ISHII Kazunari

Researcher Information

URL

https://orcid.org/0000-0001-6601-952X

Research funding number

• 50534103

ORCID ID

•  https://orcid.org/0000-0001-6601-952X

J-Global ID

• 201401001414494301

Research Interests

• normal pressure hydrocephalus   Tau PET   Amyloid PET   Lewy body disease   Alzheimer   dementia   レビー小体型認知症   FDG-PET   MRI   アミロイドイメージング   アルツハイマー病   認知症   

Research Areas

• Life sciences / Radiology

Academic & Professional Experience

• 2019/04 - Today  Kindai UniversityFaculty of Medicine主任教授
• 2012/04  Kindai UniversityFaculty of Medicine教授
• 2009  Kindai UniversityFaculty of Medicine准教授

Education

• 1980/04 - 1986/03  Kobe University  School of Medicine

Association Memberships

• 日本磁気共鳴医学会   日本インターベンショナルラジオロジー学会（日本IVR学会）   European Society of Radiology   Radiological Society of North America   Society of Nuclear Medicine   日本神経放射線学会   日本医学放射線学会   日本核医学会   

Published Papers

• Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports

  Hiroyuki Fujii; Mitsuru Matsuki; Takefumi Hamakawa; Yumiko Toda; Nana Fujii; Sota Masuoka; Akihiro Nakamata; Emiko Chiba; Kazunari Ishii; Harushi Mori

  Radiology Case Reports 2024/05
• Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods.

  Cong Shang; Keita Sakurai; Takashi Nihashi; Yutaka Arahata; Akinori Takeda; Kazunari Ishii; Kenji Ishii; Hiroshi Matsuda; Kengo Ito; Takashi Kato; Hiroshi Toyama; Akinori Nakamura

  Annals of nuclear medicine 2024/03 

  OBJECTIVE: The Centiloid (CL) scale is a standardized measure for quantifying amyloid deposition in amyloid positron emission tomography (PET) imaging. We aimed to assess the agreement among 3 CL calculation methods: CapAIBL, VIZCalc, and Amyquant. METHODS: This study included 192 participants (mean age: 71.5 years, range: 50-87 years), comprising 55 with Alzheimer's disease, 65 with mild cognitive impairment, 13 with non-Alzheimer's dementia, and 59 cognitively normal participants. All the participants were assessed using the three CL calculation methods. Spearman's rank correlation, linear regression, Friedman tests, Wilcoxon signed-rank tests, and Bland-Altman analysis were employed to assess data correlations, linear associations, method differences, and systematic bias, respectively. RESULTS: Strong correlations (rho = 0.99, p < .001) were observed among the CL values calculated using the three methods. Scatter plots and regression lines visually confirmed these strong correlations and met the validation criteria. Despite the robust correlations, a significant difference in CL value between CapAIBL and Amyquant was observed (36.1 ± 39.7 vs. 34.9 ± 39.4; p < .001). In contrast, no significant differences were found between CapAIBL and VIZCalc or between VIZCalc and Amyquant. The Bland-Altman analysis showed no observable systematic bias between the methods. CONCLUSIONS: The study demonstrated strong agreement among the three methods for calculating CL values. Despite minor variations in the absolute values of the Centiloid scores obtained using these methods, the overall agreement suggests that they are interchangeable.
• Examining Frontal Lobe Asymmetry and Its Potential Role in Aggressive Behaviors in Early Alzheimer's Disease.

  Hiroshi Kameyama; Kenji Tagai; Emi Takasaki; Tetsuo Kashibayashi; Ryuichi Takahashi; Hideki Kanemoto; Kazunari Ishii; Manabu Ikeda; Masatoshi Shigeta; Shunichiro Shinagawa; Hiroaki Kazui

  Journal of Alzheimer's disease : JAD 2024/02 

  BACKGROUND: Neuropsychiatric symptoms (NPS) in patients with dementia lead to caregiver burdens and worsen the patient's prognosis. Although many neuroimaging studies have been conducted, the etiology of NPS remains complex. We hypothesize that brain structural asymmetry could play a role in the appearance of NPS. OBJECTIVE: This study explores the relationship between NPS and brain asymmetry in patients with Alzheimer's disease (AD). METHODS: Demographic and MRI data for 121 mild AD cases were extracted from a multicenter Japanese database. Brain asymmetry was assessed by comparing the volumes of gray matter in the left and right brain regions. NPS was evaluated using the Neuropsychiatric Inventory (NPI). Subsequently, a comprehensive assessment of the correlation between brain asymmetry and NPS was conducted. RESULTS: Among each NPS, aggressive NPS showed a significant correlation with asymmetry in the frontal lobe, indicative of right-side atrophy (r = 0.235, p = 0.009). This correlation remained statistically significant even after adjustments for multiple comparisons (p <  0.01). Post-hoc analysis further confirmed this association (p <  0.05). In contrast, no significant correlations were found for other NPS subtypes, including affective and apathetic symptoms. CONCLUSIONS: The study suggests frontal lobe asymmetry, particularly relative atrophy in the right hemisphere, may be linked to aggressive behaviors in early AD. These findings shed light on the neurobiological underpinnings of NPS, contributing to the development of potential interventions.
• Generating PET Attenuation Maps via Sim2Real Deep Learning–Based Tissue Composition Estimation Combined with MLACF

  Tetsuya Kobayashi; Yui Shigeki; Yoshiyuki Yamakawa; Yumi Tsutsumida; Tetsuro Mizuta; Kohei Hanaoka; Shota Watanabe; Daisuke Morimoto‑Ishikawa; Takahiro Yamada; Hayato Kaida; Kazunari Ishii

  Journal of Imaging Informatics in Medicine Springer Science and Business Media LLC 2024/01
• Imaging Characteristics of Hypervascular Focal Nodular Hyperplasia-Like Lesions in Patients with Chronic Alcoholic Liver Disease

  Kazunari Ishii

  2023/12
• 軽度認知障害及び認知症の行動・心理症状への白質病変の影響

  片上 茂樹; 鐘本 英輝; 垰本 大喜; 佐竹 祐人; 末廣 聖; 佐藤 俊介; 竹田 佳世; 吉山 顕次; 樫林 哲雄; 高橋 竜一; 互 健二; 品川 俊一郎; 石井 一成; 數井 裕光; 池田 学

  老年精神医学雑誌 (株)ワールドプランニング 34 (増刊II) 197 - 197 0915-6305 2023/10
• MCIおよび早期AD/DLBにおける脳年齢と神経精神症状の関連性 多施設共同研究

  曽根 大地; 互 健二; 品川 俊一郎; 樫林 哲雄; 高橋 竜一; 石井 一成; 鐘本 英輝; 池田 学; 繁田 雅弘; 數井 裕光

  Dementia Japan (一社)日本認知症学会 37 (4) 670 - 670 1342-646X 2023/10
• アルツハイマー型認知症における行動・心理症状と脳形態の左右差との関連

  亀山 洋; 互 健二; 高崎 恵美; 樫林 哲雄; 高橋 竜一; 鐘本 英輝; 石井 一成; 池田 学; 繁田 雅弘; 品川 俊一郎; 數井 裕光

  老年精神医学雑誌 (株)ワールドプランニング 34 (増刊II) 197 - 197 0915-6305 2023/10
• Differential diagnosis of MCI with Lewy bodies and MCI due to Alzheimer’s disease by visual assessment of occipital hypoperfusion on SPECT images

  Takashi Nakata; Kenichi Shimada; Akiko Iba; Haruhiko Oda; Akira Terashima; Yutaka Koide; Ryota Kawasaki; Takahiro Yamada; Kazunari Ishii

  Japanese Journal of Radiology 2023/10 [Refereed]
   

  Abstract Purpose Predicting progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) or dementia with Lewy bodies (DLB) is important. We evaluated morphological and functional differences between MCI with Lewy bodies (MCI-LB) and MCI due to AD (MCI-AD), and a method for differentiating between these conditions using brain MRI and brain perfusion SPECT. Methods A continuous series of 101 subjects, who had visited our memory clinic and met the definition of MCI, were enrolled retrospectively. They were consisted of 60 MCI-LB and 41 MCI-AD subjects. Relative cerebral blood flow (rCBF) on SPECT images and relative brain atrophy on MRI images were evaluated. We performed voxel-based analysis and visually inspected brain perfusion SPECT images for regional brain atrophy, occipital hypoperfusion and the cingulate island sign (CIS), for differential diagnosis of MCI-LB and MCI-AD. Results MRI showed no significant differences in regional atrophy between the MCI-LB and MCI-AD groups. In MCI-LB subjects, occipital rCBF was significantly decreased compared with MCI-AD subjects (p < 0.01, family wise error [FWE]-corrected). Visual inspection of occipital hypoperfusion had sensitivity, specificity, and accuracy values of 100%, 73.2% and 89.1%, respectively, for differentiating MCI-LB and MCI-AD. Occipital hypoperfusion was offered higher diagnostic utility than the CIS. Conclusions The occipital lobe was the region with significantly decreased rCBF in MCI-LB compared with MCI-AD subjects. Occipital hypoperfusion on brain perfusion SPECT may be a more useful imaging biomarker than the CIS for visually differentiating MCI-LB and MCI-AD.
• Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls.

  Hiroki Masuda; Masahiro Mori; Shigeki Hirano; Akiyuki Uzawa; Tomohiko Uchida; Mayumi Muto; Ryohei Ohtani; Reiji Aoki; Yoshiyuki Hirano; Satoshi Kuwabara

  Scientific reports 13 (1) 12631 - 12631 2023/08 

  We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer's Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. - 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman's rho =  - 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman's rho =  - 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD.
• 異所性静脈瘤の治療戦略 十二指腸静脈瘤の血行動態とIVR治療

  鶴崎 正勝; 小寺 卓; 上月 瞭平; 浦瀬 篤史; 逢坂 友也; 松井 繁長; 杉本 幸司; 石井 一成; 工藤 正俊

  日本門脈圧亢進症学会雑誌 (一社)日本門脈圧亢進症学会 29 (3) 73 - 73 1344-8447 2023/08
• アルツハイマー型認知症患者における抑うつに対する病態失認の神経基盤について

  末廣 聖; 鐘本 英輝; 垰夲 大喜; 佐竹 祐人; 佐藤 俊介; 片上 茂樹; 竹田 佳世; 吉山 顕次; 樫林 哲雄; 高橋 竜二; 互 健二; 品川 俊一郎; 石井 一成; 數井 裕光; 池田 学

  日本神経心理学会総会プログラム・予稿集 日本神経心理学会 47回 109 - 109 2023/08
• 異所性静脈瘤の治療戦略 十二指腸静脈瘤の血行動態とIVR治療

  鶴崎 正勝; 小寺 卓; 上月 瞭平; 浦瀬 篤史; 逢坂 友也; 松井 繁長; 杉本 幸司; 石井 一成; 工藤 正俊

  日本門脈圧亢進症学会雑誌 (一社)日本門脈圧亢進症学会 29 (3) 73 - 73 1344-8447 2023/08
• アルツハイマー型認知症における虚再認の脳内基盤の検討

  茶谷 佳宏; 藤戸 良子; 木村 直広; 河合 亮; 樫林 哲雄; 高橋 竜一; 鐘本 英輝; 互 健二; 品川 俊一郎; 石井 一成; 池田 学; 數井 裕光

  日本神経心理学会総会プログラム・予稿集 日本神経心理学会 47回 127 - 127 2023/08
• アルツハイマー病および健忘性軽度認知障害では易刺激性と島皮質の血流低下が関連する

  高橋 竜一; 樫林 哲雄; 鐘本 英輝; 池田 学; 石井 一成; 互 健二; 品川 俊一郎; 數井 裕光

  日本神経心理学会総会プログラム・予稿集 日本神経心理学会 47回 137 - 137 2023/08
• アルツハイマー型認知症患者における抑うつに対する病態失認の神経基盤について

  末廣 聖; 鐘本 英輝; 垰山 大喜; 佐竹 祐人; 佐藤 俊介; 片上 茂樹; 竹田 佳世; 吉山 顕次; 樫林 哲雄; 高橋 竜二; 互 健二; 品川 俊一郎; 石井 一成; 數井 裕光; 池田 学

  日本神経心理学会総会プログラム・予稿集 日本神経心理学会 47回 109 - 109 2023/08
• Prognostic significance of the harmonized maximum standardized uptake value of 18F-FDG-PET/CT in patients with resectable oral tongue squamous cell carcinoma: A multicenter study.

  Hayato Kaida; Kazuhiro Kitajima; Tetsuro Sekine; Kimiteru Ito; Hiromitsu Daisaki; Takayuki Kimura; Mitsuo P Sato; Akifumi Enomoto; Naoki Otsuki; Kazunari Ishii

  Dento maxillo facial radiology 20230083 - 20230083 2023/07 

  OBJECTIVES: To investigate the usefulness of harmonized 18F-FDG-PET/CT parameters for predicting the postoperative recurrence and prognosis of oral tongue squamous cell carcinoma (OTSCC). METHODS: We retrospectively analyzed the cases of 107 OTSCC patients who underwent surgical resection at four institutions in Japan in 2010-2016 and evaluated the harmonized PET parameters of the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for the primary tumor as the pSUVmax, pMTV, and pTLG. For lymph node metastasis, we used harmonized PET parameters of nodal-SUVmax, nodal-total MTV (tMTV), and nodal-total TLG (tTLG). The associations between the harmonized PET parameters and the patients' relapse-free survival (RFS) and overall survival (OS) were evaluated by the Kaplan-Meier method and Cox proportional hazard regression analysis for model 1 (preoperative stage) and model 2 (preoperative   +  postoperative stages). RESULTS: The harmonized SUVmax values were significantly lower than those before harmonization (p=0.012). The pSUVmax was revealed as a significant preoperative risk factor for RFS and OS. Nodal-SUVmax, nodal-tMTV, and nodal-tTLG were significant preoperative risk factors for OS. The combination of pSUVmax + nodal-SUVmax significantly stratified the patients into a low-risk group (pSUVmax <3.97 + nodal-SUVmax <2.85 or ≥2.85) and a high-risk group (pSUVmax ≥3.97 + nodal-SUVmax <2.85 or pSUVmax ≥3.97 + nodal-SUVmax ≥2.85) for recurrence and prognosis (RFS: p=0.001; OS: p<0.001). CONCLUSIONS: The harmonized pSUVmax is a significant prognostic factor for the survival of OTSCC patients. The combination of pSUVmax and nodal-SUVmax identified OTSCC patients at high risk for recurrence and poor prognosis at the preoperative stage.
• Noise reduction performance of a deep learning-based reconstruction in brain computed tomography images acquired with organ-based tube current modulation

  Shota Watanabe; Yuki Kono; Shigetoshi Kitaguchi; Hiroyuki Kosaka; Kazunari Ishii

  Physical and Engineering Sciences in Medicine Springer Science and Business Media LLC 46 (3) 1153 - 1162 2662-4729 2023/06 

  We aimed to evaluate the image quality of brain computed tomography (CT) images reconstructed using deep learning-based reconstruction (DLR) in organ-based tube current modulation (OB-TCM) acquisition. An anthropomorphic head phantom and a cylindrical low-contrast phantom were scanned at the standard dose level for adult brain CT in axial volume acquisition without OB-TCM. Moreover, image acquisition with OB-TCM was performed. The radiation dose on the eye lens was measured using a scintillation fibre-optic dosimeter placed on the anthropomorphic phantom's eye surface. The task transfer function (TTF), contrast-to-noise ratio (CNR), and low-contrast object specific CNR obtained from low-contrast phantom images reconstructed with filtered back projection (FBP), hybrid iterative reconstruction (HIR), and two types of DLR (DLRCTA and DLRLCD) were compared. In result, OB-TCM achieved a 32.5% dose reduction in the eye lens. Although HIR, DLRCTA, and DLRLCD showed lower TTF than FBP, the difference in TTF at the highest contributing spatial frequency corresponding to the contrast rod diameter was < 10%. Despite the OB-TCM acquisition, DLRCTA and DLRLCD achieved significantly lower noise and a higher CNR than FBP without OB-TCM (p < 0.05). However, low-contrast object specific CNR was equivalent among all reconstruction methods for the objective diameter of 5 mm and slightly improved in DLRLCD for the objective diameter of 7 mm. DLR with OB-TCM acquisition enabled dose reduction for the eye lens and high CNR image appearance, whereas the low contrast detectability evaluated by low-contrast object specific CNR did not always improve.
• Prognostic role of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography with an image-based harmonization technique: A multicenter retrospective study.

  Akira Hamada; Kazuhiro Kitajima; Kenichi Suda; Takamasa Koga; Junichi Soh; Hayato Kaida; Kimiteru Ito; Tetsuro Sekine; Kyoshiro Takegahara; Hiromitsu Daisaki; Masaki Hashimoto; Yukihiro Yoshida; Takanobu Kabasawa; Takashi Yamasaki; Seiichi Hirota; Jitsuo Usuda; Kazunari Ishii; Tetsuya Mitsudomi

  JTCVS open 14 502 - 522 2023/06 

  OBJECTIVES: Despite the prognostic impacts of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examination, fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography-based prognosis prediction has not been used clinically because of the disparity in data between institutions. By applying an image-based harmonized approach, we evaluated the prognostic roles of fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters in clinical stage I non-small cell lung cancer. METHODS: We retrospectively examined 495 patients with clinical stage I non-small cell lung cancer who underwent fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examinations before pulmonary resection between 2013 and 2014 at 4 institutions. Three different harmonization techniques were applied, and an image-based harmonization, which showed the best-fit results, was used in the further analyses to evaluate the prognostic roles of fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters. RESULTS: Cutoff values of image-based harmonized fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters, maximum standardized uptake, metabolic tumor volume, and total lesion glycolysis were determined using receiver operating characteristic curves that distinguish pathologic high invasiveness of tumors. Among these parameters, only the maximum standardized uptake was an independent prognostic factor in recurrence-free and overall survivals in univariate and multivariate analyses. High image-based maximum standardized uptake value was associated with squamous histology or lung adenocarcinomas with higher pathologic grades. In subgroup analyses defined by ground-glass opacity status and histology or by clinical stages, the prognostic impact of image-based maximum standardized uptake value was always the highest compared with other fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography parameters. CONCLUSIONS: The image-based fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography harmonization was the best fit, and the image-based maximum standardized uptake was the most important prognostic marker in all patients and in subgroups defined by ground-glass opacity status and histology in surgically resected clinical stage I non-small cell lung cancers.
• 当院における難治性腹水に対するデンバーシャントの有用性

  浦瀬 篤史; 鶴崎 正勝; 小寺 卓; 上月 暸平; 平山 歩; 石井 一成; 青木 智子; 工藤 正俊

  日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 143 - 143 1340-4520 2023/04
• 胃静脈瘤に対するCANDISを用いたB-RTOの中期成績と肝予備能温存における効果

  小寺 卓; 鶴崎 正勝; 浦瀬 篤史; 上月 瞭平; 平山 歩; 石井 一成; 青木 智子; 工藤 正俊

  日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 216 - 216 1340-4520 2023/04
• 内頸静脈アプローチで留置したCVポートにおけるカテーテル断裂のリスクファクターの検討

  上月 瞭平; 鶴崎 正勝; 浦瀬 篤史; 小寺 卓; 平山 歩; 石井 一成

  日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 224 - 224 1340-4520 2023/04
• Organ-Specific Positron Emission Tomography Scanners for Breast Imaging: Comparison between the Performances of Prior and Novel Models

  Yoko Satoh; Kohei Hanaoka; Chihiro Ikegawa; Masamichi Imai; Shota Watanabe; Daisuke Morimoto-Ishikawa; Hiroshi Onishi; Toshikazu Ito; Yoshifumi Komoike; Kazunari Ishii

  Diagnostics MDPI AG 13 (6) 1079 - 1079 2023/03 

  The performances of photomultiplier tube (PMT)-based dedicated breast positron emission tomography (PET) and silicon photomultiplier tube (SiPM)-based time-of-flight (TOF) PET, which is applicable not only to breast imaging but also to head imaging, were compared using a phantom study. A cylindrical phantom containing four spheres (3–10 mm in diameter) filled with 18F-FDG at two signal-to-background ratios (SBRs), 4:1 and 8:1, was scanned. The phantom images, which were reconstructed using three-dimensional list-mode dynamic row-action maximum likelihood algorithm with various β-values and post-smoothing filters, were visually and quantitatively compared. Visual evaluation showed that the 3 mm sphere was more clearly visualized with higher β and smaller post-filters, while the background was noisier; SiPM-based TOF-PET was superior to PMT-based dbPET in sharpness, smoothness, and detectability, although the background was noisier at the SBR of 8:1. Quantitative evaluation revealed that the detection index (DI) and recovery coefficient (CRC) of SiPM-based TOF-PET images were higher than those of PMT-based PET images, despite a higher background coefficient of variation (CVBG). The two organ-specific PET systems showed that a 3 mm lesion in the breast could be visualized at the center of the detector, and there was less noise in the SiPM-based TOF-PET image.
• Impact of respiratory gating and ECG gating on 18F-FDG PET/CT for cardiac sarcoidosis

  Kohei Hanaoka; Shota Watanabe; Daisuke Ishikawa; Hayato Kaida; Takahiro Yamada; Masakazu Yasuda; Yoshitaka Iwanaga; Gaku Nakazawa; Kazunari Ishii

  Journal of Nuclear Cardiology 30 (5) 1879 - 1885 2023/03 [Refereed]
   

  Background The aim of this study was to estimate the impact of respiratory and electrocardiogram (ECG)-gated FDG positron emission tomography (PET)/computed tomography (CT) on the diagnosis of cardiac sarcoidosis (CS). Methods and Results Imaging from thirty-one patients was acquired on a PET/CT scanner equipped with a respiratory- and ECG-gating system. Non-gated PET images and three kinds of gated PET/CT images were created from identical list-mode clinical PET data: respiratory-gated PET during expiration (EX), ECG-gated PET at end diastole (ED), and ECG-gated PET at end systole (ES). The maximum standardized uptake value (SUVmax) and cardiac metabolic volume (CMV) were measured, and the locations of FDG accumulation were analyzed using a polar map. The mean SUVmax of the subjects was significantly higher after application of either respiratory-gated or ECG-gated reconstruction. Conversely, the mean CMV was significantly lower following the application of respiratory-gated or ECG-gated reconstruction. The segment showing maximum accumulation was shifted to the adjacent segment in 25.8%, 38.7%, and 41.9% of cases in EX, ED, and ES images, respectively. Conclusion In FDG PET/CT scanning for the diagnosis of CS, gated scanning is likely to increase quantitative accuracy, but the effect depends on the location and synchronization method.
• 当院における急性上腸間膜動脈閉塞症に対するIVR治療経験

  浦瀬 篤史; 鶴崎 正勝; 小寺 卓; 上月 瞭平; 平山 歩; 石井 一成; 岩本 博司; 重岡 宏和

  日本腹部救急医学会雑誌 (一社)日本腹部救急医学会 43 (2) 408 - 408 1340-2242 2023/02
• High 18F-FDG Uptake in a Papillary Craniopharyngioma of the Third Ventricle

  Hayato Kaida; Yuko Matsukubo; Sung-Woon Im; Nobuo Kashiwagi; Kazunari Ishii

  Clinical Nuclear Medicine Ovid Technologies (Wolters Kluwer Health) Publish Ahead of Print 0363-9762 2023/01
• High-resolution silicon photomultiplier time-of-flight dedicated head PET system for clinical brain studies.

  Kazunari Ishii; Kohei Hanaoka; Shota Watanabe; Daisuke Morimoto-Ishikawa; Takahiro Yamada; Hayato Kaida; Yoshiyuki Yamakawa; Suzuka Minagawa; Shiho Takenouchi; Atsushi Ohtani; Tetsuro Mizuta

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2023/01 

  We acquired brain positron emission tomography (PET) images of fluorodeoxyglucose (FDG) and flutemetamol PET using a time-of-flight-PET system dedicated for the head (dhPET) and a conventional whole-body PET/computed tomography (wbPET) system and evaluated the clinical superiority of dhPET over wbPET. Methods: There were 18 subjects for the FDG-PET study and 17 subjects for the flutemetamol PET study. FDG-PET images were first obtained using wbPET, followed by dhPET. Flutemetamol PET images were first obtained using wbPET, followed by dhPET. Images acquired using dhPET and wbPET were compared by visual inspection, voxel-wise analysis, and standard uptake value ratio (SUVR). Results: All FDG and flutemetamol images acquired using dhPET were judged as better by visual inspection than those acquired using wbPET. The voxel-wise analysis demonstrated that accumulations in the cerebellum, lateral occipital cortices, and around the central sulcus area in dhPET FDG images were lower than those in wbPET FDG images, whereas accumulations around the ventricle systems were higher in dhPET FDG images than those in wbPET FDG images. Accumulations in the cerebellar dentate nucleus, midbrain, lateral occipital cortices, and around the central sulcus area in dhPET images were lower than those in wbPET images, whereas accumulations around the ventricle systems were higher in dhPET flutemetamol images than those in wbPET flutemetamol images. Mean cortical SUVRs of FDG and flutemetamol dhPET images were significantly higher than those of FDG and flutemetamol wbPET images, respectively. Conclusion: The dhPET images had better image quality by visual inspection and higher SUVRs than wbPET images. Although there were several regional accumulation differences between dhPET and wbPET images, understanding this phenomenon will enable full use of the features of this dhPET system in clinical practice.
• FlutemetamolアミロイドPETの中央読影における読影者間一致率の検討

  加藤 隆司; 納富 恵至; 小野 北斗; 石井 賢二; 石井 一成; 岩田 香織; 櫻井 圭太; 二橋 尚志; 中村 昭範; BATON Study Group

  核医学 (一社)日本核医学会 60 (Suppl.) S191 - S191 0022-7854 2023
• Asymmetric diffuse thyroid uptake on 18F-FDG PET/CT in patient with subacute thyroiditis: Case report and literature review.

  Hayato Kaida; Miyuki Wakana; Sawa Yoshida; Yuko Matsukubo; Kazunari Ishii

  Hellenic journal of nuclear medicine 26 (2) 150 - 154 2023 

  A 48-year-old man with an intermittent fever of 39.0oC for more than three weeks underwent computed tomography (CT) and blood testing, which revealed no clues. Antibiotics wereadministered, but his condition did not improve. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) showed right-lobe-dominant diffuse thyroid uptake. On technetium-99m (99mTc) pertechnetate scintigraphy, the thyroid gland could not be visualized, and he was diagnosed with subacute thyroiditis (SAT). When asymmetric 18F-FDG diffuse thyroid uptake on PET/CT is observed in a patient with a fever of unknown origin (FUO), SAT may need to be considered.
• [[PET] 2. Dedicated Breast PET System].

  Kohei Hanaoka; Shota Watanabe; Daisuke Ishikawa; Kazunari Ishii

  Nihon Hoshasen Gijutsu Gakkai zasshi 79 (1) 90 - 96 2023
• Visualization of tumor hypoxia and re-oxygenation after stereotactic body radiation therapy in early peripheral lung cancer: a prospective study.

  Inada M; Nishimura Y; Hanaoka K; Nakamatsu K; Doi H; Uehara T; Komanishi M; Ishii K; Kaida H; Hosono M

  Radiotherapy and Oncology In press 109491 - 109491 2023/01 [Refereed]
   

  BACKGROUND AND PURPOSE: In this study, fluoromisonidazole positron emission tomography (F-MISO PET/CT) was used to evaluate tumor hypoxia and re-oxygenation in patients with lung tumors treated with stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS: Patients with T1-2 N0 lung cancer were included in this study. The prescribed dose was 48-52 Gy in four fractions. F-MISO PET/CT was performed twice, before SBRT and 1-3 days after the first irradiation. The maximum standardized uptake value (SUVmax) and tumor/muscle ratio (TMR) were evaluated as indicators of hypoxia. The threshold for hypoxia was defined as a TMR of 1.30 or more. RESULTS: Between 2016 and 2021, 15 patients were included. Pre-treatment tumor hypoxia was observed in nine tumors (60 %). TMR in all six tumors without pre-treatment hypoxia rose after single high-dose irradiation. In contrast, TMR in six of nine tumors with pre-treatment hypoxia dropped after irradiation, suggesting re-oxygenation. Although no local recurrence was noted, regional and/or distant relapses were seen in four patients (27 %). Of these, three had tumors with abnormal F-MISO uptake. The remaining patient had a tumor without signs of hypoxia on pre-treatment PET/CT. The 2-year progression free survival of patients with tumors with and without pre-treatment hypoxia were 30 % and 63 %, respectively (p = 0.319). CONCLUSION: Tumor hypoxia reduced after single high-dose irradiation. Tumor with F-MISO uptake seems to be an unfavorable prognostic factor in lung SBRT.
• Evaluation of the performance of a high-resolution time-of-flight PET system dedicated to the head and breast according to NEMA NU 2-2012 standard.

  Daisuke Morimoto-Ishikawa; Kohei Hanaoka; Shota Watanabe; Takahiro Yamada; Yoshiyuki Yamakawa; Suzuka Minagawa; Shiho Takenouchi; Atsushi Ohtani; Tetsuro Mizuta; Hayato Kaida; Kazunari Ishii

  EJNMMI physics 9 (1) 88 - 88 2022/12 

  BACKGROUND: This study evaluated the physical performance of a positron emission tomography (PET) system dedicated to the head and breast according to the National Electrical Manufacturers Association (NEMA) NU2-2012 standard. METHODS: The spatial resolution, sensitivity, scatter fraction, count rate characteristics, corrections for count losses and randoms, and image quality of the system were determined. All measurements were performed according to the NEMA NU2-2012 acquisition protocols, but image quality was assessed using a brain-sized phantom. Furthermore, scans of the three-dimensional (3D) Hoffmann brain phantom and mini-Derenzo phantom were acquired to allow visual evaluation of the imaging performance for small structures. RESULTS: The tangential, radial, and axial full width at half maximum (FWHM) at a 10-mm offset in half the axial field of view were measured as 2.3, 2.5, and 2.9 mm, respectively. The average system sensitivity at the center of the field of view and at a 10-cm radial offset was 7.18 and 8.65 cps/kBq, respectively. The peak noise-equivalent counting rate was 35.2 kcps at 4.8 kBq/ml. The corresponding scatter fraction at the peak noise-equivalent counting rate was 46.8%. The peak true rate and scatter fraction at 8.6 kBq/ml were 127.8 kcps and 54.3%, respectively. The percent contrast value for a 10-mm sphere was approximately 50%. On the 3D Hoffman brain phantom image, the structures of the thin layers composing the phantom were visualized on the sagittal and coronal images. On the mini-Derenzo phantom, each of the 1.6-mm rods was clearly visualized. CONCLUSION: Taken together, these results indicate that the head- and breast-dedicated PET system has high resolution and is well suited for clinical PET imaging.
• Comparison of Conventional Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnostic Accuracy of Staging in Patients with Intrahepatic Cholangiocarcinoma.

  Eiko Nishioka; Masakatsu Tsurusaki; Ryohei Kozuki; Sung-Woon Im; Atsushi Kono; Kazuhiro Kitajima; Takamichi Murakami; Kazunari Ishii

  Diagnostics (Basel, Switzerland) 12 (11) 2022/11 

  We aimed to examine the accuracy of tumor staging of intrahepatic cholangiocarcinoma (ICC) by using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT). From January 2001 to December 2021, 202 patients underwent PET-CT, CT, and MRI for the initial staging of ICC in two institutions. Among them, 102 patients had undergone surgical treatment. Ninety patients who had a histopathological diagnosis of ICC were retrospectively reviewed. The sensitivity and specificity of 18F-FDG PET-CT, CT, and magnetic resonance imaging (MRI) in detecting tumors, satellite focus, vascular invasion, and lymph node metastases were analyzed. Ninety patients with histologically diagnosed ICC were included. PET-CT demonstrated no statistically significant advantage over CT and MR in the diagnosis of multiple tumors and macrovascular invasion, and bile duct invasion. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT in lymph node metastases were 84%, 86%, 91%, 84%, and 86%, respectively. PET-CT revealed a significantly higher accuracy compared to CT or MRI (86%, 67%, and 76%, p < 0.01, respectively) in the diagnosis of regional lymph node metastases. The accuracy of tumor staging by PET-CT was higher than that by CT/MRI (PET-CT vs. CT vs. MRI: 68/90 vs. 47/90 vs. 51/90, p < 0.05). 18F-FDG PET-CT had sensitivity and specificity values for diagnosing satellite focus and vascular and bile duct invasion similar to those of CT or MRI; however, PET-CT showed higher accuracy in diagnosing regional lymph node metastases. 18F-FDG PET-CT exhibited higher tumor staging accuracy than that of CT/MRI. Thus, 18FDG PET-CT may support tumor staging in ICC.
• The usefulness of the total metabolic tumor volume for predicting the postoperative recurrence of thoracic esophageal squamous cell carcinoma.

  Hayato Kaida; Takushi Yasuda; Osamu Shiraishi; Hiroaki Kato; Yutaka Kimura; Kohei Hanaoka; Minoru Yamada; Yuko Matsukubo; Masakatsu Tsurusaki; Kazuhiro Kitajima; Satoshi Hattori; Kazunari Ishii

  BMC cancer 22 (1) 1176 - 1176 2022/11 

  BACKGROUND: Induction or adjuvant therapies are not always beneficial for thoracic esophageal squamous cell carcinoma (ESCC) patients, and it is thus important to identify patients at high risk for postoperative ESCC recurrence. We investigated the usefulness of the total metabolic tumor volume (TMTV) for predicting the postoperative recurrence of thoracic ESCC. METHODS: We retrospectively analyzed the cases of 163 thoracic ESCC patients (135 men, 28 women; median age of 66 [range 34-82] years) treated at our hospital in 2007-2012. The TMTV was calculated from the fluorine-18 fluorodeoxyglucose (18F-FDG) uptake in the primary lesion and lymph node metastases. The optimal cut-off values for relapse and non-relapse were obtained by the time-dependent receiver operating curve analyses. Relapse-free survival (RFS) was evaluated by the Kaplan-Meier method, and between-subgroup differences in survival were analyzed by log-rank test. The prognostic significance of metabolic parameters and clinicopathological variables was assessed by a Cox proportional hazard regression analysis. The difference in the failure patterns after surgical resection was evaluated using the χ2-test. RESULTS: The optimal cut-off value of TMTV for discriminating relapse from non-relapse was 3.82. The patients with a TMTV ≥3.82 showed significantly worse prognoses than those with low values (p < 0.001). The TMTV was significantly related to RFS (model 1 for preoperative risk factors: TMTV: hazard ratio [HR] =2.574, p = 0.004; model 2 for preoperative and postoperative risk factors: HR = 1.989, p = 0.044). The combination of the TMTV and cN0-1 or pN0-1 stage significantly stratified the patients into low-and high-risk recurrence groups (TMTV cN0-1, p < 0.001; TMTV pN0-1, p = 0.004). The rates of hematogenous and regional lymph node metastasis were significantly higher in the patients with TMTV ≥3.82 than those with low values (hematogenous metastasis, p < 0.001, regional lymph node metastasis, p = 0.011). CONCLUSIONS: The TMTV was a more significantly independent prognostic factor for RFS than any other PET parameter in patients with resectable thoracic ESCC. The TMTV may be useful for the identifying thoracic ESCC patients at high risk for postoperative recurrence and for deciding the patient management.
• Pulmonary nodule volumetric accuracy of a deep learning-based reconstruction algorithm in low-dose computed tomography: A phantom study.

  Shota Watanabe; Kenta Sakaguchi; Shigetoshi Kitaguchi; Kazunari Ishii

  Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) ELSEVIER SCI LTD 104 1 - 9 1120-1797 2022/11 

  PURPOSE: To compare the image properties and pulmonary nodule volumetric accuracies among deep learning-based reconstruction (DLR), filtered back projection (FBP), and hybrid iterative reconstruction (hybrid IR) in low-dose computed tomography (LDCT). METHODS: A multipurpose chest phantom containing artificial spherical pulmonary nodules with 5-, 8-, 10-, and 12-mm diameters and Hounsfield units (HUs) of -630 and +100 HU was scanned 20 times at a standard dose, based on a low-dose screening CT trial, and at 1/2, 1/6, and 1/12 of the standard dose. To assess noise reduction performance and volumetric accuracy, the standard deviations (SDs) of the pixel values and volumetric percentage errors (PEs) were compared among FBP, hybrid IR, and DLR. The noise non-stationarity index (NNSI) was calculated from 20 image replicates and compared among FBP, hybrid IR, and DLR to evaluate noise stationarity. RESULTS: The SD reduction rates for FBP in hybrid IR and DLR were 62 %-85 % and 79 %-90 %, respectively. For the four nodules with +100 HU, the PE of all reconstruction methods was <±25 % (not clinically relevant). For the four nodules with -630 HU, the PEs were equivalent or lower for hybrid IR and DLR than for FBP, and the PE difference between hybrid IR and DLR ranged from 0 % to 7%. The NNSI was significantly higher for DLR than for FBP and hybrid IR (p < 0.01). CONCLUSIONS: Greater noise suppression was achieved with DLR than with hybrid IR without compromising nodule volumetric accuracy in LDCT despite the representative noise non-stationarity.
• Attenuation correction for phantom tests: an alternative to maximum-likelihood attenuation correction factor-based correction for clinical studies in time-of-flight PET.

  Tetsuro Mizuta; Yoshiyuki Yamakawa; Suzuka Minagawa; Tetsuya Kobayashi; Atsushi Ohtani; Shiho Takenouchi; Kohei Hanaoka; Shota Watanabe; Daisuke Morimoto-Ishikawa; Takahiro Yamada; Hayato Kaida; Kazunari Ishii

  Annals of nuclear medicine 36 (11) 998 - 1006 2022/11 

  OBJECTIVES: This study evaluates the phantom attenuation correction (PAC) method as an alternative to maximum-likelihood attenuation correction factor (ML-ACF) correction in time-of-flight (TOF) brain positron emission tomography (PET) studies. METHODS: In the PAC algorithm, a template emission image [Formula: see text] and a template attenuation coefficient image [Formula: see text] are prepared as a data set based on phantom geometry. Position-aligned attenuation coefficient image [Formula: see text] is derived by aligning [Formula: see text] using parameters that match the template emission image [Formula: see text] to measured emission image [Formula: see text]. Then, attenuation coefficient image [Formula: see text] combined with a headrest image is used for scatter and attenuation correction in the image reconstruction. To evaluate the PAC algorithm as an alternative to ML-ACF, Hoffman 3D brain and cylindrical phantoms were measured to obtain the image quality indexes of contrast and uniformity. These phantoms were also wrapped with a radioactive sheet to obtain attenuation coefficient images using ML-ACF. Emission images were reconstructed with attenuation correction by PAC and ML-ACF, and the results were compared using contrast and uniformity as well as visual assessment. CT attenuation correction (CT-AC) was also applied as a reference. RESULTS: The contrast obtained by ML-ACF was slightly overestimated due to its unique experimental condition for applying ML-ACF in Hoffman 3D brain phantom but the uniformity was almost equivalent among ML-ACF, CT-AC, and PAC. PAC showed reasonable result without overestimation compared to ML-ACF and CT-AC. CONCLUSIONS: PAC is an attenuation correction method that can ensure the performance in phantom test, and is considered to be a reasonable alternative to clinically used ML-ACF-based attenuation correction.
• Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age.

  Yosuke Hidaka; Mamoru Hashimoto; Takashi Suehiro; Ryuji Fukuhara; Tomohisa Ishikawa; Naoko Tsunoda; Asuka Koyama; Kazuki Honda; Yusuke Miyagawa; Kazuhiro Yoshiura; Shuken Boku; Kazunari Ishii; Manabu Ikeda; Minoru Takebayashi

  Fluids and barriers of the CNS 19 (1) 82 - 82 2022/10 

  BACKGROUND: Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes have not been well elucidated. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a neuroimaging phenotype of idiopathic normal-pressure hydrocephalus, originating from impaired CSF dynamics, and closely associated with aging. This study aimed to investigate the pathophysiology of DESH and determine age-related changes in CSF dynamics. METHODS: Using magnetic resonance imaging, we investigated the pathophysiology of DESH by quantitatively evaluating the volumes of DESH-related regions (ventricles [VS], Sylvian fissure [SF], and subarachnoid spaces at high convexity and midline [SHM]) and brain parenchyma in community-dwelling individuals aged  ≥ 65 years. DESH-related regions were assessed using a visual rating scale, and volumes measured using voxel-based morphometry. Brain parenchyma volumes were measured using FreeSurfer software. RESULTS: Data from 1,356 individuals were analyzed, and 25 (1.8%) individuals had DESH. Regarding the relationships between the volume of each CSF space and age, VS and SF volumes increased with age, whereas SHM volume did not increase. VS and SF volumes increased as the whole brain volume decreased, whereas SHM volume did not increase even if the whole brain volume decreased; that is, SHM did not expand even if brain atrophy progressed. Moreover, lower Mini-Mental State Examination scores were significantly associated with lower SHM volume and higher VS volume. These associations remained significant even when individuals with DESH were excluded. CONCLUSIONS: This study showed that the volume of high-convexity and medial subarachnoid spaces did not expand and tended to decrease with age; the human brain continuously progresses toward a "DESH-like" morphology with aging in community-dwelling older persons (i.e., DESH might be an "accelerated aging stage" rather than an "age-related disorder"). Our results indicated that brain atrophy may be associated with the development of "DESH-like" morphology. In addition, this morphological change, as well as brain atrophy, is an important condition associated with cognitive decline in older adults. Our findings highlight the importance of investigating the aging process of CSF dynamics in the human brain to preserve brain health in older people.
• MRI features of extraocular muscle metastases compared to those of other extraocular muscle diseases of non-thyroid origin

  Azusa Miura; Nobuo Kashiwagi; M. Sakai; Tomoko Hyodo; Hiroto Takahashi; Yumiko Miyauchi; Osamu Maenishi; Kazunari Ishii; Katsuyuki Nakanishi; Noriyuki Tomiyama

  Clinical Radiology 77 (12) 935 - 942 0009-9260 2022/10 [Refereed]
   

  Aim: To identify the magnetic resonance imaging (MRI) features of metastases to the extraocular muscles (EOM metastases). Material and methods: The MRI features of 19 patients with EOM metastases were compared with those of 24 patients with EOM diseases of non-thyroid origin. MRI was used to assess the number of tumours, morphology, signal intensity on T2-weighted images, enhancement patterns, and apparent diffusion coefficient (ADC) values. Results: Single muscular involvement was observed in 10 patients, and multiple muscular involvement was observed in nine patients. The morphology was focally discrete in nine patients, and diffuse infiltrative in 10 patients; all the nine patients with focal discrete morphology presented with single muscular lesions. On T2-weighted images, the signal intensities were intermediate or low in 15 patients and a mixture of high and intermediate in four patients. In 14 patients for whom contrast-enhanced images were available, ring enhancement (n=5), heterogeneous diffuse enhancement (n=5), and homogeneous enhancement (n=4) were seen. The mean ADC value was 0.98 × 10−3 mm2/s. Compared to other EOM diseases of non-thyroid origin, single muscular presentation, focal discrete morphology, the presence of hyperintensity on T2-weighted images, and ring or heterogeneous enhancement were significantly more frequent in EOM metastases. Conclusion: The MRI features of EOM metastases showed two main patterns: a single discrete mass and multiple infiltrative masses. In addition to the presentation as a single discrete mass, the presence of hyperintensity on T2-weighted images and ring or heterogeneous enhancement can aid in the differentiation of EOM metastases from other EOM diseases.
• Regional cerebral THK5351 accumulations correlate with neuropsychological test scores in Alzheimer continuum

  SungWoon Im; Kohei Hanaoka; Takahiro Yamada; Kazunari Ishii

  Asia Oceania Journal of Nuclear Medicine and Biology 2022/10 [Refereed]
   

  Objective: We evaluated the relationship between regional accumulations of the tau positron emission tomography (PET) tracer THK5351 and cognitive dysfunction in the Alzheimer's disease (AD) continuum. Methods: The cases of 18 patients with AD or mild cognitive impairment (MCI) due to AD who underwent three-dimensional MRI, fluoro-2-deoxyglucose (FDG)-(PET), Pittsburgh compound B (PiB)-amyloid PET, and THK5351-tau PET were analyzed. Their mean age was 70.6 ± 11.3, their mean Mini-Mental State Examination (MMSE) score was 22.3 ± 6.8, and their mean Alzheimer Disease Assessment Scale-Cognitive Subtest (ADAS) score was 12.5 ± 7.3. To determine the correlation between each patient's four imaging results and their MMSE and ADAS scores, we performed a voxel-wise statistical analysis with statistical parametric mapping (SPM). Results: The SPM analysis showed that the bilateral parietotemporal FDG accumulations and MMSE scores were positively correlated, and the bilateral parietotemporal FDG accumulations were negatively correlated with ADAS scores. There were significant correlations between bilateral parietotemporal and left posterior cingulate/precuneus THK5351 accumulations and MMSE/ADAS scores. Conclusion: In the AD brain, THK5351 correlates with neuropsychological test scores as well as or more additional than FDG due to its affinity for both tau and monoamine oxidase-B (MAO-B), and measurements of THK5351 may thus be useful in estimating the progression of AD.
• Automatic detection of primary and metastatic lesions on cervicothoracic region and whole-body bone using a uniform machine-learnable approach for [18F]-FDG-PET/CT image analysis.

  Mitsutaka Nemoto; Atsuko Tanaka; Hayato Kaida; Yuichi Kimura; Takashi Nagaoka; Takahiro Yamada; Kohei Hanaoka; Kazuhiro Kitajima; Tatsuya Tsuchitani; Kazunari Ishii

  Physics in medicine and biology 67 (19) 2022/09 

  We propose a method to detect primary and metastatic lesions with Fluorine-18 fluorodeoxyglucose (FDG) accumulation in the lung field, neck, mediastinum, and bony regions on the FDG-PET/CT images. To search for systemic lesions, various anatomical structures must be considered. The proposed method is addressed by using an extraction process for anatomical regions and a uniform lesion detection approach. The uniform approach does not utilize processes that reflect any region-specific anatomical aspects but has a machine-learnable framework. Therefore, it can work as a lesion detection process for a specific anatomical region if it machine-learns the specific region data. In this study, three lesion detection processes for the whole-body bone region, lung field, or neck-mediastinum region are obtained. These detection processes include lesion candidate detection and false positive (FP) candidate elimination. The lesion candidate detection is based on a voxel anomaly detection with a one-class support vector machine. The FP candidate elimination is performed using an AdaBoost classifier ensemble. The image features used by the ensemble are selected sequentially during training and are optimal for candidate classification. Three-fold cross-validation was used to detect performance with the 54 diseased FDG-PET/CT images. The mean sensitivity for detecting primary and metastatic lesions at 3 FPs per case was 0.89 with a 0.10 standard deviation (SD) in the bone region, 0.80 with a 0.10 SD in the lung field, and 0.87 with a 0.10 SD in the neck region. The average areas under the ROC curve were 0.887 with a 0.125 SD for detecting bone metastases, 0.900 with a 0.063 SD for detecting pulmonary lesions, and 0.927 with a 0.035 SD for detecting the neck-mediastinum lesions. These detection performances indicate that the proposed method could be applied clinically. These results also show that the uniform approach has high versatility for providing various lesion detection processes.
• Risk factors for unfavourable outcomes after shunt surgery in patients with idiopathic normal-pressure hydrocephalus

  Erena Kobayashi; Shigenori Kanno; Nobuko Kawakami; Wataru Narita; Makoto Saito; Keiko Endo; Masaki Iwasaki; Tomohiro Kawaguchi; Shigeki Yamada; Kazunari Ishii; Hiroaki Kazui; Masakazu Miyajima; Masatsune Ishikawa; Etsuro Mori; Teiji Tominaga; Fumiaki Tanaka; Kyoko Suzuki

  Scientific Reports Springer Science and Business Media LLC 12 (1) 13921 - 13921 2022/08 

  Abstract A number of vascular risk factors (VRFs) have been reported to be associated with idiopathic normal-pressure hydrocephalus (iNPH), but it remains unclear whether these VRFs are related to patient outcomes after shunt surgery. Therefore, we investigated the risk factors for unfavourable outcomes after shunt surgery in iNPH patients using two samples from Tohoku University Hospital and from a multicentre prospective trial of lumboperitoneal (LP) shunt surgery for patients with iNPH (SINPHONI-2). We enrolled 158 iNPH patients. We compared the prevalence of VRFs and clinical measures between patients with favourable and unfavourable outcomes and identified predictors of unfavourable outcomes using multivariate logistic regression analyses. The presence of hypertension, longer disease duration, more severe urinary dysfunction, and a lower Evans’ index were predictors of unfavourable outcomes after shunt surgery. In addition, hypertension and longer disease duration were also predictors in patients with independent walking, and a lower Evans’ index was the only predictor in patients who needed assistance to walk or could not walk. Our findings indicate that hypertension is the only VRF related to unfavourable outcomes after shunt surgery in iNPH patients. Larger-scale studies are needed to elucidate the reason why hypertension can affect the irreversibility of symptoms after shunt placement.
• 急性膵炎後のWONに対する画像診断および経皮的ドレナージの役割

  上月 瞭平; 鶴崎 正勝; 浦瀬 篤史; 小寺 卓; 平山 歩; 石井 一成; 大本 俊介; 竹中 完; 工藤 正俊

  日本医学放射線学会秋季臨床大会抄録集 (公社)日本医学放射線学会 58回 S439 - S440 0048-0428 2022/08
• Robustness of a U-net model for different image processing types in segmentation of the mammary gland region

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Hiroto Kimura; Takahiro Yamada; Mitsutaka Nemoto; Yuichi Kimura; Hisashi Handa; Hisashi Yoshida; Koji Abe; Masahiro Tada; Hitoshi Habe; Takashi Nagaoka; Seiun Nin; Kazunari Ishii; Yongbum Lee

  16th International Workshop on Breast Imaging (IWBI2022) SPIE 2022/07
• Utility of U-Net for the objective segmentation of the fibroglandular tissue region on clinical digital mammograms.

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Hiroto Kimura; Takahiro Yamada; Mitsutaka Nemoto; Yuichi Kimura; Hisashi Handa; Hisashi Yoshida; Koji Abe; Masahiro Tada; Hitoshi Habe; Takashi Nagaoka; Seiun Nin; Kazunari Ishii; Yohan Kondo

  Biomedical physics & engineering express IOP Publishing Ltd 8 (4) 2057-1976 2022/06 

  This study investigates the equivalence or compatibility between U-Net and visual segmentations of fibroglandular tissue regions by mammography experts for calculating the breast density and mean glandular dose (MGD). A total of 703 mediolateral oblique-view mammograms were used for segmentation. Two region types were set as the ground truth (determined visually): (1) one type included only the region where fibroglandular tissue was identifiable (called the 'dense region'); (2) the other type included the region where the fibroglandular tissue may have existed in the past, provided that apparent adipose-only parts, such as the retromammary space, are excluded (the 'diffuse region'). U-Net was trained to segment the fibroglandular tissue region with an adaptive moment estimation optimiser, five-fold cross-validated with 400 training and 100 validation mammograms, and tested with 203 mammograms. The breast density and MGD were calculated using the van Engeland and Dance formulas, respectively, and compared between U-Net and the ground truth with the Dice similarity coefficient and Bland-Altman analysis. Dice similarity coefficients between U-Net and the ground truth were 0.895 and 0.939 for the dense and diffuse regions, respectively. In the Bland-Altman analysis, no proportional or fixed errors were discovered in either the dense or diffuse region for breast density, whereas a slight proportional error was discovered in both regions for the MGD (the slopes of the regression lines were -0.0299 and -0.0443 for the dense and diffuse regions, respectively). Consequently, the U-Net and ground truth were deemed equivalent (interchangeable) for breast density and compatible (interchangeable following four simple arithmetic operations) for MGD. U-Net-based segmentation of the fibroglandular tissue region was satisfactory for both regions, providing reliable segmentation for breast density and MGD calculations. U-Net will be useful in developing a reliable individualised screening-mammography programme, instead of relying on the visual judgement of mammography experts.
• High 11C-Methionine Uptake in a Parasellar Inflammatory Pseudotumor.

  Hayato Kaida; Takeshi Okuda; Kohei Hanaoka; Kazunari Ishii

  Clinical nuclear medicine 47 (11) 965 - 967 2022/06 

  ABSTRACT: A 20-year-old man had left visual impairment and homonymous hemianopsia. MRI findings suggested enlargement of an optic glioma, because optic glioma was indicated by MRI 14 years earlier without a definite pathological diagnosis. 11C-methionine (MET) PET showed high uptake in the tumor in the parasellar region. Transnasal endoscopic biopsy was performed, and an inflammatory pseudotumor (IPT) was diagnosed based on histopathological findings. High MET uptake in a parasellar IPT has apparently not been previously reported. Clinicians should be aware of the possibility of high MET uptake in IPT, because this image could provide an interpretation pitfall.
• Comparison between the mu-maps of different PET tracers: 18F-FDG and 18F-flutemetamol, generated by the attenuation correction method without external radiation source

  Takahiro Yamada; Kohei Hanaoka; Yoshiyuki Yamakawa; Suzuka Minagawa; Atsushi Ohtani; Tetsuro Mizuta; Hayato Kaida; Kazunari Ishii

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 63 0161-5505 2022/06
• Comparison between gradient and spin-echo (GRASE) and compressed sensing sequences for single breath-hold three-dimensional magnetic resonance cholangiopancreatography in patients with T1 hyperintense bile.

  Daisuke Morimoto-Ishikawa; Tomoko Hyodo; Mamoru Takenaka; Yuko Matsukubo; Isao Numoto; Makoto Itoh; Masato Ohmi; Ken Kamata; Yu Ueda; Miyuki Wakana; Masatoshi Kudo; Shigeyoshi Saito; Kazunari Ishii

  European journal of radiology 150 110279 - 110279 2022/03 

  PURPOSE: To compare image quality and the detectability of gallstones in patients with T1 hyperintense bile between single breath-hold three-dimensional (3D) magnetic resonance cholangiopancreatography (MRCP) with gradient and spin-echo (GRASE) and with compressed sensing (CS). METHODS: We retrospectively evaluated patients who underwent MRCP using GRASE and CS and had hyperintense bile on T1-weighted fat-suppressed images. The relative duct-to-periductal contrast ratios (RCs) of each bile duct segment were calculated. Pancreaticobiliary duct visibility, motion artifacts, background suppression, and overall image quality were scored on a 5-point scale. The Wilcoxon signed-rank test was used to analyze differences in qualitative and quantitative results. Diagnostic performance in detecting common bile duct (CBD) and gallbladder stones was assessed using receiver operating characteristic (ROC) curves. RESULTS: In total, 96 patients were included in the study. RCs of all bile duct segments in GRASE MRCP were significantly lower than those in CS MRCP (p < 0.001). All biliary duct visibility and overall image quality had significantly higher scores in GRASE MRCP than in CS MRCP (p < 0.001-0.003). Area under ROC curves of GRASE MRCP and CS MRCP were 1.00 and 0.88 for CBD stone (p = 0.14) and 0.93 and 0.82 for gallbladder stone (p = 0.08), respectively. CONCLUSIONS: GRASE MRCP provides better image quality than CS MRCP in patients with hyperintense bile on T1-weighted images. The detectability of biliary stones was also higher in GRASE MRCP than in CS MRCP, although not significantly.
• Native T1マッピングによる潰瘍性大腸炎の疾患活動性評価の初期検討

  石川 大介; 兵頭 朋子; 米田 頼晃; 上田 優; 宮越 敬三; 齋藤 茂芳; 石井 一成

  日本放射線技術学会総会学術大会予稿集 (公社)日本放射線技術学会 78回 213 - 214 1884-7846 2022/03
• Initial evaluation of a new maximum-likelihood attenuation correction factor-based attenuation correction for time-of-flight brain PET.

  Tetsuro Mizuta; Tetsuya Kobayashi; Yoshiyuki Yamakawa; Kohei Hanaoka; Shota Watanabe; Daisuke Morimoto-Ishikawa; Takahiro Yamada; Hayato Kaida; Kazunari Ishii

  Annals of nuclear medicine 36 (4) 420 - 426 2022/02 

  AIM: The aim of this study was to evaluate an image reconstruction algorithm, including a new maximum-likelihood attenuation correction factor (ML-ACF) for time of flight (TOF) brain positron emission tomography (PET). METHODS: The implemented algorithm combines an ML-ACF method that simultaneously estimates both the emission image and attenuation sinogram from TOF emission data, and a scaling method based on anatomical features. To evaluate the algorithm's quantitative accuracy, three-dimensional brain phantom images were acquired and soft-tissue attenuation coefficients and emission values were analyzed. RESULTS: The heterogeneous distributions of attenuation coefficients in soft tissue, skull, and nasal cavity were sufficiently visualized. The attenuation coefficient of soft tissue remained within 5% of theoretical value. Attenuation-corrected emission showed no lateral differences, and significant differences among soft tissue were within the error range. CONCLUSION: The ML-ACF-based attenuation correction implemented for TOF brain PET worked well and obtained practical levels of accuracy.
• Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

  Takayuki Kondo; Norikazu Hara; Satoshi Koyama; Yuichiro Yada; Kayoko Tsukita; Ayako Nagahashi; Takeshi Ikeuchi; Kenji Ishii; Takashi Asada; Tetsuaki Arai; Ryo Yamada; Michael W. Weiner; Paul Aisen; Ronald Petersen; Clifford R. Jack; William Jagust; John Q. Trojanowki; Arthur W. Toga; Laurel Beckett; Robert C. Green; John Morris; Leslie M. Shaw; Jeffrey Kaye; Joseph Quinn; Lisa Silbert; Betty Lind; Raina Carter; Sara Dolen; Lon S. Schneider; Sonia Pawluczyk; Mauricio Beccera; Liberty Teodoro; Bryan M. Spann; James Brewer; Helen V; erswag; Adam Fleisher; Judith L. Heidebrink; Joanne L. Lord; Sara S. Mason; Colleen S. Albers; David Knopman; Kris Johnson; Rachelle S. Doody; Javier Villanueva-Meyer; Munir Chowdhury; Susan Rountree; Mimi Dang; Yaakov Stern; Lawrence S. Honig; Karen L. Bell; Beau Ances; John C. Morris; Maria Carroll; Mary L. Creech; Erin Franklin; Mark A. Mintun; Stacy Schneider; Angela Oliver; Daniel Marson; R; all Griffith; David Clark; David Geldmacher; John Brockington; Erik Roberson; Marissa Natelson Love; Hillel Grossman; Effie Mitsis; Raj C. Shah; Leyla deToledo-Morrell; Ranjan Duara; Daniel Varon; Maria T. Greig; Peggy Roberts; Marilyn Albert; Chiadi Onyike; Daniel D'Agostino; Stephanie Kielb; James E. Galvin; Brittany Cerbone; Christina A. Michel; Dana M. Pogorelec; Henry Rusinek; Mony J. de Leon; Lidia Glodzik; Susan De Santi; P. Murali Doraiswamy; Jeffrey R. Petrella; Salvador Borges-Neto; Terence Z. Wong; Edward Coleman; Charles D. Smith; Greg Jicha; Peter Hardy; Partha Sinha; Elizabeth Oates; Gary Conrad; Anton P. Porsteinsson; Bonnie S. Goldstein; Kim Martin; Kelly M. Makino; M. Saleem Ismail; Connie Br; Ruth A. Mulnard; Gaby Thai; Catherine Mc-Adams-Ortiz; Kyle Womack; Dana Mathews; Mary Quiceno; Allan I. Levey; James J. Lah; Janet S. Cellar; Jeffrey M. Burns; Russell H. Swerdlow; William M. Brooks; Liana Apostolova; Kathleen Tingus; Ellen Woo; Daniel H. S. Silverman; Po H. Lu; George Bartzokis; Neill R. Graff-Radford; Francine Parfitt; Tracy Kendall; Heather Johnson; Martin R. Farlow; Ann Marie Hake; Br; y R. Matthews; Jared R. Brosch; Scott Herring; Cynthia Hunt; Christopher H. van Dyck; Richard E. Carson; Martha G. MacAvoy; Pradeep Varma; Howard Chertkow; Howard Bergman; Chris Hosein; S; ra Black; Bojana Stefanovic; Curtis Caldwell; Ging-Yuek Robin Hsiung; Howard Feldman; Benita Mudge; Michele Assaly; Elizabeth Finger; Stephen Pasternack; Irina Rachisky; Dick Trost; Andrew Kertesz; Charles Bernick; Donna Munic; Marek Marsel Mesulam; Kristine Lipowski; S; ra Weintraub; Borna Bonakdarpour; Diana Kerwin; Chuang-Kuo Wu; Nancy Johnson; Carl Sadowsky; Teresa Villena; Raymond Scott Turner; Kathleen Johnson; Brigid Reynolds; Reisa A. Sperling; Keith A. Johnson; Gad Marshall; Jerome Yesavage; Joy L. Taylor; Barton Lane; Allyson Rosen; Jared Tinklenberg; Marwan N. Sabbagh; Christine M. Belden; S; ra A. Jacobson; Sherye A. Sirrel; Neil Kowall; Ronald Killiany; Andrew E. Budson; Alex; er Norbash; Patricia Lynn Johnson; Thomas O. Obisesan; Saba Wolday; Joanne Allard; Alan Lerner; Paula Ogrocki; Curtis Tatsuoka; Parianne Fatica; Evan Fletcher; Pauline Maillard; John Olichney; Charles DeCarli; Owen Carmichael; Smita Kittur; Michael Borrie; T.-Y. Lee; Rob Bartha; Sterling Johnson; Sanjay Asthana; Cynthia M. Carlsson; Steven G. Potkin; Adrian Preda; Dana Nguyen; Pierre Tariot; Anna Burke; Nadira Trncic; Adam Fleisher; Stephanie Reeder; Vernice Bates; Horacio Capote; Michelle Rainka; Douglas W. Scharre; Maria Kataki; Anahita Adeli; Earl A. Zimmerman; Dzintra Celmins; Alice D. Brown; Godfrey D. Pearlson; Karen Blank; Karen Anderson; Laura A. Flashman; Marc Seltzer; Mary L. Hynes; Robert B. Santulli; Kaycee M. Sink; Leslie Gordineer; Jeff D. Williamson; Pradeep Garg; Franklin Watkins; Brian R. Ott; Henry Querfurth; Geoffrey Tremont; Stephen Salloway; Paul Malloy; Stephen Correia; Howard J. Rosen; Bruce L. Miller; David Perry; Jacobo Mintzer; Kenneth Spicer; David Bachman; Nunzio Pomara; Raymundo Hern; o; Antero Sarrael; Norman Relkin; Gloria Chaing; Michael Lin; Lisa Ravdin; Am; a Smith; Balebail Ashok Raj; Kristin Fargher; Takeshi Iwatsubo; Takashi Asada; Hiroyuki Arai; Morihiro Sugishita; Hiroshi Matsuda; Kengo Ito; Michio Senda; Kenji Ishii; Ryozo Kuwano; Takeshi Ikeuchi; Noriko Sato; Hajime Sato; Shun Shimohama; Masaki Saitoh; Rika Yamauchi; Takashi Hayashi; Seiju Kobayashi; Norihito Nakano; Junichiro Kanazawa; Takeshi Ando; Chiyoko Takanami; Masato Hareyama; Masamitsu Hatakenaka; Eriko Tsukamoto; Shinji Ochi; Mikio Shoji; Etsuro Matsubara; Takeshi Kawarabayashi; Yasuhito Wakasaya; Takashi Nakata; Naoko Nakahata; Shuichi Ono; Yoshihiro Takai; Satoshi Takahashi; Hisashi Yonezawa; Junko Takahashi; Masako Kudoh; Makoto Sasaki; Yutaka Matsumura; Yohsuke Hirata; Tsuyoshi Metoki; Susumu Hayakawa; Yuichi Sato; Masayuki Takeda; Toshiaki Sasaki; Koichiro Sera; Kazunori Terasaki; Yoshihiro Saitoh; Shoko Goto; Kuniko Ueno; Hiromi Sakashita; Kuniko Watanabe; Ken Nagata; Yuichi Sato; Tetsuya Maeda; Yasushi Kondoh; Takashi Yamazaki; Daiki Takano; Mio Miyata; Hiromi Komatsu; Mayumi Watanabe; Tomomi Sinoda; Rena Muraoka; Kayoko Kikuchi; Hitomi Ito; Aki Sato; Toshibumi Kinoshita; Hideyo Toyoshima; Kaoru Sato; Shigeki Sugawara; Isao Ito; Fumiko Kumagai; Hiroyuki Arai; Katsutoshi Furukawa; Masaaki Waragai; Naoki Tomita; Nobuyuki Okamura; Mari Ootsuki; Katsumi Sugawara; Satomi Sugawara; Shunji Mugikura; Atsushi Umetsu; Takanori Murata; Tatsuo Nagasaka; Yukitsuka Kudo; Manabu Tashiro; Shoichi Watanuki; Masatoyo Nishizawa; Takeshi Ikeuchi; Takayoshi Tokutake; Saeri Ishikawa; Emiko Kishida; Nozomi Sato; Mieko Hagiwara; Kumi Yamanaka; Takeyuki Watanabe; Taeko Takasugi; Shoichi Inagawa; Kenichi Naito; Masanori Awaji; Tsutomu Kanazawa; Kouiti Okamoto; Masaki Ikeda; Tsuneo Yamazaki; Yuiti Tasiro; Syunn Nagamine; Shiori Katsuyama; Sathiko Kurose; Sayuri Fukushima; Etsuko Koya; Makoto Amanuma; Noboru Oriuti; Kouiti Ujita; Kazuhiro Kishi; Kazuhisa Tuda; Takashi Asada; Katsuyoshi Mizukami; Tetsuaki Arai; Etsuko Nakajima; Katsumi Miyamoto; Kousaku Saotome; Tomoya Kobayashi; Saori Itoya; Jun Ookubo; Toshiya Akatsu; Yoshiko Anzai; Junya Ikegaki; Yuuichi Katou; Kaori Kimura; Ryou Kuchii; Hajime Saitou; Kazuya Shinoda; Satoka Someya; Hiroko Taguchi; Kazuya Tashiro; Masaya Tanaka; Tatsuya Nemoto; Ryou Wakabayashi; Daisuke Watanabe; Harumasa Takano; Tetsuya Suhara; Hitoshi Shinoto; Hitoshi Shimada; Makoto Higuchi; Takaaki Mori; Hiroshi Ito; Takayuki Obata; Yoshiko Fukushima; Kazuko Suzuki; Izumi Izumida; Katsuyuki Tanimoto; Takahiro Shiraishi; Hitoshi Shinotoh; Hitoshi Shimada; Junko Shiba; Hiroaki Yano; Miki Satake; Aimi Nakui; Yae Ebihara; Tomomi Hasegawa; Yasumasa Yoshiyama; Mami Kato; Yuki Ogata; Hiroyuki Fujikawa; Nobuo Araki; Yoshihiko Nakazato; Takahiro Sasaki; Tomokazu Shimadu; Kimiko Yoshimaru; Hiroshi Matsuda; Etsuko Imabayashi; Asako Yasuda; Etuko Yamamoto; Natsumi Nakamata; Noriko Miyauchi; Keiko Ozawa; Rieko Hashimoto; Taishi Unezawa; Takafumi Ichikawa; Hiroki Hayashi; Masakazu Yamagishi; Tunemichi Mihara; Masaya Hirano; Shinichi Watanabe; Junichiro Fukuhara; Hajime Matsudo; Nobuyuki Saito; Atsushi Iwata; Hisatomo Kowa; Toshihiro Hayashi; Ryoko Ihara; Toji Miyagawa; Mizuho Yoshida; Yuri Koide; Eriko Samura; Kurumi Fujii; Kaori Watanabe; Nagae Orihara; Toshimitsu Momose; Akira Kunimatsu; Harushi Mori; Miwako Takahashi; Takuya Arai; Yoshiki Kojima; Masami Goto; Takeo Sarashina; Syuichi Uzuki; Seiji Katou; Yoshiharu Sekine; Yukihiro Takauchi; Chiine Kagami; Kazutomi Kanemaru; Shigeo Murayama; Yasushi Nishina; Kenji Ishii; Maria Sakaibara; Yumiko Okazaki; Rieko Okada; Maki Obata; Yuko Iwata; Mizuho Minami; Yasuko Hanabusa; Hanae Shingyouji; Kyoko Tottori; Aya Tokumaru; Makoto Ichinose; Kazuya Kume; Syunsuke Kahashi; Kunimasa Arima; Tadashi Tukamoto; Shin Tanaka; Yuko Nagahusa; Masuhiro Sakata; Mitsutoshi Okazaki; Yuko Saito; Maki Yamada; Tiine Kodama; Maki Obata; Tomoko Takeuchi; Keiichiro Ozawa; Yuko Iwata; Hanae Shingyouji; Yasuko Hanabusa; Yoshiko Kawaji; Kyouko Tottori; Noriko Sato; Yasuhiro Nakata; Satoshi Sawada; Makoto Mimatsu; Daisuke Nakkamura; Takeshi Tamaru; Shunichirou Horiuchi; Heii Arai; Tsuneyoshi Ota; Aiko Kodaka; Yuko Tagata; Tomoko Nakada; Eizo Iseki; Kiyoshi Sato; Hiroshige Fujishiro; Norio Murayama; Masaru Suzuki; Satoshi Kimura; Masanobu Takahashi; Haruo Hanyu; Hirofumi Sakurai; Takahiko Umahara; Hidekazu Kanetaka; Kaori Arashino; Mikako Murakami; Ai Kito; Seiko Miyagi; Kaori Doi; Kazuyoshi Sasaki; Mineo Yamazaki; Akiko Ishiwata; Yasushi Arai; Akane Nogami; Sumiko Fukuda; Kyouko Tottori; Mizuho Minami; Yuko Iwata; Koichi Kozaki; Yukiko Yamada; Sayaka Kimura; Ayako Machida; Kuninori Kobayashi; Hidehiro Mizusawa; Nobuo Sanjo; Mutsufusa Watanabe; Takuya Ohkubo; Hiromi Utashiro; Yukiko Matsumoto; Kumiko Hagiya; Yoshiko Miyama; Takako Shinozaki; Haruko Hiraki; Hitoshi Shibuya; Isamu Ohashi; Akira Toriihara; Shinichi Ohtani; Toshifumi Matsui; Yu Hayasaka; Tomomi Toyama; Hideki Sakurai; Kumiko Sugiura; Hirofumi Taguchi; Shizuo Hatashita; Akari Imuta; Akiko Matsudo; Daichi Wakebe; Hideki Hayakawa; Mitsuhiro Ono; Takayoshi Ohara; Yukihiko Washimi; Yutaka Arahata; Akinori Takeda; Yoko Konagaya; Akiko Yamaoka; Masashi Tsujimoto; Hideyuki Hattori; Takashi Sakurai; Miura Hisayuki; Hidetoshi Endou; Syousuke Satake; Young Jae Hong; Katsunari Iwai; Kenji Yoshiyama; Masaki Suenaga; Sumiko Morita; Teruhiko Kachi; Kenji Toba; Rina Miura; Takiko Kawai; Ai Honda; Kengo Itou; Takashi Kato; Ken Fujiwara; Rikio Katou; Mariko Koyama; Naohiko Fukaya; Akira Tsuji; Hitomi Shimizu; Hiroyuki Fujisawa; Tomoko Nakazawa; Satoshi Koyama; Takanori Sakata; Masahito Yamada; Mitsuhiro Yoshita; Miharu Samuraki; Kenjiro Ono; Moeko Shinohara; Yuki Soshi; Kozue Niwa; Chiaki Doumoto; Mariko Hata; Miyuki Matsushita; Mai Tsukiyama; Nozomi Takeda; Sachiko Yonezawa; Ichiro Matsunari; Osamu Matsui; Fumiaki Ueda; Yasuji Ryu; Masanobu Sakamoto; Yasuomi Ouchi; Yasuomi Ouchi; Madoka Chita; Yumiko Fujita; Rika Majima; Hiromi Tsubota; Umeo Shirasawa; Masashi Sugimori; Wataru Ariya; Yuuzou Hagiwara; Yasuo Tanizaki; Hidenao Fukuyama; Ryosuke Takahashi; Hajime Takechi; Chihiro Namiki; Kengo Uemura; Takeshi Kihara; Hiroshi Yamauchi; Shizuko Tanaka-Urayama; Emiko Maeda; Natsu Saito; Shiho Satomi; Konomi Kabata; Shin-Ichi Urayama; Tomohisa Okada; Koichi Ishizu; Shigeto Kawase; Satoshi Fukumoto; Masanori Nakagawa; Takahiko Tokuda; Masaki Kondo; Fumitoshi Niwa; Toshiki Mizuno; Yoko Oishi; Mariko Yamazaki; Daisuke Yamaguchi; Kyoko Ito; Yoku Asano; Chizuru Hamaguchi; Kei Yamada; Chio Okuyama; Kentaro Akazawa; Shigenori Matsushima; Takamasa Matsuo; Toshiaki Nakagawa; Takeshi Nii; Takuji Nishida; Kuniaki Kiuchi; Masami Fukusumi; Hideyuki Watanabe; Toshiaki Taoka; Akihiro Nogi; Masatoshi Takeda; Toshihisa Tanaka; Naoyuki Sato; Hiroaki Kazui; Kenji Yoshiyama; Takashi Kudo; Masayasu Okochi; Takashi Morihara; Shinji Tagami; Noriyuki Hayashi; Masahiko Takaya; Tamiki Wada; Mikiko Yokokoji; Hiromichi Sugiyama; Daisuke Yamamoto; Shuko Takeda; Keiko Nomura; Mutsumi Tomioka; Eiichi Uchida; Yoshiyuki Ikeda; Mineto Murakami; Takami Miki; Hiroyuki Shimada; Suzuka Ataka; Motokatsu Kanemoto; Jun Takeuchi; Akitoshi Takeda; Rie Azuma; Yuki Iwamoto; Naomi Tagawa; Junko Masao; Yuka Matsumoto; Yuko Kikukawa; Hisako Fujii; Junko Matsumura; Susumu Shiomi; Joji Kawabe; Yoshihiro Shimonishi; Yukio Miki; Mitsuji Higashida; Tomohiro Sahara; Takashi Yamanaga; Shinichi Sakamoto; Hiroyuki Tsushima; Kiyoshi Maeda; Yasuji Yamamoto; Toshio Kawamata; Kazuo Sakai; Haruhiko Oda; Takashi Sakurai; Taichi Akisaki; Mizuho Adachi; Masako Kuranaga; Sachi Takegawa; Yoshihiko Tahara; Seishi Terada; Takeshi Ishihara; Hajime Honda; Osamu Yokota; Yuki Kishimoto; Naoya Takeda; Nao Imai; Mayumi Yabe; Kentaro Ida; Daigo Anami; Seiji Inoue; Toshi Matsushita; Reiko Wada; Shinsuke Hiramatsu; Hiromi Tonbara; Reiko Yamamoto; Kenji Nakashima; Kenji Wada-Isoe; Saori Yamasaki; Eijiro Yamashita; Yu Nakamura; Ichiro Ishikawa; Sonoko Danjo; Tomomi Shinohara; Miyuki Ueno; Yuka Kashimoto; Yoshihiro Nishiyama; Yuka Yamamoto; Narihide Kimura; Kazuo Ogawa; Yasuhiro Sasakawa; Takashi Ishimori; Yukito Maeda; Tatsuo Yamada; Shinji Ouma; Aika Fukuhara-Kaneumi; Nami Sakamoto; Rie Nagao; Kengo Yoshimitsu; Yasuo Kuwabara; Ryuji Nakamuta; Minoru Tanaka; Manabu Ikeda; Mamoru Hashimoto; Keiichirou Kaneda; Yuusuke Yatabe; Kazuki Honda; Naoko Ichimi; Fumi Akatuka; Mariko Morinaga; Miyako Noda; Mika Kitajima; Toshinori Hirai; Shinya Shiraishi; Naoji Amano; Shinsuke Washizuka; Toru Takahashi; Shin Inuzuka; Tetsuya Hagiwara; Nobuhiro Sugiyama; Yatsuka Okada; Tomomi Ogihara; Takehiko Yasaki; Minori Kitayama; Tomonori Owa; Akiko Ryokawa; Rie Takeuchi; Satoe Goto; Keiko Yamauchi; Mie Ito; Tomoki Kaneko; Hitoshi Ueda; Shuichi Ikeda; Masaki Takao; Ban Mihara; Hirofumi Kubo; Akiko Takano; Gou Yasui; Masami Akuzawa; Kaori Yamaguchi; Toshinari Odawara; Megumi Shimamura; Mikiko Sugiyama; Atsushi Watanabe; Naomi Oota; Shigeo Takebayashi; Yoshigazu Hayakawa; Mitsuhiro Idegawa; Noriko Toya; Kazunari Ishii; Haruhisa Inoue

  Nature Aging Springer Science and Business Media {LLC} 2 (2) 125 - 139 2662-8465 2022/02
• Correlation between noise pareidolia test scores for visual hallucinations and regional cerebral blood flow in dementia with Lewy bodies.

  Takashi Nakata; Kenichi Shimada; Akiko Iba; Haruhiko Oda; Akira Terashima; Yutaka Koide; Ryota Kawasaki; Takahiro Yamada; Kazunari Ishii

  Annals of nuclear medicine 36 (4) 384 - 392 2022/01 

  OBJECTIVE: This study aimed at investigating the correlation between recurrent visual hallucinations (VHs) and regional cerebral blood flow (rCBF) in patients with dementia with Lewy bodies (DLB). METHODS: In 147 DLB patients, the correlation between noise pareidolia scores and rCBF in brain perfusion single photon emission computed tomography (SPECT) was evaluated. The 147 subjects comprised 52 probable and 95 possible DLB patients, of whom 107 did not have visual hallucinations and 40 had visual hallucinations. Brain perfusion SPECT was then performed, and memory impairment was assessed using the Mini-Mental State Examination (MMSE), while the optical illusion "pareidolia" (the tendency to see a specific image in a random visual pattern) was evaluated using noise pareidolia test. The correlations between rCBF and MMSE or noise pareidolia scores were then analyzed. RESULTS: The rCBF and MMSE scores were positively correlated, and rCBF was correlated with MMSE scores in a region that was consistent with a previously reported memory-related site. There was no correlation between noise pareidolia scores and occipital CBF, but there were weak correlations between noise pareidolia scores and rCBF in the bilateral frontal lobes (Brodmann area [BA]8 and BA9), left cingulate cortex (BA31), and left angular and supramarginal gyri (BA39 and BA40) in DLB patients. CONCLUSION: Weak correlation was found between noise pareidolia scores and rCBF in several sites (BA8, BA9, BA31, BA39 and BA40) other than in occipital lobe. These findings suggest that DLB hallucinations may be manifested by more complex brain network disorders, rather than by primary visual cortex disorders alone.
• Effect of cognitive reserve on amnestic mild cognitive impairment due to Alzheimer's disease defined by fluorodeoxyglucose-positron emission tomography.

  Takashi Kato; Yukiko Nishita; Rei Otsuka; Yoshitaka Inui; Akinori Nakamura; Yasuyuki Kimura; Kengo Ito

  Frontiers in aging neuroscience 14 932906 - 932906 2022 

  This study aimed to investigate the effect of cognitive reserve (CR) on the rate of cognitive decline and cerebral glucose metabolism in amnestic mild cognitive impairment (MCI) using the Study on Diagnosis of Early Alzheimer's Disease-Japan (SEAD-J) dataset. The patients in SEAD-J underwent cognitive tests and fluorodeoxyglucose-positron emission tomography (FDG-PET). MCI to be studied was classified as amnestic MCI due to Alzheimer's disease (AD) with neurodegeneration. A total of 57 patients were visually interpreted as having an AD pattern (P1 pattern, Silverman's classification). The 57 individuals showing the P1 pattern were divided into a high-education group (years of school education ≥13, N = 18) and a low-education group (years of school education ≤12, N = 39). Voxel-based statistical parametric mapping revealed more severe hypometabolism in the high-education group than in the low-education group. Glucose metabolism in the hippocampus and temporoparietal area was inversely associated with the years of school education in the high- and low-education groups (N = 57). General linear mixed model analyses demonstrated that cognitive decline was more rapid in the high-education group during 3-year follow-up. These results suggest that the cerebral glucose metabolism is lower and cognitive function declines faster in patients with high CR of amnestic MCI due to AD defined by FDG-PET.
• Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid.

  Kensaku Kasuga; Masataka Kikuchi; Tamao Tsukie; Kazushi Suzuki; Ryoko Ihara; Atsushi Iwata; Norikazu Hara; Akinori Miyashita; Ryozo Kuwano; Takeshi Iwatsubo; Takeshi Ikeuchi

  BMJ neurology open 4 (2) e000321  2022 

  Background: The AT(N) classification was proposed for categorising individuals according to biomarkers. However, AT(N) profiles may vary depending on the markers chosen and the target population. Methods: We stratified 177 individuals who participated in the Japanese Alzheimer's Disease Neuroimaging Initiative by AT(N) classification according to cerebrospinal fluid (CSF) biomarkers. We compared the frequency of AT(N) profiles between the classification using total tau and neurofilament light chain (NfL) as N markers (AT(N)tau and AT(N)NfL). Baseline characteristics, and longitudinal biological and clinical changes were examined between AT(N) profiles. Results: We found that 9% of cognitively unimpaired subjects, 49% of subjects with mild cognitive impairment, and 61% of patients with Alzheimer's disease (AD) dementia had the biological AD profile (ie, A+T+) in the cohort. The frequency of AT(N) profiles substantially differed between the AT(N)tau and AT(N)NfL classifications. When we used t-tau as the N marker (AT(N)tau), those who had T- were more frequently assigned to (N)-, whereas those who had T+were more frequently assigned to (N)+ than when we used NfL as the N marker (AT(N)NfL). During a follow-up, the AD continuum group progressed clinically and biologically compared with the normal biomarker group in both the AT(N)tau and AT(N)NfL classifications. More frequent conversion to dementia was observed in the non-AD pathological change group in the AT(N)tau classification, but not in the AT(N)NfL classification. Conclusions: AT(N)tau and AT(N)NfL in CSF may capture different aspects of neurodegeneration and provide a different prognostic value. The AT(N) classification aids in understanding the AD continuum biology in various populations.
• A Deep Learning System to Diagnose COVID-19 Pneumonia Using Masked Lung CT Images to Avoid AI-generated COVID-19 Diagnoses that Include Data outside the Lungs

  Takashi Nagaoka; Takenori Kozuka; Takahiro Yamada; Hitoshi Habe; Mitsutaka Nemoto; Masahiro Tada; Koji Abe; Hisashi Handa; Hisashi Yoshida; Kazunari Ishii; Yuichi Kimura

  Advanced Biomedical Engineering Japanese Society for Medical and Biological Engineering 11 76 - 86 2022
• Spontaneous closure of non-cavernous sinus dural arteriovenous fistulas: A case series and systematic review of the literature.

