SHIRAI Atsushi

Researcher Information

Degree

• Ph.D. (Engineering)（Tohoku University）

URL

http://db.tohoku.ac.jp/whois/detail/4549a5511af54bb6c2fc5141c27c7bf5.html

J-Global ID

• 200901092805327707

Research Interests

• Ventricular Assist Device   鏡療法   Numerical Analysis   Capillary   Neutrophil   

Research Areas

• Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Fluid engineering / Biofluid Mechanics

Education

•        - 1998/03  Graduate School of Tohoku University  School of Engineering  Department of Mechanical Engineering
•        - 1993/03  Tohoku University  School of Engineering  機械工学第二学科

Association Memberships

• 計測自動制御学会   日本機械学会   

Published Papers

• Influence on Measurement Signal by Pressure and Viscosity Changes of Fluid and Installation Condition of FBG Sensor Using Blood Flow Simulation Model

  Shouhei Koyama; Toshiyuki Hayase; Suguru Miyauchi; Atsushi Shirai; Shun Chino; Yuki Haseda; Hiroaki Ishizawa

  IEEE Sensors Journal 19 (24) 11946 - 11954 1530-437X 2019/12 [Refereed]
   

  © 2001-2012 IEEE. We are working on the development of a sensor that can calculate various vital signs from the signals measured by installing a Fiber Bragg Grating (FBG) sensor at the pulsation point of a living body. In this paper, the influence of blood flow parameters and sensor installation conditions on the FBG sensor signal was verified using two blood flow simulation models. From the results of our study, the following observations were made. The fluid pressure increases, the wavelength shift of the FBG sensor beca me larger. By contrast, an increase in the viscosity of the fluid was seen to cause a decrease in the displacement length of the Bragg wavelength. Fluid pressure and viscosity were observed to opposite effects on the FBG sensor signal. The Bragg wavelength shift of the FBG sensor was observed to be larger when the installation direction of the FBG sensor was perpendicular to the blood flow direction than in the parallel direction. However, FBG sensor signals with higher signal-to-noise (S/N) ratio were measured at an angle of 75 degrees than at an angle of 90 degrees, which is perpendicular to the blood flow direction. From the above results, the installation condition of the FBG sensor on the measurement signal and the influence of each parameter of blood flow were established.
• Modeling of alveolar microcirculation for passage of neutrophils

  Atsushi Shirai

  Proc. 15th international Conference on Flow Dynamics (ICFD2018) 638 - 639 2018/11 [Invited]
  
• Elucidation of mechanism of Fiber Bragg Grating vital sensing by Ultrasonic-Measurement-Integrated simulation: Flow analysis in ultrasound flow phantom

  Suguru Miyauchi; Toshiyuki hayase; Kosuke Inoue; Toshiyuki Ogasawara; Tatsuya Tsuboi; Atsushi Shirai; Shun Chino; Shouhei Koyama; Hiroaki Ishizawa

  Proc. 15th International Conference on Flow Dynamics (ICFD2018) 602 - 603 2018/11
• Fundamental evaluation of a pulse wave measurement system mimicking pulse diagnosis using a wrist pulsatile blood flow model

  Tatsuya Tsuboi; Atsushi Shirai; Suguru Miyauchi; Toshiyuki Hayase

  Proc. 15th International Conference on Flow Dynamics (ICFD2018) 714 - 715 2018/11
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelial topography: Influence of pressing force on cell trajectories

  Atsushi Shirai; Jean-Paul Rieu

  ELyT Workshop 2018 Abstract Book USB-Memory  2018/03
• A methodology to generate a randomly oriented capillary network on alveolus

  Atsushi Shirai; Kentaro Yamada

  Proc. 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE2018) #102  2018/03
• Differentiation of neutrophil-like HL-60 cells strongly impacts their rolling on surfaces with various adhesive properties under a pressing force

  Atsushi Shirai; Yoshiro Sugiyama; Jean-Paul Rieu

  Technology and Health care 26 (1) 93 - 108 2018/03 [Refereed]
  
• Rolling experiment of HL-60 cells on patterned PDMS substrate coated by P-selectin

