysine (2.0 g/kg), arginine (0.6 g/kg), or their combined administration (0.6 g/kg each). Protective effects of these amino acids on infarction were comparable to the inhibitory effects on edema formation. Interestingly, these amino acids, even at low dose (0.6 g/kg), were effective to reduce hemispheric brain swelling. Additionally, the effects of in vivo microiontophoretic (juxtaneuronal) applications of these amino acids on glutamate-evoked neuronal activity in the ventromedial hypothalamus were investigated in awake rats. Glutamate-induced neuronal activity was robustly inhibited by microiontophoretic applications of lysine or arginine onto neuronal membranes. Taken together, our results demonstrate the neuroprotective effects of oral ingestion of lysine and arginine against ischemic insults (cerebral edema and infarction), especially in the cerebral cortex, and suggest that suppression of glutamate-induced neuronal activity might be the primary mechanism associated with these neuroprotective effects.
  • Takashi Kondoh; Hruda Nanda Mallick; Kunio Torii
    The American journal of clinical nutrition 90 (3) 832S - 837S 2009/09 [Refereed][Invited]
     
    l-Glutamate is a multifunctional amino acid involved in taste perception, intermediary metabolism, and excitatory neurotransmission. In addition, recent studies have uncovered new roles for l-glutamate in gut-brain axis activation and energy homeostasis. l-Glutamate receptors and their cellular transduction molecules have recently been identified in gut epithelial cells. Stimulation of such l-glutamate receptors by luminal l-glutamate activates vagal afferent nerve fibers and then parts of the brain that are targeted directly or indirectly by these vagal inputs. Notably, 3 areas of the brain-the medial preoptic area, the hypothalamic dorsomedial nucleus, and the habenular nucleus-are activated by intragastric l-glutamate but not by glucose or sodium chloride. Furthermore, the chronic, ad libitum ingestion of a palatable solution of monosodium l-glutamate (1% wt:vol) by rats has also been found to reduce weight gain, fat deposition, and plasma leptin concentrations compared with rats that ingest water alone. No difference in food intake was observed. Such effects may also be vagally mediated. Together, such findings contribute to the growing knowledge base that indicates that l-glutamate signaling via taste and gut l-glutamate receptors may influence multiple physiologic functions, such as thermoregulation and energy homeostasis.
  • Tomokazu Tsurugizawa; Akira Uematsu; Eiji Nakamura; Mai Hasumura; Mariko Hirota; Takashi Kondoh; Hisayuki Uneyama; Kunio Torii
    Gastroenterology 137 (1) 262 - 273 2009/07 [Refereed]
     
    BACKGROUND & AIMS: The gut-brain axis, which transmits nutrient information from the gastrointestinal tract to the brain, is important for the detection of dietary nutrients. We used functional magnetic resonance imaging of the rat forebrain to investigate how this pathway conveys nutrient information from the gastrointestinal tract to the brain. METHODS: We investigated the contribution of the vagus nerve by comparing changes of blood oxygenation level-dependent signals between 24 control rats and 22 rats that had undergone subdiaphragmatic vagotomy. Functional data were collected under alpha-chloralose anesthesia continuously 30 minutes before and 60 minutes after the start of intragastric infusion of L-glutamate or glucose. Plasma insulin, L-glutamate, and blood glucose levels were measured and compared with blood oxygenation level-dependent signals. RESULTS: Intragastric administration of L-glutamate or glucose induced activation in distinct forebrain regions, including the cortex, hypothalamus, and limbic areas, at different time points. Vagotomy strongly suppressed L-glutamate-induced activation in most parts of the forebrain. In contrast, vagotomy did not significantly affect brain activation induced by glucose. Instead, blood oxygenation level-dependent signals in the nucleus accumbens and amygdala, in response to gastrointestinal glucose, varied along with fluctuations of plasma insulin levels. CONCLUSIONS: These results indicate that the vagus nerve and insulin are important for signaling the presence of gastrointestinal nutrients to the rat forebrain. These signal pathways depend on the ingested nutrients.
  • Ryoko Shibata; Makiko Kameishi; Takashi Kondoh; Kunio Torii
    Physiology & Behavior 96 (4-5) 667 - 674 2009/03 [Refereed]
     
    The role of the dopaminergic cells in the ventral tegmental area (VTA) in response to natural rewards is important in understanding palatability-induced feeding behavior. In this study, we first investigated whether dopaminergic lesions in the VTA would influence the taste preferences of rats for sodium chloride (NaCl), monosodium glutamate (MSG), disodium inosine-5'-monophosphate (IMP), disodium guanine-5'-monophosphate (GMP) and sucrose. Among these taste stimuli, only the preference of sucrose solutions decreased significantly in the VTA lesioned rats, preferences for the other taste stimuli were unaffected. Secondly, we tested whether VTA lesioned rats made slightly deficient in the amino acid lysine (by feeding rats a lysine deficient diet for five days) would detect the deficient amino acid in a choice test. Both the VTA lesioned rats and the control rats chose to consume the lysine solution and there was no difference between these two groups. These results suggest that the dopaminergic neurons in the VTA influence sucrose consumption, but do not alter the consumption of palatable umami compounds and salt. They also do not inhibit the animal's ability to recognize the essential amino acid lysine when the animal is deficient in it. Different central pathways must underlie sucrose preference and preferences for these amino acids and ribonucleotides.
  • Akira Uematsu; Tomokazu Tsurugizawa; Takashi Kondoh; Kunio Torii
    Neuroscience Letters 451 (3) 190 - 193 2009/02 [Refereed]
     
    The preference for foods or fluids in rats is partly dependent on its postingestive consequences. Many studies have investigated postingestive effect of high caloric substances, such as carbohydrate or fat. In this study, we examined postingestive effect of L-glutamate at the preferable concentration using conditioned flavor preference paradigm. Adult male rats with chronic intragastric (IG) cannula were trained to drink a flavored solution (conditioned stimulus; CS+) paired with IG infusion of nutrient solution and another flavored solution (CS-) with IG distilled water infusion on alternate days. The nutrient solution was 60mM monosodium L-glutamate, sodium chloride or glucose. Before and after conditioning, rats received 30min two-bottle choice tests for CS+ and CS- solution. All groups exhibited no significant preference for CS+ in pre-test period. By the last half of conditioning period, intake of CS+ solution was significantly higher than that of CS- in MSG group, but not in NaCl and glucose groups. After conditioned, the MSG group showed significantly higher intake and preference for CS+ solution (69.9%), while the NaCl and glucose group did not show any significant intake and preference for CS+ solution (50.9%, 43.5%, respectively). These results indicate that the amino acid L-glutamate at a preferable concentration has a positive postingestive effect as demonstrated by its ability to condition a flavor preference. The mechanism(s) for this positive effect could be through a direct effect on gut Glu receptors rather than the provision of calories or glucose from metabolized Glu; Further studies are needed to test these hypotheses.
  • Physiological significance of glutamate signaling in gut-brain communication.
    Takashi Kondoh; Hruda Nanda Mallick; Kunio Torii
    Bioscience Microflora 28 (4) 109 - 118 2009 [Invited]
  • Takashi Kondoh; Tomokazu Tsurugizawa; Kunio Torii
    INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE WILEY-BLACKWELL 1170 77 - 81 0077-8923 2009 [Refereed][Invited]
     
    Recent studies have demonstrated the existence of receptors for L-glutamate (GLU) and their transduction molecules in the gut mucosa as well as in the oral cavity. Among 20 amino acids, gastric vagal afferent fibers respond only to intragastric administration of GLU. Functional magnetic resonance imaging revealed activation of several fore-brain regions in response to intragastric infusion of taste solutions (D-glucose [sweet], monosodium L-glutamate [MSG; umami], and NaCl [salty] at 60 mM) in rats. Glucose activated the nucleus accumbens. MSG activated the medial preoptic area, dorsomedial nucleus of the hypothalamus, and habenular nucleus. Both glucose and MSG activated the amygdala. Some areas, such as the insular cortex, anterior cingulate cortex, hippocampus, and caudate-putamen were activated by all three substances. Glucose-induced brain activation developed slowly and persisted for a long time, whereas activation by MSG developed rapidly during infusion and reduced rapidly after cessation of infusion. NaCl induced only small and transient activation. Thus, both activated areas and temporal response patterns in the brain were distinct between sweet and umami substances delivered in the stomach. Postoral taste substances may activate the brain via neural (vagal) and/or humoral pathways.
  • Takashi Kondoh; Kunio Torii
    Biological and Pharmaceutical Bulletin The Pharmaceutical Society of Japan 31 (10) 1827 - 1832 0918-6158 2008/10 [Refereed][Invited]
     
    Monosodium L-glutamate (MSG) elicits a unique taste termed umami and is widely used as a flavor enhancer in a variety of cuisines. Recent studies suggest the existence of L-glutamate (GLU) receptors and its transduction molecules in the gut mucosa as well as in the oral cavity. The vagal gastric afferent fibers respond specifically to the luminal stimulation of GLU in the stomach. GLU administration in the stomach also activates several brain areas (insular cortex, basal ganglia, limbic system, and hypothalamus). Ingestion of MSG enhanced secretion of digestive juices and insulin. Spontaneous ingestion of an MSG solution at the most preferred concentration (1% (w/v)) reduced weight gain, fat deposition, and plasma leptin levels without affecting food intake, naso-anal length (an index of somatic development), and lean mass in rats. These results suggest that umami signaling via gustatory and visceral pathways may play an important role in the process of digestion, absorption, metabolism, and other physiological functions via activation of the brain.
  • Takashi Kondoh; Kunio Torii
    Physiology & Behavior 95 (1-2) 135 - 44 2008/09 [Refereed]
     
    Monosodium l-glutamate (MSG), an umami taste substance, may be a key molecule coupled to a food intake signaling pathway, possibly mediated through a specific l-glutamate (GLU) sensing mechanism in the gastrointestinal tract. Here we investigated the effect of the spontaneous ingestion of a 1% MSG solution and water on food intake and body weight in male Sprague-Dawley rats fed diets of varying caloric density, fat and carbohydrate contents. Fat mass and lean mass in the abdomen, blood pressure, and several blood metabolic markers were also measured. Rats given free access to MSG and water showed a high preference (93-97%) for the MSG solution, regardless of the diet they consumed. Rats ingesting MSG had a significantly smaller weight gain, reduced abdominal fat mass, and lower plasma leptin levels, compared to rats ingesting water alone. Naso-anal length, lean mass, food and energy intakes, blood pressure, blood glucose, and plasma levels of insulin, triglyceride, total cholesterol, albumin, and GLU were not influenced by the ingestion of the MSG solution. These same effects were observed in a study of adult rats. Together, these results suggest that MSG ingestion reduces weight gain, body fat mass, and plasma leptin levels. Moreover, these changes are likely to be mediated by increased energy expenditure, not reduced energy intake or delayed development. Conceivably, these effects of MSG might be mediated via gut GLU receptors functionally linked to afferent branches of the vagus nerve in the gut, or the afferent sensory nerves in the oral cavity.
  • Tomokazu Tsurugizawa; Takashi Kondoh; Kunio Torii
    Neuroreport 19 (11) 1111 - 5 2008/07 [Refereed]
     
    Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastric administration of glucose, L-glutamate, and NaCl. These dietary nutrients led to a significant activation in the forebrain regions including nucleus accumbens, hypothalamic area, and limbic system with different timings. These data indicate that several forebrain regions have important roles on perception and process of postingestive nutrient information.
  • Takashi Kondoh; Makoto Bannai; Hitoo Nishino; Kunio Torii
    Experimental Neurology 192 (1) 194 - 202 0014-4886 2005/03 [Refereed]
     
    Injection with 6-hydroxydopamine (6-OHDA) into the nigrostriatal pathway results in loss of nigrostriatal dopaminergic neurons, which has been used widely as an animal model of Parkinson's disease. In the present study, location and extent of lesions 1 day after 6-OHDA injections (2, 4, 8, or 16 microg as a free base) in the substantia nigra (SN) were evaluated in rats by T(2)-weighted magnetic resonance imaging (MRI). The changes in MRI were also compared to immunohistochemical and behavioral changes. Hyperintense area in MRI was found at the region corresponding to 6-OHDA injection in a dose-dependent manner and was accompanied by a loss of tyrosine hydroxylase (TH)-positive cells. The shape of hyperintense area in the SN appeared to be composed of two components (i.e., circular and longitudinal regions). Administration of a larger dose of 6-OHDA (8-16 microg) was accompanied by an increase in hyperintense area and loss of TH-positive cells beyond the SN. The hyperintense area was observed on the first and third days after 6-OHDA injection, but the size and intensity declined to near normal levels on the ninth day. Rotational behavior induced by methamphetamine reached maximal levels at 4 microg 6-OHDA, and the behavior was maintained with doses up to 16 microg of 6-OHDA. Intrastriatal injection with 6-OHDA was less effective. These results suggest that MRI provides highly valuable information for verifying the size and location of intended lesions as well as for determining the optimal dose of neurotoxins in individual animals.
  • Takashi Kondoh; Shuori Yamada; Seiji Shioda; Kunio Torii
    Chemical Senses 30 Suppl 1 i172 - i173 2005/01 [Refereed][Invited]
  • Jun-ichi Kuriwaki; Hisao Nishijo; Takashi Kondoh; Teruko Uwano; Kunio Torii; Motoya Katsuki; Taketoshi Ono
    Neurosignals S. Karger AG 13 (5) 227 - 240 1424-862X 2004/09 [Refereed]
  • 磯村 健一; 間瀬 光人; 片野 広之; 藤田 政隆; 相原 徳孝; 近藤 高史; 鳥居 邦夫; 山本 直樹; 浅井 清文; 西野 仁雄; 山田 和雄
    Nagoya Medical Journal 名古屋市立大学大学院医学研究科 46 (4) 181 - 194 0027-7649 2004/01 [Refereed]
     
    カオリン誘発性ラット水頭症におけるアクアポリン(AQP)-1および4の発現について調べた.カオリン注射の2,4および9週後の時点でAQP-1 mRNAの誘導が認められ,脳室拡張の進展に伴い徐々に増大した.AQP-1蛋白の発現も同じ場所で同じ時間経過で発現したが,徐々に増加することはなかった.遺伝子および蛋白の発現は共に,CSFシャント後ダウンレギュレーションされた.AQP-4のmRNAまたは蛋白の発現はどの時間で見ても,脳組織のどの部分でも増大しなかった.本研究は,カオリンで誘導したラットの実験的水頭症においてアクアポリンAQP-1の遺伝子および蛋白は発現するが,AQP-4については発現しないことを示した.AQP-1の発現は,CSF循環障害により生じたうっ血に対処するために起こるものと考えられる.以上,AQP-1の調節が水頭症治療のために,有用であることが示唆された
  • Kunio Torii; Hisayuki Uneyama; Hitoo Nishino; Takashi Kondoh
    Journal of Pineal Research 36 (1) 18 - 24 0742-3098 2004/01 [Refereed]
     
    Melatonin, a pineal secretory product synthesized from tryptophan, has been found to be effective against neurotoxicity. The present study was aimed at demonstrating the effectiveness of melatonin in vivo in reducing ischemia-induced cerebral edema using magnetic resonance imaging (MRI). Rats were subjected to middle cerebral artery (MCA) occlusion/reperfusion surgery. Melatonin was administered twice (6.0 mg/kg, p.o.) just prior to 1 hr of MCA occlusion and 1 day after the surgery. T2-weighted multislice spin-echo images were acquired 1 day after the surgery. In the saline-treated control rats, increases in T2-weighted signals (water content) were clearly observed in the striatum and in the cerebral cortex. In the melatonin-treated group, total volume of edema was reduced by 51.6% compared with control group (P < 0.01). The protective effect of melatonin against edema was more clearly observed in the cerebral cortex (reduced by 59.8%, P < 0.01) than in the striatum (reduced by 34.2%, P < 0.05). Edema volume in a coronal slice was the greatest at the level of the bregma. Suppression of cerebral edema by melatonin was more effective posterior than anterior to the bregma. Melatonin appeared to reduce the volume of the edematous sites rather than to shift the signal intensity distribution. The present MRI study clearly demonstrates the effectiveness of melatonin against cerebral edema formation in ischemic animals in vivo, especially in the cerebral cortex. Melatonin may be highly useful in preventing cortical dysfunctions such as motor, sensory, memory, and psychological impairments associated with ischemic stroke.
  • Takashi Kondoh; Hisayuki Uneyama; Hitoo Nishino; Kunio Torii
    Life Sciences 72 (4-5) 583 - 90 0024-3205 2002/12 [Refereed]
     