  Nobuo Kashiwagi; Koichi Miyazaki; Hiroto Takahashi; Kiyoshi Tsuji; Masahiro Fujiwara; Atsuko Arisawa; Hajime Nakamura; Haruhiko Kishima; Kazunari Ishii; Noriyuki Tomiyama

  Journal of neuroradiology = Journal de neuroradiologie 49 (1) 94 - 100 2022/01 

  BACKGROUND AND PURPOSE: To report 9 new cases of non-cavernous sinus dural arteriovenous fistulas (NCS-DAVFs) that closed spontaneously and systematically review reports of other cases in the literature. MATERIAL AND METHODS: We performed a retrospective analysis of 9 cases from 2 institutions of NCS-DAVFs that closed spontaneously. Using PubMed and Scopus in accordance with the PRISMA guidelines, we systematically reviewed English language articles about NCS-DAVFs showing spontaneous closure. RESULTS: Review of the cases from 2 institutions identified 9 cases of NCS-DAVFs showing spontaneous closure in follow-up magnetic resonance angiography (MRA), and the systematic review of the literature yielded an additional 38 cases, which had been diagnosed by repeated arteriography. Collectively, the patients included 23 men and 24 women with a mean age of 54 years. The shunts were located in the transverse-sigmoid sinus in 24 cases (51%), anterior condylar confluence in 11, and other locations in 12. Based on the venous drainage pattern on arteriography, 27 cases (57%) were classified as low-risk NCS-DAVF (without cortical venous reflux) and 17 were classified as high-risk NCS-DAVF (with cortical venous reflux). Shunt closure was observed within 3 months in 17 cases (36%). Extrinsic predisposing factors for shunt closure were detected in 14 cases (30%). These included angiography in 7 cases, sinus recanalization in 4, development of sinus occlusion in 2, and sinus compression by a newly developed hematoma in 1. CONCLUSION: Spontaneous closures of NCS-DAVFs can occur for both high- and low-risk types. One-third of these closures occur within 3 months.
• Application of correlated component analysis to dynamic PET time-activity curves denoising.

  Paulus Kapundja Shigwedha; Takahiro Yamada; Kohei Hanaoka; Kazunari Ishii; Yuichi Kimura; Yutaka Fukuoka

  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2021 3680 - 3683 2021/11 

  Positron emission tomography (PET) is a physiological, non-invasive imaging technique, which forms an essential part of nuclear medicine. The data obtained in a PET scan represent the concentration of an administered radiotracer in tissues over time. Quantitative analysis of PET data makes possible the assessments of in-vivo physiological processes. The Logan graphical analysis (LGA) is one of the methods that are used for quantitative analysis of PET data. LGA transforms PET data into a simple linear relationship. The slope of the LGA linear relationship is a physiological quantity denoting receptor availability. This quantity is termed distribution volume ratio (DVR). LGA-based estimates of the DVR are negatively affected by the noise in PET data -leading to the DVR being underestimated. A number of approaches proposed to address this issue have been observed to reduce the bias at the cost precision. An alternative regression method, least-squares cubic (LSC), was recently applied to estimate the DVR in order to reduce the bias. LSC was observed to reduce the bias in the LGA-based estimates. However, slight increases were also observed in the variance of the LSC-based estimates. This calls for methods to act against the variance in the LSC-based estimates. In this study, an alternative method is applied for tTAC denoising. This method is referred to as correlated component analysis (CorrCA). CorrCA transform the data by searching for dimensions of maximum correlation. This technique is closely related to other well-known methods such as principal component analysis and independent component analysis. In this study, the data were denoised by CorrCA (to act against the variance in the estimate) and the DVR was estimated by LSC, which provides for minimal bias. The resulting method LSC-CorrCA, gave less-biased estimated with increased precision. This was observed for both simulation results as well as for clinical data, both for 11C Pittsburgh compound B. Simulation data revealed reduced variances in LCS-CorrCA-based estimates, and the clinical data showed improved contrast between gray and white matter regions.Clinical Relevance-Improved DVR estimates would ease the interpretation of medical images, which will in turn positively influence the clinical processes, from diagnosis to treatment and follow-ups.
• Prognostic factors for bone metastases from head and neck squamous cell carcinoma: A case series of 97 patients.

  Takahisa Sakisuka; Nobuo Kashiwagi; Hiroshi Doi; Hiroto Takahashi; Atsuko Arisawa; Chisato Matsuo; Yu Masuda; Hidenori Inohara; Kazuaki Sato; Hidetatsu Outani; Kazunari Ishii; Noriyuki Tomiyama

  Molecular and clinical oncology 15 (5) 246 - 246 2021/11 

  Although bone is the second-most frequent site of distant metastases of head and neck squamous cell carcinoma (HNSCC), variable prognostic factors in patients with bone metastases from HNSCC have not been fully investigated. The aim of the present study was to assess the prognostic factors affecting overall survival (OS) in these patients. The medical records of 97 patients at two institutions who developed bone metastases from HNSCC between January 2010 and December 2020 were retrospectively reviewed. A multivariate analysis using a Cox proportional hazards model was performed to identify potential clinical predictive factors for longer OS. The median OS was 7 months, and the 1- and 2-year OS rates for all patients were 35.4 and 19.2%, respectively. The independent predictive factors for longer OS were single bone metastasis, good performance status and administration of systemic chemotherapy. The median OS with each predictor was 10, 10 and 10.5 months, respectively. In a selected group of patients with these three factors, the OS was 14.5 months. In conclusion, single bone metastasis, a good performance status and systemic chemotherapy were independent predictors of longer OS in patients with HNSCC, but their contributions were limited.
• Deep learning-based Hounsfield unit value measurement method for bolus tracking images in cerebral computed tomography angiography.

  Shota Watanabe; Kenta Sakaguchi; Daisuke Murata; Kazunari Ishii

  Computers in biology and medicine PERGAMON-ELSEVIER SCIENCE LTD 137 104824 - 104824 0010-4825 2021/10 

  BACKGROUND: Patient movement during bolus tracking (BT) impairs the accuracy of Hounsfield unit (HU) measurements. This study assesses the accuracy of measuring HU values in the internal carotid artery (ICA) using an original deep learning (DL)-based method as compared with using the conventional region of interest (ROI) setting method. METHOD: A total of 722 BT images of 127 patients who underwent cerebral computed tomography angiography were selected retrospectively and divided into groups for training data, validation data, and test data. To segment the ICA using our proposed method, DL was performed using a convolutional neural network. The HU values in the ICA were obtained using our DL-based method and the ROI setting method. The ROI setting was performed with and without correcting for patient body movement (corrected ROI and settled ROI). We compared the proposed DL-based method with settled ROI to evaluate HU value differences from the corrected ROI, based on whether or not patients experienced involuntary movement during BT image acquisition. RESULTS: Differences in HU values from the corrected ROI in the settled ROI and the proposed method were 23.8 ± 12.7 HU and 9.0 ± 6.4 HU in patients with body movement and 1.1 ± 1.6 HU and 3.9 ± 4.7 HU in patients without body movement, respectively. There were significant differences in both comparisons (P < 0.01). CONCLUSION: DL-based method can improve the accuracy of HU value measurements for ICA in BT images with patient involuntary movement.
• Deep learning-based Hounsfield unit value measurement method for bolus tracking images in cerebral computed tomography angiography.

  Shota Watanabe; Kenta Sakaguchi; Daisuke Murata; Kazunari Ishii

  Computers in biology and medicine 137 104824 - 104824 2021/09 

  BACKGROUND: Patient movement during bolus tracking (BT) impairs the accuracy of Hounsfield unit (HU) measurements. This study assesses the accuracy of measuring HU values in the internal carotid artery (ICA) using an original deep learning (DL)-based method as compared with using the conventional region of interest (ROI) setting method. METHOD: A total of 722 BT images of 127 patients who underwent cerebral computed tomography angiography were selected retrospectively and divided into groups for training data, validation data, and test data. To segment the ICA using our proposed method, DL was performed using a convolutional neural network. The HU values in the ICA were obtained using our DL-based method and the ROI setting method. The ROI setting was performed with and without correcting for patient body movement (corrected ROI and settled ROI). We compared the proposed DL-based method with settled ROI to evaluate HU value differences from the corrected ROI, based on whether or not patients experienced involuntary movement during BT image acquisition. RESULTS: Differences in HU values from the corrected ROI in the settled ROI and the proposed method were 23.8 ± 12.7 HU and 9.0 ± 6.4 HU in patients with body movement and 1.1 ± 1.6 HU and 3.9 ± 4.7 HU in patients without body movement, respectively. There were significant differences in both comparisons (P < 0.01). CONCLUSION: DL-based method can improve the accuracy of HU value measurements for ICA in BT images with patient involuntary movement.
• Lung carcinoma-associated cognitive impairment in a patient with Alzheimer's disease pathology: A case report.

  Kiyoto Takigawa; Masahiko Takaya; Kazunari Ishii; Kazumasa Saigoh; Osamu Shirakawa

  Clinical case reports 9 (7) e04482  2021/07 

  A patient with Alzheimer's disease (AD) pathology when cognitive impairment is detected tends to be diagnosed with AD. However, before diagnosing, we make an effort to exclude other diseases, for example, carcinoma.
• Longitudinal study of primary progressive aphasia in a patient with pathologically diagnosed Alzheimer's disease: a case report.

  Masahiko Takaya; Kazunari Ishii; Kazumasa Saigoh; Osamu Shirakawa

  Journal of medical case reports 15 (1) 272 - 272 2021/05 

  BACKGROUND: Alzheimer's disease is a neurodegenerative disease involving the deposition of pathologic amyloid-β and tau protein in the cerebral cortex. Alzheimer's disease is commonly characterized by progressive impairment of recent memory. Primary progressive aphasia is also often observed in patients with Alzheimer's disease. Moreover, language-associated symptoms, such as primary progressive aphasia, are diverse and varied in Alzheimer's disease. However, nonfluent/agrammatic variant primary progressive aphasia is not generally considered a symptom of Alzheimer's disease. To date, there has been no longitudinal study of primary progressive aphasia in Japanese-speaking patients or in patients speaking other languages with pathologically diagnosed Alzheimer's disease. Here we present a longitudinal study of primary progressive aphasia in a Japanese patient pathologically diagnosed with Alzheimer's disease. CASE PRESENTATION: A 75-year-old Japanese man, whose wife reported that his memory was impaired, also suffered from suspected aphasia. He was pathologically diagnosed with Alzheimer's disease using 11C-Pittsburgh compound-B positron emission tomography and 18F-THK5351 positron emission tomography. Based on clinical observation and the results of the Japanese standard language test of aphasia, he was also diagnosed with nonfluent/agrammatic variant primary progressive aphasia. During the subsequent 2 years, his cognitive impairment, aphasia, and behavioral and psychological symptoms of dementia progressed. Furthermore, progression of pathologic amyloid-β and tau protein deposition was revealed through 11C-Pittsburgh compound-B positron emission tomography and 18F-THK5351 positron emission tomography. Although the results of [123I] iodoamphetamine single-photon emission computed tomography suggested corticobasal degeneration, this was not observed on the [123I] FP-CIT single-photon emission computed tomography (SPECT) (DaTscan). A previous study had reported that Alzheimer's disease with a nonfluent/agrammatic variant primary progressive aphasia was accompanied by corticobasal degeneration; however, this was not true in our case. CONCLUSIONS: This is possibly the first longitudinal study of nonfluent/agrammatic variant primary progressive aphasia in a Japanese-speaking patient with pathologically diagnosed Alzheimer's disease, but without corticobasal degeneration.
• Relationship between F-18 florbetapir uptake in occipital lobe and neurocognitive performance in Alzheimer's disease.

  Tanyaluck Thientunyakit; Thonnapong Thongpraparn; Chakmeedaj Sethanandha; Takahiro Yamada; Yuichi Kimura; Weerasak Muangpaisan; Kazunari Ishii

  Japanese journal of radiology 39 (10) 984 - 993 2021/05 

  PURPOSE: To determine the association between occipital amyloid-PET uptake and neurocognitive performance in Alzheimer's disease (AD). MATERIALS AND METHODS: Fifty-eight participants with normal aged, mild cognitive impairment (MCI) due to AD and AD subjects who underwent F-18 florbetapir brain PET/CT scans were divided into four groups (A, normal; B, MCI; C, mild AD; and D, moderate/severe AD). Semiquantitative analyses of SUVR images were performed. The differences between groups and the correlations between florbetapir uptake and Thai Mental State Examination (TMSE) scores were determined. Significant differences were defined using a P < 0.001, uncorrected, or a P < 0.05, FWE for the voxel-based analyses with Statistical Parametric Mapping (SPM). RESULTS: There was a slightly higher florbetapir uptake in the precuneus, parietal, and occipital association cortices in Group B > A. The occipital florbetapir uptake in Groups C and D was significantly higher than in Group A, in addition to the precuneus, anterior cingulate, posterior cingulate, temporoparietal, and frontal cortices. There was a strong negative correlation between TMSE scores and florbetapir uptake in the occipital lobe. CONCLUSIONS: Occipital amyloid uptake is associated with clinically advanced AD, and is inversely correlated with neurocognitive performance and may be useful for evaluating AD severity.
• Predicting tumor response and prognosis to neoadjuvant chemotherapy in esophageal squamous cell carcinoma patients using PERCIST: a multicenter study in Japan.

  Hayato Kaida; Kazuhiro Kitajima; Masatoyo Nakajo; Mana Ishibashi; Tomoyuki Matsunaga; Ryogo Minamimoto; Kenji Hirata; Koya Nakatani; Ao Hung; Satoshi Hattori; Takushi Yasuda; Kazunari Ishii

  European journal of nuclear medicine and molecular imaging 48 (11) 3666 - 3682 2021/05 

  PURPOSE: To investigate the usefulness of the positron emission tomography response criteria in solid tumors 1.0 (PERCIST1.0) for predicting tumor response to neoadjuvant chemotherapy and prognosis and determine whether PERCIST improvements are necessary for esophageal squamous cell carcinoma (ESCC) patients. PATIENTS AND METHODS: We analyzed the cases of 177 ESCC patients and examined the association between PERCIST and their pathological responses. Associations of whole-PERCIST with progression-free survival (PFS) and overall survival (OS) were evaluated by a Kaplan-Meier analysis and Cox proportional hazards model. To investigate potential PERCIST improvements, we used the survival tree technique to understand patients' prognoses. RESULTS: There were significant correlations between the pathologic response and PERCIST of primary tumor (p < 0.001). The optimal cutoff value of the primary tumors' SULpeak response to classify pathologic responses was -50.0%. The diagnostic accuracy of SULpeak response was 87.3% sensitivity, 54.1% specificity, 68.9% accuracy, positive predictive value 60.5%, and negative predictive value 84.1%. Whole-PERCIST was significantly associated with PFS and OS. The survival tree results indicated that a high reduction of the whole SULpeak response was significantly correlated with the patients' prognoses. The cutoff values for the separation of prognoses were - 52.5 for PFS and - 47.1% for OS. CONCLUSION: PERCIST1.0 can help predict tumor responses and prognoses. However, 18F-FDG-PET/CT tends to underestimate residual tumors in histopathological response evaluations. Modified PERCIST, in which the partial metabolic response is further classified by the SULpeak response (-50%), might be more appropriate than PERCIST1.0 for evaluating tumor responses and stratifying high-risk patients for recurrence and poor prognosis.
• Primary diaphragmatic clear cell carcinoma associated with endometriosis: A case report and literature review.

  Mitsuru Matsuki; Isao Numoto; Takefumi Hamakawa; Kazunari Ishii; Takaaki Chikugo

  Gynecologic oncology reports 36 100733 - 100733 2021/05 

  Diaphragmatic endometriosis is extremely rare. Although endometriosis is considered generally benign, malignant transformation of endometriosis was reported in 1925. Multiple studies have since described clear cell carcinoma (CCC) or endometrioid carcinoma arising from ovarian endometriosis. Previously, only two reports of primary diaphragmatic CCC were reported, in which coexistent endometriosis with CCC was not histologically proven. We report a case of a 55-year-old postmenopausal woman who was admitted to Kindai university hospital for the examination of a cystic mass with papillary components in the right diaphragm. On her past medical history, abdominal hysterectomy and bilateral salpingo-oophorectomy was performed for high-grade cervical intraepithelial neoplasia, uterine myoma, and bilateral ovarian endometriosis 5 years ago. Unenhanced CT performed 5 years ago, showed a nodular lesion with low density in the right diaphragm, consistent with diaphragmatic endometriosis. Magnetic resonance imaging during this admission, showed a cystic mass with papillary components in the right diaphragm and a T2*-weighted gradient echo imaging showed partial low signal intensity in the papillary components and cyst wall, which was suspected to represent hemosiderin deposition. Based on these serial images, malignant transformation of diaphragmatic endometriosis was suspected. Under, open abdominal combined resection of the mass and part of the diaphragm was performed. Endometriosis implants were detected on the pelvic peritoneum. Histopathological examination revealed clear cell carcinoma associated with endometriosis and hemosiderin deposition in the cyst wall. T2*-weighted gradient echo imaging was useful in the detection of hemosiderin deposition caused by the coexistent endometriosis. When a cystic mass with papillary components and cyst wall with hemosiderin deposits are encountered on MR images, malignant transformation of endometriosis is suspected and a detailed medical history should be determined and the possibility of concurrent endometriosis or adenomyosis should be investigated, as should the potential existence of diaphragmatic endometriosis in previous images.
• Attenuation correction using deep learning for brain perfusion SPECT images.

  Kenta Sakaguchi; Hayato Kaida; Shuhei Yoshida; Kazunari Ishii

  Annals of nuclear medicine 35 (5) 589 - 599 2021/05 

  OBJECTIVE: Non-uniform attenuation correction using computed tomography (CT) improves the image quality and quantification of single-photon emission computed tomography (SPECT). However, it is not widely used because it requires a SPECT/CT scanner. This study constructs a convolutional neural network (CNN) to generate attenuation-corrected SPECT images directly from non-attenuation-corrected SPECT images. METHODS: We constructed an auto-encoder (AE) using a CNN to correct the attenuation in brain perfusion SPECT images. SPECT image datasets of 270 (44,528 slices including augmentation), 60 (5002 slices), and 30 (2558 slices) cases were used for training, validation, and testing, respectively. The acquired projection data were reconstructed in three patterns: uniform attenuation correction using Chang's method (Chang-AC), non-uniform attenuation correction using CT (CT-AC), and no attenuation correction (No-AC). The AE learned an end-to-end mapping between the No-AC and CT-AC images. The No-AC images in the test dataset were loaded into the trained AE, which generated images simulating the CT-AC images as output. The generated SPECT images were employed as attenuation-corrected images using the AE (AE-AC). The accuracy of the AE-AC images was evaluated in terms of the peak signal-to-noise ratio (PSNR) and the structural similarity metric (SSIM). The intensities of the AE-AC and CT-AC images were compared by voxel-by-voxel and region-by-region analysis. RESULTS: The PSNRs of the AE-AC and Chang-AC images, compared using CT-AC images, were 62.2, and 57.9, and their SSIM values were 0.9995 and 0.9985, respectively. The AE-AC and CT-AC images were visually and statistically in good agreement. CONCLUSIONS: The proposed AE-AC method yields highly accurate attenuation-corrected brain perfusion SPECT images.
• Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms.

  Ryuichi Takahashi; Kazunari Ishii; Kaoru Sousa; Kohei Marumoto; Tetsuo Kashibayashi; Jun Fujita; Kazumasa Yokoyama

  Journal of the neurological sciences 423 117363 - 117363 2021/04 

  PURPOSE: This study aimed to identify regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms, using dopamine transporter single-photon emission computed tomography images. MATERIAL AND METHODS: This study included 213 consecutive participants (Parkinson's disease [n = 111], dementia with Lewy bodies [n = 64], progressive supranuclear palsy with Richardson's syndrome [n = 18], and healthy participants [n = 20]) who underwent both magnetic resonance imaging and 123I-labelled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single-photon emission computed tomography/computed tomography. Using normalized specific binding ratio images, we created voxel-wise regional asymmetry index images to identify the regional specific pattern of regional asymmetries in degenerative parkinsonisms. RESULTS: Compared with healthy controls, patients with Parkinson's disease showed a regional asymmetry index increase in the nigrostriatal dopaminergic pathway, and those with dementia with Lewy bodies showed a regional asymmetry index increase confined to the bilateral caudate. Individuals with progressive supranuclear palsy exhibited a distinct regional asymmetry index increase in the pallido-subthalamic pathway. Notably, the regional asymmetry index increase in the subthalamic nucleus was significantly greater in progressive supranuclear palsy than in Parkinson's disease. CONCLUSION: The current study revealed distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms. The present findings highlight the potential application of visual diagnosis in degenerative parkinsonisms.
• Correction to: Predictive factors of truncation artifacts in the arterial phase of Gd-EOB-DTPA-enhanced MRI: a nationwide multicenter study.

  Masakatsu Tsurusaki; Keitaro Sofue; Hiromitsu Onishi; Satoshi Goshima; Atsushi Higaki; Hiroyoshi Isoda; Hiroki Haradome; Kazunari Ishii; Takamichi Murakami

  Japanese journal of radiology 39 (4) 405 - 405 2021/04
• Correction: Isao N., et al. Transcatheter Arterial Embolization Treatment for Bleeding Visceral Artery Pseudoaneurysms in Patients with Pancreatitis or Following Pancreatic Surgery. Cancers 2020, 12, 2733.

  Isao Numoto; Masakatsu Tsurusaki; Teruyoshi Oda; Yukinobu Yagyu; Kazunari Ishii; Takamichi Murakami

  Cancers 13 (6) 2021/03 

  The authors are sorry to report that the overall survival reported in their recently published paper was incorrect [...].
• Improving contrast between gray and white matter of Logan graphical analysis' parametric images in positron emission tomography through least-squares cubic regression and principal component analysis.

  Paulus Kapundja Shigwedha; Takahiro Yamada; Kohei Hanaoka; Kazunari Ishii; Yuichi Kimura; Yutaka Fukuoka

  Biomedical physics & engineering express 2021/03 

  Logan graphical analysis (LGA) is a method for in vivo quantification of tracer kinetics in positron emission tomography (PET). The shortcoming of LGA is the presence of a negative bias in the estimated parameters for noisy data. Various approaches have been proposed to address this issue. We recently applied an alternative regression method called least-squares cubic (LSC), which considers the errors in both the predictor and response variables to estimate the LGA slope. LSC reduced the bias in non-displaceable binding potential estimates while causing slight increases in the variance. In this study, we combined LSC with a principal component analysis (PCA) denoising technique to counteract the effects of variance on parametric image quality, which was assessed in terms of the contrast between gray and white matter. Tissue time-activity curves were denoised through PCA, prior to estimating the regression parameters using LSC. We refer to this approach as LSC-PCA. LSC-PCA was assessed against OLS-PCA (PCA with ordinary least-squares (OLS)), LSC, and conventional OLS-based LGA. Comparisons were made for simulated11C-carfentanil and11C Pittsburgh compound B (11C-PiB) data, and clinical11C-PiB PET images. PCA-based methods were compared over a range of principal components, varied by the percentage variance they account for in the data. The results showed reduced variances in distribution volume ratio estimates in the simulations for LSC-PCA compared to LSC, and lower bias compared to OLS-PCA and OLS. Contrasts were not significantly improved in clinical data, but they showed a significant improvement in simulation data |indicating a potential advantage of LSC-PCA over OLS-PCA. The effects of bias reintroduction when many principal components are used were also observed in OLS-PCA clinical images. We therefore encourage the use of LSC-PCA. LSC-PCA can allow the use of many principal components with minimal risk of bias, thereby strengthening the interpretation of PET parametric images.
• How to select training data to segment mammary gland region using a deep-learning approach for reliable individualized screening mammography

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Takahiro Yamada; Mitsutaka Nemoto; Yuichi Kimura; Hisashi Handa; Hisashi Yoshida; Koji Abe; Masahiro Tada; Hitoshi Habe; Takashi Nagaoka; Yoshiaki Ozaki; Seiun Nin; Kazunari Ishii; Yongbum Lee

  Medical Imaging 2021: Computer-Aided Diagnosis SPIE 11597 0277-786X 2021/02 

  In individualized screening mammography, a breast density is important to predict potential risks of breast cancer incidence and missing lesions in mammographic diagnosis. Segmentation of the mammary gland region is required when focusing on missing lesions. A deep-learning method was recently developed to segment the mammary gland region. A large amount of ground truth (prepared by mammary experts) is required for highly accurate deep-learning practice; however, this work is time- and labor-intensive. To streamline the ground truth in deep learning, we investigated a difference in acquired mammary gland regions among multiple radiological technologists having various experience and reading levels, who shared the criteria on segmentation. If we can ignore a skill level for image reading, we can increase a number of training images. Three certified radiological technologists segmented the mammary gland region in 195 mammograms. The degree of coincidence among them was assessed with respect to seven factors which indicated the feature of segmented regions including the breast density and mean glandular dose, using Student's t-test and Bland-Altman analysis. The assessments made by the three radiological technologists were consistent considering all factors, except the mean pixel value. Thus, we concluded that the ground truths prepared by multiple practitioners with different experiences can be accepted for the segmentation of the mammary gland region and they are applicable for training images if they stringently share the criteria on the segmentation.
• Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus.

  Madoka Nakajima; Shigeki Yamada; Masakazu Miyajima; Kazunari Ishii; Nagato Kuriyama; Hiroaki Kazui; Hideki Kanemoto; Takashi Suehiro; Kenji Yoshiyama; Masahiro Kameda; Yoshinaga Kajimoto; Mitsuhito Mase; Hisayuki Murai; Daisuke Kita; Teruo Kimura; Naoyuki Samejima; Takahiko Tokuda; Mitsunobu Kaijima; Chihiro Akiba; Kaito Kawamura; Masamichi Atsuchi; Yoshihumi Hirata; Mitsunori Matsumae; Makoto Sasaki; Fumio Yamashita; Shigeki Aoki; Ryusuke Irie; Hiroji Miyake; Takeo Kato; Etsuro Mori; Masatsune Ishikawa; Isao Date; Hajime Arai

  Neurologia medico-chirurgica 61 (2) 63 - 97 2021/02 

  Among the various disorders that manifest with gait disturbance, cognitive impairment, and urinary incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. The first edition of these guidelines for management of iNPH was published in 2004, and the second edition in 2012, to provide a series of timely, evidence-based recommendations related to iNPH. Since the last edition, clinical awareness of iNPH has risen dramatically, and clinical and basic research efforts on iNPH have increased significantly. This third edition of the guidelines was made to share these ideas with the international community and to promote international research on iNPH. The revision of the guidelines was undertaken by a multidisciplinary expert working group of the Japanese Society of Normal Pressure Hydrocephalus in conjunction with the Japanese Ministry of Health, Labour and Welfare research project. This revision proposes a new classification for NPH. The category of iNPH is clearly distinguished from NPH with congenital/developmental and acquired etiologies. Additionally, the essential role of disproportionately enlarged subarachnoid-space hydrocephalus (DESH) in the imaging diagnosis and decision for further management of iNPH is discussed in this edition. We created an algorithm for diagnosis and decision for shunt management. Diagnosis by biomarkers that distinguish prognosis has been also initiated. Therefore, diagnosis and treatment of iNPH have entered a new phase. We hope that this third edition of the guidelines will help patients, their families, and healthcare professionals involved in treating iNPH.
• Predictive factors of truncation artifacts in the arterial phase of Gd-EOB-DTPA-enhanced MRI: a nationwide multicenter study.

  Masakatsu Tsurusaki; Keitaro Sofue; Hiromitsu Onishi; Satoshi Goshima; Atsushi Higaki; Hiroyoshi Isoda; Hiroki Haradome; Kazunari Ishii; Takamichi Murakami

  Japanese journal of radiology 39 (2) 165 - 177 2021/02 

  PURPOSE: To identify predictive factors for truncation artifacts (TAs) in the arterial phase of Gd-EOB-DTPA-enhanced MRI in a multicenter study in Japan. MATERIALS AND METHODS: Data on patient factors (age, sex, weight, presence of viral hepatitis, and other conditions) and imaging parameters (e.g., triggering, voxel size, matrix, k-space ordering, acquisition time, reduction factor, flip angle, fat suppression, field strength, injection rate, and saline volume) were obtained. Univariate and multivariate analyses were performed to investigate the correlation of these parameters. RESULTS: We evaluated 1444 patients from 43 institutions who were scanned using GE, Siemens, Philips, or Toshiba MRI equipment (501, 354, 349, and 240 patients, respectively). The total incidence of TAs was 12.5% (17.2, 3.6, 15.7, and 12.1%, respectively). The matrix [odds ratio (OR) 0.13], flip angle (OR 5.77), use of fat suppression (OR 0.106), and field strength (OR 0.092) used in the Philips equipment significantly increased the incidence of TAs in MRI examination. CONCLUSIONS: The incidence of TAs in the arterial phase is influenced by several patient factors and imaging parameters. Especially, Siemens and Toshiba equipment had a significantly lower frequency of TAs. This indicates that such vendor-specific technology used in the dynamic sequence may have a TA-resistant effect.
• Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications.

  Masakatsu Tsurusaki; Keitaro Sofue; Masatoshi Hori; Kosuke Sasaki; Kazunari Ishii; Takamichi Murakami; Masatoshi Kudo

  Diagnostics (Basel, Switzerland) 11 (2) 2021/01 

  Dual-energy computed tomography (DECT) is an imaging technique based on data acquisition at two different energy settings. Recent advances in CT have allowed data acquisitions and simultaneous analyses of X-rays at two energy levels, and have resulted in novel developments in the field of abdominal imaging. The use of low and high X-ray tube voltages in DECT provide fused images that improve the detection of liver tumors owing to the higher contrast-to-noise ratio (CNR) of the tumor compared with the liver. The use of contrast agents in CT scanning improves image quality by enhancing the CNR and signal-to-noise ratio while reducing beam-hardening artifacts. DECT can improve detection and characterization of hepatic abnormalities, including mass lesions. The technique can also be used for the diagnosis of steatosis and iron overload. This article reviews and illustrates the different applications of DECT in liver imaging.
• Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I-III breast cancer: Multicenter study.

  Kazuhiro Kitajima; Yasuo Miyoshi; Tetsuro Sekine; Hiroyuki Takei; Kimiteru Ito; Akihiko Suto; Hayato Kaida; Kazunari Ishii; Hiromitsu Daisaki; Koichiro Yamakado

  Oncotarget 12 (2) 95 - 105 2021/01 

  OBJECTIVES: This study investigated harmonized pretreatment volume-based quantitative FDG-PET/CT parameters in breast cancer patients for prognostic value. RESULTS: During a median overall follow-up period of 5.3 years, 91 patients had recurrence and 40 died. Multivariate analysis of ER-positive/HER2-negative patients showed high maximum standardized uptake value (SUVmax) (p = 0.018), high total lesion glycolysis (TLG) (p = 0.010), and clinical N-classification (p = 0.0027) as independent negative predictors of RFS, while high maximum SUVmax (p = 0.037), advanced clinical T-classification (p = 0.030), and advanced TNM stage (p = 0.0067) were independent negative predictors of OS. For recurrence and death in HER2-positive patients, high total TLG (p = 0.037, p = 0.0048, respectively) and advanced TNM stage (p = 0.048, p = 0.046, respectively) were independent prediction factors. In the triple-negative group, independent factors related to recurrence and death were high maximum SUVmax (p = 0.0014, p = 0.0003, respectively) and advanced TNM stage (p < 0.0001, p < 0.0001, respectively). MATERIALS AND METHODS: Records of 546 stage I-III invasive breast cancer patients, including 344 estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 110 HER2-positive, and 92 triple-negative cases, treated at four institutions were reviewed retrospectively. Harmonized primary tumor and nodal maximum SUVmax, metabolic tumor volume (MTV), and TLG indicated in pretreatment FDG-PET/CT results were analyzed. Evaluations of relationships of clinicopathological factors, volume-based quantitative parameters, recurrence-free survival (RFS), and overall survival (OS) for each subtype were performed with a Cox proportional hazards model and log-rank test. CONCLUSIONS: The results indicated that potential surrogate markers for prognosis in patients with the three main subtypes of operable breast cancer include harmonized pretreatment quantitative volume-based FDG-PET/CT parameters, particularly whole-lesion SUVmax and TLG.
• Usefulness of respiratory-gated PET acquisition during delayed 18F-FDG PET/CT scanning for patients with liver metastases.

  Shota Watanabe; Kohei Hanaoka; Hayato Kaida; Tomoko Hyodo; Minoru Yamada; Masakatsu Tsurusaki; Kazunari Ishii

  Asia Oceania journal of nuclear medicine & biology 9 (2) 12 - 149 2021 

  Objectives: To assess respiratory-gated (RG) positron emission tomography (PET) acquisition for patients with liver metastases during delayed PET/computed tomography (CT) scanning with fluorine-18-fluorodeoxyglucose (18F-FDG). Methods: Nineteen patients with liver metastases who had undergone early whole-body 18F-FDG PET/CT scans without the RG technique and delayed scans with the RG technique were retrospectively selected. The maximum standardized uptake value (SUVmax) of 41 liver lesions and the tumor-to-liver uptake ratios (TLRs) for these same lesions were compared among three data sets: early non-respiratory-gated (early non-RG) images, delayed non-respiratory-gated (delayed non-RG) images, and delayed respiratory-gated (delayed RG) images. In the delayed non-RG and delayed RG images, the improvements in the TLR, relative to the early non-RG images, were assessed according to lesion size. Results: For liver lesions, the SUVmax of early non-RG, delayed non-RG, and delayed RG images were 6.58±2.34, 7.69±3.08, and 9.47±3.73, respectively. There were significant differences among the three images (P<0.01). The TLR of the delayed RG images was significantly higher than those of the early non-RG and delayed non-RG images (P<0.01). In the delayed RG images, the difference in the TLR improvement for lesions ≤10 mm in size was 15% higher than that for lesions >10 mm in size; in the delayed non-RG images, the difference in the TLR improvement for the same lesion categories was 6%. Conclusion: Delayed RG imaging improves the TLR, compared with early non-RG and delayed non-RG imaging, especially for small lesions. RG PET acquisition may be a promising protocol for assessing liver metastases on delayed PET/CT scans.
• The effect of breast density on the missed lesion rate in screening digital mammography determined using an adjustable-density breast phantom tailored to Japanese women.

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Yoshiaki Ozaki; Kazunari Ishii; Yongbum Lee

  PloS one PUBLIC LIBRARY SCIENCE 16 (1) e0245060  1932-6203 2021 

  OBJECTIVE: Despite the high risk of missing lesions in mammography, the missed lesion rate is yet to be clinically established. Further, no breast phantoms with adjustable breast density currently exist. We developed a novel, adjustable-density breast phantom with a composition identical to that of actual breasts, and determined the quantitative relationship between breast density and the missed lesion rate in mammography. METHODS: An original breast phantom consisting of adipose- and fibroglandular-equivalent materials was developed, and a receiver operating characteristic (ROC) study was performed. Breast density, which is the fraction by weight of fibroglandular to total tissue, was adjusted to 25%, 50%, and 75% by arbitrarily mixing the two materials. Microcalcification, mass lesions, and spiculated lesions, each with unique characteristics, were inserted into the phantom. For the above-mentioned fibroglandular densities, 50 positive and 50 negative images for each lesion type were used as case samples for the ROC study. Five certified radiological technologists participated in lesion detection. RESULTS: The mass-lesion detection rate, according to the area under the curve, decreased by 18.0% (p = 0.0001, 95% Confidence intervals [CI] = 0.1258 to 0.1822) and 37.8% (p = 0.0003, 95% CI = 0.2453 to 0.4031) for breast densities of 50% and 75%, respectively, compared to that for a 25% breast density. A similar tendency was observed with microcalcification; however, spiculated lesions did not follow this tendency. CONCLUSIONS: We quantified the missed lesion rate in different densities of breast tissue using a novel breast phantom, which is imperative for advancing individualized screening mammography.
• Regional gray matter-dedicated SUVR with 3D-MRI detects positive amyloid deposits in equivocal amyloid PET images.

  Kazunari Ishii; Takahiro Yamada; Kohei Hanaoka; Hayato Kaida; Koichi Miyazaki; Masami Ueda; Kazushi Hanada; Kazumasa Saigoh; Julia Sauerbeck; Axel Rominger; Peter Bartenstein; Yuichi Kimura

  Annals of nuclear medicine Springer Science and Business Media {LLC} 34 (11) 856 - 863 2020/11 [Refereed]
   

  PURPOSE: It is usually easy to judge whether amyloid PET images should be interpreted as positive or negative for amyloid deposits by visual inspection or quantitative measurement standard uptake value ratio (SUVR), but the findings are equivocal in some cases. As conventional mean cortical SUVR (mcSUVR) measures accumulation in both gray matter (GM) and white matter, it may mis-estimate amyloid deposits. The purpose of the study was to develop a regional GM-dedicated SUVR measuring (GMSUVR) system for amyloid PET images with 3D-MRI, and evaluate its utility for detecting amyloid deposits in equivocal cases. METHODS: Of 126 subjects who underwent amyloid PET with 11C-PiB and 3D-MRI, the area of amyloid-positive regions and the critical regional GMSUVR thresholds were first determined in 15 amyloid-positive and 15 amyloid-negative patients, using the automatic volumetric measurement of segmented brain images system. We then tested 36 amyloid-negative, 60 amyloid-positive, and 13 equivocal subjects with this GMSUVR system and with conventional mcSUVR. RESULTS: Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were 100%, 92%, 97%, 95%, and 100% for the GMSUVR system; and 97%, 86%, 93%, 92% and 94%, respectively, for mcSUVR. In 24 cases in which the findings were equivocal or discordant, the sensitivity, specificity, accuracy, PPV, and NPV were all 100% for the GMSUVR system; and were 90%, 33%, 83%, 90%, and 33%, respectively, for mcSUVR. CONCLUSION: The regional GMSUVR measurement method was well able to discriminate between amyloid-positive and -negative subjects, even in cases where amyloid deposition was equivocal.
• Efficiency of a computer-aided diagnosis (CAD) system with deep learning in detection of pulmonary nodules on 1-mm-thick images of computed tomography.

  Takenori Kozuka; Yuko Matsukubo; Tomoya Kadoba; Teruyoshi Oda; Ayako Suzuki; Tomoko Hyodo; SungWoon Im; Hayato Kaida; Yukinobu Yagyu; Masakatsu Tsurusaki; Mitsuru Matsuki; Kazunari Ishii

  Japanese journal of radiology Springer Science and Business Media LLC 38 (11) 1052 - 1061 1867-1071 2020/11 [Refereed]
   

  PURPOSE: To evaluate the performance of a deep learning-based computer-aided diagnosis (CAD) system at detecting pulmonary nodules on CT by comparing radiologists' readings with and without CAD. MATERIALS AND METHODS: A total of 120 chest CT images were randomly selected from patients with suspected lung cancer. The gold standard of nodules ≥ 3 mm was established by a panel of three expert radiologists. Two less experienced radiologists read the images without and afterward with CAD system. Their reading times were recorded. RESULTS: The radiologists' sensitivity increased from 20.9% to 38.0% with the introduction of CAD. The positive predictive value (PPV) decreased from 70.5% to 61.8%, and the F1-score increased from 32.2% to 47.0%. The sensitivity significantly increased from 13.7% to 32.4% for small nodules (3-6 mm) and from 33.3% to 47.6% for medium nodules (6-10 mm). CAD alone showed a sensitivity of 70.3%, a PPV of 57.9%, and an F1-score of 63.5%. Reading time decreased by 11.3% with the use of CAD. CONCLUSION: CAD improved the less experienced radiologists' sensitivity in detecting pulmonary nodules of all sizes, especially including a significant improvement in the detection of clinically important-sized medium nodules (6-10 mm) as well as small nodules (3-6 mm) and reduced their reading time.
• 食道癌の術前化学療法に対するFDG-PET/CTの有用性 多施設共同研究

  甲斐田 勇人; 北島 一宏; 中條 正豊; 石橋 愛; 南本 亮吾; 平田 健司; 中谷 航也; Ao Hung; 服部 聡; 安田 卓司; 石井 一成

  核医学 (一社)日本核医学会 57 (Suppl.) S144 - S144 0022-7854 2020/10
• アルツハイマー病疑い患者の18F-flutemetamol PETの定量評価

  松田 博史; 伊藤 健吾; 石井 一成; 下瀬川 恵久; 岡沢 秀彦; 三品 雅洋; 水村 直; 石井 賢二; 沖田 恭治; 重本 蓉子; 山尾 天翔

  核医学 (一社)日本核医学会 57 (Suppl.) S142 - S142 0022-7854 2020/10
• アルツハイマー病疑い患者の18F-flutemetamol PETの定量評価

  松田 博史; 伊藤 健吾; 石井 一成; 下瀬川 恵久; 岡沢 秀彦; 三品 雅洋; 水村 直; 石井 賢二; 沖田 恭治; 重本 蓉子; 山尾 天翔

  核医学 (一社)日本核医学会 57 (Suppl.) S142 - S142 0022-7854 2020/10
• Diagnostic utility of fusion 18F-fluorodeoxyglucose positron emission tomography/cardiac magnetic resonance imaging in cardiac sarcoidosis.

  Mana Okune; Masakazu Yasuda; Naoko Soejima; Yoshinori Kagioka; Kazuyoshi Kakehi; Takayuki Kawamura; Kohei Hanaoka; Hayato Kaida; Kazunari Ishii; Gaku Nakazawa; Shunichi Miyazaki; Yoshitaka Iwanaga

  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 29 (2) 753 - 764 2020/10 

  BACKGROUND: Although each 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE) has been used to diagnose cardiac sarcoidosis (CS), active CS is still misdiagnosed. METHODS: Active CS, diagnosed by PET alone, was defined as focal or focal on diffuse FDG uptake pattern. In fusion PET/CMR imaging, using a regional analysis with AHA 17-segment model, the patients were categorized into four groups: (1) PET-/LGE-, (2) PET+/LGE-, (3) PET+/LGE+, and (4) PET-/LGE+. PET+/LGE+ was defined as active CS. RESULTS: 74 Patients with suspected CS were enrolled. Between PET alone and fusion PET/CMR imaging, 20 cases had mismatch evaluations of active CS, and most had diffuse or focal on diffuse FDG uptake pattern on PET alone imaging. 40 Patients fulfilled the 2016 the Japanese Circulation Society diagnostic criteria for CS. The interobserver diagnostic agreement was excellent (κ statistics 0.89) and the overall accuracy for diagnosing CS was 87.8% in fusion PET/CMR imaging, which were superior to those in PET alone imaging (0.57 and 82.4%, respectively). In a sub-analysis of diffuse and focal on diffuse patterns, the agreement (κ statistics 0.86) and overall accuracy (81.8%) in fusion PET/CMR imaging were still better. CONCLUSIONS: Fusion PET/CMR imaging with regional analysis offered reliable and accurate diagnosis of CS, covering low diagnostic area by FDG-PET alone.
• Navigator-triggered and breath-hold 3D MRCP using compressed sensing: image quality and method selection factor assessment.

  Daisuke Morimoto; Tomoko Hyodo; Ken Kamata; Tomoya Kadoba; Makoto Itoh; Hiroyuki Fukushima; Yasutaka Chiba; Mamoru Takenaka; Tomohiro Mochizuki; Yu Ueda; Keizou Miyagoshi; Masatoshi Kudo; Kazunari Ishii

  Abdominal radiology (New York) 45 (10) 3081 - 3091 2366-004X 2020/10 [Refereed]
   

  PURPOSE: To examine whether MRCP using a combination of compressed sensing and sensitivity encoding with navigator-triggered and breath-hold techniques (NT C-SENSE and BH C-SENSE, respectively) have comparable image quality to that of navigator-triggered MRCP using only sensitivity encoding (NT SENSE) at 1.5-T. METHODS: Fifty-one participants were enrolled in this prospective study between July and October 2018 and underwent the three 3D MRCP sequences each. The acquisition time and relative duct-to-periductal contrast ratios (RC values) of each bile duct segment were obtained. Visualization of the bile and main pancreatic ducts, background suppression, artifacts, and overall image quality were scored on 5-point scales. Mean and median differences in RC values and qualitative scores of NT C-SENSE and BH C-SENSE relative to NT SENSE were calculated with 95% confidence intervals (CIs). RESULTS: Acquisition time of NT SENSE, NT C-SENSE, and BH C-SENSE were 348, 143 (mean for both), and 18 s (for all participants), respectively. The RC value of each bile duct segment was inferior, but the lower limits of the 95% CIs of the mean differences were ≥ - 0.10, for both NT C-SENSE and BH C-SENSE. The visualization score of the intrahepatic duct in BH C-SENSE was inferior to that in NT SENSE (lower 95% CI limit, - 1.5). In both NT C-SENSE and BH C-SENSE, the 95% CIs of the median differences in the other qualitative scores were from - 1.0 to 0.0. CONCLUSION: NT C-SENSE and BH C-SENSE have comparable image quality to NT SENSE at 1.5-T.
• Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases.

  Mitsuru Matsuki; Isao Numoto; Ayako Suzuki; Takefumi Hamakawa; Yuko Matsukubo; Masakatsu Tsurusaki; Kazunari Ishii; Tomoyuki Otani; Noriomi Matsumura

  Journal of computer assisted tomography 2020/09 

  OBJECTIVE: The aim of the study was to characterize magnetic resonance imaging findings in patients with recurrent ovarian adult granulosa cell tumors (AGCTs). METHODS: Clinical and magnetic resonance imaging manifestations of recurrent AGCTs were evaluated in 11 patients. RESULTS: Initial recurrences of AGCT were diagnosed between 13 months and 30 years (mean, 11.3 years). Recurrent tumors were located in the pelvic peritoneum, the abdominal peritoneum, the retroperitoneum, and bone. The number of recurrent tumors varied from 1 to 5. Tumors varied in morphology and all margins were well circumscribed. The internal structures noted were as follows: multilocular cystic and solid and cystic. Furthermore, internal hemorrhage and sponge-like multicystic components were identified. CONCLUSIONS: Ovarian AGCTs recurred in the pelvic peritoneum, abdominal peritoneum, and the retroperitoneal lymph nodes. Large recurrent AGCTs were commonly well circumscribed, round or lobulated, and multilocular cystic or solid and cystic. Moreover, they frequently included internal hemorrhage and sponge-like multicystic components.
• Transcatheter Arterial Embolization Treatment for Bleeding Visceral Artery Pseudoaneurysms in Patients with Pancreatitis or Following Pancreatic Surgery.

  Isao Numoto; Masakatsu Tsurusaki; Teruyoshi Oda; Yukinobu Yagyu; Kazunari Ishii; Takamichi Murakami

  Cancers {MDPI} {AG} 12 (10) 2733 - 2733 2020/09 [Refereed]
   

  PURPOSE: To evaluate the efficacy and safety of transcatheter arterial embolization (TAE) for pseudoaneurysms occurring secondary to pancreatitis or because of leakage of pancreatic juice after pancreatectomy. MATERIALS AND METHODS: This retrospective study included 42 consecutive patients (38 males and 4 females; mean age, 60 years; range, 33-80 years) who underwent TAE for bleeding visceral artery pseudoaneurysms between March 2004 and December 2018. The technical and clinical success rates, incidence of recurrent bleeding, complications, including pancreatitis, and overall survival after TAE were evaluated. RESULTS: Of the 42 enrolled patients, 23 had bleeding due to a complication of pancreatectomy and 19 had bleeding as a complication of pancreatitis. TAE with N-butyl cyanoacrylate (NBCA) or NBCA plus microcoils recurrent bleeding or inability to control bleeding was 15.8% (3 of 19) following TAE with NBCA and 17.4% (4 of 23) following TAE with coils. No clinically significant ischemic events of the pancreas or duodenum were observed in the embolized areas. Serum amylase did not increase compared with the initial levels after any of the procedures. At 30 days after TAE, 32 patients were alive. CONCLUSION: TAE has a high success rate for the management of hemorrhage, with few complications. The procedure appears to be safe and effective for pseudoaneurysms associated with either pancreatitis or pancreatectomy.
• Progressive amnestic cognitive impairment in a middle-aged patient with developmental language disorder: a case report.

  Masahiko Takaya; Kazunari Ishii; Kaori Kiguchi; Kazumasa Saigoh; Osamu Shirakawa

  Journal of medical case reports 14 (1) 139 - 139 2020/09 [Refereed]
   

  BACKGROUND: Developmental disorder and dementia in older adults have been considered unrelated clinical entities because their timing of diagnosis differs greatly; however, recent studies have suggested an association between them. This case describes a middle-aged patient with language disorder exhibiting progressive amnestic cognitive impairment. CASE PRESENTATION: A 44-year-old Japanese man with long-term language dysfunction presented for his first-ever medical evaluation at age 36 years. Although his conversational ability had been impaired since childhood, he was able to graduate from secondary school and gain unskilled employment. At age 36 years, however, his workplace environment became more stressful, which led to behavioral problems that necessitated medical consultation. He consulted two psychiatrists in vain. At age 44 years, the third attending psychiatrist examined him in detail. The major component of his language disorder was amnestic cognitive impairment in the language domain as shown by logical memory subtests of the Wechsler Memory Scale-Revised. Magnetic resonance imaging showed normal findings for his age and no small vessel disease. Global cerebral hypoperfusion versus cerebellar blood flow was shown on (123I) iodoamphetamine single-photon emission computed tomography, and amyloid-β deposition was negative on positron emission tomography with 11C-Pittsburgh compound B. Pathologic tau accumulation was negative on 18F-THK5351 positron emission tomography imaging. Laboratory tests show no infections, no vitamin deficiencies, and no other diseases that may cause dementia. Clinical features, results of neurocognitive tests and neuroimaging studies showed no well-known neurodegenerative diseases. Collectively, he was diagnosed with language disorder based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. Over a 2-year follow-up period, amnestic cognitive impairment in visual and language domains progressed in parallel with global cerebral hypoperfusion. CONCLUSION: This case suggests a possible link between language disorder as defined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and progressive amnestic cognitive impairment in middle age, which may ultimately lead to dementia, derived from a neurodegenerative disease.
• One-class SVMによる画素悪性度の集中性を用いたFDG-PET/CT上の病変自動検出

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 牛房 和之; 山田 誉大; 花岡 宏平; 北島 一宏; 槌谷 達也; 石井 一成

  日本医用画像工学会大会予稿集 日本医用画像工学会 39回 29 - 29 2020/09
• One-class SVMによる画素悪性度の集中性を用いたFDG-PET/CT上の病変自動検出

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 牛房 和之; 山田 誉大; 花岡 宏平; 北島 一宏; 槌谷 達也; 石井 一成

  日本医用画像工学会大会予稿集 日本医用画像工学会 39回 153 - 158 2020/09
• 【解剖と病態生理から迫る呼吸器画像診断】(第II章)サブマクロ解剖と病変の画像 肺既存構造との関係から考える肺結節の鑑別診断 胸膜,肺血管,気管支などの既存構造から肺結節の診断に迫る

  小塚 健倫; 石井 一成; 清水 重喜

  画像診断 (株)学研メディカル秀潤社 40 (11) A168 - A184 0285-0524 2020/09 

  ＜文献概要＞・肺のCTは,一見,広範な空間の中に,血管と気管支が樹木のように生い茂っているようにみえるかもしれない.しかし,実際は肝と同じように,葉という大きな区分と小葉という小さな区分の集合体である.・CTにはあまり描出されないが,肺には葉間裂や小葉間隔壁,肺胞隔壁などの多くの壁が存在している.ここに病変が発生すると,病変が,血管やこれらの壁で遮られるか,これらをゆがめるか,突破するか,あるいはすり抜けるかによって,病変の特徴をとらえることができる.
• WONのCT所見とステップアップアプローチ

  沼本 勲男; 鶴崎 正勝; 小田 晃義; 柳生 行伸; 石井 一成; 大本 俊介; 竹中 完; 工藤 正敏

  日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 35 (Suppl.) 205 - 205 1340-4520 2020/08
• Image quality comparison of a nonlinear image-based noise reduction technique with a hybrid-type iterative reconstruction for pediatric computed tomography

  Shota Watanabe; Katsuhiro Ichikawa; Hiroki Kawashima; Yuki Kono; Hiroyuki Kosaka; Koji Yamada; Kazunari Ishii

  PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS ELSEVIER SCI LTD 76 100 - 108 1120-1797 2020/08 [Refereed]
   

  Purpose: To compare computed tomography (CT) image properties between a vendor-independent image-based noise reduction technique, Image-space Noise Reduction (iNoir) and a hybrid-type iterative reconstruction technique, Adaptive Statistical Iterative Reconstruction (ASIR).Methods: A cylindrical water phantom, corresponding to pediatric body size, containing soft-tissue-equivalent rod and 12-mg iodine/ml rod was scanned at size-specific dose estimates of 8.4 and 16.7 mGy. For assessments of image quality and noise texture change, task-based system performance function (SPF) and peak frequency difference (PFD) were compared, respectively, among filtered back projection (FBP), IR image with 50%-blending rate (50%ASIR), 100%ASIR, 50%iNoir, and 100%iNoir. Human observer WA for pediatric CT images was performed by radiologists.Results: For the soft-tissue contrast, SPF2 of 100%iNoir was the highest. The average SPF2 between 0.1 and 0.5 cycles/mm for 100%iNoir increased by approximately 70% compared with FBP, while ASIR indicted slight increases in the frequency region of > 0.2 cycles/mm. For the iodine contrast, 100%iNoir indicated highest values at the spatial frequencies corresponding pediatric artery diameters. The PFDs of iNoir were negligible and lower than that of ASIR. The results of human observer WA supported results of SPF2 and PFD.Conclusions: Compared with ASIR, iNoir provided better image quality for pediatric abdominal CT without compromising noise texture change.
• AI approach of cycle-consistent generative adversarial networks to synthesize PET images to train computer-aided diagnosis algorithm for dementia.

  Yuichi Kimura; Aya Watanabe; Takahiro Yamada; Shogo Watanabe; Takashi Nagaoka; Mitsutaka Nemoto; Koichi Miyazaki; Kohei Hanaoka; Hayato Kaida; Kazunari Ishii

  Annals of nuclear medicine 34 (7) 512 - 515 2020/07 [Refereed]
   

  OBJECTIVE: An artificial intelligence (AI)-based algorithm typically requires a considerable amount of training data; however, few training images are available for dementia with Lewy bodies and frontotemporal lobar degeneration. Therefore, this study aims to present the potential of cycle-consistent generative adversarial networks (CycleGAN) to obtain enough number of training images for AI-based computer-aided diagnosis (CAD) algorithms for diagnosing dementia. METHODS: We trained CycleGAN using 43 amyloid-negative and 45 positive images in slice-by-slice. RESULTS: The CycleGAN can be used to synthesize reasonable amyloid-positive images, and the continuity of slices was preserved. DISCUSSION: Our results show that CycleGAN has the potential to generate a sufficient number of training images for CAD of dementia.
• Assessment of Liver Metastases Using CT and MRI Scans in Patients with Pancreatic Ductal Adenocarcinoma: Effects of Observer Experience on Diagnostic Accuracy.

  Masakatsu Tsurusaki; Isao Numoto; Teruyoshi Oda; Miyuki Wakana; Ayako Suzuki; Yukinobu Yagyu; Mitsuru Matsuki; Kazunari Ishii

  Cancers 12 (6) 2020/06 [Refereed]
   

  The aim of this study was to investigate the impact of radiologic experience on the diagnostic accuracy of computed tomography (CT) vs. magnetic resonance imaging (MRI) reporting on the liver metastases of pancreatic ductal adenocarcinoma (LM of PDAC). Intra-individual CT and MRI examinations of 112 patients with clinically proven LM of PDAC were included. Four radiologists with varying years of experience (A > 20, B > 5, C > 1 and D < 1) assessed liver segments affected by LM of PDAC, as well as associated metastases occurring in each patient. Their sensitivity and specificity in evaluating the segments were compared. Cohen's Kappa (κ) for diagnosed liver segments and Intra-class Correlation Coefficients (ICC) for the number of metastatic lesions in each patient were calculated. The radiologists' sensitivity and specificity for the CT vs. MRI were, respectively: Reader A-94.4%, 90.3% vs. 96.6%, 94.8%; B-86.7%, 79.7% vs. 83.9%, 82.0%; C-78.0%, 76.7% vs. 83.3%, 78.9% and D-71.8%, 79.2% vs. 64.0%, 69.5%. Reviewers A and B achieved greater agreement in assessing results from the MRI (κ = 0.72, p < 0.001; ICC = 0.73, p < 0.001) vs. the CT (κ = 0.58, p < 0.001; ICC = 0.61, p < 0.001), in contrast to readers C and D (MRI: κ = 0.34, p < 0.001; ICC = 0.42, p < 0.001, and CT: κ = 0.48, p < 0.001; ICC = 0.59, p < 0.001). Our results indicate that the accurate diagnosis of LM of PDAC depends more on radiologic experience in MRI over CT scans.
• 18F-FDG PET/CT Finding of Primary Cardiac Lymphoma.

  Hayato Kaida; Takahiro Kumode; Masatomo Kimura; Kazunari Ishii

  Clinical nuclear medicine 45 (4) 319 - 321 2020/04 [Refereed]
   

  An 80-year-old woman experienced dyspnea. Cardiac enlargement was detected by chest radiography at a local hospital. She was admitted to our hospital, and echocardiography and CT revealed pericardial effusion and multiple tumor lesions in right atrium. F-FDG PET/CT demonstrated multiple nodular accumulations in these tumors (SUVmax, 14.5). Cytologic analysis of the pericardial fluid revealed a diffuse large B-cell lymphoma. Primary cardiac lymphoma (PCL) is rare, and there are few reports about the F-FDG PET/CT imaging features of PCLs. In high F-FDG uptake in multiple tumors in the right atrium and large pericardial effusion, a PCL should be considered.
• Patterns of bone metastases from head and neck squamous cell carcinoma.

  Ayako Suzuki; Nobuo Kashiwagi; Hiroshi Doi; Kazunari Ishii; Katsumi Doi; Mutsukazu Kitano; Takenori Kozuka; Tomoko Hyodo; Masakatsu Tsurusaki; Yukinobu Yagyu; Katsuyuki Nakanishi

  Auris, nasus, larynx 47 (2) 262 - 267 0385-8146 2020/04 [Refereed]
   

  OBJECTIVE: To report clinical features of bone metastases (BM) from head and neck squamous cell carcinoma (HNSCC). METHODS: Among 772 patients with HNSCC diagnosed at our hospital over 9 years, 30 patients (3.9%) had clinical evidence of BM (24 men and 6 women; mean age: 63 years). We assessed the time interval from the primary diagnosis to BM development, symptoms attributable to BM, presence of distant metastases to other organs, number of BM, sites of BM, morphologic changes on computed tomography (CT) images, treatment for BM, and overall survival (OS). RESULTS: BM at the initial stage were found in 9 patients with HNSCC (30%), and in 21 patients (70%) with HNSCC during the course of the disease. In the later patients, the median time interval from the primary diagnosis was 11.5 months. Nineteen patients (63%) did not have BM-related symptoms, 6 (20%) had pain, 3 (10%) had neurologic symptoms resulting from vertebral or skull metastases, and 2 (7%) had hypercalcemia. Seventeen patients (57%) showed bone-exclusive metastases, and 13 (43%) had distant metastases in other organs. Eleven patients (37%) had monostotic metastases (solitary BM), and 19 patients (63%) had polyostotic metastases (multiple BM). When combined, 9 patients (30%) showed bone-exclusive and monostotic metastases. The most commonly affected site was the thoracolumbar spine, accounting for 34% of total BM, followed by the pelvis (24%), shoulder and thorax (21%), and the extremities (17%). Notably, metastases to bones above the clavicle (craniofacial bones and cervical spine) accounted for only 3% of all bone lesions. CT images showed variable morphologic patterns with osteolytic type in 17 patients (57%), intertrabecular in 7 (23%), osteoblastic in 4 (13%), and mixed in 2 (7%). Systematic chemotherapy for BM was performed in 19 patients and radiotherapy in 18. The median survival time for patients with bone-exclusive and monostotic metastases was significantly longer than that for patients with multi-organ metastases or polyostotic metastases at 18.2 months vs. 5.7 months (p=0.02). Neither chemotherapy nor radiotherapy extended OS. CONCLUSION: Thirty percent of BM cases from HNSCC showed bone-exclusive and monostotic metastases. These patients tended to show a more favorable prognosis than patients with multi-organ metastases or polyostotic metastases.
• A strategy to account for noise in the X-variable to reduce underestimation in Logan graphical analysis for quantifying receptor density in positron emission tomography.

  Paulus K Shigwedha; Takahiro Yamada; Kohei Hanaoka; Kazunari Ishii; Yuichi Kimura; Yutaka Fukuoka

  BMC medical imaging 20 (1) 15 - 15 2020/02 [Refereed]
   

  BACKGROUND: The Logan graphical analysis (LGA) algorithm is widely used to quantify receptor density for parametric imaging in positron emission tomography (PET). Estimating receptor density, in terms of the non-displaceable binding potential (BPND), from the LGA using the ordinary least-squares (OLS) method has been found to be negatively biased owing to noise in PET data. This is because OLS does not consider errors in the X-variable (predictor variable). Existing bias reduction methods can either only reduce the bias slightly or reduce the bias accompanied by increased variation in the estimates. In this study, we addressed the bias reduction problem by applying a different regression method. METHODS: We employed least-squares cubic (LSC) linear regression, which accounts for errors in both variables as well as the correlation of these errors. Noise-free PET data were simulated, for 11C-carfentanil kinetics, with known BPND values. Statistical noise was added to these data and the BPNDs were re-estimated from the noisy data by three methods, conventional LGA, multilinear reference tissue model 2 (MRTM2), and LSC-based LGA; the results were compared. The three methods were also compared in terms of beta amyloid (A β) quantification of 11C-Pittsburgh compound B brain PET data for two patients with Alzheimer's disease and differing A β depositions. RESULTS: Amongst the three methods, for both synthetic and actual data, LSC was the least biased, followed by MRTM2, and then the conventional LGA, which was the most biased. Variations in the LSC estimates were smaller than those in the MRTM2 estimates. LSC also required a shorter computational time than MRTM2. CONCLUSIONS: The results suggest that LSC provides a better trade-off between the bias and variability than the other two methods. In particular, LSC performed better than MRTM2 in all aspects; bias, variability, and computational time. This makes LSC a promising method for BPND parametric imaging in PET studies.
• Automatic delineation algorithm of reference region for amyloid imaging based on kinetics

  Takahiro Yamada; Shogo Watanabe; Takashi Nagaoka; Mitsutaka Nemoto; Kohei Hanaoka; Hayato Kaida; Kazunari Ishii; Yuichi Kimura

  ANNALS OF NUCLEAR MEDICINE SPRINGER 34 (2) 102 - 107 0914-7187 2020/02 [Refereed]
   

  Objective This study aims to develop an algorithm named AutoRef to delineate a reference region for quantitative PET amyloid imaging. Methods AutoRef sets the reference region automatically using a distinguishing feature in the kinetics of reference region. This is reflected in the shapes of the tissue time activity curve. A statistical shape recognition algorithm of the gaussian mixture model is applied with considering spatial and temporal information on a reference region. We evaluate the BPND with manually set reference region and AutoRef using 86 cases (43 positive cases, 10 equivocal cases, and 33 negative cases) of dynamically scanned C-11-Pittsburgh Compound-B. Results From the Bland-Altman plot, the difference between two BPND is 0.099 +/- 0.21 as standard deviation, and no significant systematic error is observed between the BPND with AutoRef and with manual definition of a reference region. Although a proportional error is detected, it is smaller than the 95% limits of agreement. Therefore, the proportional error is negligibly small. Conclusions AutoRef presents the same performance as the manual definition of the reference region. Further, since AutoRef is more algorithmic than the ordinary manual definition of the reference region, there are few operator-oriented uncertainties in AutoRef. We thus conclude that AutoRef can be applied as an automatic delineating algorithm for the reference region in amyloid imaging.
• Evaluation of PiB visual interpretation with CSF Aβ and longitudinal SUVR in J-ADNI study.

  Yusuke Okada; Takashi Kato; Kaori Iwata; Yasuyuki Kimura; Akinori Nakamura; Hideyuki Hattori; Hiroshi Toyama; Kazunari Ishii; Kenji Ishii; Michio Senda; Kengo Ito; Takeshi Iwatsubo

  Annals of nuclear medicine 34 (2) 108 - 118 0914-7187 2020/02 [Refereed]
   

  OBJECTIVE: The objectives of the present study were to investigate (1) whether trinary visual interpretation of amyloid positron emission tomography (PET) imaging (negative/equivocal/positive) reflects quantitative amyloid measurements and the time course of 11C-Pittsburgh compound B (PiB) amyloid accumulation, and (2) whether visually equivocal scans represent an early stage of the Alzheimer's disease (AD) continuum in terms of an intermediate state of quantitative amyloid measurements and the changes in amyloid accumulation over time. METHODS: From the National Bioscience Database Center Human Database of the Japanese Alzheimer's Disease Neuroimaging Initiative, we selected 133 individuals for this study including 33 with Alzheimer's disease dementia (ADD), 52 with late mild cognitive impairment (LMCI), and 48 cognitively normal (CN) subjects who underwent clinical assessment, PiB PET, and structural magnetic resonance imaging (MRI) with 2 or 3-years of follow-up. Sixty-eight of the 133 individuals underwent cerebrospinal fluid amyloid-β1-42 (CSF-Ab42) analysis at baseline. The standard uptake value ratio (SUVR) of PiB PET was calculated with a method using MRI at each visit. The cross-sectional values, longitudinal changes in SUVR, and baseline CSF-Ab42 were compared among groups, which were categorized based on trinary visual reads of amyloid PET (negative/equivocal/positive). RESULTS: From the trinary visual interpretation of the PiB PET images, 55 subjects were negative, 8 were equivocal, and 70 were positive. Negative interpretation was most frequent in the CN group (70.8/10.4/18.8%: negative/equivocal/positive), and positive was most frequent in the LMCI group (34.6/1.9/63.5%) and in the ADD group (9.1/6.1/84.8%). The baseline SUVRs were 1.08 ± 0.06 in the negative group, 1.23 ± 0.15 in the equivocal group, and 1.86 ± 0.31 in the positive group (F = 174.9, p < 0.001). The baseline CSF-Ab42 level was 463 ± 112 pg/mL in the negative group, 383 ± 125 pg/mL in the equivocal group, and 264 ± 69 pg/mL in the positive group (F = 37, p < 0.001). Over the 3-year follow-up, annual changes in SUVR were - 0.00 ± 0.02 in the negative group, 0.02 ± 0.02 in the equivocal group, and 0.04 ± 0.07 in the positive group (F = 8.4, p < 0.001). CONCLUSIONS: Trinary visual interpretation (negative/equivocal/positive) of amyloid PET imaging reflects quantitative amyloid measurements evaluated with PET and the CSF amyloid test as well as the amyloid accumulation over time evaluated with PET over 3 years. Subjects in the early stage of the AD continuum could be identified with an equivocal scan, because they showed intermediate quantitative amyloid PET, CSF measurements, and the amyloid accumulation over time.
• The Landscape Montage Technique for diagnosing frontotemporal dementia starting as primary progressive aphasia: a case report.

  Masahiko Takaya; Kazunari Ishii; Isao Kubota; Osamu Shirakawa

  Journal of medical case reports 14 (1) 5 - 5 2020/01 [Refereed]
   

  BACKGROUND: The Landscape Montage Technique was originally developed by Hisao Nakai, a Japanese psychiatrist, to pursue the possibility and application of a psychotherapeutic approach using drawing for patients with schizophrenia. Drawing was initially adopted to evaluate patients with an impaired ability for verbal expression, particularly for the diagnosis and treatment of patients with schizophrenia. Since its development, the Landscape Montage Technique has been utilized in various clinical settings throughout Japan. This study aimed to evaluate the psychiatric conditions of a patient diagnosed as having primary progressive aphasia using the Landscape Montage Technique at a 3-year follow-up. CASE PRESENTATION: We present the case of a 64-year-old, right-handed Japanese woman initially diagnosed as having logopenic variant primary progressive aphasia or logopenic aphasia. At a 3-year follow-up, logopenic aphasia progressed to behavioral variant frontotemporal dementia or frontotemporal dementia. According to her husband, she began to have speech difficulties approximately 5 years before her first visit. The results of neurocognitive tests suggested mild cognitive impairment or early stages of dementia. Her clinical dementia rating score was 0.5, suggesting a diagnosis of mild cognitive impairment. She had a Raven's Colored Progressive Matrices score of 31 out of 36, which indicated a nonverbal cognitive ability that was greater than the 90th percentile for her age. The Japanese Standard Language Test of Aphasia, which was performed at two points during the follow-up, indicated the possibility for a diagnosis of primary progressive aphasia given the progression of her aphasia. Based on her clinical symptoms and Japanese Standard Language Test of Aphasia results, a diagnosis of logopenic variant primary progressive aphasia was established. Magnetic resonance imaging revealed severe predominant left frontal and anterior temporal atrophy, as well as bilateral parietal atrophy. Amyloid beta deposition was negative. At the 3-year follow-up, logopenic variant primary progressive aphasia had progressed to behavioral variant frontotemporal dementia. However, the Landscape Montage Technique allowed for the diagnosis of behavioral variant frontotemporal dementia only 2 years after baseline. CONCLUSIONS: The present study showed that the Landscape Montage Technique can be useful for diagnosing behavioral variant frontotemporal dementia that starts as logopenic variant primary progressive aphasia at earlier stages.
• Effectiveness of high-luminance display monitors in digital mammography

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Koji Yamada; Yoshiaki Ozaki; Kazunari Ishii; Yongbum Lee

  15TH INTERNATIONAL WORKSHOP ON BREAST IMAGING (IWBI2020) SPIE-INT SOC OPTICAL ENGINEERING 11513 0277-786X 2020 

  Receiver operating characteristic (ROC) examination was performed to investigate the effectiveness of high-luminance monitors in digital X-ray mammography. For this purpose, an original breast phantom consisting of adipose and fibroglandular equivalent tissues with an identical X-ray absorption characteristic over the entire mammographic photon energy range was developed. Furthermore, the phantom's fibroglandular density and distribution could be changed arbitrarily. Three types of lesions, microcalcification, mass, and spiculated, were inserted into the breast phantom, and the ROC examination was performed by five radiological technologists certified in screening mammography, to obtain the area under the curve. A liquid crystal display (LCD) monitor with 5 megapixels in a 21-inch display size calibrated to a grayscale standard display function curve was used for the observation. The monitor was set to 600, 900, and 1200 cd/m(2) in maximum luminance. The experimental details were fibroglandular density of 25%, respective 50 positive and negative images, and free observation time and distance. As a result, the dependence on monitor luminance differed according to the lesion type. The detectability of microcalcification increased with the increase in the luminance of the monitor. Spiculated lesions were similar for all luminance changes. The detectability of mass lesions was significantly higher at 900 cd/m(2) than at 600 cd/m(2). There was no significant difference between those at 900 cd/m(2) and 1200 cd/m(2). In conclusion, the maximum luminance of the diagnostic LCD monitor for mammography should be at least 900 cd/m(2) to guarantee stable detectability.
• Deep learning-based segmentation of mammary gland region in digital mammograms of scattered mammary glands and fatty breasts

  Mika Yamamuro; Yoshiyuki Asai; Naomi Hashimoto; Nao Yasuda; Kenta Sakaguchi; Tatsuo Konishi; Koji Yamada; Yoshiaki Ozaki; Kazunari Ishii; Yougbum Lee

  15TH INTERNATIONAL WORKSHOP ON BREAST IMAGING (IWBI2020) SPIE-INT SOC OPTICAL ENGINEERING 11513 0277-786X 2020 

  This study is aimed to automatically segment mammary gland region into scattered mammary glands and fatty breasts using deep learning method. Total 433 mediolateral oblique-view mammograms of Japanese women were collected and confirmed for scattered mammary glands or fatty breasts; using BI-RADS's classification. First, manually contoured mammary gland regions were determined for all mammograms as ground truths by three certified radiological technologists. Second, the U-net model was employed to segment the mammary gland region automatically. This model is a type of convolutional neural network (CNN) mainly aimed at medical image segmentation. The segmentation accuracies were assessed based on five criteria, Dice coefficients, breast densities, mean gray values, centroids, and sizes of mammary gland region. The Dice coefficient was 0.915. The mean size of mammary gland regions obtained by the Unet was 8.7% larger than that of the ground truths. The mean centroid coordinates of mammary gland regions by the U-net were shifted 1.6 and 5.4 mm on average in mediolateral and craniocaudal directions, respectively from ground truths. The mean gray value of mammary gland regions obtained by the U-net was only 0.4% higher compared with ground truths. The resultant difference was 0.4% on average in breast densities between ground truths and the segmented mammary gland regions. We found significant similarity in the ground truths and the data generated by deep learning on all the parameters, thereby attesting the efficacy of this method for segmenting the mammary gland regions of not only the dense breasts but also the scattered mammary gland- and fatty- breasts.
• Quantitative Evaluation of 18F-Flutemetamol PET in Patients With Cognitive Impairment and Suspected Alzheimer's Disease: A Multicenter Study.

  Hiroshi Matsuda; Kengo Ito; Kazunari Ishii; Eku Shimosegawa; Hidehiko Okazawa; Masahiro Mishina; Sunao Mizumura; Kenji Ishii; Kyoji Okita; Yoko Shigemoto; Takashi Kato; Akinori Takenaka; Hayato Kaida; Kohei Hanaoka; Keiko Matsunaga; Jun Hatazawa; Masamichi Ikawa; Tetsuya Tsujikawa; Miyako Morooka; Kenji Ishibashi; Masashi Kameyama; Tensho Yamao; Kenta Miwa; Masayo Ogawa; Noriko Sato

  Frontiers in neurology 11 578753 - 578753 2020 

  Background: In clinical practice, equivocal findings are inevitable in visual interpretation of whether amyloid positron emission tomography (PET) is positive or negative. It is therefore necessary to establish a more objective quantitative evaluation method for determining the indication for disease-modifying drugs currently under development. Aims: We aimed to determine cutoffs for positivity in quantitative analysis of 18F-flutemetamol PET in patients with cognitive impairment and suspected Alzheimer's disease (AD). We also evaluated the clinical efficacy of amyloid PET in the diagnosis of AD. This study was registered in the Japan Registry of Clinical Trials (jRCTs, 031180321). Methods: Ninety-three patients suspected of having AD underwent 18F-flutemetamol PET in seven institutions. A PET image for each patient was visually assessed and dichotomously rated as either amyloid-positive or amyloid-negative by two board-certified nuclear medicine physicians. If the two readers obtained different interpretations, the visual rating was rerun until they reached consensus. The PET images were quantitatively analyzed using the standardized uptake value ratio (SUVR) and standardized Centiloid (CL) scale with the whole cerebellum as a reference area. Results: Visual interpretation obtained 61 positive and 32 negative PET scans. Receiver operating characteristic analysis determined the best agreement of quantitative assessments and visual interpretation of PET scans to have an area under curve of 0.982 at an SUVR of 1.13 and a CL of 16. Using these cutoff values, there was high agreement between the two approaches (kappa = 0.88). Five discordant cases had SUVR and CL values ranging from 1.00 to 1.22 and from 1 to 26, respectively. In these discordant cases, either diffuse or mildly focal elevation of cortical activity confused visual interpretation. The amyloid PET outcome significantly altered the diagnosis of AD (χ2 = 51.3, p < 0.0001). PET imaging elevated the proportions of the very high likelihood category from 20.4 to 46.2% and the very low likelihood category from 0 to 22.6%. Conclusion: Quantitative analysis of amyloid PET using 18F-flutemetamol can objectively evaluate amyloid positivity using the determined cutoffs for SUVR and CL. Moreover, amyloid PET may have added value over the standard diagnostic workup in dementia patients with cognitive impairment and suspected AD.
• Association between the Onset of Idiopathic Normal Pressure Hydrocephalus Symptoms and Reduced Default Mode Network Connectivity.

  Koichi Miyazaki; Kohei Hanaoka; Hayato Kaida; Yasutaka Chiba; Kazunari Ishii

  Dementia and geriatric cognitive disorders 49 (3) 255 - 263 2020 [Refereed]
   

  OBJECTIVE: The aim was to examine the association between connectivity changes in the default mode network (DMN) and the progression of idiopathic normal pressure hydrocephalus (iNPH). METHODS: We retrospectively recruited cases of preclinical and clinical iNPH from 2,196 patients who had received whole-body 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) scanning. We included 31 cases with asymptomatic ventriculomegaly with features of iNPH on MRI (AVIM; reported as preclinical iNPH) and 12 with iNPH. We performed a voxel-based analysis of the brain FDG-PET images of the AVIM and iNPH groups as well as for each background-matched normal control (NC) group, using Statistical Parametric Mapping 12. Volume of interest (VOI)-based analysis was also performed. We set the VOI as the region from the precuneus to the posterior cingulate cortices (PCC), and compared the mean regional standardized uptake value ratio (SUVR) between the AVIM and iNPH group FDG-PET/CT images and each corresponding NC group. RESULTS: The voxel-based analysis showed a greater decreased FDG uptake in the PCC in the iNPH group than in the AVIM group. The VOI-based analysis revealed no significant difference in the mean SUVR of the AVIM group and the corresponding NC group, but that of the iNPH group was significantly lower than that of its corresponding NC group. CONCLUSIONS: DMN connectivity was reduced in the clinical iNPH group but not in the preclinical group. These data suggest that alterations in the functional connectivity of the DMN are related to the onset of iNPH symptoms.
• Improved Risk Stratification for Progression from Mild Cognitive Impairment to Alzheimer's Disease with a Multi-Analytical Evaluation of Amyloid-β Positron Emission Tomography.

  Leonie Beyer; Matthias Brendel; Franziska Scheiwein; Julia Sauerbeck; Chisa Hosakawa; Ian Alberts; Kuangyu Shi; Peter Bartenstein; Kazunari Ishii; John Seibyl; Paul Cumming; Axel Rominger

  Journal of Alzheimer's disease : JAD 74 (1) 101 - 112 2020 [Refereed]
   

  BACKGROUND: Amyloid-β (Aβ) accumulation in brain of patients with suspected Alzheimer's disease (AD) can be assessed by positron emission tomography (PET) in vivo. While visual classification prevails in the clinical routine, semiquantitative PET analyses may enable more reliable evaluation of cases with a visually uncertain, borderline Aβ accumulation. OBJECTIVE: We evaluated different analysis approaches (visual/semiquantitative) to find the most accurate and sensitive interpretation of Aβ-PET for predicting risk of progression from mild cognitive impairment (MCI) to AD. METHODS: Based on standard uptake value (SUV) ratios of a cortical-composite volume of interest of 18F-AV45-PET from MCI subjects (n = 396, ADNI database), we compared three different reference region (cerebellar grey matter, CBL; brainstem, BST; white matter, WM) normalizations and the visual read by receiver operator characteristics for calculating a hazard ratio (HR) for progression to Alzheimer's disease dementia (ADD). RESULTS: During a mean follow-up time of 45.6±13.0 months, 28% of the MCI cases (110/396) converted to ADD. Among the tested methods, the WM reference showed best discriminatory power and progression-risk stratification (HRWM of 4.4 [2.6-7.6]), but the combined results of the visual and semiquantitative analysis with all three reference regions showed an even higher discriminatory power. CONCLUSION: A multi-analytical composite of visual and semiquantitative reference tissue analyses of 18F-AV45-PET gave improved risk stratification for progression from MCI to ADD relative to performance of single read-outs. This optimized approach is of special interest for prospective treatment trials, which demand a high accuracy.
• Navigator-triggered and breath-hold 3D MRCP using compressed sensing: Image quality and method selection factor assessment

  Morimoto D; Hyodo T; Kamata K; Kadoba T; Itoh M; Fukushima H; Chiba Y; Takenaka M; Mochizuki T; Ueda Y; Miyagoshi K; Kudo M; Ishii K

  Abdominal Radiology [Epub ahead of print] 2366-0058 2020/01 [Refereed]
  
• Diagnostic imaging of dementia with Lewy bodies, frontotemporal lobar degeneration, and normal pressure hydrocephalus

  Kazunari Ishii

  Japanese Journal of Radiology Springer Science and Business Media {LLC} 38 (1) 64 - 76 1867-1071 2020/01 [Refereed]
   

  Neuroimaging can provide important biomarkers and is very useful for supporting dementia diagnosis. This review summarizes the neuroimaging findings of dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD), and normal pressure hydrocephalus (NPH). In DLB, medial temporal atrophy is milder than that of Alzheimer's disease. 2-fluoro-2-deoxy-D-glucose-positron emission tomography and brain perfusion single-photon emission computed tomography demonstrate hypometabolism and hypoperfusion in the occipital lobe, in addition to decreased metabolism and perfusion in the parietotemporal, posterior cingulate, precuneus, and frontal association cortices. The cingulate island sign, which shows relatively spared middle-to-posterior cingulate cortex metabolism compared with precuneus hypometabolism, is proposed to detect DLB in 2-fluoro-2-deoxy-D-glucose-positron emission tomography imaging. Reduced uptake in dopamine transporter imaging and reduced myocardial uptake in iodine-123 metaiodobenzylguanidine cardiac scintigraphy are indicative biomarkers for DLB diagnosis. Characteristic findings of FTLD include dominant frontotemporal atrophy, hypometabolism, and hypoperfusion. Most idiopathic NPH cases demonstrate disproportionally enlarged subarachnoid space hydrocephalus findings, including dilated ventricular systems, enlarged Sylvian fissures, tight sulci in the midline, and a high convexity.
• Prognostic value of dual-point fluorine-18 fluorodeoxyglucose PET imaging, partial volume correction and glucose transporter-1 expression in resected nonsmall cell lung cancer patients.

  Hayato Kaida; Koichi Azuma; Akihiko Kawahara; Shinzo Takamori; Jun Akiba; Kiminori Fujimoto; Kazunari Ishii; Masatoshi Ishibashi

  Nuclear medicine communications 41 (1) 48 - 57 0143-3636 2020/01 [Refereed]
   

  OBJECTIVE: To investigate the relationship between the prognosis and glucose transporter-1 (Glut-1) expression or fluorine-18 fluorodeoxyglucose uptake using partial volume correction and dual-point imaging in surgically resected nonsmall cell lung cancer (NSCLC) patients. METHODS: Our patient population consisted of 108 NSCLC cases. The early maximum standardized uptake value (ESUVmax), delayed SUVmax (DSUVmax), partial volume correction SUVmax (cSUVmax) and retention index of primary lesions were calculated. Cox proportional hazard model was applied to evaluate the effects of PET parameters and Glut-1 expression. Overall survival (OS) and disease-free survival (DFS) were evaluated by Kaplan-Meier methods, and the difference in survival between subgroups was analyzed by log-rank test. RESULTS: On the Cox regression analysis, ESUVmax, DSUVmax, cSUVmax and Glut-1 were significantly related to DFS [ESUVmax, hazard ratio = 2.301, 95% confidential interval (CI) = 1.146-4.618, P = 0.019; DSUVmax, hazard ratio = 2.483, 95% CI = 1.257-4.905, P = 0.009; cSUVmax, hazard ratio = 2.205, 95% CI = 1.038-4.686, P = 0.04; Glut-1, hazard ratio = 2.095, 95% CI = 1.086-4.041, P = 0.001] and OS (ESUVmax, hazard ratio = 3.197, 95% CI = 1.339-7.633, P = 0.009; DSUVmax, hazard ratio = 3.599, 95% CI = 1.521-8.516, P = 0.004; cSUVmax, hazard ratio = 8.655, 95% CI = 2.048-36.658, P = 0.003; Glut-1, hazard ratio = 2.427, 95% CI = 5.140, P = 0.021). Retention index had no significant association with DFS or OS. On the Kaplan-Meier survival curves, the patients with high ESUVmax, DSUVmax, cSUVmax and Glut-1 showed significantly worse prognosis than those with low values (ESUVmax: DFS, P = 0.001, OS, P = 0.003; DSUVmax: DFS, P = 0.002, OS, P = 0.004; cSUVmax: DFS, P < 0.001, OS, P = 0.013; Glut-1: DFS, P = 0.012, OS, P = 0.002). CONCLUSIONS: cSUVmax, ESUVmax, DSUVmax and Glut-1 may be more useful biomarkers than retention index for predicting outcomes in NSCLC patients.
• Changes in cerebral glucose metabolism caused by morphologic features of prodromal idiopathic normal pressure hydrocephalus.