  Toshiki Arai; Atsushi Shirai; Jean-Paul Rieu

  Proc. 14th International Conference on Flow Dynamics (ICFD2017) 288 - 289 2017/11
• Fundamental measurement of pulsation on a wrist pulsatile blood flow model using a pulse wave measurement system mimicking pulse diagnosis

  Tatsuya Tsuboi; Atsushi Shirai

  Proc. 14th International Conference on Flow Dynamics (ICFD2017) 422 - 423 2017/11
• Universality of periodic oscillation induced in side branch of a T-junction in numerical simulation

  Ryuhei Yamaguchi; Gaku Tanaka; Tadashi Nakagawa; Atsushi Shirai; Hao Liu; Toshiyuki Hayase

  Journal of Flow Control, Measurement & Visualization 5 (4) 73 - 85 2017/10 [Refereed]
  
• Photoplethysmography and ultrasonic-measurement-integrated simulation to clarify the relation between two-dimensional unsteady blood flow field and forward and backward waves in a carotid artery

  Shusaku Sone; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  Medical & Biological Engineering & Computing SPRINGER HEIDELBERG 55 (5) 719 - 731 0140-0118 2017/05 [Refereed]
   

  Understanding the spatiotemporal change in hemodynamics is essential for the basic research of atherosclerosis. The objective of this study was to establish a methodology to clarify the relation between a two-dimensional (2D) unsteady blood flow field and forward and backward propagating waves in a carotid artery. This study utilized photoplethysmography (PPG) for blood pressure measurement and two-dimensional ultrasonic-measurement-integrated (2D-UMI) simulation for flow field analysis. The validity of the methodology was confirmed in an experiment for a carotid artery of a healthy volunteer. Synchronization between the pressure measurement and flow field analysis was achieved with an error of < 10 ms. A 2D unsteady blood flow field in the carotid artery was characterized in relation to forward and backward waves. 2D-UMI simulation reproduced the flow field in which the wall shear stress takes a maximum at the time of the backward wave superiority in the systolic phase, whereas 2D ordinary simulation failed to reproduce this feature because of poor reproducibility of velocity distribution. In conclusion, the proposed methodology using PPG and 2D-UMI simulation was shown to be a potential tool to clarify the relation between 2D unsteady blood flow field and the forward and backward waves in a carotid artery.
• Fundamental study on generation of a 3-D alveolar capillary network model based on the bubble mesh method

  Kentaro Yamada; Atsushi Shirai

  Proc. 15th International Conference on Flow Dynamics (ICFD2018) #E3-0003  2016/12
• Influence of pressing force on rolling characteristics of HL-60 cell line on a bumpy substrate mimicking the endothelium topography

  Atsushi Shirai; Jean-Paul Rieu; Ryota Sugimoto; Daisuke Yoshino

  Proc. The 16th International conference on biomedical engineering (ICBME2016) #E2-0006  2016/12
• Numerical analysis for elucidation of mechanical interaction between an erythrocyte moving in medium subject to inclined centrifugal force and endothelial cells on a plate

  Akira Yatsuyanagi; Toshiyuki Hayase; Suguru Miyauchi; Kenichi Funamoto; Kosuke Inoue; Atsushi Shirai; Luca Brandt

  Journal of Fluid Science and Technology 11 (4) JFST0029  2016/12 [Refereed]
  
• Correlative effect of normal force and P-selectin concentration on rolling behavior of neutrophils

  Ryota Sugimoto; Atsushi Shirai; Daisuke Yoshino; Jean-Paul Rieu

  Proc. 13th International Conference on Flow Dynamics (ICFD2016) 704 - 705 2016/10
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelial topography: PTV analysis of the cells motion on regular hexagonal pattern

  Atsushi Shirai; Jean-Paul Rieu; Ryota Sugimoto; Daisuke Yoshino

  Proc. 13th International Conference on Flow Dynamics (ICFD2016) 286 - 287 2016/10
• Development of 2-D pulmonary capillary network model based on the bubble mesh method: Effects of segmentation and treatment of border capillaries on capillary length

  Kentaro Yamada; Atsushi Shirai

  Proc. 13th International Conference on Flow Dynamics (ICFD2016) 278 - 279 2016/10
• Numerical reproduction of hemodynamics change by acupuncture on Taichong (LR-3) based on the lumped-parameter approximation model of the systemic arteries