    Reduction of cerebral edema, an early symptom of ischemia, is one of the most important remedies for reducing subsequent chronic neural damage in stroke. Melatonin, a metabolite of tryptophan released from the pineal gland, has been found to be effective against neurotoxicity in vitro. The present study was aimed to demonstrate the effectiveness of melatonin in vivo in reducing ischemia-induced edema using magnetic resonance imaging (MRI). Rats were subjected to middle cerebral artery (MCA) occlusion/reperfusion surgery. Melatonin was administered twice (6.0 mg/kg, p.o.): just prior to 1 h MCA occlusion and 1 day after the surgery. T2-weighted multislice spin-echo images were acquired 1 day after the surgery. Increases in T2-weighted signals in ischemic sites of the brain were clearly observed after MCA occlusion. The signal increase was found mainly in the striatum and in the cerebral cortex in saline-treated control rats. In the melatonin-treated group, the total volume of cerebral edema was reduced by 45.3% compared to control group (P < 0.01). The protective effect of melatonin against cerebral edema was more clearly observed in the cerebral cortex (reduced by 56.1%, P < 0.01), while the reduction of edema volume in the striatum was weak (reduced by 23.0%). The present MRI study clearly demonstrated that melatonin is effective in reducing edema formation in ischemic animals in vivo, especially in the cerebral cortex. Melatonin may be highly useful in preventing cortical dysfunctions such as motor, sensory, memory, and psychological impairments.
  • Eiichi Tabuchi; Takashi Yokawa; Hrudananda Mallick; Toshiro Inubushi; Takashi Kondoh; Taketoshi Ono; Kunio Torii
    Brain Research 951 (2) 270 - 9 0006-8993 2002/10 [Refereed]
     
    Spatio-temporal dynamics of activated brain areas induced by drinking were investigated and visualized in behaving rats using functional magnetic resonance imaging (fMRI). The rats were trained to drink in the magnet bore, and the images were taken during and after drinking glucose and distilled water. During glucose ingestion, the signal intensity was increased continuously and maximally in the lateral hypothalamic area (LHA) and the ventromedial hypothalamus (VMH). Somewhat less intense activation in the central nucleus of the amygdala (AMc), and transient activation in the piriform cortex and the mediodorsal nucleus of the thalamus were observed. The signal intensities of other regions measured were largely unchanged. During post-ingestive periods, the signals re-increased in the hypothalamic areas and AMc. When water was given, LHA and VMH were similarly activated, however, the signal intensity in the amygdala was not significantly increased. The results indicate that these brain regions are activated differentially during drinking behavior, and that LHA and VMH play a central role in the control of not only feeding but also drinking. The regional activities in LHA and VMH are not principally related to the gustatory sensation, and the reactivation after drinking may be related to satisfaction or post-ingestive nutritional information. Also, the responses of AMc are probably due to reward value difference. To the best of our knowledge, this is the first report of mapping of brain areas using fMRI in behaving rats. The improved method described in this study for collecting fMRI data in behaving animals will be useful for studying functional network during animal behavior.
  • Miro Smriga; Makiko Kameishi; Tatsuro Tanaka; Takashi Kondoh; Kunio Torii
    Nutritional Neuroscience 5 (3) 189 - 99 1028-415X 2002/06 [Refereed]
     
    Rats were given free access to a running wheel, food, water, and a solution composed of branched-chain amino acids plus glutamine and arginine (the "BCAA-based" solution). A positive relationship between dark-period running distance and preference for the BCAA-based solution was observed. Serotonin release in the lateral hypothalamus, the central nucleus of amygdala and the medial nucleus raphe in overnight fluid-deprived rats during their first subsequent free drinking was also measured. A lowered serotonin release in the lateral hypothalamus characterized the rats that consumed the BCAA-based solution. No drink-related changes were observed in the amygdala. A separate group of rats was trained on a treadmill. Following the training period, plasma amino acids and brain serotonin release were measured during running. The BCAA-based solution infused before running elevated the branched chain amino acids/tryptophan plasma ratio at the end of, and after, running. Additionally, a decreased lateral hypothalamus serotonin release was seen 80 min after running, when compared with water-infused rats. No fluid-related changes in the amygdala were observed. The exercise-related shift in the fluid preference towards a BCAA-based solution suggests an ergogenic benefit. The forced-running study shows the lateral hypothalamus as a critical region in the effects of a BCAA-based solution.
  • Ryoi Tamura; Takashi Kondoh; Taketoshi Ono; Hisao Nishijo; Kunio Torii
    Journal of Neurophysiology American Physiological Society 84 (6) 2844 - 2858 0022-3077 2000/12 [Refereed]
     
    The present study investigated the effects of repeated cold stress on single neuron activity in the lateral hypothalamic area (LHA) and medial hypothalamic area (MHA) of behaving rats. The rats were trained to lick a protruding spout in response to one of several cue-tone stimuli (CTSs) to ingest water, or amino acid, NaCl or glucose solution. Following this training, the rats were raised under either stressed (repeated temperature changes between −3 and 24°C) or control (24°C) condition for 2 mo. During this period, neuronal activity was recorded in the LHA and MHA. For rats raised under the stressed condition, mean spontaneous firing rate of LHA neurons was significantly greater than for rats under the control condition. More LHA neurons in the stressed rats responded, with an accompanying decrease in activity (inhibitory response), to CTSs than in the control rats. During extinction learning, some LHA neurons enhanced or reversed the responses to CTSs in the stressed rats, whereas no LHA neurons showed such response changes in the control rats. In contrast to the effects of the stressed condition on LHA neuron activity, mean spontaneous firing rate of MHA neurons in the stressed rats was significantly smaller than in the control rats. Fewer MHA neurons in the stressed rats responded to CTSs and/or ingestion of sapid solutions. The preceding results suggested that repeated cold stress produces a specific pattern of changes in spontaneous activity and responses to sensory stimuli in LHA and MHA neurons; this could underlie the behavioral changes induced by repeated cold stress such as hyperphagia and hyper-reactivity to sensory stimuli.
  • Takashi Kondoh; Masato Mori; Taketoshi Ono; Kunio Torii
    The Journal of Nutrition Oxford University Press (OUP) 130 (4) 966S - 970S 0022-3166 2000/04 [Refereed][Invited]
  • Hisao Nishijo; Taketoshi Ono; Teruko Uwano; Takashi Kondoh; Kunio Torii
    The Journal of Nutrition Oxford University Press (OUP) 130 (4) 954S - 959S 0022-3166 2000/04 [Refereed][Invited]
  • Ryuichi Gejo; Yoshiharu Kawaguchi; Takashi Kondoh; Eiichi Tabuchi; Hisao Matsui; Kunio Torii; Taketoshi Ono; Tomoatsu Kimura
    Spine Ovid Technologies (Wolters Kluwer Health) 25 (8) 941 - 946 0362-2436 2000/04 [Refereed]
  • Hirofumi Hagino; Eiichi Tabuchi; Masayoshi Kurachi; Osamu Saitoh; Yueji Sun; Takashi Kondoh; Taketoshi Ono; Kunio Torii
    Brain Research Elsevier BV 813 (2) 367 - 373 0006-8993 1998/12 [Refereed]
  • Kunio Torii; Takashi Kondoh; Masato Mori; Taketoshi Ono
    Annals of the New York Academy of Sciences Wiley 855 (1 OLFACTION AND) 417 - 425 0077-8923 1998/11 [Refereed][Invited]
  • Eiichi Tabuchi; Teruko Uwano; Takashi Kondoh; Taketoshi Ono; Kunio Torii
    Brain Research Elsevier BV 739 (1-2) 139 - 155 0006-8993 1996/11 [Refereed]
  • Takashi Kondoh; Hisao Nishijo; Yusaku Takamura; Chiemi Kawanishi; Kunio Torii
    Behavioral Neuroscience American Psychological Association (APA) 110 (5) 1187 - 1192 0735-7044 1996/10 [Refereed]
  • Kunio Torii; Takashi Yokawa; Eiichi Tabuchi; Richard L. Hawkins; Masato Mori; Takashi Kondoh; Taketoshi Ono
    Amino Acids Springer Science and Business Media LLC 10 (1) 73 - 81 0939-4451 1996/03 [Refereed][Invited]
  • Lateral hypothalamic neuron response to application of amino acids in different nutritive conditions
    Eiichi Tabuchi; Takashi Kondoh; Tentcho Voynikov; Takashi Yokawa; Taketoshi Ono; Kunio Torii
    Olfaction and Taste XI Springer-Verlag 536 - 536 1994
  • Takashi Kondoh; Tentcho Voynikov; Eiichi Tabuchi; Takashi Yokawa; Taketoshi Ono; Kunio Torii
    Olfaction and Taste XI Springer-Verlag 534 - 535 1994
  • Central function in preference for amino acids
    Taketoshi Ono; Kunio Torii; Eiichi Tabuchi; Takashi Kondoh; Teruko Uwano
    Olfaction and Taste XI Springer-Verlag 372 - 375 1994
  • nACh receptor-activity modulating intracellular Ca2+ (RAMIC); its finding, properties and roles
    Ikuko Kimura; Hiroshi Tsuneki; Takashi Kondoh; Masayasu Kimura
    Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle Plenum Press 319 - 321 1992
  • Ikuko Kimura; Takashi Kondoh; Hiroshi Tsuneki; Masayasu Kimura
    Neuroscience Letters Elsevier BV 127 (1) 28 - 30 0304-3940 1991/06 [Refereed]
  • Enhancing effects of nicotinic acetylcholine receptor channel blockers on the neuromuscular blocking action of succinylcholine and its diabetic modification in streptozotocin-mice
    Ikuko Kimura; Hiroshi Tsuneki; Takashi Kondoh; Hiroshi Nojima; Masayasu Kimura
    Lessons from Animal Diabetes. The Tokyo Workshop Smith-Gordon 61 - 66 1991
  • Noncontractile acetylcholine receptor-operated Ca++ mobilization: suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle.
    Masayasu Kimura; Ikuko Kimura; Takashi Kondoh; Hiroshi Tsuneki
    Journal of Pharmacology and Experimental Therapeutics 256 (1) 18 - 23 1991/01 [Refereed]
  • Enhancing effect by nicotinic acetylcholine receptor channel blockers, including beta-eudesmol, on succinylcholine-induced inhibition of twitch tension and intracellular Ca++ in mouse diaphragm muscle
    Ikuko Kimura; Hiroshi Tsuneki; Takashi Kondoh; Masayasu Kimura
    Journal of Pharmacology and Experimental Therapeutics 256 (1) 24 - 28 1991/01 [Refereed]
  • Ikuko Kimira; Takashi Kondoh; Masayasu Kimura
    Journal of Pharmacy and Pharmacology Wiley 42 (9) 626 - 631 0022-3573 1990/09 [Refereed]
  • Ikuko Kimura; Takashi Kondoh; Masayasu Kimura
    Brain Research Elsevier BV 507 (2) 309 - 311 0006-8993 1990/01 [Refereed]
  • Ikuko Kimura; Takashi Kondoh; Masayasu Kimura
    British Journal of Pharmacology Wiley 96 (3) 739 - 745 0007-1188 1989/03 [Refereed]
  • Takashi Kondoh; Ikuko Kimura; Masayasu Kimura
    The Japanese Journal of Pharmacology Japanese Pharmacological Society 48 (2) 294 - 298 0021-5198 1988/10 [Refereed]
  • Ikuko Kimura; Takashi Kondoh; Masayasu Kimura
    European Journal of Pharmacology Elsevier BV 134 (2) 181 - 187 0014-2999 1987/02 [Refereed]
  • Masayasu Kimura; Ikuko Kimura; Takashi Kondoh; Masaaki Kimura
    European Journal of Pharmacology Elsevier BV 132 (2-3) 245 - 251 0014-2999 1986/12 [Refereed]

Books etc

  • 情動と食 : 適切な食育のあり方(小野武年・監修、二宮くみ子&谷和樹・編集)
    近藤高史 (Contributor第11章 だしの健康機能解明に向けて)朝倉書店 2017/02 9784254106978 243p 199-218
  • 近藤高史 (Contributor第10章 うま味研究の現状)朝倉書店 2017/02 9784254106978 243p 162-198
  • 近藤高史 (Contributor第II編 第1章 かつおだし)シーエムシー出版 2016/05 9784781311579 277p 31-40
  • Handbook of Behavior, Food and Nutrition (eds by Victor R. Preedy, Ronald R. Watson, and Colin R. Martin)
    Takashi Kondoh; Kunio Torii (ContributorChapter 154, Brain mechanisms involved in the detection and adaptation to lysine deficiency.)Springer Science + Business Media 2011/05 3527p 2451-2468
  • Handbook of Behavior, Food and Nutrition (eds by Victor R. Preedy, Ronald R. Watson, and Colin R. Martin)
    Takashi Kondoh; Kunio Torii (ContributorChapter 31, Forebrain activation by postoral nutritive substances.)Springer Science + Business Media 2011/05 3527 469-487
  • Body Fat: Composition, Measurements, and Reduction Procedures (ed. by Julie Bienertova-Vasku)
    Takashi Kondoh; Kunio Torii (ContributorChapter 4, MSG intake suppresses caloric intake, weight gain, and fat deposition in female Sprague-Dawley rats.)Nova Science publishers 2011/03 174p 79-96
  • 近藤高史; 鳥居邦夫 (Contributor食物摂取の認知と適応)サイエンスフォーラム 2008/10 9784916164926 325p, 図版[2]p 197-204
  • 近藤高史; 鳥居邦夫 (Contributor3章 味覚の神経回路と情報処理 3-2 情報処理)中山書店 2000/01 4521590314 502p 409-421
  • Kunio Torii; Takashi Yokawa; Eiichi Tabuchi; Takuya Murata, Richard; L. Hawkins; Masato Mori; Takashi Kondoh; Misako Takezawa; Taketoshi Ono (ContributorCentral Mechanisms of learned preference for a deficient nutrient and recognition of its intake in rats: deficiency of an essential L-amino acid, L-lysine.)Pergamon,Elsevier Science Japan 1996/10 0080427359 620 p. 467-478
  • 木村郁子; 恒枝宏史; 近藤高史; 木村正康 (Contributor骨格筋アセチルコリン受容体活性を制御する細胞内Ca2+ (RAMIC) とStreptozotocin糖尿病態による脱感作亢進)医薬ジャーナル社 1987/09 109-112

Conference Activities & Talks

  • Takashi KONDOH; Yui KATSUMATA; Kyoka YOSHITAKE
    日本農芸化学会2024年度大会(創立100周年記念大会)  2024/03  東京  日本農芸化学会
  • Enhancement of umami taste by adding various salts  [Not invited]
    Kana TANAKA; Haruka KATSURAGAWA; Takashi KONDOH
    日本農芸化学会2024年度大会(創立100周年記念大会)  2024/03  東京  日本農芸化学会
  • 市販飲料との組合せによる餅の苦味発生メカニズム  [Not invited]
    近藤高史; 天野莉奈; 武藤悠作
    食欲・食嗜好を形成する感覚・内分泌・神経基盤研究会  2023/12  岡崎
  • NaClのうま味増強作用  [Not invited]
    田中伽奈; 桂川晴花; 近藤高史
    食欲・食嗜好を形成する感覚・内分泌・神経基盤研究会  2023/12  岡崎
  • Takashi Kondoh; Yui Katsumata; Kyoka Yoshitake
    The 20th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2023)  2023/11  Okayama
  • Enhancement of umami taste by Na ion in humans  [Not invited]
    Kana Tanaka; Haruka Katsuragawa; Takashi Kondoh
    The 20th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2023)  2023/11  Okayama
  • Turning of umami research: shift from defense (safety) to offense (physiological significance)  [Not invited]
    Takashi Kondoh
    The 20th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2023)  2023/11  Okayama
  • だしと情動:食を通した支援の可能性  [Invited]
    近藤 高史; 堀悦郎; 西丸広史; 西条寿夫
    第12回日本情動学会大会、一般公開シンポジウム2「不登校の情動的支援」  2023/11  京都  日本情動学会
  • Taste modulation of rice cake by seasoning of commercial beverages in the mouth  [Not invited]
    近藤高史; 天野莉那; 武藤悠作
    日本味と匂学会第57回大会  2023/09  東京
  • Enhancement of umami taste by adding NaCl  [Not invited]
    田中伽奈; 桂川晴花; 近藤高史
    日本味と匂学会第57回大会  2023/09  東京
  • 各種塩添加によるうま味増加作用  [Not invited]
    田中伽奈; 桂川晴花; 近藤高史
    日本食品科学工学会第70回記念大会  2023/08  京都
  • うま味に対する塩の増加作用  [Not invited]
    田中伽奈; 桂川晴花; 近藤高史
    日本農芸化学会関西支部第525回講演会  2023/05  京都
  • Inosine 5’-monophosphate (IMP) enhances preference for dried bonito dashi by prior exposure in mice.  [Not invited]
    Takashi Kondoh
    The 19th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP2022/23)  2023/03  Okayama
  • だしのおいしさの秘密
    近藤 高史
    集まれアグリ村  2022/10  近畿大学農学部
  • かつおだし嗜好性増加に寄与する成分の探索  [Not invited]
    近藤 高史
    食欲・食嗜好を形成する感覚・内分泌・神経基盤研究会  2022/10
  • 発育期の出汁摂取と情動の発達  [Not invited]
    西丸広史; ndarmaa Jargalsaikhan; 近藤高史; 小野武年; 西条寿夫
    第10回日本情動学会 シンポジウム2「食と情動」  2021/12  名古屋  日本情動学会
     