  Koichi Miyazaki; Kohei Hanaoka; Hayato Kaida; Yasutaka Chiba; Kazunari Ishii

  EJNMMI research 9 (1) 111 - 111 2019/12 [Refereed]
   

  BACKGROUND: Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance in the preclinical stage of iNPH remains unknown. Herein, we evaluated the changes in regional cerebral glucose metabolism with respect to the characteristic morphologic features of iNPH. METHODS: We performed a cross-sectional study in > 2000 elderly patients who received a whole body 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scanning and recruited subjects with clinical and preclinical iNPH. We included 12 subjects with iNPH, 32 subjects with asymptomatic ventriculomegaly with features of iNPH on magnetic resonance imaging (AVIM), and 33 subjects with preclinical morphologic features of DESH (PMD). We previously reported that iNPH develops in the order of PMD (asymptomatic subjects with incomplete DESH), AVIM (asymptomatic subjects with DESH), and iNPH (symptomatic subjects with DESH). We measured the median regional standardized uptake value ratio (SUVR) on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography images between the three groups and compared them with background-matched normal controls in the frontal lobes, temporal lobes, medial parietal lobes, striata, and thalami. RESULTS: In the frontal and temporal lobes, the SUVR distributions of the PMD, AVIM, and PMD groups were significantly lower than for each NC (p < 0.05 for all). In the medial parietal lobes, the SUVR distributions were significantly higher in PMD and AVIM groups (p < 0.05 for all). In the thalami and striata, the SUVR distributions were significantly lower in the iNPH group (p < 0.05 for all). CONCLUSIONS: Changes in brain glucose metabolism in the cortices are observed in preclinical iNPH, while metabolic decline in the basal ganglia is only detected in clinical iNPH.
• The Tight Medial and High Convexity Subarachnoid Spaces Is the First Finding of Idiopathic Normal Pressure Hydrocephalus at the Preclinical Stage.

  Koichi Miyazaki; Kazunari Ishii; Kohei Hanaoka; Hayato Kaida; Koichi Nakajima

  Neurologia medico-chirurgica 59 (11) 436 - 443 0470-8105 2019/11 [Refereed]
   

  Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) findings are often reported as characteristic radiological features of idiopathic normal pressure hydrocephalus (iNPH). However, the process of development of DESH remains unclear. The aim of the present study was to determine the dynamic deforming process and pathophysiology of iNPH. All patients >50 years of age who underwent whole body FDG-PET/CT scanning at Kindai University Hospital between May 2017 and April 2018 were included in this retrospective study, and their brain image findings and clinical information were assessed. We defined DESH-like findings, which had one or two equivocal features of the three components of DESH findings, as preclinical morphologic features of DESH (PMD). PMD were classified into six subtypes based on their component of DESH findings: PMD-T, only tight medial and high convexity subarachnoid spaces (TMC); PMD-S, only enlarged Sylvian fissures; PMD-V, only ventriculomegaly; PMD-TV, TMC and ventriculomegaly; PMD-TS, TMC and enlarged Sylvian fissures; PMD-SV, enlarged Sylvian fissures and ventriculomegaly. A total of 2196 cases (70.5 ± 9.3 years) were enrolled, with 54 cases (77.1 ± 5.9 years) with DESH findings, and 42 cases (72.9 ± 7.9 years) with PMD (five PMD-T, two PMD-V, 12 PMD-TV, 18 PMD-TS, and five PMD-SV). In each component of DESH, 35 of 42 (83.3%) cases with PMD had TMC. We suggest that the TMC is the first change on DESH findings in most iNPH cases, and may be an important part of the pathophysiology of iNPH.
• Diagnostic Utility of Cardiac Magnetic Resonance/F-18-fluorodeoxyglcose Positron Emission Tomography Fusion Imaging in Cardiac Sarcoidosis

  Masakazu Yasuda; Yoshinori Kagioka; Mana Okune; Kakehi Kazuyoshi; Takayuki Kawamura; Hayato Kaida; Kazunari Ishii; Yoshitaka Iwanaga

  CIRCULATION LIPPINCOTT WILLIAMS & WILKINS 140 0009-7322 2019/11 

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• Changes in brain morphology in patients in the preclinical stage of idiopathic normal pressure hydrocephalus.

  Takashi Suehiro; Hiroaki Kazui; Hideki Kanemoto; Kenji Yoshiyama; Shunsuke Sato; Yukiko Suzuki; Shingo Azuma; Takuya Matsumoto; Haruhiko Kishima; Kazunari Ishii; Manabu Ikeda

  Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 19 (6) 557 - 565 1346-3500 2019/11 [Refereed]
   

  BACKGROUND: Specific ventriculomegaly features, including tight high-convexity and medial subarachnoid spaces, are found on magnetic resonance images in patients with idiopathic normal pressure hydrocephalus (iNPH). However, some healthy elderly individuals with no typical triad symptoms of iNPH also exhibit specific magnetic resonance image features of iNPH. Therefore, this study quantitatively clarified the brain morphology of suspected iNPH patients with no objective triad symptoms (iNPH-NOS). METHODS: We recruited patients with suspected iNPH and divided them into two groups based on their iNPH grading scale scores: the iNPH-NOS group and the iNPH with apparent objective triad symptoms (iNPH-AOS) group. Data for normal controls (NC) were taken from the database used in our previous study. We compared the relative volumes of ventricle systems (VS), Sylvian fissures (SF), and sulci at high convexity and the midline (SHM), adjusted by the intracranial volume, of the iNPH-NOS, iNPH-AOS, and NC groups. Additionally, we compared the relative volumes of VS, SF, and SHM in iNPH-NOS patients between their first visit and follow-up 1 year later. RESULTS: Fifteen iNPH-NOS patients and 45 iNPH-AOS patients were recruited, and 24 NCs were found in the database. The relative volumes of VS and SF were significantly smaller than in NCs than in the iNPH-NOS and iNPH-AOS groups, and the relative volume of SHM was significantly larger in NCs. The relative volume of SHM was significantly larger in the iNPH-NOS group than in the iNPH-AOS group, but there were no significant differences in the relative volumes of VS and SF between these groups. In the iNPH-NOS group, the relative volumes of VS and SF were significantly smaller at the first visit than 1 year later, whereas the relative volume of SHM was significantly larger. In 6 of 15 iNPH-NOS patients, objective symptoms appeared during the observation period. CONCLUSIONS: Our results indicate that iNPH-NOS patients were in the transitional stage between normal and iNPH-AOS, both morphologically and clinically.
• アミロイドPET病理陽性率に対するAPOE4の影響 J-ADNI研究(The effect of APOE4 to the amytoid PET positive rate: A J-ADNI Study)

  岡田 佑介; 加藤 隆司; 木村 泰之; 中村 昭範; 服部 英幸; 外山 宏; 石井 一成; 石井 賢二; 千田 道雄; 伊藤 健吾; 岩坪 威

  核医学 (一社)日本核医学会 56 (Suppl.) S174 - S174 0022-7854 2019/10
• MRI、FDG画像で解剖学的標準化する方法とCapAIBLとのアミロイドPET SUVR値の比較検討

  竹中 章倫; 岡田 佑介; 岩田 香織; 加藤 隆司; 木村 泰之; 中村 昭範; 石井 一成; 石井 賢二; 千田 道雄; 伊藤 健吾; 岩坪 威

  核医学 (一社)日本核医学会 56 (Suppl.) S174 - S174 0022-7854 2019/10
• 当施設で開発したPiB PET皮質平均SUVR値の算出法とCapAIBLとの互換性の検討

  竹中 章倫; 岡田 佑介; 岩田 香織; 加藤 隆司; 木村 泰之; 中村 昭範; 外山 宏; 石井 一成; 石井 賢二; 千田 道雄; 伊藤 健吾; 岩坪 威

  Dementia Japan (一社)日本認知症学会 33 (4) 553 - 553 1342-646X 2019/10
• 【認知症の画像診断〜ルーチン検査から最新の画像検査まで〜】認知症の画像検査 Brain Imaging in Dementia

  花岡 宏平; 石井 一成

  Rad Fan (株)メディカルアイ 17 (13) 13 - 17 1348-3498 2019/10 

  認知症は認知障害の一種であり、後天的器質的障害によって生じ、いったん正常に発達した知能が不可逆的に低下した状態である。形態画像であるCTやMRI、機能画像であるSPECT検査やPET検査の技術は認知症を知る上で大きな役割を果たしている。これらの脳画像検査を適切に活用することは、認知症における解剖学的および機能的な評価を可能にする。(著者抄録)
• AI異常検知に基づくPET/CT上の頸胸部病変の自動認識

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 山田 誉大; 牛房 和之; 花岡 宏平; 北島 一宏; 槌谷 達也; 石井 一成

  核医学 (一社)日本核医学会 56 (Suppl.) S154 - S154 0022-7854 2019/10
• FDG PET/CTによる食道癌術前化学療法の治療効果判定に関する検討

  甲斐田 勇人; 白石 治; 岩間 密; 加藤 寛章; 木村 豊; 花岡 宏平; 山田 穣; 北島 一宏; 安田 卓司; 石井 一成

  核医学 (一社)日本核医学会 56 (Suppl.) S155 - S155 0022-7854 2019/10
• 認知症自動診断AIアルゴリズム学習のための深層学習によるアミロイド画像の加増手法の検討

  渡邉 綾; 山田 誉大; 永岡 隆; 根本 充貴; 花岡 宏平; 甲斐田 勇人; 石井 一成; 木村 裕一

  核医学 (一社)日本核医学会 56 (Suppl.) S178 - S178 0022-7854 2019/10
• Voxel-based statistical analysis and quantification of amyloid PET in the Japanese Alzheimer's disease neuroimaging initiative (J-ADNI) multi-center study.

  Go Akamatsu; Yasuhiko Ikari; Akihito Ohnishi; Keiichi Matsumoto; Hiroyuki Nishida; Yasuji Yamamoto; Michio Senda

  EJNMMI research 9 (1) 91 - 91 2019/09 

  BACKGROUND: Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well studied. The purpose of this study was to examine the feasibility of analyzing amyloid PET scans by voxel-based statistical analysis. The results were then compared to those with the ROI-based mcSUVR. In total, 166 subjects who underwent 11C-PiB PET in the J-ADNI multi-center study were analyzed. Additionally, 18 Aβ-negative images were collected from other studies to form a normal database. The PET images were spatially normalized to the standard space using an adaptive template method without MRI. The mcSUVR was measured using a pre-defined ROI. Voxel-wise Z-scores within the ROI were calculated using the normal database, after which Z-score maps were generated. A receiver operating characteristic (ROC) analysis was performed to evaluate whether Z-sum (sum of the Z-score) and mcSUVR could be used to classify the scans into positive and negative using the central visual read as the reference standard. PET scans that were equivocal were regarded as positive. RESULTS: Sensitivity and specificity were respectively 90.8% and 100% by Z-sum and 91.8% and 98.5% by mcSUVR. Most of the equivocal scans were subsequently classified by both Z-sum and mcSUVR as false negatives. Z-score maps correctly delineated abnormal Aβ accumulation over the same regions as the visual read. CONCLUSIONS: We examined the usefulness of voxel-based statistical analysis for amyloid PET. This method provides objective Z-score maps and Z-sum values, which were observed to be helpful as an adjunct to visual interpretation especially for cases with mild or limited Aβ accumulation. This approach could improve the Aβ detection sensitivity, reduce inter-reader variability, and allow for detailed monitoring of Aβ deposition. TRIAL REGISTRATION: The number of the J-ADNI study is UMIN000001374.
• 肝細胞癌術後胆汁瘻に対し経皮的アプローチと内視鏡的アプローチを組み合わせてステント留置を施行した1例

  鈴木 絢子; 沼本 勲男; 鶴崎 正勝; 小田 晃義; 門場 智也; 柳生 行伸; 石井 一成; 岡本 彩那; 三長 孝輔; 岩崎 寿光

  日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 34 (1) 79 - 79 1340-4520 2019/09
• 【苦手克服!よくわかる膜・間隙の画像診断】女性骨盤腔にて膜・靱帯・間隙を意識した画像診断

  松久保 祐子; 松木 充; 若菜 みゆき; 鈴木 絢子; 浜川 岳文; 沼本 勲男; 門場 智也; 兵頭 朋子; 鶴崎 正勝; 石井 一成

  画像診断 (株)学研メディカル秀潤社 39 (12) 1308 - 1322 0285-0524 2019/09 

  ＜文献概要＞女性骨盤領域には,重要な臓器として子宮,卵巣,卵管があり,それを覆う間膜や支持する靱帯,また支配する血管,神経が存在する.画像上直接同定できる靱帯や血管あるいは尿管などをランドマークとして走行を推定する間膜,靱帯がある.これら間膜,靱帯,血管の解剖学的な知識は,我々放射線科医にとって非常に重要で,病変の占拠部位,広がり,あるいは病態を把握する上で,必要不可欠なものである.
• Pittsburgh Compound-B Uptake in Meningioma With Histopathologic Correlation.

  Shuhei Doi; Nobuo Kashiwagi; Takao Satou; Hayato Kaida; Kazunari Ishii

  Clinical nuclear medicine 44 (7) 587 - 588 2019/07 [Refereed]
   

  Previous studies have reported increased Pittsburgh compound-B (PiB) uptake in meningiomas; however, histological correlation to elucidate the underlying mechanism has not yet been done. We report a case of an 82-year-old woman with an incidental intracranial tumor that showed focal increased PiB uptake. Because of tumor growth, surgical resection was performed, yielding a histological diagnosis of meningioma. Any special and immunochemical staining for amyloid did not reveal amyloid deposition in the tumor. Our findings suggest that increased PiB uptake was not associated with amyloid in this instance.
• Spontaneously infarcted parotid tumours: MRI findings.

  Nobuo Kashiwagi; Tomoko Hyodo; Kazunari Ishii; Osamu Maenishi; Eisuke Enoki; Takaaki Chikugo; Tsurusaki Masakatsu; Yukinobu Yagyu; Mutsukazu Kitano; Noriyuki Tomiyama

  Dento maxillo facial radiology 48 (5) 20180382 - 20180382 2019/07 [Refereed]
   

  OBJECTIVES: To report MRI findings of spontaneous infarction in parotid tumours. METHODS: 14 patients (13 male, 1 female; mean age 73 years) with spontaneously infarcted parotid tumours were reviewed retrospectively. MR images were assessed for the location, the presence of synchronous parotid masses, margin characteristics, signal intensity on T1 and T2 weighted images, and internal architecture according to the distribution of T2 signal hyperintensity. RESULTS: 12 tumours were located in the parotid tail and 2 in the superficial lobe. Synchronous parotid masses were seen in four tumours, three of which were located in the ipsilateral parotid tail and one in the contralateral parotid tail. Seven tumours had well-defined margins and seven had ill-defined margins. The signal intensities on T1 weighted images were a mixture of high and intermediate in all cases; in 11 tumours, hyperintense areas were dominant. On T2 weighted images, all tumours also showed a mixture of high and intermediate signal intensities. Internal architectures on T2 weighted images were mosaic hyperintensity in three tumours, central hyperintensity in five, and multiseparated hyperintensity in six. CONCLUSIONS: Spontaneously infarcted parotid tumours were mostly located in the parotid tail and showed mixed signal intensities with predominant hyperintensity on T1 weighted images. Half of the tumours had ill-defined margins, and the internal architectures varied.
• Progression of logopenic aphasia to frontotemporal dementia in an amyloid β-negative and 18 F-THK-5351-positive patient.

  Masahiko Takaya; Kazunari Ishii; Isao Kubota; Osamu Shirakawa

  Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 19 (4) 399 - 401 1346-3500 2019/07 [Refereed]
  
• 心筋SPECTと冠動脈CTの融合画像作成における技術的注意点と対策について

  吉田 修平; 花岡 宏平; 坂口 健太; 又野 嘉枝子; 安田 昌和; 石井 一成

  日本心臓核医学会ニュースレター 日本心臓核医学会 21 (2) 85 - 85 1346-2733 2019/06
• Usefulness of respiratory-gated F-18-FDG PET/CT scan protocol in patients having positive myocardial F-18-FDG uptake

  Shota Watanabe; Kohei Hanaoka; Yusuke Shibata; Hayato Kaida; Kazunari Ishii

  NUCLEAR MEDICINE COMMUNICATIONS LIPPINCOTT WILLIAMS & WILKINS 40 (3) 235 - 241 0143-3636 2019/03 [Refereed]
   

  Objective The aim of this study were to estimate the influence of respiratory movement on the fluorine-18-fluorodeoxyglucose (F-18-FDG) PET/computed tomography (CT) imaging of patients having positive myocardial F-18-FDG uptake and to demonstrate an adequate respiratory-gated F-18-FDG PET/CT scan protocol. Materials and methods An anthropomorphic chest phantom containing a cardiac ventricle phantom was filled with an fluorine-18 solution and scanned in both a nonmoving state and a moving state with respiratory gating. In the nonmoving state, PET images were acquired in static mode (static PET), whereas in the moving state, PET images were acquired in a nongated mode (nongated PET), and in a gated mode (gated PET). The gated PET images were divided into 2-10 phases. The standardized uptake value (SUV)(nongated ratio) and SUVgated ratio (SUVnongated ratio or SUVgated ratio=SUVmean of nongated PET or gated PET/SUVmean of static PET) were calculated. In addition, nongated PET images and gated PET images were created from 12 sets of respiratory-gated clinical F-18-FDG PET/CT acquisitions. The clinical 12 gated PET data were divided into 2-8 phases. We measured SUVmax of cardiac volume data at each number of phases. Results In dividing into more than three phases, the SUVgated ratio remarkably improved. In dividing into more than five phases, rate of SUVmax improvement from nongated PET showed 5% in the analysis of clinical data. Conclusion For a F-18-FDG PET/CT scan for patients with having positive myocardial F-18-FDG uptake, a respiratory-gated PET protocol divided into five phases is recommended, to minimize the influence of internal motion on cardiac accumulation.
• 肺癌手術にて病理診断されたMultiple minute pulmonary meningothelial-like nodulesの1例

  和田 祐太郎; 松木 充; 土居 秀平; 鈴木 絢子; 沼本 勲男; 小田 晃義; 山田 穣; 兵頭 朋子; 任 誠雲; 甲斐田 勇人; 柳生 行伸; 細川 知紗; 小塚 健倫; 柏木 伸夫; 鶴崎 正勝; 今岡 いずみ; 細野 眞; 石井 一成; 村上 卓道; 榎木 英介

  Japanese Journal of Radiology (公社)日本医学放射線学会 37 (Suppl.) 40 - 40 1867-1071 2019/02
• Identification of prognostic factors to predict cognitive decline of patients with early Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative study.

  Takuya Yagi; Michio Kanekiyo; Junichi Ito; Ryoko Ihara; Kazushi Suzuki; Atsushi Iwata; Takeshi Iwatsubo; Ken Aoshima

  Alzheimer's & dementia (New York, N. Y.) 5 364 - 373 2019 

  INTRODUCTION: The objective of this study was to determine the factors including neuropsychological test performances and cerebrospinal fluid (CSF) biomarkers which can predict disease progression of early Alzheimer's disease (AD) in a Japanese population. METHODS: The group classification on early AD population in both Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and North American ADNI (NA-ADNI) was performed using the inclusion criteria including brain amyloid positivity on positron emission tomography or CSF. Participants with early AD from each cohort were stratified into two groups based on a cutoff 1.0 of Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) change at month 24 (m24): participants in "progress group" have CDR-SB change ≥ 1.0 and participants in "stable group" have CDR-SB change < 1.0. Then, we performed identification of prognostic factors from baseline items including neuropsychological scores (Assessment Scale-Cognitive Subscale[ADAS-cog 13], Mini-Mental State Examination (MMSE), CDR, FAQ, and Geriatric Depression Scale ), CSF markers (t-tau, p-tau, and beta-amyloid 1-42), vital signs (body weight, pulse rate, etc.,), by using two statistical approaches, Welch's t-test and simple linear regression by ordinary least squares. Comparisons between participants with J-ADNI and participants with NA-ADNI were also performed. RESULTS: Trends of CDR-SB changes were very similar between J-ADNI and NA-ADNI early AD population enrolled in this study. Baseline levels of CSF t-tau, p-tau, Mini-Mental State Examination, FAQ, and ADAS-cog13 were identified as prognostic factors in both J-ADNI and NA-ADNI. Based on a detailed subscale analysis on ADAS-cog13, four subscales (Q1: word recall, Q3: construction, Q4: delayed word recall, and Q8: word recognition) were identified as prognostic factors in both J-ADNI and NA-ADNI. DISCUSSION: Characterizing population with early AD can provide benefits for promoting efficiency in conducting AD clinical trials for disease-modifying treatments. Thus, implementing these prognostic factors into clinical trials may be potentially a good method to enrich participants with early AD who are suitable for evaluating treatment effects.
• FDG-PET/CTで集積を認めた心臓原発悪性リンパ腫の一例

  甲斐田 勇人; 山田 穣; 松久保 祐子; 花岡 宏平; 任 誠雲; 柳生 行伸; 細野 眞; 石井 一成

  核医学 (一社)日本核医学会 56 (1) 153 - 153 0022-7854 2019
• Regional dissociation between the cerebral blood flow and gray matter density alterations in idiopathic normal pressure hydrocephalous: results from SINPHONI-2 study

  Ryuichi Takahashi; Kazunari Ishii; Takahiko Tokuda; Madoka Nakajima; Takaharu Okada

  Neuroradiology Springer Science and Business Media {LLC} 61 (1) 37 - 42 0028-3940 2019/01 [Refereed]
   

  PURPOSE: The purpose of this study was to elucidate the specific regional cerebral blood flow (rCBF) alterations for idiopathic normal pressure hydrocephalus (iNPH) by comparing the proportional rCBF and gray matter change from those of a normal database at the same point of SPECT and MRI examinations. METHODS: Thirty subjects with iNPH underwent both CBF SPECT and MRI. After normalization, voxel-wise two-sample t tests between patients and 11 normal controls were conducted to compare the regional alteration in the gray matter density and rCBF. RESULTS: The rCBF reduction and the gray matter decrease were seen in almost similar regions surrounding Sylvian fissure, the left parietotemporal region and frontal lobes, whereas we did not find rCBF increase at the top of the high convexity, where the increase of the gray matter density was the highest (p < 0.05). CONCLUSION: Our study showed regional associations and dissociations between the relative gray matter density and rCBF in patients with iNPH.
• A Rare Case of 18F-FDG Uptake in an Ectopic Thyroid Carcinoma of the Anterior Middle Neck Lacking Thyroglossal Duct Remnants.

  Kaida H; Inui H; Chikugo T; Ishii K

  Case reports in oncology 12 (1) 157 - 163 2019/01 [Refereed]
  
• パーキンソン症候群に対するDAT Z-score画像の臨床応用

  高橋 竜一; 石井 一成; 樫林 哲雄; 丸本 浩平; 多々野 誠; 水田 英二

  臨床神経学 (一社)日本神経学会 58 (Suppl.) S213 - S213 0009-918X 2018/12 [Refereed]
  
• SPIOを用いた新しいリンパ節転移診断法

  村上幸祐; 鈴木彩子; 佐藤華子; 城玲央奈; 山本貴子; 大須賀拓真; 甲斐冴; 藤島理沙; 青木稚人; 葉宜慧; 貫戸明子; 高矢寿光; 小谷泰史; 中井英勝; 辻勲; 石井一成; 柏木伸夫; 佐藤隆夫; 榎木英介; 松村謙臣

  近畿大学医学雑誌 近畿大学医学会 43 (3-4) 17A - 17A 0385-8367 2018/12
• SRTM法を用いたアミロイドイメージングに対する空間分解能を損なわないノイズ低減アルゴリズムの検討

  山田 誉大; 木村 裕一; 根本 充貴; 坂田 宗之; 永岡 隆; 花岡 宏平; 甲斐田 勇人; 石井 一成

  核医学 (一社)日本核医学会 55 (Suppl.) S168 - S168 0022-7854 2018/11
• AI異常検知を用いたFDG-PET/CT上の頸胸部原発性・転移性病変の検出

  根本 充貴; 甲斐田 勇人; 田中 敦子; 牛房 和之; 山田 誉大; 木村 裕一; 花岡 宏平; 石井 一成

  核医学 (一社)日本核医学会 55 (Suppl.) S196 - S196 0022-7854 2018/11
• FDG PET/CTによる食道癌術前化学療法の予後解析

  甲斐田 勇人; 白石 治; 岩間 密; 加藤 寛章; 木村 豊; 花岡 宏平; 山田 穣; 北島 一宏; 細野 眞; 安田 卓司; 石井 一成

  核医学 (一社)日本核医学会 55 (Suppl.) S200 - S200 0022-7854 2018/11
• 心臓サルコイドーシスに対する呼吸同期PET/CT撮影の有効性

  渡邊 翔太; 花岡 宏平; 柴田 侑亮; 石井 一成

  核医学技術 (NPO)日本核医学技術学会 38 (予稿集) 399 - 399 0289-100X 2018/10
• The assessment of correlation and prognosis among 18F-FDG uptake parameters, Glut1, pStat1 and pStat3 in surgically resected non-small cell lung cancer patients.

  Hayato Kaida; Koichi Azuma; Akihiko Kawahara; Eiji Sadashima; Satoshi Hattori; Shinzo Takamori; Jun Akiba; Kiminori Fujimoto; Axel Rominger; Takamichi Murakami; Kazunari Ishii; Masatoshi Ishibashi

  Oncotarget 9 (62) 31971 - 31984 2018/08 [Refereed]
   

  Introduction: To assess the correlation among 18F-FDG uptake, Glut1, pStat1 and pStat3, and to investigate the relationship between the prognosis and 18F-FDG uptake and these molecular markers in surgically resected non-small cell lung cancer (NSCLC) patients. Results: Knockdown of Glut1 led to a significant increase in pStat1 expression. Glut1 expression positively correlated with the SUVmax, SUVmean, and TLG significantly (P<0.001). pStat3 expression negatively correlated with all PET parameters significantly (P<0.001). pStat1 had positive weak correlations with the SUVmax and SUVmean. All PET parameters and Glut1 were significantly associated with DFS (P<0.05). TLG, MTV, Glut1 and pStat1 were significantly associated with OS (P<0.05). Conclusion: pStat3 and Glut1 may be associated with 18F-FDG uptake mechanism. TLG, MTV, and Glut1 may be independent prognostic factors. Methods: The SUVmax, SUVmean, MTV and TLG of primary lesions were calculated in 140 patients. The expressions of Glut1 and Stat pathway proteins in NSCLC cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry. OS and DFS were evaluated by the Kaplan-Meier method. The difference in survival between subgroups was analyzed by log-rank test. The prognostic significance of clinicopathological, molecular and PET parameters was assessed by Cox proportional hazard regression analysis.
• Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials.

  Takeshi Iwatsubo; Atsushi Iwata; Kazushi Suzuki; Ryoko Ihara; Hiroyuki Arai; Kenji Ishii; Michio Senda; Kengo Ito; Takeshi Ikeuchi; Ryozo Kuwano; Hiroshi Matsuda; Chung-Kai Sun; Laurel A Beckett; Ronald C Petersen; Michael W Weiner; Paul S Aisen; Michael C Donohue

  Alzheimer's & dementia : the journal of the Alzheimer's Association 14 (8) 1077 - 1087 2018/08 

  INTRODUCTION: We conducted Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and compared the basic characteristics and progression profiles with those of ADNI in North America. METHODS: A total of 537 Japanese subjects with normal cognition, late amnestic mild cognitive impairment (LMCI), or mild Alzheimer's disease (AD) were enrolled using the same criteria as ADNI. Rates of changes in representative cognitive or functional measures were compared for amyloid positron emission tomography- or cerebrospinal fluid amyloid β(1-42)-positive LMCI and mild AD between J-ADNI and ADNI. RESULTS: Amyloid positivity rates were significantly higher in normal cognition of ADNI but at similar levels in LMCI and mild AD between J-ADNI and ADNI. Profiles of decline in cognitive or functional measures in amyloid-positive LMCI in J-ADNI (n = 75) and ADNI (n = 269) were remarkably similar, whereas those in mild AD were milder in J-ADNI (n = 73) compared with ADNI (n = 230). DISCUSSION: These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries.
• Semi-quantitative dopamine transporter standardized uptake value in comparison with conventional specific binding ratio in [123I] FP-CIT single-photon emission computed tomography (DaTscan)

  Yuichi Wakabayashi; Ryuichi Takahashi; Tomonori Kanda; Feibi Zeng; Munenobu Nogami; Kazunari Ishii; Takamichi Murakami

  NEUROLOGICAL SCIENCES SPRINGER-VERLAG ITALIA SRL 39 (8) 1401 - 1407 1590-1874 2018/08 [Refereed]
   

  We developed a new analytical method to quantify the dopamine transporter (DAT) radiation dose in the striatum on [I-123] FP-CIT single-photon emission computed tomography (SPECT). This method is based on the dopamine transporter standardized uptake value (DaTSUV). The purpose of this study was to compare DaTSUV with the classical specific binding ratio (SBR) in the discrimination of dopaminergic neurodegenerative diseases (dNDD) from non-dNDD.Seventy-seven consecutive patients who underwent DaTscan were included. Patients were divided into a dNDD group (n = 44; 24 men, 20 women; median age 73 years) and a non-dNDD group (n = 33; 14 men, 19 women; median age 75 years) based on their clinical diagnoses. The relationship between each method was evaluated by Pearson's correlation coefficient. Differences in SBR and DaTSUV in each group were evaluated by t test. Pairwise comparison of receiver operating characteristic (ROC) curve analysis was performed to compare the discriminating abilities of each method according to the standard error of the area under the curve (AUC). A value of p < 0.05 was considered statistically significant.There was a significant strong correlation between DaTSUV and SBR (r = 0.910 [95% CI = 0.862-0.942], p < 0.001). The dNDD group showed significantly lower SBR (3.48 [1.25-7.91] vs 6.58 [3.81-11.1], p < 0.001) and DaTSUV (4.91 [1.59-13.6] vs 8.61 [2.29-15.6], p < 0.001) than the non-dNDD group. The discriminating ability of SBR (AUC = 0.918) was significantly higher than that of DaTSUV (AUC = 0.838, p = 0.0176).DaTSUV has a good correlation with SBR, but it could not exceed SBR for discriminating dNDD from non-dNDD.
• MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report.

  Nobuo Kashiwagi; Shin Ichi Nakatsuka; Takamichi Murakami; Eisuke Enoki; Kazuhiro Yamamoto; Katsuyuki Nakanishi; Takaaki Chikugo; Yoshitaka Kurisu; Masatomo Kimura; Tomoko Hyodo; Akio Tsukabe; Takahide Kakigi; Yasuhiko Tomita; Kazunari Ishii; Yoshifumi Narumi; Yukinobu Yagyu; Noriyuki Tomiyama

  Dento maxillo facial radiology 47 (5) 20170218 - 20170218 0250-832X 2018/07 [Refereed]
   

  OBJECTIVES: To report MR imaging features of mammary analogue secretory carcinoma (MASC) and acinic cell carcinoma (AciCC) of the salivary gland based on the latest version of the World Health Organization (WHO) 2017 classification of head and neck tumours. METHODS: MR images in 4 patients with MASC and 4 with AciCC were reviewed for margin characteristics, the presence of pathological cervical nodes, the presence of a cystic component and interface between cystic and solid component, signal intensity of the cystic components on T1 weighted images, and signal intensity of the solid component on T1 and T2 weighted images. RESULTS: All the MASCs and AciCCs had well-defined boundaries, and 1 AciCC had pathological nodes. All 4 MASCs presented as predominantly cystic tumours with papillary projection of the solid component. All 4 AciCCs presented as solid tumours. The signal intensity of the cystic components on T1 weighted images was entirely hyperintense in 2, and partly hyperintense demonstrating fluid-fluid level in 2. In all the MASCs, the signal intensity of the solid components on T1 weighted images was intermediate. In the AciCCs, the signal intensity of the solid components on T1 weighted images was high in 2 tumours and intermediate in 2. The signal intensity of the solid components on T2 weighted images varied from low to high in both MSACs and AciCCs. CONCLUSIONS: All 4 MASCs had a large cystic component, including areas of high signal intensity on T1 weighted images. The solid component appeared as a papillary projection into the cystic component. All 4 AciCCs presented as solid tumours, 2 of which showed high signal intensity on T1 weighted images.
• The correlation between striatal and cortical binding ratio of 11C-PiB-PET in amyloid-uptake-positive patients

  Julia Sauerbeck; Kazunari Ishii; Chisa Hosokawa; Hayato Kaida; Franziska T. Scheiwein; Kohei Hanaoka; Axel Rominger; Matthias Brendel; Peter Bartenstein; Takamichi Murakami

  Annals of Nuclear Medicine Springer Science and Business Media {LLC} 32 (6) 398 - 403 0914-7187 2018/07 [Refereed]
   

  PURPOSE: In subjects with amyloid deposition, striatal accumulation of 11C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer's disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential (BPND). METHODS: Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected. These subjects included 34 AD, 26 mild cognitive impairment, 2 frontotemporal lobar degeneration, 2 Parkinson's disease, 5 dementia with Lewy bodies, and 4 undefined diagnosis patients. Individual BPND images were produced from the dynamic data of the PiB-PET study, and voxel-based analyses were performed to estimate the correlations between striatal and other regional cortical BPND measures. RESULTS: There were highly significant correlations between striatal and prefrontal BPND, with the highest correlation being demonstrated in left Brodmann area 11. We found that almost all of the high cortical BPND values correlated with striatal BPND values, with the exception of the occipital cortex with low correlation. CONCLUSION: Our study demonstrated positive correlations in amyloid deposits between the striatum and other cortical areas with functional and anatomical links. The amyloid distribution in the brain is not random, but spreads following the functional and anatomical connections.
• 【頸部・顔面の救急疾患の画像診断】唾液腺,甲状腺

  柏木 伸夫; 藤原 良平; 甲斐田 勇人; 鶴崎 正勝; 石井 一成

  画像診断 (株)学研メディカル秀潤社 38 (8) 795 - 804 0285-0524 2018/06 

  ＜文献概要＞唾液腺および甲状腺の救急疾患で,放射線科医が関与するCT検査の主な役割は,病変の広がりや気道への影響の評価である.ただし,各々の疾患のCT所見に精通することは,診断の精度向上や治療方針決定に寄与しうる.加えて血管造影,MRI, 核医学検査の果たす役割や適応について, 当該診療科にアドバイスできる知見をもつことも,放射線科医として重要である.
• A case of TAFRO syndrome

  鈴木絢子; 沼本勲男; 松木充; 小田晃義; 柳生行伸; 小塚健倫; 石井一成; 榎木英介; 村上卓道

  臨床放射線 金原出版(株) 63 (5) 553 - 557 0009-9252 2018/05 

  78歳男。腹部鈍痛を主訴とした。近医にて血液検査で炎症反応高値、汎血球減少、ALP上昇、肝機能障害、腎機能障害を認めた。腹部骨盤CTでは体腔液貯留、肝・副腎腫大、椎体・仙骨・腸骨・大腿骨の骨髄濃度の上昇を認め、腎盂腎炎疑いで4週間加療するも発熱と腹水増加を呈した。紹介受診時には体温38℃で、血液生化学検査所見の改善はみられなかった。胸部・腹部骨盤CTでは胸腹水増加、全身浮腫増悪、全身の多発リンパ腫大を認めた。骨髄生検では原発性骨髄線維症grade MF1相当であった。鼠径リンパ節生検ではhyaline-vascular typeのCastleman病類似の組織像を認めた。TAFRO症候群と診断した。
• Tau accumulation in two patients with frontotemporal lobe degeneration showing different types of aphasia using F-18-THK-5351 positron emission tomography: a case report

  Masahiko Takaya; Kazunari Ishii; Chisa Hosokawa; Kazumasa Saigoh; Osamu Shirakawa

  INTERNATIONAL PSYCHOGERIATRICS CAMBRIDGE UNIV PRESS 30 (5) 641 - 646 1041-6102 2018/05 [Refereed]
   

  Tau deposits in Alzheimer's disease and corticobasal syndrome have been reported using F-18-THK-5351 positron emission tomography (PET). To our knowledge, our study is the first to demonstrate tau deposits in patients with frontotemporal lobe degeneration (FTLD), using 18F-THK-5351 PET. This case report presents two patients, both of whom showed positive Tau deposition using 18F-THK-5351 PET. One patient was diagnosed with semantic variant primary progressive aphasia (PPA) and the other diagnosed with logopenic variant PPA. Our results suggest an association in the pathology of Alzheimer's disease, corticobasal syndrome, and FTLD, and could plan more effective clinical care in advance.
• Impact to Z-score Mapping of Hyperacute Stroke Images by Computed Tomography in Adaptive Statistical Iterative Reconstruction

  Watanabe Shota; Sakaguchi Kenta; Hosono Makoto; Ishii Kazunari; Murakami Takamichi; Ichikawa Katsuhiro

  Japanese Journal of Radiological Technology Japanese Society of Radiological Technology 74 (4) 375 - 381 0369-4305 2018/04 

  The purpose of this study was to evaluate the effect of a hybrid-type iterative reconstruction method on Z-score mapping of hyperacute stroke in unenhanced computed tomography (CT) images. We used a hybrid-type iterative reconstruction [adaptive statistical iterative reconstruction (ASiR)] implemented in a CT system (Optima CT660 Pro advance, GE Healthcare). With 15 normal brain cases, we reconstructed CT images with a filtered back projection (FBP) and ASiR with a blending factor of 100% (ASiR100%). Two standardized normal brain data were created from normal databases of FBP images (FBP-NDB) and ASiR100% images (ASiR-NDB), and standard deviation (SD) values in basal ganglia were measured. The Z-score mapping was performed for 12 hyperacute stroke cases by using FBP-NDB and ASiR-NDB, and compared Z-score value on hyperacute stroke area and normal area between FBP-NDB and ASiR-NDB. By using ASiR-NDB, the SD value of standardized brain was decreased by 16%. The Z-score value of ASiR-NDB on hyperacute stroke area was significantly higher than FBP-NDB (p<0.05). Therefore, the use of images reconstructed with ASiR100% for Z-score mapping had potential to improve the accuracy of Z-score mapping.

• Usefulness of the convexity apparent hyperperfusion sign in 123I-iodoamphetamine brain perfusion SPECT for the diagnosis of idiopathic normal pressure hydrocephalus.

  Takuma Ohmichi; Masaki Kondo; Masahiro Itsukage; Hidetaka Koizumi; Shigenori Matsushima; Nagato Kuriyama; Kazunari Ishii; Etsuro Mori; Kei Yamada; Toshiki Mizuno; Takahiko Tokuda

  Journal of neurosurgery 130 (2) 398 - 405 0022-3085 2018/03 [Refereed]
   

  OBJECTIVE: The gold standard for the diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is the CSF removal test. For elderly patients, however, a less invasive diagnostic method is required. On MRI, high-convexity tightness was reported to be an important finding for the diagnosis of iNPH. On SPECT, patients with iNPH often show hyperperfusion of the high-convexity area. The authors tested 2 hypotheses regarding the SPECT finding: 1) it is relative hyperperfusion reflecting the increased gray matter density of the convexity, and 2) it is useful for the diagnosis of iNPH. The authors termed the SPECT finding the convexity apparent hyperperfusion (CAPPAH) sign. METHODS: Two clinical studies were conducted. In study 1, SPECT was performed for 20 patients suspected of having iNPH, and regional cerebral blood flow (rCBF) of the high-convexity area was examined using quantitative analysis. Clinical differences between patients with the CAPPAH sign (CAP) and those without it (NCAP) were also compared. In study 2, the CAPPAH sign was retrospectively assessed in 30 patients with iNPH and 19 healthy controls using SPECT images and 3D stereotactic surface projection. RESULTS: In study 1, rCBF of the high-convexity area of the CAP group was calculated as 35.2–43.7 ml/min/100 g, which is not higher than normal values of rCBF determined by SPECT. The NCAP group showed lower cognitive function and weaker responses to the removal of CSF than the CAP group. In study 2, the CAPPAH sign was positive only in patients with iNPH (24/30) and not in controls (sensitivity 80%, specificity 100%). The coincidence rate between tight high convexity on MRI and the CAPPAH sign was very high (28/30). CONCLUSIONS: Patients with iNPH showed hyperperfusion of the high-convexity area on SPECT; however, the presence of the CAPPAH sign did not indicate real hyperperfusion of rCBF in the high-convexity area. The authors speculated that patients with iNPH without the CAPPAH sign, despite showing tight high convexity on MRI, might have comorbidities such as Alzheimer’s disease.
• High performance plasma amyloid-β biomarkers for Alzheimer's disease.

  Akinori Nakamura; Naoki Kaneko; Victor L Villemagne; Takashi Kato; James Doecke; Vincent Doré; Chris Fowler; Qiao-Xin Li; Ralph Martins; Christopher Rowe; Taisuke Tomita; Katsumi Matsuzaki; Kenji Ishii; Kazunari Ishii; Yutaka Arahata; Shinichi Iwamoto; Kengo Ito; Koichi Tanaka; Colin L Masters; Katsuhiko Yanagisawa

  Nature 554 (7691) 249 - 254 0028-0836 2018/02 [Refereed]
   

  To facilitate clinical trials of disease-modifying therapies for Alzheimer's disease, which are expected to be most efficacious at the earliest and mildest stages of the disease, supportive biomarker information is necessary. The only validated methods for identifying amyloid-β deposition in the brain-the earliest pathological signature of Alzheimer's disease-are amyloid-β positron-emission tomography (PET) imaging or measurement of amyloid-β in cerebrospinal fluid. Therefore, a minimally invasive, cost-effective blood-based biomarker is desirable. Despite much effort, to our knowledge, no study has validated the clinical utility of blood-based amyloid-β markers. Here we demonstrate the measurement of high-performance plasma amyloid-β biomarkers by immunoprecipitation coupled with mass spectrometry. The ability of amyloid-β precursor protein (APP)669-711/amyloid-β (Aβ)1-42 and Aβ1-40/Aβ1-42 ratios, and their composites, to predict individual brain amyloid-β-positive or -negative status was determined by amyloid-β-PET imaging and tested using two independent data sets: a discovery data set (Japan, n = 121) and a validation data set (Australia, n = 252 including 111 individuals diagnosed using 11C-labelled Pittsburgh compound-B (PIB)-PET and 141 using other ligands). Both data sets included cognitively normal individuals, individuals with mild cognitive impairment and individuals with Alzheimer's disease. All test biomarkers showed high performance when predicting brain amyloid-β burden. In particular, the composite biomarker showed very high areas under the receiver operating characteristic curves (AUCs) in both data sets (discovery, 96.7%, n = 121 and validation, 94.1%, n = 111) with an accuracy approximately equal to 90% when using PIB-PET as a standard of truth. Furthermore, test biomarkers were correlated with amyloid-β-PET burden and levels of Aβ1-42 in cerebrospinal fluid. These results demonstrate the potential clinical utility of plasma biomarkers in predicting brain amyloid-β burden at an individual level. These plasma biomarkers also have cost-benefit and scalability advantages over current techniques, potentially enabling broader clinical access and efficient population screening.
• High performance plasma amyloid-β biomarkers for Alzheimer’s disease

  Kazunari Ishii

  Nature 0028-0836 2018/02 [Refereed]
  
• 神経核内封入体病の1例

  沼本勲男; 松木充; 福井秀行; 若林雄一; 日高正二郎; 渡口真史; 藤谷哲也; 山川美帆; 兵頭朋子; 山田穣; 任誠雲; 甲斐田勇人; 柳生行伸; 柏木伸夫; 細川知紗; 小塚健倫; 鶴崎正勝; 今岡いずみ; 細野眞; 石井一成; 村上卓道

  Japanese Journal of Radiology (公社)日本医学放射線学会 36 (Suppl.) 27 - 27 1867-1071 2018/02
• 孤立性内臓動脈解離のCT所見

  福井秀行; 松木充; 任誠雲; 甲斐田勇人; 柳生行伸; 小塚健倫; 細川知紗; 熊野正士; 柏木伸夫; 鶴崎正勝; 今岡いずみ; 細野眞; 石井一成; 村上卓道

  Japanese Journal of Radiology (公社)日本医学放射線学会 36 (Suppl.) 34 - 34 1867-1071 2018/02
• Correlations between dual-phase 18F-FDG uptake and clinicopathologic and biological markers in predicting the aggressiveness of breast cancer

  Hayato Kaida; Koichi Azuma; Uhi Toh; Akihiko Kawahara; Eiji Sadashima; Satoshi Hattori; Jun Akiba; Nobuhiro Tahara; Axel Rominger; Kazunari Ishii; Takamichi Murakami; Masatoshi Ishibashi

  Hellenic Journal of Nuclear Medicine P.Ziti and Co 21 (1) 35 - 42 1790-5427 2018/01 [Refereed]
   

  Objective: To assess the correlations between dual-phase uorine-18 uorodeoxyglucose (18F-FDG) uptake and clinicopathological and immunohistochemical prognostic factors in patients with surgically resected breast cancer stage I-III. Subjects and Methods: We retrospectively analyzed the cases of 105 patients. We calculated the maximum standardized uptake value (SUVmax) at 85min (SUV1), SUVmax at 125min (SUV2) and the retention index [RI]. Spearman's rank correlation test, the Kruskal-Wallis test and receiver operating characteristic (ROC) analysis were performed to assess the association between 18F-FDG uptake and the clinicopathological and immunohistochemical factors: glucose transporter-1 (Glut-1), estrogen receptor alpha (ERα), ERβ, progesterone receptor (PR), human epidermal growth factor 2 (Her2), mammalian target of rapamycin (mTOR), and P70S6kinase (P70S6). Results: The SUV1 and SUV2 values were correlated with Glut-1, pathological tumor size, ERα negativity, and pathological stage (all P values were < 0.05), but not with mTOR, P70S6, ERβ, PR, Her2 or other factors. The SUV1 and SUV2 in the triple negative subtype were signi-cantly higher than those of the hormone receptor-positive subtype (P< 0.05). The RI was associated with pathological tumor size alone. In the ROC analysis of Glut-1, the areas under the curve for SUV1 and SUV2 were signicantly larger than for RI (SUV1, P=0.032, SUV2, P=0.022). Conclusion: Glucose transporter-1, estrogen receptor alpha negativity and nuclear grade might affect the high 18F-FDG uptake in breast cancer. The SUVmax might be more useful than the RI for predicting the Glut-1 expression and the aggressiveness of breast cancer.
• Relationship Between Body Mass Index, ApoE4 Status, and PET-Based Amyloid and Neurodegeneration Markers in Amyloid-Positive Subjects with Normal Cognition or Mild Cognitive Impairment.

  Janusch Blautzik; Sebastian Kotz; Matthias Brendel; Julia Sauerbeck; Franziska Vettermann; Yaroslav Winter; Peter Bartenstein; Kazunari Ishii; Axel Rominger

  Journal of Alzheimer's disease : JAD 65 (3) 781 - 791 1387-2877 2018 [Refereed]
   

  Body weight loss in late-life is known to occur at a very early stage of Alzheimer's disease (AD). Apolipoprotein E4 (ApoE4) represents a major genetic risk factor for AD and is linked to an increased cortical amyloid-β (Aβ) accumulation. Since the relationship between body weight, ApoE4, and AD pathology is poorly investigated, we aimed to evaluate whether ApoE4 allelic status modifies the association of body mass index (BMI) with markers of AD pathology. A total of 368 Aβ-positive cognitively healthy or mild cognitive impaired subjects had undergone [18F]-AV45-PET, [18F]-FDG-PET, and T1w-MRI examinations. Composite cortical [18F]-AV45 uptake and [18F]-FDG uptake in posterior cingulate cortex were calculated as surrogates of cortical Aβ load and glucose metabolism, respectively. Multiple linear regressions were performed to assess the relationships between these PET biomarkers with BMI, present cognitive performance, and cognitive changes over time. Multivariate analysis of covariance was conducted to test for statistical differences between ApoE4/BMI categories on the PET markers and cognitive scores. In carriers of the ApoE4 allele only, BMI was inversely associated with cortical amlyoid load (β= -0.193, p < 0.005) and recent cognitive decline (β= -0.209, p < 0.05), and positively associated with cortical glucose metabolism in an AD-vulnerable region (β= 0.145, p < 0.05). ApoE4/BMI category analyses demonstrated lower Aβ load, higher posterior cingulate glucose metabolism, improved cognitive performance, and lower progression of cognitive decline in obese ApoE4 carriers. The effect of ApoE4 in promoting the accumulation of cortical amyoid, which may itself be a driver for weight loss, may be moderated by altering leptin signaling in the hypothalamus.
• Incidental Case of Relapsing Polychondritis Detected by 18F-FDG PET/CT.

  Hayato Kaida; Kazunari Ishii; Soichiro Hanada; Yuji Tohda; Takamichi Murakami

  Clinical nuclear medicine LIPPINCOTT WILLIAMS & WILKINS 43 (1) 25 - 27 0363-9762 2018/01 [Refereed]
   

  A 78-year-old man had fever, persistent wheezing, and serum C-reactive protein elevation. Malignant lymphoma was suspected because of mediastinal lymph nodes swelling on CT and soluble interleukin 2 receptor elevation. Symmetric F-FDG uptake in the tracheobronchial tree and bilateral auricles was observed on PET/CT. He was finally diagnosed as having relapsing polychondritis by auricular cartilage biopsy. F-FDG PET/CT may have crucial role in evaluating the extent of inflammation and deciding the biopsy site of relapsing polychondritis.
• Serotonin Selective Reuptake Inhibitor Treatment Improves Cognition and Grey Matter Atrophy but not Amyloid Burden During Two-Year Follow-Up in Mild Cognitive Impairment and Alzheimer's Disease Patients with Depressive Symptoms.

  Matthias Brendel; Julia Sauerbeck; Sonja Greven; Sebastian Kotz; Franziska Scheiwein; Janusch Blautzik; Andreas Delker; Oliver Pogarell; Kazunari Ishii; Peter Bartenstein; Axel Rominger

  Journal of Alzheimer's disease : JAD 65 (3) 793 - 806 1387-2877 2018 [Refereed]
   

  Late-life depression, even when of subsyndromal severity, has shown strong associations with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical studies have suggested that serotonin selective reuptake inhibitors (SSRIs) can attenuate amyloidogenesis. Therefore, we aimed to investigate the effect of SSRI medication on amyloidosis and grey matter volume in subsyndromal depressed subjects with MCI and AD during an interval of two years. 256 cognitively affected subjects (225 MCI/ 31 AD) undergoing [18F]-AV45-PET and MRI at baseline and 2-year follow-up were selected from the ADNI database. Subjects with a positive depression item (DEP(+); n = 73) in the Neuropsychiatric Inventory Questionnaire were subdivided to those receiving SSRI medication (SSRI(+); n = 24) and those without SSRI treatment (SSRI(-); n = 49). Longitudinal cognition (Δ-ADAS), amyloid deposition rate (standardized uptake value, using white matter as reference region (SUVRWM), and changes in grey matter volume were compared using common covariates. Analyses were performed separately in all subjects and in the subgroup of amyloid-positive subjects. Cognitive performance in DEP(+)/SSRI(+) subjects (Δ-ADAS: -5.0%) showed less deterioration with 2-year follow-up when compared to DEP(+)/SSRI(-) subjects (Δ-ADAS: +18.6%, p < 0.05), independent of amyloid SUVRWM at baseline. With SSRI treatment, the progression of grey matter atrophy was reduced (-0.9% versus -2.7%, p < 0.05), notably in fronto-temporal cortex. A slight trend towards lower amyloid deposition rate was observed in DEP(+)/SSRI(+) subjects versus DEP(+)/SSRI(-). Despite the lack of effect to amyloid PET, SSRI medication distinctly rescued the declining cognitive performance in cognitively affected patients with depressive symptoms, and likewise attenuated grey matter atrophy.
• Pareidolic illusions of a patient with suspected late-onset, sleep-related epilepsy

  Masahiko Takaya; Masahiko Atsumi; Kazunari Ishii; Osamu Shirakawa

  PSYCHOGERIATRICS WILEY 17 (6) 495 - 497 1346-3500 2017/11 [Refereed]
  
• Enlargement of the infraorbital canal following Caldwell-Luc surgery.

  Hideyuki Fukui; Nobuo Kashiwagi; Takamichi Murakami; Yoshiyuki Watanabe; Tomoko Hyodo; Kazunari Ishii; Miho Yamakawa; Hirito Takahashi; Noriyuki Tomiyama

  Japanese journal of radiology 35 (9) 532 - 538 2017/09 [Refereed]
   

  OBJECTIVES: The infraorbital canal (IOC), which runs in the roof of the maxillary sinus, is a useful anatomical landmark for the infraorbital nerve (ION) on computed tomography (CT) images. Enlargement of the IOC on CT images is thought to be a pathological state that usually affects the ION. However, we have frequently observed enlargement of the IOC in patients with a history of radical surgery of the maxillary sinus: so-called Caldwell-Luc (CL) surgery. In this study, the size of the IOC of the maxillary sinus was compared between patients with a history of CL surgery (post-CL IOCs) and those with no history of CL surgery (control IOCs). METHODS: A total of 347 consecutive patients who underwent facial CT from January 2014 to October 2014 for various indications were evaluated. After excluding groove-type IOCs and IOCs with pathological lesions that could affect their diameters, 47 post-CL IOCs in 26 patients were finally compared with 504 control IOCs in 252 patients. To evaluate IOC size, the short-axis diameter of the IOC was measured on a reconstructed coronal image at the level of the posterior pole of the eyeball. RESULTS: The short-axis diameters of the post-CL IOCs and control IOCs were 3.0 ± 0.6 and 1.4 ± 0.3 mm, respectively (p < 0.005). CONCLUSIONS: The short-axis diameters of post-CL IOCs are significantly enlarged (approximately double the diameter) compared to those of control IOCs.
• Cost-effectiveness analysis of shunt surgery for idiopathic normal pressure hydrocephalus based on the SINPHONI and SINPHONI-2 trials

  Kazunari Ishii

  Acta Neurochirurgica 0001-6268 2017/06 [Refereed]
  
• Inter-rater variability of visual interpretation and comparison with quantitative evaluation of C-11-PiB PET amyloid images of the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) multicenter study

  Tomohiko Yamane; Kenji Ishii; Muneyuki Sakata; Yasuhiko Ikari; Tomoyuki Nishio; Kazunari Ishii; Takashi Kato; Kengo Ito; Michio Senda

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 44 (5) 850 - 857 1619-7070 2017/05 [Refereed]
   

  The aim of this study was to assess the inter-rater variability of the visual interpretation of C-11-PiB PET images regarding the positivity/negativity of amyloid deposition that were obtained in a multicenter clinical research project, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI). The results of visual interpretation were also compared with a semi-automatic quantitative analysis using mean cortical standardized uptake value ratio to the cerebellar cortex (mcSUVR).A total of 162 C-11-PiB PET scans, including 45 mild Alzheimer's disease, 60 mild cognitive impairment, and 57 normal cognitive control cases that had been acquired as J-ADNI baseline scans were analyzed. Based on visual interpretation by three independent raters followed by consensus read, each case was classified into positive, equivocal, and negative deposition (ternary criteria) and further dichotomized by merging the former two (binary criteria).Complete agreement of visual interpretation by the three raters was observed for 91.3% of the cases (Cohen kappa = 0.88 on average) in ternary criteria and for 92.3% (kappa = 0.89) in binary criteria. Cases that were interpreted as visually positive in the consensus read showed significantly higher mcSUVR than those visually negative (2.21 +/- 0.37 vs. 1.27 +/- 0.09, p < 0.001), and positive or negative decision by visual interpretation was dichotomized by a cut-off value of mcSUVR = 1.5. Significant positive/negative associations were observed between mcSUVR and the number of raters who evaluated as positive (rho = 0.87, p < 0.0001) and negative (rho = -0.85, p < 0.0001) interpretation. Cases of disagreement among raters showed generally low mcSUVR.Inter-rater agreement was almost perfect in C-11-PiB PET scans. Positive or negative decision by visual interpretation was dichotomized by a cut-off value of mcSUVR = 1.5. As some cases of disagreement among raters tended to show low mcSUVR, referring to quantitative method may facilitate correct diagnosis when evaluating images of low amyloid deposition.
• Increased Pittsburgh Compound-B Accumulation in the Subcortical White Matter of Alzheimer's Disease Brain

  Wakabayashi Y; Ishii K; Hosokawa C; Hyodo T

  Kobe J Med Sci 62 (5) 136 - 141 2017/05 [Refereed]
  
• Inter-rater variability of visual interpretation and comparison with quantitative evaluation of C-11-PiB PET amyloid images of the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) multicenter study

  Tomohiko Yamane; Kenji Ishii; Muneyuki Sakata; Yasuhiko Ikari; Tomoyuki Nishio; Kazunari Ishii; Takashi Kato; Kengo Ito; Michio Senda

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 44 (5) 850 - 857 1619-7070 2017/05 [Refereed]
   

  The aim of this study was to assess the inter-rater variability of the visual interpretation of C-11-PiB PET images regarding the positivity/negativity of amyloid deposition that were obtained in a multicenter clinical research project, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI). The results of visual interpretation were also compared with a semi-automatic quantitative analysis using mean cortical standardized uptake value ratio to the cerebellar cortex (mcSUVR). A total of 162 C-11-PiB PET scans, including 45 mild Alzheimer's disease, 60 mild cognitive impairment, and 57 normal cognitive control cases that had been acquired as J-ADNI baseline scans were analyzed. Based on visual interpretation by three independent raters followed by consensus read, each case was classified into positive, equivocal, and negative deposition (ternary criteria) and further dichotomized by merging the former two (binary criteria). Complete agreement of visual interpretation by the three raters was observed for 91.3% of the cases (Cohen kappa = 0.88 on average) in ternary criteria and for 92.3% (kappa = 0.89) in binary criteria. Cases that were interpreted as visually positive in the consensus read showed significantly higher mcSUVR than those visually negative (2.21 +/- 0.37 vs. 1.27 +/- 0.09, p < 0.001), and positive or negative decision by visual interpretation was dichotomized by a cut-off value of mcSUVR = 1.5. Significant positive/negative associations were observed between mcSUVR and the number of raters who evaluated as positive (rho = 0.87, p < 0.0001) and negative (rho = -0.85, p < 0.0001) interpretation. Cases of disagreement among raters showed generally low mcSUVR. Inter-rater agreement was almost perfect in C-11-PiB PET scans. Positive or negative decision by visual interpretation was dichotomized by a cut-off value of mcSUVR = 1.5. As some cases of disagreement among raters tended to show low mcSUVR, referring to quantitative method may facilitate correct diagnosis when evaluating images of low amyloid deposition.
• Increased Pittsburgh Compound-B Accumulation in the Subcortical White Matter of Alzheimer's Disease Brain.

  Yuichi Wakabayashi; Kazunari Ishii; Chisa Hosokawa; Tomoko Hyodo; Hayato Kaida; Minoru Yamada; Yukinobu Yagyu; Masakatsu Tsurusaki; Takenori Kozuka; Kazuro Sugimura; Takamichi Murakami

  The Kobe journal of medical sciences 62 (5) E136-E141 - E141 0023-2513 2017/03 [Refereed]
   

  Using 11C-Pittsburgh compound B (PiB)-PET and MRI volume data, we investigated whether white matter (WM) PiB uptake in Alzheimer's disease (AD) brain is larger than that of cortical PiB uptake-negative (PiB-negative) brain. Forty-five subjects who underwent both PiB-PET and MRI were included in the study (32 AD patients with cortical PiB-positive and 13 cortical amyloid -negative patients). Individual areas of gray matter (GM) and WM were segmented, then regional GM and WM standard uptake value ratio (SUVR) normalized to cerebellar GM with partial volume effects correction was calculated. Three regional SUVRs except WM in the centrum semiovale in the AD group were significantly larger than those in the PiB-negative groups. Frontal WM SUVR in the AD group vs frontal WM SUVR in the PiB-negative group was 2.57 ± 0.55 vs 1.64 ± 0.22; parietal, 2.50 ± 0.52 vs 1.74 ± 0.22; posterior cingulate, 2.84 ± 0.59 vs 1.73 ± 0.22; and WM in the centrum semiovale, 2.21 ± 0.53 vs 2.42 ± 0.36, respectively. We found that PiB uptake in AD brain is significantly larger than that in PiB-negative brain in the frontal, parietal and posterior cingulate subcortical WM, except in the centrum semiovale.
• The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitis.

  Silvia Morbelli; Javier Arbizu; Jan Booij; Ming-Kai Chen; Gael Chetelat; Donna J Cross; Mehdi Djekidel; Alexander Drzezga; Ozgul Ekmekcioglu; Valentina Garibotto; Swen Hesse; Kazunari Ishii; Lida Jafari; Adriaan A Lammertsma; Ian Law; Dana Mathews; Satoshi Minoshima; Karina Mosci; Marco Pagani; Sabina Pappata; Daniel Hillel Silverman; Alberto Signore; Elsmarieke Van De Giessen; Victor Villemagne; Henryk Barthel

  European journal of nuclear medicine and molecular imaging SPRINGER 44 (3) 353 - 357 1619-7070 2017/03 [Refereed]
  
• Erratum to: The need of standardization and of large clinical studies in an emerging indication of [18 F]FDG PET: the autoimmune encephalitis.

  Silvia Morbelli; Javier Arbizu; Jan Booij; Ming-Kai Chen; Gael Chetelat; Donna J Cross; Mehdi Djekidel; Alexander Drzezga; Ozgul Ekmekcioglu; Valentina Garibotto; Swen Hesse; Kazunari Ishii; Lida Jafari; Adriaan A Lammertsma; Ian Law; Dana Mathews; Satoshi Minoshima; Karina Mosci; Marco Pagani; Sabina Pappata; Daniel Hillel Silverman; Alberto Signore; Elsmarieke Van De Giessen; Victor Villemagne; Henryk Barthel

  European journal of nuclear medicine and molecular imaging SPRINGER 44 (3) 559 - 560 1619-7070 2017/03 [Refereed]
  
• The need of standardization and of large clinical studies in an emerging indication of [F-18]FDG PET: the autoimmune encephalitis

  Silvia Morbelli; Javier Arbizu; Jan Booij; Ming-Kai Chen; Gael Chetelat; Donna J. Cross; Mehdi Djekidel; Alexander Drzezga; Ozgul Ekmekcioglu; Valentina Garibotto; Swen Hesse; Kazunari Ishii; Lida Jafari Saraf; Adriaan A. Lammertsma; Ian Law; Dana Mathews; Satoshi Minoshima; Karina Mosci; Marco Pagani; Sabina Pappata; Daniel Hillel Silverman; Alberto Signore; Elsmarieke Van de Giessen; Victor Villemagne; Henryk Barthel

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 44 (3) 353 - 357 1619-7070 2017/03 [Refereed]
  
• Disease duration: the key to accurate CSF tap test in iNPH

  Kazunari Ishii

  Acta Neurologica Scandinavica Wiley 135 (2) 189 - 196 0001-6314 2017/02 [Refereed]
  
• Clinical application of apparent diffusion coefficient mapping in voxel-based morphometry in the diagnosis of Alzheimer's disease

  H. Takahashi; K. Ishii; N. Kashiwagi; Y. Watanabe; H. Tanaka; T. Murakami; N. Tomiyama

  CLINICAL RADIOLOGY W B SAUNDERS CO LTD 72 (2) 108 - 115 0009-9260 2017/02 [Refereed]
   

  AIM: To evaluate the performance of apparent diffusion coefficient (ADC) mapping compared with voxel-based morphometry and to demonstrate the clinical usefulness of ADC mapping in the diagnosis of Alzheimer's disease (AD). MATERIALS AND METHODS: The study population comprised 31 patients with AD (group A) and 24 patients without dementia (group B) who underwent three-dimensional (3D) T1weighted imaging (WI) and two- dimensional (2D) echo-planar diffusion-weighted imaging (DWI) at 3 T. The volume and ADC of the regional grey matter (GM) in the bilateral hippocampi, precunei, and the anterior and posterior cingulate gyri were calculated using a voxelbased method for automatic segmentation of brain structures. The significance of intergroup differences in each volume and ADC of all regional GM was tested using analysis of variance (ANOVA) with Bonferroni correction. Intergroup regional GM differences in each volume and ADC were evaluated using statistical parametric mapping (SPM). RESULTS: In group A, the volumes of the precunei (mean value: group A/B = 18.93/21.48 cm(3)) and the anterior cingulate gyri (mean value: group A/B = 6.1/7.81 cm(3)) were significantly less than in group B (p < 0.05). The ADC in group A was significantly larger than that in group B in the bilateral hippocampi (mean value: group A/B = right 1020.79x10(6)/ 877.23x10(-6) mm(2)/s; left 1072.89x10(-6)/900.2x10(-6) mm(2)/s) and posterior cingulate gyri (mean value: group A/B = 1006.77x10-(6)/876.88x10(-6) mm(2)/s; p < 0.05). SPM showed that the areas of increased ADC were more extensive than the areas of decreased volume in the bilateral hippocampi, precunei, and posterior cingulate gyri in group A, compared with those in group B (p < 0.001). CONCLUSION: Evaluation of ADC mapping can quantify changes in brain water diffusivity and may improve the performance of automatic morphometric diagnosis of AD. 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
• Neural Basis of Apathy in Patients with Amnestic Mild Cognitive Impairment.

  Hiroaki Kazui; Ryuichi Takahashi; Yuki Yamamoto; Kenji Yoshiyama; Hideki Kanemoto; Yukiko Suzuki; Shunsuke Sato; Shingo Azuma; Takashi Suehiro; Eku Shimosegawa; Kazunari Ishii; Toshihisa Tanaka

  Journal of Alzheimer's disease : JAD IOS PRESS 55 (4) 1403 - 1416 1387-2877 2017 [Refereed]
   

  BACKGROUND: Although apathy is associated with damage to the frontal and temporal lobes in Alzheimer's disease (AD), the crucial regions for apathy in patients with amnestic mild cognitive impairment (aMCI) are unknown. OBJECTIVE: To identify brain regions associated with apathy in aMCI patients. METHODS: The subjects of this study were 98 aMCI patients who were entered in our dementia registry between March 1, 2009 and April 30, 2015 and who satisfied our criteria for aMCI. The association between the apathy score of the Neuropsychiatric Inventory and regional gray matter volume was analyzed using voxel-based morphometry. The association between apathy score and regional cerebral blood flow (rCBF) measured with single photon emission computed tomography (SPECT) was analyzed using Statistical Parametric Mapping. RESULTS: The aMCI patients were classified into aMCI with and without "SPECT images suggestive of AD" (aMCI-AD+ and aMCI-AD-, respectively) based on the Z-score summation analysis method. In aMCI-AD+ (n = 31), apathy was significantly and negatively correlated with gray matter volume in the right caudate nucleus and with rCBF in five regions (left posterior-medial frontal lobe, right superior frontal lobe, bilateral culmen-fusiform gyri, and left occipital lobe). In aMCI-AD-(n = 67), apathy was significantly and negatively correlated with gray matter volumes in five regions but it was not correlated with rCBF in any regions. CONCLUSION: In patients with a high probability of being in the aMCI stage of AD, apathy was associated with atrophy of the right caudate nucleus and hypoperfusion in the frontal, temporal and occipital lobes.
• Regional differences in amyloid deposition between 11C-PiB PET positive patients with and without elevated striatal amyloid uptake.

  Scheiwein FT; Ishii K; Hosokawa C; Kaida H; Hyodo T; Hanaoka K; Brendel M; Bartenstein B; Rominger A; Murakami

  J Alzheimers Dis Parkinsonism 7 317  2017 [Refereed]
  
• Validation of a New Imaging Technique Using the Glucose Metabolism to Amyloid Deposition Ratio in the Diagnosis of Alzheimer's Disease

  Ryuichi Takahashi; Kazunari Ishii; Kazumasa Yokoyama

  CURRENT ALZHEIMER RESEARCH BENTHAM SCIENCE PUBL LTD 14 (2) 161 - 168 1567-2050 2017 [Refereed]
   

  Objective: Alzheimer' disease (AD) is characterized by increase of cortical amyloid deposition in prodromal stage and subsequent decrease of cerebral glucose metabolism as disease progresses. The present study introduces the voxel-wise metabolism to amyloid deposits ratio (MAR) image and to evaluate its reliability for the diagnosis of AD. Methods: Consecutive one-hundred and forty-three subjects with AD and 181 normal subjects who underwent both F-18-FDG PET and F-18-florbetapir (AV-45) PET at baseline were included to this study from the database of Alzheimer's disease neuroimaging initiative (ADNI). After normalizing to a standard stereotactic space, the MAR image was created by dividing each FDG-PET image by corresponding AV-45 PET image using with voxel-wise inter-image computation. We examined voxel wise comparison in the MAR images between AD subjects and normal subjects and compared the diagnostic performances between the MAR image and FDG-PET and AV-45 image. Results: In the voxel wise comparison, the MAR images of AD subjects exhibited severe and extensive decrease compared with normal subjects in the affected region in both FDG-PET and AV-45, especially in the precuneus /posterior cingulate. The highest t-value was equivalent to FDG-PET and the voxel extent was much greater than the other images. In the ROI analysis, the diagnostic accuracies were 82.6% (sensitivity: 86.7%, specificity: 79.5%), 80.7% (sensitivity: 77%, specificity: 83.4%), and 78.8% (sensitivity: 75.2%, specificity: 81.5%) for the MAR image, FDG-PET, and AV-45, respectively. AUC for the MAR image was 0.904 (95% CI: 0.867-0.942), and was larger than those for FDG-PET (AUC: 0.884, 95% CI: 0.843-0.926), and AV-45 (AUC: 0.847, 95% CI: 0.798-0.897). Conclusion: MAR image reflected not only amyloid deposition but the cerebral glucose metabolisms and successfully classified the subjects with AD. These data suggest that the MAR image might be a more proper appropriate diagnostic marker for AD reflecting cerebral metabolisms and amyloid deposition.
• 認知症診断における機能画像(PET,SPECT)の限界と留意点

  石井一成

  老年精神医学雑誌 (株)ワールドプランニング 28 (増刊I) 100 - 105 0915-6305 2017/01 

  核医学検査法PET、SPECTの認知症診断における限界と留意点について、以下のポイントに絞って解説した。(1)早期アルツハイマー病(AD)におけるFDG-PET検査の限界・留意点、(2)レビー小体型認知症(DLB)の鑑別診断における脳血流SPECT検査、MIBG心臓交感神経シンチグラフィー、ドパミントランスポーターイメージング検査(DaT scan)の限界・留意点、(3)画像統計解析の留意点。(著者抄録)
• One-year outcome in patients with idiopathic normal-pressure hydrocephalus: comparison of lumboperitoneal shunt to ventriculoperitoneal shunt

  Kazunari Ishii

  Journal of Neurosurgery 0022-3085 2016/12 [Refereed]
   

  OBJECTIVE Idiopathic normal pressure hydrocephalus (iNPH) is treated with cerebrospinal fluid shunting, and implantation of a ventriculoperitoneal shunt (VPS) is the current standard treatment. The objective of this study was to compare the efficacy and safety of VPSs and lumboperitoneal shunts (LPSs) for patients with iNPH. METHODS The authors conducted a prospective multicenter study of LPS use for patients with iNPH. Eighty-three patients with iNPH (age 60 to 85 years) who presented with ventriculomegaly and high-convexity and medial subarachnoid space tightness on MR images were recruited from 20 neurological or neurosurgical centers in Japan between March 1, 2010, and October 19, 2011. The primary outcome was the modified Rankin Scale (mRS) score 1 year after surgery, and the secondary outcome included scores on the iNPH grading scale (iNPHGS). A previously conducted VPS cohort study with the same inclusion criteria and primary and secondary end points was used as a historical control. RESULTS The proportion of patients who achieved a favorable outcome (i.e., improvement of at least 1 point in their mRS score) was 63% (95% CI 51%–73%) and was comparable to values reported with VPS implantation (69%, 95% CI 59%–78%). Using the iNPHGS, the 1-year improvement rate was 75% (95% CI 64%–84%) and was comparable to the rate found in the VPS study (77%, 95% CI 68%–84%). The proportion of patients experiencing serious adverse events (SAEs) and non-SAEs did not differ significantly between the groups at 1 year after surgery (SAEs: 19 [22%] of 87 LPS patients vs 15 [15%] of 100 VPS patients, p = 0.226; non-SAEs: 24 [27.6%] LPS patients vs 20 [20%] VPS patients, p = 0.223). However, shunt revisions were more common in LPS-treated patients than in VPS-treated patients (6 [7%] vs 1 [1%]). CONCLUSIONS The efficacy and safety rates for LPSs with programmable valves are comparable to those for VPSs for the treatment of patients with iNPH. Despite the relatively high shunt failure rate, an LPS can be the treatment of choice because of its minimal invasiveness and avoidance of brain injury.
• Estimation of activity of administered 18F-fluorodeoxyglucose by measurement of the dose equivalent rate on the right temporal region of the head.

  Kenta Sakaguchi; Makoto Hosono; Tomomi Imamura; Naomi Takahara; Misa Hayashi; Yuko Yakushiji; Kazunari Ishii; Tatsuro Uto; Takamichi Murakami

  EJNMMI physics 3 (1) 28 - 28 2197-7364 2016/12 [Refereed]
   

  BACKGROUND: Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) is now a routine procedure for the management of cancer patients. Intravenous administration of FDG is sometimes halted due to troubles. In such cases, estimations of the FDG dosage injected prior to halting administration may be helpful. We have established a method of estimating the activity of FDG to patients on the basis of the dose equivalent rate on the surface of the right temporal region of the head. The correlation of actual administered dosage with independent variables, such as the dose equivalent rate on the right temporal region of the head, age, sex, and body weight, was analyzed using multiple regression analysis to obtain linear, quadratic, and cubic regression equations. RESULTS: When entering independent variables, the cubic regression equation could be used to estimate an administered dosage with an accuracy of ±10 % for 62 % of all patients and ±20 % for 90 % of all patients. CONCLUSIONS: We conclude that this method is useful for estimating the administered dosage from the dose equivalent rate on the temporal region of the head.
• 治る認知症を見逃さない

  石井一成

  レジデント (株)医学出版 9 (12) 102 - 109 2016/12
• Diagnostic imaging for idiopathic normal pressure hydrocephalus

  石井一成

  老年精神医学雑誌 (株)ワールドプランニング 27 (11) 1171 - 1175 0915-6305 2016/11 

  特発性正常圧水頭症(iNPH)の大多数はdisproportionately enlarged subarachnoid-space hydrocephalus(DESH)であり、その画像の特徴的な脳室拡大、シルビウス裂開大、高位円蓋部・正中部の脳溝狭小化をとらえることが画像診断のポイントとなる。iNPH患者は高齢者が多く他の変性疾患との併存もあり得るので、アルツハイマー病などの併存を判定するのに脳血流SPECTが有用である。(著者抄録)
• The correlation between FDG uptake and biological molecular markers in pancreatic cancer patients

  Hayato Kaida; Koichi Azuma; Akihiko Kawahara; Masafumi Yasunaga; Yuhei Kitasato; Satoshi Hattori; Tomoki Taira; Hiroki Ureshino; Masayoshi Kage; Kazunari Ishii; Takamichi Murakami; Masatoshi Ishibashi

  EUROPEAN JOURNAL OF RADIOLOGY ELSEVIER IRELAND LTD 85 (10) 1804 - 1810 0720-048X 2016/10 [Refereed]
   

  Purpose: We examined whether fluorine-18 fluorodeoxyglucose (FDG) uptake is related to the mammalian target of rapamycin (mTOR) signal pathway and its related proteins in pancreatic cancer patients. Methods: We retrospectively studied 53 pancreatic cancer patients who underwent FDG positron emission tomography (PET) or FDG PET/CT, and complete curative surgical resection. The SUV max, the tumor to nontumor activity of pancreas [T/N (P)] ratio and the T/N of liver [T/N (L)] ratio were calculated. The expressions of glucose transporter-1( Glut-1) and mTOR pathway proteins in pancreas cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry using monoclonal antibodies for Glut-1, epidermal growth factor receptor (EGFR), mTOR, p70S6kinase (p70S6) and S6 ribosomal protein (S6). Results: The expressions of Glut-1, EGFR and p70S6 were significantly correlated with the SUV max, T/N (P) ratio and T/N (L) ratio. The expressions of mTOR and S6 were not correlated with all parameters. The expression of Glut-1 was positively correlated with the expressions of EGFR and p70S6, but not with mTOR or S6. S6 was positively correlated with p70S6. Conclusions: Glut-1, EGFR and p70S6 expressions are associated with the FDG uptake mechanism of pancreatic cancer. FDG uptake may predict the levels of EGFR and p70S6 expressions, and FDG uptake reflects glucose metabolism and cancer progression. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
• The usefulness of brain perfusion SPECT for differential diagnosis of dementia

  石井一成

  老年精神医学雑誌 (株)ワールドプランニング 27 (9) 934 - 940 0915-6305 2016/09 

  認知症診断における画像検査の役割は大きく、とりわけアルツハイマー病を含めた変性疾患の早期診断・鑑別診断における核医学検査の有用性は非常に大きい。それぞれの疾患特異的な血流低下パターンがあり、その所見を見いだして鑑別を行う。(著者抄録)
• Disability risk or unimproved symptoms following shunt surgery in patients with idiopathic normal-pressure hydrocephalus: post hoc analysis of SINPHONI-2

  Kazunari Ishii

  Journal of Neurosurgery 0022-3085 2016/07 [Refereed]
   

  OBJECTIVEThe study aim was to assess the influence of presurgical clinical symptom severity and disease duration on outcomes of shunt surgery in patients with idiopathic normal-pressure hydrocephalus (iNPH). The authors also evaluated the cerebrospinal fluid tap test as a predictor of improvements following shunt surgery.METHODSEighty-three patients (45 men and 38 women, mean age 76.4 years) underwent lumboperitoneal shunt surgery, and outcomes were evaluated until 12 months following surgery. Risks for poor quality of life (Score 3 or 4 on the modified Rankin Scale [mRS]) and severe gait disturbance were evaluated at 3 and 12 months following shunt surgery, and the tap test was also conducted. Age-adjusted and multivariate relative risks were calculated using Cox proportional-hazards regression.RESULTSOf 83 patients with iNPH, 45 (54%) improved by 1 point on the mRS and 6 patients (7%) improved by ≥ 2 points at 3 months following surgery. At 12 months after surgery, 39 patients (47%) improved by 1 point on the mRS and 13 patients (16%) improved by ≥ 2 points. On the gait domain of the iNPH grading scale (iNPHGS), 36 patients (43%) improved by 1 point and 13 patients (16%) improved by ≥ 2 points at 3 months following surgery. Additionally, 32 patients (38%) improved by 1 point and 14 patients (17%) by ≥ 2 points at 12 months following surgery. In contrast, 3 patients (4%) and 2 patients (2%) had worse symptoms according to the mRS or the gait domain of the iNPHGS, respectively, at 3 months following surgery, and 5 patients (6%) and 3 patients (4%) had worse mRS scores and gait domain scores, respectively, at 12 months after surgery. Patients with severe preoperative mRS scores had a 4.7 times higher multivariate relative risk (RR) for severe mRS scores at 12 months following surgery. Moreover, patients with severe gait disturbance prior to shunt surgery had a 46.5 times greater multivariate RR for severe gait disturbance at the 12-month follow-up. Patients without improved gait following the tap test had multivariate RRs for unimproved gait disturbance of 7.54 and 11.2 at 3 and 12 months following surgery, respectively. Disease duration from onset to shunt surgery was not significantly associated with postoperative symptom severity or unimproved symptoms.CONCLUSIONSPatients with iNPH should receive treatment before their symptoms become severe in order to achieve an improved quality of life. However, the progression of symptoms varies between patients so specific timeframes are not meaningful. The authors also found that tap test scores accurately predicted shunt efficacy. Therefore, indications for shunt surgery should be carefully assessed in each patient with iNPH, considering the relative risks and benefits for that person, including healthy life expectancy.
• Report of a nationwide survey on actual administered radioactivities of radiopharmaceuticals for diagnostic reference levels in Japan

  Hiroshi Watanabe; Kazunari Ishii; Makoto Hosono; Etsuko Imabayashi; Koichiro Abe; Masayuki Inubushi; Kazuko Ohno; Yasuhiro Magata; Kinya Ono; Kei Kikuchi; Kei Wagatsuma; Tadashi Takase; Kyoko Saito; Yasuyuki Takahashi

  ANNALS OF NUCLEAR MEDICINE SPRINGER 30 (6) 435 - 444 0914-7187 2016/07 [Refereed]
   

  The optimization of medical exposure is one of the major issues regarding radiation protection in the world, and The International Committee of Radiological Protection and the International Atomic Energy Agency recommend establishing diagnostic reference levels (DRLs) as tools for dose optimization. Therefore, the development of DRLs based on the latest survey has been required for nuclear medicine-related societies and organizations. This prompted us to conduct a nationwide survey on the actual administered radioactivity to adults for the purpose of developing DRLs in nuclear medicine.A nationwide survey was conducted from November 25, 2014 to January 16, 2015. The questionnaire was sent to all of the 1249 nuclear medicine facilities in Japan, and the responses were collected on a website using an answered form.Responses were obtained from 516 facilities, for a response rate of 41 %. 75th percentile of Tc-99m-MDP and Tc-99m-HMDP: bone scintigraphy, Tc-99m-HM-PAO, Tc-99m-ECD and I-123-IMP: cerebral blood flow scintigraphy, Tc-99m-Tetrofosmin, Tc-99m-MIBI and Tl-201-Cl; myocardial perfusion scintigraphy and F-18-FDG: oncology PET (in-house-produced or delivery) in representative diagnostic nuclear medicine scans were 932, 937, 763, 775, 200, 831, 818, 180, 235 and 252, respectively. More than 90 % of the facilities were within the range of 50 % from the median of these survey results in representative diagnostic nuclear medicine facilities in Japan. Responses of the administered radioactivities recommended by the package insert, texts and guidelines such as 740 MBq (Tc-99m-MDP and Tc-99m-HMDP: bone scintigraphy), 740 MBq (Tc-99m-ECD and Tc-99m-HM-PAO: cerebral blood flow scintigraphy) and 740 MBq (Tc-99m-Tetrofosmin and Tc-99m-MIBI: myocardial perfusion scintigraphy), etc. were numerous. The administered activity of many radiopharmaceuticals of bone scintigraphy (Tc-99m-MDP and Tc-99m-HMDP), cerebral blood flow scintigraphy (Tc-99m-HM-PAO) and myocardial perfusion scintigraphy (Tc-99m-Tetrofosmin and Tc-99m-MIBI), etc. were within the range of the EU DRLs and almost none of the administered radioactivity in Japan exceeded the upper limit of SNMMI standard administered radioactivity.This survey indicated that the administered radioactivity in diagnostic nuclear medicine in Japan had been in the convergence zone and nuclear medicine facilities in Japan show a strong tendency to adhere to the texts and guidelines. Furthermore, the administered radioactivities in Japan were within the range of variation of the EU and the SNMMI administered radioactivities.
• Imaging of metastases from breast cancer to uncommon sites: a pictorial review

  Masafumi Toguchi; Mitsuru Matsuki; Isao Numoto; Masakatsu Tsurusaki; Izumi Imaoka; Kazunari Ishii; Rikiya Yamashita; Yuki Inada; Shuichi Monzawa; Hisato Kobayashi; Takamichi Murakami

  JAPANESE JOURNAL OF RADIOLOGY SPRINGER 34 (6) 400 - 408 1867-1071 2016/06 [Refereed]
   

  There are three types of breast cancer recurrence which can occur after initial treatment: local, regional, and distant. Distant metastases are more frequent than local and regional recurrences. It usually occurs several years after the primary breast cancer, although it is sometimes diagnosed at the same time as the primary breast cancer. Although the common distant metastases are bone, lung and liver, breast cancer has the potential to metastasize to almost any region of the body. Early detection and treatment of distant metastases improves the prognosis, therefore radiologists and clinicians should recognize the possibility of metastasis from breast cancer and grasp the imaging characteristics. In this report, we demonstrate the imaging characteristics of metastases from breast cancer to uncommon sites.
• TOPICS from ANM：レビー小体型認知症における局所ブドウ糖代謝低下はアミロイド沈着に依存しない

  石井一成; 細川知紗; 兵頭朋子; 坂口健太; 宇佐美公男; 島元健次; 山添 穰; 村上卓道

  臨床核医学 49 (6) 89 - 90 2016/06 [Refereed]
  
• Pretherapeutic FDG heterogeneity in tumors can predict local control in oropharyngeal cancer patients undergoing intensity-modulated radiation therapy

  Hanaoka Kohei; Hosono Makoto; Tatebe Hitoshi; Ishikawa Kazuki; Monzen Hajime; Ishii Kazunari; Nishimura Yasumasa

  JOURNAL OF NUCLEAR MEDICINE 57 0161-5505 2016/05 [Refereed]
  
• Cognitive impairment before changes appear on [18F]-fluoro-D-glucose positron emission tomography images in a patient with possible early-stage cerebellar-predominant multiple system atrophy

  Masahiko Takaya; Masahiko Atsumi; Tomoyuki Hirose; Kazunari Ishii; Osamu Shirakawa

  PSYCHOGERIATRICS WILEY 16 (3) 216 - 221 1346-3500 2016/05 [Refereed]
   

  Multiple system atrophy (MSA) is a sporadic, rapidly progressive neurodegenerative disorder characterized by autonomic dysfunction combined with parkinsonism or cerebellar ataxia. Patients with MSA typically suffer from cognitive disorders and rapid eye movement sleep behaviour disorder. F-18-fluorodeoxyglucose-positron emission tomography is used to assess MSA. However, the relationship between the clinical features and findings on F-18-fluorodeoxyglucose-positron emission tomography in patients with MSA has not yet been investigated. Here we report a case of possible early-stage cerebellar-type MSA. We concluded that cerebellar-type MSA or other factors, such as rapid eye movement sleep behaviour disorder or obstructive sleep apnoea cognitive impairment, could appear before changes are visible on F-18-fluorodeoxyglucose-positron emission tomography images. Additionally, we concluded that the cognitive impairment could derive from cerebellar-type MSA itself, not from other factors such as rapid eye movement sleep behaviour disorder or sleep apnoea syndrome.
• Prediction of Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers.