  Atsushi Shirai; Takuya Suzuki; Takashi, Seki

  Integrative Medicine Research 4 (3) 161 - 170 2016/09 [Refereed]
  
• Numerical simulation of propulsion mechanism of small aquatic creatures by ciliated swimming legs (Influence of clearance between cilia of single leg on propulsion force)

  SHIRAI Atsushi; INOUE Kosuke; HAYASE Toshiyuki; SUDO Seiichi

  Transactions of the JSME (in Japanese) The Japan Society of Mechanical Engineers 82 (840) 16 - 00099-16-00099 2016/08 [Refereed]
   

  The goal of this study is elucidation of propulsion mechanism of small creatures by ciliated swimming legs. For this purpose, a ciliated pereiopod of an opossum shrimp was introduced and it was modeled with a straight cylindrical stem with 10 much narrower cylindrical poles perpendicularly projecting on the stem. Flow drag acting on the pereiopod in a steady flow, which corresponds to the thrust force by paddling of the pereiopod, was computed with a variety of clearance between each adjacent pair of cilia d and the flow velocity U. It was found that the drag increased with the increase in d to be saturated with a certain value in the range of d ≥ 0.04 mm where influence of boundary layers of adjacent cilia is negligible, and the drag agreed well with that estimated from drag of a two-dimensional cylinder. This result suggests that the opossum shrimp is propelled with the drag-based swimming and the ciliated pereiopods supply greater thrust force than tabular pereiopods with the same projection area. It was also found that the drag decreased in the range of d > 0.07 mm in which some cilia come into the boundary layer of body of the shrimp. It was optically observed that distance between adjacent cilia is around 0.07 mm on the stem and cilia near the root of the pereiopod are shorter than those near the tip. The present results suggest that the ciliated pereiopod is well designed to efficiently generate the thrust force within a limited length and mass by preventing influence of the boundary layers.

• Systematical Experiment for Optimal Design of Vibrating Flow Pump with Jelly-fish Valve

  Satoyuki Kawano; Saki Miyagawa; Atsushi Shirai

  Journal of Bionic Engineering SCIENCE PRESS 13 (1) 166 - 179 1672-6529 2016/01 [Refereed]
   

  The fundamental characteristics and the flow mechanism of a Vibrating Flow Pump (VFP) with a jelly-fish valve, which can be applied to a novel artificial heart, were studied theoretically and experimentally. By using water as the working fluid, the measurement methodology for the typical unsteady flow for VFP was developed here. The effects of the frequency, amplitude and inner diameter of the vibrating pipe, and thickness of the silicone rubber sheet of the jelly-fish valve on the basic performance of VFP were systematically investigated. A high-speed observation technique and simple theoretical model analysis were also introduced for further detailed discussion. Quantitative contributions of the individual parameters to the pumping performance were shown through the experiment, which would give us essential knowledge for establishing design criteria of VFP. The theoretical model, which agreed with the experiment and the high-speed observation, elucidated the pumping mechanism with respect to the role of inertia of the inner fluid.
• Fundamental study of interaction between erythrocyte and endothelial cell under inclined centrifugal force: Physical explanation of interaction model

  Akira Yatsuyanagi; Toshiyuki Hayase; Suguru Miyauchi; Kenichi Funamoto; Kosuke Inoue; Atsushi Shirai; Luca Brandt

  Proc. 12th International Conference on Flow Dynamics (ICFD2015) 320 - 321 2015/10
• Numerical reproduction of hemodynamic change induced by acupuncture needle stimulation to Taichong (LR-3): Modification of boundary conditions for quantitative agreement with experimental data

  Takuya Suzuki; Atsushi Shirai; Toshiyuki Hayase

  Proc. 12th International Conference on Flow Dynamics (ICFD2015) 316 - 317 2015/10
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelial topography

  Atsushi Shirai; Jean-Paul Rieu

  Proc. The 15th International Symposium on Advanced Fluid Information (AFI-2015) in ICFD2015 76 - 77 2015/10
• Numerical Reproduction of Hemodynamic Change Induced by Acupuncture to ST-36

  Takuya Suzuki; Atsushi Shirai; Takashi Seki

  Proc. 17th International Conference on Biological Engineering and Bionatural Sciences (ICBEBS 2015) 1718  2015/09
• A numerical study on the performance of micro-vibrating flow pumps using the immersed boundary method