    近年ますます複雑化する社会のなかで、子供の心の健康の発達と維持の重要性が改めて重要視されている。そのなかで心の健康を増進する上での日々の食の重要性、特に伝統的な食材の価値が見直されている。我々は最近、マウスを実験モデル動物として用いた行動科学的・組織形態学的アプローチによる研究によって、日本の代表的な伝統食の一つ、かつおだしの成長・発達期における摂取が、その後の情動行動の発達に大きな影響を与えることを示した。今回の発表では、情動に関連した脳領域において、その異常が統合失調症をはじめとする様々な精神疾患の病態と深く関わっていると考えられているパルブアルブミン陽性ニューロンの成熟と情動発達に対するかつおだし摂取の効果を紹介する。
  • 1. 化学感覚と食ー味嗅覚の生理ー、2. だし・うま味の研究  [Invited]
    近藤高史
    名古屋市立大学医学部医学科 生理学特別講義  2021/10  名古屋  名古屋市立大学医学部医学科
  • 複雑系(食品)の科学~かつおだしを例にして~  [Invited]
    近藤 高史
    第41回日本食品・機会研究会 令和3年度年次大会  2021/06  京都  日本食品・機会研究会
  • だし・うま味の健康機能  [Invited]
    近藤高史
    第34回「食と医のセミナー」(オンデマンド開催)  2020/11  広島  公益社団法人広島県栄養士会・味の素株式会社中四国支店
  • かつおだし嗜好性における砂糖およびたんぱく質摂取の影響  [Not invited]
    近藤 高史
    日本味と匂学会第54回大会(オンライン開催)  2020/10
  • 食と健康との関わり  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義(オンデマンド)  2020/09  八王子  工学院大学大学院工学研究科
  • 化学感覚と食-味嗅覚の生理-  [Invited]
    近藤高史
    名古屋市立大学医学部医学科 生理学特別講義  2020/09  名古屋  名古屋市立大学医学部医学科
  • だし・うま味の健康機能~いまさら聞けないうま味の新常識を中心に~  [Invited]
    近藤高史
    2019年度「食と健康セミナー」  2020/02  名古屋  味の素株式会社&愛知県栄養士会
  • 心を育む”かつおだし”の力  [Invited]
    近藤高史
    和食の日「食育ネットワーク講演会・試食会」  2019/11  青森  青森県民生活協同組合&青森県食生活改善推進員連絡協議会
  • だしのおいしさと健康機能  [Invited]
    近藤高史
    兵庫県阪神シニアカレッジ 共通講座講義  2019/06  宝塚  兵庫県阪神シニアカレッジ
  • 食と健康との関わり  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義  2019/05  八王子  工学院大学大学院工学研究科
  • TMC6: a novel salt taste receptor in mice.  [Not invited]
    Takami Maekawa; Koki Kamiya; Tooru Takahashi; Kentaro Kaji; Yukio Tezuka; Toshihisa Osaki; Shoji Takeuchi; Takashi Kondoh
    The 41th Association for Chemoreception Sciences (AChemS 2019)  2019/04  Bonita Springs
  • 和食を支えるだしの魅力~おいしさ、健康、そして食育へ~  [Invited]
    近藤高史
    市民公開シンポジウム「お酒と食の文化と科学~生活を彩る豊かな食の形を求めて~」  2019/03  京都  京都府立大学生命環境科学研究科
  • 心身を育むかつおだしの力  [Invited]
    近藤高史
    健康ヘルシーUPセミナー  2019/03  おいらせ  青森県民生活協同組合&味の素株式会社
  • 食の未来への貢献:心身を育むかつおだしの力 ~和食給食を通して和食好きな子供を育てる~  [Invited]
    近藤高史
    和食給食研究会講演  2018/12  東京  和食給食研究会
  • 心身を育むかつおだしの力  [Invited]
    近藤高史
    健康ヘルシーUPセミナー  2018/11  青森  青森県民生活協同組合&味の素株式会社
  • 化学感覚と食-味嗅覚の生理-  [Invited]
    近藤高史
    名古屋市立大学医学部医学科 生理学特別講義  2018/07  名古屋  名古屋市立大学医学部医学科
  • だしのおいしさと健康機能  [Invited]
    近藤高史
    兵庫県阪神シニアカレッジ 共通講座講義  2018/06  宝塚  兵庫県阪神シニアカレッジ
  • 食と健康との関わり~だしの嗜好性と生理機能~  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義  2018/05  八王子  工学院大学大学院工学研究科
  • かつおだし健康価値と減塩  [Invited]
    近藤高史
    青森食育ネットワーク講演会  2018/03  青森  青森食育ネットワーク
  • 和食を支えるかつおだしの健康価値  [Invited]
    近藤高史
    健康ヘルシーUPセミナー  2017/11  青森
  • かつおだしの健康価値  [Invited]
    近藤高史
    会津若松「健康食&おだしカフェ」  2017/07  会津若松
  • かつおだしの持つ幅広い機能  [Invited]
    近藤高史
    第103回醸造調味食品セミナー  2017/07  東京  日本醸造協会
  • かつおだしの健康価値  [Invited]
    近藤高史
    「食のみやぎ復興ネットワーク」勉強会  2017/06  亘理  みやぎ生協亘理店
  • だしのおいしさと健康機能  [Invited]
    近藤高史
    兵庫県阪神シニアカレッジ 共通講座講義  2017/06  宝塚  兵庫県阪神シニアカレッジ
  • 和食を支えるだしの嗜好性と健康機能  [Invited]
    近藤高史
    大阪市立大学大学院医学研究科「運動生体医学研究会」講演  2017/06  大阪  大阪市立大学大学院医学研究科「運動生体医学研究会」
  • 化学感覚と食-味嗅覚の生理-  [Invited]
    近藤高史
    久留米大学医学部生理学特別講義  2017/06  久留米  久留米大学医学部生理学
  • 近藤 高史
    フード・フォラム・つくば 春の例会  2017/05  つくば
  • かつおだしの嗜好性と機能性  [Invited]
    近藤高史
    シーエムシー出版FORUM セミナー「日本食における“だし”のうま味成分と健康機能」  2017/05  東京  シーエムシー出版
  • 食と健康との関わり~だしの嗜好性と生理機能~  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義  2017/05  八王子  工学院大学大学院工学研究科
  • かつおだし摂取がマウスの情動行動に及ぼす効果とその神経メカニズム  [Invited]
    西丸広史; ndarmaa Jargalsaikhan; 松本淳平; 高村雄策; 中村友也; 堀悦郎; 近藤高史; 小野武年; 西条寿夫
    第94回日本生理学会大会 シンポジウム「情動行動における口腔・腸—脳連関の重要性」  2017/03  浜松  日本生理学会
  • 和食を支えるだしの秘密に迫る~おいしさ、健康、そして食育へ~  [Invited]
    近藤高史
    日本農芸化学会2017年度大会 シンポジウム「伝統的発酵食品の生理機能の新展開」  2017/03  京都  日本農芸化学会
  • 和食を支えるかつおだしの健康価値  [Invited]
    近藤高史
    青森食育ネットワーク講習会  2017/03  青森  青森食育ネットワーク
  • 和食を支えるだしの健康機能~消化管から脳まで~  [Invited]
    近藤高史
    日本大学生物資源科学部 平成28年度公開シンポジウム“食機能としての「食欲」を考える”  2016/12  藤沢  日本大学生物資源科学部
  • 食と健康との関わり~だしの嗜好性と生理機能~  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義  2016/12  八王子  工学院大学大学院工学研究科
  • 知られざるかつおだしの秘密~うま味のほかにも意外な効能あり?~  [Invited]
    近藤高史
    東日本国際大学講演会  2016/11  いわき
  • 知られざるかつおだしの秘密~うま味のほかにも意外な効能あり?~  [Invited]
    近藤高史
    日本ギフト大賞W受賞記念講演会~和食の日(11月24日)を考える~  2016/11  会津若松
  • 食と健康との関わり~かつおだしを例にして  [Invited]
    近藤高史
    名古屋市立大学医学部医学科 生理学講義  2016/07  名古屋  名古屋市立大学医学部医学科
  • かつおだし嗜好性に関与する3つの主要因子  [Not invited]
    近藤高史
    第1回食欲・食嗜好の分子・神経基盤研究会  2016/06  岡崎
  • だしのおいしさと健康機能  [Invited]
    近藤高史
    兵庫県阪神シニアカレッジ 共通講座講義  2016/06  宝塚  兵庫県阪神シニアカレッジ
  • 食と健康~だしの嗜好と健康機能~  [Invited]
    近藤高史
    下神白災害公営住宅および薄磯災害公営住宅 講演会  2016/06  いわき
  • Effects of dried-bonito broth on development of parvalbumin-immunoreactive neurons in the brain and emotional behaviors in mice.  [Not invited]
    Undarmaa Jargalsaikhan; Jumpei Matsumoto; Yusaku Takamura; Tomoya Nakamura; Etsuro Hori; Hiroshi Nishimaru; Takashi Kondoh; Taketoshi Ono; Hisao Nishijo
    The 17th International Symposium on Olfaction and Taste (ISOT2016)  2016/06  Yokohama
  • 食と健康との関わり~だしの嗜好と健康機能~  [Invited]
    近藤高史
    相馬ガス株式会社食育活動開始記念講演会  2016/04  南相馬  相馬ガス株式会社
  • 食と健康との関わり~だしの嗜好と健康機能~  [Invited]
    近藤高史
    (株)キクチ講演会  2016/03  相馬  (株)キクチ
  • 和食を支えるだしの魅力  [Invited]
    近藤高史
    青森市食生活改善推進員会講演会  2016/03  青森  青森市食生活改善推進員会
  • うま味のサイエンス  [Invited]
    近藤高史
    第19回日本病態栄養学会年次学術集会 シンポジウム10「味のサイエンス」  2016/01  横浜  日本病態栄養学会
  • 食と健康との関わり  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義  2015/12  八王子  工学院大学大学院工学研究科
  • Food intake on health - cutting-edge science of dashi -  [Invited]
    近藤高史
    名古屋大学大学院医学系研究科「ニューロサイエンスコース」講義  2015/12  名古屋  名古屋大学大学院医学系研究科
  • 知られざるかつおだしのひみつ
    近藤高史
    会津若松市食育ネットワーク研究会  2015/12  会津若松  会津若松市食育ネットワーク研究会
  • かつおだし摂取がマウス情動行動およびパルブアルブミン(PV)陽性ニューロンに及ぼす効果  [Not invited]
    堀悦郎; Undarmaa Jargalsaikhan; 松本淳平; 高村雄策; 中村友也; 近藤高史; 小野武年; 西条寿夫
    第5回日本情動学会  2015/11  東京
  • だし研究の最先端~おいしさと健康への寄与~  [Invited]
    近藤高史
    日本生活協同組合連合会 食品勉強会  2015/11  戸田  日本生活協同組合連合会
  • 迷走神経切除はラット扁桃体および視床下部外側野ニューロンのうま味溶液の胃内注入に対する応答を変化させる  [Not invited]
    Munkhzul Davaasuren; 松本淳平; Choijiljav Chinzorig; 中村友也; 西丸広史; 高村雄策; Enrico Patrono; 近藤高史; 小野武年; 西条寿夫
    第62回中部日本生理学会  2015/11  富山  (一社)日本生理学会
  • かつおだし摂取はパルブアルブミン(PV)陽性ニューロン数を増大させマウス情動行動を変化させる  [Not invited]
    Undarmaa J.; 松本 惇平; 高村 雄策; 西丸 弘史; 中村 友也; 堀 悦郎; 近藤 高史; 小野 武年; 西条 寿夫
    第62回中部日本生理学会  2015/11  富山  (一社)日本生理学会
  • 和食を支えるだしの魅力と食育への展望  [Invited]
    近藤高史
    第9回つくば市食育講演会  2015/10  つくば  つくば市役所
  • Takashi Kondoh
    第67回日本生物工学会大会 産学官連携シンポジウム「食品のおいしさを極める生物工学」  2015/10  鹿児島  日本生物工学会
  • だしのサイエンスとポテンシャル  [Invited]
    近藤高史
    第25回日本清涼飲料研究会 総会・研究発表会 特別講演2  2015/10  東京  日本清涼飲料研究会
  • Stimulus generalization of conditioned taste aversion of dashi to salts is modified by lactic acid in mice.  [Not invited]
    Eugene R. Delay; Ben Weaver; Doug Lane; Takashi Kondoh
    Society for Neuroscience 2015  2015/10  Chicago
  • Health-related functions of dried bonito dashi (a traditional Japanese fish stock).  [Invited]
    Takashi Kondoh; Tetsuro Matsunaga; Yoichi Ueta; Hisao Nishijo
    The 5th Central European Congress on Obesity (CECON), Symposium "Central regulation of energy balance, hunger and satiety"  2015/10  Budapest  Central European Congress on Obesity (CECON)
  • うま味溶液の胃内注入がラット扁桃体および視床下部外側野ニューロン活動に及ぼす作用  [Not invited]
    Munkhzul Davaasuren; 松本淳平; Choijiljav Chinzorig; 中村友也; 高村雄策; Enrico Patrono; 近藤高史; 小野武年; 西条寿夫
    日本味と匂学会第49回大会  2015/09  岐阜
  • かつおだし摂取がマウス情動行動およびパルブアルブミン(PV)陽性ニューロンに及ぼす効果  [Not invited]
    Undarmaa Jargalsaikhan; 松本淳平; 高村雄策; 中村友也; 堀悦郎; 近藤高史; 小野武年; 西条寿夫
    日本味と匂学会第49回大会  2015/09  岐阜
  • Preference and functions of dried bonito dashi (a traditional Japanese fish stock).  [Invited]
    Takashi Kondoh
    Recent developments in the study of feeding and metabolic control mechanisms, Pécs University Medical School  2015/09  Pécs  Pécs University Medical School
  • 和食を支えるだしの魅力  [Invited]
    近藤高史
    科学技術館・科学ライブショー「ユニバース」  2015/08  東京  科学技術館
  • 「知られざるかつおだしの秘密」~うま味のほかにも意外な効能あり?~  [Invited]
    近藤高史
    愛知学院大学 第111回モーニング・セミナー  2015/06  名古屋  愛知学院大学
  • だしのおいしさと健康機能  [Invited]
    近藤高史
    兵庫県阪神シニアカレッジ講義  2015/06  宝塚  兵庫県阪神シニアカレッジ
  • 和食を支えるだしのおいしさと健康への寄与  [Invited]
    近藤高史
    茨城県立健康プラザ研修会(食と健康スペシャル講座)  2015/02  水戸  水戸市役所
  • 近藤 高史
    第18回日本病態栄養学会年次学術集会 シンポジウム「和食を科学する」  2015/01  京都  (一社)日本病態栄養学会
  • 食と健康との関わり  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義  2014/12  八王子  工学院大学大学院工学研究科
  • だし研究の最先端~おいしさと健康への寄与~  [Invited]
    近藤高史
    富山大学特別講演会  2014/12  富山  富山大学薬学部
  • 和食の健康価値の科学的エビデンス(2):かつおだし摂取は攻撃行動とうつを抑制する  [Not invited]
    近藤高史; ndarmaa Jargalsaikhan; 中村友也; 松本惇平; 堀悦郎; 小野武年; 西条寿夫
    第4回日本情動学会  2014/11  名古屋
  • 和食の健康価値の科学的エビデンス(1):かつおだし摂取は不安を抑制する  [Not invited]
    近藤高史; 船津祥一郎; 川瀬貴博; 池田裕美; 長澤麻央; Michael D. Denbow; 古瀬充宏
    第4回日本情動学会  2014/11  名古屋
  • かつおだしおよびうま味嗜好性にドーパミン神経系は関与しない  [Not invited]
    Amartuvshin Bor; 中村友也; 吉村充弘; 上田陽一; 上野照子; 近藤高史; 小野武年; 西条寿夫
    日本味と匂学会第48回大会  2014/10  静岡
  • ここまでわかった、かつおだしの健康価値  [Invited]
    近藤高史
    第61会日本栄養改善学会学術総会 シンポジウム“和食のエッセンス『だし・うま味』の健康価値を考える”  2014/08  横浜  日本栄養改善学会
  • 食の未来への貢献~だしのおいしさと健康効果~  [Invited]
    近藤高史
    学校給食勉強会~和食におけるだしの役割  2014/07  東京  丸幸水産株式会社
  • かつおだしはなぜ美味しいのか~味と機能の探求  [Invited]
    近藤高史
    JBAバイオセミナーシリーズ、“未来へのバイオ技術”勉強会「美味しさとは何か」  2014/06  東京  ジャパンバイオインダストリー
  • Takashi Kondoh
    The Japanese Journal of Taste and Smell Research  2014/06  東京  うま味研究会
     