  Kenichi Ota; Naoya Oishi; Kengo Ito; Hidenao Fukuyama

  Journal of Alzheimer's disease : JAD 52 (4) 1385 - 401 2016/04 

  BACKGROUND: Prediction of progression to Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI) is challenging because of its heterogeneity. OBJECTIVE: To evaluate a stratification method on different cohorts and to investigate whether stratification in amnestic MCI could improve prediction accuracy. METHODS: We identified 80 and 79 patients with amnestic MCI from different cohorts, respectively. They underwent baseline magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans. We performed hierarchical clustering with three imaging biomarkers: Brain volume on MRI, left hippocampus grey matter loss on MRI, and left inferior temporal gyrus glucose hypometabolism on FDG-PET. Regions-of-interest for biomarkers were defined by the Automated Anatomical Labeling atlas. We performed voxel-wise statistical parametric mapping to explore differences between clusters in patterns of grey matter loss and glucose hypometabolism. We compared time to progression using an interval-censored parametric model. We evaluated predictive performance using logistic regression. RESULTS: Similar clusters were found in different cohorts. MCI1 had the healthiest biomarker profile of cognitive performance and imaging biomarkers. MCI2 had cognitive performance and MRI measures intermediate between those of nonconverters and converters. MCI3 showed the severest reduction in brain volume and left hippocampal atrophy. MCI4 showed remarkable glucose hypometabolism in the left inferior temporal gyrus, and also demonstrated significant decreases in most cognitive scores, including non-memory functions. MCI4 showed the highest risk for progression. The prediction of progression of MCI2 especially benefited from the stratification. CONCLUSION: Stratification with imaging biomarkers in amnestic MCI can be a good approach for improving predictive performance.
• Bladder recovery relates with increased mid-cingulate perfusion after shunt surgery in idiopathic normal-pressure hydrocephalus: a single-photon emission tomography study

  Ryuji Sakakibara; Yoshitaka Uchida; Kazunari Ishii; Masaaki Hashimoto; Masaaki Ishikawa; Hiromitsu Kazui; Tatsuya Yamamoto; Tomoyuki Uchiyama; Fuyuki Tateno; Masahiko Kishi; Yohei Tsuyusaki; Yosuke Aiba; Hiromi Tateno; Takeki Nagao; Hitoshi Terada; Tsutomu Inaoka

  INTERNATIONAL UROLOGY AND NEPHROLOGY SPRINGER 48 (2) 169 - 174 0301-1623 2016/02 [Refereed]
   

  It is reported that severe bladder disorder in idiopathic normal-pressure hydrocephalus (iNPH) is predicted by right frontal hypoperfusion. However, it is not known whether bladder recovery is predicted by brain perfusion change after shunt surgery. To address this issue, we compared bladder and brain function before and after shunt surgery in iNPH.We enrolled 75 patients in the study. Before and 12 months after shunt surgery, we analyzed brain perfusion by SPECT and bladder disorder by a specialized grading scale. The scale consisted of grade 0, none; grade 1, urinary urgency and frequency; grade 2, urinary incontinence 1-3 times a week; grade 3, urinary incontinence > daily; and grade 4, loss of bladder control. More than one grade improvement is defined as improvement, and more than one grade decrement as worsening; otherwise no changes.Comparing before and after surgery, in the bladder-no-change group (32 cases) there was an increase in blood flow which is regarded as reversal of enlargement in the Sylvian fissure and lateral ventricles (served as control). In contrast, in the bladder-improved group (32 cases) there was an increase in bilateral mid-cingulate, parietal, and left frontal blood flow (p < 0.05). In the bladder-worsened group (11 cases) no significant blood flow change was observed.The present study showed that after shunt surgery, bladder recovery is related with mid-cingulate perfusion increase in patients with iNPH. The underlying mechanism might be functional restoration of the mid-cingulate that normally inhibits the micturition reflex.
• アルツハイマー病の診断にどのような画像検査を推奨するか？

  石井一成

  画像診断ガイドライン2016年度版 95 - 97 2016 [Refereed]
  
• 特発性正常圧水頭症にはどのような画像検査が有用か？

  石井一成

  画像診断ガイドライン2016年度版 98 - 99 2016 [Refereed]
  
• Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease.

  Kenichi Ota; Naoya Oishi; Kengo Ito; Hidenao Fukuyama

  Journal of neuroscience methods 256 168 - 83 2015/12 

  BACKGROUND: The choice of biomarkers for early detection of Alzheimer's disease (AD) is important for improving the accuracy of imaging-based prediction of conversion from mild cognitive impairment (MCI) to AD. The primary goal of this study was to assess the effects of imaging modalities and brain atlases on prediction. We also investigated the influence of support vector machine recursive feature elimination (SVM-RFE) on predictive performance. METHODS: Eighty individuals with amnestic MCI [40 developed AD within 3 years] underwent structural magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans at baseline. Using Automated Anatomical Labeling (AAL) and LONI Probabilistic Brain Atlas (LPBA40), we extracted features representing gray matter density and relative cerebral metabolic rate for glucose in each region of interest from the baseline MRI and FDG-PET data, respectively. We used linear SVM ensemble with bagging and computed the area under the receiver operating characteristic curve (AUC) as a measure of classification performance. We performed multiple SVM-RFE to compute feature ranking. We performed analysis of variance on the mean AUCs for eight feature sets. RESULTS: The interactions between atlas and modality choices were significant. The main effect of SVM-RFE was significant, but the interactions with the other factors were not significant. COMPARISON WITH EXISTING METHOD: Multimodal features were found to be better than unimodal features to predict AD. FDG-PET was found to be better than MRI. CONCLUSIONS: Imaging modalities and brain atlases interact with each other and affect prediction. SVM-RFE can improve the predictive accuracy when using atlas-based features.
• Performance of C-11-Pittsburgh Compound B PET Binding Potential Images in the Detection of Amyloid Deposits on Equivocal Static Images

  Chisa Hosokawa; Kazunari Ishii; Yuichi Kimura; Tomoko Hyodo; Makoto Hosono; Kenta Sakaguchi; Kimio Usami; Kenji Shimamoto; Yuzuru Yamazoe; Takamichi Murakami

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 56 (12) 1910 - 1915 0161-5505 2015/12 [Refereed]
   

  The goal of this study was to clarify whether binding potential (BP) images using C-11-Pittsburgh compound B (C-11-PiB) and dynamic PET can reliably detect cortical amyloid deposits for patients whose C-11-PiB PET static images are ambiguous and whether visual ratings are affected by white matter retention. Methods: Static and BP images were constructed for 85 consecutive patients with cognitive impairment after C-11-PiB dynamic PET. Cortical uptake was visually assessed as positive, negative, or equivocal for both types of images. Quantitatively, the standardized uptake value ratio (SUVR) from the static image, the nondisplaceable BP from the dynamic image for mean gray matter uptake, and the ratio of gray matter uptake to white matter retention were compared among C-11-PiB-positive, C-11-PiB-equivocal, and C-11-PiB-negative groups. Results: Forty-three scans were visually assessed as C-11-PiB-positive in both the static and the BP images. Ten scans were C-11-PiB-equivocal in the static images. In 8 of them, the BP images were C-11-PiB-positive, whereas the other 2 were C-11-PiB-equivocal. Thirty-two scans were assessed as C-11-PiB-negative in the static images. In the BP images, 4 were C-11-PiB-positive and 2 were C-11-PiB-equivocal. The mean gray matter uptake of C-11-PiB in SUVR and nondisplaceable BP, respectively, showed statistically significant differences among the C-11-PiB-positive, C-11-PiB-equivocal, and C-11-PiB-negative groups. The ratio of gray matter uptake to white matter retention was lower in the BP images than static images from the C-11-PiB-negative and C-11-PiB-equivocal groups, whereas it was higher in the C-11-PiB-positive group. Conclusion: C-11-PiB PET BP images can clarify visual interpretation of clinical static C-11-PiB-equivocal images by reducing the interference of nonspecific white matter retention. We conclude that C-11-PiB-equivocal PET findings on static images reflect cortical amyloid deposits, which can be verified using BP images. Furthermore, quantitative assessments, such as SUVR and nondisplaceable BP, are of no use for correctly rating equivocal visual findings.
• Contrast enhancement of intracranial lesions at 1.5 T: comparison among 2D spin echo, black-blood (BB) Cube, and BB Cube-FLAIR sequences

  SungWoon Im; Ryuichiro Ashikaga; Yukinobu Yagyu; Tetsuya Wakayama; Mitsuharu Miyoshi; Tomoko Hyodo; Izumi Imaoka; Seishi Kumano; Kazunari Ishii; Takamichi Murakami

  EUROPEAN RADIOLOGY SPRINGER 25 (11) 3175 - 3186 0938-7994 2015/11 [Refereed]
   

  The purpose of this study was to investigate the usefulness of T1W black-blood Cube (BB Cube) and T1W BB Cube fluid-attenuated inversion recovery (BB Cube-FLAIR) sequences for contrast-enhanced brain imaging, by evaluating flow-related artefacts, detectability, and contrast ratio (CR) of intracranial lesions among these sequences and T1W-SE. Phantom studies were performed to determine the optimal parameters of BB Cube and BB Cube-FLAIR. A clinical study in 23 patients with intracranial lesions was performed to evaluate the usefulness of these two sequences for the diagnosis of intracranial lesions compared with the conventional 2D T1W-SE sequence. The phantom study revealed that the optimal parameters for contrast-enhanced T1W imaging were TR/TE = 500 ms/minimum in BB Cube and TR/TE/TI = 600 ms/minimum/300 ms in BB Cube-FLAIR imaging. In the clinical study, the degree of flow-related artefacts was significantly lower in BB Cube and BB Cube-FLAIR than in T1W-SE. Regarding tumour detection, BB Cube showed the best detectability; however, there were no significant differences in CR among the sequences. At 1.5 T, contrast-enhanced BB Cube was a better imaging sequence for detecting brain lesions than T1W-SE or BB Cube-FLAIR. aEuro cent Cube is a single-slab 3D FSE imaging sequence. aEuro cent We applied a black-blood (BB) imaging technique to T1W Cube. aEuro cent At 1.5 T, contrast-enhanced T1W BB Cube was valuable for detecting brain lesions.
• Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial.

  Hiroaki Kazui; Masakazu Miyajima; Etsuro Mori; Masatsune Ishikawa

  The Lancet. Neurology 14 (6) 585 - 94 2015/06 

  BACKGROUND: Lumboperitoneal shunt surgery has the potential to alleviate symptoms of normal pressure hydrocephalus but the benefits of such surgery have not been tested in a randomised trial. The aim of this trial was to determine the safety and efficacy of the lumboperitoneal shunt surgery for this disorder. METHODS: For the open-label randomised SINPHONI-2 trial, eligible participants (60-85 years of age) with idiopathic normal pressure hydrocephalus, with ventriculomegaly, and tightness of the high-convexity and medial subarachnoid spaces on MRI, were recruited from 20 neurological and neurosurgical centres in Japan. Enrolled participants were randomly assigned in a 1:1 ratio according to a random code generated by the trial statistician, with a permuted block design (using a block size of 4 or 6) within each centre, to receive lumboperitoneal shunt surgery within 1 month after randomisation, or to surgery postponed for 3 months. Patients and assessors were not masked to treatment assignment. The primary endpoint was favourable outcome, defined as an improvement of one point or more on the modified Rankin scale (mRS) at 3 months after randomisation, analysed by intention to treat, and the main secondary endpoint was the same outcome 12 months after surgery, analysed per protocol. This trial is registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), number UMIN000002730. FINDINGS: Between March 1, 2010, and Oct 19, 2011, 93 patients with idiopathic normal pressure hydrocephalus were enrolled and randomly assigned to the immediate treatment group (n=49) or the postponed treatment group (n=44). More patients in the immediate treatment group than in the postponed treatment group had an improvement of one point or more on the mRS at 3 months: 32 (65%) of 49 in the immediate group vs 2 (5%) of 44 in the postponed group (difference 61% [95% CI 42-68]; p<0·0001). The number of patients who had an improvement of one point or more on the mRS at 12 months after surgery was similar between the two groups: 30 (67%) of 45 patients in the immediate group vs 22 (58%) of 38 in the postponed group (difference 9% [95% CI -14 to 31]; p=0·496). The proportions of patients with serious adverse events did not differ significantly between the groups during the 3 months post-randomisation (7 [15%] of 46 in the immediate group vs 1 [2%] of 42 in the postponed group; p=0·060). During the 12 months after surgery, 19 (22%) of 87 patients had serious adverse events, the most common of which was cerebral infarction (six patients [7%]). INTERPRETATION: Our results suggest that lumboperitoneal shunt surgery might be beneficial for patients with idiopathic normal pressure hydrocephalus and, if these findings are confirmed in larger studies, could be a first-line treatment option for this disease. FUNDING: Johnson & Johnson and Nihon Medi-Physics.
• Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial

  Kazunari Ishii

  The Lancet Neurology Lancet Publishing Group 14 (6) 585 - 94 1474-4422 2015/06 [Refereed]
   

  BACKGROUND: Lumboperitoneal shunt surgery has the potential to alleviate symptoms of normal pressure hydrocephalus but the benefits of such surgery have not been tested in a randomised trial. The aim of this trial was to determine the safety and efficacy of the lumboperitoneal shunt surgery for this disorder. METHODS: For the open-label randomised SINPHONI-2 trial, eligible participants (60-85 years of age) with idiopathic normal pressure hydrocephalus, with ventriculomegaly, and tightness of the high-convexity and medial subarachnoid spaces on MRI, were recruited from 20 neurological and neurosurgical centres in Japan. Enrolled participants were randomly assigned in a 1:1 ratio according to a random code generated by the trial statistician, with a permuted block design (using a block size of 4 or 6) within each centre, to receive lumboperitoneal shunt surgery within 1 month after randomisation, or to surgery postponed for 3 months. Patients and assessors were not masked to treatment assignment. The primary endpoint was favourable outcome, defined as an improvement of one point or more on the modified Rankin scale (mRS) at 3 months after randomisation, analysed by intention to treat, and the main secondary endpoint was the same outcome 12 months after surgery, analysed per protocol. This trial is registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), number UMIN000002730. FINDINGS: Between March 1, 2010, and Oct 19, 2011, 93 patients with idiopathic normal pressure hydrocephalus were enrolled and randomly assigned to the immediate treatment group (n=49) or the postponed treatment group (n=44). More patients in the immediate treatment group than in the postponed treatment group had an improvement of one point or more on the mRS at 3 months: 32 (65%) of 49 in the immediate group vs 2 (5%) of 44 in the postponed group (difference 61% [95% CI 42-68]; p<0·0001). The number of patients who had an improvement of one point or more on the mRS at 12 months after surgery was similar between the two groups: 30 (67%) of 45 patients in the immediate group vs 22 (58%) of 38 in the postponed group (difference 9% [95% CI -14 to 31]; p=0·496). The proportions of patients with serious adverse events did not differ significantly between the groups during the 3 months post-randomisation (7 [15%] of 46 in the immediate group vs 1 [2%] of 42 in the postponed group; p=0·060). During the 12 months after surgery, 19 (22%) of 87 patients had serious adverse events, the most common of which was cerebral infarction (six patients [7%]). INTERPRETATION: Our results suggest that lumboperitoneal shunt surgery might be beneficial for patients with idiopathic normal pressure hydrocephalus and, if these findings are confirmed in larger studies, could be a first-line treatment option for this disease. FUNDING: Johnson & Johnson and Nihon Medi-Physics.
• Radiation exposure of nursing staff in PET practices in correlation to performance status of patients

  Makoto Hosono; Naomi Takahara; Yuuko Yakushiji; Kenta Sakaguchi; Kazunari Ishii

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 56 (3) 0161-5505 2015/05 [Refereed]
  
• Heterogeneity of intratumoral In-111-ibritumomab tiuxetan and F-18-FDG distribution in association with therapeutic response in radioimmunotherapy for B-cell non-Hodgkin's lymphoma

  Kohei Hanaoka; Makoto Hosono; Yoichi Tatsumi; Kazunari Ishii; Sung-Woon Im; Norio Tsuchiya; Kenta Sakaguchi; Itaru Matsumura

  EJNMMI RESEARCH SPRINGER HEIDELBERG 5 10  2191-219X 2015/03 [Refereed]
   

  Background: The purpose of this study was to quantitatively evaluate the tumor accumulation and heterogeneity of In-111-ibritumomab tiuxetan (Zevalin (R)) and tumor accumulation of F-18-fluoro-deoxyglucose (FDG) and compare them to the tumor response in B-cell non-Hodgkin's lymphoma patients receiving Y-90-ibritumomab tiuxetan (Zevalin (R)) therapy. Methods: Sixteen patients with histologically confirmed non-Hodgkin's B-cell lymphoma who underwent Y-90-ibritumomab tiuxetan therapy along with In-111-ibritumomab tiuxetan single-photon emission computerized tomography (SPECT)/CT and FDG positron emission tomography (PET)/CT were enrolled in this retrospective study. On pretherapeutic FDG PET/CT images, the maximum standardized uptake value (SUVmax) was measured. On SPECT/CT images, a percentage of the injected dose per gram (%ID/g) and SUVmax of In-111-ibritumomab tiuxetan were measured at 48 h after its administration. The skewness and kurtosis of the voxel distribution were calculated to evaluate the intratumoral heterogeneity of tumor accumulation. As another intratumoral heterogeneity index, cumulative SUV-volume histograms describing the percentage of the total tumor volume above the percentage thresholds of pretherapeutic FDG and In-111-ibritumomab tiuxetan SUVmax (area under the curve of the cumulative SUV histograms (AUC-CSH)) were calculated. All lesions (n = 42) were classified into responders and non-responders lesion-by-lesion on pre- and post-therapeutic CT images. Results: A positive correlation was observed between the FDG SUVmax and accumulation of In-111-ibritumomab tiuxetan in lesions. A significant difference in pretherapeutic FDG SUVmax was observed between responders and non-responders, while no significant difference in In-111-ibritumomab tiuxetan SUVmax was observed between the two groups. In contrast, voxel distribution of FDG demonstrated no significant differences in the three heterogeneity indices between responders and non-responders, while In-111-ibritumomab tiuxetan demonstrated skewness of 0.58 +/- 0.16 and 0.73 +/- 0.24 (p < 0.05), kurtosis of 2.39 +/- 0.32 and 2.78 +/- 0.53 (p < 0.02), and AUC-CSH of 0.37 +/- 0.04 and 0.34 +/- 0.05 (p < 0.05) for responders and non-responders. Conclusions: Pretherapeutic FDG accumulation was predictive of the tumor response in Y-90-ibritumomab tiuxetan therapy. The heterogeneity of the intratumoral distribution rather than the absolute level of In-111-ibritumomab tiuxetan was correlated with the tumor response.
• Comparison Between T1 Relaxation Time of Gd-EOB-DTPA-Enhanced MRI and Liver Stiffness Measurement of Ultrasound Elastography in the Evaluation of Cirrhotic Liver

  Masahiro Okada; Takamichi Murakami; Norihisa Yada; Kazushi Numata; Minori Onoda; Tomoko Hyodo; Tatsuo Inoue; Kazunari Ishii; Masatoshi Kudo

  JOURNAL OF MAGNETIC RESONANCE IMAGING WILEY-BLACKWELL 41 (2) 329 - 338 1053-1807 2015/02 [Refereed]
   

  PurposeTo compare four imaging approaches in cirrhotic estimation; pre-enhancement T1 relaxation time (T1RT), reduction rate (RR) of T1RT, signal-based liver-to-muscle ratio (L/M ratio) on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), and liver stiffness measurement (LSM) of US elastography. Materials and MethodsConsecutive 58 patients with chronic liver diseases who underwent both Gd-EOB-DTPA-enhanced MRI and FibroScan were analyzed. Four imaging approaches were evaluated by fibrosis score from liver biopsy and receiver operating characteristic (ROC) analysis. ResultsRR was found to be inversely correlated with LSM (r=-0.65). RR decreased with degree of fibrosis (F0-F1, 58.56.2%, versus F2-F3-F4, 48.8 +/- 11.7%, P=0.010, F0-F1-F2, 58.2 +/- 6.2% versus F3-F4, 45.5 +/- 12.3%, P=0.010 and F0-F1, 58.5 +/- 6.2%, versus F2-F3, 52.1 +/- 12.0%, P=0.0038). LSM increased with degree of fibrosis (F0-F1, 5.4 +/- 2.2 kPa versus F2-F3-F3, 19.3 +/- 15.5 kPa, P=0.0011 and F0-F1-F2, 6.8 +/- 3.6 kPa versus F3-F4, 23.8 +/- 17.1 kPa, P=0.0029 and F0-F1, 5.4 +/- 2.2 kPa, versus F2-F3, 11.4 +/- 7.2 kPa, P=0.0098). Area under ROC curves were 0.83 (F3-F4), 0.72 (F2-F3-F4), 0.68 (F2-F3) for RR and 0.83 (F3-F4), 0.88 (F2-F3-F4), 0.81 (F2-F3) for LSM in discriminating between patients with fibrosis. ConclusionThe capability by LSM was better than those by RR of T1RT, pre-enhancement T1RT, and L/M ratio to differentiate F2, but LSM and RR of T1RT showed the same value to differentiate F3. J. Magn. Reson. Imaging 2015;41:329-338.(c) 2013 Wiley Periodicals, Inc.
• Investigation of C-11-PiB equivocal PET findings

  Chisa Hosokawa; Kazunari Ishii; Tomoko Hyodo; Kenta Sakaguchi; Kimio Usami; Kenji Shimamoto; Yuzuru Yamazoe; Makoto Hosono; Kazushi Hanada; Masami Ueda; Kazuma Saigo; Takamichi Murakami

  ANNALS OF NUCLEAR MEDICINE SPRINGER 29 (2) 164 - 169 0914-7187 2015/02 [Refereed]
   

  We have encountered occasional equivocal findings when assessing cerebral cortical amyloid retention with C-11-Pittsburgh compound B (PiB) PET. We investigated the diagnostic significance of equivocal PiB PET findings. This retrospective study included 101 consecutive patients complaining of cognitive disorders (30 Alzheimer's disease, 25 mild cognitive impairment, 8 Lewy body disease, 7 frontotemporal lobar degeneration, 31 others) who underwent both C-11-PiB PET and F-18-fluorodeoxy-d-glucose (FDG) PET. We visually classified PiB-positive, PiB-equivocal or PiB-negative ratings according to cortical uptake. For quantitative assessments of PiB PET, standard uptake values referred to cerebellar cortex (SUVR) were calculated in regional template volume of interests (frontal, temporoparietal, precuneus/posterior cingulate cortex, cerebral white matter and cerebellar cortex). The results of visual assessment were compared with the regional and mean cortical SUVRs and cortical-to-white matter ratio of PiB uptake, as well as clinical and FDG PET findings. Among the 101 scans, 41 were PiB negative, 11 were PiB equivocal, and 49 were rated PiB positive in the visual assessments. The mean cortical SUVR and cortical-to-white matter ratio were 0.97 +/- A 0.07 and 0.57 +/- A 0.21 in PiB-negative, 1.51 +/- A 0.17 and 0.75 +/- A 0.06 in PiB equivocal and 2.10 +/- A 0.33 and 0.97 +/- A 0.11 in PiB-positive group, respectively. Nine of 11 subjects with PiB-equivocal findings had cognitive impairments and FDG distribution compatible with Alzheimer's disease or dementia with Lewy bodies. We considered equivocal visual findings on PiB PET equivalent to PiB-positive with slight cortical uptake. In addition, slight cortical amyloid deposits were considered to cause cerebral metabolic abnormality and cognitive impairment. Although mean cortical SUVR was more sensitive than visual assessment because of low cortical-to-white matter contrast due to non-specific accumulation in white matter, it is important not to overlook small amounts of cortical uptake of PiB in visual inspection for exact diagnosis.
• Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition

  Kazunari Ishii; Chisa Hosokawa; Tomoko Hyodo; Kenta Sakaguchi; Kimio Usami; Kenji Shimamoto; Makoto Hosono; Yuzuru Yamazoe; Takamichi Murakami

  ANNALS OF NUCLEAR MEDICINE SPRINGER 29 (1) 78 - 83 0914-7187 2015/01 [Refereed]
   

  There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition. The aim of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the DLB brain and measure the degree of regional hypometabolism. Ten consecutive subjects with DLB and 10 AD patients who underwent both Pittsburgh compound B (PiB)-PET and F-18-fluoro-2-deoxyglucose (FDG)-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG- and PiB-PET images. All AD patients and five DLB patients showed amyloid deposits (PiB positive). In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups. There were no differences in regional glucose metabolism between PiB positive and negative DLB patients. In the DLB brain, it is suggested that decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area and the degree of parietotemporal and occipital hypometabolism in DLB brain is much larger than that in AD brain.
• Prediction of Outcomes in Mild Cognitive Impairment by Using F-18-FDG-PET: A Multicenter Study

  Kengo Ito; Hidenao Fukuyama; Michio Senda; Kazunari Ishii; Kiyoshi Maeda; Yasuji Yamamoto; Yasuomi Ouchi; Kenji Ishii; Ayumu Okumura; Ken Fujiwara; Takashi Kato; Yutaka Arahata; Yukihiko Washimi; Yoshio Mitsuyama; Kenichi Meguro; Mitsuru Ikeda

  JOURNAL OF ALZHEIMERS DISEASE IOS PRESS 45 (2) 543 - 552 1387-2877 2015 [Refereed]
   

  Background: F-18-FDG-PET is defined as a biomarker of neuronal injury according to the revised National Institute on Aging-Alzheimer's Association criteria. Objective: The objective of this multicenter prospective cohort study was to examine the value of F-18-FDG-PET in predicting the development of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Methods: In total, 114 patients with MCI at 9 participating institutions underwent clinical and neuropsychological examinations, MRI, and F-18-FDG-PET at baseline. The cases were visually classified into predefined dementia patterns by three experts. An automated analysis for F-18-FDG-PET was also performed to calculate the PET score. Subjects were followed periodically for 3 years, and progression to dementia was evaluated. Results: In 47% of the patients with MCI, progression of symptoms justified the clinical diagnosis of "probable AD". The PET visual interpretation predicted conversion to AD during 3-year follow-up with an overall diagnostic accuracy of 68%. Overall diagnostic accuracy of the PET score was better than that of PET visual interpretation at all follow-up intervals, and the optimized PET score threshold revealed the best performance at the 2-year follow-up interval with an overall diagnostic accuracy of 83%, a sensitivity of 70%, and a specificity of 90%. Multivariate logistic regression analysis identified the PET score as the most significant predictive factor distinguishing AD converters from non-converters. Conclusion: The PET score is the most statistically significant predictive factor for conversion from MCI to AD, and the diagnostic performance of the PET score is more promising for rapid converters over 2 years.
• Slow Progression of Cognitive Dysfunction of Alzheimer's Disease in Sexagenarian Women with Schizophrenia.

  Sakai K; Oda H; Terashima A; Ishii K; Maeda K

  Case reports in psychiatry 2015 968598  2090-682X 2015 [Refereed]
  
• Chlamydia pneumoniae harness host NLRP3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages

  Ryota Itoh; Issaku Murakami; Bin Chou; Kazunari Ishii; Toshinori Soejima; Toshihiko Suzuki; Kenji Hiromatsu

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ACADEMIC PRESS INC ELSEVIER SCIENCE 452 (3) 689 - 694 0006-291X 2014/09 [Refereed]
   

  Chlamydia pneumoniae is an obligate intracellular pathogen that replicates within a vacuole and acquires host cell nutrients. We show that C. pneumoniae utilizes host innate immune signaling NLRP3/ASC/caspase-1 inflammasome for intracellular growth. Bone marrow-derived macrophages (BMMs) secreted mature interleukin-1 beta upon infection with C. pneumoniae depending on the NLRP3 inflammasome activation. Intracellular growth of C. pneumoniae was severely impaired in BMMs from Nlrp3(-/-), Asc(-/-) and Casp1(-/-) mice but not wild type or Nlrc4(-/-) mice. Furthermore defective NLRP3 inflammasome components led to accumulation of lipid droplets inside the infected BMMs, suggesting that uptake and/or utilization of lipids is disturbed in the absence of NLRP3 inflammasome activation. These results suggest C. pneumoniae has evolved to harness both host innate immune response and NLRP3 inflammasome activation, for the acquisition of essential nutrients necessary for intracellular growth. This unique property of C. pneumoniae may shed a new light on how C. pneumoniae increase the risk of atherosclerosis and metabolic syndrome. (C) 2014 Elsevier Inc. All rights reserved.
• Computer-assisted system for diagnosing degenerative dementia using cerebral blood flow SPECT and 3D-SSP: a multicenter study

  Kazunari Ishii; Kengo Ito; Atsushi Nakanishi; Shin Kitamura; Akira Terashima

  JAPANESE JOURNAL OF RADIOLOGY SPRINGER 32 (7) 383 - 390 1867-1071 2014/07 [Refereed]
   

  Due to increasing numbers of patients with dementia, more physicians who do not specialize in brain nuclear medicine are being asked to interpret SPECT images of cerebral blood flow. We conducted a multicenter study to determine whether a computer-assisted diagnostic system Z-score summation analysis method (ZSAM) using three-dimensional stereotactic surface projections (3D-SSP) can differentiate Alzheimer's disease (AD)/dementia with Lewy bodies (DLB) and non-AD/DLB in institutions using various types of gamma cameras. We determined the normal thresholds of Z-sum (summed Z-score) within a template region of interest for each single photon emission computed tomography (SPECT) device and then compared them with the Z-sums of patients and calculated the accuracy of the differential diagnosis by ZSAM. We compared the diagnostic accuracy between ZSAM and visual assessment. We enrolled 202 patients with AD (mean age, 76.8 years), 40 with DLB (mean age 76.3 years) and 36 with non-AD/DLB (progressive supranuclear palsy, n = 10; frontotemporal dementia, n = 20; slowly progressive aphasia, n = 2 and one each with idiopathic normal pressure hydrocephalus, corticobasal degeneration, multiple system atrophy and Parkinson's disease) who underwent N-isopropyl-p-[I-123] iodoamphetamine cerebral blood flow SPECT imaging at each participating institution. The ZSAM sensitivity to differentiate between AD/DLB and non-AD/DLB in all patients, as well as those with mini-mental state examination scores of a parts per thousand yen24 and 20-23 points were 88.0, 78.0 and 88.4 %, respectively, with specificity of 50.0, 44.4 and 60.0 %, respectively. The diagnostic accuracy rates were 83.1, 72.9 and 84.2 %, respectively. The areas under receiver operating characteristics curves for visual inspection by four expert raters were 0.74-0.84, 0.66-0.85 and 0.81-0.93, respectively, in the same patient groups. The diagnostic accuracy rates were 70.9-89.2 %, 50.9-84.8 % and 76.2-93.1 %, respectively. The diagnostic accuracy of ZSAM to differentiate AD/DLB from other types of dementia or degenerative diseases regardless of severity was equal to that of visual assessment by expert raters even across several institutions. These findings suggested that ZSAM could serve as a supplementary tool to help expert evaluators who differentially diagnose dementia from SPECT images by visual assessment.
• Heterogeneity of intratumoral In-111-Zevalin and FDG distribution in association with therapeutic response in radioimmunotherapy for B-cell lymphoma

  Hosono Makoto; Hanaoka Kohei; Ishii Kazunari; Sakaguchi Kenta; Im Sung-Woon; Tsuchiya Norio; Komeya Yoshihiro; Tatsumi Yoichi; Matsumura Itaru

  JOURNAL OF NUCLEAR MEDICINE 55 0161-5505 2014/05 [Refereed]
  
• Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images

  Hosokawa Chisa; Ishii Kazunari; Kimura Yuichi; Sakaguchi Kenta; Hosono Makoto; Murakami Takamichi

  JOURNAL OF NUCLEAR MEDICINE 55 0161-5505 2014/05 [Refereed]
  
• High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-weighted MR Images: Relationship with Increasing Cumulative Dose of a Gadolinium-based Contrast Material

  Tomonori Kanda; Kazunari Ishii; Hiroki Kawaguchi; Kazuhiro Kitajima; Daisuke Takenaka

  RADIOLOGY RADIOLOGICAL SOC NORTH AMERICA 270 (3) 834 - 841 0033-8419 2014/03 [Refereed]
   

  Purpose: To explore any correlation between the number of previous gadolinium-based contrast material administrations and high signal intensity (SI) in the dentate nucleus and globus pallidus on unenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods: The institutional review board approved this study, waiving the requirement to obtain written informed consent. A group of 381 consecutive patients who had undergone brain MR imaging was identified for cross-sectional analysis. For longitudinal analysis, 19 patients who had undergone at least six contrast-enhanced examinations were compared with 16 patients who had undergone at least six unenhanced examinations. The mean SIs of the dentate nucleus, pons, globus pallidus, and thalamus were measured on unenhanced T1-weighted images. The dentate nucleus-to-pons SI ratio was calculated by dividing the SI in the dentate nucleus by that in the pons, and the globus pallidus-to-thalamus SI ratio was calculated by dividing the SI in the globus pallidus by that in the thalamus. Stepwise regression analysis was undertaken in the consecutive patient group to detect any relationship between the dentate nucleus-to-pons or globus pallidus-to-thalamus SI ratio and previous gadolinium- based contrast material administration or other factors. A random coefficient model was used to evaluate for longitudinal analysis. Results: The dentate nucleus-to-pons SI ratio showed a significant correlation with the number of previous gadolinium-based contrast material administrations (P <.001; regression coefficient, 0.010; 95% confidence interval [CI]: 0.009, 0.011; standardized regression coefficient, 0.695). The globus pallidus-to-thalamus SI ratio showed a significant correlation with the number of previous gadolinium-based contrast material administrations (P <.001; regression coefficient, 0.004; 95% CI: 0.002, 0.006; standardized regression coefficient, 0.288), radiation therapy (P=.009; regression coefficient, -0.014; 95% CI: -0.025, -0.004; standardized regression coefficient, -0.151), and liver function (P=.031; regression coefficient, 0.023; 95% CI: 0.002, 0.044; standardized regression coefficient, 0.107). The dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios in patients who had undergone contrast-enhanced examinations were significantly greater than those of patients who had undergone unenhanced examinations(P <.001 for both). Conclusion: High SI in the dentate nucleus and globus pallidus on unenhanced T1-weighted images may be a consequence of the number of previous gadolinium- based contrast material administrations. (C) RSNA, 2013
• Visual-statistical interpretation of 18F-FDG-PET images for characteristic alzheimer patterns in a multicenter study: Inter-rater concordance and relationship to automated quantitative evaluation

  Tomohiko Yamane; Y. Ikari; T. Nishio; Kazunari Ishii; Kenji Ishii; T. Kato; Kengo Ito; D. H.S. Silverman; M. Senda; T. Asada; H. Arai; M. Sugishita; T. Iwatsubo

  American Journal of Neuroradiology 35 (2) 244 - 249 0195-6108 2014/02 [Refereed]
   

  BACKGROUND AND PURPOSE: The role of 18F-FDG-PET in the diagnosis of Alzheimer disease is increasing and should be validated. The aim of this study was to assess the inter-rater variability in the interpretation of 18F-FDG-PET images obtained in the Japanese Alzheimer's Disease Neuroimaging Initiative, a multicenter clinical research project. MATERIALS AND METHODS: This study analyzed 274 18F-FDG-PET scans (67 mild Alzheimer disease, 100 mild cognitive impairment, and 107 normal cognitive) as baseline scans for the Japanese Alzheimer's Disease Neuroimaging Initiative, which were acquired with various types of PET or PET/CT scanners in 23 facilities. Three independent raters interpreted all PET images by using a combined visual-statistical method. The images were classified into 7 (FDG-7) patterns by the criteria of Silverman et al and further into 2 (FDG-2) patterns. RESULTS: Agreement among the 7 visual-statistical categories by at least 2 of the 3 readers occurred in > 94% of cases for all groups: Alzheimer disease, mild cognitive impairment, and normal cognitive. Perfect matches by all 3 raters were observed for 62% of the cases by FDG-7 and 76 by FDG-2. Inter-rater concordance was moderate by FDG-7 (κ = 0.57) and substantial in FDG-2 (κ = 0.67) on average. The FDG-PET score, an automated quantitative index developed by Herholz et al, increased as the number of raters who voted for the AD pattern increased (ρ = 0.59, P < .0001), and the FDG-PET score decreased as those for normal pattern increased (ρ =-0.64, P < .0001). CONCLUSIONS: Inter-rater agreement was moderate to substantial for the combined visual-statistical interpretation of 18F-FDG-PET and was also significantly associated with automated quantitative assessment.
• A comparison of three brain atlases for MCI prediction.

  Kenichi Ota; Naoya Oishi; Kengo Ito; Hidenao Fukuyama

  Journal of neuroscience methods 221 139 - 50 2014/01 

  BACKGROUND: Although previous voxel-based studies using features extracted by atlas-based parcellation produced relatively poor performances on the prediction of Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI), classification performance usually depends on features extracted from the original images by atlas-based parcellation. To establish whether classification performance differs depending on the choice of atlases, support vector machine (SVM)-based classification using different brain atlases was performed. NEW METHOD: Seventy-seven three-dimensional T1-weighted MRI data sets of subjects with amnestic MCI, including 39 subjects who developed AD (MCI-C) within three years and 38 who did not (MCI-NC), were used for voxel-based morphometry (VBM) analyses and analyzed using SVM-based pattern recognition methods combined with a feature selection method based on the SVM recursive feature elimination (RFE) method. Three brain atlases were used for the feature selections: the Automated Anatomical Labeling (AAL) Atlas, Brodmann's Areas (BA), and the LONI Probabilistic Brain Atlas (LPBA40). RESULTS: The VBM analysis showed a significant cluster of gray matter density reduction, located at the left hippocampal region, in MCI-C compared to MCI-NC. The SVM analyses with the SVM-RFE algorithm revealed that the best classification performance was achieved by LPBA40 with 37 selected features, giving an accuracy of 77.9%. The overall performance in LPBA40 was better than that of AAL and BA regardless of the number of selected features. CONCLUSIONS: These results suggest that feature selection is crucial to improve the classification performance in atlas-based analysis and that the choice of atlases is also important.
• Clinical application of 18F-fluorodeoxyglucose positron emission tomography for assessment and evaluation after therapy for malignant hepatic tumor

  Masakatsu Tsurusaki; Masahiko Okada; Hiroyuki Kuroda; Mitsuru Matsuki; Kazunari Ishii; Takamichi Murakami

  JOURNAL OF GASTROENTEROLOGY SPRINGER JAPAN KK 49 (1) 46 - 56 0944-1174 2014/01 [Refereed]
   

  Positron emission tomography (PET) is widely available and its application with 2-[F-18] fluoro-2-deoxy-D-glucose (F-18-FDG) in oncology has become one of the standard imaging modalities in diagnosing and staging of tumors, and monitoring the therapeutic efficacy in hepatic malignancies. Recently, investigators have measured glucose utilization in liver tumors using F-18-FDG and positron emission tomography/computer tomography (PET/CT) in order to establish a diagnosis of tumors, assess their biologic characteristics and predict therapeutic effects on hepatic malignancies. The PET/CT with F-18-FDG may further enhance the hepatic malignancy diagnostic algorithm by accurate diagnosis, staging, restaging and evaluating its biological characteristics, which can benefit the patients suffering from primary and metastatic hepatic tumors such as hepatocellular carcinoma (HCC), cholangiocarcinoma (CCC), and metastatic liver tumor.
• Multiple thalamo-cortical disconnections in anterior thalamic infarction: Implications for thalamic mechanisms of memory and language

  Yoshiyuki Nishio; Mamoru Hashimoto; Kazunari Ishii; Daisuke Ito; Shunji Mugikura; Shoki Takahashi; Etsuro Mori

  NEUROPSYCHOLOGIA PERGAMON-ELSEVIER SCIENCE LTD 53 (1) 264 - 273 0028-3932 2014/01 [Refereed]
   

  Amnesia and linguistic deficits that are associated with thalamic damage have attracted the attention of researchers interested in identifying the neural networks involved in memory and language. The Papez circuit, which is composed of the hippocampus, mammillary body and anterior thalamic nuclei, was first proposed to be critical for memory. However, subsequently, the roles of the neural circuit consisting of the rhinal/parahippocampal cortices and the mediodorsal thalamic nuclei became evident. The ventral lateral nuclei or its adjacent structures have been found to be involved in semantic processing, but the specific neural circuits dedicated to language functions have not been identified. Anterior thalamic infarcts, which affect very circumscribed regions of the ventral anterior portion of the thalamus, often cause paradoxically prominent memory and language deficits. We conducted tractography analyses in 6 patients with left anterior thalamic infarcts to identify neural connections or circuits in which disruptions are associated with memory and language deficits in this condition. The current study demonstrated that the mammillothalamic tract, which connects the mammillary body with the anterior thalamic nuclei, and the anterior and inferior thalamic peduncles, which contain neural fibers that extend from several thalamic nuclei to the anterior temporal, medial temporal and frontal cortices, are disrupted in anterior thalamic infarction. These extensive thalamo-cortical disconnections appear to be due to the dissection of the neural fibers that penetrate the ventral anterior nucleus of the thalamus. Our results suggest the following: (1) amnesia that is associated with anterior thalamic infarction is best interpreted in the context of dual/multiple-system theories of memory/amnesia that posit that multiple neural circuits connecting the anterior and mediodorsal thalamic nuclei with the hippocampus and rhinal/parahippocampal cortices work in concert to support memory function; and (2) the semantic deficits observed in this syndrome may be associated with thalamo-anterior temporal and thalamo-lateral frontal disconnections. (C) 2013 Elsevier Ltd. All rights reserved.
• Clinical application of 3D arterial spin-labeled brain perfusion imaging for alzheimer disease: Comparison with brain perfusion SPECT

  H. Takahashi; K. Ishii; C. Hosokawa; T. Hyodo; N. Kashiwagi; M. Matsuki; R. Ashikaga; T. Murakami

  American Journal of Neuroradiology American Society of Neuroradiology 39 (5) 906 - 911 1936-959X 2014 [Refereed]
   

  BACKGROUND AND PURPOSE: Alzheimer disease is the most common neurodegenerative disorder with dementia, and a practical and economic biomarker for diagnosis of Alzheimer disease is needed. Three-dimensional arterial spin-labeling, with its high signal-to-noise ratio, enables measurement of cerebral blood flow precisely without any extrinsic tracers. We evaluated the performance of 3D arterial spin-labeling compared with SPECT, and demonstrated the 3D arterial spin-labeled imaging characteristics in the diagnosis of Alzheimer disease. MATERIALS AND METHODS: This study included 68 patients with clinically suspected Alzheimer disease who underwent both 3D arterial spin-labeling and SPECT imaging. Two readers independently assessed both images. Kendall W coefficients of concordance (K) were computed, and receiver operating characteristic analyses were performed for each reader. The differences between the images in regional perfusion distribution were evaluated by means of statistical parametric mapping, and the incidence of hypoperfusion of the cerebral watershed area, referred to as "borderzone sign" in the 3D arterial spin-labeled images, was determined. RESULTS: Readers showed K = 0.82/0.73 for SPECT/3D arterial spin-labeled imaging, and the respective areas under the receiver operating characteristic curve were 0.82/0.69 for reader 1 and 0.80/0.69 for reader 2. Statistical parametric mapping showed that the perisylvian and medial parieto-occipital perfusion in the arterial spin-labeled images was significantly higher than that in the SPECT images. Borderzone sign was observed on 3D arterial spin-labeling in 70% of patients misdiagnosed with Alzheimer disease. CONCLUSIONS: The diagnostic performance of 3D arterial spin-labeling and SPECT for Alzheimer disease was almost equivalent. Three-dimensional arterial spin-labeled imaging was more influenced by hemodynamic factors than was SPECT imaging.
• Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models.

  Yoshito Fujii; Satoshi Kaneko; Samson Muuo Nzou; Matilu Mwau; Sammy M Njenga; Chihiro Tanigawa; James Kimotho; Anne Wanjiru Mwangi; Ibrahim Kiche; Sohkichi Matsumoto; Mamiko Niki; Mayuko Osada-Oka; Yoshio Ichinose; Manabu Inoue; Makoto Itoh; Hiroshi Tachibana; Kazunari Ishii; Takafumi Tsuboi; Lay Myint Yoshida; Dinesh Mondal; Rashidul Haque; Shinjiro Hamano; Mwatasa Changoma; Tomonori Hoshi; Ken-Ichi Kamo; Mohamed Karama; Masashi Miura; Kenji Hirayama

  PLoS neglected tropical diseases 8 (7) e3040  1935-2727 2014 [Refereed]
   

  BACKGROUND: A strategy to combat infectious diseases, including neglected tropical diseases (NTDs), will depend on the development of reliable epidemiological surveillance methods. To establish a simple and practical seroprevalence detection system, we developed a microsphere-based multiplex immunoassay system and evaluated utility using samples obtained in Kenya. METHODS: We developed a microsphere-based immuno-assay system to simultaneously measure the individual levels of plasma antibody (IgG) against 8 antigens derived from 6 pathogens: Entamoeba histolytica (C-IgL), Leishmania donovani (KRP42), Toxoplasma gondii (SAG1), Wuchereria bancrofti (SXP1), HIV (gag, gp120 and gp41), and Vibrio cholerae (cholera toxin). The assay system was validated using appropriate control samples. The assay system was applied for 3411 blood samples collected from the general population randomly selected from two health and demographic surveillance system (HDSS) cohorts in the coastal and western regions of Kenya. The immunoassay values distribution for each antigen was mathematically defined by a finite mixture model, and cut-off values were optimized. FINDINGS: Sensitivities and specificities for each antigen ranged between 71 and 100%. Seroprevalences for each pathogen from the Kwale and Mbita HDSS sites (respectively) were as follows: HIV, 3.0% and 20.1%; L. donovani, 12.6% and 17.3%; E. histolytica, 12.8% and 16.6%; and T. gondii, 30.9% and 28.2%. Seroprevalences of W. bancrofti and V. cholerae showed relatively high figures, especially among children. The results might be affected by immunological cross reactions between W. bancrofti-SXP1 and other parasitic infections; and cholera toxin and the enterotoxigenic E. coli (ETEC), respectively. INTERPRETATION: A microsphere-based multi-serological assay system can provide an opportunity to comprehensively grasp epidemiological features for NTDs. By adding pathogens and antigens of interest, optimized made-to-order high-quality programs can be established to utilize limited resources to effectively control NTDs in Africa.
• Can Low-dose CT with Iterative Reconstruction Reduce Both the Radiation Dose and the Amount of Iodine Contrast Medium in a Dynamic CT Study of the Liver?

  Takahashi H; Okada M; Kagawa Y; Hyodo T; Hidaka S; Kudo M; Ishii K; Tomiyama N; Murakami T

  Eur J Radiol. Elsevier 83 684 - 691 2013/12 [Refereed]
  
• Prediction of outcomes in MCI with I-123-IMP-CBF SPECT: a multicenter prospective cohort study

  Kengo Ito; Etsuro Mori; Hidenao Fukuyama; Kazunari Ishii; Yukihiko Washimi; Takashi Asada; Satoru Mori; Kenichi Meguro; Shin Kitamura; Haruo Hanyu; Seigo Nakano; Hiroshi Matsuda; Yasuo Kuwabara; Kazuo Hashikawa; Toshimitsu Momose; Yoshitaka Uchida; Jun Hatazawa; Satoshi Minoshima; Kenji Kosaka; Tatsuo Yamada; Yoshiharu Yonekura

  ANNALS OF NUCLEAR MEDICINE SPRINGER 27 (10) 898 - 906 0914-7187 2013/12 [Refereed]
   

  The multicenter prospective cohort study (Japan Cooperative SPECT Study on Assessment of Mild Impairment of Cognitive Function: J-COSMIC) aimed to examine the value of I-123-N-isopropyl-4-iodoamphetamine cerebral blood flow (IMP-CBF) SPECT in regards to early diagnosis of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Three hundred and nineteen patients with amnestic MCI at 41 participating institutions each underwent clinical and neuropsychological examinations and I-123-IMP-CBF SPECT at baseline. Subjects were followed up periodically for 3 years, and progression to dementia was evaluated. SPECT images were classified as AD/DLB (dementia with Lewy bodies) pattern and non-AD/DLB pattern by central image interpretation and automated region of interest (ROI) analysis, respectively. Logistic regression analyses were used to assess whether baseline I-123-IMP-CBF SPECT was predictive of longitudinal clinical outcome. Ninety-nine of 216 amnestic MCI patients (excluding 3 cases with epilepsy (n = 2) or hydrocephalus (n = 1) and 100 cases with incomplete follow-up) converted to AD within the observation period. Central image interpretation and automated ROI analysis predicted conversion to AD with 56 and 58 % overall diagnostic accuracy (sensitivity, 76 and 81 %; specificity, 39 and 37 %), respectively. Multivariate logistic regression analysis identified SPECT as a predictor, which distinguished AD converters from non-converters. The odds ratio for a positive SPECT to predict conversion to AD with automated ROI analysis was 2.5 and combining SPECT data with gender and mini-mental state examination (MMSE) further improved classification (joint odds ratio 20.08). I-123-IMP-CBF SPECT with both automated ROI analysis and central image interpretation was sensitive but relatively nonspecific for prediction of clinical outcome during the 3-year follow-up in individual amnestic MCI patients. A combination of statistically significant predictors, both SPECT with automated ROI analysis and neuropsychological evaluation, may increase predictive utility.
• Intravertebral pneumatocysts of the cervical spine

  Yuko Matsukubo; Nobuo Kashiwagi; Masanobu Uemura; Sachiyo Tatsumi; Hiroto Takahashi; Tomoko Hyodo; Noriyuki Tomiyama; Ryuichiro Ashikaga; Kazunari Ishii; Takamichi Murakami

  Neuroradiology 11 55 (11) 1341 - 1344 0028-3940 2013/11 [Refereed]
   

  Introduction: The aim of this study was to investigate the prevalence of intravertebral pneumatocyst (IVP) of the cervical spine by age group, compared with that of intradiscal vacuum (IDV). Methods: We investigated 500 consecutive patients who underwent cervical computed tomography (CT) from May 2012 to May2013 for various indications. CT datasets were assessed for the presence of IVPs and IDVs with stratification by age. Results: IVPs of the cervical spine were detected in 8 % (7 of 86 subjects) of patients in their forties or below, 30 % (23 of 75) in their fifties, 49 % (67 of 136) in their sixties, 55 % (76 of 137) in their seventies, and 60 % (40 of 66) in their eighties or over. IDVs of the cervical spine were detected in 6, 25, 48, 54, and 57 %, respectively. Coexistence of both phenomena was identified in 4, 17, 33, 40, and 43 %, respectively. Conclusion: IVPs of the cervical spine are a common incidental finding, increasing in prevalence with age and more common than IDV in all age groups. © 2013 Springer-Verlag Berlin Heidelberg.
• Myocardial scintigraphy may predict the conversion to probable dementia with Lewy bodies

  Haruhiko Oda; Kazunari Ishii; Akira Terashima; Ken-ichi Shimada; Yumiko Yamane; Ryota Kawasaki; Shingo Ohkawa

  NEUROLOGY LIPPINCOTT WILLIAMS & WILKINS 81 (20) 1741 - 1745 0028-3878 2013/11 [Refereed]
   

  Objective: To compare the usefulness of brain perfusion SPECT and I-123-metaiodobenzylguanidine (I-123-MIBG) in predicting the conversion of possible dementia with Lewy bodies (DLB) to probable DLB. Methods: We examined 94 patients with possible DLB based on the Consensus Criteria for the Clinical Diagnosis of DLB by N-Isopropyl-p-I-123-iodoamphetamine (I-123-IMP) brain perfusion SPECT and I-123-MIBG myocardial scintigraphy. After 1 year of follow-up, 33 of 94 patients met the criteria for probable DLB. I-123-IMP brain perfusion SPECT and I-123-MIBG myocardial scintigraphy were tested as predictors of the conversion from possible DLB to probable DLB. A receiver operating characteristic (ROC) analysis was performed. Results: The areas under the ROC curves for SPECT for predicting the conversion to probable DLB from possible DLB based on the occipital/cerebellum and occipital/striatum cortex ratios of blood flow counts were 0.591 and 0.585, respectively. The areas under the ROC curves for I-123-MIBG based on the early heart to mediastinum (H/M) ratio, delayed H/M ratio, and washout rate were 0.935, 0.936, and 0.884, respectively. Conclusion: I-123-MIBG myocardial scintigraphy is a good predictor of the future conversion of possible DLB to probable DLB.
• Brain areas associated with sentence processing: A functional MRI study and a lesion study

  Rieko Okada; Takeshi Okuda; Naoki Nakano; Kazuhiko Nishimatsu; Hiroyuki Fukushima; Minori Onoda; Toshiho Otsuki; Kazunari Ishii; Takamichi Murakami; Amami Kato

  JOURNAL OF NEUROLINGUISTICS PERGAMON-ELSEVIER SCIENCE LTD 26 (4) 470 - 478 0911-6044 2013/07 [Refereed]
   

  The aim of this study was to identify the location associated with primitive sentence processing. Processing related to generation and comprehension of sentences ("sentence processing") is postulated to be largely divided into syntactic processing (processing related to the formation of sentences and to verb reflection and particles) and verb information (argument structure and thematic role). Numerous lesion studies and functional brain imaging studies on unimpaired individuals have suggested that the left inferior frontal gyrus (IFG) is involved in syntactic processing. In addition, some studies have reported that the area from the left parietal lobe to the posterior superior temporal gyrus is involved in processing information such as argument structure and thematic role. However, studies on sentence processing using functional brain imaging have used complex sentences as tasks, raising the possibility that the results show the demands on not only language processing, but also on working memory. To clarify the brain areas involved in basic sentence processing in human language, there is a need to examine tasks involved in sentence processing that assume more primitive processing with minimal demands on working memory. The present study used sentence-completion tasks in the Japanese language that include basic sentence processing. The results showed activation in the left IFG and left parietal lobe, suggesting that these areas are involved in sentence processing. We then investigated the proportion of patients showing impaired sentence processing from among patients with aphasia and a lesion in the left IFG or from the parietal lobe to the posterior superior temporal gyrus. Four of 5 patients (80%) with lesions mostly in the left IFG showed impaired sentence processing, suggesting that this site plays a critical role in sentence processing. Of the 4 patients with lesions mostly in the area from the left parietal lobe to the posterior superior temporal gyrus, 1 patient (25%) showed impaired sentence processing. Unlike the other 3 subjects, this subject exhibited impaired recalling of verbs. This area is mainly involved in lexical-semantics and the present results suggest that verb information within that field became impaired, in turn causing impaired sentence processing. (C) 2013 Elsevier Ltd. All rights reserved.
• Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study

  Ryuichi Takahashi; Kazunari Ishii; Michio Senda; Kengo Ito; Kenji Ishii; Takashi Kato; Yoko Makishi; Tomoyuki Nishio; Yasuhiko Ikari; Takeshi Iwatsubo

  ANNALS OF NUCLEAR MEDICINE SPRINGER 27 (5) 452 - 459 0914-7187 2013/06 [Refereed]
   

  To determine the optimal accumulation time for three-dimensional positron emission tomography (3D-PET) with F-18-2-fluoro-2-deoxy-d-glucose (F-18-FDG) to detect the brain uptake pattern typical of Alzheimer's disease (AD). Patients with mild AD or amnestic mild cognitive impairment (MCI) and normal control subjects were recruited in the Japanese Alzheimer's disease neuroimaging initiative and examined with a PET scan during the 30-60 min after FDG injection. Three independent blinded experts interpreted the 30- to 60-min sum images, and images of patients with AD and MCI presenting AD patterns and normal subjects presenting normal patterns were used in the analysis. Early-scan (ES) and late-scan (LS) images were obtained from the data acquired at 30-35 min and 55-60 min after the injection, respectively. Separate target regions of interest (ROI) for ES and LS were defined as areas of significant reductions in the posterior cingulate and parietotemporal lobe in both hemispheres from the results of an initial cohort with 21 patients (AD 16, MCI 5) and 19 controls. A subsequent sample of 36 (AD 9, MCI 27) patients and 38 controls were used to compare the diagnostic capability of ES and LS using Z scores within the target ROI in individual statistical parametric mapping analysis. Compared to LS, ES showed lower activity in the frontal lobes and higher activity in the venous sinus than LS; however, the diagnostic capability of ES and LS did not significantly differ (sensitivity 0.97 and 0.97, specificity 0.82 and 0.84, area under the receiver-operating characteristic curve 0.96 and 0.97, respectively). For a qualitative diagnosis of the AD pattern in 3D FDG-PET, results of ES were equivalent to those of LS. ES may be an option to shorten the entire PET procedure time, particularly in diagnosing early stages of AD.
• Erratum: Estimation of liver function using T2* mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging (European Journal of Radiology (2012) 81:7 (1460-1464))

  Takashi Katsube; Masahiro Okada; Seishi Kumano; Izumi Imaoka; Yuki Kagawa; Masatoshi Hori; Kazunari Ishii; Noboru Tanigawa; Yasuharu Imai; Masatoshi Kudo; Takamichi Murakami

  European Journal of Radiology 82 (6) 1039  0720-048X 2013/06 [Refereed]
  
• Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells

  Emi Sato; Shinichi Imafuku; Kazunari Ishii; Ryota Itoh; Bin Chou; Toshinori Soejima; Juichiro Nakayama; Kenji Hiromatsu

  JOURNAL OF DERMATOLOGICAL SCIENCE ELSEVIER IRELAND LTD 70 (3) 166 - 172 0923-1811 2013/06 [Refereed]
   

  Background: 1 alpha,25-Dihydroxyvitamin D3 (1,25(OH)2D3) up-regulates the production of human cathelicidin antimicrobial peptide (CAMP) from monocytes/macrophages infected with Mycobacterium tuberculosis (M. tbc). CAMP facilitates the co-localization of autophagolysosomes with M. tbc, promoting the antimicrobial activity of monocytes. Mycobacterium marinum (M. marinum) is an acid-fast bacillus that causes less severe granulomatous skin lesions compared with M. tbc. Objective: We investigated whether autophagic antimicrobial activity is promoted by 1,25(OH)2D3 or C-terminal of cathelicidin LL-37 in human monocytes upon infection with M. marinum. Methods: Human monocytes (THP-1) were infected with M. marinum. Effects of simultaneous treatments of 1,25(OH)2D3, exogenous LL-37 peptide, autophagolysosome inhibitors, 3-methyladenine or chloroquine, were examined. Results: CAMP was strongly induced by adding 1,25(OH)2D3 to the culture of THP-1 cells. In the absence of 1,25(OH)2D3 M. marinum infection alone did not induce CAMP, however, simultaneous addition of 1,25(OH)2D3 to M. marinum infection accelerated CAMP production more than 1,25(OH)2D3 alone. Proliferation of M. marinum was markedly decreased in the presence of 1,25(OH)2D3 or exogenous LL-37 in THP-1 cells. Co-localization of CAMP with autophagolysosome was evident in 1,25(OH)2D3 and LL-37 treated THP-1 cells after M. marinum infection. Autophagolysosome inhibitors abrogated the antimicrobial effects of 1,25(OH)2D3 and exogenous LL-37 against M. marinum infection in THP-1 cells. Conclusions: Human monocytic cells, whose CAMP production is up-regulated by 1,25(OH)2D3-vitamin D receptor pathway, accelerate antimicrobial function of autophagolysosome in M. marinum infection. (c) 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
• Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery

  Hiroaki Kazui; Etsuro Mori; Shingo Ohkawa; Takaharu Okada; Takeo Kondo; Ryuji Sakakibara; Osamu Ueki; Yoshiyuki Nishio; Kazunari Ishii; Tetsuro Kawaguchi; Masatsune Ishikawa; Masatoshi Takeda

  JOURNAL OF THE NEUROLOGICAL SCIENCES ELSEVIER 328 (1-2) 64 - 69 0022-510X 2013/05 [Refereed]
   

  We identified factors that predict the disappearance of the triad of symptoms (gait disturbance, cognitive impairment and urinary incontinence) of idiopathic normal pressure hydrocephalus (iNPH) following shunt surgery in this study. We classified 71 patients with iNPH into those whose objective symptoms disappeared (disappearance group) or remained (residual group), for each of the triad symptoms 12 months after shunt surgery. Logistic regression analyses were used to identify the predictors of the disappearance of symptoms among 10 variables before shunt surgery (e.g., age, sex, severity of symptoms, Evans index, cerebrospinal fluid (CSF) pressure, CSF stasis on computerized tomographic cisternography, regional cerebral blood flow on single photon emission computed tomography, three kinds of prior diseases). For each of the triad symptoms, mild symptoms before shunt surgery were predictors of the disappearance of the symptom. Young age was also a predictor of the disappearance of gait disturbance. When the analysis was conducted using subscores of the Mini Mental State Examination, a successful visuoconstruction subtest and an absence of hypertension were predictors of the disappearance of cognitive impairment. None of the neuroimaging examinations predicted the disappearance of symptoms after shunt surgery in this study. (c) 2013 Elsevier B.V. All rights reserved.
• Dynamic sequence respiratory gated perfusion pulmonary SPECT without external tracking device

  Kenta Sakaguchi; Makoto Hosono; Masakazu Otsuka; Kohei Hanaoka; Kimio Usami; Tatsuro Uto; Kazunari Ishii

  ANNALS OF NUCLEAR MEDICINE SPRINGER 27 (1) 65 - 73 0914-7187 2013/01 [Refereed]
   

  The purpose of this study was to develop and evaluate a new method for respiratory gated pulmonary perfusion SPECT (RGPS) based on dynamic acquisition without using an external tracking device (ETD) or list-mode data acquisition. In the phantom study, our method used a dynamic sequence technique, which was specified by sequences of 50-ms acquisition during 30 s per view of SPECT instead of using an ETD. For this purpose, we created a computer program that identified respiratory phases by calculating the center of activity (COA) in each dynamic frame image. We compared RGPS using the dynamic sequence acquisition (RGPS-DS) and RGPS using ETD (RGPS-ETD) in phantom studies employing a cylinder phantom filled with technetium-99m solution attached to an instrument providing a simple harmonic motion. In the patient study, RGPS-DS was applied to data collected from 3 patients during a routine study of Tc-MAA pulmonary perfusion SPECT. In the phantom study, the calculation of COA indicated a good agreement between RGPS-DS and RGPS-ETD. With an oscillatory phantom movement amplitude of 30 mm, the amplitudes determined by RGPS-DS and RGPS-ETD (28.36 and 27.58 mm, respectively) were identical on considering a pixel size of 4.66 mm for reconstructed SPECT images. In the patient study, applicability of our method to patient data was demonstrated. We have showed the feasibility of our method to obtain RGPS without ETD, and conclude that RGPS-DS may be an innovative and efficient technique in respiratory gated pulmonary perfusion SPECT. Further studies with a larger number of patients should demonstrate the accuracy of our method.
• Automatic volumetry of the cerebrospinal fluid space in idiopathic normal pressure hydrocephalus.

  Ishii K; Soma T; Shimada K; Oda H; Terashima A; Kawasaki R

  Dementia and geriatric cognitive disorders extra 1 3 (1) 489 - 496 2013/01 [Refereed]
  
• 【びまん性肝疾患の画像診断:Update 2012】Gd-EOB-DTPA造影MRIにおけるLook-Lockerシーケンスを用いたMR relaxometry

  小野田 農; 岡田 真広; 兵藤 朋子; 松木 充; 石井 一成; 宇都 辰郎; 村上 卓道

  臨床画像 (株)メジカルビュー社 28 (12) 1444 - 1451 0911-1069 2012/12
• The Usefullness of Conventional MR imaging in Establishing the Daiagnosis of Submandibular Pleomorphic Adenoma.

  柏木 伸夫; 高橋 洋人; 前西 修; 岡嶋 馨; 村上 卓道; 石井 一成; 中西 克之

  2012/11
• T-staging of gastric cancer of air-filling multidetector-row CT: Comparison with hydro-multidetector-row CT

  Seishi Kumano; Masahiro Okada; Taro Shimono; Masatomo Kuwabara; Yukinobu Yagyu; Izumi Imaoka; Ryuichiro Ashikaga; Kazunari Ishii; Takamichi Murakami

  EUROPEAN JOURNAL OF RADIOLOGY ELSEVIER IRELAND LTD 81 (11) 2953 - 2960 0720-048X 2012/11 [Refereed]
   

  Purpose: The purpose of this study was to evaluate the accuracy of T-staging of gastric cancer by air-filling multidetector-row CT (air-MDCT) compared with water-filling MDCT (hydro-MDCT). Materials and methods: One hundred fifteen patients with histologically diagnosed gastric cancer were included in this study. Fifty-eight patients underwent air-MDCT, and the remaining 57 had hydro-MDCT using a 64-channel scanner. Based on the volumetric data of contrast-enhanced MDCT obtained about 75 s after intravenously injecting 525 mg iodine per kilogram patients weight (525 mgI/kg) nonionic contrast material at the rate of 2 ml/s, oblique coronal and oblique sagittal multi-planar reformatted images perpendicular to the stomach wall, including the tumor, were reconstructed on a workstation. Mural invasion of gastric cancer into the gastric wall, as visualized by CT, was classified according to the TNM classification, and the results of T-staging by MDCT were compared with those by pathologic analysis after surgery. Results: Correct assessment of T-staging by air-CT was achieved in 48 of 58 patients (83%), and that by hydro-MDCT was 49 of 57 patients (86%). The sensitivity, specificity, and accuracy of the technique in determining the invasion of serosa were 88%, 93%, and 91% for air-CT and 83%, 95%, and 91% for hydro-CT. There were no significant differences between hydro-MDCT and air-MDCT in sensitivity (P = 0.73), specificity (P = 0.71) and accuracy (P = 0.98). Conclusion: Air-MDCT is a very valuable tool in T-staging of gastric cancer as well as hydro-MDCT. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
• Optimal dose of contrast medium for depiction of hypervascular HCC on dynamic MDCT

  Tetsuya Fujigai; Seishi Kumano; Masahiro Okada; Tomoko Hyodo; Izumi Imaoka; Yukinobu Yagyu; Ryuichiro Ashikaga; Kazunari Ishii; Takamichi Murakami

  EUROPEAN JOURNAL OF RADIOLOGY ELSEVIER IRELAND LTD 81 (11) 2978 - 2983 0720-048X 2012/11 [Refereed]
   

  Purpose: The purpose of this study is to prospectively investigate the optimal dose of contrast medium for the depiction of hypervascular hepatocellular carcinoma (HCC) during the hepatic arterial phase (HAP), portal venous phase (PVP) and delayed phase (DP) of dynamic MDCT. Materials and methods: The study included 128 patients, out of these patients, 36 patients were found to have 56 hypervascular HCCs. Sixty-three patients were assigned to receive a dose of 525 mgI/kg with protocol A, and 62 received a dose of 630 mgI/kg with protocol B. Measurements of the attenuation values of the abdominal aorta, portal vein, hepatic vein, hepatic parenchyma and HCC during the HAP, PVP and DP were taken. Tumor-liver contrast (TLC) was calculated from the attenuation value of the hepatic parenchyma and HCC. Results: The aortic attenuation value with protocol B (351, 166, and 132 HU) was significantly higher than that with protocol A (313, 153, and 120 HU) during all the phases, (P < 0.01 for all phases). The hepatic enhancement from unenhanced baseline with protocol B (25.2, 63.6, 50.6 HU) was significantly higher than that with protocol A (20.2, 55.1 and 43.0 HU) during all the phases, (P < 0.01 for all phases). The TLC with protocol B (37.4, -11.8 and -13.6 HU) was significantly higher than that with protocol A (28.0, -9.8 and -12.1 HU) during HAP (P = 0.042). Conclusion: The administration of 630 mgI/kg of body weight depicts hypervascular HCC more clearly during HAP and shows sufficient hepatic enhancement of 50 HU during DP. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
• Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus: Second Edition

  Etsuro Mori; Masatsune Ishikawa; Takeo Kato; Hiroaki Kazui; Hiroji Miyake; Masakazu Miyajima; Madoka Nakajima; Masaaki Hashimoto; Nagato Kuriyama; Takahiko Tokuda; Kazunari Ishii; Mitsunobu Kaijima; Yoshihumi Hirata; Makoto Saito; Hajime Arai

  NEUROLOGIA MEDICO-CHIRURGICA JAPAN NEUROSURGICAL SOC 52 (11) 775 - 809 0470-8105 2012/11 [Refereed]
   

  Among the various disorders manifesting dementia, gait disturbance, and urinary incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. After the publication of the first edition of the Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus in 2004 (the English version was published in 2008), clinical awareness of iNPH has risen dramatically, and the number of shunt surgeries has increased rapidly across Japan. Clinical and basic research on iNPH has increased significantly, and more high-level evidence has since been generated. The second edition of the Japanese Guidelines was thus published in July 2011, to provide a series of timely evidence-based recommendations related to iNPH. The revision of the Guidelines has been undertaken by a multidisciplinary expert working group of the Japanese Society of Normal Pressure Hydrocephalus in conjunction with the Japanese Ministry of Health, Labour and Welfare research project on "Studies on the epidemiology, pathophysiology, and treatment of normal pressure hydrocephalus." This English version of the second edition of the Guidelines was made to share these ideas with the international community and to promote international research on iNPH.
• レビー小体型認知症の頭頂側頭連合野の代謝低下はアミロイド沈着によらない

  石井 一成; 兵頭 朋子; 坂口 健太; 花岡 宏平; 宇佐美 公男; 島元 健次; 山添 譲; 山田 穣; 松木 充; 細野 眞; 村上 卓道

  核医学 (一社)日本核医学会 49 (4) 435 - 435 0022-7854 2012/11
• 認知症における脳FDG‐PET早期撮像の可能性について

  兵頭朋子; 石井一成; 坂口健太; 花岡宏平; 宇佐美公男; 島元健次; 山添譲; 山田穣; 松木充; 細野眞; 村上卓道

  核医学 (一社)日本核医学会 49 (3) S274 - S274 0022-7854 2012/08
• SPECT/CTを用いたバセドウ病のヨウ素131治療計画

  細野眞; 花岡宏平; 米矢吉宏; 土屋典生; 坂口健太; 高田裕史; 森元英夫; 宇佐美公男; 石井一成

  核医学症例検討会症例集 33 (1) 15-16  0910-2213 2012/08
• Antiangiogenic Tumor Therapy by DNA Vaccine Inducing Aquaporin-1-Specific CTL Based on Ubiquitin-Proteasome System in Mice

  Bin Chou; Kenji Hiromatsu; Shinji Okano; Kazunari Ishii; Xuefeng Duan; Tohru Sakai; Shigeo Murata; Keiji Tanaka; Kunisuke Himeno

  JOURNAL OF IMMUNOLOGY AMER ASSOC IMMUNOLOGISTS 189 (4) 1618 - 1626 0022-1767 2012/08 [Refereed]
   

  Aquaporin-1 (AQP-1) is a water channel protein highly expressed in the vascular endothelial cells of proliferating tissues including malignant cancers. Given that in APC ubiquitinated peptides are effectively introduced into proteasomes from which CD8 epitopes are excised, we fused ubiquitin with AQP-1 (pUB-AQP-1) to produce a DNA vaccine. In C57BL/6J mice immunized with pUB-AQP-1, the growth of B16F10 melanoma was profoundly inhibited. The antitumor effect of the pUB-AQP-1 DNA vaccine was largely mediated by CD8 T cells, which secrete IFN-gamma, perforin, and granzyme-B in the presence of APCs transfected with pUB-AQP-1. AQP-1-specific CD8 T cells possessed cytotoxic activity both in vivo and in vitro. After tumor challenge, the microvessel density decreased and the ratio of total blood vessel area to tumor area was significantly reduced as compared with control mice, resulting in a dramatic suppression of tumor growth. The immunization effect was completely abrogated in immunoproteasome-deficient mice. Strikingly this pUB-AQP-1 DNA vaccine was also effective against Colon 26 colon tumors (BALB/c) and MBT/2 bladder tumors (C3H/HeN). Thus, this ubiquitin-conjugated DNA immunization-targeting tumor vasculature is a valid and promising antitumor therapy. This vaccine works across the barriers of tumor species and MHC class I differences in host mice. The Journal of Immunology, 2012, 189: 1618-1626.
• Estimation of liver function using T2* mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging

  Takashi Katsube; Masahiro Okada; Seishi Kumano; Izumi Imaoka; Yuki Kagawa; Masatoshi Hori; Kazunari Ishii; Noboru Tanigawa; Yasuharu Imai; Masatoshi Kudo; Takamichi Murakami

  EUROPEAN JOURNAL OF RADIOLOGY ELSEVIER IRELAND LTD 81 (7) 1460 - 1464 0720-048X 2012/07 [Refereed]
   

  Purpose: To investigate the usefulness of T2* mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for estimating liver function. Materials and methods: 33 patients were classified into 3 groups as follows: normal liver function (NLF) (n = 7); mild liver damage (MLD) (n = 16) with Child-Pugh A; severe liver damage (SLD) (n = 10) with Child-Pugh B. T2*-weighted gradient-echo (T2* W-GRE) and T1-weighted gradient-echo (T1W-GRE) images were obtained before and after Gd-EOB-DTPA administration (3, 8, 13, and 18 min; 5, 10,15, and 20 min; respectively). T2* mapping of liver was calculated from T2* W-GRE, then T2* values of liver and T2* reduction rates of T2* value between pre-and post-contrast enhancement were measured. The increase rates of liver-to-muscle signal intensity (LMS) ratio on T1W-GRE between pre-and post-contrast enhancement were calculated. Results: T2* values on pre-and post-contrast showed no significant differences among three groups. Significant differences in T2* reduction rates were found among groups, and those of LCB were lower than those of other groups (NLF: MLD: SLD, 3.8: 6.0: 0.6% at 3 min, 8.2: 10.3: 1.0% at 8 min, 10.7: 11.5: 1.2% at 13 min, and 16.1: 13.2: 3.5% at 18 min, respectively) (P < 0.05). Significant differences in increase rates of LMS ratio on T1W-GRE were identified (NLF: MLD: SLD, 1.53: 1.46: 1.35 at 5 min, 1.68: 1.64: 1.37 at 10 min, 1.79: 1.76: 1.44 at 15 min, and 1.89: 1.78: 1.49 at 20 min, respectively). Conclusion: T2* reduction rate and increase rate of LMS ratio on T1W-GRE may allow us estimation of liver function according to Child-Pugh score. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
• Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?

  Masahiro Okada; Kazunari Ishii; Kazushi Numata; Tomoko Hyodo; Seishi Kumano; Masayuki Kitano; Masatoshi Kudo; Takamichi Murakami

  HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL ZHEJIANG UNIV SCH MEDICINE 11 (3) 307 - 313 1499-3872 2012/06 

  BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child-Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1-weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin >= 1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffes post-hoc test after two-way repeated-measures ANOVA and Pearson's correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes, significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio. CONCLUSIONS: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB-DTPA.
• Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?

  Masahiro Okada; Kazunari Ishii; Kazushi Numata; Tomoko Hyodo; Seishi Kumano; Masayuki Kitano; Masatoshi Kudo; Takamichi Murakami

  HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL ZHEJIANG UNIV SCH MEDICINE 11 (3) 307 - 313 1499-3872 2012/06 [Refereed]
   

  BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child-Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1-weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin >= 1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffes post-hoc test after two-way repeated-measures ANOVA and Pearson's correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes, significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio. CONCLUSIONS: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB-DTPA.
• Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?

  Masahiro Okada; Kazunari Ishii; Kazushi Numata; Tomoko Hyodo; Seishi Kumano; Masayuki Kitano; Masatoshi Kudo; Takamichi Murakami

  HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL ZHEJIANG UNIV SCH MEDICINE 11 (3) 307 - 313 1499-3872 2012/06 [Refereed]
   

  BACKGROUND: Excretion of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients. METHODS: Forty patients [group 1: normal liver and Child-Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1-weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin <1.8 mg/dL) and group 4 (total bilirubin >= 1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffes post-hoc test after two-way repeated-measures ANOVA and Pearson's correlation test were used for statistical analysis. RESULTS: Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes, significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio. CONCLUSIONS: The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB-DTPA.
• T2*relaxometry mapping of the uterine zones

  Izumi Imaoka; Takayuki Nakatsuka; Tetsuro Araki; Takashi Katsube; Masahiro Okada; Seishi Kumano; Kazunari Ishii; Ryuichiro Ashikaga; Tomoyuki Okuaki; Marc Van Cauteren; Takamichi Murakami

  ACTA RADIOLOGICA ROYAL SOC MEDICINE PRESS LTD 53 (4) 473 - 477 0284-1851 2012/05 [Refereed]
   

  Background: Previous literature demonstrated that the T2* value of the uterine junctional zone was lower than that of peripheral myometrium by using BOLD MR imaging. We expect T2* mapping image may add more information to T2-weighted images of the uterine myometrium. Purpose: To evaluate whether T2* mapping software would reproduce the result of previous report, and to apply the software to benign uterine diseases. Material and Methods: Five healthy volunteers and 19 patients clinically suspected of having benign pelvic disease were imaged using a 1.5T MR system. All women were of reproductive age, and all provided informed consent. Sagittal T2* images using a multishot EPI sequence were obtained. T2* values were calculated and color T2* maps reconstructed using a T2* fitting tool. Results: The uterine zones could be identified in all 24 examinations on the T2* maps. In addition, a thin "4th zone" was seen between the endometrium and the JZ (junctional zone) in 19 of 24 examinations. The T2* value of JZ was significantly lower than that of peripheral myometrium (PM) (P < 0.001). No significant difference in the T2* value of the JZ or of PM was noted between normal uterus and uterus with leiomyomas and/or adenomyosis. Conclusion: A quantitative T2* map can easily be obtained using the PRIDE software T2* fitting tool, and the software reproduces the result from previous report. T2* value of the junctional zone was lower than that of peripheral myometrium regardless of having benign myometrial diseases.
• Impact of CT attenuation correction by SPECT/CT in brain perfusion images

  Kazunari Ishii; Kohei Hanaoka; Masahiro Okada; Seishi Kumano; Yoshihiro Komeya; Norio Tsuchiya; Makoto Hosono; Takamichi Murakami

  ANNALS OF NUCLEAR MEDICINE SPRINGER 26 (3) 241 - 247 0914-7187 2012/04 [Refereed]
   

  The aim of this study was to elucidate the regional differences between brain perfusion single photon emission computed tomography (SPECT) images reconstructed with a uniform attenuation correction using Chang's method (AC-Chang) and a non-uniform attenuation correction with CT using SPECT/CT (AC-CT). SPECT images of a phantom with and without head holder were obtained, and reconstructed images of AC-Chang and AC-CT were compared. Twenty-eight consecutive patients with brain disease examined by SPECT/CT brain perfusion imaging were selected, and images were reconstructed with AC-Chang and AC-CT. The AC-Chang and AC-CT reconstructed images were then compared by voxel-based analysis using three-dimensional stereotactic surface projections. Counts in the frontal area of the AC-Chang phantom image with head holder were higher than those in the posterior area. Counts in the frontal area of the AC-Chang clinical images were significantly higher than those in the AC-CT images, while the counts in the margin of the frontal lobe and posterior margin of the parietal, occipital cortices and cerebellum of the AC-Chang images were significantly lower. Relative frontal perfusion was 5.0% higher and relative cerebellar perfusion was 4.6% lower in the AC-Chang images relative to the AC-CT images, on average. We demonstrated the frontal dominant hyper-perfusion and parieto-occipital and cerebellar hypo-perfusion in brain SPECT images reconstructed with AC-Chang compared to those reconstructed with AC-CT. We suggest that to obtain an accurate attenuation-corrected brain perfusion SPECT image, attenuation correction by Chang's method is inadequate.
• ¹³¹I甲状腺内用療法におけるSPECT/CTを用いた甲状腺重量測定について

  花岡宏平; 大塚正和; 吉田修平; 井上亮; 石井一成; 村上卓道; 細野眞

  日本放射線技術学会総会学術大会予稿集 (公社)日本放射線技術学会 68回 185 - 186 1884-7846 2012/02
• 脳FDG集積低下を示す大きな腫瘍代謝症例の分析

  細野眞; 花岡宏平; 米矢吉宏; 土屋典生; 宇佐美公男; 高田裕史; 坂口健太; 森元英夫; IM Sung‐Woon; 石井一成; 辰巳陽一; 下野太郎

  核医学症例検討会症例集 32 (2) 41-42  0910-2213 2012/02
• Can the biliary enhancement of Gd-EOB-DTPA predict to the degree of live r function ?