  Osman Omran Osman; Atsushi Shirai; Satoyuki Kawano

  MICROFLUIDICS AND NANOFLUIDICS SPRINGER HEIDELBERG 19 (3) 595 - 608 1613-4982 2015/09 [Refereed]
   

  A micro-vibrating flow pump (micro-VFP) drives the fluid by the vibration of an elastic cantilever-like structure in the pump, which is actuated by a sinusoidal magnetic field. In the present study, we clarify the pumping mechanism of the micro-VFP through a numerical simulation. A two-dimensional simulation code based on the immersed boundary method was developed to obtain the flow field in the micro-VFP together with the vibration of the cantilever. The motion of the cantilever, which was imitated by the immersed body, was expressed as an external forcing term of the Navier-Stokes equations. Here, the magnetic force required to actuate the cantilever was calculated based on a two-dimensional magnetic model, and an integral approach was used to calculate the large deflection of the cantilever. The working conditions and length of the cantilever were numerically studied to determine their effects on the pumping performance. It was shown through the numerical simulations that the pumping mechanism could be explained as a result of elongation of the cantilever in the effective stroke induced by the actuating magnetic field. The pumping performance, which was characterized by the volumetric flow rate and the shut-off pressure, was enhanced by increasing the actuation frequency of the cantilever as has been found in previous experiments. It was also found that the cantilever has an optimum length to give the maximum flow rate. The mechanism was explained with respect to the kinetic energy transferred to the fluid by the vibrating cantilever and the choking level, which is determined by the clearance between the ceiling of the microchannel and the tip of the cantilever.
• On the Motility and Locomotive Organs of Beach Flea

  Seiichi Sudo; Takuya Amano; Atsushi Shirai; Toshiyuki Hayase

  Journal of Aero Aqua Bio-mechanisms 4 (1) 37 - 43 2015/08 [Refereed]
  
• Jumps of Water Springtail and Morphology of the Jumping Organ

  Seiichi Sudo; Toshiya Kainuma; Tetsuya Yano; Atsushi Shirai; Toshiyuki Hayase

  Journal of JSEM 15 (Special Issue) s117 - s124 2015/06 [Refereed]
  
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelium topography

  Jean-Paul Rieu; Atsushi Shirai

  2015 Annual ELyT Workshop Abstract Book USB-Memory  2015/02
• Numerical Analysis for Elucidation of Nonlinear Frictional Characteristics of a Deformed Erythrocyte Moving on a Plate in Medium Subject to Inclined Centrifugal Force

  Takashi Oshibe; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  Journal of Biomechanical Engineering-Transactions of the ASME ASME 136 (12) 121003  0148-0731 2014/12 [Refereed]
   

  Complex interactions between blood cells, plasma proteins, and glycocalyx in the endothelial surface layer are crucial in microcirculation. To obtain measurement data of such interactions, we have previously performed experiments using an inclined centrifuge microscope, which revealed that the nonlinear velocity-friction characteristics of erythrocytes moving on an endothelia-cultured glass plate in medium under inclined centrifugal force are much larger than those on plain or material-coated glass plates. The purpose of this study was to elucidate the nonlinear frictional characteristics of an erythrocyte on plain or material-coated glass plates as the basis to clarify the interaction between the erythrocyte and the endothelial cells. We propose a model in which steady motion of the cell is realized as an equilibrium state of the force and moment due to inclined centrifugal force and hydrodynamic flow force acting on the cell. Other electrochemical effects on the surfaces of the erythrocyte and the plate are ignored for the sake of simplicity. Numerical analysis was performed for a three-dimensional flow of a mixture of plasma and saline around a rigid erythrocyte model of an undeformed biconcave shape and a deformed shape with a concave top surface and a flat bottom surface. A variety of conditions for the concentration of plasma in a medium, the velocity of the cell, and the minimum gap width and the angle of attack of the cell from the plate, were examined to obtain the equilibrium states. A simple flat plate model based on the lubrication theory was also examined to elucidate the physical meaning of the model. The equilibrium angle of attack was obtained only for the deformed cell model and was represented as a power function of the minimum gap width. A simple flat plate model qualitatively explains the power function relation of the frictional characteristics, but it cannot explain the equilibrium relation, confirming the computational result that the deformation of the cell is necessary for the equilibrium. The frictional characteristics obtained from the present computation qualitatively agree with those of former experiments, showing the validity of the proposed model.
• On the motility and locomotive organs of beach flea