    和食の基本は「だし」である。だしの代表格であるかつおだしを用いて嗜好性の調節機構を調べた結果、少なくとも3つの因子(遺伝因子、高脂肪食摂取、かつおだしの摂取体験/学習)が関与することが明らになった。とくに、だしの摂取体験がだしの嗜好性増加に大きく影響したことから、味や香りや食感以外の因子が強く関与することが示唆された。だしは嗜好濃度が低いため、カロリー摂取はほとんど期待できない。従って、だしの摂取によって何らかの生理的変化(健康機能)が生じることが予想された。本稿では、かつおだしの嗜好性を決める因子とかつおだしの健康機能について解説する。
  • 食と健康との関わり~かつおだしを例にして  [Invited]
    近藤高史
    名古屋市立大学医学部医学科 生理学特別講義  2014/06  名古屋  名古屋市立大学医学部医学科
  • だしのおいしさと健康機能  [Invited]
    近藤高史
    兵庫県阪神シニアカレッジ 共通講座講義  2014/06  宝塚  兵庫県阪神シニアカレッジ
  • 和食を支えるだしの魅力  [Invited]
    近藤高史
    工学院大学オープンカレッジ講義  2014/04  東京  工学院大学
  • 和食を支えるだしの魅力に迫る!  [Invited]
    近藤高史
    科学技術館・科学ライブショー「ユニバース」  2014/02  東京  科学技術館
  • 和食におけるだしの魅力~おいしさと健康機能の二重奏~  [Invited]
    近藤高史
    JEOL食品分析ソリューションセミナー  2014/01  東京  株式会社JEOL RESONANCE
  • 和食を支えるだしの魅力~おいしさと健康機能~  [Invited]
    近藤高史
    フードバレーとかち推進協議会および公益財団法人・とかち財団主催講演会 「とかち」らしいフードスタイルを求めて  2014/01  十勝  フードバレーとかち推進協議会、公益財団法人・とかち財団
  • 「だしのおいしさと健康機能」~和食の魅力と医用分光学への期待~  [Invited]
    近藤高史
    第11回医用分光学研究会  2013/12  福井  医用分光学研究会
  • 奈良朝における「うま味調味料:楡皮」のNMR研究  [Not invited]
    鈴木榮一郎; 伊藤萌美; 小澤真一; 水越利巳; 近藤高史; 宮野博
    第52回NMR討論会  2013/11  金沢
  • だしのサイエンスとそのポテンシャル  [Invited]
    近藤高史
    2013年度工学院大学創立記念日シンポジウム  2013/10  東京  工学院大学
  • Undarmaa J.; 堀 悦郎; 松本 淳平; 近藤 高史; 小野 武年; 西条 寿夫
    第60 回中部日本生理学会  2013/10  岐阜  (一社)日本生理学会
  • かつおだしの嗜好性と健康への貢献  [Invited]
    近藤高史
    工学院大学大学院工学研究科「化学応用学特論A」講義  2013/10  八王子  工学院大学大学院工学研究科
  • だしのおいしさと生理機能  [Invited]
    近藤高史
    名古屋市立大学医学部医学科 生理学特別講義  2013/07  名古屋  名古屋市立大学医学部医学科
  • かつおだしの秘密に迫る~おいしさと健康機能の二重奏~  [Invited]
    近藤高史
    第8回食育推進全国大会 ミニシンポジウム「おいしさの科学」  2013/06  広島
  • Dried-bonito dashi: Taste qualities evaluated using CTA methods in wild type and T1R1 KO mice.  [Not invited]
    Eugene R. Delay; Takashi Kondoh
    The 35th Association for Chemoreception Sciences (AChemS 2013)  2013/04  Huntington Beach
  • カツオだしの健康機能  [Invited]
    近藤高史
    第17回「食」と「漁」を考える地域シンポジウム「カツオ・鰹節の食と文化」  2013/04  東京
  • かつおだしの嗜好性のメカニズム  [Invited]
    近藤高史
    日本農芸化学会2013年度大会 味の素株式会社主催ランチョンセミナー「だしのおいしさの秘密と健康への寄与」  2013/03  仙台  日本農芸化学会
  • 食の未来への貢献~かつおだしのおいしさと健康効果~  [Invited]
    近藤高史
    滋賀県栄養士会医療栄養士協議会研修会  2013/03  近江八幡  滋賀県栄養士会医療栄養士協議会
  • 情動行動に及ぼすかつおだし摂取の影響  [Not invited]
    Undarmaa J.; 堀 悦郎; 近藤 高史; 小野 武年; 西条 寿夫
    第59 回中部日本生理学会  2012/11  岡崎  (一社)日本生理学会
  • だしのおいしさと健康への寄与  [Invited]
    近藤高史
    近畿土壌肥料研究協議会第33回総会・記念講演会  2012/11  大阪  近畿土壌肥料研究協議会
  • だしのおいしさと健康機能  [Invited]
    近藤高史
    第33回日本肥満学会市民公開講座「日本食と肥満症:美味しく健康に暮らすために」  2012/10  京都  日本肥満学会
  • マウスの情動行動に対するかつおだし液摂取の効果  [Not invited]
    Jargalsaikhan Undarmaa; 堀 悦郎; 近藤高史; 小野武年; 西条寿夫
    日本味と匂学会第46回大会  2012/10  大阪
  • かつおだし摂取の食後の胃排出と空腹感・満腹感に対する効果  [Not invited]
    松永哲郎; 津田謹輔; 近藤高史
    第59回日本栄養改善学会  2012/09  名古屋
  • かつおだし嗜好性を増加させる因子:離乳直後摂取経験の検討  [Not invited]
    近藤高史; 松永哲郎; 津田謹輔
    第59回日本栄養改善学会  2012/09  名古屋
  • かつおだし摂取による情動/社会行動の改善  [Invited]
    堀悦郎; Jargalsaikhan Undarmaa; 近藤高史; 小野武年; 西条寿夫
    京都大学「食の未来戦略講座」主催シンポジウム「だしのおいしさと健康機能~ここまでわかったかつおだしの秘密~」  2012/08  京都  京都大学「食の未来戦略講座」
  • ヒトの胃機能および満腹感に対するかつおだし摂取の効果  [Invited]
    松永哲郎; 種村一識; 山崎英恵; 津田謹輔; 近藤高史
    京都大学「食の未来戦略講座」主催シンポジウム「だしのおいしさと健康機能~ここまでわかったかつおだしの秘密~」  2012/08  京都  京都大学「食の未来戦略講座」
  • かつおだし胃内投与後の脳活動上昇  [Invited]
    上田 陽一; 吉村充弘; 近藤高史
    京都大学「食の未来戦略講座」主催シンポジウム「だしのおいしさと健康機能~ここまでわかったかつおだしの秘密~」  2012/08  京都  京都大学「食の未来戦略講座」
  • Postingestive signals and dashi appetite.  [Invited]
    Luis A. Tellez; Takashi Kondoh; Ivan E. de Araujo
    京都大学「食の未来戦略講座」主催シンポジウム「だしのおいしさと健康機能~ここまでわかったかつおだしの秘密~」  2012/08  京都  京都大学「食の未来戦略講座」
  • Taste of dried-bonito dashi in mice as accessed by conditioned taste aversion.  [Invited]
    Eugene R. Delay; Takashi Kondoh
    京都大学「食の未来戦略講座」主催シンポジウム「だしのおいしさと健康機能~ここまでわかったかつおだしの秘密~」  2012/08  京都  京都大学「食の未来戦略講座」
  • サルにおけるかつおだし摂取体験と嗜好性変化  [Invited]
    西条 寿夫; Bretas Vieira Rafael; 堀 悦郎; Jargalsaikhan Undarmaa; 小野武年; 近藤 高史
    京都大学「食の未来戦略講座」主催シンポジウム「だしのおいしさと健康機能~ここまでわかったかつおだしの秘密~」  2012/08  京都  京都大学「食の未来戦略講座」
  • かつおだし嗜好性を決める3つの主要因子  [Invited]
    近藤高史
    京都大学「食の未来戦略講座」主催シンポジウム「だしのおいしさと健康機能~ここまでわかったかつおだしの秘密~」  2012/08  京都  京都大学「食の未来戦略講座」
  • かつおだしのおいしさの秘密 ~生理機能との二重奏~  [Invited]
    近藤高史
    第18回味の素KK「食と健康セミナー」  2012/08  東京  味の素(株)東京支社
  • Effects of dried-bonito dashi (a traditional Japanese fish stock) on gastric emptying, gastric myoelectrical activity and hunger-satiety ratings in humans.  [Not invited]
    Tetsuro Matsunaga; Kazushi Tanemura; Hanae Yamazaki; Kinsuke Tsuda; Takashi Kondoh
    The 20th Annual Meeting of the Society for the Study of Ingestive Behavior (2012 SSIB)  2012/07  Zurich
  • Learned preference for dried-bonito dashi (a traditional Japanese fish stock) and its suppression by high fat diet.  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga; Ivan E. de Araujo
    The 20th Annual Meeting of the Society for the Study of Ingestive Behavior (2012 SSIB)  2012/07  Zurich
  • Effects of dried-bonito broth intake on autonomic nervous system activity and mood states in healthy volunteers.  [Not invited]
    Hanae Yamazaki; Mari Toshima; Tetsuro Matsunaga; Tohru Fushiki; Takashi Kondoh
    The 2012 Institute of Food Technologists (IFT) Annual Meeting & Food Expo  2012/06  Las Vegas
  • Enhancement of preference for dried-bonito dashi (a traditional Japanese fish stock) by prior food experience.  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga; Hanae Yamazaki; Taiho Kambe; Masaya Nagao
    The 16th International Symposium on Olfaction and Taste (ISOT 2012)  2012/06  Stockholm
  • Multiple effects of umami compounds in the forebrain.  [Invited]
    Hisao Nishijo; Jumpei Matsumoto; Davaasuren Munkhzul; Etsuro Hori; Teruko Uwano; Takashi Kondoh; Taketoshi Ono
    The 16th International Symposium on Olfaction and Taste (ISOT 2012), In Parallell Session Symposium 19: Preference for umami taste controlled by chemical senses - Ajinomoto Symposium.  2012/06  Stockholm  International Symposium on Olfaction and Taste (ISOT)
  • 男子大学生における食後の胃運動に関連する要因の検討  [Invited]
    松永哲郎; 足達哲也; 津田謹輔; 近藤高史
    第59 回近畿学校保健学会  2012/06  京都
  • だしのおいしさと生理機能  [Invited]
    近藤高史
    徳島大学医学部栄養学科 「栄養生理機能学」講義  2012/06  徳島  徳島大学医学部栄養学科
  • 食品研究はおもしろい ~だしの美味しさの秘密~  [Invited]
    近藤高史
    大塚食品株式会社徳島食品研究所  2012/06  徳島  大塚食品株式会社徳島食品研究所
  • だしのおいしさと生理機能  [Invited]
    近藤高史
    徳島大学大学院ヘルスバイオサイエンス研究部 大学院特別講義  2012/06  徳島  徳島大学大学院ヘルスバイオサイエンス研究部
  • かつおだしのおいしさの秘密 ~生理機能との二重奏~  [Invited]
    近藤高史
    九州大学大学院農学研究院 古瀬充宏研究室セミナー  2012/06  福岡  九州大学大学院農学研究院 古瀬充宏研究室
  • Tanemura Kazushi; Matsunaga Tetsuro; Yamazaki Hanae; Li Shiho; Joo Erina; Adachi Tetsuya; Kondoh Takashi; Tsuda Kinsuke
    第66回日本栄養・食糧学会大会  2012/05  仙台  Japan Society of Nutrition and Food Science
     