  岡田 真広; 石井 一成; 村上 卓道

  Hepatobiliary & Pancreatic Diseases International 2012
• Correlation of right frontal hypoperfusion and urinary dysfunction in iNPH: A SPECT study

  Ryuji Sakakibara; Yoshitaka Uchida; Kazunari Ishii; Hiromitsu Kazui; Masaaki Hashimoto; Masaaki Ishikawa; Tatsuhiko Yuasa; Masahiko Kishi; Emina Ogawa; Fuyuki Tateno; Tomoyuki Uchiyama; Tatsuya Yamamoto; Tomonori Yamanishi; Hitoshi Terada

  NEUROUROLOGY AND URODYNAMICS WILEY 31 (1) 50 - 55 0733-2467 2012/01 [Refereed]
   

  Objectives To elucidate the pathophysiology of urinary dysfunction in idiopathic normal-pressure hydrocephalus (iNPH) by single-photon emission computed tomography (SPECT) and statistical brain mapping. Methods: Urinary symptoms were observed and N-isopropyl-p-[I-123]-iodoamphetamine (IMP)-SPECT imaging was performed in 97 patients with clinico-radiologically definite iNPH. The patients included 56 men and 41 women; mean age, 74 years. The statistical difference in normalized mean tracer counts was calculated and visualized between patients with urinary dysfunction of severer degrees (>grade 2/4) and milder degrees (
• Inclusion criteria provide heterogeneity in baseline profiles of patients with mild cognitive impairment: comparison of two prospective cohort studies.

  Shoji Kawashima; Kengo Ito; Takashi Kato

  BMJ open 2 (2) e000773  2012 

  BACKGROUND: Mild cognitive impairment (MCI) is considered to represent a transitional stage between ageing and Alzheimer's disease (AD). To aim at identifying neuroimaging measures associated with cognitive changes in healthy elderly and MCI patients, longitudinal multicentre studies are ongoing in several countries. The patient profiles of each study are based on unique inclusion criteria. OBJECTIVES: The purpose of the study is to clarify differences in baseline profiles of MCI patients between Studies on Diagnosis of Early Alzheimer's Disease-Japan (SEAD-J) and Alzheimer's Disease Neuroimaging Initiative (ADNI) and to examine the association between baseline profiles and risk of early conversion to AD. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: SEAD-J recruited 114 patients from nine facilities in Japan. A total of 200 patients in ADNI with fluorodeoxyglucose-positron emission tomography (FDG-PET) were enrolled from the USA. METHODS: Baseline profiles were statistically analysed. For FDG-PET at a time of inclusion, associations between each profile and cerebral metabolic rate for glucose (CMRgl) were examined using SPM5 software. In each study, the ratio of conversion to AD within the 1-year and 2-year period after inclusion was investigated and differences in baseline profiles between AD converters and non-converters were analysed. RESULTS: SEAD-J included MCI patients with more severe verbal memory deficits and extracted patients with higher depressive tendencies. These differences were likely to be associated with criteria. SEAD-J exhibited a higher rate of conversion within 1 year compared with ADNI (24.5% vs 13.5%). In FDG-PET analyses of SEAD-J, AD converters within 1 year showed more severe decrease of FDG uptake in bilateral inferior parietal regions compared with non-converters. CONCLUSIONS: Different inclusion criteria provided differences in baseline profiles. The severity of memory deficit might cause increase of the AD conversion within 1 year. Clinical outcomes of multicentre studies for early diagnosis of AD should be interpreted carefully considering profiles of patients.
• ¹⁸F‐FDG PET/CTにてsuperscanを呈した腎癌骨転移の1例

  兵頭朋子; 石井一成; 細野眞; 阪本祐一; 米矢吉宏; 柳生行伸; 土屋典生; 熊野正士; 足利竜一朗; 中村一郎; 植村天受; 村上卓道

  核医学 (一社)日本核医学会 48 (4) 471 - 471 0022-7854 2011/11
• Human leukocyte antigen class I polymorphisms influence the mild clinical manifestation of Plasmodium falciparum infection in Ghanaian children

  Akiko Yamazaki; Michio Yasunami; Michael Ofori; Hitomi Horie; Mihoko Kikuchi; Gideon Helegbe; Akiko Takaki; Kazunari Ishii; Ahmeddin Hassan Omar; Bartholomew D. Akanmori; Kenji Hirayama

  HUMAN IMMUNOLOGY ELSEVIER SCIENCE INC 72 (10) 881 - 888 0198-8859 2011/10 [Refereed]
   

  A prospective study that included 429 children for active detection of mild malaria was conducted in a coastal region of Ghana to reveal whether the incidence of malaria is affected by human leukocyte antigen (HLA) polymorphism. During 12 months of follow-up, 85 episodes of mild clinical malaria in 74 individuals were observed, and 34 episodes among them were accompanied with significant parasitemia at >5000 infected red blood cells per cubic millimeter. Attributable and relative risks conferred by genetic factors in the HLA region were evaluated by comparison of the incidence in children, stratified by carrier status, of a given allele of HLA-A, -B, -DRB1 and TNFA promoter polymorphism. HLA-B*35:01 reduced the incidence by 0.178 events per person per year (0.060 versus 0.239 for B*35:01-positive and -negative subpopulations, respectively), and a relative risk of 0.25, which remained statistically significant after Bonferroni's correction for multiple testing (p(c) = 8.2 x 10(-5)). Further, HLA-B*35:01 and -B*53:01 exhibited opposite effects on the incidence of malaria with significant parasitemia. When parasite densities in different HLA carriers status were compared, HLA-A*01 conferred an increase in parasite load (p = 6.0 x 10(-7)). In addition, we found a novel DRB1 allele that appears to have emerged from DRB1*03:02 by single nucleotide substitution. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
• Fluorodeoxyglucose uptake in the bone marrow after granulocyte colony-stimulating factor administration in patients with non-Hodgkin's lymphoma

  Kohei Hanaoka; Makoto Hosono; Kimio Usami; Yoichi Tatsumi; Yuzuru Yamazoe; Yoshihiro Komeya; Norio Tsuchiya; Kazunari Ishii; Mitsugu Sumita

  NUCLEAR MEDICINE COMMUNICATIONS LIPPINCOTT WILLIAMS & WILKINS 32 (8) 678 - 683 0143-3636 2011/08 [Refereed]
   

  Purpose To clarify the change in the fluorodeoxyglucose (FDG) uptake by the bone marrow over time after administration of granulocyte colony-stimulating factor (G-CSF), we evaluated the correlation between the interval from the last day of administration of G-CSF to positron emission tomography/computed tomography (PET/CT) study and spinal bone marrow accumulation in patients with non-Hodgkin's lymphoma. Methods A total of 127 patients with confirmed non-Hodgkin's lymphoma who underwent FDG PET within 60 days from the last administration of G-CSF were retrospectively reviewed. Thirty age-matched and sex-matched healthy controls were also included to evaluate physiological FDG uptake. PET/CT examinations were retrospectively reviewed, and maximum standardized uptake value (SUV(max)) was measured by placing volumetric regions of interest over each thoracic and lumbar vertebra on PET images referring to CT images. Bone marrow SUV was defined as the mean SUV(max) of the vertebra. The correlation between the interval after G-CSF and the bone marrow SUV was plotted and analyzed with polynomial approximation. Results In controls, physiological bone marrow SUV of the spine was determined. In patients with lymphoma, bone marrow SUV decreased over time and reached a plateau at about 14 days after G-CSF administration, and this was higher by 5% than the plateau at 10 days. SUV declined to the 'physiological range', that is, mean+ 1 standard deviation of patients, at about 7 days. Conclusion For a PET/CT study, an interval of 10 days after G-CSF administration is recommended to minimize the influence of G-CSF on the bone marrow when evaluating treatment response in patients with non-Hodgkin's lymphoma. Nucl Med Commun 32:678-683 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
• Gender and Age Differences in Normal Adult Human Brain: Voxel-Based Morphometric Study

  Ryuichi Takahashi; Kazunari Ishii; Tatsuya Kakigi; Kazumasa Yokoyama

  HUMAN BRAIN MAPPING WILEY-BLACKWELL 32 (7) 1050 - 1058 1065-9471 2011/07 [Refereed]
   

  The aim of this study was to evaluate the gender and age differences in the normal adult human brain, using voxel-based morphometry. In this study, 227 right-handed normal adults (male: female 111: 116) were examined. Three-dimensional magnetic resonance brain images of each subject were segmented into gray and white matter using statistical parametric mappings. All individual data were transformed to standard brain space and then divided into older and younger age groups before examining the effects of age and gender. There was a significant negative correlation between gray matter concentration and age in each gender group. The differences were more prominent in the older age groups compared with the younger age groups. Gray matter concentrations in the bilateral inferior frontal lobes, anterior cingulate gyrus, medial thalamus, and hypothalamus were more retained in females as they aged, whereas those in the occipital regions were more retained in aging males. Our findings are consistent with biologically and hormonally established gender differences. Hum Brain Mapp 32: 1050-1058, 2011. (C) 2010 Wiley-Liss, Inc.
• Unenhanced fat fraction ratios obtained by MR and enhanced T2*values with liver-specific MR contrast agents for diagnosis of non-alcoholic steatohepatitis in rats

  Masahiro Okada; Takashi Katsube; Seishi Kumano; Yuki Kagawa; Tetsuro Araki; Natsuko Tsuda; Tomoyuki Okuaki; Izumi Imaoka; Noboru Tanigawa; Kazunari Ishii; Takamichi Murakami

  ACTA RADIOLOGICA ROYAL SOC MEDICINE PRESS LTD 52 (6) 658 - 664 0284-1851 2011/07 [Refereed]
   

  Background: Non-invasive MR imaging is expected to be used for accurate diagnosis and quantification of non-alcoholic steatohepatitis (NASH), because NASH is a progressive fatty liver disease. New MR techniques, such as fat fraction ratio (FFR) and T2* value measurement, have attracted an increasing attention, because those techniques can measure quantitative parameters of fibrosis, fat and iron deposition in the liver. Purpose: To investigate the potential of FFR and T2* value in NASH with pre-enhancement, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) or super-paramagnetic iron oxide (SPIO)-enhanced MRI. Material and Methods: Twenty-eight rats were divided equally into four groups (one control group and three NASH groups). All rats underwent unenhanced, Gd-EOB-DTPA, and SPIO-enhanced MRI. The T2* value of the liver was measured for each image sequence, and then changes in T2* values before and after each injection were analyzed using Dunnett's test. The reduction rate of T2* value before and 13 min after injection of Gd-EOB-DTPA or SPIO was analyzed using Mann-Whitney's U test. Moreover, FFR of the liver was measured before enhancement, and the relationship between fat fraction and the calculated fat area percentage on a pathological specimen was examined using Spearman's correlation test. Results: On pre-enhancement, FFR and T2* value were 26.0% +/- 12.0% and 21.5 +/- 4.2 ms for all NASH groups, and 0.9% +/- 0.5% and 30.8 +/- -5.5 ms for control, respectively. Both FFR and T2* values were significantly different between the NASH and control groups. The reduction rate of T2* value was significantly lower in the NASH groups than in the control group on SPIO-enhanced MRI, though there was no significant difference on Gd-EOB-DTPA-enhanced MRI. FFR was correlated with the calculated fat area percentage for the pathological specimen. Conclusion: Pre-enhancement FFR, T2* value measurement and reduction rate of T2* value on SPIO-enhanced MRI may help estimate the progress of liver fat deposition and fibrosis in NASH.
• Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT

  Kazunari Ishii; Takafumi Uemura; Naokazu Miyamoto; Toshiki Yoshikawa; Toshiaki Yamaguchi; Tatsuhiko Ashihara; Yukihiro Ohtani

  ANNALS OF NUCLEAR MEDICINE SPRINGER 25 (4) 255 - 260 0914-7187 2011/05 [Refereed]
   

  The graph plot method, a technique that uses N-isopropyl-(123)I-p-iodoamphetamine (IMP) and single photon emission computed tomography (SPECT) for non-invasive measurement of regional cerebral blood flow (CBF), has been developed and applied in the clinical setting, although it has been performed without obtaining normal CBF values in normal, healthy subjects. The aim of this study was to measure normal regional CBF in older healthy subjects with IMP SPECT and the graph plot method. Eleven healthy volunteers (mean age: 63.5 +/- A 8.9 years; six males and five females) were recruited and regional CBF was measured using IMP SPECT and the graph plot method. The averaged global CBF was 45.4 ml/100 g/min. The distribution of regional CBF was almost homogenous in the cortices. There was no significant correlation between the global CBF and age in subjects aged 50-80 years. We used the IMP graph plot method to measure regional CBF in normal healthy subjects, without arterial blood sampling, and obtained compatible CBF values. This method is non-invasive and convenient for determination of regional CBF in the clinical setting.
• Interrater variability of image interpretation for F-18-FDG and C-11-PIB PET in the diagnosis of Alzheimer's disease

  Tomohiko Yamane; Hidehito Nagai; Tomoyuki Nishio; Yasuhiko Ikari; Yoko Makishi; Kazunari Ishii; Kenji Ishii; Takashi Kato; Kengo Ito; Michio Senda

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 52 0161-5505 2011/05
• Estimation of Liver Function Using T1 Mapping on Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging

  Takashi Katsube; Masahiro Okada; Seishi Kumano; Masatoshi Hori; Izumi Imaoka; Kazunari Ishii; Masatoshi Kudo; Hajime Kitagaki; Takamichi Murakami

  INVESTIGATIVE RADIOLOGY LIPPINCOTT WILLIAMS & WILKINS 46 (4) 277 - 283 0020-9996 2011/04 [Refereed]
   

  Objectives: To investigate the ability of T1 mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the estimation of liver function. Materials and Methods: Local institutional review board approved this study. Ninety-one patients (64 men, 27 women; mean age, 67.4 years) were classified into 4 groups as follows: normal liver function (NLF), n = 16; chronic hepatitis (CH), n = 38; liver cirrhosis with Child-Pugh A (LCA), n = 20; and liver cirrhosis with Child-Pugh B (LCB), n = 17. Look-Locker sequences (single slice multiphase imaging using gradient-echo sequence with inversion recovery pulse) were obtained before and at 3, 8, 13, and 18 minutes after Gd-EOB-DTPA administration. T1 mapping of liver parenchyma was calculated from the Look-Locker sequence. T1 relaxation time of liver and reduction rate of T1 relaxation time between pre- and postcontrast enhancement were measured. The Bonferroni t test was used for comparisons between the 4 groups. Results: Precontrast T1 relaxation times were significantly longer for LCA and LCB than for NLF, and that of LCB was longer than that of chronic hepatitis (P < 0.05). Postcontrast T1 relaxation times were significantly longer for LCB than for other groups at all time points. Those of LCA were longer than those of NLF at all time points. Reduction rates were significantly lower for LCB than for the other groups at >= 8 minutes. Conclusions: Evaluation of hepatic uptake of Gd-EOB-DTPA using T1 mapping of liver parenchyma can help estimate liver function.
• Optimal Scanning Protocol of Arterial Dominant Phase for Hypervascular Hepatocellular Carcinoma with Gadolinium-Ethoxybenzyl-Diethylenetriamine Pentaacetic Acid-Enhanced MR

  Yuki Kagawa; Masahiro Okada; Seishi Kumano; Takashi Katsube; Izumi Imaoka; Noboru Tanigawa; Kazunari Ishii; Masatoshi Kudo; Takamichi Murakami

  JOURNAL OF MAGNETIC RESONANCE IMAGING WILEY-BLACKWELL 33 (4) 864 - 872 1053-1807 2011/04 [Refereed]
   

  Purpose: To investigate optimal delay time of hepatic arterial phase in Gadoxetate-enhanced MR for detecting hypervascular hepatocellular carcinoma (HCC). Materials and Methods: Forty-five patients with 85 hypervascular HCCs and 9 patients with 16 hypervascular HCCs underwent Gadoxetate-and Gd-DTPA-enhanced MR at 1.5 Tesla (T) system, respectively. All HCCs were analyzed 10-38 s after injection using a time-resolved dynamic MR sequence with keyhole data sampling. Seven sequential phase images (1 phase 4 s) were obtained during a single breath hold of 28 s. Time-intensity curves of the abdominal aorta, liver parenchyma, and HCC were obtained, then aortic contrast arrival time, time of peak HCC enhancement, duration time of HCC and aortic enhancement, and time delay from aortic contrast arrival to peak enhancement of HCC were measured. Results: Aortic contrast arrival time was 15.1 +/- 2.9 s, time of peak HCC enhancement 29.9 +/- 4.6 s, duration time of HCC enhancement 17.4 +/- 6.4 s postinjection of Gadoxetate. Duration of aortic enhancement (23.6 +/- 3.5 s) of Gadoxetate-enhanced MR was significantly less than that of Gd-DTPA-enhanced MR (26.3 +/- 2.8 s) (P < 0.0059). Conclusion: Peak enhancement time of HCC on Gadoxetate-enhanced MR imaging occurred at 14.6 +/- 4.6 s after aortic contrast arrival.
• Computer-Assisted System for Diagnosis of Alzheimer Disease Using Data Base-Independent Estimation and Fluorodeoxyglucose-Positron-Emission Tomography and 3D-Stereotactic Surface Projection

  T. Uemura; K. Ishii; N. Miyamoto; T. Yoshikawa

  AMERICAN JOURNAL OF NEURORADIOLOGY AMER SOC NEURORADIOLOGY 32 (3) 556 - 559 0195-6108 2011/03 [Refereed]
   

  BACKGROUND AND PURPOSE: Recently, voxel-based statistical parametric images have been developed as additional diagnostic tools for AD. However these methods require the generation of a data base of healthy brain images. The purpose of this study was to produce and evaluate an automatic method using a data base independent estimation system for the diagnosis of mild AD. MATERIALS AND METHODS: We retrospectively selected 66 subjects, including 33 patients with early AD and 33 age-matched healthy volunteers. Individual brain metabolic images were obtained by using FDG-PET. These were transformed by using 3D-SSP. We then produced CADDIES, which compares the parietal and sensorimotor metabolic counts by using t tests. If parietal metabolism was significantly lower than the sensorimotor metabolism, the subject was automatically diagnosed as having AD. The FDG-PET images were also analyzed by using a previous automatic diagnosis system (CAAD) that is dependent on the construction of a "normal data base" of healthy brain images. Diagnostic performance was compared between the 2 methods. RESULTS: The CADDIES demonstrated a sensitivity of 88%, specificity of 79%, and accuracy of 85%, while the CAAD system demonstrated a sensitivity of 70%, specificity of 94%, and accuracy of 82%. The area under the ROC curve of CADDIES was 0.964. The areas under ROC curves of the CAAD method in the parietal and posterior cingulate gyri were 0.843 and 0.939, respectively. CONCLUSIONS: The CADDIES method demonstrated a diagnostic accuracy similar to that of the CAAD system. Our results indicate that this method can be applied to the detection of patients with early AD in routine clinical examinations, with the benefit of not requiring the generation of a normal data base.
• 【All About Gd-EOB-DTPA MRI】転移性肝腫瘍診断における有用性

  朝戸 信行; 岡田 真広; 熊野 正士; 藤谷 哲也; 柳生 行伸; 柏木 伸夫; 小塚 健倫; 今岡 いずみ; 足利 竜一朗; 石井 一成; 村上 卓道

  臨床画像 (株)メジカルビュー社 27 (3) 342 - 347 0911-1069 2011/03
• 呼吸同期装置を用いない呼吸同期SPECT法の検討

  坂口 健太; 高田 裕史; 宇佐美 公男; 米矢 吉宏; 土屋 典生; 熊野 正士; 細野 眞; 花岡 宏平; 大塚 正和; 井上 亮; 新谷 祐子; 吉田 修平; 森元 英夫; 宇都 辰郎; 澄田 貢; 柿木 崇秀; 柳生 行伸; 石井 一成; 足利 竜一郎; 村上 卓道

  核医学 (一社)日本核医学会 48 (1) 63 - 64 0022-7854 2011/02
• Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging.

  高橋 竜一; 石井 一成; 村上 卓道; 横山 和正; 柿木 達也; 森 悦朗

  Dement Geriatr Cogn Dis Extra 1 381 - 392 2011
• Neuroanatomy of a neurobehavioral disturbance in the left anterior thalamic infarction

  Yoshiyuki Nishio; Mamoru Hashimoto; Kazunari Ishii; Etsuro Mori

  Journal of Neurology, Neurosurgery and Psychiatry BMJ Publishing Group 82 (11) 1195 - 1200 1468-330X 2011 [Refereed]
   

  Background and purpose: Cognitive and behavioural symptoms represent primary clinical manifestations of anterior thalamic infarcts (ATIs) in the tuberothalamic artery territory. The aim of the study is to understand the pathomechanism of cognitive and behavioural disturbances in left ATI (LATI). Methods: 6 patients with isolated LATIs were investigated using neuropsychological assessments, MRI stereotactic lesion localisation and positron emission tomography. Results: The patients were characterised clinically by verbal memory impairment, language disturbances dominated by anomia and word-finding difficulty and apathy. The ventral anterior nucleus (VA) proper, magnocellular VA (VAmc), ventral lateral anterior nucleus (VLa), ventral lateral posterior nucleus (VLp) and mammillothalamic tract were involved in all patients. Compared with healthy controls, the regional cerebral blood flow was lower in the thalamus, the dorsolateral, medial and orbital frontal lobes, the anterior temporal lobe, the inferior parietal lobule and the occipital lobe of the left hemisphere. Conclusions: The authors propose that the Papez circuit disruption at the mammillothalamic tract and possibly thalamomedial temporal disconnection at the VA region is responsible for memory impairment and that the thalamo-anterior temporal disconnection is associated with language disturbance in LATI, respectively.
• A Multicenter Brain Perfusion SPECT Study Evaluating Idiopathic Normal-Pressure Hydrocephalus on Neurological Improvement

  Kazunari Ishii; Masaaki Hashimoto; Kohei Hayashida; Kazuo Hashikawa; Chia-Cheng Chang; Jyoji Nakagawara; Teiji Nakayama; Satoru Mori; Ryuji Sakakibara

  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS KARGER 32 (1) 1 - 10 1420-8008 2011 [Refereed]
   

  Purpose: This study was designed to investigate the specific cerebral blood flow (CBF) pattern in patients with idiopathic normal-pressure hydrocephalus (iNPH) and a predictive value for shunt responsiveness in a multicenter study (Study of Idiopathic Normal-Pressure Hydrocephalus on Neurological Improvement: SINPHONI). Methods: Eighty-four iNPH patients underwent shunt operations using MRI selection criteria from the SINPHONI and were subjected to CBF single photon emission computed tomography (SPECT). The perfusion patterns on SPECT were classified: anterior-dominant CBF reduction type (A type), posterior-dominant CBF reduction type (P type), and mixed or diffuse CBF reduction type (M type). The predictive value of the CBF pattern for favorable shunt outcome was evaluated. Results: Favorable outcomes were obtained in 76% (64/84) of patients, and shunt responsiveness was achieved in 85% (71/84) of patients. Areas of severely reduced relative CBF were demonstrated around the corpus callosum and in the sylvian fissure area, which included the effects of dilatations of the ventricles and sylvian fissures and relatively increased perfusion in the medial and lateral frontal, parietal, and occipital areas at high convexity. Forty-nine (58%) cases were A type, 25 (30%) cases were M type, and 10 (12%) cases were P type. A, M, and P type cases exhibited 83, 84, and 90% positive predictive values for shunt responsiveness, respectively. Mean modified Rankin scale and Mini-Mental State Examination scores of the A type group were significantly better than those of other groups. Conclusion: The iNPH patients showed various patterns of CBF reduction, but there was no significant difference in the predictive value among the three patterns, though CBF reduction patterns may suggest a severe condition of iNPH. Copyright (C) 2011 S. Karger AG, Basel
• Brain alterations and mini-mental state examination in patients with progressive supranuclear palsy: voxel-based investigations using f-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging.

  Takahashi R; Ishii K; Kakigi T; Yokoyama K; Mori E; Murakami T

  Dementia and geriatric cognitive disorders extra 1 1 (1) 381 - 392 2011/01 [Refereed]
  
• 【肝画像診断 US・CT・MRIのNext Stage】マルチスライスCTによる肝画像診断の進歩 高速化・高分解能化の動向

  岡田 真広; 香川 祐毅; 熊野 正士; 柳生 行伸; 任 誠雲; 今岡 いずみ; 足利 竜一朗; 石井 一成; 山田 浩司; 工藤 正幸; 工藤 正俊; 村上 卓道

  肝胆膵画像 (株)医学書院 13 (1) 37 - 44 1882-5087 2011/01 

  近年のMDCTは進歩がめざましく,高空間分解能,高時間分解能画像を容易に得られるが,検出器の多列化競争は一段落した感がある.CTの原理上,被曝を完全になくすことはできないが,被曝低減を意識した肝dynamic CT検査は重要である.造影剤投与プロトコール(造影剤注入量や注入速度,scan delay)最適化も重要であり,MDCTの出現により動脈相を2回撮影(double arterial phase)する方法が可能となったが,筆者らが用いている最新のMDCT(VCT-Vision,GE Healthcare社)では,肝を多相性撮影する(たとえば12相の動脈相を得る)ことが可能であり,肝動脈相をほぼリアルタイムに得られるようになった.これをVHSと称する.(著者抄録)
• Decreased brain FDG uptake in patients with extensive non-Hodgkin's lymphoma lesions

  Kohei Hanaoka; Makoto Hosono; Taro Shimono; Kimio Usami; Yoshihiro Komeya; Norio Tsuchiya; Yuzuru Yamazoe; Kazunari Ishii; Youichi Tatsumi; Mitsugu Sumita

  ANNALS OF NUCLEAR MEDICINE SPRINGER 24 (10) 707 - 711 0914-7187 2010/12 [Refereed]
   

  Faint brain [(18)F]fluoro-2-deoxyglucose (FDG) uptake has sporadically been reported in patients with FDG-avid large or diffusely extended tumors. The purpose of this study was to investigate whether there is a correlation between massive tumor uptake and decreased brain uptake on FDG positron emission tomography/computed tomography (PET/CT). Sixty-five patients with histologically confirmed non-Hodgkin's lymphoma who underwent FDG-PET/CT were enrolled. Thirty control subjects were also included to evaluate normal brain FDG uptake. PET/CT examinations were retrospectively reviewed. The volumetric regions of interest were placed over lesions by referring to CT and PET/CT fusion images to measure mean standardized uptake value (SUVavg). The products of SUVavg and tumor volume were calculated as total glycolytic volume (TGV). The maximum SUV (SUVmax) and SUVavg were measured in the cerebrum and cerebellum. The values of TGV and brain FDG uptake were plotted and analyzed with a linear regression method. In the lymphoma patients, there were statistically significant negative correlations between TGV and brain SUVs. Demonstrating a significant negative correlation between TGV and brain uptake validated the phenomenon of decreased brain FDG uptake. Diversion of FDG from the brain to the lymphoma tissue may occur during the FDG accumulation process. Recognition of this phenomenon prevents unnecessary further neurological examinations in such cases.
• Measurement of Gray and White Matter Atrophy in Dementia with Lewy Bodies Using Diffeomorphic Anatomic Registration through Exponentiated Lie Algebra: A Comparison with Conventional Voxel-Based Morphometry

  R. Takahashi; K. Ishii; N. Miyamoto; T. Yoshikawa; K. Shimada; S. Ohkawa; T. Kakigi; K. Yokoyama

  AMERICAN JOURNAL OF NEURORADIOLOGY AMER SOC NEURORADIOLOGY 31 (10) 1873 - 1878 0195-6108 2010/11 [Refereed]
   

  BACKGROUND AND PURPOSE: DLB is recognized as the second major form of dementia in the elderly. The regional pattern of GM atrophy in DLB highly overlaps that in AD. The aim of this study was to identify the critical pattern of atrophy in DLB by using DARTEL, which provides improved registration accuracy compared with that of conventional VBM. MATERIALS AND METHODS: We evaluated 51 patients with probable AD, 43 patients with probable DLB, and 40 age-matched healthy controls. The pattern of GM atrophy in each group was compared by using conventional VBM and VBM-DARTEL. RESULTS: Regional patterns of atrophy identified by using conventional VBM differed significantly from those identified by using VBM-DARTEL. A decrease in GM volume in the MTLs in both AD and DLB was identified with VBM-DARTEL; the decrease was greater in patients with AD than in those with DLB. Comparisons with healthy controls revealed that the WM volume of the whole brain was preserved in patients with DLB. In contrast, a severe bilateral decrease in WM in the MTLs was detected in patients with AD. CONCLUSIONS: VBM-DARTEL provided more accurate results, and it enabled the identification of more localized morphologic alterations than did conventional VBM. Analysis of WM preservation in DLB could help to differentiate this condition from AD.
• Estimation of Liver Function Using T1 Mapping on Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-enhanced Magnetic Resonance Imaging.

  Katsube T; Okada M; Kumano S; Hori M; Imaoka I; Ishii K; Kudo M; Kitagaki H; Murakami T

  Invest Radiol Lippincott Williams & Wilkins 46 277 - 283 2010/08 [Refereed]
  
• FDG PET/CT versus CT, MR Imaging, and Ga-67 Scintigraphy in the Posttherapy Evaluation of Malignant Lymphoma

  Masahiro Okada; Norihide Sato; Kazunari Ishii; Kaname Matsumura; Makoto Hosono; Takamichi Murakami

  RADIOGRAPHICS RADIOLOGICAL SOC NORTH AMERICA 30 (4) 939 - 960 0271-5333 2010/07 [Refereed]
   

  Malignant lymphoma is the most common form of hematologic cancer, yet because of advanced methods of assessment, the traditional histology-based classification of lymphoma is insufficient for understanding lymphoma imaging. Still, radiologists should be familiar with the imaging findings in lymphoma. Integrated positron emission tomography (PET) computed tomography (CT) allows improved diagnostic accuracy, and uptake of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) can help predict response during treatment. The sensitivity and specificity of FDG PET are superior to those of gallium 67 scintigraphy in all but indolent lymphoma. Both magnetic resonance (MR) imaging and CT allow excellent assessment of bone texture, but FDG PET is superior in demonstrating bone marrow metabolic activity. Thus, FDG PET is important in both the primary diagnosis and the evaluation of therapy in lymphoma. It may be difficult to determine whether residual abnormalities seen after the completion of chemotherapy radiation therapy represent residual tumor or fibrotic tissue, but PET/CT may allow more accurate diagnosis than MR imaging or CT, thereby helping identify patients who require more intensive treatment. Some diagnostic pitfalls are encountered at FDG PET. However, anatomic CT helps localize and define disease and avoid these potential pitfalls. (c) RSNA, 2010 . radiographics.rsna.org
• Late gadolinium enhancement on cardiac magnetic resonance imaging: is it associated with a higher incidence of nonsustained ventricular tachycardia in patients with idiopathic dilated cardiomyopathy?

  Atsushi K Kono; Kazunari Ishii; Hiroyuki Kumagai; Yasuyo Taniguchi; Teishi Kajiya; Kazuro Sugimura

  Japanese journal of radiology SPRINGER 28 (5) 355 - 61 1867-108X 2010/06 [Refereed]
   

  PURPOSE: Late gadolinium enhancement (LGE) during cardiac magnetic resonance imaging (MRI) can be seen in patients with myocardial fibrosis accompanied by myocardial infarction and cardiomyopathy. Some idiopathic dilated cardiomyopathy (DCM) patients have fibrosis in the myocardium and show LGE during cardiac MRI. The purpose of this study was to investigate the clinical significance of LGE in patients with DCM. MATERIALS AND METHODS: We recruited 32 DCM patients who had a left ventricular ejection fraction (LVEF) of <40% by echocardiography and performed cardiac MRI. LGE images were obtained 15 min after injection of Gd-DTPA (0.1 mmol/kg) using an inversion recovery gradient echo sequence. We compared LGE(+) and LGE(-) groups in terms of their nonsustained ventricular tachycardia (NSVT) properties. We also compared LGE and the frequency of an implantable cardioverter defibrillator (ICD) implantation. RESULTS: In total, 18 patients (56.3%) had LGE and a higher incidence of NSVT (P = 0.01). ICD implantation was more frequent in the LGE(+) group (P = 0.04). CONCLUSION: Because the LGE(+) patients showed a higher incidence of NSVT and ICD implantation, cardiac MRI could prove to be a useful tool in the management of DCM patients.
• Differential diagnosis of dementia with lewy bodies and alzheimer disease using combined MR imaging and brain perfusion single-photon emission tomography

  H. Goto; K. Ishii; T. Uemura; N. Miyamoto; T. Yoshikawa; K. Shimada; S. Ohkawa

  American Journal of Neuroradiology 31 (4) 720 - 725 0195-6108 2010/04 [Refereed]
   

  BACKGROUND AND PURPOSE: Diagnostic performance by MR imaging or by SPECT alone in discriminating DLB patients from AD patients has been estimated previously. However, the performance of a combination of MR imaging and SPECT has not yet been evaluated. Our aim was to evaluate the usefulness of combining MR imaging and SPECT to discriminate mild DLB from AD. MATERIALS AND METHODS: Nineteen patients with mild DLB and 19 age- and cognitive decline-matched patients with mild AD underwent both SPECT and MR imaging. Hippocampal, occipital, and striatal volume and SPECT count ratios were compared. Linear discriminant and ROC analyses were performed by using the parameters of striatal volume and the occipital SPECT ratio. RESULTS: The striatal volume ratio in the DLB group was significantly lower than that in the AD group. The occipital SPECT ratio in the DLB group was lower than that in the AD group. The mean area under the ROC curve from combined MR imaging and SPECT (AUC = 0.898) was higher than that from MR imaging (AUC = 0.679) or SPECT (AUC = 0.798) alone. CONCLUSIONS: By combining MR imaging and SPECT, we were able to distinguish patients with mild DLB from those with AD with a high level of accuracy. Our findings suggest that combining MR imaging and SPECT modalities is a useful and practical approach for diagnostically differentiating DLB from AD.
• Hypoperfusion of the motor cortex associated with parkinsonism in dementia with Lewy bodies.

  Ryuichi Takahashi; Kazunari Ishii; Kenichi Shimada; Shingo Ohkawa; Yo Nishimura

  Journal of the neurological sciences ELSEVIER SCIENCE BV 288 (1-2) 88 - 91 0022-510X 2010/01 [Refereed]
   

  OBJECTIVE: This study aimed to investigate the impact of parkinsonism on regional cerebral blood flow (rCBF) in dementia with Lewy bodies (DLB). METHOD: Forty-four probable DLB patients, comprising 13 patients without parkinsonism and 31 patients with parkinsonism, and 16 normal controls were selected for this study. We evaluated the rCBF in each group by means of N-isopropyl-p-[(123)I] iodoamphetamine (IMP) and single photon emission computed tomography (SPECT). The rCBF in the different groups was compared using voxel-by-voxel Statistical Parametrical Mapping (SPM). RESULT: Patients with DLB showed low rCBF in the frontal, temporal, and occipital cortex with relative sparing of the paracentral region. DLB patients with parkinsonism (DLB-P) had lower rCBF in the primary motor cortex (M1) and left supplementary motor area (SMA) than DLB patients without parkinsonism (DLB-nonP). DLB-nonP patients showed decreased rCBF in the left temporo-occipital region. CONCLUSION: This study suggests that two distinct clinical entities are involved in DLB. In addition, CBF changes in the M1 and SMA are seen in the early stages of Parkinson's disease. This result would help in diagnosing DLB in the context of Lewy body (LB) disease.
• Computer-assisted diagnostic system for neurodegenerative dementia using brain SPECT and 3D-SSP.

  Kazunari Ishii; Tomonori Kanda; Takafumi Uemura; Naokazu Miyamoto; Toshiki Yoshikawa; Kenichi Shimada; Shingo Ohkawa; Satoshi Minoshima

  European journal of nuclear medicine and molecular imaging SPRINGER 36 (5) 831 - 40 1619-7070 2009/05 [Refereed]
   

  PURPOSE: To develop a computer-assisted automated diagnostic system to distinguish among Alzheimer disease (AD), dementia with Lewy bodies (DLB), and other degenerative disorders in patients with mild dementia. METHODS: Single photon emission computed tomography (SPECT) images with injection of N-Isopropyl-p-[(123)I]iodoamphetamine (IMP) were obtained from patients with mild degenerative dementia. First, datasets from 20 patients mild AD, 15 patients with dementia with DLB, and 17 healthy controls were used to develop an automated diagnosing system based on three-dimensional stereotactic surface projections (3D-SSP). AD- and DLB-specific regional templates were created using 3D-SSP, and critical Z scores in the templates were established. Datasets from 50 AD patients, 8 DLB patients, and 10 patients with non-AD/DLB type degenerative dementia (5 with frontotemporal dementia and 5 with progressive supranuclear palsy) were then used to test the diagnostic accuracy of the optimized automated system in comparison to the diagnostic interpretation of conventional IMP-SPECT images. These comparisons were performed to differentiate AD and DLB from non-AD/DLB and to distinguish AD from DLB. A receiver operating characteristic (ROC) analysis was performed. RESULTS: The area under the ROC curve (Az) and the accuracy of the automated diagnosis system were 0.89 and 82%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the visual inspection were 0.84 and 77%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the combination of visual inspection and this system were 0.96 and 91%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 66%, respectively, for AD vs. DLB patients. CONCLUSION: The system developed in the present study achieved as good discrimination of AD, DLB, and other degenerative disorders in patients with mild dementia as the commonly performed visual inspection of conventional SPECT images. A combination of visual inspection and this system is helpful in the differential diagnosis of patients with mild dementia.
• Usefulness of a breath-holding acquisition method in PET/CT for pulmonary lesions

  Toshiaki Yamaguchi; Osamu Ueda; Hideyuki Hara; Hiroto Sakai; Tohru Kida; Kayo Suzuki; Shuji Adachi; Kazunari Ishii

  ANNALS OF NUCLEAR MEDICINE SPRINGER 23 (1) 65 - 71 0914-7187 2009/01 [Refereed]
   

  To evaluate the usefulness of a breath-holding (BH) (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET) technique for PET/computed tomography (CT) scanning of pulmonary lesions near the diaphragm, where image quality is influenced by respiratory motion.In a basic study, simulated breath-holding PET (sBH-PET) data were acquired by repeating image acquisition eight times with fixation of a phantom at 15 s/bed. Free-breathing PET (FB-PET) was simulated by acquiring data even as moving the phantom at 120 s/bed (sFB-PET). Images with total acquisition times of 15 s, 30 s, 45 s, 60 s, and 120 s were generated for sBHPET. Receiver-operating characteristic (ROC) analyses and determination of the statistical significance of differences between sFB-PET images and sBH-PET images were performed. A total of 22 pulmonary lesions in 21 patients (12 men and 9 women, mean age 61.3 +/- 10.6 years, 10 benign lesions in 9 patients and 12 malignant lesions in 12 patients) were examined by FB-PET and BH-PET). For evaluation of these two acquisition methods, displacement of the lesion between CT and PET was considered to be a translation, and the statistical significance of differences in maximum standardized uptake value (SUV(max)) of the lesion was assessed using the paired t test.In the basic study, sBH-PET images with acquisition times of 45 s, 60 s, and 120 s had significantly higher diagnostic accuracy than 120-s sFB-PET images (P < 0.05). In clinical cases, translation of the BH-PET images was significantly lower than that of the FB-PET images (benign: 5.29 +/- 4.02 mm vs. 11.79 +/- 8.27 mm, P = 0.005; malignant: 4.29 +/- 3.36 mm vs. 18.26 +/- 12.31 mm, P = 0.003). The SUV(max) of the lesions in the BH-PET images was significantly higher than that in the FB-PET images (benign: 2.40 +/- 0.86 vs. 2.20 +/- 0.85, P = 0.005; malignant: 4.84 +/- 2.16 vs. 3.75 +/- 2.11, P = 0.001).BH-PET provides images with better diagnostic accuracy, avoids image degradation owing to respiratory motion, and yields more accurate attenuation correction. This method is very useful for overcoming the problem of respiratory motion.
• Comparison of grey matter and metabolic reductions in frontotemporal dementia using FDG-PET and voxel-based morphometric MR studies.

  Tomonori Kanda; Kazunari Ishii; Takafumi Uemura; Naokazu Miyamoto; Toshiki Yoshikawa; Atsushi K Kono; Etsuro Mori

  European journal of nuclear medicine and molecular imaging SPRINGER 35 (12) 2227 - 34 1619-7070 2008/12 [Refereed]
   

  PURPOSE: The aim of this study was to investigate the regional differences between the morphologic and functional changes in the same patients with frontotemporal dementia (FTD) using statistical parametric mapping and voxel-based morphometry (VBM). METHODS: Thirteen FTD patients (mean age, 64.9 years old; mean MMSE score, 17.7), 20 sex-matched Alzheimer's disease (AD) patients (mean age, 65.0 years old; mean MMSE score, 17.5), and 20 normal volunteers (mean age, 65.2 years old; mean MMSE score, 29.0) underwent both [(18)F]FDG positron emission tomography and three-dimensional spoiled gradient echo MRI. Statistical parametric mapping was used to conduct a VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of glucose metabolic data. RESULTS: FTD patients showed decreased grey matter volume and decreased glucose metabolism in the frontal lobe and anterior temporal lobe. In addition, there was a clear asymmetry in grey matter volume in FTD patients by the VBM analysis while the glucose metabolic data showed little asymmetry. In AD patients, glucose metabolic reduction occurred in the bilateral posterior cingulate gyri and parietal lobules while grey matter density decreased the least in the same patients. CONCLUSION: In FTD, metabolic and morphologic changes occur in the bilateral frontal lobe and temporal lobe with a limited asymmetry whereas there was considerable discordance in the AD group.
• Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus.

  Kazunari Ishii; Tomonori Kanda; Aya Harada; Naokazu Miyamoto; Tetsuro Kawaguchi; Kenichi Shimada; Shingo Ohkawa; Takafumi Uemura; Toshiki Yoshikawa; Etsuro Mori

  European radiology SPRINGER 18 (11) 2678 - 83 0938-7994 2008/11 [Refereed]
   

  The utility of measuring the corpus callosal angle (CA) for the diagnosis of idiopathic normal pressure hydrocephalus (INPH) was investigated. Three-dimensional magnetic resonance imaging (MRI) was performed in 34 INPH patients, 34 Alzheimer's disease (AD) patients, and 34 normal control (NC) subjects. Measurement of the CA on the coronal MR images of the posterior commissure perpendicular to the anteroposterior commissure plane was performed for all subjects. The CA of the INPH group (mean +/- SD, 66 +/- 14 degrees) was significantly smaller than those of the AD (104 +/- 15 degrees) and NC (112 +/- 11 degrees) groups. When using the threshold of the mean - 2SD value of the NC group (= 90 degrees), an accuracy of 93%, sensitivity of 97%, and specificity of 88% were observed for discrimination of INPH from AD patients. Measuring the CA helps in differentiating INPH patients from AD and normally aged subjects.
• Global cerebral hypoperfusion in a patient with transient global amnesia

  Yumiko Yamane; Kazunari Ishii; Kotaro Shimizu; Keitaro Sofue; Toshiki Yoshikawa; Naokazu Miyamoto; Shingo Ohkawa

  JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LIPPINCOTT WILLIAMS & WILKINS 32 (3) 415 - 417 0363-8715 2008/05 [Refereed]
   

  We report a 64-year-old male patient with pure transient global amnesia (TGA) who exhibited global cerebral hypoperfusion during an amnesia attack. Initial single photon emission computed tomography (SPECT) performed 3 hours after the onset of the amnesic attack revealed diffuse hypoperfusion in the cerebrum, whereas a second SPECT study, I month later, revealed improvement of cerebral blood flow. This case suggests that SPECT study is useful in revealing the pathophysiological mechanism of TGA and that TGA attacks are associated with global cerebral blood flow change.
• Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus.

  Kazunari Ishii; Tetsuro Kawaguchi; Kenichi Shimada; Shingo Ohkawa; Naokazu Miyamoto; Tomonori Kanda; Takafumi Uemura; Toshiki Yoshikawa; Etsuro Mori

  Dementia and geriatric cognitive disorders KARGER 25 (4) 329 - 35 1420-8008 2008 [Refereed]
   

  AIMS: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. METHOD: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. RESULTS: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. CONCLUSION: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.
• Fully automatic differential diagnosis system for dementia with Lewy bodies and Alzheimer's disease using FDG-PET and 3D-SSP.

  Atsushi K Kono; Kazunari Ishii; Keitaro Sofue; Naokazu Miyamoto; Setsu Sakamoto; Etsuro Mori

  European journal of nuclear medicine and molecular imaging SPRINGER 34 (9) 1490 - 7 1619-7070 2007/09 [Refereed]
   

  PURPOSE: To evaluate a fully automatic computer-assisted diagnostic system for mild dementia with Lewy bodies (DLB), permitting distinction from mild Alzheimer's disease (AD). METHODS: Using 18F-fluorodeoxyglucose and positron emission tomography (FDG-PET), glucose metabolic images were obtained from mild DLB and mild AD patients. Two groups consisting of 16 mild DLB patients and 21 mild AD patients were recruited for diagnostic evaluation between mild DLB and mild AD. The mean age+/-SD of the mild DLB group and the mild AD group was 74.3+/-4.9 and 71.7+/-2.1 years, respectively, and the mean scores of the MMSE for the mild DLB and the mild AD group were 21.7+/-1.9 and 23.1+/-2.1, respectively. A receiver operating characteristic (ROC) analysis was performed to compare the diagnostic performance, in terms of discrimination between DLB and AD, of conventional axial FDG-PET images inspected visually by experts and beginners with that of our fully automatic diagnosis system using the statistical brain mapping method and Z scores obtained with the DLB template. RESULTS: The diagnostic performance of the automatic system was comparable to that of visual inspection by experts. The area under the ROC curve for the automatic diagnosis system was 0.77. The mean area under the ROC curve for visual inspection by experts and beginners was 0.76 and 0.65, respectively. CONCLUSION: The fully automatic differential diagnosis system for distinction between mild DLB and AD showed a similar diagnostic accuracy to visual inspection by experts. It would be a useful diagnostic tool to distinguish mild DLB from mild AD in clinical practice.
• Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei

  Yoshiyuki Nishio; Kazunari Ishii; Hiroaki Kazui; Yoshiyuki Hosokai; Etsuro Mori

  JOURNAL OF THE NEUROLOGICAL SCIENCES ELSEVIER SCIENCE BV 260 (1-2) 271 - 274 0022-510X 2007/09 [Refereed]
   

  A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainstern dopaminergic nuclei and hypoperfusion in the frontal-subcortical circuit components. We suggest that the patient's cognitive and behavioral disturbances were associated with disruption of ascending dopaminergic projections to the frontal-subcortical circuits. (c) 2007 Elsevier B.V. All rights reserved.
• Comparison of regional brain volume and glucose metabolism between patients with mild dementia with lewy bodies and those with mild Alzheimer's disease.

  Kazunari Ishii; Tsutomu Soma; Atsushi K Kono; Keitaro Sofue; Naokazu Miyamoto; Toshiki Yoshikawa; Etsuro Mori; Kenya Murase

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine SOC NUCLEAR MEDICINE INC 48 (5) 704 - 11 0161-5505 2007/05 [Refereed]
   

  UNLABELLED: The aim of this study was to investigate regional differences between morphologic and functional changes in patients with mild dementia with Lewy bodies (DLB) compared with those with Alzheimer's disease (AD). METHODS: Twenty patients with very mild DLB (mean age, 74.5 y; mean Mini-Mental State Examination [MMSE] score, 24.0), 20 patients with very mild AD (mean age, 74.1 y; mean MMSE score, 24.0), and 20 age- and sex-matched healthy volunteers (normal controls [NC]) underwent both (18)F-FDG PET and 3-dimensional spoiled gradient echo MRI. Fully automatic volumetry of the MRI data was used to obtain whole brain, hippocampal, occipital, and striatal volumes, which were compared with the results of a similar analysis of glucose metabolic data. RESULTS: In DLB patients, volumetric data indicated a significant volume decrease in the striatum, whereas (18)F-FDG PET showed significant glucose metabolic reductions in the temporal, parietal, and frontal areas--including in the occipital lobe--compared with those in the NC group. In contrast, in AD patients, both the hippocampal volume and glucose metabolism were significantly decreased, whereas the occipital volume and metabolism were preserved. CONCLUSION: Comparison of very mild DLB and AD revealed different morphologic and metabolic changes occurring in the medial temporal lobes and the occipital lobe, demonstrating characteristic pathophysiologic differences between these 2 diseases.
• Probabilistic cortical surface map of the middle cerebral artery territory for single-photon emission computed tomography studies.

  Kohkichi Hosoda; Kazunari Ishii; Satoshi Minoshima; Eiji Kohmura

  Journal of neurosurgery AMER ASSOC NEUROLOGICAL SURGEONS 106 (1) 119 - 27 0022-3085 2007/01 [Refereed]
   

  OBJECT: The middle cerebral artery (MCA) is the intracranial vessel most frequently affected by cerebrovascular diseases. A more accurate knowledge of the topography of this vessel may have an impact on treatment strategies for ischemic cerebrovascular diseases. The aim of this study was to construct a topographic map of the MCA territory for single-photon emission computed tomography (SPECT) using statistical brain mapping. METHODS: The margin of the perfusion deficit associated with infarction due to arterial occlusion, as seen on SPECT imaging, is presumed to approximate the borders of the territory of the artery. Basing the study on this hypothesis, SPECT images obtained in 12 patients with large MCA infarctions due to angiographically confirmed MCA trunk occlusion were selected, anatomically standardized, and compared with SPECT images obtained in healthy volunteers to construct probabilistic cortical surface maps of the MCA territory. Crossed cerebellar diaschisis was used as a primary cutoff marker for creation of the map. This MCA map (Method C) was compared with the conventional region of interest (ROI) method (Method A) and previously reported predefined cortical templates (Method B) for preliminary clinical application. The probabilistic cortical surface map of the MCA territory showed that regions with the highest ratio of MCA territory included the transverse temporal gyrus (100%), supramarginal gyrus (100%), and inferior parietal lobule (91-92%). For preliminarily clinical application, this map (Method C) was compared with the conventional ROI method (Method A) in predicting hyperperfusion after carotid endarterectomy by performing a receiver operating characteristic (ROC) analysis, which demonstrated the statistically significant superiority of the MCA map (area under the ROC curve [Az] = 0.91) to the ROI method (Az = 0.75; p = 0.025). The ROC analysis also demonstrated a diagnostic value of the MCA map (Az = 0.95) that equaled predefined cortical templates (Method B) (Az = 0.93). CONCLUSIONS: The probabilistic cortical surface map of the MCA territory used for SPECT, which was created using statistical brain mapping techniques, would be useful for an objective assessment of the cerebral perfusion status of patients with cerebrovascular diseases.
• Cerebral perfusion pattern of idiopathic normal pressure hydrocephalus studied by SPECT and statistical brain mapping.

  Hiroki Sasaki; Kazunari Ishii; Atsushi K Kono; Naokazu Miyamoto; Tetsuya Fukuda; Kenichi Shimada; Shingo Ohkawa; Tetsuro Kawaguchi; Etsuro Mori

  Annals of nuclear medicine JAPANESE SOCIETY NUCLEAR MEDICINE 21 (1) 39 - 45 0914-7187 2007/01 [Refereed]
   

  OBJECTIVES: To investigate the specific pattern of cerebral blood flow (CBF) in subjects with idiopathic normal pressure hydrocephalus (iNPH) using voxel-based analysis. METHODS: N-isopropyl-p-[123I]iodoamphetamine (IMP) single photon emission computed tomography (SPECT) images were performed in 30 iNPH patients, who met probable iNPH criteria, 30 Alzheimer disease (AD) patients and 15 normal control (NC) subjects. Inter-group comparisons between iNPH patients and NC subjects and between AD patients and NC subjects were performed using three-dimensional stereotactic surface projection (3D-SSP) analysis. Individual 3D-SSP images of the iNPH patients were assessed by visual inspection. RESULTS: On the Z-score maps, areas of relative hypoperfusion were recognized around the corpus callosum in all 30 iNPH patients, as well as in the Sylvian fissure regions in 19 of 30 iNPH patients which included artifacts by dilated ventricles and the Sylvian fissures. Ten frontal dominant, eight parietotemporal dominant, and 12 diffuse hypoperfusion types were demonstrated. Inter-group comparison between iNPH and NC subjects showed relative hypoperfusion in the frontal and parietotemporal areas and severe hypoperfusion around the corpus callosum and Sylvian fissure regions, while parietotemporal and posterior cingulate CBF reduction was demonstrated between the AD and NC groups. CONCLUSION: Voxel-based analysis showed a characteristic pattern of regional CBF reduction with frontal dominant or diffuse cerebral hypoperfusion accompanying severe hypoperfusion around the corpus callosum and Sylvian fissures with artifacts.
• Cerebral perfusion pattern of idiopathic normal pressure hydrocephalus studied by SPECT and statistical brain mapping

  Hiroki Sasaki; Kazunari Ishii; Atsushi K. Kono; Naokazu Miyamoto; Tetsuya Fukuda; Kenichi Shimada; Shingo Ohkawa; Tetsuro Kawaguchi; Etsuro Mori

  ANNALS OF NUCLEAR MEDICINE JAPANESE SOCIETY NUCLEAR MEDICINE 21 (1) 39 - 45 0914-7187 2007/01 [Refereed]
   

  Objectives: To investigate the specific pattern of cerebral blood flow (CBF) in subjects with idiopathic normal pressure hydrocephalus (iNPH) using voxel-based analysis. Methods: N-isopropyl-p-[I-123]iodoamphetamine (IMP) single photon emission computed tomography (SPECT) images were performed in 30 iNPH patients, who met probable iNPH criteria, 30 Alzheimer disease (AD) patients and 15 normal control (NC) subjects. Inter-group comparisons between iNPH patients and NC subjects and between AD patients and NC subjects were performed using three-dimensional stereotactic surface projection (3D-SSP) analysis. Individual 3D-SSP images of the iNPH patients were assessed by visual inspection. Results: On the Z-score maps, areas of relative hypoperfusion were recognized around the corpus callosum in all 30 iNPH patients, as well as in the Sylvian fissure regions in 19 of 30 iNPH patients which included artifacts by dilated ventricles and the Sylvian fissures. Ten frontal dominant, eight parietotemporal dominant, and 12 diffuse hypoperfusion types were demonstrated. Inter-group comparison between iNPH and NC subjects showed relative hypoperfusion in the frontal and parietotemporal areas and severe hypoperfusion around the corpus callosum and Sylvian fissure regions, while parietotemporal and posterior cingulate CBF reduction was demonstrated between the AD and NC groups. Conclusion: Voxel-based analysis showed a characteristic pattern of regional CBF reduction with frontal dominant or diffuse cerebral hypoperfusion accompanying severe hypoperfusion around the corpus callosum and Sylvian fissures with artifacts.
• Usefulness of intravascular ultrasonography for treatment of a ruptured vertebral dissecting aneurysm.

  Atsushi K Kono; Tetsuya Fukuda; Yuji Shibata; Masaki Iwakura; Hideki Komatsu; Hiroki Sasaki; Tetsuro Kawaguchi; Kazunari Ishii

  Radiation medicine 8 24 (8) 577 - 82 0288-2043 2006/10 [Refereed]
   

  We report successful stent implantation and secondary coil embolization in a wide-necked dissecting aneurysm in the vertebral artery. Intravascular ultrasonography (IVUS) showed the thrombosed pseudolumen clearly and enabled precise determination of the appropriate stent size. After stent implantation, Guglielmi detachable coil embolization was performed. Further experience is necessary to refine the technique, but IVUS may be useful to improve the safety of stent-assisted embolization.
• Comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer's disease.

  Takashi Kawachi; Kazunari Ishii; Setsu Sakamoto; Masahiro Sasaki; Tetsuya Mori; Fumio Yamashita; Hiroshi Matsuda; Etsuro Mori

  European journal of nuclear medicine and molecular imaging SPRINGER 33 (7) 801 - 9 1619-7070 2006/07 [Refereed]
   

  PURPOSE: The aim of this study was to compare the diagnostic performance of( 18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM) on magnetic resonance imaging (MRI) in the same group of patients with very mild Alzheimer's disease (AD). METHODS: Thirty patients with very mild AD (age 67.0+/-5.8 years; MMSE score 25.5+/-1.2, range 24-28), 32 patients with mild AD (age 67.0+/-4.5 years, MMSE score 22.1+/-0.8, range 21-23) and 60 age- and sex-matched normal volunteers underwent both FDG-PET and three-dimensional spoiled gradient echo MRI. Statistical parametric mapping was used to conduct voxel by voxel analysis and Z score mapping. First, the region of interest (ROI) maps of significant reductions in glucose metabolism and grey matter density in the mild AD patients were defined. Secondly, analysis of receiver operating characteristic (ROC) curves for Z scores in the ROI maps discriminating very mild AD patients and normal controls was performed. RESULTS: In mild AD patients, FDG-PET indicated significant reductions in glucose metabolism in the bilateral posterior cingulate gyri and the right parietotemporal area, while VBM analysis showed a significant decrease in grey matter volume density in the bilateral amygdala/hippocampus complex, compared with the normal control group. ROC analysis showed that in very mild AD patients the accuracy of FDG-PET diagnosis was 89% and that of VBM-MRI diagnosis was 83%. The accuracy of the combination of FDG-PET and VBM-MRI diagnosis was 94%. CONCLUSION: In very mild AD, both FDG-PET and VBM-MRI had high accuracy for diagnosis, but FDG-PET showed slightly higher accuracy than VBM-MRI. Combination of the two techniques will yield a higher diagnostic accuracy in very mild AD by making full use of functional and morphological images.
• Automatic volumetric measurement of segmented brain structures on magnetic resonance imaging.

  Kazunari Ishii; Tsutomu Soma; Atsushi K Kono; Hiroki Sasaki; Naokazu Miyamoto; Tetsuya Fukuda; Kenya Murase

  Radiation medicine 6 24 (6) 422 - 30 0288-2043 2006/07 [Refereed]
   

  PURPOSE: The purpose of this study was to produce a fully automatic volumetric segmented brain image system (AVSIS) and to evaluate its utility for measuring hippocampal volumes and total intracranial volume (TIV). MATERIALS AND METHODS: We developed a combination technique comprising an anatomical standardization technique to measure TIV, whole brain volume (WBV), and hippocampal volume obtained by magnetic resonance (MR) imaging. Altogether, 15 healthy volunteers and 15 patients with Alzheimer's disease (AD) underwent three-dimensional spoiled gradient echo (3D-SPGR) imaging. Three measurements were performed by manual volumetry as the gold standard, a previous semiautomatic method, and our new method, AVSIS. RESULTS: WBV and hippocampal volume in the AD group were significantly smaller than those in the healthy volunteer group measured by the semiautomatic method, manual method, and AVSIS. Each volume measured by AVSIS or semiautomatic method correlated with that measured by the manual method. The correlation coefficients between TIVs, WBVs, or hippocampal volumes measured by AVSIS and the manual method were 0.910, 0.902, and 0.918, respectively; the correlation coefficients between TIVs, or WBVs, measured by the previous semiautomatic method and the manual method were 0.875, and 0.886, respectively. CONCLUSION: We developed a system for a fully automatic measurement of segmented brain structures and obtained good results.
• Early disappearance of calcification in posterior paraspinal muscles in a patient with rhabdomyolysis associated with neuroleptic malignant syndrome.

  Hiroki Sasaki; Kazunari Ishii; Atsushi K Kono; Naokazu Miyamoto; Tetsuya Fukuda; Junko Kanata; Yasushi Kita

  Radiation medicine 6 24 (6) 463 - 6 0288-2043 2006/07 [Refereed]
   

  We report computed tomography (CT) findings that demonstrated early disappearance of ectopic calcification in the bilateral posterior paraspinal muscles in a patient with rhabdomyolysis. A 37-year-old man with acute renal failure due to rhabdomyolysis caused by neuroleptic malignant syndrome underwent studies with CT and bone scintigraphy. First, bone scintigraphy showed high radiotracer uptake in bilateral posterior paraspinal muscles; then CT demonstrated ectopic calcification in those muscles. After 2.5 months, CT showed that the calcification had completely disappeared. Bone scintigraphy anticipated calcification, and CT demonstrated a unique course of early disappearance of the calcification.
• Fully automatic diagnostic system for early- and late-onset mild Alzheimer's disease using FDG PET and 3D-SSP.

  Kazunari Ishii; Atsushi K Kono; Hiroki Sasaki; Naokazu Miyamoto; Tetsuya Fukuda; Setsu Sakamoto; Etsuro Mori

  European journal of nuclear medicine and molecular imaging SPRINGER 33 (5) 575 - 83 1619-7070 2006/05 [Refereed]
   

  PURPOSE: The purpose of this study was to design a fully automatic computer-assisted diagnostic system for early- and late-onset mild Alzheimer's disease (AD). METHODS: Glucose metabolic images were obtained from mild AD patients and normal controls using positron emission tomography (PET) and( 18)F-fluorodeoxyglucose (FDG). Two groups of 20 mild AD patients with different ages of onset were examined. A fully automatic diagnostic system using the statistical brain mapping method was established from the early-onset (EO) and late-onset (LO) groups, with mean ages of 59.1 and 70.9 years and mean MMSE scores of 23.3 and 22.8, respectively. Aged-matched normal subjects were used as controls. We compared the diagnostic performance of visual inspection of conventional axial FDG PET images by experts and beginners with that of our fully automatic diagnostic system in another 15 EO and 15 LO AD patients (mean age 58.4 and 71.7, mean MMSE 23.6 and 23.1, respectively) and 30 age-matched normal controls. A receiver operating characteristic (ROC) analysis was performed to compare data. RESULTS: The diagnostic performance of the automatic diagnostic system was comparable with that of visual inspection by experts. The area under the ROC curve for the automatic diagnostic system was 0.967 for EO AD patients and 0.878 for LO AD patients. The mean area under the ROC curve for visual inspection by experts was 0.863 and 0.881 for the EO and LO AD patients, respectively. The mean area under the ROC curve for visual inspection by beginners was 0.828 and 0.717, respectively. CONCLUSION: The fully automatic diagnostic system for EO and LO AD was able to perform at a similar diagnostic level to visual inspection of conventional axial images by experts.
• Necessity of a uniform start for scanning after FDG injection in brain PET study

  K Ishii; Y Higashi; M Tabata; M Miyaishi; T Mizutani; M Sasaki

  ANNALS OF NUCLEAR MEDICINE JAPANESE SOCIETY NUCLEAR MEDICINE 20 (4) 329 - 331 0914-7187 2006/05 [Refereed]
   

  The authors' goal was to show the importance of starting scanning at a uniform time after F-18 fluorodeoxyglucose injection in positron emission tomography (PET) brain study. Method: Fifteen healthy normal subjects underwent FDG-PET to obtain glucose metabolic images starting 60 min and 70 min after FDG injection, respectively. The two sets of images were compared in a voxel-by-voxel analysis. Results: In the bilateral posterior cingulate gyrus, parietal and frontal association cortices, the FDG uptakes were larger on the 70 min scan images than on the 60 min scan images; the 60 min scans resembled Alzheimer's metabolic reduction area. Similarly the FDG uptakes were larger in the pons and vermis on the 60 min scan image than on the 70 min scan image. Conclusions: Regional FDG uptake is different depending on the time scanning starts after FDG injection, even with a 10 minute difference in start time and different scanning time may lead to misdiagnosis. It is important to standardize the start time of FDG PET after FDG injection in brain PET.
• Necessity of a uniform start for scanning after FDG injection in brain PET study.

  Kazunari Ishii; Yasuto Higashi; Masako Tabata; Masahiro Miyaishi; Takashi Mizutani; Masahiro Sasaki

  Annals of nuclear medicine JAPANESE SOCIETY NUCLEAR MEDICINE 20 (4) 329 - 31 0914-7187 2006/05 [Refereed]
   

  UNLABELLED: The authors' goal was to show the importance of starting scanning at a uniform time after F-18 fluorodeoxyglucose injection in positron emission tomography (PET) brain study. METHOD: Fifteen healthy normal subjects underwent FDG-PET to obtain glucose metabolic images starting 60 min and 70 min after FDG injection, respectively. The two sets of images were compared in a voxel-by-voxel analysis. RESULTS: In the bilateral posterior cingulate gyrus, parietal and frontal association cortices, the FDG uptakes were larger on the 70 min scan images than on the 60 min scan images; the 60 min scans resembled Alzheimer's metabolic reduction area. Similarly the FDG uptakes were larger in the pons and vermis on the 60 min scan image than on the 70 min scan image. CONCLUSIONS: Regional FDG uptake is different depending on the time scanning starts after FDG injection, even with a 10 minute difference in start time and different scanning time may lead to misdiagnosis. It is important to standardize the start time of FDG PET after FDG injection in brain PET.
• The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1

  K Ishii; H Hisaeda; XF Duan; T Imai; T Sakai; HJ Fehling; S Murata; T Chiba; K Tanaka; S Hamano; M Sano; A Yano; K Himeno

  MICROBES AND INFECTION ELSEVIER SCIENCE BV 8 (4) 1045 - 1053 1286-4579 2006/04 [Refereed]
   

  The ubiquitin-proteasome system (UPS) plays an indispensable role in inducing MHC class I-restricted CD8(+) T cells and was exploited in the development of a DNA vaccine against the intracellular protozoan Toxoplasma gondii by constructing a chimeric DNA encoding a fusion protein between murine ubiquitin and the toxoplasma antigen SAG1. The SAG1 peptide was promptly degraded in antigen-presenting cells (APCs) transfected with the chimeric DNA. Degradation, however, was hampered by incubating the APCs with the proteasome inhibitor epoxomicin. Mice vaccinated with the DNA acquired potent protective immunity mediated by MHC class I-restricted CD8(+) T cells against infection by the highly virulent Toxoplasma. The accelerated degradation and induction of immunity were dependent on the UPS since mice lacking an immuno-subunit of 20S proteasome, LMP7, lost these functions, although they were independent of the proteasome regulator PA28 alpha/beta complex. (c) 2005 Elsevier SAS. All rights reserved.
• Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: a case-control study.

  Wenxiang Quan; Minoru Yasuda; Mamoru Hashimoto; Yasuji Yamamoto; Kazunari Ishii; Hiroaki Kazui; Etsuro Mori; Tatsuya Kakigi; Kiyoshi Maeda

  Journal of the neurological sciences ELSEVIER SCIENCE BV 240 (1-2) 71 - 5 0022-510X 2006/01 [Refereed]
   

  OBJECTIVE: presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of presenilin-2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the presenilin-2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study. METHODS: We examined 230 patients with Alzheimer's disease, along with an equal number of age- and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis. RESULTS: The presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer's disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer's disease (0.20) and elderly controls (0.20). We found no evidence for an association between the presenilin-2 polymorphism and the apolipoprotein E epsilon4 allele. CONCLUSIONS: Our results fail to support an association of presenilin-2 gene polymorphism with Alzheimer's disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.
• PET is better than perfusion SPECT for early diagnosis of Alzheimer's disease -- for.

  Kazunari Ishii; Satoshi Minoshima

  European journal of nuclear medicine and molecular imaging SPRINGER 32 (12) 1463 - 5 1619-7070 2005/12 [Refereed]
  
• Comparison of gray matter and metabolic reduction in mild Alzheimer's disease using FDG-PET and voxel-based morphometric MR studies.

  Kazunari Ishii; Hiroki Sasaki; Atsushi K Kono; Naokazu Miyamoto; Tetsuya Fukuda; Etsuro Mori

  European journal of nuclear medicine and molecular imaging SPRINGER 32 (8) 959 - 63 1619-7070 2005/08 [Refereed]
   

  PURPOSE: The aim of this study was to investigate regional differences between morphologic and functional changes in the same patients with mild Alzheimer's disease (AD) using statistical parametric mapping (SPM) and voxel-based morphometry (VBM). METHODS: Thirty patients with very mild AD (mean age 66.8 years, mean MMSE score 24.0) and 30 age- and sex-matched normal volunteers underwent both( 18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and three-dimensional spoiled gradient echo (SPGR) magnetic resonance imaging (MRI). Statistical parametric mapping was used to conduct VBM analysis of the morphological data, which were compared voxel by voxel with the results of a similar analysis of the glucose metabolic data. RESULTS: In AD patients, VBM data indicated a significant gray matter volume density decrease in bilateral amygdala/hippocampus complex (p < 0.05, corrected), while FDG-PET analysis showed significant glucose metabolic reductions in the posterior cingulate gyri and the right parietal lobule, compared with those in the normal control group. CONCLUSION: In very mild AD, morphological change occurs in the medial temporal lobes, while in contrast, metabolic changes occur in the posterior cingulate gyri and parietal lobule.
• WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation

  A Takeda; S Hamano; H Shiraishi; T Yoshimura; H Ogata; K Ishii; T Ishibashi; A Yoshimura; H Yoshida

  INTERNATIONAL IMMUNOLOGY OXFORD UNIV PRESS 17 (7) 889 - 897 0953-8178 2005/07 [Refereed]
   

  WSX-1 is a component of the IL-27R. Analyses of WSX-1 knockout (WSX-1(-/-)) mice have shown that IL-27/WSX-1 signaling is essential for the proper development of T(h)1 responses and that WSX-1 can suppress cellular activation and pro-inflammatory cytokine production. We have generated transgenic mouse lines over-expressing the WSX-1 gene under the control of the T cell-specific CD2 promoter (WSX-1 Tg mice). Unexpectedly, like activated CD4(+) T cells from WSX-1(-/-) mice, activated CD4(+) T cells from WSX-1 Tg mice showed increased proliferation, augmented IL-2 production and up-regulated surface expression of activation markers. IL-27-mediated tyrosine phosphorylation of STAT1 was also enhanced in WSX-1 Tg CD4(+) T cells, but STAT3 activation was normal. Exogenous IL-27 supported the proliferation of wild-type CD4(+) T cells but suppressed that of WSX-1 Tg cells. WSX-1 over-expression increased IFN-gamma production in T(h)1-polarized CD4(+) T cells, but also promoted T(h)2 cytokine production under T(h)1-polarizing conditions. Importantly, WSX-1 over-expression failed to suppress T(h)2 cytokine production under T(h)2-polarizing conditions. Cytokine hyperproduction was also observed in vivo in WSX-1 Tg mice injected with Con A. Our data suggest that WSX-1 plays a pivotal role in regulating T cell responsiveness to TCR stimulation and that the correct balance of STAT1/STAT3 activation downstream of IL-27R engagement is crucial for the physiological function of IL-27.
• Comparison of conventional region of interest and statistical mapping method in brain single-photon emission computed tomography for prediction of hyperperfusion after carotid endarterectomy

  K Hosoda; T Kawaguchi; K Ishii; S Minoshima; E Kohmura

  NEUROSURGERY LIPPINCOTT WILLIAMS & WILKINS 57 (1) 32 - 40 0148-396X 2005/07 [Refereed]
   

  OBJECTIVE: Hyperperfusion after carotid endarterectomy (CEA) has been proposed as the main mechanism of intracerebral hemorrhage, which is a disastrous complication. The aim of this study was to compare the predictive value of cerebral blood flow (CBF) abnormalities for hyperperfusion after CEA with the conventional region of interest (ROI) analysis and statistical brain mapping analysis. METHODS: For 46 patients with unilateral carotid stenosis of 70% or more, CBF and cerebral vasoreactivity were investigated with resting and acetazolamide-challenge single-photon emission computed tomography before CEA and 1 day after CEA. Three-dimensional sterectactic surface projection (3-D-SSP) analysis of CBF changes was performed by automatic quantification with a predefined template. RESULTS: Logistic regression analysis demonstrated CBF reduction (z-score) to be the only significant variable for postoperative hyperperfusion on 3-D-SSP with thalamic normalization but no significant variable with the ROI method. Receiver operating characteristic (ROC) analysis demonstrated significant improvement in the predictive value of CBF reduction (z-score) on 3-D-SSP (area under the ROC curve = 0.93) in comparison with the ROI method (area under the ROC curve = 0.78) (P = 0.049). According to the optimal cutoff values provided by ROC analysis, patients were categorized into two groups: Type I (CBF decrease < 20%, n = 23) and Type 11 (CBF decrease >= 20%, n = 23) on ROI analysis and Type A (z-score <= 2, In = 40) and Type B (z-score > 2, n = 6) on 3-D-SSP. There was a significant difference in incidence of hyperperfusion between Type A (1 of 40) and Type B (5 of 6) on 3-D-SSP (P = 0.00003) but not between Type I (I of 23) and Type 11 (5 of 23) on ROI analysis. Cerebral vasoreactivity did not show significant value in the prediction of hyperperfusion with either the ROI or the 3-D-SSP method. CONCLUSION: Objective assessment of CBF status, especially baseline CBF reduction (z-score), with automatic quantification by 3-D-SSP with normalization had a higher diagnostic value than conventional ROI analysis to identify patients at risk for hyperperfusion after CEA.
• Comparison of conventional region of interest and statistical mapping method in brain single-photon emission computed tomography for prediction of hyperperfusion after carotid endarterectomy.

  Kohkichi Hosoda; Tetsuro Kawaguchi; Kazunari Ishii; Satoshi Minoshima; Eiji Kohmura

  Neurosurgery LIPPINCOTT WILLIAMS & WILKINS 57 (1) 32 - 41 0148-396X 2005/07 [Refereed]
   

  OBJECTIVE: Hyperperfusion after carotid endarterectomy (CEA) has been proposed as the main mechanism of intracerebral hemorrhage, which is a disastrous complication. The aim of this study was to compare the predictive value of cerebral blood flow (CBF) abnormalities for hyperperfusion after CEA with the conventional region of interest (ROI) analysis and statistical brain mapping analysis. METHODS: For 46 patients with unilateral carotid stenosis of 70% or more, CBF and cerebral vasoreactivity were investigated with resting and acetazolamide-challenge single-photon emission computed tomography before CEA and 1 day after CEA. Three-dimensional stereotactic surface projection (3-D-SSP) analysis of CBF changes was performed by automatic quantification with a predefined template. RESULTS: Logistic regression analysis demonstrated CBF reduction (z-score) to be the only significant variable for postoperative hyperperfusion on 3-D-SSP with thalamic normalization but no significant variable with the ROI method. Receiver operating characteristic (ROC) analysis demonstrated significant improvement in the predictive value of CBF reduction (z-score) on 3-D-SSP (area under the ROC curve = 0.93) in comparison with the ROI method (area under the ROC curve = 0.78) (P = 0.049). According to the optimal cutoff values provided by ROC analysis, patients were categorized into two groups: Type I (CBF decrease < 20%, n = 23) and Type II (CBF decrease > or = 20%, n = 23) on ROI analysis and Type A (z-score < or = 2, n = 40) and Type B (z-score > 2, n = 6) on 3-D-SSP. There was a significant difference in incidence of hyperperfusion between Type A (1 of 40) and Type B (5 of 6) on 3-D-SSP (P = 0.00003) but not between Type I (1 of 23) and Type II (5 of 23) on ROI analysis. Cerebral vasoreactivity did not show significant value in the prediction of hyperperfusion with either the ROI or the 3-D-SSP method. CONCLUSION: Objective assessment of CBF status, especially baseline CBF reduction (z-score), with automatic quantification by 3-D-SSP with normalization had a higher diagnostic value than conventional ROI analysis to identify patients at risk for hyperperfusion after CEA.
• Detectability of hypometabolic regions in mild Alzheimer disease: function of time after the injection of 2-[fluorine 18]-fluoro-2-deoxy-D-glucose.

  Setsu Sakamoto; Kazunari Ishii; Kayo Hosaka; Tetsuya Mori; Masahiro Sasaki; Etsuro Mori

  AJNR. American journal of neuroradiology AMER SOC NEURORADIOLOGY 26 (4) 843 - 7 0195-6108 2005/04 [Refereed]
   

  BACKGROUND AND PURPOSE: 2-[Fluorine 18]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) has played an important role in detecting hypometabolic regions in the brains of patients with dementia. To our knowledge, the optimal imaging time for dementia has not been investigated. The aim of this study was to evaluate the sensitivity of the early scanning (ES) compared with late scanning (LS) for demonstrating decreased regional glucose metabolism in patients with Alzheimer disease (AD). METHODS: Twenty patients with mild AD (mean age +/- standard deviation, 64.8 +/- 5.2 years) and 20 age- and sex-matched healthy volunteers (age, 65.9 +/- 4.5 years) were underwent FDG PET. Their cerebral glucose metabolic images were obtained on ES at 30-42 minutes and LS at 60-72 minutes after the administration of FDG 185-346 MBq. We compared regional cerebral metabolic images in a voxel-by-voxel analysis with statistical parametric mapping between patients with AD and control subjects and evaluated the difference in the hypometabolic regions between the two scans. RESULTS: In the AD-to-healthy comparison, LS at the P < .001 level of significance showed more extensive and significant hypometabolic areas than did ES. CONCLUSION: These results indicate that LS is superior to ES in detecting hypometabolic regions in patients with AD. For patients with AD, emission scanning soon after the administration of FDG is probably not advised.
• Voxel-based morphometric comparison between early- and late-onset mild Alzheimer's disease and assessment of diagnostic performance of z score images.

  Kazunari Ishii; Takashi Kawachi; Hiroki Sasaki; Atsushi K Kono; Tetsuya Fukuda; Yoshio Kojima; Etsuro Mori

  AJNR. American journal of neuroradiology AMER SOC NEURORADIOLOGY 26 (2) 333 - 40 0195-6108 2005/02 [Refereed]
   

  BACKGROUND AND PURPOSE: Voxel-based morphometry (VBM), used for detecting brain atrophy, permits comparison of local gray matter concentration at every voxel in an image between two groups. We sought to delineate the specific patterns of cerebral gray matter loss with regard to onset of Alzheimer's disease (AD) by using MR imaging and VBM and to evaluate the diagnostic performance of VBM with Z score images. METHODS: Two groups of 30 patients with mild AD of different ages of onset were examined. Mean ages in the early- and late-onset groups were 60.2 +/- 5.2 and 71.5 +/- 2.6 years, respectively. Control subjects were aged-matched healthy volunteers. Regions of gray matter loss in early- and late-onset AD were examined with VBM. Diagnostic performance of Z score images obtained with the VBM method was evaluated in patients and control subjects by calculating the area under the receiver operating characteristic curve (A(z)). RESULTS: Both AD groups had significantly reduced gray matter in the bilateral medial temporal regions. In addition, the early-onset group had more severe gray matter loss in the bilateral parietal and posterior cingulate cortices and precuneus region. No difference was noted in diagnostic performance of Z score images between the early- (A(z) = 0.9435) and late-onset (A(z) = 0.9018) groups. CONCLUSION: Differences were noted in the patterns of regional gray matter loss in patients with early-onset AD versus those with late-onset AD. Parietotemporal and posterior cingulate gray matter loss was found in early-onset AD but not in late-onset AD. Z score images obtained with VBM had a great diagnostic performance for mild AD and can be applied for detecting mild AD in clinical examinations.
• Validation of anatomical standardization of FDG PET images of normal brain: comparison of SPM and NEUROSTAT

  K Hosaka; K Ishii; S Sakamoto; N Sadato; H Fukuda; T Kato; K Sugimura; M Senda

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 32 (1) 92 - 97 1619-7070 2005/01 [Refereed]
   

  Purpose: Statistical parametric mapping (SPM) and NEUROSTAT (NS) are widely used for intersubject statistical analysis of brain images. We investigated individual anatomical variations after standardization of F-18-fluorodeoxyglucose positron emission tomography (FDG PET) images of normal brain and compared the differences in the standardized images obtained from SPM and NS. Methods: Twenty healthy normal subjects were recruited for FDG PET and magnetic resonance imaging (MRI) studies. Sylvian fissures (SF), cingulate sulci (CingS) and central sulci (CtIS) were marked on the brain surface of each individual's co-registered MR images. Then spatial standardization was performed on each subject's PET images using SPM99 and NS with NS's FDG template image, and each subject's MR images (with the SF, CingS, and CtIS marked in advance) were standardized using the sets of parameters obtained from PET standardization by SPM and NS, respectively. The coordinates of each subject's SF, CingS, and CtIS detected on the MR images standardized by the two methods were measured and compared with those on the template images. Results: The mean individual deviations from the averaged coordinates for the markers on the SF, CingS and CtIS standardized by SPM and by NS were no more than 0.21-1.15 mm. The number of voxels within the brain volume on standardized MR images of all 20 subjects was 88.0% of the total number of brain volume voxels for SPM and 85.3% for NS. Conclusion: This study demonstrates that SPM and NS yield relatively small differences in standardization and that both methods are effective and valid for PET studies in normal subjects.
• アルツハイマー病の発症におけるプレセニリン2遺伝子の役割

  YASUDA; Minoru; 石井一成; 橋本衛; 数井裕光; 谷向知; 博野信次; 森悦朗; 片山量平; 富田泰輔; 岩坪威; 権文香; YAMAMOTO, Yasuji; KAWAMATA, Toshio; MAEDA, Kiyoshi

  臨床神経学 44巻, 12号, pp. 1088-1088 (12) 0009-918X 2004/12
• Evaluation of cortical atrophy between progressive supranuclear palsy and corticobasal degeneration by hemispheric surface display of MR images

  M Taki; K Ishii; T Fukuda; Y Kojima; E Mori

  AMERICAN JOURNAL OF NEURORADIOLOGY AMER SOC NEURORADIOLOGY 25 (10) 1709 - 1714 0195-6108 2004/11 [Refereed]
   

  BACKGROUND AND PURPOSE: Three-dimensional imaging and hemispheric volumetry are useful for the assessment of degenerative cortical atrophy. Our purpose was to determine the features of cortical atrophy in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) by means of a hemispheric surface display generated with MR images. METHODS: The extent of cortical atrophy was evaluated with automated MR hemispheric surface display and volumetry in 19 patients with PSP and 19 with CBD. RESULTS: Most cortical regions were less atrophic in PSP than in CBD. The parietal lobe, paracentral regions, anterior middle frontal lobe, and posterior inferior frontal lobe were significantly more atrophic in CBD than in PSP, whereas the brainstem was significantly more atrophic in PSP. The mean hemisphere-to-intracranial volume ratio was significantly greater in patients with PSP (74.5%) than in those with CBD (71.4%), whereas the mean brainstem-to-intracranial volume ratio was significantly smaller in PSP (1.4%) than in CBD (1.6%). Asymmetry of hemispheric volume was significantly larger in the CBD group than in the PSP group. CONCLUSION. Hemispheric surface display and volumetry are generally helpful and especially useful for the differentiation of PSP and CBD.
• Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein

  MX Zhang; K Ishii; H Hisaeda; S Murata; T Chiba; K Tanaka; Y Li; C Obata; M Furue; K Himeno

  IMMUNOLOGY BLACKWELL PUBLISHING LTD 112 (4) 567 - 574 0019-2805 2004/08 [Refereed]
   

  Antitumour immunity against murine melanoma B16 was achieved by genetic immunization with a naked chimeric DNA encoding a fusion protein linking green fluorescent protein (GFP) to the N-terminus of a major CD8(+) cytotoxic T lymphocyte (CTL) epitope of tyrosinase-related protein 2 (TRP-2(181-188)) of murine melanoma, designated as pGFP-TRP-2. Tumour growth was profoundly suppressed in C57BL/6 mice immunized with pGFP-TRP-2, while mice vaccinated with pTRP-2 showed rapid tumour growth and died within 40 days after tumour challenge. Splenocytes of mice immunized with pGFP-TRP-2 showed high CTL activity specific for TRP-2(181-188). GFP-TRP-2 expressed in COS-7 cells was rapidly degradated in vitro and the degradation was almost completely prevented by adding a proteasome inhibitor, MG-132, in the culture. Furthermore, the antimelanoma immunity induced by genetic immunization with pGFP-TRP-2 was completely cancelled in mice deficient in proteasome activator PA28alpha/beta. Taken together, GFP-TRP-2 processed by cytosolic proteasome played a central role in breaking peripheral tolerance to a melanoma/melanocyte antigen, TRP-2(181-188), by activating CD8(+) CTL specific for TRP-2(181-188). TRP-2(181-188) fused to GFP may be readily cut off from GFP by the ubiquitin-fusion degradation (UFD) pathway and efficiently presented to major histocompatibility complex class I molecules, resulting in effective induction of CD8(+) T cells specific for the CTL epitope. Furthermore, CD4(+) T cells specific for GFP were shown to play a crucial role in the antimelanoma immunity, probably potentiating activity of TRP-2-specific CTL and/or the 'ubiquitin-proteasome pathway'. It is noteworthy to document that genetic immunization with pGFP plus pTRP-2(181-188) failed to exert the antitumour immunity.
• Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies.