  Seiichi Sudo; Takuya Amano; Atsushi Shirai; Toshiyuki Hayase

  Proc. 6th International Symposium on Aero Aqua Bio-mechanisms (ISABME2014) 112 - 117 2014/11
• The jump of water springtail and morphology of the jumping organ

  Seiichi Sudo; Toshiya Kainuma; Tetsuya Yano; Atsushi Shirai; Toshiyuki Hayase

  Proc. 9th International Symposium on Advanced Science and Technology in Experimental Mechanics (9th ISEM'14) CD-ROM  2014/11
• Quantitative measurement of pulse waves using PVDF film sensor and cuff

  Yuta Wakabayashi; Atsushi Shirai

  Proc. 11th International Conference on Flow Dynamics (ICFD2014) 560 - 561 2014/10
• Fundamental study of interaction between erythrocyte and endothelial cell under inclined centrifugal force (Reproduction of friction characteristics by numerical analysis using simple interaction model)

  Akira Yatsuyanagi; Toshiyuki Hayase; Kenichi Funamoto; Kosuke Inoue; Atsushi Shirai

  Proc. 11th International Conference on Flow Dynamics (ICFD2014) 296 - 297 2014/10
• An aspect in flight morphology of the butterfly

  Seiichi Sudo; Ryosuke Tanaka; Kosuke Inoue; Atsushi Shirai; Toshiyuki Hayase

  Proc. 11th International Conference on Flow Dynamics (ICFD2014) 70 - 71 2014/10
• Simultaneous analysis system for blood pressure and flow using ultrasonic-measurement-integrated simulation

  Shusaku Sone; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  Proc. 7th World Congress of Biomechanics (WCB2014) #F5  2014/07
• 光電脈派計測と超音波計測融合解析による血圧血流同時計測システムによるWI解析

  曾根 周作; 早瀬 敏幸; 船本 健一; 白井 敦

  超音波医学 (公社)日本超音波医学会 41 (Suppl.) S480 - S480 1346-1176 2014/04
• Fundamental characteristics of motion of neutrophil-like HL-60 cells on glass plate

  Atsushi Shirai; Yoshiro Sugiyama

  2014 Annual ELyT Workshop Abstract Book USB-Memory  2014/02
• 2B26 Development of Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation : Evaluation of Wave Intensity Using Developed System

  Shusaku SONE; Toshiyuki HAYASE; Kenichi FUNAMOTO; Atsushi SHIRAI

  The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME Japan Society of Mechanical Engineers 2014.26 (0) 311 - 312 2014
• Influence of differentiation of HL-60 cells on their motion on a flat glass plate

  Yoshiro Sugiyama; Atsushi Shirai

  Proc. The 15th International Conference on Biomedical Engineering (ICBME 2013) #PO-03:20  2013/12
• Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation

  Shusaku Sone; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  Proc. The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'13) 1827 - 1830 2013/07 [Refereed]
  
• Friction characteristics of erythrocytes on endothelial-cultured or material-coated glass plates subject to inclined centrifugal forces

  Toshiyuki Hayase; Kosuke Inoue; Kenichi Funamoto; Atsushi Shirai

  Proc. 8th International Conference on Multiphase Flow (ICMF2013) 1 - 8 2013/05
• The Kinematics of Jumping of Globular Springtail

  Sudo Seiichi; Shiono Masahiro; Kainuma Toshiya; Shirai Atsushi; Hayase Toshiyuki

  J. Abmech Society of Aero Aqua Bio-mechanisms 3 (1) 85 - 91 2185-1522 2013/05 [Refereed]
   

  This paper describes jumping behaviour of the globular springtails. Direct observations on the jumping and climbing behaviour of springtails were conducted in the laboratory. The kinematics of jumping in tiny springtails was analyzed with high-speed video camera system. The vertical climbing behaviour was analyzed in contrast to the jumping behaviour. The jumping performance of springtails was revealed.
• Observations on the Springtail Leaping Organ and Jumping Mechanism Worked by a Spring