    コーヒーは胃運動と自律神経活動を亢進させることが示唆された。
  • 食後の胃排出と空腹感・満腹感に対するかつおだし摂取の効果  [Not invited]
    松永 哲郎; 種村 一識; 山崎 英恵; 津田 謹輔; 近藤 高史
    第66回日本栄養・食糧学会大会  2012/05  仙台  (公社)日本栄養・食糧学会
  • Gタンパク質β3サブユニットのC825T遺伝子多型と胃電気活動との関連解析  [Not invited]
    松永哲郎; 山崎英恵; 足達哲也; 安田浩一朗; 津田謹輔; 近藤高史
    第55回日本糖尿病学会年次学術集会  2012/05  横浜
  • 食品研究は面白い ~だしのおいしさの秘密~  [Invited]
    近藤高史
    日本調理食品研究会平成24年度年次大会  2012/05  大阪  日本調理食品研究会
  • Experience-based preference for dried-bonito dashi (a traditional Japanese fish stock).  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga
    The International Behavioral Neuroscience Society (IBNS) 21st Annual Meeting  2012/05  Kailua-Kona
  • 天然だしのおいしさを科学する~生理機能との二重奏~  [Invited]
    近藤高史
    京都大学大学院生命科学研究科統合生命科学専攻生体情報応答学分野 永尾雅哉研究室セミナー  2012/05  京都  京都大学大学院生命科学研究科統合生命科学専攻生体情報応答学分野 永尾雅哉研究室
  • Experience-based enhancement of preference for dried-bonito dashi (a traditional Japanese fish stock) in various rodent strains.  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga; Yoichi Ueta; Etsuro Hori; Hisao Nishijo
    The 34th Association for Chemoreception Sciences (AChemS 2012)  2012/04  Huntington Beach
  • かつおだし単回摂取のヒト胃運動および満腹感に対する効果  [Not invited]
    松永哲郎; 種村一識; 山崎英恵; 津田謹輔; 近藤高史
    日本農芸化学会2012年度大会  2012/03  京都
  • かつおだしの美味しさに関与する因子:脂肪・砂糖摂取と食経験/学習の関与  [Not invited]
    近藤高史; 松永哲郎; 椎名貴彦; 志水泰武
    日本農芸化学会2012年度大会  2012/03  京都
  • コーヒー摂取が胃運動機能および自律神経活動に与える効果の検討  [Not invited]
    種村一識; 松永哲郎; 山崎英恵; 李子帆; 城尾恵里奈; 足達哲也; 近藤高史; 津田謹輔
    第15回日本病態栄養学会年次学術集会  2012/01  京都
  • 若年日本人におけるGタンパク質β3サブユニットのC825T遺伝子多型と胃電気活動との関連解析  [Not invited]
    松永哲郎; 山崎英恵; 足達哲也; 津田謹輔; 近藤高史
    第15回日本病態栄養学会年次学術集会  2012/01  京都
  • うま味およびだしのおいしさと生理機能  [Invited]
    近藤高史
    サントリービジネスエキスパート講演会  2012/01  大阪  サントリービジネスエキスパート株式会社
  • Association of G-protein beta3 (GNB3) subunit C825T polymorphism with gastric myoelectrical activity in young healthy Japanese males.  [Not invited]
    松永哲郎; 山崎英恵; 足達哲也; 津田謹輔; 近藤高史
    第34回日本分子生物学会年会  2011/12  横浜
  • かつおだしのおいしさの秘密―だしは日本の食文化の誇り―  [Invited]
    近藤高史
    京都大学職員組合農学部支部セミナー  2011/11  京都  京都大学職員組合農学部支部
  • ここまでわかった、だしのおいしさの秘密!  [Invited]
    近藤高史
    第3回味の素KK「食と健康セミナー」  2011/11  名古屋  味の素(株)名古屋支社
  • Effects of coffee intake on gastric motility and autonomic nervous activity in young healthy volunteers.  [Not invited]
    Kazushi Tanemura; Tetsuro Matsunaga; Hanae Yamazaki; Li Shiho; Erina Joo; Tetsuya Adachi; Takashi Kondoh; Kinsuke Tsuda
    2011 Annual Meeting of the International Society for Nutraceuticals and Functional Foods (2011 ISNFF)  2011/11  Sapporo
  • Effects of dried-bonito dashi (a traditional Japanese fish stock) on gastric myoelectrical activity and satiety in young healthy volunteers.  [Not invited]
    Tetsuro Matsunaga; Kazushi Tanemura; Hanae Yamazaki; Kinsuke Tsuda; Takashi Kondoh
    2011 Annual Meeting of the International Society for Nutraceuticals and Functional Foods (2011 ISNFF)  2011/11  Sa
  • Learned preference for dried-bonito dashi (a traditional Japanese fish stock): a linkage with physiological function.  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga; Ivan E. de Araujo
    2011 Annual Meeting of the International Society for Nutraceuticals and Functional Foods (2011 ISNFF), In Session 24: Functional Foods Formulation-1  2011/11  Sapporo  International Society for Nutraceuticals and Functional Foods (ISNFF)
  • かつおだしのおいしさの秘密―だしは日本の食文化の誇り―  [Invited]
    近藤高史
    広島大学歯学部口腔生理学講義  2011/11  広島  広島大学歯学部口腔生理学
  • Induction of Fos expression in the rat forebrain after intragastric administration of monosodium L-glutamate.  [Invited]
    Yoichi Ueta; Takashi Kondoh; Kunio Torii
    The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP)  2011/11  Fukuoka
  • Behavioral significance of umami taste in the forebrain.  [Invited]
    Hisao Nishijo; Etsuro Hori; Teruko Uwano; Jumpei Matsumoto; Takashi Kondoh; Kunio Torii; Taketoshi Ono
    The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP)  2011/11  Fukuoka
  • Neuronal response of amygdala and lateral hypothalamic area to intragastric administration of amino acids.  [Not invited]
    Jumpei Matsumoto; Davaasuren Munkhzul; Etsuro Hori; Takashi Kondoh; Akihiko Kitamura; Hideki Matsumoto; Kunio Torii; Taketoshi Ono; Hisao Nishijo
    The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  2011/11  Fukuoka
  • だしのおいしさと生理機能  [Invited]
    近藤高史
    岐阜大学応用生物科学部獣医生理学 志水泰武研究室セミナー  2011/10  岐阜  岐阜大学応用生物科学部獣医生理学 志水泰武研究室
  • 招聘講演「ここまでわかった!だしのおいしさの秘密」  [Invited]
    近藤高史
    京都大学大学院農学研究科(宇治キャンパス)講義  2011/10  京都  京都大学大学院農学研究科(宇治キャンパス)
  • MATSUNAGA Tetsuro; TANEMURA Kazushi; YAMAZAKI Hanae; TSUDA Kinsuke; KONDOH Takashi
    日本味と匂学会第45回大会  2011/10  金沢  The Japanese Association for the Study of Taste and Smell
  • KONDOH Takashi; MATSUNAGA Tetsuro; NAKAMURA Kazuhiro; HORI Etsuro; NISHIJO Hisao
    日本味と匂学会第45回大会  2011/10  金沢  The Japanese Association for the Study of Taste and Smell
  • かつおだしはすごい!-生理機能にリンクしたおいしさの秘密-  [Invited]
    近藤高史
    ヤマキ株式会社講演会  2011/09  伊予  ヤマキ株式会社
  • 招聘講演「食品研究は面白い!-かつおだしを例にして-」  [Invited]
    近藤高史
    京都大学大学院農学研究科農学専攻品質評価学分野中間発表会(宇治キャンパス)  2011/09  京都  京都大学大学院農学研究科農学専攻品質評価学分野
  • 近藤 高史; 松永 哲郎; 上田 陽一; 志水 泰武; 西条 寿夫
    第32回日本肥満学会  2011/09  淡路  (一社)日本肥満学会
  • 松永 哲郎; 津田 謹輔; 近藤 高史
    第32回日本肥満学会  2011/09  淡路  (一社)日本肥満学会
  • だしのおいしさの秘密  [Invited]
    近藤高史
    味の素KKセミナー(大学)  2011/08  大阪  味の素(株)大阪支社
  • かつおだしのおいしさの秘密に迫る:脳に刷り込まれた伝統の味  [Invited]
    近藤高史
    広島大学大学院医歯薬学総合研究科セミナー  2011/07  広島  広島大学大学院医歯薬学総合研究科
  • だしのおいしさのメカニズム  [Invited]
    近藤高史
    「フードテクノひろしま」研究会 平成23年度第1回研究会  2011/07  広島  「フードテクノひろしま」研究会
  • かつおだしは何故おいしいか?  [Invited]
    近藤高史
    近畿大学農学部講義  2011/07  奈良  近畿大学農学部
  • Mystery of preference for dried-bonito dashi (a traditional Japanese fish stock): a complex world of taste and smell.  [Invited]
    Takashi Kondoh
    Seminar at the Department of otorhinolaryngology, University of Dresden Medical School  2011/07  Dresden  Department of otorhinolaryngology, University of Dresden Medical School
  • Learned preference for dried-bonito dashi (a traditional Japanese fish broth): a complex world of taste and smell.  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga; Hanae Yamazaki; Taiho Kambe; Masaya Nagao
    The 8th IBRO World Congress of Neuroscience  2011/07  Florence
  • Effect of dried-bonito dashi (a traditional Japanese broth) intake on glucose and fat metabolism and insulin secretion in KKAy mice.  [Not invited]
    Hanae Yamazaki; Tetsuro Matsunaga; Takashi Kondoh; Tohru Nishiyama; Masahiko Nonaka
    The 11th Asian Congress of Nutrition  2011/07  Singapore
  • Effects of dried-bonito broth on gastric myoelectrical activity and satiety in young healthy volunteers.  [Not invited]
    Tetsuro Matsunaga; Hanae Yamazaki; Kazushi Tanemura; Kinsuke Tsuda; Takashi Kondoh
    The 11th Asian Congress of Nutrition  2011/07  Singapore
  • Mystery of preference for dried-bonito dashi (a traditional Japanese fish stock): a complex world of taste and smell.  [Invited]
    Takashi Kondoh
    Seminar at the Institute of Physiology, Pécs University Medical School  2011/07  Pécs  Institute of Physiology, Pécs University Medical School
  • かつおだしの美味しさの秘密  [Invited]
    近藤高史
    産業医科大学医学部第1生理学 生理学セミナー  2011/07  北九州  産業医科大学医学部第1生理学
  • だし:脳に刷り込まれた伝統の味  [Invited]
    近藤高史
    名古屋市立大学医学部 生理学特別講義  2011/07  名古屋  名古屋市立大学医学部
  • うま味の生理機能  [Invited]
    近藤高史
    徳島大学医学部栄養学科 「栄養生理機能学」講義  2011/06  徳島  徳島大学医学部栄養学科
  • だし:脳に刷り込まれた伝統の味  [Invited]
    近藤高史
    徳島大学大学院ヘルスバイオサイエンス研究部 大学院特別講義  2011/06  徳島  徳島大学大学院ヘルスバイオサイエンス研究部
  • 食品科学研究の醍醐味ーだしのおいしさの秘密に迫るー  [Invited]
    近藤高史
    身体機能論・代謝機能論ゼミ(津田研究室)、京都大学大学院人間・環境学研究科共生人間学専攻認知情報学系認知行動科学講座身体機能論分野  2011/05  京都  身体機能論・代謝機能論ゼミ(津田研究室)、京都大学大学院人間・環境学研究科共生人間学専攻認知情報学系認知行動科学講座身体機能論分野
  • グレリンおよびグレリン受容体における遺伝子多型と摂取エネルギー量、胃運動機能、自律神経活動との関連解析  [Not invited]
    松永哲郎; 山崎英恵; 足達哲也; 安田浩一朗; 津田謹輔; 西山徹; 近藤高史; 野中雅彦
    第54回日本糖尿病学会年次学術集会  2011/05  札幌
  • だし:脳に刷り込まれた伝統の味  [Invited]
    近藤高史
    筑波大学附属駒場高等学校・校外学習(関西地域研究)  2011/05  京都  筑波大学附属駒場高等学校
  • かつおだし単回摂取のヒト胃運動および満腹感に対する効果  [Not invited]
    松永 哲郎; 山崎 英恵; 種村 一識; 津田 謹輔; 近藤 高史
    第65回日本栄養・食糧学会大会  2011/05  東京  (公社)日本栄養・食糧学会
  • コーヒー摂取が胃運動機能および自律神経活動に与える作用の検討  [Not invited]
    種村一識; 松永哲郎; 山崎英恵; 足達哲也; 近藤高史; 野中雅彦; 津田謹輔
    第65回日本栄養・食糧学会大会  2011/05  東京
  • Mechanisms of preference for dried-bonito dashi in rodents.  [Invited]
    Takashi Kondoh
    Seminar at the Department of Biology, University of Vermont  2011/04  Vermont  Department of Biology, University of Vermont
  • Mechanisms of preference for dried-bonito dashi in rodents.  [Invited]
    Takashi Kondoh
    Seminar at the Department of Psychology, Florida State University  2011/04  Florida  Department of Psychology, Florida State University
  • Preference for dried-bonito dashi (a traditional Japanese broth) in rodents.  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga; Hanae Yamazaki
    The 33rd Association for Chemoreception Sciences (AChemS 2011)  2011/04  St. Pete Beach
  • だしの生理機能  [Invited]
    近藤高史
    京都大学大学院生命科学研究科統合生命科学専攻生体情報応答学分野 永尾雅哉研究室セミナー  2011/04  京都  京都大学大学院生命科学研究科統合生命科学専攻生体情報応答学分野 永尾雅哉研究室
  • Preference for dried-bonito dashi (a traditional Japanese broth) in rats and mice.  [Not invited]
    Takashi Kondoh; Tetsuro Matsunaga; Hanae Yamazaki
    第88回日本生理学会大会  2011/03  Yokohama
  • Representation of umami taste in the forebrain.  [Invited]
    Hisao Nishijo; Etsuro Hori; Teruko Uwano; Takashi Kondoh; Taketoshi Ono
    Sponsored Symposium "Control of feeding behavior and digestion during meal due to maintenance of homeostasis”  2011/03  横浜  日本生理学会
  • だし:脳に刷り込まれた伝統の味  [Invited]
    近藤高史
    日本農芸化学会 第37回化学と生物シンポジウム「美味しく健康に生きるヒント - 知ってナットク!日本食の底力 -」  2011/03  京都  日本農芸化学会
  • うま味およびだしの生理機能-おいしく食べて健康づくり-  [Invited]
    近藤高史
    金沢大学フロンティアサイエンス機構 シンポジウム”「食」による生活習慣病予防医学の展開”  2011/02  金沢  金沢大学フロンティアサイエンス機構
  • Mechanisms of preference for dried-bonito dashi.  [Invited]
    近藤高史
    富山大学大学院医学薬学研究部(医学)システム情動科学 西条寿夫研究室セミナー  2011/02  富山  富山大学大学院医学薬学研究部(医学)システム情動科学 西条寿夫研究室
  • うま味およびだしの生理機能  [Invited]
    近藤高史
    鹿児島大学大学院医歯学総合研究科生体機能制御学講座口腔生理学分野 原田秀逸研究室セミナー  2010/12  鹿児島  鹿児島大学大学院医歯学総合研究科生体機能制御学講座口腔生理学分野 原田秀逸研究室
  • うま味新知見について―ここまでわかった、うま味の健康促進効果!―  [Invited]
    近藤高史
    トップ懇談会  2010/12  福岡  味の素株式会社
  • うま味新知見について―ここまでわかった、うま味の健康促進効果!―  [Invited]
    近藤高史
    トップ懇談会  2010/12  名古屋  味の素株式会社
  • うま味およびだしの生理機能  [Not invited]
    近藤高史
    第7回ENS研究会  2010/11  京都  ENS研究会
  • Recognition of deficient nutrients by the brain in lysine-deficient rats.  [Invited]
    Takashi Kondoh; Tomokazu Tsurugizawa; Makiko Kameishi; Miro Smriga; Kunio Torii
    The 8th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP)  2010/11  Fukuoka
  • Preference for dried-bonito dashi (a traditional Japanese broth) in rodents.  [Not invited]
    Takashi Kondoh; Hanae Yamazaki; Tetsuro Matsunaga
    The 8th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception  2010/11  Fukuoka
  • 「うま味新知見について―ここまでわかった、うま味の健康促進効果!  [Invited]
    近藤高史
    トップ懇談会  2010/09  札幌  味の素株式会社
  • うま味物質の生理機能  [Invited]
    近藤高史
    名古屋市立大学医学部 生理学特別講義  2010/07  名古屋  名古屋市立大学医学部医学科
  • 食事性グルタミン酸の生理機能  [Invited]
    近藤高史
    味の素製薬学術大賞講演会  2010/06  東京  味の素製薬(株)
  • 食事性グルタミン酸の生理機能  [Invited]
    近藤高史
    生涯学習研修会(大阪府栄養士会研修会)  2010/04  大阪  大阪府栄養士会
  • うま味の生理機能について-おいしく食べて健康づくり-  [Invited]
    近藤高史
    第18回岐阜県栄養改善学会  2010/02  岐阜  岐阜県栄養改善学会
  • 消化管におけるグルタミン酸シグナリングと脳腸相関  [Invited]
    近藤高史
    岐阜大学応用生物科学部獣医生理学 志水泰武研究室セミナー  2010/02  岐阜  岐阜大学応用生物科学部獣医生理学 志水泰武研究室
  • うま味の生理機能について-おいしく食べて健康づくり-  [Invited]
    近藤高史
    京都大学医学部医学研究科糖尿病・栄養内科 稲垣暢也研究室プログレスカンファレンス  2010/01  京都  京都大学医学部医学研究科糖尿病・栄養内科 稲垣暢也研究室
  • うま味の生理機能と脳腸相関  [Invited]
    近藤高史
    京都大学大学院生命科学研究科統合生命科学専攻生体情報応答学分野 永尾雅哉研究室セミナー  2009/12  京都  京都大学大学院生命科学研究科統合生命科学専攻生体情報応答学分野 永尾雅哉研究室
  • 口腔および消化管におけるグルタミン酸の受容機構と生理機能調節  [Invited]
    近藤高史
    京都大学心の未来研究センター 船橋新太郎研究室セミナー  2009/11  京都  京都大学心の未来研究センター 船橋新太郎研究室
  • Characteristics of rat hippocampal taste neurons.  [Not invited]
    Takashi Kondoh; Anh Son Ho; Etsuro Hori; Phuong Hong; Thi Nguyen; Susumu Urakawa; Kunio Torii; Taketoshi Ono; Hisao Nishijo
    The 7th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception.  2009/11  Fukuoka
  • Taste response of rat hippocampal neurons in different places.  [Not invited]
    Takashi Kondoh; Anh Son Ho; Etsuro Hori; Phuong Hong; Thi Nguyen; Susumu Urakawa; Kunio Torii; Taketoshi Ono; Hisao Nishijo
    第32回日本神経科学大会  2009/09  Nagoya
  • うま味物質摂取による生理機能調節  [Invited]
    近藤高史
    甲子園大学産学連携講義「フードデザイナー論I」  2009/08  宝塚  甲子園大学
  • ippocampal neuronal responses to gustatory stimuli in different places.  [Not invited]
    Takashi Kondoh; Anh Son Ho; Etsuro Hori; Phuong Hong; Thi Nguyen; Susumu Urakawa; Kunio Torii; Taketoshi Ono; Hisao Nishijo
    The 36th International Congress of Physiological Sciences (IUPS 2009)  2009/07  Kyoto
  • うま味物質摂取による生理機能調節  [Invited]
    近藤高史
    名古屋市立大学医学部医学科生理学特別講義  2009/07  名古屋  名古屋市立大学医学部医学科
  • Physiological roles of dietary glutamate.  [Invited]
    Takashi Kondoh
    The 102nd Annual Convention of the Philippine Medical Association (PMA)  2009/05  Manila  Philippine Medical Association (PMA)
  • ラットにおける栄養素摂取に対する脳応答メカニズムの解析  [Not invited]
    釣木澤朋和; 植松朗; 近藤高史; 畝山寿之; 鳥居邦夫
    第5回日本消化管学会総会学術集会  2009/02  東京
  • 消化管におけるグルタミン酸受容機構と脳腸相関  [Invited]
    近藤高史
    第51回日本消化器病学会大会 ブレックファーストセミナー  2009/02  京都  日本消化器病学会
  • うま味の脳科学研究  [Invited]
    近藤高史
    第6回医用分光学研究会  2009/02  川崎  医用分光学研究会
  • Enhancement of preference for flavors paired with intragastric administration of monosodium L-glutamate in rats.  [Not invited]
    Takashi Kondoh; Akira Uematsu; Tomokazu Tsurugizawa; Kunio Torii
    The 6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP)  2008/12  Fukuoka
  • Brain activation by dietary glutamate, and physiological significance.  [Invited]
    Takashi Kondoh
    Seminar at the John B. Pierce Laboratory in Yale University  2008/11  New Heaven  John B. Pierce Laboratory in Yale University
  • Activation of the gut-brain axis by dietary glutamate.  [Invited]
    Takashi Kondoh
    Seminar at Monell Chemical Senses Center  2008/11  Philadelphia  Monell Chemical Senses Center
  • Conditioned flavor preference learning by intragastric administration of glutamate in rats.  [Not invited]
    Akira Uematsu; Tomokazu Tsurugizawa; Takashi Kondoh; Hisayuki Uneyama; Kunio Torii
    The 38th Annual Meeting of the Society for Neuroscience  2008/11  Washington DC
  • Neural activity in rat forebrain regions induced by post-ingestive nutrients.  [Not invited]
    Tomokazu Tsurugizawa; Takashi Kondoh; Akira Uematsu; Kunio Torii
    The 38th Annual Meeting of the Society for Neuroscience  2008/11  Washington DC
  • グルタミン酸ナトリウム(MSG)摂取による脳活動上昇と肥満抑制  [Not invited]
    近藤高史; 鳥居邦夫
    第29回日本肥満学会  2008/10  大分
  • MSG ingestion activates several brain regions and reduces weight gain in rats.  [Not invited]
    Takashi Kondoh; Tomokazu Tsurugizawa; Kunio Torii
    The Obesity Society 2008 (NAASO 2008) Annual Scientific Meeting  2008/10  Phoenix
  • Recognition of deficient nutrients by the brain in lysine-deficient rats.  [Invited]
    Takashi Kondoh
    ’08 International Top Forum on Traditional Chinese Medicine (’08 ITFTCM)  2008/09  Liaoning
  • UEMATSU Akira; TSURUGIZAWA Tomokazu; KONDOH Takashi; TORII Kunio
    日本味と匂学会第42回大会  2008/09  富山  The Japanese Association for the Study of Taste and Smell
  • KONDOH Takashi; TSURUGIZAWA Tomokazu; TORII Kunio
    The Japanese Association for the Study of Taste and Smell  2008/09  富山  The Japanese Association for the Study of Taste and Smell
  • 栄養素摂取後に生じる脳活動変化と迷走神経の関与  [Not invited]
    釣木澤朋和; 近藤高史; 植松朗; 鳥居邦夫
    日本味と匂学会第42回大会  2008/09  富山
  • Brain activation induced by post-oral stimulation with taste substances in rats.  [Not invited]
    Takashi Kondoh; Tomokazu Tsurugizawa; Kunio Torii
    The 236th American Chemical Society (ACS) National Meeting  2008/08  Philadelphia