  Kazunari Ishii; Kayo Hosaka; Tetsuya Mori; Etsuro Mori

  Annals of nuclear medicine JAPANESE SOCIETY NUCLEAR MEDICINE 18 (5) 447 - 51 0914-7187 2004/07 [Refereed]
   

  OBJECTIVES: To investigate regional differences in cerebral glucose metabolism and blood flow of dementia with Lewy bodies (DLB), we studied 7 subjects with DLB and 20 normal controls using F-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET) and then examined the same 7 subjects and 20 other normal controls with I-123 iodoamphetamine (IMP) and single photon emission computed tomography (SPECT). METHODS: The anatomically standardized images were produced with NEUROSTAT and the regional relative metabolic and perfusional values were calculated. RESULTS: The mean reduction ratios of FDG uptake in the DLB group relative to the mean normal controls in the parietal lobe and occipital lobe were 0.72 and 0.83, respectively, while the corresponding mean reduction ratios of IMP uptake were 0.81 and 0.88, respectively. In the DLB group, parietal FDG uptake was significantly lower than parietal IMP uptake (p < 0.05), occipital FDG uptake was significantly lower than occipital IMP uptake (p < 0.05), and parietal IMP uptake was significantly lower than occipital IMP uptake (p < 0.01), but there was no difference between parietal and occipital FDG uptake. CONCLUSIONS: Our findings suggest that parietal metabolism and perfusion are severely affected in DLB patients, though the occipital metabolic and perfusional reduction is thought to be a feature of DLB. FDG-PET is thought to be superior to IMP-SPECT in detecting functional changes in the DLB brain.
• Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with O-15-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan

  H Ito; Kanno, I; C Kato; T Sasaki; K Ishii; Y Ouchi; A Iida; H Okazawa; K Hayashida; N Tsuyuguchi; K Ishii; Y Kuwabara; M Senda

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER-VERLAG 31 (5) 635 - 643 1619-7070 2004/05 [Refereed]
   

  Measurement of cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) by positron emission tomography (PET) with oxygen-15 labelled carbon dioxide ((CO2)-O-15) or O-15-labelled water ((H2O)-O-15), O-15-labelled carbon monoxide ((CO)-O-15) and O-15-labelled oxygen (O-15(2)) is useful for diagnosis and treatment planning in cases of cerebrovascular disease. The measured values theoretically depend on various factors, which may differ between PET centres. This study explored the applicability of a database of O-15-PET by examining between-centre and within-centre variation in values. Eleven PET centres participated in this multicentre study; seven used the steady-state inhalation method, one used build-up inhalation and three used bolus administration of (CO2)-O-15 (or (H2O)-O-15) and O-15(2). All used (CO)-O-15 for measurement of CBV. Subjects comprised 70 healthy volunteers (43 men and 27 women; mean age 51.8+/-15.1 years). Overall mean+/-SD values for cerebral cortical regions were: CBF=44.4+/-6.5 ml 100 ml(-1) min(-1); CBV=3.8+/-0.7 ml 100 ml(-1); OEF=0.44+/-0.06; CMRO2=3.3+/-0.5 ml 100 ml(-1) min(-1). Significant between-centre variation was observed in CBV, OEF and CMRO2 by one-way analysis of variance. However, the overall inter-individual variation in CBF, CBV, OEF and CMRO2 was acceptably small. Building a database of normal cerebral haemodynamics obtained by the(15)O-PET methods may be practicable.
• Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection

  K Onishi; Y Li; K Ishii; H Hisaeda; LJ Tang; XF Duan; T Dainichi; Y Maekawa; N Katunuma; K Himeno

  MICROBES AND INFECTION ELSEVIER SCIENCE BV 6 (5) 468 - 474 1286-4579 2004/04 [Refereed]
   

  Prior to the activation of CD4(+) T cells, exogenous proteins are digested by endo/lysosomal enzymes in antigen-presenting cells (APCs) to produce antigenic peptides that are presented on MHC class II molecules. In the studies described here, the functional significance of cathepsin L for antigen processing and Th1/Th2 differentiation in experimental leishmaniasis was investigated. We first demonstrated that cathepsin L is one of the candidates for endo/lysosomal enzymes in the processing of soluble Leishmania antigen (SLA) by using CLIK148, a specific inhibitor of cathepsin L. Treatment of BALB/c or DBA/2 mice with CLIK148 exacerbated the disease by enhancing an SLA-specific Th2-type response such as IL-4 production. CLIK148 did not exert any direct influence on Leishmania major promastigotes themselves or on the course of L. major infection in SCID mice. Taken together, these findings suggest that treatment of host mice with CLIK148 affects the processing of SLA in APCs, resulting in the potentiation of Th2-type immune responses and thus leading to exacerbation of the disease. Furthermore, endo/lysosomal cathepsin L was found to be functionally distinct from previously described cathepsins B and D. (C) 2004 Elsevier SAS. All rights reserved.
• Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis

  Atsushi Yamanaka; Shinjiro Hamano; Yoshiyuki Miyazaki; Kazunari Ishii; Atsunobu Takeda; Tak W. Mak; Kunisuke Himeno; Akihiko Yoshimura; Hiroki Yoshida

  Journal of Immunology American Association of Immunologists 172 (6) 3590 - 3596 0022-1767 2004/03 [Refereed]
   

  Administration of Con A induces liver injury that is considered to be an experimental model for human autoimmune or viral hepatitis, where immunopathology plays roles mediated by activated lymphocytes, especially NK1.1+ CD3+ NKT cells, and inflammatory cytokines, including IFN-γ and IL-4. In the present study we investigated the role of WSX-1, a component of IL-27R, in Con A-induced hepatitis by taking advantage of WSX-1 knockout mice. WSX-1-deficient mice were more susceptible to Con A treatment than wild-type mice, showing serum alanine aminotransferase elevation and massive necrosis in the liver. Although the development of NKT cells appeared normal in WSX-1 knockout mice, purified NKT cells from the knockout mice produced more IFN-γ and IL-4 than those from wild-type mice in response to stimulation with Con A both in vitro and in vivo. In addition, hyperproduction of proinflammatory cytokines, including IL-1, IL-6, and TNF-α, was observed in the knockout mice after Con A administration. These data revealed a novel role for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis.
• One-year change in cerebral glucose metabolism in patients with Alzheimer's disease

  Nobutsugu Hirono; Mamoru Hashimoto; Kazunari Ishii; Hiroaki Kazui; Etsuro Mori

  Journal of Neuropsychiatry and Clinical Neurosciences American Psychiatric Publishing Inc. 16 (4) 488 - 492 0895-0172 2004 [Refereed]
   

  By using [18F]-2-fluoro-deoxy-D-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer's disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.
• Clinical FDG-PET for dementia in Japan: current status and cost-effectiveness analysis

  M Senda; Y Ouchi; K Ishii; K Ishii; S Ikeda

  PET AND MOLECULAR IMAGING: STATE OF THE ART AND FUTURE PERSPECTIVES ELSEVIER SCIENCE BV 1264 33 - 39 0531-5131 2004 [Refereed]
   

  In a Japanese nationwide survey on the use of FDG-PET for dementia, a total of 406 cases acquired during the period from April 2001 to March 2002 were collected from 15 PET centers. The purpose of the PET scans included (A) diagnosis of patients with memory disturbance for possible early stage of Alzheimer's disease (154 cases) and (B) differential diagnosis for dementia-related neurodegenerative diseases (144 cases), and the PET achieved the purpose in most cases. Based on the survey, an economic evaluation was performed on the 2-year projected cost and benefit of treating patients with donepezil that are diagnosed as Alzheimer's disease with FDG-PET. The estimation indicated that early and/or accurate diagnosis of Alzheimer's disease with FDG-PET followed by initiation of the donepezil treatment would delay the disease progress and reduce the care cost more than it would increase the cost by the PET and the drug therapy. The average reduction of the total cost was estimated to be Y61 500 (A) and Y 13 700 (B) per person. The increase of the quality adjusted life year (QALY) was predicted to be 0.044 (A) and 0.014 (B). Therefore, incorporation of PET into the clinical path was shown to be economically dominant. (C) 2004 Elsevier B.V. All rights reserved.
• One-year change in cerebral glucose metabolism in patients with Alzheimer's disease

  Nobutsugu Hirono; Mamoru Hashimoto; Kazunari Ishii; Hiroaki Kazui; Etsuro Mori

  Journal of Neuropsychiatry and Clinical Neurosciences American Psychiatric Publishing Inc. 16 (4) 488 - 492 0895-0172 2004 [Refereed]
   

  By using [18F]-2-fluoro-deoxy-D-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer's disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.
• Glucose metabolic dysfunction in subjects with a clinical dementia rating of 0.5.

  Kazunari Ishii; Tetsuya Mori; Nobutsugu Hirono; Etsuro Mori

  Journal of the neurological sciences ELSEVIER SCIENCE BV 215 (1-2) 71 - 4 0022-510X 2003/11 [Refereed]
   

  OBJECTIVE: To investigate the cerebral glucose metabolism of subjects who had a Clinical Dementia Rating (CDR) of 0.5, we studied 40 subjects whose CDR was 0.5 and 40 age-matched healthy subjects. METHODS: Cerebral glucose image of each subject was obtained by [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET). The anatomically standardized images were produced with NEUROSTAT. Then, the two groups were compared with the Statistical Parametric Mappings (SPM) 99. RESULTS: A comparison with the SPM 99 revealed that relative cerebral glucose metabolism was lower in the posterior cingulate gyri and parietal lobules in the CDR 0.5 group than in the healthy subjects group. CONCLUSION: These findings are very similar to those in patients with probable Alzheimer's disease (AD) and suggest that the majority of subjects with CDR 0.5 are suffering from very mild AD or at least a prodromal state of AD.
• Glucose metabolic dysfunction in subjects with a Clinical Dementia Rating of 0.5

  K Ishii; T Mori; N Hirono; E Mori

  JOURNAL OF THE NEUROLOGICAL SCIENCES ELSEVIER SCIENCE BV 215 (1-2) 71 - 74 0022-510X 2003/11 [Refereed]
   

  Objective: To investigate the cerebral glucose metabolism of subjects who had a Clinical Dementia Rating (CDR) of 0.5, we studied 40 subjects whose CDR was 0.5 and 40 age-matched healthy subjects. Methods: Cerebral glucose image of each subject was obtained by [F-18]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET). The anatomically standardized images were produced with NEUROSTAT. Then, the two groups were compared with the Statistical Parametric Mappings (SPM) 99. Results: A comparison with the SPM 99 revealed that relative cerebral glucose metabolism was lower in the posterior cingulate gyri and parietal lobules in the CDR 0.5 group than in the healthy subjects group. Conclusion: These findings are very similar to those in patients with probable Alzheimer's disease (AD) and suggest that the majority of subjects with CDR 0.5 are suffering from very mild AD or at least a prodromal state of AD. (C) 2003 Elsevier B.V. All rights reserved.
• Striatal infarcts mimicking frontotemporal dementia: A case report

  Y. Nishio; Y. Nakano; K. Matsumoto; M. Hashimoto; H. Kazul; N. Hirono; K. Ishii; Etsuro Mori

  European Journal of Neurology 10 (4) 457 - 460 1351-5101 2003/07 

  We described a patient with bilateral striatal infarcts, in whom stereotyped and disinhibited behaviors were insidiously emerged over 2 years mimicking frontotemporal dementia (FTD). A positron emission tomography with 18-fluorodeoxy glucose showed a hypometabolism in the frontal lobes, basal ganglia, and thalami. The peculiar behavioral alterations remained unchanged for the following 7 years, suggesting that the disease is not degenerative but of vascular origin. A disruption of the fronto-subcortical circuits at the level of the striatum or the anterior thalamic peduncle is attributable to the FTD-like behavioral and cognitive syndrome. © 2003 EFNS.
• Prediction of hyperperfusion after carotid endarterectomy by brain SPECT analysis with semiquantitative statistical mapping method.

  Kohkichi Hosoda; Tetsuro Kawaguchi; Kazunari Ishii; Satoshi Minoshima; Yuji Shibata; Masaki Iwakura; Shigeo Ishiguro; Eiji Kohmura

  Stroke LIPPINCOTT WILLIAMS & WILKINS 34 (5) 1187 - 93 0039-2499 2003/05 [Refereed]
   

  BACKGROUND AND PURPOSE: Hyperperfusion syndrome is a rare but disastrous complication after carotid endarterectomy (CEA). The aim of this study was to investigate the relationship between preoperative cerebral blood flow (CBF) abnormalities and postoperative hyperperfusion through the use of statistical brain mapping analysis. METHODS: For 41 patients with unilateral carotid stenosis >or=70%, CBF and cerebral vasoreactivity (CVR) were investigated with resting and acetazolamide-challenge single photon emission CT before CEA. CBF 1 day after CEA was also measured. Three-dimensional stereotactic surface projection (3D-SSP) analysis of CBF changes was performed by use of a control database of 20 subjects. RESULTS: Patients with reduced CVR (CVR <10%, n=15) were categorized into 2 groups based on the severity of CBF reduction relative to the control database by 3D-SSP analysis without normalization: type I (ipsilateral CBF decrease <20%, n=8) and type II (ipsilateral CBF decrease >or=20%, n=7). With thalamic normalization, the patients were also categorized into 2 groups: type A (ipsilateral Z score 2, n=5). Severe CBF reduction (>or=20% or Z score >2) was significantly associated with postoperative hyperperfusion (CBF increase >or=100%). However, 3D-SSP with thalamic normalization (Z score) demonstrated a higher predictive value (80%) and specificity (91%) for hyperperfusion than 3D-SSP without normalization (percent reduction) (57% and 73%, respectively). No patients with normal CVR (CVR >or=10%, n=26) demonstrated postoperative hyperperfusion. CONCLUSIONS: Objective evaluation of abnormalities of CBF and CVR with 3D-SSP could identify patients at risk for postoperative hyperperfusion.
• Lewy小体性痴呆における18FDG-PETと123I-IMP SPECTの所見の対比

  保坂 加代; 山口 雅人; 福島 和人; 杉村 和朗; 石井 一成

  日本医学放射線学会雑誌 (公社)日本医学放射線学会 63 (3) 114 - 115 0048-0428 2003/02 [Refereed]
  
• Clinical application of positron emission tomography for diagnosis of dementia.

  Kazunari Ishii

  Annals of nuclear medicine JAPANESE SOCIETY NUCLEAR MEDICINE 16 (8) 515 - 25 0914-7187 2002/12 [Refereed]
   

  Clinical applications of PET studies for dementia are reviewed in this paper. At the mild and moderate stages of Alzheimer's disease (AD), glucose metabolism is reduced not only in the parietotemporal region but also in the posterior cingulate and precuneus. At the advanced stage of AD, there is also a metabolic reduction in the frontal region. In AD patients, glucose metabolism is relatively preserved in the pons, sensorimotor cortices, primary visual cortices, basal ganglia, thalamus and cerebellum. In patients with dementia with Lewy bodies, glucose metabolism in the primary visual cortices is reduced, and this reduction appears to be associated with the reduction pattern in AD patients. In patients with frontotemporal dementia, reduced metabolism in the frontotemporal region is the main feature of this disease, but reduced metabolism in the basal ganglia, and/or parietal metabolic reduction can be associated with the frontotemporal reduction. When corticobasal degeneration is associated with dementia, the reduction pattern of dementia is similar to the reduction pattern in AD and the hallmarks of diagnosing corticobasal degeneration associated with dementia are a reduced metabolism in the primary sensorimotor region and/or basal ganglia and an asymmetric reduction in the two hemispheres. FDG-PET is a very useful tool for the diagnosis of early AD and for the differential diagnosis of dementia. I also describe clinical applications of PET for the diagnosis of dementia in Japan.
• Differences in cerebral metabolic impairment between early and late onset types of Alzheimer's disease.

  Setsu Sakamoto; Kazunari Ishii; Masahiro Sasaki; Kayo Hosaka; Tetsuya Mori; Mieko Matsui; Nobutsugu Hirono; Etsuro Mori

  Journal of the neurological sciences ELSEVIER SCIENCE BV 200 (1-2) 27 - 32 0022-510X 2002/08 [Refereed]
   

  UNLABELLED: The purpose of this study was to delineate the specific patterns of cerebral glucose metabolism with regard to the time of onset of Alzheimer's disease (AD). METHODS: Two groups of 20 AD patients with different ages of onset were examined. The early onset (EO) and late onset (LO) groups had mean ages of onset of 53.9 and 72.7 years. Groups of age-matched normal subjects were used as controls. A regional relative cerebral glucose metabolic image of each subject was obtained by 2-[18F] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). NEUROSTAT program was used for spatial normalization and voxel-based statistical parametric mapping (SPM) 99 was used for statistical analyses. RESULTS: Both AD groups had significant hypometabolic regions in the bilateral parieto-temporal regions compared with the age-matched groups. The EO group had more severe hypometabolism in the bilateral parietal and posterior cingulate cortices and precuneus region than the LO group. However, LO group showed no significant hypometabolic regions compared to the EO group. CONCLUSION: The effects of time of AD onset were delineated as a double dissociation, that is, EO AD patients have a more severe reduction of glucose metabolism. Our finding suggests the existence of biological subtypes of AD.
• Differences in cerebral metabolic impairment between early and late onset types of Alzheimer's disease

  S Sakamoto; K Ishii; M Sasaki; K Hosaka; T Mori; M Matsui; N Hirono; E Mori

  JOURNAL OF THE NEUROLOGICAL SCIENCES ELSEVIER SCIENCE BV 200 (1-2) 27 - 32 0022-510X 2002/08 [Refereed]
   

  The purpose of this study was to delineate the specific patterns of cerebral glucose metabolism with regard to the time of onset of Alzheimer's disease (AD). Methods: Two groups of 20 AD patients with different ages of onset were examined. The early onset (EO) and late onset (LO) groups had mean ages of onset of 53.9 and 72.7 years. Groups of age-matched normal subjects were used as controls. A regional relative cerebral glucose metabolic image of each subject was obtained by 2-[F-18] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). NEUROSTAT program was used for spatial normalization and voxel-based statistical parametric mapping (SPM) 99 was used for statistical analyses. Results: Both AD groups had significant hypometabolic regions in the bilateral parieto-temporal regions compared with the age-matched groups. The EO group had more severe hypometabolism in the bilateral parietal and posterior cingulate cortices and precuneus region than the LO group. However, LO group showed no significant hypometabolic regions compared to the EO group. Conclusion: The effects of time of AD onset were delineated as a double dissociation, that is, EO AD patients have a more severe reduction of glucose metabolism. Our finding suggests the existence of biological subtypes of AD. (C) 2002 Elsevier Science B.V. All rights reserved.
• Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration.

  Kayo Hosaka; Kazunari Ishii; Setsu Sakamoto; Tetsuya Mori; Masahiro Sasaki; Nobutsugu Hirono; Etsuro Mori

  Journal of the neurological sciences ELSEVIER SCIENCE BV 199 (1-2) 67 - 71 0022-510X 2002/07 [Refereed]
   

  OBJECTIVES: Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative disorders that may be accompanied by dementia and parkinsonism as clinical symptoms. The purpose of this study was to elucidate cerebral metabolic differences of these two diseases with cognitive impairments by [18F] fluorodeoxyglucose (FDG) and positron emission tomography (PET). METHODS: A total of 12 patients with PSP (age: 62.8+/-6.0 years old, m: 7, f: 5, Mini-Mental State Examination (MMSE): 23.4+/-2.6), 12 patients with CBD (age: 64.8+/-6.3 years old, m: 6, f: 6, MMSE: 22.9+/-4.5), and age-matched healthy subjects (normal control (NC)) (age: 63.8+/-7.7 years old, m: 7, f: 5) were subjected to FDG-PET to obtain glucose metabolic images. We compared regional cerebral metabolic images by a voxel-by-voxel analysis with statistical parametric mapping (SPM) among PSP, CBD, and NC subjects, and evaluated differences of hypometabolic regions. RESULTS: The patients with PSP showed reduced cerebral glucose metabolism in the medial and lateral frontal gyri, basal ganglia, and midbrain compared with NC, whereas the patients with CBD showed significant reduction in the parietal lobes (p<0.001). SPM also revealed parietal hypometabolism in CBD patients compared with PSP patients (p<0.001). CONCLUSIONS: The predominant parietal glucose metabolic reduction in CBD patients was different from previously reported findings. This finding would be the characteristic substance of patients with CBD accompanying cognitive impairments. Our findings suggest that measurement of glucose metabolism by PET and a voxel-based analysis is useful to understand the pathophysiology of these two diseases with cognitive impairments.
• Gender differences in cerebral glucose metabolism: a PET study.

  Takashi Kawachi; Kazunari Ishii; Setsu Sakamoto; Mieko Matsui; Tetsuya Mori; Masahiro Sasaki

  Journal of the neurological sciences ELSEVIER SCIENCE BV 199 (1-2) 79 - 83 0022-510X 2002/07 [Refereed]
   

  OBJECTIVE: Some studies have examined gender differences in brain function based on cerebral blood flow and cerebral metabolism by using positron emission tomography (PET). However, the findings of these studies are controversial and most of them were analyzed by the regions of interest (ROIs) method. Here, we evaluated gender differences of cerebral glucose metabolism under the resting state in a voxel-based analysis. METHODS: We studied 44 healthy volunteers (22 females, 63.0+/-6.3 years, and 22 males, 63.1+/-8.4 years). Cerebral glucose metabolic images were obtained with (18)F-fluorodeoxyglucose (FDG) and PET. All individual data were transformed to standard brain space and the male and female groups were compared using statistical parametric mapping (SPM). RESULTS: The males had significantly higher glucose metabolism in the right insula, middle temporal gyrus, and medial frontal lobe than the females. Glucose metabolism in the hypothalamus was significantly higher in females than in males. There was a significant correlation between aging and glucose metabolism in the left thalamus in males and in the left caudate nucleus and hypothalamus in females. In males, but not females, there was a significant asymmetry between the bilateral hemispheres. CONCLUSION: We found that there were obvious gender differences in regional cerebral glucose metabolism and this is the first report of higher glucose metabolism in the hypothalamus in females than in males.
• Gender differences in cerebral glucose metabolism: a PET study

  T Kawachi; K Ishii; S Sakamoto; M Matsu; T Mori; M Sasaki

  JOURNAL OF THE NEUROLOGICAL SCIENCES ELSEVIER SCIENCE BV 199 (1-2) 79 - 83 0022-510X 2002/07 [Refereed]
   

  Objective: Some studies have examined gender differences in brain function based on cerebral blood flow and cerebral metabolism by using positron emission tomography (PET). However, the findings of these studies are controversial and most of them were analyzed by the regions of interest (ROls) method. Here, we evaluated gender differences of cerebral glucose metabolism under the resting state in a voxel-based analysis. Methods: We studied 44 healthy volunteers (22 females, 63.0 +/- 6.3 years, and 22 males, 63.1 +/- 8.4 years). Cerebral glucose metabolic images were obtained with F-18-fluorodeoxyglucose (FDG) and PET. All individual data were transformed to standard brain space and the male and female groups were compared using statistical parametric mapping (SPM). Results: The males had significantly higher glucose metabolism in the right insula, middle temporal gyrus, and medial frontal lobe than the females. Glucose metabolism in the hypothalamus was significantly higher in females than in males. There was a significant correlation between aging and glucose metabolism in the left thalamus in males and in the left caudate nucleus and hypothalamus in females. In males, but not females, there was a significant asymmetry between the bilateral hemispheres. Conclusion: We found that there were obvious gender differences in regional cerebral glucose metabolism and this is the first report of higher glucose metabolism in the hypothalamus in females than in males. (C) 2002 Elsevier Science B.V All rights reserved.
• Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration

  K Hosaka; K Ishii; S Sakamoto; T Mori; M Sasaki; N Hirono; E Mori

  JOURNAL OF THE NEUROLOGICAL SCIENCES ELSEVIER SCIENCE BV 199 (1-2) 67 - 71 0022-510X 2002/07 [Refereed]
   

  Objectives: Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative disorders that may be accompanied by dementia and parkinsonism as clinical symptoms. The purpose of this study was to elucidate cerebral metabolic differences of these two diseases with cognitive impairments by [F-18] fluorodeoxyglucose (FDG) and positron emission tomography (PET). Methods: A total of 12 patients with PSP (age: 62.8 +/- 6.0 years old, m: 7, f: 5, Mini-Mental State Examination (MMSE): 23.4 +/- 2.6), 12 patients with CBD (age: 64.8 +/- 6.3 years old, in: 6, If: 6, MMSE: 22.9 +/- 4.5), and age-matched healthy subjects (normal control (NC)) (age: 63.8 +/- 7.7 years old, in: 7, f. 5) were subjected to FDG-PET to obtain glucose metabolic images. We compared regional cerebral metabolic images by a voxel-by-voxel analysis with statistical parametric mapping (SPM) among PSP, CBD, and NC subjects, and evaluated differences of hypometabolic regions. Results: The patients with PSP showed reduced cerebral glucose metabolism in the medial and lateral frontal gyri, basal ganglia, and midbrain compared with NC, whereas the patients with CBD showed significant reduction in the parietal lobes (p <0.001). SPM also revealed parietal hypometabolism in CBD patients compared with PSP patients (p <0.001). Conclusions: The predominant parietal glucose metabolic reduction in CBD patients was different from previously reported findings. This finding would be the characteristic substance of patients with CBD accompanying cognitive impairments. Our findings suggest that measurement of glucose metabolism by PET and a voxel-based analysis is useful to understand the pathophysiology of these two diseases with cognitive impairments. (C) 2002 Elsevier Science B.V. All rights reserved.
• Variation in FDG uptakes in different regions in normal human brain as a function of the time (30 and 60 minutes) after injection of FDG.

  Kazunari Ishii; Setsu Sakamoto; Kayo Hosaka; Tetsuya Mori; Masahiro Sasaki

  Annals of nuclear medicine JAPANESE SOCIETY NUCLEAR MEDICINE 16 (4) 299 - 301 0914-7187 2002/06 [Refereed]
   

  OBJECTIVE: The authors' goal was to determine whether FDG uptakes in various regions of the brain are different for early and late scanning time in positron emission tomography (PET). METHOD: F-18 fluorodeoxyglucose (FDG) PET was performed on 15 healthy normal subjects to obtain early and late acquisition glucose metabolic images (30 and 60 min after FDG injection), respectively. The two sets of images were compared in a voxel-by-voxel analysis. RESULTS: In the bilateral posterior cingulate gyrus, parietal and frontal association cortices, and subcallosal cortices, the FDG uptakes were larger on the late scan image than on the early scan image, and the FDG uptakes were larger in the cerebellar hemisphere, vermis and frontal basis on the early scan image than on the late scan image. CONCLUSIONS: These results suggest that there are different regional FDG uptakes depending on the scanning time after FDG injection and we must be careful in replacing conventional FDG PET scanning with early scanning in FDG PET study.
• The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset.

  N Hirono; M Hashimoto; M Yasuda; K Ishii; S Sakamoto; H Kazui; E Mori

  Neurology Lippincott Williams and Wilkins 58 (5) 743 - 50 0028-3878 2002/03 [Refereed]
   

  BACKGROUND: Although the APOE epsilon4 allele is a well-known risk factor for developing AD, the impact of the epsilon4 allele on clinical manifestations in patients with AD is still controversial. One possible reason for this controversy is that previous studies did not consider the effect of patient age at symptom onset. OBJECTIVE: To investigate the possible impact of patient age at onset of AD on the effect of APOE genotype on regional cerebral glucose metabolism (rCMRglc). METHODS: The authors compared rCMRglc between probable AD patients (based on criteria of the National Institute of Neurologic Disease and Stroke/AD and Related Disorders Association) with APOE epsilon4/4 and APOE epsilon3/3 alleles in early-onset (< or =65 years old) and late-onset (>65 years old) groups. In each group, the patients with APOE epsilon4/4 and APOE epsilon3/3 alleles were comparable for age at onset, age at examination, sex, disease duration, education level, and severity of dementia. RESULTS: In the early-onset group, the patients with the APOE epsilon4/4 genotype showed a significant decrease of rCMRglc in the medial temporal lobe and a significant increase of rCMRglc in the inferior parietal and posterior temporal cortices as compared with those patients with the APOE epsilon3/3 genotype. In the late-onset group, there were no significant differences in the rCMRglc pattern between the patients with APOE epsilon4/4 and APOE epsilon3/3 alleles. CONCLUSIONS: The current findings indicate that the impact of the APOE epsilon4 genotype on cerebral glucose metabolism of patients with AD may be a function of age at symptom onset.
• Transient global amnesia: increased signal intensity in the right hippocampus on diffusion-weighted magnetic resonance imaging.

  M Matsui; T Imamura; S Sakamoto; K Ishii; H Kazui; E Mori

  Neuroradiology 44 (3) 235 - 8 0028-3940 2002/03 [Refereed]
   

  We report on a patient with pure transient global amnesia (TGA) whose magnetic resonance imaging (MRI) demonstrated a small region of increased signal intensity in the right hippocampus on diffusion-weighted imaging (DWI). DWI was sensitive and useful for evaluating the early stage of TGA and might help to explain the pathophysiology of TGA.
• A convenient cancer vaccine therapy with in vivo transfer of interleukin 12 expression plasmid using gene gun technology after priming with irradiated carcinoma cells

  M Nishitani; T Sakai; K Ishii; MX Zhang; Y Nakano; Y Nitta; J Miyazaki; H Kanayama; S Kagawa; K Himeno

  CANCER GENE THERAPY NATURE PUBLISHING GROUP 9 (2) 156 - 163 0929-1903 2002/02 [Refereed]
   

  We studied interleukin (IL)-12 gene therapy using a gene gun as a new autologous vaccination strategy tor cancer. In the first experiment, BALB/c mice were inoculated with syngeneic murine renal cancer cells (Renca) intradermally in the abdomen. This was followed by an injection of IL-12 expression plasmid using the gene gun. About 40%. of the mice exhibited rejection of the tumor after the treatment and these mice also acquired immunological resistance against a secondary challenge with Renca cells. Based on these results, we examined whether antitumor activity can be potentiated when mice undergo combination treatment with intradermal inoculation of irradiated Renca cells and transfection with IL-12 gene. Inoculation of irradiated Renca cells alone was partially effective in inducing antitumor immunity, whereas the combined treatment remarkably intensified this effect. Moreover, this combined treatment inhibited tumor establishment and enhanced survival of the mice with tumor infiltration by CD4(+) and CD8(+) T cells, even when the treatment was started after tumor-implantation at a distant site. This antitumor effect was antigen specific and we confirmed the induction of antitumor cytotoxic T cells by this treatment. These results show that. local cutaneous transfer of IL-12 expression plasmid using gene gun technology enhances systemic and specific antitumor immunity primed by irradiated tumor cells.
• Occipital glucose metabolism in dementia with Lewy bodies with and without parkinsonism: A study using positron emission tomography

  T Imamura; K Ishii; N Hirono; M Hashimoto; S Tanimukai; H Kazui; T Hanihara; M Sasaki; E Mori

  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS KARGER 12 (3) 194 - 197 1420-8008 2001/05 

  Reduction of glucose metabolism in the occipital lobe is reported in dementia with Lewy bodies (DLB) and Parkinson's disease. If dysfunction of the nigrostriatal system is responsible for occipital hypometabolism, (1) DLB patients with parkinsonism would show a lower occipital metabolism than do patients without parkinsonism, and (2) DLB patients without parkinsonism would show an occipital metabolism comparable to those of normal subjects and patients with Alzheimer's disease (AD). To examine these hypotheses, we studied the regional cerebral metabolic rate of glucose (rCMRglc) in patients with a clinical diagnosis of DLB or AD, using F-18-fluorodeoxyglucose and positron emission tomography. The subjects consisted of 15 DLB patients with parkinsonism, 7 DLB patients without parkinsonism and 7 AD patients without parkinsonism. The medial and lateral occipital rCMRglc was significantly lower in the DLB patients without parkinsonism than in the AD patients. There were no significant differences in occipital metabolic rates be-tween the DLB groups with and without parkinsonism, DLB patients without parkinsonism showed a significant reduction of occipital glucose metabolism which is comparable with that of DLB patients with parkinsonism. The neurobiological bases of occipital hypometabolism in DLB may be pathological processes in the brainstem or basal forebrain structures other than the nigrostriatal system. Copyright (C) 2001 S. Karger AG, Basel.
• Neuronal substrates for semantic memory: A positron emission tomography study in Alzheimer's disease

  N Hirono; E Mori; K Ishii; T Imamura; S Tanimukai; H Kazui; M Hashimoto; Y Takatsuki; H Kitagaki; M Sasaki

  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS KARGER 12 (1) 15 - 21 1420-8008 2001/01 

  We examined 57 patients with mild Alzheimer's disease by using three kinds of verbal semantic memory tests (category fluency, confrontation naming and generation of verbal definition) and correlated each score with regional cerebral glucose metabolism determined by F-18-fluorodeoxyglucose a nd positron emission tomography, The scores of all three verbal semantic memory tests correlated significantly with regional cerebral glucose metabolism in the left inferior temporal gyrus, even after controlling for the effects of age, sex and educational attainment. In contrast, the scores of the word recall rest did not correlate significantly with regional cerebral glucose metaboliosm in the left inferior temporal gyrus, neither before nor after controlling for these confounders. Our results suggested that the left: inferior temporal lobe contributes to verbal semantic memory. Copyright (C) 2001 S. Karger AG, Basel.
• A diagnostic method for suspected Alzheimer's disease using H(2)15O positron emission tomography perfusion Z score.

  K Ishii; M Sasaki; M Matsui; S Sakamoto; S Yamaji; N Hayashi; T Mori; H Kitagaki; N Hirono; E Mori

  Neuroradiology SPRINGER-VERLAG 42 (11) 787 - 94 0028-3940 2000/11 [Refereed]
   

  We developed cerebral perfusion Z score map (Z map) images using H(2)15O and positron emission tomography (PET), and examined their use in diagnosing Alzheimer's disease (AD). Cerebral blood flow (CBF) images were obtained using the PET and H(2)15O autoradiographic method. The best region for normalising the CBF value to remove individual variantion was determined. Then CBF images were transformed to Talairach's standard space, and each pixel value of an individual's image set was normalized to the mean value of the sensorimotor area. Based on the CBF images of 20 normal volunteers, normative mean and standard deviation (SD) CBF images were constructed. Then, each pixel value of the axial CBF images in 28 patients with probable AD and 10 further normal volunteers was converted to a Z score (Z = [normal mean--individual value]/normal SD). A Z map, showing pixels exceeding a threshold of Z score > 2 on MRI of standardised anatomical space was demonstrated. These 38 Z maps were interpreted by four radiologists. When regions in the temporoparietal area were found with Z scores > 2, the subject was diagnosed as having AD. A receiver operating characteristic (ROC) analysis was performed to compare the conventional CBF images and Z maps. The diagnostic performance of the Z map was superior to that of visual inspection of conventional CBF images (mean areas under the ROC curve of the four radiologists were 0.946 and 0.584, respectively). These results indicate that a Z map obtained in this way is superior to conventional PET for diagnosing AD.
• Noninvasive estimation of FDG input function for quantification of cerebral metabolic rate of glucose: Optimization and multicenter evaluation

  T Shiozaki; N Sadato; M Senda; K Ishii; T Tsuchida; Y Yonekura; H Fukuda; J Konishi

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 41 (10) 1612 - 1618 0161-5505 2000/10 [Refereed]
   

  The aims of this study were to determine whether body weight or body surface area (BSA) should be used for noninvasive measurement of the cerebral metabolic rate of glucose (CMRGIc) by FDG PET with a standardized input function (SIF) and an autoradiographic method and to validate the procedure in a large population from different PET centers. Methods: Plasma input functions measured by intermittent arterial blood sampling after intravenous injection of FDG, in 101 patients from 1 institution who were fasting for at least 4 h, were used to generate the SIF. The SIF was generated by averaging over 101 patients the input function normalized with the net injected dose and initial distribution volume (DV) of FDG estimated by the formula c x H-a X W-b, where H is body height and W is body weight. To evaluate the estimation of DV by BSA or body weight, the coefficient of variation (CV) of the ratio of Ha X Wb to the measured DV was calculated by changing a and b independently. Estimation of the CMRGIc with SIF based on the formula for DV was validated with an additional 192 subjects from 3 institutions who underwent FDG PET while fasting. The result of simulation was compared with the results of 4 previously published formulas for BSA and body weight. Results: The optimal set of parameters, in which a was 0.80 and b was 0.35, minimized the CV. The averaged percentage error of the CMRGIc based on the optimal set of parameters for DV estimation and SIF was 8.9% for gray matter and 10.6% for white matter. Four BSA formulas brought about a similar error, which was significantly smaller than that based on body weight (P < 0.001, ANOVA). Conclusion: Noninvasive estimation of CMRGIc is made possible by careful measurement of the net injected dose and BSA.
• Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images.

  H Kitagaki; N Hirono; K Ishii; E Mori

  Radiology RADIOLOGICAL SOC NORTH AMER 216 (1) 31 - 8 0033-8419 2000/07 [Refereed]
   

  PURPOSE: To determine the characteristics of cortical atrophy in corticobasal degeneration and Alzheimer disease by using a hemispheric surface display generated with magnetic resonance (MR) images. MATERIALS AND METHODS: The magnitude and extent of cortical atrophy were evaluated with MR hemispheric surface display and volumetric measurement in three groups: 17 patients with corticobasal degeneration, 17 matched patients with Alzheimer disease, and 17 matched healthy control subjects. RESULTS: The extent and magnitude of cortical atrophy were larger in the group with corticobasal degeneration than in the group with Alzheimer disease. The parasagittal and paracentral regions were significantly more atrophic in patients with corticobasal degeneration than in patients with Alzheimer disease (P <.05). The mean hemispheric-to-total intracranial volume ratios were significantly smaller in the patients with corticobasal degeneration (61%) and those with Alzheimer disease (64%) than in control subjects (69%). Asymmetry of hemispheric volume was significantly larger in the group with corticobasal degeneration than in the control group. CONCLUSION: The extent of cortical atrophy in corticobasal degeneration is more widespread than was previously thought. Parasagittal and paracentral atrophy is a distinctive feature of corticobasal degeneration and distinguishes it from Alzheimer disease.
• Regional differences in cerebral blood flow during recitation of the multiplication table and actual calculation: a positron emission tomography study.

  N Hayashi; K Ishii; H Kitagaki; H Kazui

  Journal of the neurological sciences ELSEVIER SCIENCE BV 176 (2) 102 - 8 0022-510X 2000/06 [Refereed]
   

  UNLABELLED: Regional cerebral differences in activation by two types of calculation, quantitative number processing and use of rote verbal arithmetic memory, were investigated. METHODS: The two types of processing were induced by serial number subtraction (the Subtra-task) and recitation of the multiplication table (the Multi-task), respectively. Regional cerebral blood flow (rCBF) under the two tasks was measured in ten healthy right-handed Japanese men using (15)O-labeled water and positron emission tomography (PET). Statistical parametric mapping (SPM) was used for estimating rCBF differences during these tasks. RESULTS: The activated areas during the Subtra-task were consistent with those reported to be involved in quantitative number processing. Although most of the regions activated during the Multi-task were in common with the regions activated during the Subtra-task, the spatial extent of the activation during the Multi-task was smaller. Moreover, the left lenticular nucleus was activated during the Multi-task, but not in the Subtra-task, while the prefrontal cortex was activated in the Subtra-task but not in the Multi-task. CONCLUSION: The difference in the regions activated by the two tasks, and the difference in the spatial extent of each region by the two tasks indicated that the anatomical networks of the two processes were segregated.
• Disturbances of spatial vision and object vision correlate differently with regional cerebral glucose metabolism in Alzheimer's disease.

  M Fujimori; T Imamura; N Hirono; K Ishii; M Sasaki; E Mori

  Neuropsychologia PERGAMON-ELSEVIER SCIENCE LTD 38 (10) 1356 - 61 0028-3932 2000 [Refereed]
   

  There is evidence of two neuronal systems for visual cognition which are referred to as spatial vision and object vision. We subjected 49 patients with mild-to-moderate probable Alzheimer's disease (AD) to tasks associated with these two types of visual cognition. Visual counting was employed as a task to assess visuospatial recognition. Identification of overlapping figures and discrimination of visual forms were used as visuoperceptual tasks that require an ability to recognize objects. Regional cerebral glucose metabolism (rCMRglc) of the subjects was also determined by positron emission tomography. Multivariate statistics controlling for the confounding factors assessed the correlation between the task performances and the rCMRglc. The visual counting score significantly correlated with the metabolic rate of the bilateral inferior parietal lobules. On the other hand, the scores of the visuoperceptual tasks significantly correlated with the metabolic rate of the right middle temporal gyrus and the right inferior parietal lobule. The present study showed that visuospatial disturbance was related to bilateral parietal metabolism, and that visuoperceptual disturbance was related to right temporo-parietal metabolism in patients with mild-to-moderate AD.
• Evaluation of standardized uptake value to assess cerebral glucose metabolism.

  S Yamaji; K Ishii; M Sasaki; T Mori; H Kitagaki; S Sakamoto; E Mori

  Clinical nuclear medicine LIPPINCOTT WILLIAMS & WILKINS 25 (1) 11 - 6 0363-9762 2000/01 [Refereed]
   

  PURPOSE: When the cerebral metabolic rate of glucose (CMRglc) is to be measured, arterial blood sampling is usually required for fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET) studies. However, blood sampling is inconvenient because it requires several staff members and is invasive for patients. METHODS: To assess cerebral glucose metabolism by a noninvasive and simplified method, the authors used the standardized uptake value (SUV), which requires no input function or blood sampling. The study participants included 18 healthy volunteers (4 men and 14 women; mean +/- SD age, 68.2+/-6.3 years), 18 patients with mild Alzheimer's disease (AD) (4 men and 14 women; mean +/- SD age, 68.8+/-7.3 years), and 18 patients with moderate AD (5 men and 13 women, mean +/- SD age, 69.5+/-8.5 years). Regional CMRglc and regional cerebral SUV were measured in the three groups using FDG PET, and the correlation between global CMRglc and global SUV was estimated. RESULTS: The correlation coefficients of global CMRglc and global SUV in the healthy volunteers, mild AD patients, and moderate AD patients were 0.82, 0.67, and 0.62, respectively. Compared with the healthy persons, the patients with mild AD showed significantly decreased CMRglc in the temporal, frontal, and parietal cortices, but they did not show significantly decreased SUV in any region. Patients with moderate AD had significantly decreased CMRglc in the temporal, frontal, occipital, parietal, and sensorimotor cortices and significantly decreased SUV in the temporal, frontal, occipital, and parietal cortices. CONCLUSION: The SUV would be useful as a semiquantitative index of cerebral glucose metabolism only in healthy persons or those with mild AD.
• Low cerebral glucose extraction rates in the human medial temporal cortex and cerebellum

  S Sakamoto; K Ishii

  JOURNAL OF THE NEUROLOGICAL SCIENCES ELSEVIER SCIENCE BV 172 (1) 41 - 48 0022-510X 2000/01 [Refereed]
   

  Previous studies have reported that there exist different regional sensitivities to acute hypoxia. To better understand these differences, we estimated regional differences of cerebral blood flow (CBF), cerebral glucose metabolism (CMRglc) and kinetic constants (K-1, k(2), k(3)) in the human cortex under resting conditions. CBF, CMRglc, kinetic rate constants and glucose extraction rate (GER) were measured in eight normal male subjects (mean age: 26.1+/- 4.9 years) using the O-15-water autoradiographic technique and subsequently the dynamic and the static [F-18]2-fluoro-2-deoxy-D-glucose technique with positron emission tomography (PET). Of all the brain structures investigated, the medial temporal lobe showed the lowest CBF (46.0 ml/100 g/min) and lowest CMRglc (3.97 mg/100 g/min). The medial temporal GER was lowest (8.9%), followed by the cerebellar GER (9.3%). While the cerebellar blood flow (64.0 ml/100 g/min) was the highest, the cerebellar metabolic rate for glucose (5.79 mg/100 g/min) was relatively low. The cerebellum showed the highest K-1 value (0.13) and k(2) value (0.16), and the lowest k(3) value (0.05), In the medial temporal cortices and cerebellum, CMRglc and GER were lower than those in the neocortices. These results indicate that there are great perfusional/metabolic differences between the medial temporal lobe, cerebellum and other brain regions in the normal human brain under resting conditions. (C) 2000 Elsevier Science B.V. All rights reserved.
• Features of regional cerebral glucose metabolism abnormality in corticobasal degeneration

  Nobutsugu Hirono; Kazunari Ishii; Masahiro Sasaki; Hajime Kitagaki; Mamoru Hashimoto; Toru Imamura; Satoshi Tanimukai; Tokiji Hanihara; Hiroaki Kazui; Etsuro Mori

  Dementia and Geriatric Cognitive Disorders S. Karger AG 11 (3) 139 - 146 1420-8008 2000 

  We studied regional cerebral glucose metabolism in 15 patients with a clinical diagnosis of corticobasal degeneration (CBD), 15 patients with probable Alzheimer's disease (AD), and 15 healthy controls for 19 brain regions. Asymmetry in regional glucose metabolism was found in the central and frontal cortices in patients with CBD as compared with either the normal controls or the patients with AD. Regional glucose metabolism in CBD patients was significantly lower in the paracentral and superior parietal areas and thalamus than in patients with AD. Relative glucose metabolism in patients with CBD was significantly higher in the posterior cingulate, medial temporal and basal frontal areas, and significantly lower in the paracentral and superior parietal areas than in those with AD. These features of regional glucose metabolic abnormality in CBD may correspond to neurological and cognitive disturbances peculiar to CBD. Copyright (C) 2000 S. Karger AG, Basel.
• Role of functional brain imaging in the evaluation of vascular dementia

  E Mori; K Ishii; M Hashimoto; T Imamura; N Hirono; H Kitagaki

  ALZHEIMER DISEASE & ASSOCIATED DISORDERS LIPPINCOTT WILLIAMS & WILKINS 13 S91 - S101 0893-0341 1999/12 [Refereed]
   

  There are various types of underlying damage to tissue and vessels in vascular dementia, including (1) single or multiple infarcts that involve association and limbic cortices, (2) small subcortical infarcts disrupting cortico-subcortical circuits, and (3) white matter lesions. The clinical picture of vascular dementia varies, and the role of functional brain imaging of cerebral blood flow and metabolism would be expected to be different among subtypes of vascular dementia. The role and value of functional brain imaging is limited for cortical infarcts; it is very valuable in assessing the impact on cortical function for small subcortical infarcts; and it is probably useful for evaluating white matter lesions, but this needs to be determined in further studies. At least in research of vascular dementia, functional brain imaging criteria should be included for proper patient selection. Careful studies using functional imaging tools in a well-characterized patient population will be needed.
• Distinctive neurobehavioral features among neurodegenerative dementias

  Nobutsugu Hirono; Etsuro Mori; Satoshi Tanimukai; Hiroaki Kazui; Mamoru Hashimoto; Tokiji Hanihara; Toru Imamura

  Journal of Neuropsychiatry and Clinical Neurosciences 11 (4) 498 - 503 0895-0172 1999/09 

  The distinctive neuropsychiatric features of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD) were investigated by using the Neuropsychiatric Inventory. The patients with FTD had significantly more euphoria, aberrant motor activity, and disinhibition and significantly fewer delusions compared with the patients with AD or DLB. The patients with DLB had significantly more hallucinations compared with the AD or FTD patients. The findings clearly demonstrate that AD, DLB, and FTD have distinctive neuropsychiatric features, which may correspond to different patterns of cerebral involvement characteristic of these three major degenerative dementias.
• Tc-99m ethyl cysteinate dimer SPECT and 2-[F-18]fluoro-2-deoxy-D-glucose PET in Alzheimer's disease. Comparison of perfusion and metabolic patterns.

  K Ishii; M Sasaki; S Sakamoto; S Yamaji; H Kitagaki; E Mori

  Clinical nuclear medicine LIPPINCOTT WILLIAMS & WILKINS 24 (8) 572 - 5 0363-9762 1999/08 [Refereed]
   

  PURPOSE: This study compared Tc-99m ethyl cysteinate dimer (ECD) SPECT images with 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) PET images in the same patients with Alzheimer's disease and determined whether ECD SPECT is as useful as FDG PET clinically. METHODS: Ten patients with probable Alzheimer's disease (mean +/- SD: age, 71 +/- 5.2 years; 6 women and 4 men; Mini-Mental State Examination score, 19.2 +/- 5.3) were evaluated in this study. Both ECD SPECT and FDG PET were performed within 1.5 months in each patient. RESULTS: ECD SPECT showed a reduction in parieto-temporal perfusion in 8 of the 10 patients, whereas FDG PET showed a reduction in temporoparietal metabolism in 9. The ECD images showed greater radiotracer uptake in the cerebellum and occipital lobe than did FDG images. The contrast between the radiotracer uptake in the sensorimotor area and that in the parietotemporal region was not as great in the ECD images as it was in the FDG images. CONCLUSION: Although ECD SPECT may not be superior to FDG PET, it is useful for the clinical evaluation of patients with Alzheimer's disease.
• Regional cerebral glucose metabolism and blood flow in a patient with Marchiafava-Bignami disease.

  K Ishii; Y Ikerjiri; M Sasaki; H Kitagaki; E Mori

  AJNR. American journal of neuroradiology AMER SOC NEURORADIOLOGY 20 (7) 1249 - 51 0195-6108 1999/08 [Refereed]
   

  We report functional neuroimaging studies of a 54-year-old man with Marchiafava-Bignami disease (MBD). Glucose metabolic images obtained by [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography showed diffusely reduced whole brain metabolism and strongly decreased metabolism in the frontal and parietal lobes, orbital gyrus, and thalamus. Cerebral perfusion images showed a similarly decreased radioactivity pattern as the metabolic images. Functional neuroimages would be useful for understanding the pathophysiologic processes of MBD.
• Regional cerebral blood flow difference between dementia with Lewy bodies and AD.

  K Ishii; S Yamaji; H Kitagaki; T Imamura; N Hirono; E Mori

  Neurology LIPPINCOTT WILLIAMS & WILKINS 53 (2) 413 - 6 0028-3878 1999/07 [Refereed]
   

  The authors studied 14 patients with dementia with Lewy bodies (DLB), 14 patients with AD, and 14 healthy control subjects with N-isopropyl-p-[123I]iodoamphetamine SPECT. Comparison with the statistical parametric mappings revealed that relative cerebral blood flow was lower in the occipital lobes and higher in the right medial temporal lobe in the DLB group than in the AD group. Decreased occipital perfusion and relatively well preserved medial temporal perfusion are features that distinguish DLB from AD.
• Visual hallucinations and regional cerebral metabolism in dementia with Lewy bodies (DLB).

  T Imamura; K Ishii; N Hirono; M Hashimoto; S Tanimukai; H Kazuai; T Hanihara; M Sasaki; E Mori

  Neuroreport LIPPINCOTT WILLIAMS & WILKINS 10 (9) 1903 - 7 0959-4965 1999/06 [Refereed]
   

  To investigate the neurobiological bases of visual hallucinations in dementia with Lewy bodies (DLB), regional cerebral glucose metabolism was compared among three patient groups; DLB with visual hallucinations, DLB without visual hallucinations and Alzheimer's disease (AD) without visual hallucinations. The regional metabolism was significantly lower in both DLB groups than in the AD group in the primary visual area and the posterior temporal, parietal and lateral occipital association areas. The hypometabolism in the right posterior temporal and parietal areas was significantly milder in DLB with visual hallucinations than in DLB without hallucinations. The hypometabolism in the primary visual cortex and the relatively preserved metabolism in the right temporoparietal association cortices may be associated with the occurrence of visual hallucinations in DLB patients.
• Hereditary sensory neuropathy with deafness and dementia: a clinical and neuroimaging study.

  K Hojo; T Imamura; M Takanashi; K Ishii; M Sasaki; S Imura; R Ozono; Y Takatsuki; S Takauchi; E Mori

  European journal of neurology Lippincott Williams and Wilkins 6 (3) 357 - 61 1351-5101 1999/05 [Refereed]
   

  We describe three sibling patients with autosomal dominantly inherited sensory neuropathy, sensorineural hearing loss and dementia. The features of cognitive-behavioral deficits in the patients, including executive dysfunction, apathy, indifference and inattention, were consistent with a frontal lobe dysfunction. Magnetic resonance imaging showed a diffuse brain atrophy. A fluorodeoxyglucose positron emission tomography in one patient and a single photon emission computed tomography in another demonstrated a glucose hypometabolism or a hypoperfusion in the medial frontal and thalamic regions. Primary frontal involvement or frontal dysfunction secondary to thalamic lesions may contribute to the nature of dementia in these patients.
• Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease

  Nobutsugu Hirono; Etsuro Mori; Minoru Yasuda; Toru Imamura; Tatsuo Shimomura; Mamoru Hashimoto; Satoshi Tanimukai; Hiroaki Kazui; Hikari Yamashita

  Journal of Neuropsychiatry and Clinical Neurosciences American Psychiatric Publishing Inc. 11 (1) 66 - 70 0895-0172 1999 

  The association between the apolipoprotein E epsilon 4 (APOE E4) allele and a wide spectrum of behavioral symptoms of Alzheimer's disease (AD) was investigated. Neither the severity nor the presence of any behavioural changes was associated with the number of APOE E4 alleles, even after controlling for the effects of age at onset, sex, education level, duration of illness, and severity of the dementia. The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele.
• Glucose metabolism evaluated by positron emission tomography in Lafora disease

  Zenichiro Kato; Kanji Yasuda; Kazunari Ishii; Hajime Takagi; Shinji Mizuno; Nobuyuki Shimozawa; Naomi Kondo

  Pediatrics International 41 (6) 689 - 692 1328-8067 1999 [Refereed]
  
• Lack of association of apolipoprotein E epsilon4 allele dose with cerebral glucose metabolism in Alzheimer disease.

  N Hirono; E Mori; M Yasuda; K Ishii; Y Ikejiri; T Imamura; T Shimomura; M Hashimoto; H Yamashita; M Sasaki

  Alzheimer disease and associated disorders LIPPINCOTT WILLIAMS & WILKINS 12 (4) 362 - 7 0893-0341 1998/12 [Refereed]
   

  Parietal cerebral glucose metabolism is reduced before substantial impairments appeared in subjects carrying the apolipoprotein E (APOE) epsilon4 allele, but the effect of the APOE epsilon4 allele on cerebral metabolism in Alzheimer disease (AD) is still undetermined. To investigate the effect of the APOE epsilon4 allele on cerebral metabolism in AD, we examined regional cerebral glucose metabolism in 83 patients with AD by using 18F-fluorodeoxyglucose and positron emission tomography. Cerebral glucose metabolism in the fronto-parieto-temporal association and limbic cortices was significantly decreased in the AD patients compared with 26 age- and sex-matched normal controls. Regional cerebral glucose metabolic rate was not correlated significantly with the number of APOE epsilon4 alleles in any region, which was consistent even after controlling the effects of age, sex, and severity of dementia, and in a subgroup analysis of those aged between 60 and 75. These results supported the view that the APOE epsilon4 allele is not associated with specific deficits in brain metabolism in AD despite evidence of preclinical alterations.
• Regional metabolism: associations with dyscalculia in Alzheimer's disease.

  N Hirono; E Mori; K Ishii; T Imamura; T Shimomura; S Tanimukai; H Kazui; M Hashimoto; H Yamashita; M Sasaki

  Journal of neurology, neurosurgery, and psychiatry BMJ Publishing Group 65 (6) 913 - 6 0022-3050 1998/12 [Refereed]
   

  OBJECTIVES: The ability to calculate, which is an important aspect of social daily living, is commonly impaired in patients with Alzheimer's disease even early in the course of the disease. Dyscalculia is often accompanied by focal brain damage, and has been argued to be an independent sign localised around the left temporoparietal region. However, the region most responsible for dyscalculia in Alzheimer's disease has not been determined. The relation between calculation ability and regional cerebral glucose metabolism in Alzheimer's disease was therefore examined. METHODS: The calculation ability, In 91 patients with probable Alzheimer's disease of minimal to moderate severity, was assessed using the arithmetic subtest of the Wechsler adult intelligence scale-revised and the performance correlated with regional cerebral glucose metabolism determined by "F-fluorodeoxyglucose and PET. RESULTS: Regional glucose metabolism in the left inferior parietal lobule and in the left inferior temporal gyrus was significantly correlated with the calculation performance irrespective of age, sex, education, and severity of disease. CONCLUSIONS: The results suggest that dysfunction of the left inferior parietal lobule and the left inferior temporal gyrus plays an important part in producing dyscalculia in patients with Alzheimer's disease.
• Relatively preserved hippocampal glucose metabolism in mild Alzheimer's disease

  K Ishii; M Sasaki; S Yamaji; S Sakamoto; H Kitagaki; E Mori

  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS KARGER 9 (6) 317 - 322 1420-8008 1998/11 [Refereed]
   

  The purpose of this study was to clarify the changes in hippocampal glucose metabolism in mild Alzheimer's disease (AD) using positron emission tomography (PET) and 2-(F-18)fluoro-2-deoxy-D-glucose (FDG). Forty-one patients with probable mild AD (age: 69.0 +/- 8.0 years; MMSE: 22.6 +/- 2.1) and 22 normal volunteers (age: 67.7 +/- 7.1 years) were studied. The regional cerebral metabolic rate for glucose (CMRglc) was measured using FDG and PET, Although the mean CMRglc in the parietal region was significantly lower in the AD group (right: 6.35 +/- 1.26 mg/100 g/min; left: 6.37 +/- 1.21 mg/100 gl min) than in the control group (right: 7.73 +/- 1.02 mg/100 g/min; left: 7.63 +/- 0.95 mg/100 g/min), the mean CMRglc in the hippocampus did not show a significant difference between the AD group (right: 4.58 +/- 0.70 mg/100 g/min; left: 4.63 +/- 0.67 mg/100 g/min) and the control group (right: 5.22 +/- 0.65 mg/100 g/min; left: 5.22 +/- 0.67 mg/100 g/min) by analysis of variance and post-hoc Tukey's test. The magnitude of the hippocampal CMRglc reduction was not as large as that of parietal CMRglc reduction. Statistical parametric maps (SPM) analysis also did not significantly demonstrate reduced hippocampal CMRglc in AD patients, although it did show a significant reduction in parietal CMRglc in AD patients. Hippocampal CMRglc was not significantly decreased in mild AD. This was unexpected in view of previous studies that have shown atrophy and clinical dysfunction concerning hippocampus in AD, and suggests that the pathophysiology of the hippocampus in AD may be more complex than was previously thought.
• Cerebral glucose metabolism in patients with frontotemporal dementia.

  K Ishii; S Sakamoto; M Sasaki; H Kitagaki; S Yamaji; M Hashimoto; T Imamura; T Shimomura; N Hirono; E Mori

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine SOC NUCLEAR MEDICINE INC 39 (11) 1875 - 8 0161-5505 1998/11 [Refereed]
   

  UNLABELLED: Frontotemporal dementia (FTD) is a dementia syndrome characterized by peculiar behavioral changes arising from frontotemporal involvement and distinct from Alzheimer's disease (AD). The purpose of this study was to elucidate the specific patterns in cerebral glucose metabolism in patients with FTD and to compare them with the patterns in patients with AD and normal elderly subjects using fluorodeoxyglucose (FDG) and PET. METHODS: Twenty-one patients with a clinical diagnosis of FTD [mean age 67.0 +/- 7.0 yr, Mini Mental State Examination (MMSE) score 18.7 +/- 5.7], 21 age-, sex- and dementia-severity-matched patients with probable AD (mean age 66.9 +/- 7.1 yr, MMSE score 20.2 +/- 5.5) and 21 age- and sex-matched normal control subjects (mean age 66.8 +/- 5.7 yr) were studied. The cerebral metabolic rate for glucose (CMRglc) was measured with FDG and PET. Absolute measures of regional CMRglc were compared among the three groups. One-way ANOVA and the posthoc Tukey HSD test were used for statistical analyses. RESULTS: In the FTD group, CMRglc was preserved only in the left cerebellum, right sensorimotor area and occipital lobes. The CMRglc was significantly lower in the FTD group as opposed to the AD group in the hippocampi, orbital gyri, anterior temporal lobes, anterior cingulate gyri, basal ganglia, thalami, middle and superior frontal gyri and left inferior frontal gyrus. CONCLUSION: Although metabolic abnormality in FTD is predominant in the frontal and anterior temporal lobes and the subcortical structures, it is more widespread than has been previously stressed. These findings document an FTD-specific cerebral involvement and facilitate differential diagnosis of degenerative dementias.
• CSF spaces in idiopathic normal pressure hydrocephalus: morphology and volumetry.

  H Kitagaki; E Mori; K Ishii; S Yamaji; N Hirono; T Imamura

  AJNR. American journal of neuroradiology AMER SOC NEURORADIOLOGY 19 (7) 1277 - 84 0195-6108 1998/08 [Refereed]
   

  PURPOSE: Idiopathic normal pressure hydrocephalus (NPH) is an important cause of dementia in the elderly; however, idiopathic NPH is often difficult to differentiate from normal aging and vascular dementias in which brain atrophy with ventricular dilatation (hydrocephalus ex vacuo or central atrophy) is present. To elucidate the distinctive features of the distribution of CSF in idiopathic NPH, we used MR imaging to investigate the morphologic features and volume of the CSF space in patients with idiopathic NPH compared with those with other dementias. METHODS: We assessed the size of four CSF compartments (the ventricle, basal cistern, sylvian space, and suprasylvian subarachnoid space) in 11 shunt-responsive patients with idiopathic NPH by semiquantitative and volumetric analyses of coronal T1-weighted MR images. The results were compared with those in 11 age- and sex-matched patients with Alzheimer disease and in 11 patients with vascular dementia. RESULTS: In patients with idiopathic NPH, the CSF volume was significantly increased in the ventricles and decreased in the superior convexity and medial subarachnoid spaces as compared with patients with other dementias. The sylvian CSF volume in patients with idiopathic NPH was significantly greater than in patients with Alzheimer disease. The volume of the basal cistern was comparable among the three groups. In several patients with idiopathic NPH, focally dilated sulci were observed over the convexity or medial surface of the hemisphere. CONCLUSION: Our results indicate that findings of enlarged basal cisterns and sylvian fissures and of focally dilated sulci support, rather than exclude, the diagnosis of shunt-responsive idiopathic NPH and suggest that this condition is caused by a suprasylvian subarachnoid block.
• Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease.

  K Ishii; T Imamura; M Sasaki; S Yamaji; S Sakamoto; H Kitagaki; M Hashimoto; N Hirono; T Shimomura; E Mori

  Neurology LIPPINCOTT WILLIAMS & WILKINS 51 (1) 125 - 30 0028-3878 1998/07 [Refereed]
   

  OBJECTIVE: To delineate the features of regional cerebral metabolic rate of glucose (CMRglc) in dementia with Lewy bodies (DLB). METHODS: We compared absolute CMRglc in 12 patients with a clinical diagnosis of DLB, 12 patients with a clinical diagnosis of Alzheimer's disease (AD), and 12 normal volunteers (NC), using 18F-fluorodeoxyglucose (FDG) and PET. The three groups were matched for age and sex, and there were no differences in disease duration or severity of cognitive disturbances between the DLB and AD groups. RESULTS: CMRglc was significantly lower in patients with DLB than in that of NC in most parts of the brain, except the sensorimotor cortices, basal ganglia, thalamus, and pons. Between the DLB and AD groups, there were significant regional CMRglc differences in the medial and lateral occipital lobes. In DLB and AD, the CMRglc reduction patterns were similar, though the global metabolic reduction was larger in DLB, and the occipital CMRglc reduction in DLB could differentiate DLB from AD. The relative occipital CMRglc (normalized to the sensorimotor CMRglc) was a useful measure for the differential diagnosis of DLB from AD. The sensitivity and the specificity were 92% when using the minimal value of the normalized occipital CMRglc in the NC group as the cut-off point. CONCLUSION: These different regional CMRglc reductions substantiate the pathologic, neurochemical, and clinical differences between DLB and AD.
• Bromocriptine treatment for perseveration in demented patients.

  T Imamura; M Takanashi; N Hattori; M Fujimori; H Yamashita; K Ishii; A Yamadori

  Alzheimer disease and associated disorders 12 (2) 109 - 13 0893-0341 1998/06 [Refereed]
   

  Some forms of behavioral perseveration may reflect the disruption of specific neurotransmitter systems including mesencephalic dopaminergic projection. We present an open-labeled trial of a dopamine agonist for treating perseveration in dementia. Eight patients with ischemic vascular or degenerative dementia completed a 25-day trial of bromocriptine with a maximum daily dose of 10 mg. Patients were assessed with neuropsychological scales and a test battery for detecting perseveration. Recurrent and stuck-in-set types of perseveration significantly improved during the treatment, whereas measures for general attention and overall cognitive function showed no significant changes. We assume that bromocriptine supplemented the mesolimbocortical or ventral mesostriatal dopamine system ameliorated a certain frontal lobe function such as focused attention or working memory and improved the patients' perseverations. Although this study is preliminary because of the small sample size and open-labeled design, the results underline the possibility of pharmacotherapy for perseveration and recommend a double-blind, placebo-controlled study.
• Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease.

  N Hirono; E Mori; K Ishii; Y Ikejiri; T Imamura; T Shimomura; M Hashimoto; H Yamashita; M Sasaki

  Journal of neurology, neurosurgery, and psychiatry BRITISH MED JOURNAL PUBL GROUP 64 (4) 552 - 4 0022-3050 1998/04 [Refereed]
   

  The relation between orientation for time and place and regional cerebral glucose metabolism was examined in 86 patients with probable Alzheimer's disease of minimal to moderate severity. Regional glucose metabolic rates in the posterior cingulate gyri and in the right middle temporal gyrus were significantly correlated with temporal orientation, and the glucose metabolic rate in the right posterior cingulate gyrus was significantly correlated with locational orientation irrespective of age, sex, education, and memory impairment. The results suggest that dysfunction of these structures plays an important part in producing disorientation in patients with Alzheimer's disease.
• Regional hypometabolism related to language disturbance in Alzheimer's disease

  N Hirono; E Mori; K Ishii; Y Ikejiri; T Imamura; T Shimomura; M Ikeda; H Yamashita; Y Takatsuki; M Sasaki

  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS KARGER 9 (2) 68 - 73 1420-8008 1998/03 [Refereed]
   

  To elucidate the nature of language disturbance in Alzheimer's disease (AD) and the cerebral area involved in it, we studied 65 AD patients with the Western Aphasia Battery (WAB) and with F-18-fluorodeoxyglucose and positron emission tomography. Partial correlations were evaluated between the Aphasia Quotient of WAB and regional cerebral glucose metabolism normalized by the mean metabolic rate in the bilateral primary sensorimotor areas after controlling age? sex, education and severity of illness. Language disturbance in AD is accounted for by deficits in the semantic processing of language and is related to glucose hypometabolism in the inferior temporal gyrus and inferior parietal lobule, especially in the dominant side. These results offer further evidence suggesting that the lexico-semantic processing system is mediated in these regions.
• Cerebral blood flow changes in the primary motor and premotor cortices during hyperventilation.

  K Ishii; M Sasaki; S Yamaji; S Sakamoto; K Maeda

  Annals of nuclear medicine Springer Tokyo 12 (1) 29 - 33 0914-7187 1998/02 [Refereed]
   

  The aim of this study was to clarify the regional differences in cerebral blood flow (CBF) change during hyperventilation by using H2(15)O and positron emission tomography (PET). Eight healthy volunteers (age: 63.0 +/- 8.9 yr.) were studied. Regional CBF was measured by the H2(15)O autoradiographic method and PET. Statistical parametric maps (SPM) and conventional regions of interest (ROI) analysis were used for estimating regional CBF differences in the normocapnic state with normal breathing and the hypocapnic state induced by hyperventilation. Total CBF decreased during the hypocapnic state. The SPM revealed that primary motor and premotor cortices were significantly activated by hyperventilation. In these areas absolute CBF values were significantly higher than those in the temporal, occipital and parietal lobes in the hypocapnic state, but there were no significant regional differences in the normocapnic state. In the hypocapnic state induced by hyperventilation, the primary motor and premotor CBF shows combined changes with vasoreaction to hypocapnia and increase in activation due to hyperventilation.
• Frontal lobe hypometabolism and depression in Alzheimer's disease.

  N Hirono; E Mori; K Ishii; Y Ikejiri; T Imamura; T Shimomura; M Hashimoto; H Yamashita; M Sasaki

  Neurology LIPPINCOTT WILLIAMS & WILKINS 50 (2) 380 - 3 0028-3878 1998/02 [Refereed]
   

  Depression is common in Alzheimer's disease (AD). Clinicoanatomic studies in focal brain injuries and functional imaging studies both in primary depression and in depression secondary to neurologic diseases have demonstrated involvement of the frontal lobe. Frontal involvement has not been established in the depression of AD. We studied the correlation between focal brain metabolic abnormalities and depression in AD. In 53 patients with probable AD of minimal to moderate disability, we assessed the severity of depression using the Neuropsychiatric Inventory and correlated the depression score with regional cerebral glucose metabolism determined by 18F-fluorodeoxyglucose and PET. Depression was present in 19 patients (36%). The depression score correlated significantly with normalized glucose metabolic rates in the bilateral superior frontal and left anterior cingulate cortices. These results indicated an association between depression and decreased activity in the frontal lobe in AD and support frontal involvement, especially in the left side, in depression, irrespective of disease etiology.
• Paradoxical hippocampus perfusion in mild-to-moderate Alzheimer's disease.

  K Ishii; M Sasaki; S Yamaji; S Sakamoto; H Kitagaki; E Mori

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine SOC NUCLEAR MEDICINE INC 39 (2) 293 - 8 0161-5505 1998/02 [Refereed]
   

  UNLABELLED: The purpose of this study was to clarify the changes in hippocampal perfusion in mild-to-moderate Alzheimer's disease using PET and (15)O-labeled water. METHODS: Sixteen patients with probable mild-to-moderate Alzheimer's disease (age: 68.1+/-11.3 yr; MMSE: 21.1+/-4.5) and 10 normal volunteers (age: 65.1+/-8.2 yr) were studied. Regional cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using (15)O-labeled water autoradiographic method, C(15)O-gas inhalation technique and PET. RESULTS: Although the mean CBF in the parietotemporal region was significantly lower in the patient group than in the control group, the mean CBF in the hippocampus did not show significant reduction between the two groups, both in absolute and relative values. There was no significant regional CBV difference between the two groups. Parietotemporal perfusion correlated well with cognitive scores, both in absolute and relative values, in Alzheimer's disease, but hippocampal perfusion did not correlate well. CONCLUSION: Hippocampal perfusion was preserved in mild-to-moderate Alzheimer's disease.
• Utility of automated hemispheric surface display of MRI in diagnosing for cortical atrophy

  H Kitagaki; E Mori; K Ishii; S Kobashi; Y Hata

  CAR '98 - COMPUTER ASSISTED RADIOLOGY AND SURGERY ELSEVIER SCIENCE BV 1165 76 - 81 0531-5131 1998 [Refereed]
  
• Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents

  Yoshiki Mino; Hajime Kitagaki; Masahiro Sasaki; Kazunari Ishii; Tetsuya Mori; Katsuki Yamada; Osamu Nagasawa

  Biological and Pharmaceutical Bulletin 21 (12) 1385 - 1388 0918-6158 1998 [Refereed]
   

  To find new contrast agents for magnetic resonance imaging (MRI), the spin-lattice relaxation time (T1)-reducing activities of metal complexes of EDTA, N-hydroxyethyethylenediamine-N,N',N'-triacetic acid (HEDTA), diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), deferoxamine, mugineic acid, and pectin with Fe(III) or Mn(II) were investigated. Strong activity was found in Fe(III)-deferoxamine, Fe(III)-mugineic acid, or Mn(II)- pectin. In the actual MRI tomogram, Fe(III)-deferoxamine exhibited a contrast-enhancing effect comparable with that of Gd(III)-DTPA, and a much stronger effect was observed for Mn(II)-pectin. Fe(III)-deferoxamine and the Mn(II)-pectin appear to be candidates, respectively, as a new intravenous contrast agent and an oral gas trointestinal one.
• Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease.

  N Hirono; E Mori; K Ishii; H Kitagaki; M Sasaki; Y Ikejiri; T Imamura; T Shimomura; M Ikeda; H Yamashita

  The Journal of neuropsychiatry and clinical neurosciences American Psychiatric Publishing Inc. 10 (4) 433 - 9 0895-0172 1998 [Refereed]
   

  The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.
• H2O-PET perfusion Z score image for a diagnosis of Alzheimer's disease

  K Ishii; E Mori; M Sasaki; H Kitagaki; S Hirano; Y Hata

  CAR '98 - COMPUTER ASSISTED RADIOLOGY AND SURGERY ELSEVIER SCIENCE BV 1165 863 - 863 0531-5131 1998 [Refereed]
  
• Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emission tomography.

  T Imamura; K Ishii; M Sasaki; H Kitagaki; S Yamaji; N Hirono; T Shimomura; M Hashimoto; S Tanimukai; H Kazui; E Mori

  Neuroscience letters ELSEVIER SCI IRELAND LTD 235 (1-2) 49 - 52 0304-3940 1997/10 [Refereed]
   

  Regional cerebral metabolic rate of glucose (rCMRglc) was studied in 19 patients with a clinical diagnosis of dementia with Lewy bodies (DLB) and 19 patients with a clinical diagnosis of Alzheimer's disease (AD), using [18F]fluorodeoxyglucose ([18F]FDG) and positron emission tomography (PET). The two groups were matched with age, gender, disease duration and severity of cognitive disturbances. In 'dementia with Lewy bodies' (DLB) patients, when compared with AD patients, significant rCMRglc decreases were distributed in the temporo-parieto-occipital association cortices and the cerebellar hemispheres. In contrast, the medial temporal and cingulate rCMRglc were significantly lower in AD patients than those in DLB patients. These different regional emphases of glucose hypometabolism are consistent with the pathological and neurochemical differences between DLB and AD and explain the different clinical features of the two diseases.
• Changes in cerebral blood flow and oxygen metabolism related to magnetic resonance imaging white matter hyperintensities in Alzheimer's disease.

  S Yamaji; K Ishii; M Sasaki; T Imamura; H Kitagaki; S Sakamoto; E Mori

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine SOC NUCLEAR MEDICINE INC 38 (9) 1471 - 4 0161-5505 1997/09 [Refereed]
   

  UNLABELLED: We studied changes in cerebral perfusion and oxygen metabolism to elucidate the pathophysiological nature and clinical significance of white matter hyperintensities in Alzheimer's disease (AD). METHODS: Sixteen AD patients (age 71.6 +/- 3.1 yr) whose T2-weighted MR images showed white matter hyperintensities, and 16 age-matched AD patients (age 71.0 +/- 4.3 yr) without white matter hyperintensities were compared. Regional cerebral blood flow (CBF), oxygen metabolism (CMRO2) and oxygen extraction fraction (OEF) were measured by using (15)O steady-state method and PET. RESULTS: There was no significant difference in cognitive impairment between the two groups. Compared to the patients without white matter hyperintensities, those with them had significantly low CBF values and significantly high OEF values in all cortical and white matter regions. However, there were no significant differences in CMRO2 values between the two groups. Severity of white matter hyperintensities correlated with the mean cortical and mean white matter OEF. CONCLUSION: In AD patients, white matter hyperintensities on T2-weighted MR images represent ischemic changes in which oxygen metabolism and function are fairly compensated. These changes are not disease-specific but are age-associated coincidences, as in normal aging with or without vascular risk factors.
• Gadolinium enhancement of the cerebrospinal fluid in a patient with meningeal fibrosis and cryptococcal infection.

  S Sakamoto; H Kitagaki; K Ishii; S Yamaji; Y Ikejiri; E Mori

  Neuroradiology SPRINGER VERLAG 39 (7) 504 - 5 0028-3940 1997/07 [Refereed]
   

  We describe the case of a 52-year-old man, with cryptococcal meningitis and meningeal fibrosis who had undergone ventricular shunting. Gd-DTPA-enhanced T1-weighted MRI revealed diffuse meningeal enhancement. Remarkably, there was enhancement of the pia mater and posterior fossa subarachnoid space.
• Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease.

  K Ishii; M Sasaki; H Kitagaki; S Yamaji; S Sakamoto; K Matsuda; E Mori

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine SOC NUCLEAR MEDICINE INC 38 (6) 925 - 8 0161-5505 1997/06 [Refereed]
   

  UNLABELLED: Although regional cerebral metabolism and blood flow in Alzheimer's disease (AD) have been studied extensively with PET and SPECT, few reports have been concerned with cerebellar metabolism or perfusion in Alzheimer's disease. To evaluate cerebellar glucose metabolism in Alzheimer's disease patients, we studied the cerebellar and cerebral metabolic rate for glucose (CMRglc) using 2[18F]fluoro-2-deoxy-D-glucose (18F-FDG) and PET. METHODS: Sixty-eight patients with Alzheimer's disease and 13 age-matched normal control subjects were examined. According to scores obtained on the Mini-Mental State Examination (MMSE), Alzheimer's disease patients were classified into three groups: severe (n = 9), moderate (n = 33) and mild (n = 26). RESULTS: The cerebellar glucose metabolism in the severe Alzheimer's disease group was significantly lower (cerebellar glucose metabolism: 5.71 +/- 0.62 mg/100 g/min) than that of the control group (6.85 +/- 0.66 mg/100 g/min), while temporal and parietal CMRglc were much more decreased. The cerebellar glucose metabolism in the mild and moderate Alzheimer's disease groups also showed lower levels than that of the control group, but the differences did not reach significant levels. Like other cortical CMRglc, the cerebellar glucose metabolism correlated with cognitive impairments. CONCLUSION: In severe Alzheimer's disease, cerebellar glucose metabolism is significantly reduced. The method of analysis using normalization of regional metabolic data to cerebellar values may be liable to err in severe Alzheimer's disease patients.
• Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography.

  K Ishii; M Sasaki; S Yamaji; S Sakamoto; H Kitagaki; E Mori

  European journal of nuclear medicine SPRINGER VERLAG 24 (6) 670 - 3 0340-6997 1997/06 [Refereed]
   

  Although decreased posterior cingulate metabolism in Alzheimer's disease (AD) has been previously reported, there have been no reports on posterior cingulate perfusion. In this study we evaluated posterior cingulate perfusion as a relative value using statistical parametric maps (SPMs) and as an absolute value using conventional region of interest (ROI) settings. Twenty-eight subjects, including 14 patients with mild AD (mean age: 66.4+/-12.1 years) and 14 normal controls (65.9+/-7.3 years) were studied. Regional cerebral blood flow (CBF) was measured with H215O and positron emission tomography (PET). In the SPM analysis, the left posterior cingulate and left parietotemporal CBFs were significantly decreased in the patients with mild AD (P<0.001). At a lower statistical threshold (P<0.05), the right posterior cingulate and right parietotemporal CBFs were also significantly decreased in the AD patients. In the ROI studies, the left parietal and posterior cingulate CBFs in the patients with mild AD were significantly lower than those of the normal controls by analysis of variance and post-hoc Scheffé's test (P<0.001). We conclude that posterior cingulate perfusion is decreased in mild AD, reflecting the pathological changes and metabolic reduction in the posterior cingulate gyrus that have previously been reported to occur in mild AD.
• Alteration of white matter MR signal intensity in frontotemporal dementia.

  H Kitagaki; E Mori; N Hirono; Y Ikejiri; K Ishii; T Imamura; M Ikeda; S Yamaji; H Yamashita; T Shimomura; Y Nakagawa

  AJNR. American journal of neuroradiology 18 (2) 367 - 78 0195-6108 1997/02 [Refereed]
   

  PURPOSE: To determine the diagnostic potential of MR imaging to show white matter involvement in frontotemporal dementia. METHODS: We evaluated MR signal intensity in cerebral white matter by visually inspecting and by quantitatively measuring signal intensity on MR images in 22 patients with frontotemporal dementia. The findings were compared with those in 22 age- and sex-matched patients who had had Alzheimer disease for the same length of time and with 16 age- and sex-matched healthy control subjects. RESULTS: Patients with frontotemporal dementia had a significant increase in white matter signal intensity in the frontal and/or temporal lobes on T2- and proton density-weighted images. Visual inspection of regular proton density-weighted images and measurements made on the T2- and proton density-weighted images were sensitive to changes in white matter signal. CONCLUSION: Increased MR signal intensity in the frontotemporal white matter on T2- and proton density-weighted MR images is a useful diagnostic sign of frontotemporal dementia and distinguishes this condition from Alzheimer disease.
• Regional cerebral blood flow and oxygen metabolism in a patient with Korsakoff syndrome.

  K Matsuda; S Yamaji; K Ishii; M Sasaki; S Sakamoto; H Kitagaki; T Imamura; E Mori

  Annals of nuclear medicine Springer Tokyo 11 (1) 33 - 5 0914-7187 1997/02 [Refereed]
   

  We report a functional neuroimaging study of a patient clinically diagnosed with Korsakoff syndrome. Positron emission tomography (PET) with the 15O inhalation method showed decreased regional cerebral blood flow (rCBF) and decreased regional cerebral metabolic ratio for oxygen (rCMRO2) in the bilateral fronto-temporal areas and in the left thalamus. These results suggest that dysfunction of the frontal-thalamic neural network plays a role in the disturbance of Korsakoff syndrome.
• Technetium-99m methoxyisobutylisonitrile single-photon emission tomography in hepatocellular carcinoma

  Kazuhito Fukushima; Michio Kono; Kazunari Ishii; Eiro Sakai; Shozo Hirota; Hidehisa Yuri

  European Journal of Nuclear Medicine 24 (11) 1426 - 1428 0340-6997 1997 [Refereed]
   

  Nine lesions in eight patients with hepatocellular carcinoma (HCC) were studied using single-photon emission tomography (SPET) and technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) to evaluate the pattern of uptake of 99mTc-MIBI in the lesions and the relation between the uptake pattern and the histopathology of HCC. All the lesions were diagnosed as HCC by per cutaneous needle biopsy. Four of the nine lesions showed positive uptake of 99mTc-MIBI, while the other five showed negative uptake. All of the lesions which showed positive uptake were of the compact type. Of the five lesions that showed negative uptake, four were of the trabecular type while one was of the compact type. These results suggest that the patterns of 99mTc-MIBI accumulation in HCC are divided into positive and negative types and that these uptake patterns are associated with the tissue structure of HCC.
• Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS.