  Sudo Seiichi; Shiono Masahiro; Kainuma Toshiya; Shirai Atsushi; Hayase Toshiyuki

  J. Abmech Society of Aero Aqua Bio-mechanisms 3 (1) 92 - 96 2185-1522 2013/05 [Refereed]
   

  This paper is concerned with a small jumping mechanism. Microscopic observations of springtail leaping organs were conducted using a confocal leaser scanning microscope. A simple springtail mechanism using a spring and small electromagnet was produced based on the observations of leaping organ and the jumping analysis of the globular springtail. Jumping characteristics of the mechanism were examined with high-speed video camera system.
• Numerical Simulation of Passage of a Neutrophil through a Rectangular Channel with a Moderate Constriction

  Atsushi Shirai; Sunao Masuda

  PLOS ONE PUBLIC LIBRARY SCIENCE 8 (3) e59416  1932-6203 2013/03 [Refereed]
   

  The authors have previously presented a mathematical model to predict transit time of a neutrophil through an alveolar capillary segment which was modeled as an axisymmetric arc-shaped constriction settled in a cylindrical straight pipe to investigate the influence of entrance curvature of a capillary on passage of the cell. The axially asymmetric cross section of a capillary also influences the transit time because it requires three-dimensional deformation of a cell when it passes through the capillary and could lead to plasma leakage between the cell surface and the capillary wall. In this study, a rectangular channel was introduced, the side walls of which were moderately constricted, as a representative of axially asymmetric capillaries. Dependence of transit time of a neutrophil passing through the constriction on the constriction geometry, i.e., channel height, throat width and curvature radius of the constriction, was numerically investigated, the transit time being compared with that through the axisymmetric model. It was found that the transit time is dominated by the throat hydraulic diameter and curvature radius of the constriction and that the throat aspect ratio little affects the transit time with a certain limitation, indicating that if an appropriate curvature radius is chosen, such a rectangular channel model can be substituted for an axisymmetric capillary model having the same throat hydraulic diameter in terms of the transit time by choosing an appropriate curvature radius. Thus, microchannels fabricated by the photolithography technique, whose cross section is generally rectangular, are expected to be applicable to in vitro model experiments of neutrophil retention and passage in the alveolar capillaries.
• Motion of fMLP-Stimulated HL60 Cells on HUVEC Cultured on a Flat Glass Plate

  A. Shirai; H. Sato; T. Hayase

  Surface Modification Technologies 26 83 - 91 2013/02 [Refereed]
  
• 植物表面細胞の形状計測－植物流体力学的アプローチ－

  須藤誠一; 塩野正裕; 白井敦; 早瀬敏幸

  実験力学 12 (4) 338 - 343 2012/12 [Refereed]
  
• Numerical analysis of leviation mechanism of red blood cell in inclined centrifuge microscope - Effect of asymmetric cell shape on the motion

  Takashi Oshibe; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  Proc. Ninth International Conference on Flow Dynamics (ICFD2012) 756 - 757 2012/09
• The jump of the globular springtail and jumping mechanism worked by a spring

  Seiichi Sudo; Masahiro Shiono; Atsushi Shirai; Toshiyuki Hayase

  Proc. The 5th International Symposium on Aero Aqua Bio-mechanisms (ISABMEC2012) 66 - 73 2012/08
• Dynamics in motion of dandelion flower head

  Seiichi Sudo; Masahiro Shiono; Atsushi Shirai; Toshiyuki Hayase

  Proc. 15th International Conference on Experimental Mechanics (ICEM15) #2629  2012/07
• Influence of Pressing Force on Motion of HL60 Cells on HUVEC substrate

  A. Shirai; H. Uranuma; T. Hayase

  Journal of Biomechanics (Proc. 18th Congress of the European Society of Biomechanics (ESB2012)) 45 (1) S41  2012/07
• Motion of fMLP-stimulated HL60 cells on HUVEC cultured on a flat glass plate

  A. Shirai; H. Sato; T. Hayase

  Proc. 26th International Conference on Surface Modification Technologies (SMT26) 39 - 40 2012/06
• Behavior of HL60 cells on a HUVEC substrate under inclined centrifugal forces