  • Suppression of obesity by spontaneous drinking of monosodium L-glutamate (MSG) solution in rats.  [Not invited]
    Takashi Kondoh; Kunio Torii
    The International Society for Olfaction and Taste (ISOT)  2008/07  San Francisco
  • Brain functional changes in rats administrated with the most preferable concentration of monosodium L-glutamate in the stomach.  [Invited]
    Takashi Kondoh; Tomokazu Tsurugizawa; Kunio Torii
    The 12th International Society for Olfaction and Taste (ISOT), Symposium “Glutamate signaling system during feeding and digestion process”  2008/07  San Francisco  International Society for Olfaction and Taste (ISOT)
  • Brain response and suppression of obesity by MSG intake in rats.  [Invited]
    Takashi Kondoh
    Global Umami Research Project in the USA (GURIP) Kickoff meeting  2008/07  San Francisco
  • Conditioned flavor preference learning by intragastric administration of glutamate in rats.  [Not invited]
    Akira Uematsu; Tomokazu Tsurugizawa; Takashi Kondoh
    The 16th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB)  2008/07  Paris
  • Brain activation by dietary glutamate via gustatory and vagus nerves, and its physiological significance on energy homeostasis.  [Invited]
    Takashi Kondoh
    The 16th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), Lunchon Seminar “Biological significance of glutamate signaling system during and after protein meal”  2008/07  Paris  The Society for the Study of Ingestive Behavior (SSIB)
  • 脳機能画像からのアプローチ ~うま味シグナリングの脳内処理機構~  [Invited]
    近藤高史; 釣木澤朋和; 鳥居邦夫
    第3回日本分子イメージング学会総会 シンポジウム「MRIと分子イメージング」  2008/05  大宮  日本分子イメージング学会
  • Post-oral nutritive substances elicit brain activation in rats.  [Not invited]
    Tomokazu Tsurugizawa; Takashi Kondoh; Kunio Torii
    The 16th International Society for Magnetic Resonance in Medicine (ISMRM)  2008/05  To
  • Tsurugizawa Tomokazu; Kondoh Takashi; Uematsu Akira; Torii Kunio
    第85回日本生理学会大会  2008/03  東京  PHYSIOLOGICAL SOCIETY OF JAPAN
  • Kondoh Takashi; Tsurugizawa Tomokazu; Torii Kunio
    第85回日本生理学会大会 シンポジウム「食行動におけるグルタミン酸シグナリングの役割」  2008/03  東京  PHYSIOLOGICAL SOCIETY OF JAPAN
  • 消化管におけるグルタミン酸シグナリングの内臓感覚及び脳機能に与える影響  [Invited]
    鳥居邦夫; 近藤高史; 釣木澤朋和; Ana San Gabriel; 畝山寿之
    第4回日本消化管学会総会学術集会 トピックスフォーラム「消化管グルタミン酸シグナリング研究の現状と今後」  2008/02  大阪  日本消化管学会
  • Intragastric glutamate elicits brain activation via vagus nerve in rats.  [Not invited]
    Tomokazu Tsurugizawa; Takashi Kondoh; Kunio Torii
    The 37th Annual Meeting of the Society for Neuroscience  2007/11  San Diego
  • Brain activation induced by post-oral stimuli with sweet, umami, and salty substances.  [Invited]
    Takashi Kondoh; Tomokazu Tsurugizawa; Kunio Torii
    The 5th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (ISMNTOP)  2007/11  Fukuoka
  • MSG ingestion reduces body weight, fat mass, and plasma leptin levels in rats.  [Not invited]
    Takashi Kondoh; Kunio Torii
    The Obesity Society 2007 (NAASO 2007) Annual Scientific Meeting  2007/10  New Orleans
  • TSURUGIZAWA Tomokazu; KONDOH Takashi; TORII Kunio
    日本味と匂学会第41回大会  2007/07  東京  The Japanese Association for the Study of Taste and Smell
  • メラトニンによる虚血性脳障害の抑制  [Invited]
    近藤高史
    第7回日本抗加齢医学会総会 ワークショップ「メラトニン-骨と脳への作用-」  2007/07  京都  日本抗加齢医学会
  • Shibata Ryoko; Kameishi Makiko; Kondoh Takashi; Torii Kunio
    第84回日本生理学会大会  2007/04  大阪  PHYSIOLOGICAL SOCIETY OF JAPAN
  • 食餌誘導性肥満のグルタミン酸ナトリウム(MSG)摂取による抑制  [Not invited]
    近藤高史; 鳥居邦夫
    第27回日本肥満学会  2006/10  神戸
  • Effects of dopaminergic lesions in the ventral tegmental area on tastes preference in rats.  [Not invited]
    Ryoko Shibata; Makiko Kameishi; Takashi Kondoh; Kunio Torii
    The 36th Annual Meeting of the Society for Neuroscience  2006/10  Atlanta
  • KONDOH Takashi; TORII Kunio
    日本味と匂学会第40回大会  2006/07  福岡  The Japanese Association for the Study of Taste and Smell
  • Visualization of rat brain areas activated on feeding behavior monitored by manganese-enhanced MRI.  [Not invited]
    Takashi Kondoh; Kunio Torii
    The 13th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB)  2005/07  Pittsburgh
  • Regulatory roles of LHA neurons on behavioral expression of taste preference and stress-induced responses.  [Invited]
    Takashi Kondoh; Hrudananda Mallick; Taketoshi Ono; Kunio Torii
    Golden jubilee Cerebration of;the;Association of;Physiologists;a;d;Pharmacologists of India;golden APPICON, Symposium “Lateral Hypothalamic Area - Revisited”  2004/12  Bangalore  The Association of Physiologists and Pharmacologists of India
  • 精油の匂いによるラット脳活動変化と神経投射のMRI解析  [Invited]
    近藤高史; 山田朱織; 塩田清二; 鳥居邦夫
    第7回日本アロマセラピー学会総会 シンポジウム「アロマの基礎研究」  2004/11  東京  日本アロマセラピー学会
  • Neuronal activities related to filial imprinting in the forebrain area of duckling.  [Not invited]
    Jiro Okuma; Masato Hoshino; Hiroyuki Furudate; Takashi Kondoh; Yasuhiro Kondoh; Hiroshi Tsujino; Kunio Torii; Tetsuya Kimura; Gen Matsumoto
    The 34th Annual Meeting of the Society for Neuroscience  2004/10  San Diego
  • Mapping filial imprinting-related activations in a bird brain by functional MRI.  [Not invited]
    Takashi Kondoh; Jiro Okuma; Kunio Torii; Gen Matsumoto; Yasuhiro Kondoh
    The 34th Annual Meeting of the Society for Neuroscience  2004/10  San Diego
  • Visualization of 6-hydroxydopamine-induced nigral lesions in rats by magnetic resonance imaging.  [Not invited]
    Takashi Kondoh; Makoto Bannai; Michio Takahashi; Hitoo Nishino; Kunio Torii
    第27回日本神経科学大会・第47回日本神経化学大会合同大会  2004/09  Osaka
  • Activation of higher brain centers in response to olfactory stimulation in rats.  [Invited]
    Takashi Kondoh; Shuori Yamada; Seiji Shioda; Kunio Torii
    Seminar at the Monell Chemical Senses Center  2004/07  Philadelphia  Monell Chemical Senses Center
  • Experience-based plastic changes in nucleus tractus solitarius neurons in lysine-deficient rats.  [Not invited]
    Takashi Kondoh; Eiichi Tabuchi; Hisao Nishijo; Ryoi Tamura; Taketoshi Ono; Kunio Torii
    The 12th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB)  2004/07  Cincinnati
  • Activation of higher brain centers in response to olfactory stimulation in rats.  [Invited]
    Takashi Kondoh; Shuori Yamada; Seiji Shioda; Kunio Torii
    Seminar at the Skirball Institute, New York University School of Medicine  2004/07  New York  Skirball Institute, New York University School of Medicine
  • Plastic changes in the nucleus tractus solitarius in response to gustatory stimulation in lysine-deficient rats.  [Not invited]
    Takashi Kondoh; Eiichi Tabuchi; Hisao Nishijo; Ryoi Tamura; Taketoshi Ono; Kunio Torii
    International Society for Olfaction and Taste / The Japanese Association for the Study of Taste and Smell 2004 (ISOT/JASTS 2004)  2004/07  Kyoto
  • Central olfactory pathway in response to olfactory stimulation in rats detected by magnetic resonance imaging.  [Invited]
    Takashi Kondoh; Shuori Yamada; Seiji Shioda; Kunio Torii
    The International Society for Olfaction and Taste / The Japanese Association for the Study of Taste and Smell 2004 (ISOT/JASTS 2004), Symposium “Neural and molecular basis for feeding and nutrition”  2004/07  Kyoto  ISOT/JASTS
  • Kondoh Takashi; Ueta Yoichi; Shibata Ryoko; Torii Kunio
    The Physiological Society of Japan  2004/06  札幌  PHYSIOLOGICAL SOCIETY OF JAPAN
  • Olfactory neural tract tracing by manganese-enhanced magnetic resonance imaging.  [Not invited]
    Takashi Kondoh; Ryoko Shibata; Kunio Torii
    The 12th International Society for Magnetic Resonance in Medicine (ISMRM)  2004/05  Kyoto
  • 欠乏栄養素に対する嗜好性発現機構  [Invited]
    近藤高史; 鳥居 邦夫
    平成15年度科学研究費補助金研究報告会  2004/03  京都
  • Rat strain differences and the contribution of vagus on NaCl preference/aversion.  [Not invited]
    Takashi Kondoh; Tatsuro Tanaka; Hisao Nishijo; Taketoshi Ono; Kunio Torii
    The 4th International Congress on Nutrition and Aging  2003/11  Tokyo
  • Olfactory tract tracing in rats by manganese-enhanced magnetic resonance imaging.  [Not invited]
    Takashi Kondoh; Ryoko Shibata; Hisayuki Uneyama; Kunio Torii
    The 33rd Annual Meeting of the Society for Neuroscience  2003/11  New Orleans
  • 近藤 高史; 柴田 良子; 鳥居 邦夫
    日本味と匂学会第37回大会  2003/09  岡山  日本味と匂学会
  • メラトニンによる虚血性脳障害の抑制  [Invited]
    近藤高史
    第5回産業生理セミナー  2003/07  北九州  産業医科大学医学部第1生理学
  • Melatonin reduces cerebral edema formation caused by transient forebrain ischemia in rats.  [Not invited]
    Takashi Kondoh; Hisayuki Uneyama; Hitoo Nishino; Kunio Torii
    第26回日本神経科学会大会  2003/07  Nagoya
  • Olfactory responses in the olfactory bulb, prefrontal cortex and the hypothalamus.  [Not invited]
    Takashi Kondoh; Shuori Yamada; Seiji Shioda; Kunio Torii
    The 11th International Society for Magnetic Resonance in Medicine (ISMRM)  2003/07  Toronto
  • Melatonin reduces ischemia-induced brain edema in MCA occlusion rats.  [Not invited]
    Takashi Kondoh; Hisayuki Uneyama; Hitoo Nishino; Kunio Torii
    The 11th International Society for Magnetic Resonance in Medicine (ISMRM)  2003/07  Toronto
  • Free behaving rats prefer BCAA-based solution to water during exercise: involvement of the brain 5-HT.  [Not invited]
    Makiko Kameishi; Miro Smriga; Tatsuro Tanaka; Takashi Kondoh; Kunio Torii
    第80回日本生理学会大会  2003/03  Fukuoka
  • Activation of higher brain centers in response to olfactory stimulation in rats detected by functional magnetic resonance imaging.  [Not invited]
    Takashi Kondoh; Shuori Yamada; Seiji Shioda; Kunio Torii
    第80回日本生理学会大会  2003/03  Fukuoka
  • Melatonin suppresses cerebral edema formation in MCA occlusion rats.  [Not invited]
    Kunio Torii; Hisayuki Uneyama; Hitoo Nishino; Takashi Kondoh
    第80回日本生理学会大会  2003/03  Fukuoka
  • カオリン水頭症ラットにおけるaquapolin1の発現変化  [Not invited]
    磯村健一; 間瀬光人; 相原徳孝; 真砂敦夫; 藤田政隆; 岡雄一; 近藤高史; 鳥居邦夫; 西野仁雄; 山田和雄
    第14回日本脳循環代謝学会総会  2002/11  大宮
  • Expression of aquapolins in kaolin induced hydrocephalus in rat brain.
    Kenichi Isomura; Mitsuhito Mase; Noritaka Aihara; Atsuo Masago; Masataka Fujita; Yuuichi Oka; Takashi Kondoh; Kunio Torii; Hitoo Nishino; Kazuo Yamada
    The XIIth International Symposium on Brain Edema and Brain Tissue Injury  2002/11  Hakone
  • 近藤 高史; 山田 朱織; 塩田 清二; 鳥居邦夫
    第5回日本アロマセラピー学会総会 シンポジウム「匂いのメカニズム」  2002/10  東京  日本アロマセラピー学会
  • Protective effect of melatonin on ischemic brain edema induced by middle cerebral artery occlusion in rats.  [Not invited]
    Hisayuki Uneyama; Takashi Kondoh; Hitoo Nishino; Kunio Torii
    International Symposium on Limbic and Association Cortical Systems  2002/10  Toyama
  • Brain activation in respond to olfactory stimulation in rats detected by functional magnetic resonance imaging.  [Not invited]
    Takashi Kondoh; Shuori Yamada; Seiji Shioda; Kunio Torii
    International Symposium on Limbic and Association Cortical Systems  2002/10  Toyama
  • カオリン水頭症ラットにおけるaquapolinesの発現変化  [Not invited]
    磯村健一; 間瀬光人; 相原徳孝; 真砂敦夫; 藤田政隆; 岡雄一; 近藤高史; 鳥居邦夫; 西野仁雄; 山田和雄
    第61回日本脳神経外科学会総会  2002/10  長野
  • Functional MRI を用いたラット脳ニオイ応答部位の解析  [Invited]
    近藤高史; 山田朱織; 塩田清二; 鳥居邦夫
    日本味と匂学会第36回大会 ワークショップ「こんな方法でこんなことがわかる:2002年の匂研究から例をとると」  2002/10  鹿児島  日本味と匂学会
  • Brain mechanism of learned preference for an essential amino acid, lysine, in rats with lysine deficiency.  [Invited]
    Kunio Torii; Miro Smriga; Takashi Kondoh
    The 10th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), Symposium “Nutritional neuroscience of amino acids: How the brain recognizes protein quality and adjusts ingestive behavior to spare protein”  2002/08  Santa Cruz  The Society for the Study of Ingestive Behavior (SSIB)
  • 自由走行ラットにおける分岐鎖アミノ酸を中心としたアミノ酸混合に対する嗜好性と脳内モノアミン分泌との関係  [Not invited]
    亀石真樹子; ミロ・スムリガ; 田中達朗; 近藤高史; 鳥居邦夫
    第56回日本栄養・食糧学会総会  2002/07  札幌
  • リジン欠乏食摂取に伴う迷走神経求心性線維の応答性と定量的リジン摂取の仕組み  [Not invited]
    鳥居邦夫; ミロ・スムリガ; 畝山寿之; 近藤高史; 新島旭; 小野武年
    第56回日本栄養・食糧学会総会  2002/07  札幌
  • カオリン水頭症ラットにおける水チャンネルの変化  [Not invited]
    磯村健一; 間瀬光人; 相原徳孝; 真砂敦夫; 藤田政隆; 岡雄一; 山田和雄; 近藤高史; 鳥居邦夫; 西野仁雄
    第5回脳浮腫・頭蓋内圧研究会  2002/07  東京
  • Early deficiency of an essential amino acid lysine is recognized by the ventromedial lateral hypothalamus.  [Not invited]
    Miro Smriga; Takashi Kondoh; Kunio Torii
    The 12th Annual Meeting of the International Behavioral Neuroscience Society (IBNS)  2002/06  Capri
  • 6-Hydroxydopamine-induced small brain edema detected by MRI: proposal of the best animal model for hemi-parkinson’s disease.  [Not invited]
    Takashi Kondoh; Makoto Bannai; Hisayuki Uneyama; Michio Takahashi; Hitoo Nishino; Kunio Torii
    The 10th International Society for Magnetic Resonance in Medicine (ISMRM)  2002/05  Honolulu
  • Melatonin reduces ischemia-induced brain edema in MCA occlusion rats.  [Not invited]
    Takashi Kondoh; Hisayuki Uneyama; Hitoo Nishino; Kunio Torii
    第3回「脳機能の解明」シンポジウム  2002/05  Nagoya
  • Proposal of the best animal model for hemi-Parkinson’s disease, and the effects of dopaminergic agonists on brain activation detected by MRI.  [Not invited]
    Takashi Kondoh; Hisayuki Uneyama; Hitoo Nishino; Kunio Torii
    Nagoya Symposium “Neural transplantation and repair of brain function”  2001/11  Nagoya
  • Behavioral evaluation of a relationship between the preference for branched-chain L-amino acids (BCAA) and physical exercise – the serotonergic hypothesis.  [Not invited]
    Miro Smriga; Makiko Kameishi; Takashi Kondoh; Kunio Torii
    The 11th Annual Meeting of the International Behavioral Neuroscience Society (IBNS)  2001/04  Cancun
  • Lysine attenuates neural excitability in the rat hypothalamic area.  [Not invited]
    Tatsuro Tanaka; Hrudananda Mallick; Hisayuki Uneyama; Takashi Kondoh; Taketoshi Ono; Kunio Torii
    The 30th Annual Meeting of the Society for Neuroscience  2000/11  New Orleans
  • KONDOH Takashi; MIRO Smriga; TANAKA Tatsuro; UNEYAMA Hisayuki; TORII Kunio
    日本味と匂学会第34会大会  2000/10  奈良  The Japanese Association for the Study of Taste and Smell
  • Taste-related functional changes in the hypothalamus during intake of glucose, monosodium L-glutamate (MSG) and NaCl in awake rats fed normal and non-protein diet.  [Not invited]
    Kunio Torii; Miro Smriga; Tatsuro Tanaka; Takashi Kondoh
    The 13th International Society for Olfaction and Taste (ISOT 2000) and 14th European Chemoreception Research Organization Congress (ECRO 2000)  2000/07  Brighton
  • Early L-lysine deficiency disturbs diurnal release of hypothalamic norepinephrine in rats.
    Kunio Torii; Miro Smriga; Tatsuro Tanaka; Takashi Kondoh
    Federation of American Societies for Experimental Biology 2000 (FASEB 2000)  2000/04  San Diego
  • Norepinephrine circadian release in the ventromedial hypothalamus is depressed during early amino acid deficiency.  [Not invited]
    Miro Smriga; Takashi Kondoh; Masato Mori; Kunio Torii
    The 10th Annual Meeting of the International Behavioral Neuroscience Society (IBNS)  2000/04  Denver
  • Brain fMRI signal changes in response to intraduodenal infusion of sweet amino acids in awake rats.  [Not invited]
    Takashi Kondoh; Miro Smriga; Taketoshi Ono; Kunio Torii
    The 8th International Society for Magnetic Resonance in Medicine (ISMRM)  2000/04  Denver
  • 機能的磁気共鳴画像(fMRI)法によるドパミンD2受容体ノックアウトマウス脳活動の解析  [Not invited]
    栗脇淳一; 近藤高史; 田村了以; 勝木元也; 餐場篤; 鳥居邦夫; 小野武年
    第77回日本生理学会大会  2000/03  横浜
  • Perception of L-glutamate in the taste bud of the tongue and sensors of the vagus nerve innervated into the alimentary organs in rats.  [Not invited]
    Kunio Torii; Takashi Kondoh; Tatsuroh Tanaka; Hisayuki Uneyama; Akira Niijima
    The 29th Annual Meeting of the Society for Neuroscience  1999/10  Miami Beach
  • ドパミンD2受容体ノックアウトマウスのfMRI法による脳活動の画像化  [Not invited]
    栗脇淳一; 近藤高史; 田村了以; 勝木元也; 餐場篤; 鳥居邦夫; 小野武年
    第46回中部日本生理学会  1999/10  名古屋
  • KONDOH Takashi; ZHOU Tian-Lu; ONO Taketoshi; TORII Kunio
    日本味と匂学会第33回大会  1999/10  東京  The Japanese Association for the Study of Taste and Smell