  Y Ikejiri; E Mori; K Ishii; K Nishimoto; M Yasuda; M Sasaki

  Neurology LITTLE BROWN CO 47 (2) 583 - 5 0028-3878 1996/08 [Refereed]
   

  We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q10, increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET. The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS.
• Decreased medial temporal oxygen metabolism in Alzheimer's disease shown by PET.

  K Ishii; H Kitagaki; M Kono; E Mori

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine SOC NUCLEAR MEDICINE INC 37 (7) 1159 - 65 0161-5505 1996/07 [Refereed]
   

  UNLABELLED: In mild-to-moderate Alzheimer's disease, previous PET studies failed to reveal significant involvement in the medial temporal lobe having pathologically neurodegenerative changes. The purpose of this study was to clarify the medial temporal perfusion and functional changes in mild-to-moderate Alzheimer's disease using PET. METHODS: Sixteen patients with probable mild-to-moderate Alzheimer's disease (age 62.9 +/- 6.0 yr, MMSE 17.7 +/- 3.7) and 14 normal volunteers (age (60.9 +/- 5.9 yr) were studied. Regional cerebral blood flow (CBF), oxygen metabolism (CMRO2) and oxygen extraction fraction (OEF) were measured using 15O steady-state method and PET. By rendering magnetic resonance volumetry of the medial temporal structures, the significance of partial volume effects on PET study measurements was examined. RESULTS: The mean CMRO2 in the medial temporal, as well as in the parietal and lateral temporal cortices were significantly lower in the patient group than in the control group. The mean CBF in the parietal and lateral temporal cortices also significantly decreased in the patient group. The OEF in the medial temporal was also decreased in the Alzheimer's disease group, while the OEF in the other cortical regions in Alzheimer's disease group were similar to that of control group. Decline of medial temporal oxygen consumption was the most distinctive feature of Alzheimer's disease. Those measurements were independent from volume of medial temporal structures. In Alzheimer's disease, medial temporal CMRO2 and CBF correlated with some of the nonverbal memory test scores and cognitive impairment scales, when normalized for individual difference. CONCLUSION: Medial temporal oxygen metabolism was markedly affected in patients with mild-to-moderate Alzheimer's disease. This measure substantiated the functional impairment of the medial temporal region in Alzheimer's disease.
• Regional difference in cerebral blood flow and oxidative metabolism in human cortex.

  K Ishii; M Sasaki; H Kitagaki; S Sakamoto; S Yamaji; K Maeda

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine SOC NUCLEAR MEDICINE INC 37 (7) 1086 - 8 0161-5505 1996/07 [Refereed]
   

  UNLABELLED: We sought to determine if there are regional differences in cerebral blood flow (CBF) and cerebral metabolic ratio for oxygen (CMRO2) in normal subjects during the resting state. METHODS: Regional CBF, CMRO2 and oxygen extraction fraction (OEF) in 15 normal volunteers (mean age 58.8 +/- 8.2 yr) were measured during rest using PET and a 15O-gas steady-state technique. RESULTS: CBF and CMRO2 in the visual cortex were significantly higher than those in other cortices. Additionally, OEF in the sensorimotor cortex was significantly lower than that in other cortical regions. CONCLUSION: CBF and CMRO2 in the visual cortex are always high, and low OEF in the sensorimotor cortex exists even in resting state in normal subjects. We hypothesize that these regional functional differences would result in different resistances to degeneration.
• The clinical utility of visual evaluation of scintigraphic perfusion patterns for Alzheimer's disease using I-123 IMP SPECT.

  K Ishii; E Mori; H Kitagaki; S Sakamoto; S Yamaji; T Imamura; Y Ikejiri; M Kono

  Clinical nuclear medicine LIPPINCOTT-RAVEN PUBL 21 (2) 106 - 10 0363-9762 1996/02 [Refereed]
   

  The authors examined the role of SPECT perfusion pattern in the diagnosis of Alzheimer's disease (AD) using I-123 IMP. They studied 93 patients who had memory and cognitive disorders, including 42 patients with a diagnosis of probable AD, classifying SPECT images into determined perfusion patterns. The probability of AD was 54% with bilateral temporal and/or parietal defects, 69% with bilateral temporoparietal defects with additional defects, 17% with no defects, and 11% with frontal defects only. The sensitivity of bilateral temporoparietal perfusion defects for AD was 95.2%, whereas the specificity was 56.9%. In the absence of bilateral temporal and/or parietal defects on visual evaluation of SPECT, the diagnosis of AD was unlikely, although it is not pathognomonic for AD, because this sign would be seen in various neuropsychiatric diseases causing memory and cognitive impairments. Visual evaluation of SPECT is of value in the diagnosis of AD among patients with dementia.
• Interuncal Distance Measurements in Normal Controls and Patients with Dementia : MR Imaging Study

  ISHII Kazunari; KITAGAKI Hajime; SAKAMOTO Setsu; YAMAJI Shigeru; KONO Michio

  Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica (公社)日本医学放射線学会 55 (9) 646 - 650 0048-0428 1995/08 

  To evaluate the utility of measuring interuncal distance (IUD) as a reflection of the limbic system, we compared the IUD of 60 dementia patients with that of 10 normal controls. We also measured the width of the intracranial compartment (W1 and W2) to correct for differences in individual brain size, and calculated the ratio of IUD/W1 and IUD/W2. IUD could not separate patients with dementia from normal controls, but there were significant differences in IUD/W1 and IUD/W2 between patients with dementia and normal controls. IUD, IUD/W1 and IUD/W2 did not correlate with Mini-Mental Examination score or ADAS score in patients with dementia. We conclude that IUD measurement is not helpful in distinguishing patients with mild stage dementia from normal aged people or as a scale for dementia. However, we suggest that IUD/W1 and IUD/W2 can discriminate between cases of mild dementia and normal aged people.
• COMPARISON OF CARBON-DIOXIDE RESPONSIVENESS OF CEREBELLAR BLOOD-FLOW BETWEEN AFFECTED AND UNAFFECTED SIDES WITH CROSSED CEREBELLAR DIASCHISIS

  K ISHII; KANNO, I; K UEMURA; J HATAZAWA; T OKUDERA; A INUGAMI; T OGAWA; H FUJITA; E SHIMOSEGAWA

  STROKE AMER HEART ASSOC 25 (4) 826 - 830 0039-2499 1994/04 [Refereed]
   

  Background and Purpose Concerning vasoreactivity of cerebellar blood flow (CeBF) in patients affected with crossed cerebellar diaschisis (CCD), several controversies have been reported. One is reduced asymmetry of CeBF after acetazolamide administration in Tc-99m hexamethylpropyleneamine oxime single-photon emission-computed tomography, and the other is persistent asymmetry with alternation in PaCO2 using the Xe-133 clearance method. The purpose of this study is to examine whether CeBF vasoreactivity in the side affected with CCD is the same as that in the, unaffected side. Methods We analyzed CeBF during hypocapnia, normocapnia, and hypercapnia performed in 27 patients with cerebrovascular disease (age range, 38 to 73 years; mean age, 62.0 +/- 8.5 years) affected by CCD. CeBF was measured using (H2O)-O-15 and positron emission tomography. Results The CeBF ratio of CCD-affected side to CCD-unaffected side was consistent during the perturbation of PaCO2. This ratio was 0.82 +/- 0.08 for PaCO2 elevation and 0.83 +/- 0.07 for PaCO2 lowering. Both were not significantly different from unity. Conclusion The percent change of CeBF per millimeter of mercury PaCO2 change was uniform across affected and unaffected sides with CCD. These findings are consistent with our recent findings observed in activated cerebral tissue during photic stimulation.
• HIGH L-METHYL-[C-11]METHIONINE UPTAKE IN BRAIN-ABSCESS - A PET STUDY

  K ISHII; T OGAWA; J HATAZAWA; KANNO, I; A INUGAMI; H FUJITA; E SHIMOSEGAWA; M MURAKAMI; T OKUDERA; K UEMURA

  JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LIPPINCOTT-RAVEN PUBL 17 (4) 660 - 661 0363-8715 1993/07 [Refereed]
  
• Two cases of hepatobiliary scintigraphy of liver transplantation in rejection

  K. Kanegawa; S. Nishiyama; T. Muraji; K. Ishii; M. Kouno

  Kakuigaku 29 (4) 501 - 504 0022-7854 1992 [Refereed]
   

  We reported two patients with liver transplantation who are performed hepatobiliary scintigraphy in rejection. In one patient hepatobiliary scintigraphy shows dilatation of bile duct but it shows good clearance from liver. In another patient hepatobiliary scintigraphy shows delayed clearance from liver. Both patients recovered from rejection. There are four main complications-vascular and biliary abnormality, infection, rejection-after liver transplantation. Hepatobiliary scintigraphy shows almost same findings except biliary complication, so it is difficult to distinguish between infection and rejection. But hepatobiliary scintigraphy may be useful to evaluate transplantated liver function in rejection.
• Preparation of new 7-hydroxyguanine derivatives and their biological activities.

  M Kitahara; K Shinjyo; M Fukae; K Hosoe; T Shiraishi; K Ishii; K Watanabe; H Kawaharada

  The Journal of antibiotics 43 (4) 352 - 6 0021-8820 1990/04 [Refereed]
   

  We prepared new 7-hydroxyguanine derivatives, 7-hydroxyguanosine 5'-monophosphate and N2-tetrahydropyranyl-7-hydroxyguanine, and compared biological activities of 7-hydroxyguanine derivatives including nucleosides acquired previously. 7-Hydroxyguanine and its nucleotide inhibited the focus formation of Rous sarcoma virus. Antitumor activities of these derivatives against mouse leukemia L1210 were not so different from one another. Anti-proliferative activities of the derivatives on various human cell lines were significantly different from one another.
• MRI of mediastinal cavernous hemangioma.

  K Ishii; K Maeda; M Hashihira; Y Miyamoto; K Kanegawa; M Kusumoto; M Kono; S Nishiyama

  Pediatric radiology 20 (7) 556 - 7 0301-0449 1990 [Refereed]
   

  A cavernous hemangioma of the anterior mediastinum was studied by CT and MRI. CT did not give the diagnosis of the vascular tumor but MRI demonstrated the morphology of the vascular tumor. MRI is very useful for detecting a vascular tumor in the mediastinum.
• A case of tracheal agenesis

  K. Ishii; M. Hasegawa; T. Muraji; C. Tsugawa; K. Hashimoto; K. Kanegawa; S. Nishiyama; M. Kohno

  Japanese Journal of Clinical Radiology 34 (1) 161 - 163 0009-9252 1989 [Refereed]
  
• A case report of intralobar multifocal nephroblastomatosis

  K. Ishii

  Japanese Journal of Clinical Radiology 33 (8) 939 - 942 0009-9252 1988 [Refereed]
  
• A case of mesenchymal hamartoma of the liver

  K. Kanegawa; S. Nishiyama; M. Kono; H. Ito; K. Ishii; T. Tsugawa; K. Hashimoto; C. Sugimura

  Japanese Journal of Clinical Radiology 33 (9) 1035 - 1038 0009-9252 1988 [Refereed]
  

Books etc

• 症候学から見極める認知症

  石井一成 (Contributor認知症におけるPET画像診断up to date)新興医学出版社 2024/01
• Molecular Imaging of Neurodegenerative Disorders

  Kazunari Ishii (Contributor13. Semi-Quantitative Analysis: Software-Based Imaging Interpretation: NEUROSTAT/SPM)Springer 2023/08 9783031350979
• 胸部画像診断の勘ドコロNEO

  高橋, 雅士 (Contributor胸部病変とPET)メジカルビュー社 2023/01 9784758321037 xiii, 511p
• 画像診断ガイドライン

  日本医学放射線学会 (Contributorアルツハイマー病の診断においてMRIと脳血流SPECTは推奨されるか? pp 60-62.)金原出版 2021/09 9784307071239 536p
• 即戦力が身につく脳の画像診断

  三木 幸雄; 山田 惠 (Contributor脳脊髄液関連疾患 pp40,75,110,226,268)メディカル・サイエンス・インターナショナル 2021/04 9784815730147 xx, 527p
• よくわかる脳MRI

  青木 茂樹; 相田 典子; 井田 正博; 大場 洋 (ContributorLewy小体型認知症,認知症を伴うパーキンソン病. pp544-545, 特発性正常圧水頭症. pp562-563)学研メディカル秀潤社,学研プラス (発売) 2020/06 9784780909722 791p
• MRI of the brain

  細矢 貴亮; 興梠 征典; 三木 幸雄; 山田 惠 (Contributor脳脊髄液の循環動態とMRI.,pp749-752; 水頭症, pp753-761)メディカル・サイエンス・インターナショナル 2015/04 9784895928120 xx, 948p
• iNPH : idiopathic normal pressure hydrocephalus

  石川 正恒; 森 悦朗; 新井 一 (ContributorVIII 特発性正常圧水頭症の診断 8. MRI・CT所見. ｐp101-108)金芳堂 2014/10 9784765316170 viii, 209p
• 画像診断ガイドライン

  日本医学放射線学会; 日本放射線科専門医会・医会 (Contributorアルツハイマー病の診断にどのような画像検査を推奨するか？ pp 95-97, 特発性正常圧水頭症にはどのような画像検査が有用か？ pp 98-99)金原出版 2013/07 9784307070935 冊

Conference Activities & Talks

• Development of a specialized image reconstruction technique for dedicated breast positron emission tomography.  [Not invited]

  K. Hanaoka; S. Watanabe; D. Ishikawa-Morimoto; Y. Yamakawa; T. Kobayashi; A. Ohtani; S. Kumakawa; T. Ito; Y. Komoike; H. Kaida; K. Ishii

  EANM 2023 Congress  2023/09
• 生成系AIを用いた読影医によるアノテーション不要なFDG-PET/CT像の肺病変強調手法.  [Not invited]

  大谷和暉; 根本充貴; 甲斐田勇人; 瀬川 新; 木村裕一; 永岡 隆; 三上勝大; 山田誉大; 花岡宏平; 槌谷達也; 北島一宏; 石井一成

  第5回 日本核医学会近畿支部会  2023/07
• アミロイドPET撮像判断のための生成系AIによるFDG画像からのアミロイド画像合成の検討.  [Not invited]

  本田実沙; 山田誉大; 永岡 隆; 三上勝大; 根本充貴; 花岡宏平; 甲斐田勇人; 石井一成; 木村裕一

  第5回 日本核医学会近畿支部会  2023/07
• 乳房PET検査のための再構成手法.  [Not invited]

  花岡宏平; 石川大介; 山川善之; 小林哲哉; 大谷 篤; 熊川志帆; 位藤俊一; 菰池佳史; 山田誉大; 甲斐田勇人; 石井一成

  第5回 日本核医学会近畿支部会  2023/07
• Validation of a Glucose Metabolism to Tau Deposition Ratio Image in the Alzheimer’s Continuum.

  K. Ishii; T. Yamada; K. Hanaoka; H. Kaida; K. Ishii; T. Kato; A. Nakamura; BATON Study Group

  2023 SNMMI Annual Meeting  2023/06
• Initial study of an algorithm for estimating the presence of amyloid accumulation from 18F-FDG PET images using machine learning.  [Not invited]

  T. Yamada; K. Hanaoka; Hayato Kaida; K. Ishii

  Brain & BrainPET 2023  2023/06
• Acceleration Motion Compensation Diffusion-weighted Imaging For Aortitis: Phantom and Clinical Studies.  [Not invited]

  Hyodo T; Nozaki Y; Kaida H; Morimoto-Ishikawa D; Ueda Y; Ito M; Yasuda N; Fukushima H; Yamamoto A; Ishii K

  2022 RSNA  2022/11
• Quantitative Evaluation of Noncontrast Magnetic Resonance Enterography for Active Inflammation in Crohn's Disease Using Native T1 and T2 Mapping.  [Not invited]

  Morimoto-Ishikawa D; Hyodo T; Komeda Y; Fukushima H; Ito M; Ueda Y; Saito S; Ishii K

  2022 RSNA  2022/11
• 認知症診療における核医学検査の現状と将来展望 〜アミロイド・タウイメージングを中心に〜  [Invited]

  石井一成

  第30回 北海道脳PET・SPECT研究会  2022/11
• 地域在住高齢者における脳室・くも膜下腔脳脊髄液体積の加齢性変化とその臨床的意義.  [Not invited]

  日髙洋介; 橋本 衛; 末廣 聖; 福原竜治; 石川智久; 津野田尚子; 小山明日香; 本田和揮; 宮川雄介; 吉浦和宏; 朴 秀賢; 石井一成; 池田 学; 竹林 実

  第44回日本生物学的精神医学会年会、第32回日本臨床精神神経薬理学会年会、第52回日本神経精神薬理学会年会、第6回日本精神薬学会総会・学術集会の4学会合同年会  2022/11
• Fibrolamellar Hepatocellular Carcinomaの一例.  [Not invited]

  山田 穣; 浜川岳文; 藤谷哲也; 浦瀬篤史; 上月瞭平; 小寺 卓; 鈴木絢子; 平山 歩; 石田愛; 若林雄一; 関 紳一郎; 山田誉大; 松久保祐子; 任 誠雲; 兵頭朋子; 甲斐田勇人; 小塚健倫; 鶴﨑正勝; 石井一成

  第332回 日本医学放射線学会関西地方会  2022/10
• Study for detecting pulmonary nodules on FDG-PET/CT images with training small dataset.

  A. Segawa; M. Nemoto; H. Kaida, Y; Kimura; T. Nagaoka; H. Yamaguti; Y. Nakamae; T. Yamada; K. Hanaoka; K. Kitajima; T. Tsuchitani; K. Ishii

  The 13th Congress of the World Federation of Nuclear Medicine and Biology
• Evaluation on applicability of generative adversarial network to synthesize training images for AI-based computer aided diagnostic algorithm to dementia.

  A.Watanabe; T. Yamada; T. Nagaoka; M. Nemoto; H. Watabe; M. Ibaraki; K. Matsubara; K. Hanaoka; K. Ishii; Y. Kimura

  The 13th Congress of the World Federation of Nuclear Medicine and Biology
• Detection of Bone;Metastasis on;FDG-PET/CT Images using;Multi-step Anomaly Voxel Detection;Local Patch analysis with;Unsupervised Deep Features;Image Textures

  H. Yamaguchi; M. Nemoto; H. Kaida; Y. Kimura; T. Nagaoka; T. Yamada; K. Hanaoka; K. Kitajima; T. Tsuchitani; K. Ishii

  The 13th Congress of the World Federation of Nuclear Medicine and Biology
• Predicting the prognosis in tongue cancer patients using harmonized 18F-FDG PETCT parameters. A multicenter study.

  H. Kaida; K. Kitajima; T. Sekine; K. Ito; H. Daisaki; T. Kimura; A. Enomoto; N. Otsuki; K. Ishii

  The 13th Congress of the World Federation of Nuclear Medicine and Biology  2022/09
• アミロイドイメージングの現状と展望 〜臨床の立場から〜  [Invited]

  石井一成

  第42回 日本核医学技術学会総会学術大会  2022/09
• High performance dedicated Head PET scanner for Diagnosis of Dementia.

  Kazunari Ishii

  The 13th Congress of the World Federation of Nuclear Medicine and Biology  2022/09
• Amyloid PET imaging alone is not sufficient to diagnose dementia  [Invited]

  Kazunari Ishii

  The 13th Congress of the World Federation of Nuclear Medicine and Biology  2022/09
• Neuroimaging in dementia: Up-to-date.  [Invited]

  Kazunari Ishii

  The Asia Oceania Congress of Nuclear Medicine and Biology 2022  2022/09
• 急性膵炎後のWONに対する画像診断および経皮的ドレナージの役割.

  上月瞭平; 鶴﨑正勝; 浦瀬篤史; 小寺 卓; 平山 歩; 石井一成; 大本俊介; 竹中 完; 工藤正俊

  第58回 日本医学放射線学会秋季臨床大会
• 私とiNPH一過去・現在・未来一  [Invited]

  石井一成

  公開シンポジウム「特発性正常圧水頭症(iNPH)対策の課題と展望~治療で改善できる認知症へのフォーカス~」  2022/08
• 難治性直腸瘻に対する経皮的瘻孔閉鎖術

  鶴崎正勝; 小寺 卓; 上月瞭平; 浦瀬篤史; 平山 歩; 石井一成

  第7回 日本穿刺ドレナージ研究会  2022/07
• 肝内外の多発動脈-門脈瘻による門脈圧亢進症に対しIVRを施行した1例.

  浦瀬篤司; 鶴崎正勝; 小寺 卓; 上月瞭平; 平山 歩; 石井一成

  第71回 関西IVR研究会  2022/07
• 体幹部コイル塞栓術におけるAZUR soft 3Dの初期経験.

  小寺 卓; 鶴崎正勝; 上月瞭平; 浦瀬篤史; 平山 歩; 石井一成

  第71回 関西IVR研究会  2022/07
• FDG-PET/CT で集積を認めた膵臓アミロイドーシスの⼀例.

  甲斐田勇人; 山田 穣; 関 紳一郎; 松久保祐子; 任 誠雲; 花岡宏平; 山田誉大; 兵頭朋子; 鶴崎正勝; 細野 眞; 石井一成

  第4回 日本核医学会近畿支部会  2022/07
• 認知症診療における核医学検査の活用〜アミロイド・タウイメージングを含む最新の知見と展望〜  [Invited]

  石井一成

  長崎ニューロイメージングカンファレンス  2022/06
• Comparison of lesion detectability of dedicated breast PET and whole-body PET/CT.

  K. Hanaoka; S. Watanabe; D. Morimoto-Ishikawa; N. Ueno; A. Ohtani; Y. Yamakawa; S. Minagawa; T. Mizuta; H. Kaida; T. Itoh; Y. Komoike; K. Ishii

  SNMMI 2022 Annual Meeting
• Comparison between the μ-maps of different PET tracers: 18F-FDG and 18F-flutemetamol, generated by the attenuation correction method without external radiation source

  T. Yamada; K. Hanaoka; Y. Yamakawa; S. Minagawa; A. Ohtani; T. Mizuta; H. Kaida; K. Ishii

  SNMMI 2022 Annual Meeting
• Transcatheter coil embolization of splenic artery aneurysms: technique and midterm follow-up.

  M. Tsurusaki; I. Numoto; N. Ishida; A. Urase; R. Kozuki; T. Kotera; K. Ishii; T. Oda

  第51回 日本IVR学会総会  2022/06
• Robustness of a U-net model for different image processing types in segmentation of the mammary gland region.

  M. Yamamuro; Y. Asai; N. Hashimoto; N. Yasuda; H. Kimura; T. Yamada; M. Nemoto; Y. Kimura; H. Handa; H. Yoshida; K. Abe; M. Tada; H. Habe; T. Nakagawa; S. Nin; K. Ishii; Y. Lee

  16th International Workshop on Breast Imaging
• Acceleration Motion Compensation Diffusion-weighted Imaging for Large Vessel Vasculitis: Phantom Model and Initial Clinical Experience.

  T. Hyodo; D. Morimoto-Ishikawa; H. Kaida; Y. Ueda; D. Tomita; A. Yamamoto; M. Itoh; N. Yasuda; H. Fukushima; Y. Nozaki; I. Matsumura; K. Ishii

  2022 ISMRM-ESMRMB & ISMRT
• Quantitative Evaluation of Crohn's Disease Using Native T1 Mapping: A Feasibility Study.

  D. Morimoto-Ishikawa; T. Hyodo; Y. Komeda; H. Fukushima; Y. Ueda; K. Miyagoshi; S. Saito; K. Ishii

  2022 ISMRM-ESMRMB & ISMRT
• Native T1 マッピングによる潰瘍性大腸炎の疾患活動性評価の初期検討.

  石川 大介; 兵頭 朋子; 米田 頼晃; 上田 優; 宮越 敬三; 齋藤 茂芳; 石井 一成

  第78回日本放射線技術学会総会学術大会
• 腹部 CT 画像内の肝臓領域抽出.

  伊福 錬; 阿部孝司; 波部 斉; 兵頭朋子; 石井一成

  第26回電子情報通信学会関西支部学生会研究発表講演会  2022/03
• 肝細胞がん治療効果判定のためのCT画像中の早期濃染領域検出.

  福田大海; 波部斉; 阿部孝司; 兵頭朋子; 石井一成

  情報処理学会 第84回全国大会  2022/03
• 認知症診療におけるアミロイドPETの役割.  [Invited]

  石井一成

  第51回日本神経放射線学会  2022/02
• 上下腹神経叢ブロックを用いた婦人科疾患に対するIVRの経験.

  石田奈緒子; 鶴崎正勝; 上月瞭平; 小寺 卓; 沼本勲男; 小田晃義; 石井 一成

  第70回関西INTERVENTIONAL RADIOLOGY研究会  2022/02
• 大型血管炎診断におけるMR拡散強調像の動き補正技術

  若菜みゆき; 兵頭朋子; 甲斐田勇人; 石井一成; 大介; 伊藤洵; 安田奈央; 福島弘之; 冨田大介; 山本敦弘; 野﨑祐史; 松村 到

  第330回 日本医学放射線学会関西地方会  2022/02
• 乳房専用PET装置で明瞭に描出することができた非浸潤性乳管癌症例.

  上野尚美; 花岡宏平; 渡邊翔太; 石川大介; 甲斐田勇人; 位藤俊一; 菰池佳史; 石井一成

  第31回 乳癌画像研究会  2022/02
• GANによるFDG画像からのアミロイド画像合成の可能性の検討

  山口拓起; 渡邉 綾; 山田誉大; 中前有香子; 永岡 隆; 根本充貴; 石井一成; 木村裕一

  第11回核医学画像解析研究会  2021/12
• Metastases to the extraocular muscles: MR features of institutional 16 cases and a systemic review of clinical features.

  Kashiwagi N; Miura A; Sakai M; Hyodo T; Matsuo C; Fujiwara M; Arisawa A; Ishii K; Tomiyama N

  107th Radiological Society of North America. 2021
• Evaluation of the dedicated breast PET imaging technique including axillary region.

  K. Hanaoka; S. Watanabe; D. Morimoto-Ishikawa; T. Mizuta; A. Otani; Y. Yamakawa; H. Kaida; Y. Komoike; K. Ishii

  SNMMI 2021 Annual Meeting
• Optimization of Standardized Uptake Value of Fluorodeoxyglucose for Cortical Extraction in dedicated brain PET System.  [Not invited]

  D. Morimoto-Ishikawa; K. Hanaoka; S. Watanabe; A. Otani; T. Mizuta; Y. Yamakawa; H. Kaida; K. Ishii

  SNMMI 2021 Annual Meeting
• pleural appendage（胸膜脂肪垂）の画像診断.

  松久保祐子,松木 充,若菜みゆき,鈴木絢子,浜川岳文,沼本勲男,小田晃義,門場智也,藤谷哲也,任 誠雲,兵頭朋子,甲斐田勇人,柳生行伸,小塚健倫,鶴﨑正勝,石井一成.

  第324回 日本医学放射線学会関西地方会  2020/02
• 卵巣顆粒膜細胞腫の再発・転移の画像診断.

  浜川岳文,松木 充,若菜みゆき,鈴木絢子,沼本勲男,小田晃義,門場智也,藤谷哲也,任 誠雲,松久保祐子,兵頭朋子,甲斐田勇人,柳生行伸,鶴﨑正勝,小塚健倫,石井一成, 松村謙臣, 大谷知之.

  第324回 日本医学放射線学会関西地方会  2020/02
• 認知症画像診断における統計解析の役割.

  石井一成

  第24回 ニューロイメージングカンファレンス  2020/02
• 知っておきたい頭部画像診断のポイント ~認知症の画像診断を中心に~  [Invited]

  石井一成

  第72回 なにわ臨床画像研究会  2020/01
• TAFRO症候群の1例  [Not invited]

  鈴木絢子; 沼本勲男; 松木 充; 小田晃義; 山田 穣; 兵頭朋子; 任 誠雲; 甲斐田勇人; 柳生行伸; 細川知紗; 小塚健倫; 柏木伸夫; 鶴﨑正勝; 今岡いずみ; 石井一成; 榎木英介; 村上卓道

  第31回日本腹部放射線学会  2017/06
• 十二指腸ブルンネル腺過誤腫の1例  [Not invited]

  小田晃義; 松木 充; 沼本勲男; 福井秀行; 任 誠雲; 兵頭朋子; 柳生行伸; 鶴﨑正勝; 今岡いずみ; 石井一成; 村上卓道

  第31回日本腹部放射線学会  2017/06
• 認知症診断における核医学検査の現状と将来展望  [Not invited]

  石井一成

  長崎ニューロイメージングカンファレンス  2017/06
• 認知症の画像診断〜最近の話題を含めて〜  [Not invited]

  石井一成

  第１回日本脳神経外科認知症学会学術総会  2017/06
• 軽度認知機能患者におけるFDG-PETによるAD移行予測能の検討  [Not invited]

  岡田佑介; 岩田香織; 加藤隆司; 木村泰之; 木澤 剛; 中村昭範; 服部英幸; 乾 好貴; 外山 宏; 石井一成; 石井賢二; 千田道雄; 伊藤健吾; 岩坪 威; J-ADNI Group

  第32回日本老年精神医学会  2017/06
• Prognostic impact of 18F-FDG PET parameters and molecular markers expression in resected non-small cell lung cancer patients  [Not invited]

  Kaida H; Azuma K; Kwahara A; Sadashima E; Hattori S; Akiba J; Rominger A; Rakamori S; Fujimoto K; Hosono M; Ishii K; Murakami R; Ishibashi M

  SNMMI 2017 Annual Meeting  2017/06
• Integrated FDG-PET/MRI for whole-body staging in patients with recurrent gynecological cancer  [Not invited]

  Kitajima K; Nogami M; Takahashi S; Ueno Y; Ebina Y; Kubo K; Tanaka U; Sofue K; Ishihara T; Wakabayashi Y; Ishii K; Sugimura K

  SNMMI 2017 Annual Meeting  2017/06
• 食道癌切除患者におけるFDG集積の予後検討  [Not invited]

  甲斐田勇人; 石井一成; 細川知紗; 柳生行伸; 任 誠雲; 兵頭朋子; 山田 穣; 細野 眞; 安田卓司; 村上卓道

  第76回日本医学放射線学会総会  2017/04
• 認知症診療における核医学検査の有用性  [Not invited]

  石井一成

  第4回富山脳機能画像カンファレンス  2017/03
• 脳脊髄液：正常圧水頭症の画像所見  [Not invited]

  石井一成

  第36回日本画像医学会  2017/02
• 転移性耳下腺腫瘍のCT MRI所見  [Not invited]

  柏木伸夫; 任 誠雲; 甲斐田勇人; 柳生行伸; 小塚建倫; 細川知紗; 松木 充; 鶴﨑正勝; 今岡いずみ; 細野 眞; 石井一成; 村上卓道

  第315回日本医学放射線学会関西地方会  2017/02
• 脳血流SPECT定性画像上のConvexity “APPArent” Hyperperfusion (CAPPAH) signがiNPHの診断に有用である  [Not invited]

  大道卓摩; 近藤正樹; 徳田隆彦; 小泉英貴; 松島成典; 栗山長門; 石井一成; 森 悦郎; 山田 惠; 水野敏樹

  第18回日本正常圧水頭症学会  2017/02
• Algorithm for reference region delineation for amyloid imaging using pattern recognition scheme and kinetics of administered Aβ probe－considering the number of clusters－  [Not invited]

  Yamada T; Kimura Y; Nagaoka T; Hosokawa C; Murakami T; Ishii K

  Human Amyloid Imaging Conference 2017  2017/01
• Noise reduction algorithm for amyloid imaging without loss of image resolution.  [Not invited]

  Kimura Y; Fujii K; Yamada T; Hosokawa C; Sakata M; Murakami T; Ishii K

  Human Amyloid Imaging Conference 2017  2017/01
• 認知症患者における線条体アミロイド沈着の検討  [Not invited]

  細川知紗; 石井一成; Sauerbeck J; Scheiwein F; 甲斐田勇人; 兵頭朋子; 山田 穣; 細野 眞; 花岡宏平; 村上卓道

  第56回日本核医学会学術総会  2016/11
• 非小細胞肺癌のFDG集積とGlut-1, pStat1, pStat3での予後因子の検討  [Not invited]

  甲斐田勇人; 東 公一; 河原明彦; 服部 聡; 藤本公則; 高森信三; 藤本公則; 高森信三; 石井一成; 村上卓道; 石橋正敏

  第56回日本核医学会学術総会  2016/11
• FDG-PET/CTを契機に発見された再発性多発軟骨炎の一例  [Not invited]

  甲斐田勇人; 石井一成; 細川知紗; 細野 眞; 村上卓道

  PETサマーセミナーin熊本  2016/08
• 日常診療における認知症画像診断  [Not invited]

  石井一成

  第25回 宮城県核医学研究会  2016/07
• 認知症の画像診断〜読影のコツと最近の話題  [Not invited]

  石井一成

  第35回 播淡画像研究会  2016/07
• 11C-PiB PET陽性認知症の線条体集積の有無の検討  [Not invited]

  細川知紗; 石井一成; Julia Sauerbeck; Franziska Scheiwein; 甲斐田勇人; 兵頭朋子; 山田 穣; 細野 眞; 花岡宏平; 村上卓道

  第49回日本核医学会近畿地方会  2016/07
• Delineation algorithm on reference region for amyloid imaging using a time history of radioactivity.  [Not invited]

  Kimura Y; Yamada T; Hosokawa C; Okada S; Nagaoka T; Ishii K

  SNMMI 2016 Annual Meeting  2016/06
• Amyloid imaging in Japan  [Not invited]

  Ishii K

  Affiliation Bi-Annual Meeting 2016  2016/06
• Pretherapeutic FDG heterogeneity in tumors can predict local control in oropharyngeal cancer patients undergoing intensity-modulated radiation therapy  [Not invited]

  Hanaoka K; Hosono M; Tatebe H; Ishikawa K; Monzen H; Ishii K; Nishimura Y

  SNMMI 2016 Annual Meeting  2016/06
• Cerebral glucose metabolic reduction patterns of PiB accumulation positive and negative cognitive disordered subjects  [Not invited]

  Hosokawa C; Ishii K; Kimura Y; Kaida Y; Wakabayashi Y; Hyodo T; Hosono M; Murakami T

  SNMMI 2016 Annual Meeting  2016/06
• 十二指腸リンパ節瘻を合併した膵結核の1例  [Not invited]

  渡口真史; 松木 充; 沼本勲男; 福井秀行; 若林雄一; 山川美帆; 任 誠雲; 兵頭朋子; 柳生行伸; 鶴崎正勝; 今岡いずみ; 石井一成; 田中利絵; 今井 元; 石川 原; 竹山宜典; 前西 修; 村上卓道

  第30回日本腹部放射線学会  2016/06
• 副腎結核の1例  [Not invited]

  沼本勲男; 松木 充; 渡口真史; 福井秀行; 若林雄一; 山川美帆; 任 誠雲; 兵頭朋子; 柳生行伸; 鶴﨑正勝; 今岡いずみ; 石井一成; 村上卓道

  第30回日本腹部放射線学会  2016/06
• 孤立性腹部内臓動脈解離のCT所見  [Not invited]

  福井秀行; 松木 充; 小田晃義; 沼本勲男; 日高正二朗; 任 誠雲; 兵頭朋子; 柳生行伸; 小塚健倫; 鶴﨑正勝; 今岡いずみ; 石井一成; 村上卓道

  第313回公益社団法人日本医学放射線学会関西地方会  2016/06
• Nuclear Medicine Techniques in Neurological Diseases: Alzheimer’s disease  [Not invited]

  Ishii K

  IAEA International Workshop  2016/05
• Increased Pittsburgh Compound B accumulation in the white matter of Alzheimer brain  [Not invited]

  Wakabayashi Y; Ishii K; Hosokawa C; Hyodo T; Kaida H; Yamada M; Yagyu Y; Tsurusaki M; Sugimura K; Murakamai T

  日本分子イメージング学会 第11回総会・学術集会  2016/05
• 認知症診断における機能画像(PET, SPECT)の限界と留意点  [Not invited]

  石井一成

  第17回 アルツハイマー病研究会学術シンポジウム  2016/04
• 転移性耳下腺腫瘍のCT,MRI所見  [Not invited]

  柏木伸夫; 日高正二朗; 福井秀行; 柳生行伸; 中西克之; 小塚健倫; 石井一成; 沼本勲男; 筑後孝章; 村上卓道

  第75回日本医学放射線学会総会  2016/04
• 認知障害の11C PiB PETでの線条体集積と脳糖代謝の相関  [Not invited]

  細川知紗; 石井一成; 木村雄一; 甲斐田勇人; 若林雄一; 兵頭朋子; 山田 穣; 小塚健倫; 細野 眞; 村上卓道

  第75回日本医学放射線学会総会  2016/04
• 脳血流SPECTのレビューと課題  [Not invited]

  石井一成

  第17回 日本正常圧水頭症学会  2016/03
• 神経核内封入体病の1例  [Not invited]

  沼本勲男; 松木 充; 福井秀行; 若林雄一; 日高正二朗; 渡口真史; 藤谷哲也; 山川美帆; 兵頭朋子; 山田 穣; 任 誠雲; 甲斐田勇人; 柳生行伸; 柏木伸夫; 細川知紗; 小塚健倫; 鶴﨑正勝; 今岡いずみ; 細野 眞; 石井一成; 村上卓道

  第312回日本医学放射線学会関西地方会  2016/02
• 上顎洞術後変化としての眼窩下管拡大  [Not invited]

  福井秀行; 柏木伸夫; 任 誠雲; 甲斐田勇人; 柳生行伸; 小塚健倫; 細川知紗; 熊野正士; 鶴﨑正勝; 松木 充; 今岡いずみ; 細野 眞; 石井一成; 村上卓道

  第35回日本画像医学会  2016/02
• 認知症の画像診断  [Not invited]

  石井一成

  第5回 北大阪AD Meeting  2016/01
• DRLの核医学分野のトピックス  [Not invited]

  石井一成

  第295回定例研究会  2016/01
• Bizarre parosteal osteochondromatous proliferation of the sternum  [Not invited]

  Fukui H; Kashiwagi N; Enoki E; Nakajima Y; Numoto I; Wakabayashi Y; Toguchi M; Asato N; Yamakawa M; Im S; Hyodo T; Yagyu Y; Kumano M; Tsurusaki M; Imaoka I; Matsuki M; Ishii K; Murakami T

  第27回日本骨軟部放射線研究会  2016/01
• Low Tube Voltage CT with Iterative Reconstruction for the Diagnosis of Hepatocellular Carcinoma? HCC?  [Not invited]

  村上 卓道; 岡田 真広; 高橋 洋人; 兵頭 朋子; 石井 一成

  99th Radiological Society of North America  2013/12  Chicago  99th Radiological Society of North America
  
• Aging Effect on Cerebral Blood Flow Measurements in Brain Perfusion Imaging with 3D Arterial Spin Labeling.  [Not invited]

  村上 卓道; 高橋 洋人; 石井 一成; 柏木 伸夫; 松木 充; 宮越 敬三

  99th Radiological Society of North America  2013/12  Chicago  99th Radiological Society of North America
  
• Applications of the Fast kVp Switching Dual Energy CT for Hepatopancreato-biliary Imaging.  [Not invited]

  兵頭 朋子; 村上 卓道; 岡田 真広; 鶴﨑 正勝; 石井 一成

  99th Radiological Society of North America  2013/12  Chicago  99th Radiological Society of North America
  
• 後縦隔に発生したectopic neural tissueの1例  [Not invited]

  村上 卓道; 朝戸 信行; 松木 充; 福井 秀行; 任 誠雲; 千葉 輝明; 高橋 洋人; 兵頭 朋子; 山田 穣; 栁生 行伸; 鶴﨑 正勝; 岡田 真広; 柏木 伸夫; 細川 知紗; 小塚 健倫; 今岡 いずみ; 足利 竜一朗; 石井 一成; 藤谷 哲也

  第305回日本医学放射線学会関西地方会  2013/11  大阪  第305回日本医学放射線学会関西地方会
  
• 頭部造影MRIにおけるBlack Blood (BB) CUBE, BB CUBE-FLAIR法の有用性：1.5T・MR装置での検討  [Not invited]

  任 誠雲; 村上 卓道; 足利 竜一朗; 柳生 行伸; 石井 一成; 日高 正二朗; 若山 哲也; 三好

  第41回日本磁気共鳴医学会大会  2013/09  徳島  第41回日本磁気共鳴医学会大会
  
• ASL-MR潅流画像によるAlzheimer's disease(AD)の診断においてBorderzonesignが与える影響  [Not invited]

  村上 卓道; 高橋 洋人; 石井 一成; 柏木 伸夫; 宮越 敬三; 足利 竜一朗; 松木 充

  徳島  2013/09  第41回日本磁気共鳴医学会大会  徳島
  
• 11C-PIB-PET SUV画像の視覚判定と定量評価  [Not invited]

  細川 知紗; 村上 卓道; 石井 一成; 木村 裕一; 兵頭 朋子; 細野 眞; 坂口 健太; 宇佐美 公男

  第46回日本核医学会近畿地方会  2013/07  大阪  第46回日本核医学会近畿地方会
  
• 後腹膜原発のlipomatous hemangiopericytomaの1例  [Not invited]

  朝戸 信行; 村上 卓道; 鶴崎 正勝; 日高 正二朗; 松久保 祐子; 兵頭 朋子; 柳生 行伸; 岡田 真広; 今岡 いずみ; 松木 充; 足利 竜一朗; 石井 一成

  第27回日本腹部放射線研究会  2013/06  宇都宮  第27回日本腹部放射線研究会
  
• 消化管病変を伴ったSchonlein-Henoch紫斑病の3例  [Not invited]

  日高 正二朗; 村上 卓道; 松木 充; 任 誠雲; 兵頭 朋子; 山田 穣; 柳生 行伸; 鶴崎 正勝; 岡田 真広; 柏木 伸夫; 細川 知紗; 小塚 健倫; 今岡 いずみ; 足利 竜一朗; 石井 一成

  第304回日本医学放射線学会関西地方会  2013/06  大阪  第304回日本医学放射線学会関西地方会
  
• F-18 FDG-PET/CT検査にて経過観察しえた原発性肝神経内分泌腫瘍の1例  [Not invited]

  兵頭 朋子; 村上 卓道; 松木 充; 岡田 真広; 柳生 行伸; 鶴崎 正勝; 足利 竜一朗; 井上 達夫; 木村 雅友; 石井 一成

  第27回日本腹部放射線研究会  2013/06  宇都宮  第27回日本腹部放射線研究会
  
• Quantitative assessment of liver fat with dual energy CT: comparison with MR spectroscopy  [Not invited]

  兵頭 朋子; 村上 卓道; 工藤 正俊; 岡田 真広; 矢田 典久; 前西 修; 石井 一成

  Computer Assisted Radiology and Surgery, 27th Intemational Congress and Exhibition  2013/06  ドイツ  Computer Assisted Radiology and Surgery, 27th Intemational Congress and Exhibition
  
• 3D Artlrial spin labelingによるアルツハイマー病の脳潅琉画像：SPECTとの比較  [Not invited]

  村上 卓道; 高橋 洋人; 石井 一成; 柏木 伸夫; 宮越 敬三; 花岡

  第72回日本医学放射線学会総会  2013/04  横浜  第72回日本医学放射線学会総会
  
• Dual-energy CTによる肝脂肪定量：ファントム実験によるsingle-energy CTおよびMRSとの比較  [Not invited]

  兵頭 朋子; 岡田 真広; 鶴崎 正勝; 足利 竜一朗; 石井 一成; 村上 卓道; 工藤 正幸

  第72回日本医学放射線学会総会  2013/04  横浜  第72回日本医学放射線学会総会
  
• Phantom study of liver fat quantification in dual-energy CT: comparison to single-energy CT and MR spectroscopy.  [Not invited]

  兵頭 朋子; 村上 卓道; 岡田 真広; 石井 一成; 工藤 正幸; 望月 輝一

  25th European Congress of Radiology  2013/03  Vienna  25th European Congress of Radiology
  
• アルコール性肝障害に合併した多血性肝過形成結節の検討～画像所見を中心に～  [Not invited]

  日高 正二朗; 村上 卓道; 鶴﨑 正勝; 兵頭 朋子; 任 誠雲; 栁生 行伸; 岡田 真広; 松木 充; 足利 竜一朗; 石井 一成

  第19回肝血流動態イメージ研究会  2013/01  東京  第19回肝血流動態イメージ研究会
  
• The Usefullness of Conventional MR imaging in Establishing the Daiagnosis of Submandibular Pleomorphic Adenoma  [Not invited]

  柏木 伸夫; 村上 卓道; 高橋 洋人; 前西 修; 石井 一成; 中西 克之

  98th Radiological Society of North America  2012/11  アメリカ  98th Radiological Society of North America
  
• Distinguishing Neurodegeneratice Dementia with MRI,FDG-PET,and PiB-PET  [Not invited]

  石井 一成; 村上 卓道; 兵頭 朋子; 高橋 洋人; 岡田 真広

  98th Radiological Society of North America  2012/11  アメリカ  98th Radiological Society of North America
  
• Brain Perfusion Imaging of Alzheimer’s Disease with 3D Arterial Spin Labeling:Comparison with Brain Perfusion SPECT  [Not invited]

  高橋 洋人; 村上 卓道; 石井 一成; 柏木 伸夫

  98th Radiological Society of North America  2012/11  アメリカ  98th Radiological Society of North America
  
• 腫瘤形成した慢性顎下腺炎のFDG-PET/CT所見  [Not invited]

  村上 卓道; 細川 知紗; 柏木 伸夫; 松久保 祐子; 山田 穣; 任 誠雲; 兵頭 朋子; 高橋 洋人; 栁生 行伸; 岡田 真広; 小塚 健倫; 今岡 いずみ; 鶴﨑 正勝; 松木 充; 足利 竜一朗; 細野 眞; 石井 一成

  第302回日本医学放射線学会関西地方会  2012/11  大阪  第302回日本医学放射線学会関西地方会
  
• 認知症における脳FDG-PET早期撮像の可能性について  [Not invited]

  兵頭 朋子; 石井 一成; 坂口 健太; 花岡 宏平; 宇佐美 公男; 島元 健次; 山添 譲; 山田 穣; 松木 充; 細野 眞; 村上 卓道

  第52回日本核医学会学術総会  2012/10  札幌  第52回日本核医学会学術総会
  
• EOB-MRI肝細胞相におけるFlip angle(FA)の変化がコントラスト特性に与える影響  [Not invited]

  西山 大輔; 村上 卓道; 岡田 真広; 香川 祐毅; 宮越 敬三; 兵頭 朋子; 高橋 洋人; 今岡 いずみ; 松木 充; 足利 竜一朗; 石井 一成; 若山 哲也

  第40回日本磁気共鳴医学会大会  2012/09  京都  第40回日本磁気共鳴医学会大会
  
• レビー小体型認知症の頭頂側頭連合野の代謝低下はアミロイド沈着によらない  [Not invited]

  石井 一成; 村上 卓道; 兵頭 朋子; 坂口 健太; 花岡 宏平; 宇佐美 公男; 島元 健次; 山添 譲; 山田 穣; 松木 充; 細野 眞

  第45回日本核医学会近畿地方会  2012/07  京都  第45回日本核医学会近畿地方会
  
• 肝血行動態解析によるソラフェニブ治療効果の早期予測-CT perfusionを用いて  [Not invited]

  兵頭 朋子; 村上 卓道; 岡田 真広; 香川 祐毅; 日高 正二朗; 任 誠雲; 栁生 行伸; 上嶋 一臣; 矢田 典久; 石井 一成; 工藤 正俊; 工藤 正幸

  第48回日本肝癌研究会  2012/07  石川  第48回日本肝癌研究会
  
• Dual energy CTを用いた肝脂肪の定量評価：ファントム実験と初期臨床経験  [Not invited]

  兵頭 朋子; 岡田 真広; 矢田 典久; 前西 修; 香川 祐毅; 任 誠雲; 柏木 伸夫; 栁生 行伸; 今岡 いずみ; 松木 充; 足利 竜一朗; 石井 一成; 工藤 正俊; 村上 卓道

  第71回近畿大学医学会学術講演会  2012/07  大阪  第71回近畿大学医学会学術講演会
  
• CT perfusionによる肝血行動態解析：sorafenib投与による背景肝血流の変化と肝細胞癌治療効果  [Not invited]

  兵頭 朋子; 村上 卓道; 岡田 真広; 香川 祐毅; 日高 正二朗; 栁生 行伸; 上嶋 一臣; 矢田 典久; 松木 充; 石井 一成; 工藤 正俊

  第12回関西肝血流動態イメージ研究会  2012/06  大阪  第12回関西肝血流動態イメージ研究会
  
• Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM)  [Not invited]

  石井 一成; 岡田 真広; 村上 卓道

  16th Workshops of Japanese-German Radiological Affiliation  2012/05  Munster  16th Workshops of Japanese-German Radiological Affiliation
  
• Imaging for liver fibrosis in patients with chronic liver disease: comparison between T1 mapping of Gd-EOB-DTPA enhanced MRI and US elastography  [Not invited]

  岡田 真広; 村上 卓道; 石井 一成

  16th Workshops of Japanese-German Radiological Affiliation  2012/05  Munster  16th Workshops of Japanese-German Radiological Affiliation
  
• Distinguishing Idiopathic Normal Pressure Hydrocephalus from Neurodegenerative Diseases: Diagnostic Criteria, Imaging Characteristics, and Avoidance of Pitfalls.  [Not invited]

  石井 一成; 柏木 伸夫; 村上 卓道; 塚部明大

  RSNA ? Education Exhibits 2011  2011/12  Chicago  RSNA ? Education Exhibits 2011
  
• 画像を使った認知症の診断  [Not invited]

  石井 一成; 村上 卓道

  市民公開講座：もしかして認知症？～気になりませんか、物忘れ～  2011/11  大阪  市民公開講座：もしかして認知症？～気になりませんか、物忘れ～
  
• CT Perfusionによる肝細胞癌の分子標的薬治療効果予測  [Not invited]

  兵頭 朋子; 香川 祐毅; 岡田 真広; 日高 正二朗; 柳生 行伸; 熊野 正士; 柏木 伸夫; 小塚 健倫; 今岡 いずみ; 足利 竜一朗; 石井 一成; 工藤 正俊; 北野 雅之; 上嶋 一臣; 井上 達夫; 矢田 典久; 村上 卓道; 工藤 正幸

  第2回大阪消化器画像・IVR研究会  2011/09  大阪  第2回大阪消化器画像・IVR研究会
  
• F-FDG PET/CT にてsuperscanを呈した腎癌骨転移の1例  [Not invited]

  兵頭 朋子; 石井 一成; 植村 天受; 村上 卓道; 阪本 祐一; 中村

  第44回日本核医学会近畿地方会  2011/07  兵庫  第44回日本核医学会近畿地方会
  
• CT perfusionを用いた肝細胞癌に対するソラフェニブの効果判定の検討  [Not invited]

  村上 卓道; 香川 祐毅; 岡田 真広; 兵頭 朋子; 日高 正二朗; 柳生 行伸; 熊野 正士; 柏木 伸夫; 小塚 健倫; 今岡 いずみ; 足利 竜一朗; 石井 一成; 工藤 正俊; 北野 雅之; 上嶋 一臣; 井上 達夫; 矢田 典久; 工藤 正幸

  第11回関西肝血流動態イメージ研究会  2011/07  第11回関西肝血流動態イメージ研究会
  
• Correlation between biliary and liver enhancement on Gd-EOB-DTPA enhanced MR  [Not invited]

  岡田 真広; 石井 一成; 村上 卓道

  The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting  2011/07  大阪  The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting
  
• Clinical impact of CT attenuation correction by SPECT/CT in brain perfusion images.  [Not invited]

  石井 一成; 花岡宏平; 村上 卓道

  2011 Annual Meeting of Society of Nuclear Medicine  2011/06  San Antonio  2011 Annual Meeting of Society of Nuclear Medicine
  
• Optimal parameter setting for hepatobiliary phase of Gd-EOB-DTPA enhanced liver MRI  [Not invited]

  岡田 真広; 石井 一成; 村上 卓道

  The 3rd Asian Congress of Abdominal Radiology (ACAR),  2011/05  Beijing  The 3rd Asian Congress of Abdominal Radiology (ACAR),
  
• Gd-EOB-DTPA造影MRI肝細胞相で低信号を呈する乏血性結節の多血化について  [Not invited]

  兵頭 朋子; 岡田 真広; 香川祐毅; 熊野 正士; 今岡 いずみ; 石井 一成; 村上 卓道; 小来田 幸世; 今井; 康陽; 堀 雅敏; 望月 輝一

  日本消化器学会近畿支部第94回例会  2011/02  大阪国際会議場，大阪  日本消化器学会近畿支部第94回例会
  
• 認知症の画像診断～アミロイドイメージングによる超早期診断を含めて～  [Not invited]

  石井 一成; 村上 卓道

  第1回南大阪の認知症診断・治療・連携を考える会  2011  大阪  第1回南大阪の認知症診断・治療・連携を考える会
  

MISC

• T1・T2マッピングを用いたクローン病の疾患活動性評価

  石川 大介; 兵頭 朋子; 米田 頼晃; 上田 優; 福島 弘之; 齋藤 茂芳; 石井 一成  日本放射線技術学会総会学術大会予稿集  79回-  202  -202  2023/03
• 画素異常検知と深層教師なし特徴抽出によるFDG-PET/CT像上がん骨転移検出

  山口明乃; 根本充貴; 甲斐田勇人; 甲斐田勇人; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成  日本生体医工学会大会プログラム・抄録集(Web)  61st-  2022
• 深層画像生成技術を用いたFDG-PET/CT像異常検知による病変強調

  瀬川新; 根本充貴; 甲斐田勇人; 甲斐田勇人; 山口明乃; 木村裕一; 永岡隆; 山田誉大; 北島一宏; 石井一成; 石井一成  日本生体医工学会大会プログラム・抄録集(Web)  61st-  2022
• Native T1マッピングによる潰瘍性大腸炎の疾患活動性評価の初期検討

  石川大介; 石川大介; 兵頭朋子; 米田頼晃; 上田優; 宮越敬三; 齋藤茂芳; 石井一成  日本放射線技術学会総会学術大会予稿集  78th-  2022
• Quantitative validation on PET image generator using CycleGAN for CAD to dementia

  渡邉綾; 山田誉大; 渡辺翔吾; 永岡隆; 根本充貴; 宮崎晃一; 花岡宏平; 甲斐田勇人; 甲斐田勇人; 石井一成; 石井一成; 木村裕一  日本生体医工学会大会プログラム・抄録集(Web)  60th-  2021
• Detection of bone metastasis on FDG-PET / CT image using cascade by two types of anomaly detections

  山口明乃; 根本充貴; 甲斐田勇人; 甲斐田勇人; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成  日本生体医工学会大会プログラム・抄録集(Web)  60th-  2021
• 2種類の異常検知を用いたFDG-PET/CT像上のがん骨転移病変自動検出

  山口明乃; 根本充貴; 甲斐田勇人; 甲斐田勇人; 木村裕一; 永岡隆; 山田誉大; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成  核医学(Web)  58-  (Supplement)  2021
• 敵対的生成ネットワークで合成したPET画像における定量性の検討

  渡邉綾; 木村裕一; 山田誉大; 渡辺翔吾; 永岡隆; 根本充貴; 宮崎晃一; 花岡宏平; 甲斐田勇人; 甲斐田勇人; 石井一成; 石井一成  核医学(Web)  58-  (Supplement)  2021
• A Method for Measuring the Curative Effects of Molecular Targeted Therapy for Hepatocellular Carcinoma Using CT Images

  JOHNSON Joejeff; 阿部孝司; 波部斉; 兵頭朋子; 石井一成  電気学会電子・情報・システム部門大会(Web)  2021-  2021
• Development of KindAI-COVID, a diagnostic support system for COVID pneumonia using CT images

  永岡隆; 小塚健倫; 根本充貴; 波部斉; 山田誉大; 吉田久; 木村裕一; 石井一成; 石井一成  日本生体医工学会大会プログラム・抄録集(Web)  60th-  2021
• Automatic detection of cervical and thoracic lesions on FDG-PET/CT by organ specific one-class SVMs

  A. Tanaka; M. Nemoto; H. Kaida; Y. Kimura; T. Nagaoka; T. Yamada; K. Ushifusa; K. Hanaoka; K. Kitajima; T. Tsuchitani; K. Ishii  International Journal of Computer Assisted Radiology and Surgery  15-  (S1)  208  -209  2020/06  [Refereed]
  
• 真性腸石のCT所見

  浜川 岳文; 松木 充; 鈴木 絢子; 沼本 勲男; 小田 晃義; 門場 智也; 細野 眞; 石井 一成  Japanese Journal of Radiology  38-  (Suppl.)  42  -42  2020/02
• 横行結腸に生じたバンドによる絞扼性イレウスの1例 横行結腸軸捻転との比較

  沼本 勲男; 松木 充; 土居 秀平; 鈴木 絢子; 小田 晃義; 門場 智也; 藤谷 哲也; 松久保 祐子; 山田 穣; 兵頭 朋子; 任 誠雲; 甲斐田 勇人; 柳生 行伸; 小塚 健倫; 柏木 伸夫; 鶴崎 正勝; 細野 眞; 石井 一成  Japanese Journal of Radiology  38-  (Suppl.)  42  -42  2020/02
• 梗塞性耳下腺腫瘍のMRI所見

  柏木 伸夫; 石井 一成; 小塚 健倫; 任 誠雲; 松木 充; 細野 眞  Japanese Journal of Radiology  38-  (Suppl.)  45  -45  2020/02
• One-class SVMを用いた病変強調によるFDG-PET/CT上の頸胸部病変の自動検出

  田中敦子; 根本充貴; 甲斐田勇人; 木村裕一; 永岡隆; 山田誉大; 牛房和之; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成  電子情報通信学会技術研究報告  119-  (399(MI2019 65-123)(Web))  2020
• 認知症自動診断AIアルゴリズム学習のための深層学習により加増したアミロイド画像の検証

  渡邉綾; 木村裕一; 山田誉大; 渡辺翔吾; 永岡隆; 根本充貴; 宮崎晃一; 花岡宏平; 甲斐田勇人; 甲斐田勇人; 石井一成; 石井一成  核医学(Web)  57-  (Supplement)  2020
• One-class SVMを用いた異常検知によるPET/CT上の骨転移病変自動検出

  田中敦子; 根本充貴; 甲斐田勇人; 甲斐田勇人; 木村裕一; 永岡隆; 牛房和之; 山田誉大; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成  核医学(Web)  57-  (Supplement)  2020
• Deep learningを用いた非高濃度乳房に対する乳腺領域の自動抽出

  山室美佳; 山室美佳; 浅井義行; 橋本直美; 安田奈生; 尾崎吉明; 任誠雲; 石井一成; 山田誉大; 根本充貴; 木村裕一; 吉田久; 半田久志; 李鎔範  日本乳癌検診学会学術総会プログラム抄録集  30th (CD-ROM)-  2020
• Deep learning segmentationでの複数の放射線技師による教師データ作成の有用性

  山室美佳; 山室美佳; 浅井義行; 橋本直美; 安田奈生; 尾崎吉明; 任誠雲; 石井一成; 山田誉大; 根本充貴; 木村祐一; 吉田久; 半田久志; 李鎔範  日本乳癌検診学会学術総会プログラム抄録集  30th (CD-ROM)-  2020
• 【認知症の画像診断〜ルーチン検査から最新の画像検査まで〜】特発性正常圧水頭症の画像診断

  宮崎 晃一; 石井 一成  Rad Fan  17-  (13)  35  -40  2019/10
• 【苦手克服!よくわかる膜・間隙の画像診断】肝膵脾領域にて膜・靱帯・間隙を意識した画像診断

  門場 智也; 松木 充; 若菜 みゆき; 鈴木 絢子; 浜川 岳文; 小田 晃義; 沼本 勲男; 松久保 祐子; 任 誠雲; 柳生 行伸; 小塚 健倫; 鶴崎 正勝; 石井 一成  画像診断  39-  (12)  1257  -1275  2019/09
• 経皮的ルートからの良性胆道狭窄に対するプラスチックステント留置術の初期経験

  小田 晃義; 鶴崎 正勝; 鈴木 絢子; 土居 秀平; 沼本 勲男; 門場 智也; 柳生 行伸; 柏木 伸夫; 石井 一成  日本インターベンショナルラジオロジー学会雑誌  34-  (1)  79  -79  2019/09
• 核医学によるてんかん画像診断

  石井 一成  てんかん研究  37-  (2)  473  -473  2019/09
• 肝細胞癌術後胆汁瘻に対し経皮的アプローチと内視鏡的アプローチを組み合わせてステント留置を施行した1例

  鈴木 絢子; 沼本 勲男; 鶴崎 正勝; 小田 晃義; 門場 智也; 柳生 行伸; 石井 一成; 岡本 彩那; 三長 孝輔; 岩崎 寿光  日本インターベンショナルラジオロジー学会雑誌  34-  (1)  79  -79  2019/09
• FDG-PET and amyloid PET for clinical diagnosis of dementia

  石井 一成  医学のあゆみ  270-  (9)  725  -731  2019/08
• Nuclear protein in testis(NUT)midline carcinomaの一例

  山田 穣; 柏木 伸夫; 土居 秀平; 沼本 勲男; 浜川 岳文; 門場 智也; 松久保 祐子; 兵頭 朋子; 甲斐田 勇人; 任 誠雲; 柳生 行伸; 小塚 健倫; 岡野 意浩; 坂田 尚己; 松木 充; 石井 一成  日本小児放射線学会雑誌  35-  (Suppl.)  28  -28  2019/06
• Evaluation of Robustness in Computer-Aided Diagnosis for Parkinsonian Syndromes Based on Machine Learning with Multi-center DaTSCAN SPECT Images

  渡辺 翔吾; 杉本 直三; 木村 裕一; 根本 充貴; 石井 一成; 三品 雅洋  システム制御情報学会研究発表講演会講演論文集  63-  453  -455  2019/05
• 肝細胞癌破裂症例の予後因子に関する臨床的検討

  鈴木 絢子; 鶴崎 正勝; 沼本 勲男; 小田 晃義; 門場 智也; 柳生 行伸; 石井 一成  日本インターベンショナルラジオロジー学会雑誌  34-  (Suppl.)  229  -229  2019/05
• iNPH Diagnostic imaging DESH

  石井 一成  Rad Fan  17-  (4)  5  -9  2019/03
• 認知症自動診断AIアルゴリズム学習のための深層学習によるアミロイド画像の加増手法の検討

  渡邉綾; 山田誉大; 永岡隆; 根本充貴; 花岡宏平; 甲斐田勇人; 石井一成; 石井一成; 木村裕一  核医学(Web)  56-  (Supplement)  2019
• AI異常検知に基づくPET/CT上の頸胸部病変の自動認識

  田中敦子; 根本充貴; 甲斐田勇人; 甲斐田勇人; 木村裕一; 山田誉大; 牛房和之; 花岡宏平; 北島一宏; 槌谷達也; 石井一成; 石井一成  核医学(Web)  56-  (Supplement)  2019
• FDG-PET/CTの統計的異常検知処理による転移を考慮した頸胸部病変の自動検出

  田中 敦子; 根本 充貴; 甲斐田 勇人; 木村 裕一; 永岡 隆; 山田 誉大; 花岡 宏平; 石井 一成  生体医工学  57-  (0)  S249_2  -S249_2  2019
• イメージングバイオマーカー(structural MRI,FDG‐PET,PiB PET)を用いた軽度認知障害からアルツハイマー型認知症への進展予測

  岡田佑介; 岡田佑介; 岩田香織; 加藤隆司; 木村泰之; 木澤剛; 中村昭範; 服部英幸; 乾好貴; 外山宏; 石井一成; 石井賢二; 千田道雄; 松田博史; 伊藤健吾; 岩坪威  核医学(Web)  55-  (1)  14(J‐STAGE)  -14  2018/12
• Morphologic imaging for mild cognitive impairment

  石井 一成  臨床精神医学  47-  (12)  1385  -1389  2018/12
• パーキンソン症候群に対するDAT Z-score画像の臨床応用

  高橋 竜一; 石井 一成; 樫林 哲雄; 丸本 浩平; 多々野 誠; 水田 英二  臨床神経学  58-  (Suppl.)  S213  -S213  2018/12
• イメージングバイオマーカー(structural MRI、FDG-PET、PiB PET)を用いた軽度認知障害からアルツハイマー型認知症への進展予測

  岡田 佑介; 岩田 香織; 加藤 隆司; 木村 泰之; 木澤 剛; 中村 昭範; 服部 英幸; 乾 好貴; 外山 宏; 石井 一成; 石井 賢二; 千田 道雄; 松田 博史; 伊藤 健吾; 岩坪 威  核医学  55-  (1)  14  -14  2018/12
• 胸骨圧迫による遅発性両側内胸動脈出血に対し、経カテーテル的動脈塞栓術を施行した1例

  鈴木 絢子; 鶴崎 正勝; 小田 晃義; 沼本 勲男; 門場 智也; 柳生 行伸; 土居 秀平; 柏木 伸夫; 石井 一成  IVR: Interventional Radiology  33-  (3)  315  -315  2018/11
• 肝門部胆管癌における胆道再建後の吻合部再発に対し胆管および門脈にステント留置術を行った2例

  門場 智也; 鶴崎 正勝; 小田 晃義; 沼本 勲男; 柳生 行伸; 柏木 伸夫; 石井 一成; 鎌田 研; 工藤 正俊  IVR: Interventional Radiology  33-  (3)  318  -318  2018/11
• PiB PETの境界的な集積に対応する皮質平均SUVRのカットオフ値の検討

  岡田 佑介; 岩田 香織; 加藤 隆司; 服部 英幸; 外山 宏; 石井 一成; 石井 賢二; 千田 道雄; 伊藤 健吾; 岩坪 威; Neuroimaging Initiative Japanese Alzheimer's Disease  核医学  55-  (Suppl.)  S169  -S169  2018/11
• 【認知症トータルケア】アルツハイマー型認知症のCT、MRI画像、脳血流SPECT、アミロイドPET

  石井 一成  日本医師会雑誌  147-  (特別2)  S4  -S6  2018/10
• 脳血流SPECT検査 (特集 鑑別診断に用いられる脳イメージング)

  高橋 竜一; 石井 一成  認知症の最新医療 : 認知症医療の今を伝える専門誌  8-  (4)  171  -176  2018/10
• 頭頸部扁平上皮癌からの骨転移

  鈴木 絢子; 柏木 伸夫; 沼本 勲男; 小田 晃義; 門場 智也; 兵頭 朋子; 山田 穣; 甲斐田 勇人; 柳生 行伸; 任 誠雲; 鶴崎 正勝; 小塚 健倫; 松木 充; 石井 一成; 中西 克之  日本医学放射線学会秋季臨床大会抄録集  54回-  S470  -S470  2018/09
• 真性腸石のCT所見

  浜川 岳文; 松木 充; 鈴木 絢子; 沼本 勲男; 小田 晃義; 門場 智也; 土居 秀平; 松久保 祐子; 兵頭 朋子; 任 誠雲; 甲斐田 勇人; 柳生 行伸; 鶴崎 正勝; 小塚 健倫; 石井 一成  日本医学放射線学会秋季臨床大会抄録集  54回-  S498  -S498  2018/09
• 非外傷性急性硬膜下血腫の画像診断

  沼本 勲男; 松木 充; 土居 秀平; 鈴木 絢子; 小田 晃義; 門場 智也; 松久保 裕子; 兵頭 朋子; 任 誠雲; 柏木 伸夫; 小塚 健倫; 鶴崎 正勝; 石井 一成  日本医学放射線学会秋季臨床大会抄録集  54回-  S502  -S503  2018/09
• 拡張した右下横隔膜動脈の破綻によって発症した血胸の1例

  小田 晃義; 松木 充; 鶴崎 正勝; 沼本 勲男; 門場 智也; 柳生 行信; 小塚 健倫; 石井 一成  日本医学放射線学会秋季臨床大会抄録集  54回-  S548  -S548  2018/09
• Diagnostic imaging for dementia : Difficulty of standardization

  石井 一成  老年精神医学雑誌  29-  (9)  931  -939  2018/09
• PiB PETの境界的な集積に対応する皮質平均SUVRのカットオフ値の検討

  岡田 佑介; 岩田 香織; 加藤 隆司; 木村 泰之; 中村 昭範; 服部 英幸; 外山 宏; 石井 一成; 石井 賢二; 千田 道雄; 伊藤 健吾; 岩坪 威  Dementia Japan  32-  (3)  470  -470  2018/09
• 脳内アミロイドβ蓄積を反映する血液バイオマーカー 多施設共同研究による精度の検討

  中村 昭範; 金子 直樹; 加藤 隆司; 石井 賢二; 石井 一成; 新畑 豊; 岩本 慎一; 伊藤 健吾; 田中 耕一; 柳澤 勝彦  Dementia Japan  32-  (3)  418  -418  2018/09
• バッドキアリ症候群に伴う急性肝不全に対して肝移植までのbridging therapyとしてTIPSを施行した一例

  沼本勲男; 鶴崎正勝; 鈴木絢子; 土居秀平; 小田晃義; 門馬智也; 柳生行伸; 石井一成; 上嶋一臣; 工藤正俊  日本門脈圧亢進症学会雑誌  24-  (3)  136  -136  2018/08
• バッドキアリ症候群に伴う急性肝不全に対して肝移植までのbridging therapyとしてTIPSを施行した一例

  沼本 勲男; 鶴崎 正勝; 鈴木 絢子; 土居 秀平; 小田 晃義; 門馬 智也; 柳生 行伸; 石井 一成; 上嶋 一臣; 工藤 正俊  日本門脈圧亢進症学会雑誌  24-  (3)  136  -136  2018/08
• 【画像診断医のための認知症画像診断】脳FDG-PET,アミロイドPET

  石井 一成  画像診断  38-  (9)  929  -937  2018/07
• Diagnostic Imaging for Dementia with Lewy Bodies

  石井 一成  近畿大学医学雑誌  43-  (1-2)  3  -10  2018/06
• 脳脊髄液 特発性正常圧水頭症の画像所見

  石井 一成  Japanese Journal of Diagnostic Imaging  36-  (1)  72  -72  2018/02
• 【脳脊髄液動態のすべて】特発性正常圧水頭症 画像所見と背景病理

  石井 一成  画像診断  38-  (3)  297  -304  2018/02
• 【認知症と画像診断-認知症の画像診断の役割と将来展望-】画像診断 FDG-PETの役割

  石井 一成  Rad Fan  16-  (3)  71  -73  2018/02
• Brain FDG-PET and perfusion SPECT for dementia

  石井 一成  臨床放射線  63-  (2)  151  -156  2018/02
• AI異常検知を用いたFDG-PET/CT上の頸胸部原発性・転移性病変の検出

  根本充貴; 甲斐田勇人; 田中敦子; 牛房和之; 山田誉大; 木村裕一; 花岡宏平; 石井一成; 石井一成  核医学(Web)  55-  (Supplement)  2018
• SRTM法を用いたアミロイドイメージングに対する空間分解能を損なわないノイズ低減アルゴリズムの検討

  山田誉大; 木村裕一; 根本充貴; 坂田宗之; 永岡隆; 花岡宏平; 甲斐田勇人; 石井一成; 石井一成  核医学(Web)  55-  (Supplement)  2018
• 【実施診療のための最新認知症学-検査・治療・予防・支援-】アルツハイマー病の先進医療とRegistry DIAN-J研究登録事業

  森 啓; 嶋田 裕之; 東海林 幹夫; 池内 健; 鈴木 一詩; 千田 道雄; 石井 賢二; 松田 博史; 岩田 敦; 井原 涼子; 岩坪 威; 武藤 香織; 中澤 栄輔; 関島 良樹; 森 悦朗; 池田 学; 池田 将樹; 川勝 忍; 中西 亜紀; 橋本 衛; 布村 明彦; 松原 悦朗; 福井 充; 白戸 朋代; 平井 香織; 坂本 昌子; 藤井 比佐子; 石井 一成; 西郷 和真  日本臨床  76-  (増刊1 実施診療のための最新認知症学 検査・治療・予防・支援)  258  -265  2018/01
• Performance Evaluation of Noise Reduction Algorithm for PET Amyloid Imaging Using Clinical Images.

  Yamada Takahiro; Kimura Yuichi; Fujii kosuke; Watanabe Shogo; Nagaoka Takashi; Nemoto Mitsutaka; Hanaoka Kohei; Kaida Hayato; Ishii Kazunari  Transactions of Japanese Society for Medical and Biological Engineering  56-  (0)  S294  -S294  2018
• 18F-FDG PETによる軽度認知障害からアルツハイマー型認知症への進展予測

  岡田 佑介; 岩田 香織; 加藤 隆司; 木村 泰之; 木澤 剛; 中村 昭範; 服部 英幸; 乾 好貴; 外山 宏; 石井 一成; 石井 賢二; 千田 道雄; 松田 博史; 伊藤 健吾; 岩坪 威; J-ADNI研究グループ  Dementia Japan  31-  (4)  606  -606  2017/10
• 進行性核上性麻痺と診断された進行性非流暢性失語症の一例

  高月 容子; 嶋田 兼一; 石井 一成; 寺島 明  日本神経心理学会総会プログラム・予稿集  41回-  91  -91  2017/09
• Volumetric parameterを用いた食道癌切除患者の予後因子の検討

  甲斐田 勇人; 石井 一成; 細川 知紗; 柳生 行伸; 任 誠雲; 兵頭 朋子; 山田 穣; 細野 眞; 安田 卓司; 村上 卓道  核医学  54-  (Suppl.)  S193  -S193  2017/09
• 健忘型MCI患者におけるアパシーの脳内基盤

  山本 諭希; 数井 裕光; 高橋 竜一; 吉山 顕次; 鐘本 英輝; 鈴木 由希子; 佐藤 俊介; 東 眞吾; 末廣 聖; 下瀬川 恵久; 石井 一成; 田中 稔久; 池田 学  日本神経心理学会総会プログラム・予稿集  41回-  137  -137  2017/09
• 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価

  山田 誉大; 木村 裕一; 藤井 康介; 渡辺 翔吾; 永岡 隆; 花岡 宏平; 細川 知紗; 石井 一成; 村上 卓道  核医学  54-  (Suppl.)  S210  -S210  2017/09
• 全身FDG PET/CT撮像において収集時間と画像再構成方法が定量性および画質に与える影響

  柴田 侑亮; 花岡 宏平; 渡邊 翔太; 奥村 雅彦; 石井 一成  日本放射線技術学会雑誌  73-  (9)  895  -895  2017/09
• 呼吸同期FDG PET/CTによる放射線治療計画について

  花岡 宏平; 奥村 雅彦; 西村 泰昌; 門前 一; 渡邊 翔太; 柴田 侑亮; 細野 眞; 石井 一成; 村上 卓道  核医学  54-  (Suppl.)  S167  -S167  2017/09
• 動態に基づいたアミロイドイメージング雑音除去アルゴリズムの性能評価

  山田 誉大; 木村 裕一; 藤井 康介; 渡辺 翔吾; 永岡 隆; 花岡 宏平; 細川 知紗; 石井 一成; 村上 卓道  核医学  54-  (Suppl.)  S210  -S210  2017/09
• 呼吸同期FDG PET/CTによる放射線治療計画について

  花岡 宏平; 奥村 雅彦; 西村 泰昌; 門前 一; 渡邊 翔太; 柴田 侑亮; 細野 眞; 石井 一成; 村上 卓道  核医学  54-  (Suppl.)  S167  -S167  2017/09
• 認知症の画像診断Up to date 認知症のSPECT/PET診断 FDG-PETの保険適応に向けて

  石井 一成  日本医学放射線学会秋季臨床大会抄録集  53回-  S382  -S383  2017/08
• 軽度認知機能患者におけるFDG-PETによるAD移行予測能の検討

  岡田 佑介; 岩田 香織; 加藤 隆司; 木村 泰之; 木澤 剛; 中村 昭範; 服部 英幸; 乾 好貴; 外山 宏; 石井 一成; 石井 賢二; 千田 道雄; 伊藤 健吾; 岩坪 威; J-ADNI Group  老年精神医学雑誌  28-  (増刊II)  168  -168  2017/06
• CAD System for Nuclear Medicine Brain Imaging

  ISHII Kazunari  Medical Imaging Technology  35-  (3)  129  -133  2017/05
• Integrated FDG-PET/MRI for whole-body staging in patients with recurrent gynecological cancer

  Kazuhiro Kitajima; Munenobu Nogami; Satoru Takahashi; Yoshiko Ueno; Yasuhiko Ebina; Kazuhiro Kubo; Utaru Tanaka; Keitaro Sofue; Takeaki Ishihara; Yuichi Wakabayashi; Kazunari Ishii; Kazuro Sugimura  JOURNAL OF NUCLEAR MEDICINE  58-  2017/05
• Prognostic impact of F-18-FDG PET parameters and molecular markers expression in resected non-small cell lung cancer patients.

  Hayato Kaida; Koichi Azuma; Akihiko Kawahara; Eiji Sadashima; Satoshi Hattori; Jun Akiba; Axel Rominger; Shinzo Takamori; Kiminori Fujimoto; Makoto Hosono; Kazunari Ishii; Takamichi Murakami; Masatoshi Ishibashi  JOURNAL OF NUCLEAR MEDICINE  58-  2017/05
• ¹¹C‐Pittsburgh Compound‐Bを用いたアミロイドイメージングにおいて画像再構成方法が半定量値へ与える影響

  渡邊翔太; 花岡宏平; 石井一成; 石井一成  日本放射線技術学会総会学術大会予稿集  73回-  138  -138  2017/03
• 脳脊髄液 正常圧水頭症の画像所見

  石井 一成  Japanese Journal of Diagnostic Imaging  35-  (1)  43  -43  2017/02
• 捻転を呈した漿膜下子宮筋腫の2例

  浜川 岳文; 松木 充; 沼本 勲男; 小田 晃義; 福井 秀行; 兵頭 朋子; 任 誠雲; 柳生 行伸; 今岡 いずみ; 鶴崎 正勝; 石井 一成; 村上 卓道  Japanese Journal of Diagnostic Imaging  35-  (1)  96  -96  2017/02
• ANCA関連腎炎に合併した縦隔線維症の1例

  日高 正二朗; 小塚 健倫; 浜川 岳文; 福井 秀行; 渡口 真史; 山田 穣; 任 誠雲; 柏木 伸夫; 細川 知紗; 鶴崎 正勝; 今岡 いずみ; 松木 充; 石井 一成; 村上 卓道  Japanese Journal of Radiology  35-  (Suppl.)  48  -48  2017/02
• 膀胱子宮内膜症の経過を追った2例

  沼本 勲男; 今岡 いずみ; 若林 雄一; 藤谷 哲也; 山川 美穂; 兵頭 朋子; 甲斐田 勇人; 柳生 行伸; 熊野 正士; 鶴崎 正勝; 松木 充; 石井 一成; 村上 卓道  Japanese Journal of Radiology  35-  (Suppl.)  49  -49  2017/02
• 上顎洞術後変化としての眼窩下管拡大

  福井 秀行; 柏木 伸夫; 任 誠雲; 甲斐田 勇人; 柳生 行伸; 小塚 健倫; 細川 知紗; 熊野 正士; 鶴崎 正勝; 松木 充; 今岡 いずみ; 石井 一成; 細野 眞; 村上 卓道  Japanese Journal of Radiology  35-  (Suppl.)  54  -54  2017/02
• FDG-PET/CTで集積を認めた異所性甲状腺癌の一例

  甲斐田 勇人; 石井 一成; 細川 知紗; 仁 誠雲; 細野 眞; 村上 卓道; 花岡 宏平; 乾 浩己  核医学  54-  (1)  668  -669  2017/02
• FDG-PET/CTで集積を認めた異所性甲状腺癌の一例

  甲斐田 勇人; 石井 一成; 細川 知紗; 仁 誠雲; 細野 眞; 村上 卓道; 花岡 宏平; 乾 浩己  核医学  54-  (1)  668  -669  2017/02
• 脳血流SPECT定性画像上のConvexity“APPArent”Hyperperfusion(CAPPAH)signがiNPHの診断に有用である

  大道卓摩; 近藤正樹; 徳田隆彦; 徳田隆彦; 小泉英貴; 松島成典; 栗山長門; 石井一成; 森悦朗; 山田惠; 水野敏樹  日本正常圧水頭症学会プログラム・抄録集  18th-  2017
• Development of automated delineation algorithm of reference regions for amyloid imaging. - Considering time information and the number of clusters -

  Yamada Takahiro; Kimura Yuichi; Nagaoka Takashi; Hanaoka Kohei; Hosokawa Chisa; Ishii Kazunari  Transactions of Japanese Society for Medical and Biological Engineering  55-  (4)  281  -281  2017
• 脳血流SPECT 123I-IMP

  石井 一成  核医学  53-  (Suppl.)  S225  -S225  2016/10
• 薬剤動態に基づいたアミロイドイメージングに対する雑音低減アルゴリズム

  木村 裕一; 藤井 康介; 山田 誉大; 細川 知紗; 坂田 宗之; 石井 一成; 村上 卓道  核医学  53-  (Suppl.)  S277  -S277  2016/10
• 非小細胞肺癌のFDG集積とGlut-1、pStat-1、pStat-3での予後因子の検討

  甲斐田 勇人; 東 公一; 河原 明彦; 服部 聡; 倉田 精二; 高森 信三; 藤本 公則; 鹿毛 政義; 石井 一成; 村上 卓道; 石橋 正敏  核医学  53-  (Suppl.)  S283  -S283  2016/10
• 認知症患者における線条体アミロイド沈着の検討

  細川 知紗; 石井 一成; Sauerbeck Julia; Sheiwein Franziska; 甲斐田 勇人; 兵頭 朋子; 山田 穣; 細野 眞; 花岡 宏平; 村上 卓道  核医学  53-  (Suppl.)  S276  -S276  2016/10
• 逐次近似応用再構成法が超急性期脳梗塞CT画像におけるZスコアマッピングに与える影響

  渡邊 翔太; 坂口 健太; 細野 眞; 石井 一成; 村上 卓道; 市川 勝弘  日本放射線技術学会雑誌  72-  (9)  813  -813  2016/09
• 左右差のある錐体外路症状と観念運動失行を示したレビー小体型認知症の一例 Corticobasal syndrome(CBS)の鑑別診断について

  嶋田 兼一; 石井 一成; 小田 陽彦; 長谷川 玲子; 牧野 史織; 土井 亜里紗; 熊尾 良子; 寺島 明  老年精神医学雑誌  27-  (増刊II)  189  -189  2016/06
• 放射性医薬品投与量の見直しと撮像技術 成人投与量の診断参考レベル

  石井 一成  核医学技術  36-  (2)  142  -143  2016/04
• 上顎洞術後変化としての眼窩下管拡大

  福井 秀行; 柏木 伸夫; 任 誠雲; 甲斐田 勇人; 柳生 行伸; 小塚 健倫; 細川 知紗; 熊野 正士; 鶴崎 正勝; 松木 充; 今岡 いずみ; 細野 眞; 石井 一成; 村上 卓道  Japanese Journal of Diagnostic Imaging  34-  (1)  116  -116  2016/02
• IgG4関連疾患によると思われる冠動脈病変の1例

  千葉 輝明; 松木 充; 今岡 いずみ; 熊野 正士; 小塚 健倫; 柏木 伸夫; 柳生 行伸; 足利 竜一朗; 鶴崎 正勝; 石井 一成; 村上 卓道; 平野 豊; 樋野 尚一  Japanese Journal of Radiology  34-  (Suppl.)  55  -55  2016/02
• 当院における胃粘膜下腫瘍に対する18F-FDG PET検査

  沼本 勲男; 松木 充; 福井 秀行; 若林 雄一; 渡口 真史; 千葉 輝明; 山田 穣; 柏木 伸夫; 細川 知紗; 小塚 健倫; 細野 眞; 石井 一成; 村上 卓道  Japanese Journal of Radiology  34-  (Suppl.)  56  -56  2016/02
• 脳神経系におけるPET画像診断

  石井 一成  日本放射線技術学会総会学術大会予稿集  72回-  109  -109  2016/02
• 当院における大腸内視鏡不完全症例に対するCT colonographyの活用

  松木充; 朝戸信行; 山川美帆; 藤谷哲也; 任誠雲; 兵頭朋子; 柳生行伸; 鶴崎正勝; 熊野正士; 今岡いずみ; 足利竜一朗; 石井一成; 村上卓道  Japanese Journal of Radiology  34-  (Suppl.)  57  -57  2016/02
• 11C-PiB PET陽性認知症の線条体集積の検討

  細川 知紗; 石井 一成; Sauerbeck Julia; Scheiwein Franziska; 甲斐田 勇人; 山田 穣; 兵頭 朋子; 細野 眞; 花岡 宏平; 村上 卓道  核医学  53-  (1)  561  -561  2016/02
• 薬剤動態に基づいたアミロイドイメージングに対する雑音低減アルゴリズム

  木村裕一; 藤井康介; 山田誉大; 細川知紗; 坂田宗之; 石井一成; 村上卓道  核医学(Web)  53-  (Supplement)  2016
• Validation of automated delineation algorithm of reference regions in PET amyloid imaging based on kinetics of administered amyloid probe

  Yamada Takahiro; Kimura Yuichi; Nagaoka Takashi; Okada Shima; Hosokawa Chisa; Ishii Kazunari  Transactions of Japanese Society for Medical and Biological Engineering  54-  (26)  S45  -S45  2016
• 認知症患者における線条体アミロイド沈着の検討

  細川知紗; 石井一成; SAUERBECK Julia; SHEIWEIN Franziska; 甲斐田勇人; 兵頭朋子; 山田穣; 細野眞; 花岡宏平; 村上卓道  核医学(Web)  53-  (Supplement)  1230(J‐STAGE)  2016
• ¹¹C‐PiB PET陽性認知症の線条体集積の検討

  細川知紗; 石井一成; SAUERBECK Julia; SCHEIWEIN Franziska; 甲斐田勇人; 山田穣; 兵頭朋子; 細野眞; 花岡宏平; 村上卓道  核医学(Web)  53-  (1)  561(J‐STAGE)  2016
• 単体ソフト薬事関連情報

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (31)  5  -5  2015/12
• 【Nuclear Medicine Today 2015 実臨床におけるPET/CT、SPECT/CTの意義と今後の展開】画像処理・ソフトウエアの最新動向 臨床現場における単体ソフトウエア時代への対応と課題

  石井 一成  INNERVISION  30-  (12)  56  -57  2015/11
• PET検診で発見されたFDG集積を伴う解離性大動脈瘤の一例

  甲斐田 勇人; 石井 一成; 村上 卓道; 田原 宣広; 本多 亮博; 福本 義弘; 石橋 正敏  核医学  52-  (4)  403  -403  2015/11
• The correlation between 18F-FDG uptake and Glut-1, Stat-1 and Stat-3 in non-small cell lung cancer patients.