  Atsushi Shirai; Haruka Uranuma; Toshiyuki Hayase

  2012 Annual ELyT Workshop Abstract Book USB-Memory  2012/03
• Contribution of ulnar artery to numerical reproduction of indentation experiment of radial artery for scientific verification of pulse diagnosis

  Minoru Takashima; Atsushi Shirai; Toshiyuki Hayase

  Proc. 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering 84 - 85 2011/12
• Numerical analysis for the effect of angle of attack on a red blood cell moving in an inclined centrifuge microscope

  Takashi Oshibe; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  Proc. 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering 82 - 83 2011/12
• Springtail jump on water surface

  Toshiya Kainuma; Seiichi Sudo; Atsushi Shirai; Toshiyuki Hayase

  Proc. Eighth International Conference on Flow Dynamics (ICFD2011) #CRF-37  2011/11
• Observation of fly wings and flight behavior

  Kohei Kitadera; Seiichi Sudo; Atsushi Shirai; Toshiyuki Hayase

  Proc. Eighth International Conference on Flow Dynamics (ICFD2011) 154 - 155 2011/11
• Movement of springtail in air

  M. Shiono; S. Sudo; A. Shirai; T. Hayase

  Proc. Eighth International Conference on Flow Dynamics (ICFD2011) 152 - 153 2011/11
• Numerical analysis of one-dimensional mathematical model of blood flow to reproduce fundamental pulse wave measurement for scientific verification of pulse diagnosis

  Atsushi Shirai; Tsutomu Nakanishi; Toshiyuki Hayase

  Journal of Biomechanical Science and Engineering 6 (4) 330 - 342 1880-9863 2011/11 [Refereed]
   

  Pulse diagnosis in traditional Chinese medicine is said to be able to detect not only illness but also decline of health in the patients from tactile sense of the pulse in the radial artery at the wrists. This diagnosis, however, is not supported by concrete scientific evidence. The authors have proposed a non-linear spring model of subcutaneous tissue on the radial artery and one-dimensional arterial blood flow model in an arm for the purpose of scientific verification of the pulse diagnosis. They performed, in the former study, a numerical experiment with this mathematical model in which the radial artery was indented in a stepwise manner by a pressure sensor, which extract the fundamental mechanism of the pulse diagnosis, to validate the subcutaneous tissue model and to find the appropriate coefficient to fit the experimental result. They investigated, in this research, contribution of parameters of supply pressure of the blood and tube law of the artery on the change in the pressure pulse waves with the indentation steps with respect to mean value P oav and amplitude ΔP o of the pressure. It was shown that mean supply pressure affects both P oav and ΔP o, while amplitude of the supply pressure affects ΔP o. It was also shown that profile of ΔP o vs. distance of the indentation changes drastically as the artery becomes hard. Lastly, it was examined to reproduce the experimentally obtained pressure pulse waves during the indentation in their former work with the mathematical model by adjusting the parameters. The result showed better agreement than the former result, but it implied that ulnar artery had to be taken into consideration for quantitative fitting of the pulse waves to the range where the radial artery was nearly flattened by the indentation. © 2011 by JSME.
• Some Locomotion Modes of Small Aquatic and Beach Creatures

  SUDO Seiichi; HOSHIKA Kyohei; SHIRAI Atsushi; HAYASE Toshiyuki

  Journal of JSEM 日本実験力学会 11 (2) 91 - 100 1346-4930 2011/06 [Refereed]
  
• Observation of motion of HL60 cells on HUVEC cultured on a flat glass plate using the inclined centrifuge microscope

  Atsushi Shirai; Takashi Umimoto; Haruka Uranuma; Toshiyuki Hayase

  The 3rd ELyT lab Workshop Abstract Book USB-Memory  2011/02
• Observation of velocity of antibody-modified HL60 cells on glass plates using the inclined centrifuge microscope

  Hiroki Sato; Atsushi Shirai; Toshiyuki Hayase

  Proc. 4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering 62 - 63 2010/12
• Stabilization of Measurement-Integrated Simulation by Elucidation of Destabilizing Mechanism