  • Central mechanism of preference for a deficient nutrient in L-lysine deficient rats.  [Invited]
    Kunio Torii; Masato Mori; Takashi Kondoh
    The Third International Conference on Nutrition and Aging  1999/09  Tokyo
  • Central mechanisms of preference for a deficient nutrients in L-lysine deficient rats.  [Not invited]
    Kunio Torii; Takashi Kondoh; Masato Mori; Taketoshi Ono
    The 8th Asian Congress of Nutrition (ACN)  1999/08  Seoul
  • Hypothalamic norepinephrine responses and daily diet intake patterns elicited by preferred or aversive MSG solutions in rats (operant-type and microdialysis evaluation).  [Not invited]
    Miro Smriga; Takashi Kondoh; Kunio Torii
    The 8th Annual Meeting of the International Behavioral Neuroscience Society (IBNS)  1999/06  Nancy
  • Central mechanisms of preference for a deficient nutrient in L-lysine deficient rats.  [Not invited]
    Kunio Torii; Takashi Kondoh; Masato Mori; Taketoshi Ono
    The 8th Annual Meeting of the International Behavioral Neuroscience Society (IBNS)  1999/06  Nancy
  • Changes in flow-weighted MR signals of the brain following intraduodenal infusion of monosodium L-glutamate and glucose in awake rats.  [Not invited]
    Takashi Kondoh; Taketoshi Ono; Kunio Torii
    7th International Society for Magnetic Resonance in Medicine (ISMRM)  1999/05  Philadelphia
  • Central mechanism for umami taste preference and aversion in rats.  [Invited]
    Kunio Torii; Masato Mori; Takashi Kondoh; Taketoshi Ono
    International Symposium of Glutamate  1998/10  Bergamo
  • 糖尿病における食物選択と脳での認知  [Invited]
    鳥居邦夫; 近藤高史; 森将人; 小野武年
    日本味と匂学会第32回大会 シンポジウム「食物選択における遺伝と環境:糖受容から代謝性疾患まで」  1998/10  郡山  日本味と匂学会
  • Central mechanisms for umami taste preference and aversion.  [Not invited]
    Kunio Torii; Takashi Kondoh; Miro Smriga; Masato Mori; Taketoshi Ono
    The 13th European Chemoreception Research Organization (ECRO 1998)  1998/09  Siena
  • Increases in cerebral and muscular blood flow detected by the flow-weighted MRI after an injection of pentobarbital in awake rats.  [Not invited]
    Takashi Kondoh; Taketoshi Ono; Kunio Torii
    The 6th International Society for Magnetic Resonance in Medicine (ISMRM)  1998/09  Sydney
  • Flow-weighted MR signal changes in awake rats before and after anesthesia.  [Not invited]
    Takashi Kondoh; Taketoshi Ono; Kunio Torii
    The 14th Annual Meeting of European society for Magnetic Resonance in Medicine and Biology (ESMRMB)  1997/09  Brussels
  • Control mechanism of preference for a deficient nutrient in L-lysine deficient rats by neuronal plasticity of its recognition site in the brain.
    Kunio Torii; Takashi Kondoh; Masato Mori; Taketoshi Ono
    The 16th International congress of Nutrition (ICN)  1997/08  Montreal
  • Functional MRl changes in the hypothalamus of streptozotocin-treated rats after glucose loading.  [Not invited]
    Kunio Torii; Takashi Kondoh; Masato Mori
    The 16th International Diabetes Federation (IDF) Congress  1997/07  Helsinki
  • Hypothalamic control of Amino Acid Appetite.  [Not invited]
    Kunio Torii; Takashi Kondoh; Masato Mori; Taketoshi Ono
    The 12th International Society for Olfaction and Taste / The 19th Annual Meeting of the Association for Chemoreception Sciences (ISOT/AChemS 1997)  1997/07  San Diego
  • ラットはどのように必須栄養素リジンの欠乏を知り適応するか  [Invited]
    鳥居邦夫; 近藤高史; 田渕英一; 森将人; 小野武年
    第30回日本味と匂のシンポジウム 特別企画1「映像で見る味と匂の研究」  1996/10  大阪
  • 脳機能と遺伝発現― リジン欠乏の認知と適応の仕組み―  [Not invited]
    鳥居邦夫; 近藤高史; 森将人; 小野武年
    第30回日本味と匂のシンポジウム  1996/10  大阪
  • Role of neurons in the ventromedial and lateral hypothalamus on selected ingestive behavior for umami taste materials and deficient nutrient, L-lysine.  [Invited]
    Hrudananda Mallick; Takashi Kondoh; Eiichi Tabuchi; Taketoshi Ono; Kunio Torii
    The First Federation of Asian and Oceanian Neuroscience Societies (FAONS) Congress - First International Brain Research Organization (IBRO) Regional Congress, Symposium “Umami taste preference”  1996/10  Pattaya
  • Control mechanism of preference for a deficient nutrient in L-lysine deficient rats by the plasticity of its recognition site in the brain, the lateral hypothalamic neurons responding to umami taste stimuli.  [Invited]
    Kunio Torii; Takashi Kondoh; Masato Mori; Taketoshi Ono
    The First Federation of Asian and Oceanian Neuroscience Societies (FAONS) Congress - First International Brain Research Organization (IBRO) Regional Congress, Symposium “Umami taste preference”  1996/10  Pattaya
  • Central mechanism of recognition and adaptation to nutritional deficiency of an essential L-amino acid, L-lysine, in rats.  [Invited]
    Kunio Torii; Takashi Kondoh; Yuzo Ninomiya; Akira Niijima; Taketoshi Ono
    Japan-Russia Joint Symposium  1996/10  Toyama
  • Hierarchy of chemical senses on selective L-lysine ingestion in rats with a L-lysine deficiency.  [Not invited]
    Kunio Torii; Takashi Kondoh; Yuzo Ninomiya; Akira Niijima; Taketoshi Ono
    The 12th European Chemoreception Research Organization (ECRO 1996)  1996/08  Zurich
  • 糖尿病ラットへのインスリン投与に伴う血糖値の変化と脳内での認知部位  [Not invited]
    鳥居邦夫; 余川隆; 森将人; 近藤高史; 小野武年
    第50回日本栄養・食糧学会大会  1996/04  京都
  • The anatomical levels at which lysine is recognized in rats given a lysine-deficient diet.  [Not invited]
    Kunio Torii; Takashi Kondoh; Yuzo Ninomiya; Akira Niijima; Eiichi Tabuchi; Taketoshi Ono
    The 18th Annual Meeting of the Association for Chemoreception Sciences (AChemS 1996)  1996/04  Sarasota
  • Behavioral and neural adaptation to lysine deficiency in rats exposed to L-amino acid solutions in choice paradigm.  [Not invited]
    Kunio Torii; Akira Niijima; Yuzo Ninomiya; Takashi Kondoh; Masato Mori; Takashi Yokawa; Eiichi Tabuchi; Taketoshi Ono
    Experimental Biology 96  1996/04  Washington DC
  • 田淵 英一; 余川 隆; 近藤 高史; 小野 武年; 鳥居 邦夫
    第29回味と匂のシンポジウム(1995年日本味と匂学会大会)  1995/09  東京  日本味と匂学会
  • Functional change in the brain of rats with insulin dependent diabetes mellitus after precipitous increase of glucose utilization by insulin injection using an MRI method.  [Not invited]
    Takashi Yokawa; Misako Takezawa; Eiichi Tabuchi; Takashi Kondoh; Hrudananda Mallick; Taketoshi Ono; Kunio Torii
    The 4th International Brain Research Organization (IBRO) World Congress of Neuroscience  1995/07  Kyoto
  • Hemodynamic of global cerebral ischemia in awake rat using MRI.  [Not invited]
    Eiichi Tabuchi; Takashi Yokawa; Takashi Kondoh; Hrudananda Mallick; Taketoshi Ono; Kunio Torii
    The 4th International Brain Research Organization (IBRO) World Congress of Neuroscience  1995/07  Kyoto
  • Responses of the ventromedial hypothalamic neurons to iontophoretic application of amino acids in awake rats.  [Not invited]
    Hrudananda Mallick; Takashi Kondoh; Eiichi Tabuchi; Takashi Yokawa; Taketoshi Ono; Kunio Torii
    The 4th International Brain Research Organization (IBRO) World Congress of Neuroscience  1995/07  Kyoto
  • Learning deficit after taste nerve sections on selective ingestive behavior for lysine in lysine-deficient rats.  [Not invited]
    Takashi Kondoh; Eiichi Tabuchi; Hrudananda Mallick; Taketoshi Ono; Kunio Torii
    The 4th International Brain Research Organization (IBRO) World Congress of Neuroscience  1995/07  Kyoto
  • Recognition of deficient nutrient intake in the brain of rat with L-lysine deficiency monitored by functional magnetic resonance imaging, electrophysiologically and behaviorally.  [Invited]
    Kunio Torii; Takashi Yokawa; Eiichi Tabuchi; Richard L Hawkins; Masato Mori; Takashi Kondoh; Taketoshi Ono
    The 4th International Brain Research Organization (IBRO) World Congress of Neuroscience, Symposium “Neural Control of Feeding”  1995/07  Kyoto  International Brain Research Organization (IBRO)
  • Functional MRI of awake rat: chronological changes of hemodynamics after a transient brain ischemia.  [Not invited]
    Eiichi Tabuchi; Takashi Yokawa; Takashi Kondoh; Hrudananda Mallick; Taketoshi Ono; Kunio Torii
    Perception, Memory, and Emotion: Frontier in Neuroscience  1995/07  Toyama
  • Iontophoretic application of amino acids to neurons in the ventromedial hypothalamus in awake rats with or without L-lysine deficiency.  [Not invited]
    Hrudananda Mallick; Takashi Kondoh; Eiichi Tabuchi; Takashi Yokawa; Taketoshi Ono; Kunio Torii
    Perception, Memory, and Emotion: Frontier in Neuroscience  1995/07  Toyama
  • Contribution of the chorda tympani and/or glossopharyngeal nerve to lysine preference in lysine-deficient rats.  [Not invited]
    Takashi Kondoh; Hrudananda Mallick; Eiichi Tabuchi; Taketoshi Ono; Kunio Torii
    Perception, Memory, and Emotion: Frontier in Neuroscience  1995/07  Toyama
  • The ventromedial hypothalamic neuronal responses to iontophoretic application of amino acids in lysine-deficient rats.  [Not invited]
    Hrudananda Mallick; Takashi Kondoh; Eiichi Tabuchi; Takashi Yokawa; Taketoshi Ono; Kunio Torii
    The 17th Annual Meeting of the Association for Chemoreception Sciences (AChemS 1995)  1995/04  Sarasota
  • Activated areas in the brain of awake rats during ingestion using magnetic resonance imaging (MRI).  [Not invited]
    Eiichi Tabuchi; Takashi Yokawa; Takashi Kondoh; Taketoshi Ono; Kunio Torii
    The 17th Annual Meeting of the Association for Chemoreception Sciences (AChemS 1995)  1995/04  Sarasota
  • Establishment of learned taste preference for lysine in lysine-deficient rats: roles of chorda tympani and glossopharyngeal nerves.  [Not invited]
    Takashi Kondoh; Hrudananda Mallick; Eiichi Tabuchi; Taketoshi Ono; Kunio Torii
    The 17th Annual Meeting of the Association for Chemoreception Sciences (AChemS 1995)  1995/04  Sarasota
  • 近藤 高史; 田渕 英一; 小野 武年; 鳥居 邦夫
    第28回味と匂のシンポジウム  1994/11  熊本  日本味と匂学会
  • Preference for L-amino acids in rats with or without L-lysine deficiency: the effect of bilateral taste nerve neurotomy.  [Not invited]
    Eiichi Tabuchi; Takashi Kondoh; Taketoshi Ono; Kunio Torii
    The 16th Annual Meeting of the Association for Chemoreception Sciences (AChemS 1994)  1994/04  Sarasota
  • Role of the nucleus tractus solitaries (NTS) in dietary regulation under essential nutrient deficiency.  [Not invited]
    Tentcho Voynikov; 近藤高史; 田渕英一; 小野武年; 鳥居邦夫
    第71回日本生理学会大会  1994/03  香川
  • SARTストレス状態ラット視床下部外側野におけるニューロン応答性
    近藤高史; 西条寿夫; 上野照子; 小野武年; 鳥居邦夫
    第71回日本生理学会大会  1994/03  香川
  • ラット鼓索神経および舌咽神経切除によるアミノ酸や食塩嗜好性の変化  [Not invited]
    田渕英一; 近藤高史; 上野照子; Tentcho Voynikov; 小野武年; 鳥居邦夫
    第71回日本生理学会大会  1994  香川
  • 蛋白質および必須アミノ酸欠乏時の食欲低下メカニズム― リジン欠乏ラットにおけるリジン摂取の認知部位とニューロンの応答性―
    鳥居邦夫; 田渕英一; 余川隆; 近藤高史; 村田拓也; 森将人; 小野武年
    第14回日本肥満学会  1993/10  盛岡
  • Response of lateral hypothalamic neurons to amino acids in lysine deficient rats.  [Not invited]
    Takashi Kondoh; Tentcho Voynikov; Eiichi Tabuchi; Kunio Torii; Masaji Fukuda; Taketoshi Ono
    The 11th International Conference on the Physiology of Food and Fluid Intake (ICPFFI 11)  1993/07  Oxford
  • Lateral hypothalamic neuronal responses to iontophoretic application of amino acids in rats under different nutritional conditions.  [Not invited]
    Eiichi Tabuchi; Takashi Kondoh; Tentcho Voynikov; Takashi Yokawa; Taketoshi Ono; Kunio Torii
    The 11th International Symposium on Olfaction and Taste (ISOT XI) / The 27th Japanese Symposium on Taste and Smell (JASTS XXVII)  1993/07  Sapporo
  • Responses of lateral hypothalamic neurons in lysine deficient rats.  [Not invited]
    Takashi Kondoh; Tentcho Voynikov; Eiichi Tabuchi; Takashi Yokawa; Taketoshi Ono; Kunio Torii
    The 11th International Symposium on Olfaction and Taste (ISOT XI) / The 27th Japanese Symposium on Taste and Smell (JASTS XXVII)  1993/07  Sapporo
  • Central function in preference for amino acids.  [Invited]
    Taketoshi Ono; Kunio Torii; Eiichi Tabuchi; Takashi Kondoh; Teruko Uwano
    The 11th International Symposium on Olfaction and Taste (ISOT XI) / The 27th Japanese Symposium on Taste and Smell (JASTS XXVII)  1993/07  Sapporo  ISOT/JASTS
  • リジン欠乏状態経験ラットにおける視床下部外側野ニューロンの味覚応答性  [Not invited]
    近藤高史; Tentcho Voynikov; 田渕英一; 鳥居邦夫; 小野武年
    第26回味と匂のシンポジウム  1992/12  東京
  • ニコチン性アセチルコリン受容体活性制御Ca2+ (RAMIC) に関連する細胞内影響因子の薬理学的作用スペクトルによる分類  [Not invited]
    恒枝宏史; 木村正康; 木村郁子; 出崎克也; 近藤高史; 三井健一郎; 日高弘義
    第65回日本薬理学会総会  1992/03  仙台
  • nAChR-activity modulating intracellular Ca2+ (RAMIC): its finding, properties and roles.  [Invited]
    Ikuko Kimura; Masayasu Kimura; Hiroshi Tsuneki; Takashi Kondoh
    The 3rd International Symposium on Excitation-Contraction Coupling in Skeletal, Cardiac and Smooth Muscle  1991/06  Banff
  • 糖尿病態は非収縮性細胞内Ca2+を介するニコチン性アセチルコリン受容体の脱感作を更に亢進する
    木村郁子; 恒枝宏史; 近藤高史; 木村正康
    第64回日本薬理学会総会  1991/03  神戸
  • 骨格筋アセチルコリン受容体活性を制御する細胞内カルシウム (RAMIC) とストレプトゾトシン糖尿病態による脱感作亢進  [Not invited]
    木村郁子; 恒枝宏史; 近藤高史; 木村正康
    第5回糖尿病動物研究会  1991/02  東京
  • Enhancing effects of nicotinic acetylcholine receptor channel blockers on the neuromuscular blocking action of succinylcholine and its diabetic modification in streptozotocin-mice.  [Invited]
    Ikuko Kimura; Hiroshi Tsuneki; Takashi Kondoh; Masayasu Kimura
    Lessons from Animal Diabetes 3rd International Workshop  1990/10  Tokyo
  • nAChR channel blockerはSuChによる筋細胞内Ca2+トランジェント抑制作用を増強する  [Not invited]
    木村郁子; 恒枝宏史; 近藤高史; 木村正康
    第41回日本薬理学会北部会  1990/10  福島
  • The inhibitory effects of neuromuscular blockers on nicotinic acetylcholine receptor-operated Ca2+ mobilization.
    Takashi Kondoh; Ikuko Kimura; Masayasu Kimura
    The 7th International Conference on Cyclic Nucleotides, Calcium, and Protein Phosphorylation (The Biology and Medicine of Signal Transduction)  1989/10  Kobe
  • Potentiation mechanism of succinylcholine and channel blockers in postsynaptic n-AChR-operated Ca2+ transients in phrenic nerve-diaphragm muscles of mice.  [Not invited]
    Takashi Kondoh; Ikuko Kimura; Hiroshi Tsuneki; Masayasu Kimura
    The 11th International Congress of Pharmacology  1989/07  Amsterdam
  • 神経筋シナプスにおけるスクシニルコリンの新しい作用機序
    木村郁子; 近藤高史; 木村正康
    第11回日本麻酔薬理学会  1989/06  千葉
  • Nicotinic acetylcholine receptor-mediated intracellular Ca2+ release.  [Invited]
    Ikuko Kimura; Takashi Kondoh; Masayasu Kimura
    The 9th International Washington Spring Symposium (Biology of Cellular Transducing Signals ’89)  1989/05  Washington DC
  • マウス横隔膜神経―横隔膜における間接および直接刺激によるエクオリン発光の対数と単収縮との非線型的相関  [Not invited]
    近藤高史; 木村郁子; 木村正康
    第62回日本薬理学会総会  1989/03  京都
  • 骨格筋アセチルコリン受容体が介在する細胞内Ca動員機構と糖尿病態  [Invited]
    木村郁子; 近藤高史; 木村正康
    第60回日本薬理学会総会シンポジウム  1989/03  京都
  • 糖尿病態と筋細胞内Caのアセチルコリン受容体への関与  [Invited]
    木村郁子; 近藤高史; 野島浩史; 木村正康
    第16回薬物活性シンポジウム  1988/10  富山
  • Diabetic state-induced alteration of acetylcholine receptor-mediated calcium transients in diaphragm muscles of streptozotocin-treated mouse.  [Invited]
    Ikuko Kimura; Takashi Kondoh; Masayasu Kimura
    The 6th International Symposium on Calcium-Binding Proteins in Health and Disease  1988/07  Nagoya
  • ブタ十二指腸輪走筋における高濃度K+のテトロドトキシン感受性86Rb efflux  [Not invited]
    近藤高史; 木村郁子; 木村正康
    第61回日本薬理学会総会  1988/03  福岡
  • コレシストキニン、K+、及び電気刺激によるブタ十二指腸輪走筋のテトロドトキシン感受性弛緩反応機構  [Invited]
    木村郁子; 近藤高史; 木村正康
    第60回日本薬理学会総会シンポジウム  1987/03  千葉  日本薬理学会
  • ブタ十二指腸輪走筋におけるドーパミン反応の二相性  [Not invited]
    木村郁子; 近藤高史; 木村正康
    第28回日本平滑筋学会総会  1986/06  東京
  • ブタ十二指腸輪走筋におけるcholecystokininの弛緩機構  [Not invited]
    木村郁子; 木村正康; 近藤高史
    第59回日本薬理学会総会  1986/04  新潟
  • A new potent CCK antagonist in the receptor for CCK-induced relaxation of pig duodenal circular muscle.  [Invited]
    Masayasu Kimura; Ikuko Kimura; Masaaki Kimura; Takashi Kondoh
    The 5th International Washington Spring Symposium –Neural & Endocrine Peptides & Receptors ’85  1985/05  Washington DC
  • 強力な新CCK拮抗薬:ブタ十二指腸輪走筋に対する弛緩作用の拮抗作用  [Not invited]
    木村正康; 木村郁子; 近藤高史; 木村雅昭; 新田昌宏; 井内浤二; 塚本悟郎
    第35回日本薬理学会北部会  1984/10  新潟