  H. Kaida; K. Azuma; A. Kawahara; S. Hattori; S. Takamori; E. Sadashima; K. Fujimoto; M. Kage; S. Kurata; Y. Hirose; K. Ishii; T. Murakami; M. Ishibashi  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  42-  S298  -S298  2015/10
• Introducing the Glucose Metabolism to Amyloid Deposition Ratio Image

  K. Ishii; R. Takahashi; Y. Wakabyashi; C. Hosokawa; H. Kaida; T. Murakami  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  42-  S546  -S546  2015/10
• Therapy planning and dose prescription in radioiodine-131 therapy for hyperthyroidism using radioiodine-123 SPECT/CT imaging

  K. Hanaoka; M. Hosono; M. Otsuka; Y. Asai; M. Okumura; K. Ishii; T. Murakami  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  42-  S845  -S846  2015/10
• PETによる神経・精神疾患の分子イメージング レビー小体型認知症

  細川 知紗; 石井 一成  PET Journal  (31)  10  -11  2015/09
• 超急性期脳梗塞症例に対する頭部単純CT画像を用いたコンピューター支援診断システムの開発

  渡邊 翔太; 坂口 健太; 細野 眞; 石井 一成; 村上 卓道  日本放射線技術学会雑誌  71-  (9)  896  -896  2015/09
• 放射性医薬品投与量の見直しと撮像技術 成人投与量の診断参考レベル

  石井 一成  核医学  52-  (3)  095  -095  2015/09
• 膵癌のFDG集積とmTOR関連マーカーとの相関性に関する分子病理学的検討

  甲斐田 勇人; 東 公一; 河原 明彦; 安永 昌史; 服部 聡; 倉田 精二; 廣瀬 靖光; 鹿毛 政義; 石井 一成; 村上 卓道; 石橋 正敏  核医学  52-  (3)  248  -248  2015/09
• PiB陰性例の18F-FDG PETによる脳代謝分布の検討

  細川 知紗; 石井 一成; 若林 雄一; 兵頭 朋子; 花田 一志; 甲斐田 勇人; 細野 眞; 木村 裕一; 村上 卓道  核医学  52-  (3)  262  -262  2015/09
• アミロイドイメージングにおける組織放射能時間曲線に対するパターン認識による参照領域設定アルゴリズム

  木村 裕一; 山田 誉大; 細川 知紗; 石井 一成; 村上 卓道  核医学  52-  (3)  293  -293  2015/09
• 放射性医薬品投与量の見直しと撮像技術 成人投与量の診断参考レベル

  石井 一成  核医学技術  35-  (予稿集)  293  -293  2015/09
• The correlation of dual phase F-18-FDG PET/CT to immunohistochemical prognostic factors in breast cancer patients

  Hayato Kaida; Uhi Toh; Akihiko Kawahara; Seiji Kurata; Yasumitsu Hirose; Masayoshi Kage; Kazunari Ishii; Takamichi Murakami; Masatoshi Ishibashi  JOURNAL OF NUCLEAR MEDICINE  56-  (3)  2015/05
• Increased Pittsburgh Compound B accumulation in the regional white matters of Alzheimer brain

  Yuichi Wakabayashi; Kazunari Ishii; Chisa Hosokawa; Tomoko Hyodo; Takenori Kozuka; Takamichi Murakami; Kazuro Sugimura  JOURNAL OF NUCLEAR MEDICINE  56-  (3)  2015/05
• もの忘れ診断外来の自己記入問診票得点と認知機能の相関の検討

  花田 一志; 西郷 和真; 上田 昌美; 石井 一成; 白川 治; 福田 寛二  老年精神医学雑誌  26-  (増刊II)  206  -206  2015/05
• 認知症の画像診断

  石井 一成  大阪府内科医会会誌  24-  (1)  76  -76  2015/04
• 後縦隔に発生したectopic neural tissueの1例

  朝戸信行; 松木充; 福井秀行; 藤谷哲也; 任誠雲; 千葉輝明; 高橋洋人; 兵頭朋子; 山田稔; 柳生行伸; 鶴崎正勝; 岡田真広; 柏木伸夫; 細川知紗; 小塚健倫; 今岡いずみ; 足利竜一朗; 石井一成; 村上卓道  Jpn J Radiol  33-  (Suppl.)  77  -77  2015/02
• Prediction of Outcomes in Mild Cognitive Impairment by Using 18F-FDG-PET: A Multicenter Study

  Kengo Ito; SEAD-J Study Group; Hidenao Fukuyama; Michio Senda; Kazunari Ishii; Kiyoshi Maeda; Yasuji Yamamoto; Yasuomi Ouchi; Kenji Ishii; Ayumu Okumura; Ken Fujiwara; Takashi Kato; Yutaka Arahata; Yukihiko Washimi; Yoshio Mitsuyama; Kenichi Meguro; Mitsuru Ikeda  Journal of Alzheimer's Disease  45-  (2)  543  -552  2015  [Refereed]
  
• 嗜銀顆粒性認知症(Argyrophilic Grain Disease)と考えられた1例

  若林 雄一; 石井 一成; 河内 崇; 細川 知紗; 山川 美帆; 兵頭 朋子; 任 誠雲; 鶴崎 正勝; 足利 竜一郎; 松木 充; 細野 眞; 北村 登; 村上 卓道  核医学  51-  (4)  438  -439  2014/11
• Pet approaches for diagnosis of dementia

  K. Ishii  American Journal of Neuroradiology  35-  (11)  2030  -2038  2014/11
• Predictive value of heterogeneity of intratumoral In-111-Zevalin and FDG distributions for tumor response in Zevalin therapy

  M. Hosono; K. Hanaoka; K. Ishii; K. Sakaguchi; M. Yamada; Y. Komeya; N. Tsuchiya; S. Im; Y. Tatsumi; I. Matsumura  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  41-  S174  -S174  2014/10
• Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition

  K. Ishii; C. Hosokawa; T. Hyodo; Y. Wakabayashi; M. Yamada; T. Kozuka; M. Hosono; T. Murakami  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  41-  S619  -S619  2014/10
• 血中oxDJ-1の異常高値を示し、幻覚を認めたPDの4例

  西郷 和真; 斎藤 芳郎; 小川 郁子; 細井 幸恵; 三井 良之; 花田 一志; 上田 昌美; 石井 一成; 野口 範子; 楠 進  Dementia Japan  28-  (4)  504  -504  2014/10
• 軽症アルツハイマー病の18F-FDG PETと11C-PiB PET検査の経時的画像変化の検討

  細川 知紗; 石井 一成; 兵頭 朋子; 坂口 健太; 宇佐美 公男; 若林 雄一; 鶴崎 正勝; 松木 充; 細野 眞; 村上 卓道  核医学  51-  (3)  284  -284  2014/09
• 加齢の画像診断 最新情報 正常な加齢における脳血流量、代謝、およびアミロイドの蓄積(Imaging of Aging: up to date Cerebral blood flow, metabolism and amyloid deposition in normal aging)

  石井 一成  日本医学放射線学会秋季臨床大会抄録集  50回-  S593  -S593  2014/09
• 血中酸化型DJ‐1異常高値の臨床的意義

  西郷和真; 斎藤芳郎; 小川郁子; 細井幸恵; 三井良之; 花田一志; 上田昌美; 石井一成; 野口範子; 楠進  日本酸化ストレス学会学術集会プログラム・抄録集  67th-  52  2014/08
• Comparison between SUV and BP images acquired using 11C-PIB PET: Questionable PIB accumulation in SUV images

  Chisa Hosokawa; Kazunari Ishii; Yuichi Kimura; Kenta Sakaguchi; Makoto Hosono; Takamichi Murakami  JOURNAL OF NUCLEAR MEDICINE  55-  2014/05
• 多発結節影を呈した肺アミロイドーシスの1例

  日高 正二朗; 小塚 健倫; 柳生 行伸; 柏木 伸夫; 今岡 いずみ; 松木 充; 足利 竜一朗; 細野 眞; 石井 一成; 村上 卓道  Japanese Journal of Radiology  32-  (Suppl.)  39  -39  2014/02
• 蠕動運動の月経周期による変化を観察した双角子宮の1例

  荒木 哲朗; 今岡 いずみ; 日高 正二朗; 岡田 真広; 柳生 行伸; 松木 充; 足利 竜一朗; 石井 一成; 村上 卓道  Japanese Journal of Radiology  32-  (Suppl.)  40  -40  2014/02
• 腫瘤形成した慢性唾液腺炎のFDG-PET/CT所見

  細川 知紗; 柏木 伸夫; 松久保 祐子; 山田 穣; 任 誠雲; 兵頭 朋子; 高橋 洋人; 柳生 行伸; 岡田 真広; 小塚 健倫; 今岡 いずみ; 鶴崎 正勝; 松木 充; 足利 竜一郎; 細野 眞; 石井 一成; 村上 卓道; 筑後 雅章  Japanese Journal of Radiology  32-  (Suppl.)  45  -45  2014/02
• 認知症性疾患の多様性 正常圧水頭症

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (29)  16  -16  2013/12
• 11C-PIB-PETの視覚判定と定量評価 疑い判定の検討

  細川 知紗; 石井 一成; 木村 裕一; 兵頭 朋子; 坂口 健太; 宇佐美 公男; 細野 眞; 村上 卓道  核医学  50-  (4)  327  -327  2013/11
• Detection and Differential Diagnosis of Hepatic Metastasis on Gd-EOB-DTPA-Enhanced MR Imaging

  TSURUSAKI M; HYODO T; IM S; OKADA M; MATSUKI M; ASHIKAGA R; ISHII K; MURAKAMI T  NICHIDOKU-IHO  58-  (2)  203  -211  2013/11
• Computer assisted diagnosis system for dementia with 3D-SSP : ZSAM software

  石井 一成  臨床放射線  58-  (10)  1311  -1318  2013/10
• Therapy planning and dose prescription in radioiodine therapy for hyperthyroidism using SPECT/CT

  M. Hosono; K. Hanaoka; K. Ishii; S. Im; K. Sakaguchi; Y. Yagyu; Y. Matsukubo; Y. Ohno; H. Ikegami  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  40-  S231  -S232  2013/10
• PiB陽性MCIにおけるAPOE4のPiB取り込み、局所脳萎縮への効果

  高橋 竜一; 石井 一成; 松田 博史; 千田 道雄; 石井 賢二; 加藤 隆司; 伊藤 健吾; 杉下 守弘; 朝田 隆; 桑野 良三  Dementia Japan  27-  (4)  504  -504  2013/10
• ここが知りたい認知症の画像診断 脳血流SPECT/FDG-PET 基本的な読影のポイント

  石井 一成  日本医学放射線学会秋季臨床大会抄録集  49回-  S479  -S479  2013/09
• 脳FDG画像の読み方

  石井 一成  核医学  50-  (3)  S136  -S136  2013/09
• 11C-PIB PETのSUVR画像とBP画像の対比

  細川 知紗; 石井 一成; 木村 裕一; 兵頭 朋子; 細野 眞; 坂口 健太; 宇佐美 公男; 村上 卓道  核医学  50-  (3)  S182  -S182  2013/09
• 【脳神経系の画像診断ガイドライン】認知症ガイドライン 特発性正常圧水頭症

  石井 一成  画像診断  33-  (10)  1183  -1192  2013/08
• 【高次脳機能障害の核医学イメージング】正常圧水頭症

  石井 一成  PET Journal  (22)  35  -36  2013/06
• 大腿四頭筋血腫の経過で隣接骨の皮質過形成をきたした1例

  森田 敬裕; 柏木 伸夫; 兵頭 朋子; 柳生 行伸; 小塚 健倫; 熊野 正士; 今岡 いずみ; 石井 一成; 足利 竜一朗; 村上 卓道  Japanese Journal of Radiology  31-  (Suppl.I)  47  -47  2013/02
• 外傷性神経腫の1例

  藤谷 哲也; 柏木 伸夫; 今岡 いずみ; 熊野 正士; 石井 一成; 足利 竜一朗; 村上 卓道; 前西 修; 楠原 廣久; 磯貝 典孝  Japanese Journal of Radiology  31-  (Suppl.I)  53  -53  2013/02
• Dual-energy CTによる肝脂肪定量 ファントム実験によるsingle-energy CTおよびMRSとの比較

  兵頭 朋子; 岡田 真広; 工藤 正幸; 鶴崎 正勝; 足利 竜一朗; 石井 一成; 村上 卓道  日本医学放射線学会学術集会抄録集  72回-  S251  -S251  2013/02
• 3D Arterial spin labelingによるアルツハイマー病の脳灌流画像 SPECTとの比較(Brain perfusion imaging of Alzheimer's disease with 3D arterial spin labeling: Comparison with brain perfusion SPECT)

  高橋 洋人; 石井 一成; 柏木 伸夫; 宮越 敬三; 花岡 宏平; 村上 卓道  日本医学放射線学会学術集会抄録集  72回-  S282  -S282  2013/02
• 言語課題における「難易度」と脳賦活領域:fMRIによる検討

  岡田理恵子; 中野直樹; 宮内正晴; 石井一成; 村上卓道; 大槻俊輔; 加藤天美  日本ヒト脳機能マッピング学会プログラム・抄録集  15th-  84  2013
• 「3D-SSP解析による診断補助解析法」 Z-SAMによる検討

  石井 一成; 外山 宏  ブレイン・ファンクション・イメージング・カンファレンス記録集  (28)  8  -8  2012/12
• ¹¹¹In‐ゼバリンSPECT/CTで腫瘍活性残存を検出できた非ホジキンリンパ腫の一例

  米矢吉宏; 細野眞; 山田穣; 松木充; 花岡宏平; 坂口健太; 任誠雲; 柳生行伸; 石井一成; 辰巳陽一; 松村到; 土屋典生  核医学  49-  (4)  439  -439  2012/11
• 【年齢別特徴をふまえた脳神経画像診断-小児から成人まで-】感染症

  松木 充; 藤谷 哲也; 松久保 祐子; 高橋 洋人; 柏木 伸夫; 足利 竜一郎; 石井 一成; 村上 卓道  画像診断  32-  (13)  1252  -1267  2012/10
• Combination of FDG-PET and hippocampal volumetry for prediction of conversion to Alzheimer disease in subjects with mild cognitive impairments: Study on diagnosis of early Alzheimer disease-Japan (SEAD-J)

  K. Ishii; K. Ishii; T. Kato; M. Senda; K. Ito  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  39-  S434  -S435  2012/10
• Three dimensional planning of radioiodine therapy for hyperthyroidism by iodine-123 SPECT/CT

  K. Hanaoka; M. Hosono; T. Kurokawa; K. Sakaguchi; S. Yoshida; R. Inoue; K. Ishii; T. Murakami  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  39-  S309  -S309  2012/10
• Prediction of tumor response by Indium-111-Zevalin SPECT/CT and FDG-PET/CT in radioimmunotherapy for B-cell non-Hodgkin lymphoma

  M. Hosono; K. Hanaoka; K. Ishii; K. Sakaguchi; S. Im; N. Tsuchiya; Y. Komeya; Y. Yagyu; Y. Tatsumi; I. Matsumura  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  39-  S372  -S372  2012/10
• J-ADNI被験者の登録時区分によるFDG-PETの比較

  藤原 謙; 加藤 隆司; 石井 賢二; 石井 一成; 千田 道雄; 伊藤 健吾  Dementia Japan  26-  (4)  483  -483  2012/10
• 認知症の多施設共同研究をサポートする「ネット画像カンファレンスシステム」の開発

  中村 昭範; 加藤 隆司; 井狩 彌彦; 千田 道雄; 石井 一成; 石井 賢二; 西尾 知之; 宮 ゆかり; 伊藤 健吾; J-ADNI study group  Dementia Japan  26-  (4)  484  -484  2012/10
• Dual energy CTを用いた肝脂肪の定量評価 ファントム実験と初期臨床経験

  兵頭 朋子; 岡田 真広; 矢田 典久; 前西 修; 香川 祐毅; 任 誠雲; 柏木 伸夫; 柳生 行伸; 今岡 いずみ; 松木 充; 足利 竜一朗; 石井 一成; 工藤 正俊; 村上 卓道  近畿大学医学雑誌  37-  (3-4)  18A  -18A  2012/09
• 【よくわかる脳MRI(第3版)】変性疾患とその類縁疾患【認知症を来す疾患】Lewy小体型認知症、認知症を伴うパーキンソン病

  石井 一成  画像診断  別冊-  (よくわかる脳MRI第3版)  592  -593  2012/09
• 【よくわかる脳MRI(第3版)】変性疾患とその類縁疾患【認知症を来す疾患】特発性正常圧水頭症

  石井 一成  画像診断  別冊-  (よくわかる脳MRI第3版)  608  -609  2012/09
• 特発性正常圧水頭症の画像診断

  石井 一成  日本医学放射線学会秋季臨床大会抄録集  48回-  S458  -S458  2012/08
• Diagnostic imaging for idiopathic normal pressure hydrocephalus

  石井 一成  老年精神医学雑誌  23-  (7)  815  -820  2012/07
• 大脳皮質基底核変性症との鑑別が必要であった非典型的Prion病の一例

  嶋田 兼一; 小田 陽彦; 長谷川 雅史; 寺島 明; 石井 一成  老年精神医学雑誌  23-  (増刊II)  208  -208  2012/06
• 脳血管障害・認知症 (特集 糖尿病の画像診断 : CT/MR,核医学をどのように利用するか)

  高橋 竜一; 石井 一成  糖尿病  4-  (6)  27  -33  2012/06
• 【脳室と髄液腔の最新情報】特発性正常圧水頭症(iNPH) iNPHの画像診断

  石井 一成  Clinical Neuroscience  30-  (4)  420  -424  2012/04
• Diagnostic imaging in guidelines for management of idiopathic normal pressure hydrocephalus

  石井 一成; 塚部 明大; 森 悦朗; 新井 一; 石川 正恒  臨床放射線  57-  (3)  343  -348  2012/03
• Guidelines for Nuclear Medicine in Diabetes Mellitus and it's Complications

  西村 恒彦; 石井 一成; 奥山 智緒; 塩見 進; 玉木 長良; 中嶋 憲一; 中田 智明; 長谷 弘記; 畑澤 順; 藤林 靖久; 山崎 純一; 川村 悦史; 清野 泰; 小谷 晃平; 常喜 信彦; 高橋 竜一; 橋本 暁佳; 松尾 信郎; 松島 成典; 山科 昌平; 吉永 恵一郎; 渡部 直史; 柏木 厚典; 河盛 隆造; 島本 和明; 中村 直登; 山崎 義光  核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine  49-  (1)  16  -20  2012/02
• 慢性GVHDに伴う舌papillomatosisから発生した舌癌の1例

  加藤 里枝子; 勝部 敬; 下野 太郎; 石井 一成; 足利 竜一朗; 村上 卓道  Japanese Journal of Radiology  30-  (Suppl.I)  41  -41  2012/02
• Gd-EOB-DTPA造影MRIでの肝機能評価の試み T1 Mapping法を用いて

  勝部 敬; 岡田 真広; 熊野 正士; 藤谷 哲也; 森田 敬裕; 今岡 いずみ; 石井 一成; 村上 卓道  Japanese Journal of Radiology  30-  (Suppl.I)  43  -43  2012/02
• 高速多相撮像を用いた多血性肝細胞癌の最適撮像時間の検討

  香川 祐毅; 岡田 真広; 柳生 行伸; 小塚 健倫; 熊野 正士; 今岡 いずみ; 石井 一成; 足利 竜一朗; 村上 卓道  Japanese Journal of Radiology  30-  (Suppl.I)  47  -47  2012/02
• 知っておきたい認知症の画像診断 脳血流検査の要点

  石井 一成  日本医学放射線学会学術集会抄録集  71回-  S92  -S92  2012/02
• Dual energy CTを用いた肝脂肪の定量評価 ファントム実験と初期臨床経験

  兵頭 朋子; 岡田 真広; 矢田 典久; 工藤 正幸; 香川 祐毅; 熊野 正士; 石井 一成; 工藤 正俊; 村上 卓道  日本医学放射線学会学術集会抄録集  71回-  S272  -S272  2012/02
• ASIRを用いた低電圧肝Dynamic-CTによる被曝低減と造影剤量低減に関する報告

  日高 正二朗; 高橋 洋人; 岡田 真広; 兵頭 朋子; 香川 祐毅; 今岡 いずみ; 石井 一成; 足利 竜一朗; 工藤 正俊; 村上 卓道  日本医学放射線学会学術集会抄録集  71回-  S273  -S273  2012/02
• 認知症における脳血流SPECT読影ポイント

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (27)  15  -15  2011/12
• ガドキセト酸ナトリウム造影MRI肝細胞相で低信号を呈する乏血性結節の多血化予測

  兵頭 朋子; 岡田 真広; 香川 祐毅; 熊野 正士; 任 誠雲; 柏木 伸夫; 柳生 行伸; 今岡 いずみ; 足利 竜一朗; 石井 一成; 工藤 正俊; 村上 卓道  近畿大学医学雑誌  36-  (3-4)  13A  -13A  2011/12
• アルツハイマー病に対するFDG-PET・PIB-PETの読影者間一致に関する検討

  山根 登茂彦; 西尾 知之; 井狩 彌彦; 真喜志 瑶子; 石井 一成; 石井 賢二; 加藤 隆司; 伊藤 健吾; 千田 道雄  核医学  48-  (4)  466  -466  2011/11
• Indium-111-Zevalin-SPECT/CT and FDG-PET/CT as quantitative evaluation in radioimmunotherapy for B-cell non-Hodgkin's lymphoma

  K. Hanaoka; M. Hosono; Y. Yamazoe; Y. Tatsumi; Y. Komeya; N. Tsuchiya; K. Ishii; K. Usami; T. Murakami; T. Uto  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  38-  S426  -S426  2011/10
• FDG-PET and automatic diagnosis systems for prediction of conversion to Alzheimer disease in subjects with mild cognitive impairments: Study on diagnosis of early Alzheimer disease-Japan (SEAD-J)

  K. Ishii; K. Ito; M. Senda; K. Ishii; T. Kato; H. Fukuyama; Y. Ouchi; K. Meguro; A. Okumura; Y. Mitsuyama; G. Sead-J  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  38-  S108  -S109  2011/10
• PiB陽性、陰性aMCIにおける局所糖代謝の検討

  高橋 竜一; 石井 一成; 石井 賢二; 加藤 隆司; 千田 道雄; 伊藤 健吾; 杉下 守弘; 岩坪 威  Dementia Japan  25-  (3)  328  -328  2011/10
• PiB陽性aMCIにおけるApoE ε 4のPiB集積や局所糖代謝への効果

  高橋 竜一; 石井 一成; 石井 賢二; 加藤 隆司; 千田 道雄; 伊藤 健吾; 杉下 守弘; 桑野 良三; 岩坪 威  Dementia Japan  25-  (3)  329  -329  2011/10
• ストロンチウム-89を2回投与した骨転移症例の検討

  米矢 吉宏; 細野 眞; 土屋 典生; 熊野 正士; 山田 譲; 任 誠雲; 柳生 行伸; 石井 一成; 足利 竜一朗; 西村 恭昌; 村上 卓道  核医学  48-  (3)  S272  -S272  2011/09
• 特発性正常圧水頭症の脳血流SPECT 多施設共同研究SINPHONI CBF studyの報告

  石井 一成; 橋本 正明; 林田 孝平; 橋川 一雄; 張 家正; 中川原 譲二; 中山 禎司; 森 敏; 榊原 隆次  核医学  48-  (3)  S286  -S286  2011/09
• レビー小体型認知症の灰白質ならびに白質萎縮部位の検討

  高橋 竜一; 石井 一成; 柿木 達也; 横山 和正  神戸大学医学部神緑会学術誌  27-  (27)  65  -67  2011/08
• 脳FDG-PETと3D-SSPによるデータベース不要アルツハイマー病自動診断ソフトの開発

  石井 一成  近畿大学医学雑誌  36-  (1)  21A  -21A  2011/03
• 高速多相性CT撮像を用いた多血性肝細胞癌の最適な撮像時間の検討

  香川 祐毅; 岡田 真広; 柳生 行伸; 熊野 正士; 石井 一成; 村上 卓道  近畿大学医学雑誌  36-  (1)  19  -24  2011/03
• 特発性正常圧水頭症診療ガイドライン改訂(案)における画像診断

  石井 一成; 塚部 明大; 森 悦朗; 新井 一; 石川 正恒; 日本正常圧水頭症INPH診療ガイドライン改訂委員会  日本医学放射線学会学術集会抄録集  70回-  S133  -S134  2011/02
• Gd-EOB-DTPA造影MRIにおけるHCCのT1値の経時的変化について T1 mappingを用いた定量的な検討

  森田 敬裕; 熊野 正士; 岡田 真広; 兵頭 朋子; 柏木 伸夫; 柳生 行伸; 今岡 いずみ; 石井 一成; 足利 竜一朗; 村上 卓道  日本医学放射線学会学術集会抄録集  70回-  S275  -S276  2011/02
• SSFSE像におけるHCCに対するEOB造影の経時的影響 1.5Tと3.0Tの比較

  荒木 哲朗; 岡田 真広; 熊野 正士; 柳生 行伸; 柏木 伸夫; 小塚 健倫; 今岡 いずみ; 石井 一成; 足利 竜一朗; 村上 卓道  日本医学放射線学会学術集会抄録集  70回-  S276  -S276  2011/02
• Gd-EOB-DTPA造影MRI肝細胞相で検出された慢性障害肝の乏血性結節 多血化の危険因子

  兵頭 朋子; 岡田 真広; 香川 祐毅; 熊野 正士; 堀 雅敏; 石井 一成; 今井 康陽; 望月 輝一; 工藤 正俊; 村上 卓道  日本医学放射線学会学術集会抄録集  70回-  S342  -S343  2011/02
• 収集時間の減少が123I-IMP脳血流SPECT/CT検査に与える影響について

  花岡 宏平; 坂口 健太; 大塚 正和; 澄田 貢; 石井 一成; 村上 卓道; 細野 眞  日本放射線技術学会総会学術大会予稿集  67回-  251  -251  2011/02
• 減弱を考慮した副腎皮質アドステロール摂取率の簡易的な算出方法

  大塚 正和; 花岡 宏平; 宇佐美 公男; 澄田 貢; 石井 一成; 村上 卓道; 細野 眞  日本放射線技術学会総会学術大会予稿集  67回-  320  -320  2011/02
• 【腹部領域をみる 最新の画像診断トピックス】Iterative reconstruction CT

  村上 卓道; 岡田 真広; 今岡 いずみ; 石井 一成; 工藤 正幸  映像情報Medical  43-  (1)  28  -31  2011/01
• 照射野外固定の卵巣病変およびその機能性変化

  香川 祐毅; 今岡 いずみ; 加藤 里枝子; 安藤 里奈; 桑原 雅知; 岡田 真広; 熊野 正士; 石井 一成; 足利 竜一朗; 村上 卓道  Japanese Journal of Radiology  29-  (Suppl.I)  57  -57  2011/01
• 左視床前部梗塞における認知障害と視床-皮質回路離断

  西尾 慶之; 橋本 衛; 石井 一成; 伊藤 大輔; 麦倉 俊司; 高橋 昭喜; 森 悦朗  臨床神経学  50-  (12)  1150  -1150  2010/12
• 【認知症の画像診断 Alzheimer病から稀な疾患まで】機能画像診断 核医学

  石井 一成  画像診断  30-  (14)  1466  -1476  2010/11
• 【知っておきたい認知症の臨床と画像】疾患各論 正常圧水頭症

  石井 一成; 柿木 崇秀  臨床放射線  55-  (11)  1507  -1514  2010/10
• FDG uptake in bone marrow after G-CSF administration in patients with non-Hodgkin lymphoma

  K. Hanaoka; M. Hosono; Y. Komeya; N. Tsuchiya; K. Usami; Y. Yamazoe; K. Ishii; Y. Tatsumi; T. Murakami  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  37-  S433  -S433  2010/10
• Computer-assisted system for diagnosis of Alzheimer's disease using database-independent estimation using FDG PET and 3D-SSP

  K. Ishii; T. Uemura; N. Miyamoto; T. Yoshikawa  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  37-  S397  -S397  2010/10
• 【肝胆膵の転移性腫瘍】肝胆膵の転移性腫瘍 画像診断

  熊野 正士; 岡田 真広; 柳生 行伸; 今岡 いずみ; 石井 一成; 足利 竜一朗; 細野 眞; 村上 卓道  肝胆膵画像  12-  (5)  585  -591  2010/09
• RI標識モノクローナル抗体療法におけるIn-Zevalin、FDGの腫瘍集積と奏効の関係について

  花岡 宏平; 細野 眞; 米矢 吉宏; 土屋 典生; 山添 譲; 宇佐美 公男; 澄田 貢; 石井 一成; 村上 卓道  核医学  47-  (3)  432  -432  2010/09
• 各種ガイドラインに基づく脳神経核医学検査の有効活用 エビデンスに基づく脳神経核医学検査ガイドライン(認知症)

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (26)  27  -30  2010/09
• MCIからADへの移行予測指標の探索 FDG-PETを中心とした検討

  山田 貴史; 伊藤 健吾; 加藤 隆司; 目黒 謙一; 石井 賢二; 尾内 康臣; 鷲見 幸彦; 新畑 豊; 福山 秀直; 石井 一成; 千田 道雄  Dementia Japan  24-  (3)  305  -305  2010/09
• 健常者における脳糖代謝画像の変動要因ならびに認知機能との関係

  加藤 隆司; 伊藤 健吾; 千田 道雄; 石井 賢二; 石井 一成; 藤原 謙; 井狩 彌彦; 西尾 知之; 真喜志 瑶子  核医学  47-  (3)  398  -398  2010/09
• FDG-PET画像解析(AD-tsum法)を中心としたMCIからADへの移行予測の検討

  山田 貴史; 伊藤 健吾; 加藤 隆司; 福山 秀直; 千田 道雄; 尾内 康臣; 石井 一成; 石井 賢二; 目黒 謙一  核医学  47-  (3)  412  -412  2010/09
• Possibilities of the Evaluation in Liver Function with Gd-EOBDTPA Enhanced MRI

  Okada M; Katsube T; Kagawa Y; Hyodo T; Kumano S; Imaoka I; Ishii K; Imai Y; Kudo M; Murakami T  NICHIDOKU-IHOU  55-  (2)  179  -186  2010/09
• 急性期心筋梗塞患者における3T心臓MRI-T2強調画像の落とし穴

  河野 淳; 藤井 正彦; 杉村 和朗; 神田 知紀; 宮本 直和; 吉川 俊紀; 石井 一成; 谷口 泰代; 梶谷 定志  Japanese Journal of Radiology  28-  (Suppl.I)  46  -46  2010/07
• MRIおよびCTを用いた画像的肝機能評価

  岡田 真広; 熊野 正士; 勝部 敬; 香川 祐毅; 栗生 明博; 今岡 いずみ; 石井 一成; 今井 康陽; 工藤 正俊; 村上 卓道  日本医学放射線学会学術集会抄録集  69回-  S134  -S134  2010/02
• SPECT/CTによる脳血流SPECTの減弱補正効果

  栗生 明博; 石井 一成; 米谷 吉宏; 柳生 行伸; 熊野 正士; 足利 竜一朗; 細野 眞; 村上 卓道  日本医学放射線学会学術集会抄録集  69回-  S183  -S184  2010/02
• 油性造影剤マイオジールの頭蓋内MRI所見についての検討

  下野 太郎; 足利 竜一朗; 柳生 行伸; 桑原 雅知; 勝部 敬; 栗生 明博; 石井 一成; 村上 卓道  日本医学放射線学会学術集会抄録集  69回-  S206  -S206  2010/02
• 3T MRI高分解能画像による正常子宮の蠕動評価

  安藤 理奈; 今岡 いずみ; 香川 祐毅; 加藤 里枝子; 柳生 行伸; 岡田 真広; 熊野 正士; 石井 一成; 足利 竜一朗; 村上 卓道  日本医学放射線学会学術集会抄録集  69回-  S274  -S275  2010/02
• Gd-EOB-DTPA造影MRIと肝機能評価 T1 Mapping法を用いて

  勝部 敬; 岡田 真広; 熊野 正士; 香川 祐毅; 栗生 明博; 奥秋 知幸; 今岡 いずみ; 石井 一成; 足利 竜一朗; 村上 卓道  日本医学放射線学会学術集会抄録集  69回-  S293  -S293  2010/02
• 三次元差分処理を用いた副甲状腺SPECT/CT画像について

  花岡 宏平; 坂口 健太; 宇佐美 公男; 森元 英夫; 澄田 貢; 石井 一成; 細野 眞  日本放射線技術学会総会学術大会予稿集  66回-  226  -227  2010/02
• 呼吸同期装置を用いない呼吸同期SPECT収集の検討

  坂口 健太; 花岡 宏平; 森元 英夫; 宇佐美 公男; 澄田 貢; 石井 一成; 細野 眞  日本放射線技術学会総会学術大会予稿集  66回-  280  -280  2010/02
• Disruption of Thalamocortical Interconnections in Neurobehavioral Disturbance after Left Anterior Thalamic Infarction

  Yoshiyuki Nishio; Mamoru Hashimoto; Kazunari Ishii; Daisuke Ito; Shunji Mugikura; Shoki Takahashi; Etsuro Mori  ANNALS OF NEUROLOGY  68-  (4)  S67  -S68  2010
• CAD System for Diagnosis of Dementia

  ISHII Kazunari  Medical Imaging Technology  28-  (1)  14  -18  2010/01
• 脳PETの現状と将来展望

  石井 一成  PET Journal  (8)  7  -9  2009/12
• エビデンスに基づく脳神経核医学検査ガイドライン : 2009年

  橋川 一雄; 岡沢 秀彦; 小笠原 邦昭; 奥 直彦; 下瀬川 恵久; 中川原 譲二; 林田 孝平; 石井 一成; 伊藤 健吾; 桑原 康雄; 松田 博史; 東海林 幹夫; 大槻 泰介  核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine  46-  (4)  1  -37  2009/11
• MCIを対象としたアルツハイマー型痴呆の早期診断に関する研究(J-COSMIC) 画像解析(2)

  石井 一成; 伊藤 健吾; 松田 博史; 桑原 康雄; 橋川 一雄; 百瀬 敏光; 内田 佳孝; 畑澤 順; 蓑島 聡; 米倉 義晴  核医学  46-  (3)  266  -266  2009/09
• 認知症の診断と治療の最新情報 追加発言 アルツハイマー病における脳核医学検査ガイドライン

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (25)  69  -70  2009/09
• アルツハイマー病早期診断に関する研究(SEAD-J)とUS-ADNIにおけるMCI患者の特徴とFDG-PET画像の比較

  川嶋 将司; 加藤 隆司; 伊藤 健吾; 千田 道雄; 石井 一成; 石井 賢二; 福山 秀直; 尾内 康臣; 目黒 謙一  核医学  46-  (3)  266  -266  2009/09
• ApoE遺伝子多型による初老期および老年期発症アルツハイマー病の灰白質萎縮部位の差の検討

  石井 一成  神緑会学術誌  25-  61  -63  2009/08
• 【老年精神医学の臨床最前線】認知症の診断-Update 認知症の早期・鑑別診断における機能画像の役割

  石井 一成  老年精神医学雑誌  20-  (増刊III)  42  -49  2009/08
• ApoE遺伝子多型による初老期および老年期発症アルツハイマー病の灰白質萎縮部位の差の検討 (助成研究報告)

  石井 一成  神戸大学医学部神緑会学術誌  25-  (25)  61  -63  2009/08
• 【MRIによる認知機能障害の早期診断】認知症診断におけるMRIとPETの比較・優劣

  石井 一成  Cognition and Dementia  8-  (2)  75  -81  2009/04
• マルチモダリティ時代における核医学の役割 認知障害

  石井 一成  核医学  46-  (1)  46  -47  2009/03
• 認知症の画像診断A to Z SPECT,PETを用いた認知症の診断

  石井 一成  日本医学放射線学会学術集会抄録集  68回-  S69  -S69  2009/02
• 核医学 脳核医学の基礎と臨床 臨床編

  石井 一成  日本医学放射線学会学術集会抄録集  68回-  S93  -S93  2009/02
• 腸骨動脈領域の末梢動脈疾患に対する血管内治療の有用性についての検討

  宮本 直和; 福田 哲也; 上村 尚文; 後藤 一; 吉川 俊紀; 石井 一成; 杉村 和朗  日本医学放射線学会学術集会抄録集  68回-  S216  -S216  2009/02
• 胸部大動脈疾患に対するMKステントグラフト内挿術の有用性に関する検討

  上村 尚文; 宮本 直和; 福田 哲也; 吉田 正人; 向原 伸彦; 吉川 俊紀; 後藤 一; 石井 一成  日本医学放射線学会学術集会抄録集  68回-  S350  -S350  2009/02
• 脳MRI・核医学画像統合 自動脳定量解析ソフトの開発・臨床応用

  石井 一成; 相馬 努  INNERVISION  24-  (2)  101  -105  2009/01
• 鎖骨下動脈狭窄/閉塞症に対する血管形成術

  溝部 敬; 中村 貢; 本岡 康彦; 田中 一寛; 宮本 直和; 石井 一成  JNET: Journal of Neuroendovascular Therapy  2-  (4)  268  -268  2008/11
• 【核医学の最前線】進化するソフトウェア 3D-SSPによる脳機能解析

  石井 一成  Rad Fan  6-  (12)  36  -39  2008/10
• Multicenter cerebral perfusion SPECT study in idiopathic normal pressure hydrocephalus

  K. Ishii; M. Hashimoto; K. Hayashida; K. Hashikawa; C. C. Chang; T. Nakayama; J. Nakagawara; S. Mori; R. Sakakibara  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  35-  S313  -S313  2008/10
• 脳神経核医学 認知症の画像診断 認知症の核医学診断

  石井 一成  日本医学放射線学会秋季臨床大会抄録集  44回-  S483  -S484  2008/09
• MCIを対象とするアルツハイマー病の早期診断に関する多施設共同研究(SEAD-J) 登録データの初期解析結果

  伊藤 健吾; 千田 道雄; 石井 一成; 石井 賢二; 加藤 隆司; 福山 秀直; 尾内 康臣; 目黒 謙一  核医学  45-  (3)  S180  -S180  2008/09
• MCIを対象とするアルツハイマー病の早期診断に関する多施設共同研究(SEAD-J)におけるPET画像の中央読影

  清水 敬二; 千田 道雄; 石井 一成; 石井 賢二; 加藤 隆司; 松本 圭一; 伊藤 健吾  核医学  45-  (3)  S195  -S195  2008/09
• MCIのconverterとnon-converterにおけるリバーミード行動記憶検査

  阪井 一雄; 大川 慎吾; 嶋田 兼一; 石井 一成; 大山 明美; 前田 潔  老年精神医学雑誌  19-  (増刊II)  123  -123  2008/06
• PTAを施行した腹腔動脈起始部圧迫症候群の1例

  原田 文; 宮本 直和; 神田 知紀; 吉川 俊紀; 石井 一成; 五味 隆  IVR: Interventional Radiology  23-  (2)  220  -220  2008/04
• 外傷性内胸動脈損傷の一例

  北村 アキ; 宮本 直和; 溝口 和博; 本多 祐; 尾崎 喜就; 中桐 啓太郎; 吉田 正人; 向原 伸彦; 石井 一成; 志田 力  日本血管外科学会雑誌  17-  (2)  424  -424  2008/03
• 特発性正常圧水頭症の排尿障害と右前頭葉血流低下:[123I]‐IMP SPECTによる検討

  榊原隆次; 内田佳孝; 石井一成; 白井厚治; 内山智之; 山西友典  日本内科学会雑誌  97-  (Suppl.)  251  -251  2008/02
• 3.0T装置におけるNASA法を用いた下肢非造影MRAの閉塞性動脈硬化症に対する有用性についての検討

  神田 知紀; 宮本 直和; 石本 剛; 上村 尚文; 吉川 俊紀; 石井 一成; 杉村 和朗  日本医学放射線学会学術集会抄録集  67回-  S169  -S169  2008/02
• ApoE遺伝子多型による初老期および老年期発症アルツハイマー病の灰白質萎縮部位の差

  石井 一成; 高橋 竜一; 神田 知紀; 上村 尚文; 宮本 直和; 吉川 俊紀; 保田 稔; 森 悦朗  日本医学放射線学会学術集会抄録集  67回-  S245  -S245  2008/02
• レビー小体型認知症の診断における神経心理検査の有用性の検討

  嶋田 兼一; 石井 一成; 山根 有美子; 福田 義文; 大川 愼吾  臨床神経学  47-  (12)  1145  -1145  2007/12
• 腸骨動脈慢性完全閉塞病変PTA後の遠位塞栓による急性動脈閉塞に対して経皮的血栓除去術を行った2例

  宮本 直和; 福田 哲也; 上村 尚文; 神田 知紀; 吉川 俊紀; 石井 一成; 向原 伸彦  IVR: Interventional Radiology  22-  (4)  499  -499  2007/10
• 前頭側頭型認知症における局所脳糖代謝・灰白質密度の検討

  神田 知紀; 石井 一成; 宮本 直和; 上村 尚文  核医学  44-  (3)  302  -302  2007/10
• 特発性正常圧水頭症の排尿障害と右前頭葉血流低下:[123I]‐IMP SPECTによる検討

  榊原隆次; 内田佳孝; 石井一成; 数井裕光; 橋本正明; 石川正恒; 湯浅龍彦; 白井厚治; 服部孝道; 内山智之; 山西友典; PHONI Sin  日本排尿機能学会誌  18-  (1)  117  -118  2007/10
• 進行胃癌に合併した肺動脈腫瘍塞栓の1例

  河野 淳; 中林 美日; 杉村 和朗; 石井 一成; 宮本 直和; 福田 哲也  日本医学放射線学会秋季臨床大会抄録集  43回-  S463  -S463  2007/09
• 当院にて経験したPopliteal Artery Entrapment Syndrome

  河野 淳; 石井 一成; 祖父江 慶太郎; 宮本 直和; 福田 哲也  日独医報  52-  (1)  129  -129  2007/05
• 急性腎不全を来したI型大動脈解離による腎動脈狭窄に対してstentを留置した1例

  宮本 直和; 福田 哲也; 祖父江 慶太郎; 河野 淳; 吉川 俊紀; 石井 一成; 圓尾 文子; 向原 伸彦; 吉田 正人; 志田 力  IVR: Interventional Radiology  22-  (2)  267  -267  2007/04
• MRIによる早期アルツハイマー型認知症診断システムの開発

  石井 一成  兵庫県医師会医学雑誌  49-  (2)  126  -127  2007/03
• Imaging diagnosis of idiopathic normal pressure hydrocephalus

  石井 一成  臨床放射線  52-  (3)  449  -457  2007/03
• 脳統計学的画像診断法の発展とピットフォール

  石井 一成; 祖父江 慶太郎; 宮本 直和; 吉川 俊紀  日本医学放射線学会学術集会抄録集  66回-  S105  -S105  2007/02
• 腎動脈狭窄に対する経皮的腎血管形成術 腎機能悪化予防についての検討

  祖父江 慶太郎; 宮本 直和; 福田 哲也; 吉川 俊紀; 石井 一成  日本医学放射線学会学術集会抄録集  66回-  S257  -S257  2007/02
• 認知症をどう診るか? 認知症診療の実際 誌上ディベート アルツハイマー病の早期診断に有効なのはアミロイドイメージングか、脳代謝・血流画像か 脳代謝・血流画像であるとの立場から

  石井 一成  Cognition and Dementia  6-  (1)  74,4  -78,4  2007/01
• Urinary dysfunction and right frontal hypoperfusion in idiopathic normal pressure hydrocephalus; An [123I]-IMP SPECT study

  R. Sakakibara; Y. Uchida; K. Ishii; H. Kazui; M. Hashimoto; M. Ishikawa; T. Uchiyama; T. Yamamoto; H. Takahashi; K. Shirai; T. Hattori  NEUROUROLOGY AND URODYNAMICS  26-  (5)  612  -613  2007
• レビー小体型認知症の診断におけるMIBG心筋シンチの有用性の検討

  嶋田 兼一; 石井 一成; 中村 佐智子; 寺島 明; 阪井 一雄; 尾崎 健一郎; 清水 光太郎; 大川 愼吾  臨床神経学  46-  (12)  1004  -1004  2006/12
• 意味性痴呆における記憶障害の神経基盤

  西尾慶之; 石井一成; 数井裕光; 細貝良行; 博野信次; 森悦朗  日本神経学会総会プログラム・抄録集  46-  (12)  1004  -1004  2006/12
• 123I-IMP脳血流SPECTを施行したReye症候群の1例

  河野 淳; 石井 一成; 祖父江 慶太郎; 宮本 直和; 金田 純子; 喜多 也寸志; 杉村 和朗  核医学  43-  (4)  367  -367  2006/11
• 正常圧水頭症

  石井 一成  核医学 : 日本核医学会機関誌 : the Japanese journal of nuclear medicine  43-  (3)  S100  2006/10
• 予防と治療につながる脳核医学 正常圧水頭症

  石井 一成  核医学  43-  (3)  144  -144  2006/10
• 軽症レビー小体型認知症とアルツハイマー病のFDG-PET全自動コンピューター補助診断

  河野 淳; 石井 一成; 祖父江 慶太郎; 宮本 直和; 坂本 攝; 杉村 和朗  核医学  43-  (3)  242  -243  2006/10
• Comparison of morphologic and metabolic reduction in mild dementia with Lewy bodies and Alzheimer disease

  K. Ishii; T. Soma; A. K. Kono; K. Sofue; N. Miyamoto; A. Sakurai; K. Murase  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  33-  S295  -S295  2006/09
• 特発性脊椎硬膜外血腫の2例

  河野 淳; 藤井 正彦; 杉村 和朗; 祖父江 慶太郎; 宮本 直和; 石井 一成; 木村 英仁; 本岡 康彦; 川口 哲郎  日本医学放射線学会秋季臨床大会抄録集  42回-  S518  -S518  2006/09
• TASCB・C型腸骨動脈病変に対する血管内治療とbypass術の比較

  宮本 直和; 福田 哲也; 祖父江 慶太郎; 河野 淳; 吉川 俊紀; 石井 一成; 杉村 和朗; 吉田 正人; 向原 伸彦; 志田 力  脈管学  46-  (Suppl.)  S204  -S204  2006/09
• 一過性の運動障害を呈しprobable DLBと診断した2症例

  嶋田 兼一; 寺島 明; 石井 一成; 吉原 育男; 大川 慎吾  老年精神医学雑誌  17-  (増刊I)  203  -203  2006/06
• 弓部大動脈置換術後,腕頭動脈吻合部仮性瘤に対してstent graft留置が有用であった1例

  宮本 直和; 福田 哲也; 河野 淳; 石井 一成; 井上 武; 吉田 正人; 大保 英文; 向原 伸彦; 志田 力  IVR: Interventional Radiology  21-  (2)  210  -210  2006/04
• SPECTからみたMCIとアルツハイマー病

  石井 一成  認知神経科学  8-  (1)  35  -38  2006/03
• MRIによる特発性正常圧水頭症の診断

  石井 一成; 河野 淳; 宮本 直和; 福田 哲也  日本医学放射線学会学術集会抄録集  65回-  S95  -S95  2006/02
• 非閉塞性腸間膜虚血の検討

  河野 淳; 福田 哲也; 宮本 直和; 石井 一成  日本医学放射線学会学術集会抄録集  65回-  S159  -S159  2006/02
• TASC B・C型腸骨動脈病変に対する血管内治療とbypass術におけるQOLの比較

  宮本 直和; 福田 哲也; 河野 淳; 石井 一成; 杉村 和朗  日本医学放射線学会学術集会抄録集  65回-  S331  -S332  2006/02
• FDG-PETによるSCA3とOPCAの比較

  田畑 昌子; 東 靖人; 宮石 雅浩; 水谷 好志; 佐々木 将博; 石井 一成  臨床神経学  45-  (12)  1167  -1167  2005/12
• 痴呆を伴うパーキンソン病のFDG-PETによる検討

  東 靖人; 田畑 昌子; 宮石 雅浩; 佐々木 将博; 水谷 好志; 石井 一成  臨床神経学  45-  (12)  1184  -1184  2005/12
• Frontal-subcortical circuit disruption subsequent to upper pontine infarct

  Y Nishio; K Ishii; H Kazui; Y Hosokai; N Hirono; E Mori  JOURNAL OF THE NEUROLOGICAL SCIENCES  238-  S518  -S519  2005/11
• 線条体黒質変性症のFDG-PETについて

  田畑 昌子; 宮石 雅浩; 東 靖人; 石井 一成  臨床神経学  45-  (10)  779  -779  2005/10
• 本邦にて進行中のEBM trial SINPHONI

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (21)  55  -58  2005/10
• Assessment of Parkinson disease with dementia by FDG-PET

  Y. Higashi; M. Miyaishi; M. Tabata; M. Sasaki; K. Ishii  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  32-  S186  -S186  2005/09
• 心臓MRIが診断に有用であった心膜欠損症の1例

  河野 淳; 石井 一成; 佐々木 弘喜; 宮本 直和; 福田 哲也  日独医報  50-  (3)  589  -589  2005/09
• MRI Zスコア画像を用いた早期アルツハイマー病診断法の開発

  石井 一成  神緑会学術誌  21-  143  -144  2005/08
• MRI Zスコア画像を用いた早期アルツハイマー病診断法の開発 (助成研究報告)

  石井 一成  神戸大学医学部神緑会学術誌  21-  (21)  143  -144  2005/08
• SPECTからみたMCIとアルツハイマー病

  石井 一成  認知神経科学  7-  (2)  135  -135  2005/07
• 弓部大動脈置換術後,腕頭動脈吻合部仮性瘤に対してstent graft留置が有用であった1例

  宮本 直和; 福田 哲也; 河野 淳; 石井 一成; 井上 武; 吉田 正人; 大保 英文; 向原 伸彦; 志田 力  IVR: Interventional Radiology  20-  (3)  326  -326  2005/07
• Evaluation of Activation and Decommissioning of the Medical Compact Cyclotron

  ISHIMOTO Takeshi; KUBOTA Haruyuki; MORI Tetsuya; TERAKAWA Kimihito; TANI Kuniharu; ISHII Kazunari  Radioisotopes  54-  (6)  185  -192  2005/06
• 【脳画像の新たな展開】基礎研究と開発 脳機能画像統計解析 SPMと3D-SPP

  石井 一成  最新医学  60-  (5)  980  -987  2005/05
• 腸骨動脈慢性完全性閉塞に対する血管内治療の初期成績 Zp的困難例の解析を含めて

  福田 哲也; 杉本 幸司; 河野 淳; 佐々木 弘喜; 宮本 直和; 石井 一成; 杉村 和朗  日本医学放射線学会学術集会抄録集  64回-  S142  -S143  2005/02
• TASC B・C型腸骨動脈病変に対する血管内治療に関する中期成績の検討

  宮本 直和; 福田 哲也; 河野 淳; 佐々木 弘喜; 石井 一成  日本医学放射線学会学術集会抄録集  64回-  S142  -S142  2005/02
• MRI-VBMによるZ score画像を使用した軽症アルツハイマー病の診断

  石井 一成; 佐々木 弘喜; 河野 淳; 宮本 直和; 福田 哲也  日本医学放射線学会学術集会抄録集  64回-  S153  -S153  2005/02
• 16列MDCTを用いた閉塞性動脈硬化症の術前評価 PTA術中血管内超音波所見と比較して

  佐々木 弘喜; 福田 哲也; 河野 淳; 宮本 直和; 石井 一成  日本医学放射線学会学術集会抄録集  64回-  S329  -S329  2005/02
• 下肢急性動脈閉塞に対する経皮的血栓除去術の初期成績

  宮本 直和; 福田 哲也; 河野 淳; 佐々木 弘喜; 石井 一成; 吉田 正人; 大保 英文; 向原 伸彦; 志田 力  IVR: Interventional Radiology  20-  (2)  214  -215  2005/02
• 特発性正常圧水頭症患者の海馬萎縮の検討

  橋本 衛; 数井 裕光; 石井 一成; 松本 圭司; 中野 葉子; 大川 慎吾; 森 悦朗  臨床神経学  44-  (12)  1154  -1154  2004/12
• 脳のMRI診断338症例 成人発症の脱髄変性疾患

  大場 洋; 寺田 一志; 下野 太郎; 酒井 美緒; 森 墾; 藤井 裕太; 小川 敏英; 松尾 周也; 石亀 慶一; 和田 昭彦; 豊田 圭子; 石井 一成; 安藤 久美子; 高田 晃一; 石藏 礼一  画像診断  別冊-  (新版よくわかる脳MRI)  352  -435  2004/10
• 【痴呆性疾患における脳機能画像統計解析の臨床的有用性と信頼性】統計学的画像解析のOVERVIEW

  石井 一成  臨床放射線  49-  (10)  1195  -1201  2004/10
• 腸骨動脈慢性完全閉塞性病変に対する血管内治療の初期成績

  福田 哲也; 石井 一成; 南 裕也; 吉田 正人; 大保 英文; 向原 伸彦; 志田 力  脈管学  44-  (9)  535  -535  2004/09
• 3D-SSPを用いたiNPH患者のIMP SPECT脳血流定性画像の検討

  佐々木 弘喜; 石井 一成; 河野 淳; 宮本 直和; 福田 哲也  核医学  41-  (3)  348  -348  2004/09
• Stent-assisted Coil Embolizationにて救命しえた解離性椎骨動脈瘤破裂の1例

  河野 淳; 福田 哲也; 佐々木 弘喜; 多喜 雅人; 小島 芳夫; 石井 一成; 柴田 裕次; 岩倉 昌岐; 小松 英樹; 川口 哲郎; 杉本 幸司; 杉村 和朗; 廣田 省三  IVR: Interventional Radiology  19-  (3)  307  -307  2004/07
• 総大腿動脈を含む外腸骨動脈狭窄・閉塞に対しての血管形成,ステント留置術

  福田 哲也; 杉本 幸司; 河野 淳; 佐々木 弘喜; 小島 芳夫; 石井 一成; 廣田 省三; 杉村 和朗  日本医学放射線学会雑誌  64-  (2)  S114  -S114  2004/02
• 閉塞性動脈硬化症患者における頸動脈超音波の有用性 術前スクリーニングとしての意義について

  河野 淳; 福田 哲也; 佐々木 弘喜; 小島 芳夫; 石井 一成  日本医学放射線学会雑誌  64-  (2)  S230  -S230  2004/02
• 初老期及び老年期発症軽症アルツハイマー病の灰白質萎縮部位の差 VBMによる検討

  石井 一成; 佐々木 弘喜; 河野 淳; 福田 哲也; 小島 芳夫  日本医学放射線学会雑誌  64-  (2)  S322  -S322  2004/02
• 失語を伴う進行性核上性麻痺の一例

  高月 容子; 中野 葉子; 石井 一成; 北田 香織; 田渕 正康; 森 悦朗  神経心理学  19-  (4)  236  -236  2003/12
• 【痴呆症学 高齢社会と脳科学の進歩】臨床編 痴呆の診断 画像検査(ニューロイメージング) 機能画像検査 PETによる痴呆分類

  石井 一成; 森 悦朗  日本臨床  61-  (増刊9 痴呆症学(1))  473  -478  2003/12
• 失語を伴う進行性核上性麻痺の一例

  高月 容子; 中野 葉子; 石井 一成; 北田 香織; 田渕 正康; 森 悦朗  神経心理学  19-  (4)  236  -236  2003/12
• 軽症アルツハイマー病における局所ブドウ糖代謝の1年間の継時的変化

  博野 信次; 橋本 衛; 石井 一成; 数井 裕光; 森 悦朗  臨床神経学  43-  (12)  923  -923  2003/12
• クリニカルPETの現況について 脳 腫瘍,てんかん,痴呆

  石井 一成  日本医学放射線学会雑誌  63-  (7)  S350  -S351  2003/09
• 失語を伴う進行性核上性麻痺の一例

  高月 容子; 中野 葉子; 石井 一成; 北田 香織; 田渕 正康; 森 悦朗  日本神経心理学会総会プログラム・予稿集  27回-  136  -136  2003/09
• 早期アルツハイマー病の臨床診断 MCIのMRI及び核医学診断

  石井 一成  Dementia Japan  17-  (2)  152  -152  2003/08
• 痴呆性疾患における脳機能画像統計解析の臨床的有用性と信頼性 統計学的画像解析のOVERVIEW

  石井 一成  核医学  40-  (3)  277  -277  2003/08
• PET用院内サイクロトロン廃止時における放射線管理 兵庫県立姫路循環器病センターでの経験

  森 哲也; 石井 一成; 久保田 晴元; 石本 剛  核医学  40-  (3)  388  -388  2003/08
• 軽症アルツハイマー病におけるFDG-PET及びMRI-VBMによる機能・形態変化の検討

  佐々木 弘喜; 石井 一成; 河野 淳; 福田 哲也  核医学  40-  (3)  315  -315  2003/08
• 統計画像の臨床応用 Overview

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (18)  33  -36  2003/07
• クリニカルPETの将来展望 痴呆疾患への応用

  石井 一成  核医学  40-  (2)  223  -223  2003/05
• Dementia and PET

  石井 一成  新医療  30-  (3)  104  -107  2003/03
• Clinical Dementia Rating(CDR)0.5患者の局所脳ブドウ糖代謝

  石井 一成; 小島 芳夫; 福田 哲也; 多喜 雅人  日本医学放射線学会雑誌  63-  (2)  S165  -S165  2003/02
• A Japanese Nationwide Survey on the FDG-PET Scans for Dementia: Analysis on the Predicted Costs and Benefits of FDG-PET for Early Diagnosis of Alzheimer

  SENDA Michio; KUWABARA Yasuo; ITO Kengo; HAYASHIDA Kohei; OKAZAWA Hidehiko; UNO Kimiichi; NAKASHIMA Toshihiko; OKU Naohiko; TORIZUKA Kanji; OUCHI Yasuomi; ISHII Kazunari; ISHII Kenji; IKEDA Shunya; NASU Seiji; KAWABE Joji; ISHIZU Koichi; KATO Noriyuki  RADIOISOTOPES  52-  (11)  585  -598  2003
• 急性期に治療し得たIII b型大動脈解離に合併した腎虚血の1例

  多喜 雅人; 福田 哲也; 奥野 晃章; 小島 芳夫; 石井 一成; 向原 伸彦; 廣田 省三; 杉本 幸司; 杉村 和朗  IVR: Interventional Radiology  18-  (1)  67  -67  2003/01
• 脳血流測定による診断と治療のモニタリング 痴呆診断において脳血流量測定の必要性はあるか?

  石井 一成  ブレイン・ファンクション・イメージング・カンファレンス記録集  (17)  37  -42  2002/11
• Coil塞栓術を施行した骨髄線維症に合併した脾動脈瘤の1例

  奥野 晃章; 福田 哲也; 多喜 雅人; 小島 芳夫; 石井 一成; 杉本 幸司; 藤井 正彦; 杉村 和朗; 廣田 省三  日本医学放射線学会雑誌  62-  (12)  720  -720  2002/10
• 生化学画像の臨床的意義 血流イメージングから分子イメージングへ 痴呆におけるFDGイメージング

  石井 一成  核医学  39-  (3)  258  -258  2002/09
• 統計学的手法を用いた局所脳ブドウ糖代謝率画像測定法の開発

  石井 一成; 坂本 攝; 松井 美詠子  神緑会学術誌  18-  (18)  101  -102  2002/08
• 【痴呆の画像診断 形態と機能からのアプローチ】PET

  石井 一成  臨床放射線  47-  (7)  885  -893  2002/07
• Noninvasive quantification of cerebral glucose metabolism using multiple regression analysis method without arterial blood sampling.

  S Sakamoto; K Ishii; K Hosaka; T Mori; M Sasaki; M Senda  JOURNAL OF NUCLEAR MEDICINE  43-  (5)  237P  -237P  2002/05
• Comparison of F-18-FDG-PET and I-123-IMP-SPECT findings in dementia with Lewy bodies.

  K Hosaka; K Ishii; M Matsui; M Sasaki; T Mori; E Mori; K Sugimura  JOURNAL OF NUCLEAR MEDICINE  43-  (5)  255P  -255P  2002/05
• 【ここまでわかる脳機能画像 現状と展望】PET/SPECT アルツハイマー病の核医学診断

  石井 一成  画像診断  22-  (5)  500  -508  2002/04
• 【画像診断 先端画像と治療への応用】21世紀の画像診断と治療 PET クリニカルPETの時代へ

  石井 一成  最新医学  57-  (3)  462  -467  2002/03
• 顕著なclosing-in現象を示したアルツハイマー型痴呆の一例

  小久保 香江; 今村 徹; 石井 一成; 森 悦朗  神経心理学  17-  (4)  281  -281  2001/12
• 【放射線医学の新展開 到達点と将来展望】核医学 中枢神経領域の核医学

  石井 一成  現代医療  33-  (10)  2549  -2554  2001/10
• Quantitative analysis of spatio-temporal distribution of spatial attention in a patient with Alzheimer disease

  MATSUMOTO Eriko; IMAMURA Toru; ISHII Kazunari; MORI Etsuro; MIYAUCHI Satoru  神経心理学 : Japanese journal of neuropsychology  17-  (3)  201  -212  2001/09
• 顕著なClosing-in現象を示したアルツハイマー型痴呆の一例

  小久保 香江; 今村 徹; 石井 一成; 森 悦朗  日本神経心理学会総会プログラム・予稿集  25回-  126  -126  2001/08
• Difference of metabolic impairment between early and late onset types of Alzheimer's disease.

  S Sakamoto; K Ishii; M Matsui; K Hosaka; T Mori; M Sasaki; E Mori  JOURNAL OF NUCLEAR MEDICINE  42-  (5)  13P  -14P  2001/05
• Anatomic validation of spatial normalization methods for FDG-PET: SPM and NEUROSTAT.

  K Hosaka; S Sakamoto; K Ishii; M Senda; N Sadato; H Fukuda; T Kato; K Sugimura  JOURNAL OF NUCLEAR MEDICINE  42-  (5)  216P  -216P  2001/05
• 【内科医のためのアルツハイマー病 診断と治療の最前線】アルツハイマー病の診断 画像で診断するアルツハイマー病

  石井 一成  Modern Physician  21-  (4)  415  -419  2001/04
• Semantic dementiaの脳局所糖代謝の検討

  坂本 攝; 松井 美詠子; 佐々木 將博; 森 哲也; 石井 一成; 森 悦朗  核医学  38-  (2)  168  -169  2001/03
• 左一側性視床polar artery領域梗塞の症候学的・神経放射線学的検討

  橋本 衛; 博野 信次; 谷向 知; 今村 徹; 埴原 秋児; 数井 裕光; 石井 一成; 坂本 攝; 高月 容子; 森 悦朗  臨床神経学  40-  (12)  1325  -1325  2000/12
• アルツハイマー型痴呆の局所脳糖代謝の発症時期による相違

  坂本 攝; 松井 美詠子; 佐々木 將博; 森 哲也; 保坂 加代; 杉村 和朗; 石井 一成  核医学  37-  (5)  543  -543  2000/09
• Difference in detectability of hypomatabolic regions in Alzheimer's disease. Comparison between early and ordinary scans of FDG-PET.

  S Sakamoto; K Ishii; M Matsui; M Sasaki; T Mori; K Hosaka  JOURNAL OF NUCLEAR MEDICINE  41-  (5)  218P  -218P  2000/05
• 【アルツハイマー病をめぐる最近の諸問題】アルツハイマー病の機能画像 Positron Emission Tomography(PET),Single Photon Emission Computed Tomography(SPECT),fMRIについて

  坂本 攝; 石井 一成; 松井 美詠子  カレントテラピー  18-  (4)  610  -613  2000/03
• アルツハイマー型痴呆の経過中の脳体積変化 頭部MRIの三次元立体表示と体積測定による検討

  松井 美詠子; 坂本 攝; 石井 一成; 北垣 一; 畑 豊; 杉村 和朗  日本医学放射線学会雑誌  60-  (2)  S260  -S260  2000/02
• 反復する幻視を呈しPETで後頭葉に局所脳糖代謝低下を認めた1例

  今村 徹; 埴原 秋児; 森 悦朗; 石井 一成  臨床神経学  39-  (10)  1083  -1083  1999/10
• 軽症Alzheimer型痴呆における1年経過後の局所脳ブドウ糖代謝低下部位の検討

  松井 美詠子; 石井 一成; 佐々木 將博; 森 哲也; 坂井 洋登; 北垣 一  核医学  36-  (6)  603  -603  1999/08
• 痴呆性疾患の核医学診断(PET)

  石井 一成  日本医事新報  (3925)  33  -36  1999/07
• Timetable-like daily living and stereotyped roaming after a right hemispheric infarction

  IMAMURA Toru; FUJIMORI Misato; ISHII Kazunari; MORI Etsuro; IKEDA Manabu  神経心理学  15-  (2)  124  -131  1999/06
• Regional cerebral blood flow difference between dementia with Lewy bodies and Alzheimer's disease.

  K Ishii; S Yamaji; H Kitagaki; T Imamura; N Hirono; E Mori  JOURNAL OF NUCLEAR MEDICINE  40-  (5)  268P  -268P  1999/05
• 意味記憶の神経基盤 PETを用いたアルツハイマー病患者の検討

  博野 信次; 森 悦朗; 石井 一成  認知神経科学  1-  (1)  81  -83  1999/04
• 皮質基底核変性症の局所脳糖代謝

  石井 一成; 坂本 攝; 山路 滋; 林 直子; 北垣 一  日本医学放射線学会雑誌  59-  (2)  S153  -S153  1999/02
• 頭部MRIの三次元立体表示と体積測定による皮質基底核変性症とアルツハイマー病の診断

  北垣 一; 石井 一成; 畑 豊  日本医学放射線学会雑誌  59-  (2)  S228  -S228  1999/02
• Disinhibited Behavior after a Right Temporal Lobe Infarction

  MANO Keiko; IMAMURA Toru; FUJIMORI Misato; ISHII Kazunari; MORI Etsuro  神経心理学  14-  (4)  233  -241  1998/12
• 【胸部孤立性陰影エンサイクロペディア】血管原性結節 気管支動脈瘤

  石井 一成  日本胸部臨床  57-  (増刊)  S42  -S43  1998/11
• 脳ブドウ糖代謝を測定したMarchiafava-Bignami病の1例

  石井 一成; 佐々木 將博; 山路 滋; 北垣 一; 坂井 洋登; 紀田 利; 池尻 義隆; 森 悦朗  核医学  35-  (9)  981  -981  1998/11
• 123I-IMP SPECt脳血流画像を用いたレヴィー小体を伴う痴呆とアルツハイマー病の鑑別診断

  森 悦朗; 石井 一成; 北垣 一; 今村 徹; 博野 信次  Dementia Japan  12-  (2)  140  -140  1998/09
• Lewy小体をともなう痴呆(Dementia with Lewy bodies:DLB)における幻視と局所脳糖代謝との関係

  今村 徹; 石井 一成; 博野 信次; 橋本 衛; 谷向 知; 数井 裕光; 埴原 秋児; 森 悦朗  Dementia Japan  12-  (2)  144  -144  1998/09
• Lewy bodyを伴う痴呆(DLB)の局所脳血流

  石井 一成; 山路 滋; 佐々木 將博; 紀田 利; 北垣 一  核医学  35-  (7)  542  -542  1998/08
• Frontotemporal dementia and Alzheimer disease: evaluation of cortical atrophy with automated hemispheric surface display generated with MR images.

  H Kitagaki; E Mori; S Yamaji; K Ishii; N Hirono; S Kobashi; Y Hata  Radiology  208-  (2)  431  -9  1998/08  [Refereed]
  
• Standardized uptake value to assess cerebral glucose metabolism in Alzheimer's disease.

  S Yamaji; K Ishii; M Sasaki; H Kitagaki; S Sakamoto; E Mori  JOURNAL OF NUCLEAR MEDICINE  39-  (5)  163P  -163P  1998/05
• Frontotemporal dementiaの局所脳糖代謝

  石井 一成  日本医学放射線学会雑誌  58-  (2)  S42  -S42  1998/02
• Cerebellar metabolic reduction in Alzheimer's disease and data normalization - Reply

  K Ishii; S Yamaji; E Mori  JOURNAL OF NUCLEAR MEDICINE  39-  (2)  375  -376  1998/02
• Delusions of oral parasitosis.

  K Maeda; Y Yamamoto; M Yasuda; K Ishii  Progress in neuro-psychopharmacology & biological psychiatry  22-  (1)  243  -8  1998/01  [Refereed]
  
• Age at onset and regional cerebral glucose metabolism in Alzheimer's disease

  Fumihiko Yasuno; Toru Imamura; Nobutsugu Hirono; Kazunari Ishii; Masahiro Sasaki; Yoshitaka Ikejiri; Mamoru Hashimoto; Tatsuo Shimomura; Hikari Yamashita; Etsuro Mori  Dementia and Geriatric Cognitive Disorders  9-  (2)  63  -67  1998
• 頭部MRIの立体表示と体積測定による変性性痴呆性疾患の診断

  北垣 一; 山路 滋; 石井 一成; 森 悦朗; 小橋 昌司; 畑 豊  日本磁気共鳴医学会雑誌  17-  (Suppl.)  103  -103  1997/09
• 軽症アルツハイマー型痴呆の海馬糖代謝

  石井 一成  核医学  34-  (8)  660  -660  1997/08
• アルツハイマー病において海馬血流量は低下しない!?

  石井 一成  日本医学放射線学会雑誌  57-  (2)  S72  -S72  1997/02
• Exacerbation of Palilalia with Trihexyphenidyl in Progressive Supranuclear Palsy

  SATO Mutsumi; IMAMURA Toru; MORI Etsuro; ISHII Kazunari; TSUTSUMI Akira  神経心理学 : Japanese journal of neuropsychology  12-  (3)  197  -203  1996/09
• Alzheimer型痴呆の局所脳酸素摂取率

  石井 一成  断層映像研究会雑誌  21-  (2)  178  -178  1995/03
• Alzheimer型痴呆脳の循環酸素代謝 PETガススタディによる検討

  坂本 攝; 石井 一成; 北垣 一; 佐々木 將博; 紀田 利; 山路 滋; 河野 通雄  核医学  31-  (7)  713  -713  1994/07
• 痴呆患者のInteruncal Distance MRIによる検討

  石井 一成  日本医学放射線学会雑誌  54-  (3)  337  -337  1994/03
• NONINVASIVE THYMOMA IN A 15-YEAR-OLD GIRL - CT FINDINGS

  K ISHII; M KONO; K MAEDA  AMERICAN JOURNAL OF ROENTGENOLOGY  160-  (4)  894  -895  1993/04
• 成人にて発見された巨大重複腸管嚢腫の1例

  石井 一成; 前田 一憲; 鷲尾 哲郎  臨床放射線  37-  (6)  717  -720  1992/06
• MR appearance of a retained surgical sponge [8]

  K. Ishii; K. Maeda; M. Kono  American Journal of Roentgenology  158-  (2)  460  1992
• 胸部ガーゼ腫のMRI

  石井 一成  医療  45-  (増刊)  593  -593  1991/10
• 123I-IMPによる局所脳血流量の定量的評価

  平井 宏和; 山崎 克人; 山路 滋; 野村 曜子; 石井 一成; 北垣 一; 田中 豊; 白坂 今日子; 井上 善夫; 河野 通雄  核医学  28-  (8)  889  -889  1991/08
• 肺癌のGa-67SPECTの集積度の半定量化に関する検討

  野村 曜子; 山崎 克人; 山路 滋; 平井 宏和; 石井 一成; 北垣 一; 田中 豊; 白坂 今日子; 井上 善夫; 河野 通雄  核医学  28-  (8)  906  -906  1991/08
• 肺癌におけるTl-201を用いたSPECTによる集積度の半定量化への試み

  山路 滋; 山崎 克人; 野村 曜子; 平井 宏和; 石井 一成; 北垣 一; 田中 豊; 白坂 今日子; 井上 善夫; 河野 通雄  核医学  28-  (8)  908  -908  1991/08
• 気管支動脈瘤の1例

  石井 一成; 長谷川 義記; 前田 一憲  日本胸部臨床  50-  (8)  677  -680  1991/08
• A case of esophageal intramural pseudodiverticulosis.

  ISHII Kazunari; HASEGAWA Yoshiki; MAEDA Kazunori; NAKAHARA Yukiko; NAKAHARA Yasuharu; KONO Michio  Nippon Shokakibyo Gakkai Zasshi  88-  (7)  1454  -1458  1991/07
• 盲腸膜様閉鎖症の1例

  石井 一成; 前田 一憲; 西平 友彦  胃と腸  26-  (6)  693  -696  1991/06
• 小児縦隔腫瘍のCTおよびMRI

  石井 一成  医療  44-  (増刊)  290  -290  1990/10
• 褐色細胞腫のMRI

  石井 一成; 吉田 裕; 松井 律夫  臨床放射線  35-  (9)  1021  -1026  1990/09
• 盲腸膜様閉鎖の1例

  石井 一成  日本医学放射線学会雑誌  50-  (6)  710  -710  1990/06

Awards & Honors

• 2016/11 2016年久田賞(Annals of Nuclear Medicine 論文賞)銅賞
  
• 2008/04 金原出版株式会社 平成20年 臨放論文賞
  
• 2006/04 日本医学放射線学会 第65回 日本医学放射線学会最多アクセス賞
  
• 1999/10 日本核医学会 第37回 日本核医学会賞
  
• 1999/02 コニカ株式会社 第5回 コニカ画像科学奨励賞
   

  受賞者: 石井一成

Research Grants & Projects

• Application of gamma entrainment to patients with schizophrenia and its effect on hippocampal pathology

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2022/04 -2026/03 

  Author : 柳 雅也; 橋本 衛; 石井 一成; 難波 寿明
• 多施設連携プラットフォーム(MABB)を基盤にした各種認知症性疾患に対する日本発の包括的な診断・層別化バイオマーカーシステムの確立

  日本医療研究開発機構(AMED)：認知症研究開発事業

  Date (from‐to) : 2021/04 -2026/03
• 血液バイオマーカーと神経画像検査によるBPSDの生物学的基盤の解明、および認知症者の層別化に基づいたBPSDケア・介入手法の開発研究

  日本医療研究開発機構(AMED)：認知症研究開発事業

  Date (from‐to) : 2021/04 -2026/03
• 食道癌術前化学療法の治療効果予測―低酸素イメージングと癌シグナル伝達因子との相関

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2021/04 -2025/03 

  Author : 甲斐田 勇人; 石井 一成; 安田 卓司; 伊藤 彰彦; 細野 眞; 服部 聡; 河原 明彦

   

  本研究の目的は、術前化学療法を受ける進行食道癌患者対象に治療開始前FMISO PET/CTで治療効果予測が可能か病理学的評価を踏まえて検討することである。さらにFMISO集積で腫瘍内低酸素やPD-L1やCD8T細胞が発現する腫瘍免疫環境を予測可能か前向き研究で検討する。 科研費交付決定後に近畿大学医学部倫理委員会に研究計画書を提出し、一括申請を行った。倫理委員会で研究実施実施計画が承認された後に食道癌の病理組織標本に免疫染色行うための抗体やFMISOの薬剤合成にかかる消耗品の購入、FMISO PET/CTの検査が円滑に進められるように研究体制を整えた。倫理委員会承認後本研究を開始し、共同研究を行う上部消化管外科と密接に連携して、研究に参加可能な対象者を集め始めた。初年度は研究体制整備が主だった実績となった。 今年度は10症例程度を目標に予定していたが、医学部倫理委員会に申請する研究計画書の作成やその審査にかなり時間を要し、計画に遅れが生じた。次年度からは研究に該当する食道癌患者の収集を第一に努め、収集症例数をあげることである。また、食道癌の術前化学療法後、手術を行った患者の病理染色標本の染色および患者の経過観察に関して円滑に進めていけるように関係各所（近畿大学上部消化管外科、近畿大学病理学講座、久留米大学病院病理部病理診断科、大阪大学大学院医学系研究科情報統合医学講座医学統計学）との連携を再確認して、随時研究の打ち合わせの実施を行う。
• ディープラーニングを用いたマンモグラム時系列解析による対側乳癌予測システムの開発

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2021/04 -2024/03 

  Author : 山室 美佳; 李 鎔範; 浅井 義行; 石井 一成

   

  乳腺密度を軸とする対側乳癌発症リスク予測システム確立の基礎実験として、先行研究で収集済みの3000症例の生データマンモグラムについて人工知能技術を用い、乳腺密度算出のための乳腺領域を抽出するU-netモデルを作成した. 今後、過去に遡っての画像や、他院で撮影された画像を研究に利用できるようにするため、当院の標準画像処理条件で作成した乳腺領域抽出のためのU-netモデルが、異なる画像処理を行ったマンモグラムに適用できるかどうかを評価した. 4つの異なる処理を施した画像に作成したU-netを適応して抽出された領域の乳腺密度とGround Truthを比較し、Bland-Altman解析を行った. その結果、ダイナミックレンジ圧縮を強くするとU-netモデルへの影響が顕著となり、固定誤差や比例誤差を生じる要因となるため注意が必要ではあるが、日常診療で使用される範囲内での画像処理の違いはU-netモデルの適用精度に顕著な影響を及ぼすことはなく、少なくともGround Truthとの互換性が保たれていると判断できた. 次にRaw dataを用いず、臨床画像に付帯している情報のみで乳腺密度を推定するための予備実験を行なった. 簡易的に画素値のみで乳腺を含むと判断した領域の乳腺密度値2223例について、重回帰式を作成すると乳腺密度の全変動の90%程度を説明できることがわかった. これらの研究と同時に2000例程度の生データマンモグラムを追加収集した. そのうち1700例程度が対側乳癌症例であり、更にこの内７割が連続してデータ収集できている症例であった.
• 血液バイオマーカーによる認知症の統合的層別化システムの開発

  日本医療研究開発機構(AMED)：次世代治療・診断実現のための創薬基盤技術開発事業

  Date (from‐to) : 2019/04 -2024/03
• To elucidate the prognostic marker using amino acid PET imaging and signal transduction factors in brain tumor patients

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/04 -2021/03 

  Author : KAIDA HAYATO

   

  The aim of this study is to reveal the correlation and prognostic factors among 11C-methionine (MET) uptake and signal transduction factors and to investigate the pathological relationship between amino acid metabolism and tumor cell proliferation in glioma patients undergoing both PET/CT and operation. Our data showed that MET uptake in glioma had positive correlation with L-type amino acid transporter-1 (LAT-1) and that MET uptake in glioma have potential role in predicting both the degree of malignancy and epidermal growth factor receptor (EGFR). Our data also suggest that LAT-1 expression may be related with tumor hypoxia.
• 適時適切な医療・ケアを目指した、認知症の人等の全国的な情報登録・追跡を行う研究

  日本医療研究開発機構（AMED)：長寿・障害総合研究事業

  Date (from‐to) : 2016/04 -2020/03
• Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2011 -2013 

  Author : ISHII Kazunari; MURAKAMI Takamichi; OKADA Masahiro; KUMANO Seishi

   

  The purpose of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the dementia with Lewy bodies (DLB) brain. Methods: Ten consecutive subjects with DLB and 10 Alzheimer disease (AD) patients who underwent both PiB-PET and FDG-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG and PiB PET images.Results: All AD patients and five DLB patients showed amyloid deposits (PiB positive). The parietotemporal and occipital metabolism in the DLB group were significantly lower than those in the AD group. In DLB patients, there were no differences in regional glucose metabolism between PiB positive and negative patients. Conclusions: In the DLB brain, decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area.

Other link

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https://researchmap.jp/kazunarius