MISC

Awards & Honors

  • 2013/01 The Japanese Journal of Taste and Smell Research Article of the Year 2012 prize
     すぐき汁の味成分分析-かぶら汁との比較- 
    受賞者: Takashi Kondoh;Kazuhiro Nakamura
  • 1997/09 The European Society for Magnetic Resonance in Medicine and Biology Poster Award (Gold Prize)
     Flow-weighted MR signal changes in awake rats before and after anesthesia 
    受賞者: Takashi Kondoh;Taketoshi Ono;Kunio Torii

Research Grants & Projects

  • 食べ合わせを起因とする餅の味覚変調作用(苦味発生)の検討
    公益財団法人飯島藤十郎記念食品科学振興財団:2023年度学術研究助成金(個人研究)
    Date (from‐to) : 2024/04 -2025/03 
    味覚変調作用とは、ある化合物/食品の味が、他の化合物/食品を味わうことによって異なる味へと変化する現象をいう。餅は甘いが、ある甘い市販飲料(アクエリアスなど)と一緒に食べると強い苦味を発生する。しかしそのメカニズムは不明である。われわれは、餅に含まれる成分(中性では苦くない;水やお茶では苦味を発生しない)が、酸性飲料を一緒に摂ることによって強い苦味を発生することを見出した。そこで、本研究では、1)いろいろな穀物、でんぷん、あるいは再加工餅などを用いて苦味を発生する食糧を特定し、2)苦味物質の存在形態を調べることにより、味覚変調(苦味発生)のメカニズムを総合的に解明する。食べ合わせにより不快な味に変わる現象のメカニズムを解明することができれば、よりおいしい食べ方の提案/啓発、さらには苦味を発生させないおいしい食品の開発につながると期待できる。ホットかつ斬新な話題であるため、マスメディアの興味を引く内容であり、一般消費者へのインパクトも大きい。
  • 公益財団法人ソルト・サイエンス研究財団:2023年度研究助成(一般公募研究)
    Date (from‐to) : 2023/04 -2024/03 
    Author : 近藤高史

Teaching Experience

  • PhysiologyPhysiology Nagoya City University

Committee Membership

  • 2006/04 - Today   The Japan Emotionology Society   Councilor
  • 1999/04 - Today   The Japanese Association for the Study of Taste and Smell   Councilor
  • 2003/04 -2009/03   The Japanese Association for the Study of Taste and Smell   Board Member

Social Contribution

Media Coverage

  • おいしさの先にある健康効果を解き明かす
    Date : 2021/07
    Writer: Other than myself
    Publisher, broadcasting station: 株式会社ニュートンプレス
    Program, newspaper magazine: ニュートン別冊 近畿大学大解剖Vol.2
    114-115ページ Paper
  • 心身の健康 かつおだしで
    Date : 2018/03/17
    Writer: Other than myself
    Program, newspaper magazine: 東奥日報新聞
    Paper
  • エノキのやせスープ
    Date : 2016/08
    Writer: Other than myself
    Program, newspaper magazine: 日経ヘルス
    221巻32ページ Paper
  • 連載『旬の食材・カツオ節』
    Date : 2015/11
    Writer: Other than myself
    Program, newspaper magazine: 日経ヘルス
    212巻108ページ Paper
  • 愛知学院大・モーニングセミナー
    Date : 2015/06/07
    Writer: Other than myself
    Program, newspaper magazine: 中日新聞
    朝刊 Paper
  • お茶の間学Ⅰ だし 心身を育む
    Date : 2015/06/03
    Writer: Other than myself
    Program, newspaper magazine: 西日本新聞
    Paper
  • 味噌汁を再考する4つの論点
    Date : 2015/05/28
    Writer: Other than myself
    Program, newspaper magazine: Sports Graphic Number Do
    文藝春秋社 Paper
  • Clinical Topics:和食の基本“かつおだし”の機能性、科学的解明が進む
    Date : 2015/03/26
    Writer: Other than myself
    Program, newspaper magazine: Medical Tribune
    第48巻13号 Paper
  • だしの健康効果に迫る
    Date : 2014/07/18
    Writer: Other than myself
    Program, newspaper magazine: 食品新聞
    Paper
  • おいしさと健康、十勝から食提案
    Date : 2014/07/17
    Program, newspaper magazine: 十勝毎日新聞
    Paper
  • カツオ節の歴史、食文化学ぶ
    Date : 2013/04/24
    Writer: Other than myself
    Program, newspaper magazine: 水産経済新聞
    Paper
  • 「摂取経験に強く依存」天然カツオだしの嗜好性
    Date : 2013/04/23
    Writer: Other than myself
    Program, newspaper magazine: みなと新聞
    Paper
  • 健康だし、おいしいし
    Date : 2012/09/14
    Program, newspaper magazine: 中日新聞
    朝刊 Paper
  • 健康だし、おいしいし
    Date : 2012/09/13
    Writer: Other than myself
    Program, newspaper magazine: 中日新聞
    夕刊 Paper
  • かつおだし 健康に効用
    Date : 2012/08/15
    Writer: Other than myself
    Program, newspaper magazine: 京都新聞
    朝刊 Paper
  • 「はなまるマーケット」 取材協力
    Date : 2012
    Writer: Other than myself
    Publisher, broadcasting station: TBS局
    Media report
  • かつおだし 満腹感効果 習慣化で肥満防止の可能性
    Date : 2011/09/23
    Writer: Other than myself
    Program, newspaper magazine: 中日新聞
    朝刊 Paper

Academic Contribution

  • Frontiers in Behavioral Neuroscience, Associate Editor
    Date (from-to) :2020/04-Today
    Role: Peer review
    Type: Review
  • 日本味と匂学会誌 査読委員
    Date (from-to) :1999/04-Today
    Role: Peer review
    Type: Review
  • External examiner of the PhD student in Universiti Kebangsaan Malaysia
    Date (from-to) :2020/12-2021/04
    Role: Review
    Type: Review
  • The 5th Central European Congress on Obesity (CECON), Symposium "Central regulation of energy balance, hunger and satiety", chairman
    Date (from-to) :2015/10/01-2015/10/03
    Role: Panel chair etc
    Type: Academic society etc
    Budapest, Hungary
  • シンポジウム「だしのおいしさと健康機能 ~ここまでわかった、かつおだしの秘密~」
    Date (from-to) :2012/08/24-2012/08/24
    Role: Planning etc
    Type: Competition etc
    Organizer, responsible person: 京都大学大学院農学研究科食の未来戦略講座(味の素寄附講座) 近藤高史
  • 2011 Annual Meeting of the International Society for Nutraceuticals and Functional Foods (2011 ISNFF), Session 24: Functional Foods Formulation-1, chairman
    Date (from-to) :2011/11/14-2011/11/17
    Role: Panel chair etc
    Type: Academic society etc

Other link

researchmap



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