  HAYASE Toshiyuki; IMAGAWA Kentaro; FUNAMOTO Kenichi; SHIRAI Atsushi

  JFST The Japan Society of Mechanical Engineers 5 (3) 632 - 647 1880-5558 2010/12 [Refereed]
   

  Measurement-integrated (MI) simulation is a numerical flow analysis method with a feedback mechanism from measurement of a real flow. It correctly reproduces a real flow under inherent ambiguity in a mathematical model or a computational condition. In this paper we theoretically investigated the destabilization phenomenon of MI simulation, in which analysis error suddenly increases at some critical feedback gain. This phenomenon has been considered as instability of a closed-loop feedback system, but present study treated it as that of a numerical scheme. First, the mechanism of the destabilization phenomenon was investigated based on the sufficient condition of the convergence of iterative calculation of existing MI simulation. It was found that the feedback signal in the source term destabilized the iterative calculation. Then, a new MI simulation scheme was derived by evaluating the feedback signal in the linear term to remove the cause of the destabilization. The validity of the present theoretical analysis was verified for examples treated in former studies of MI simulations: blood flow in an aneurismal aorta with ultrasonic measurement, blood flow in a cerebral aneurism with magnetic resonance measurement, Karman vortex street behind a square cylinder with PIV measurement, and fully developed turbulent flow in a square duct with ideal measurement. Occurrences of destabilization phenomenon in all the examples were well explained by the condition of this study, especially for cases of relatively small time steps and large feedback gains. Furthermore, the new MI simulation scheme realized the analysis without the destabilization phenomenon. The present theoretical result confirming that the destabilization phenomenon is not the instability of the feedback system but that of a numerical scheme is generally applicable to MI simulations using the velocity error for the feedback signal.
• Experimental study on effect of direction of endothelial cells' orientation on motion of HL60 cells

  H. Uranuma; A. Shirai; T. Hayase

  Proc. Seventh International Conference on Flow Dynamics (ICFD 2010) 629 - 621 2010/11
• A stabilization technique of wobbly images taken by the inclined centrifuge microscope

  A. Shirai; T. Hayase

  Proc. 6th World Congress of Biomechanics (WCB2010) 1570 - 1573 2010/08 [Refereed]
  
• An aligning technique of successive images taken by the inclined centrifuge microscope

  Atsushi Shirai

  2010 Annual ELyT Workshop Abstract Book 2010/03
• Experimental observation of behavior of neutrophil-like HL60 cells on oriented endothelial cells

  Haruka Uranuma; Atsushi Shirai; Toshiyuki Hayase

  Proc. 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering 22 - 23 2009/12
• Numerical simulation of distribution of neutrophils in a lattice alveolar capillary network

  Atsushi Shirai; Toshiyuki Hayase

  Respiratory Physiology & Neurobiology ELSEVIER SCIENCE BV 165 (2-3) 143 - 153 1569-9048 2009/02 [Refereed]
   

  Neutrophils are known to be retained in narrow pulmonary capillaries, even in normal lungs, due to their low deformability, resulting in a higher concentration than that in systemic circulation. In this study, to obtain a fundamental understanding of the behavior of neutrophils, we simplified an alveolar capillary network to a rectangular grid of short capillary segments and numerically investigated the flow of a suspension of neutrophils and plasma through the capillary network for various concentrations of the suspension, C(sus), injected into the network. The cells traveled limited preferential paths in the network while C(sus) was low. Retention of a cell or cells induced plugging of the segment with a cessation of blood flow, and as the result of the changed plasma flow field caused by such plugging, the cells took various routes differing from the preferential paths. A low incidence of plugging helped to accelerate the cells flowing in the network with tight segments, resulting in a decrease in their mean transit time through the network as compared with the case of a single-cell transit. On the contrary, however, an increasing incidence of plugging induced backward motion of the cells and a resultant increase in the mean transit time. The time-averaged number of cells in the network increased with the increase in C(sus), and the fractional residence time of cells in individual segments approached a constant. This means that a high concentration of neutrophils facilitates their uniform distribution in the network. However, the ratio between the time-averaged concentration of the cells in the network and C(sus) decreased and our numerical simulation did not reach the experimentally obtained value. This implies that, in a real alveolar capillary bed, plasma leaks through the plugged segments or that the capillary network has bypasses through which the plasma can flow. (C) 2008 Elsevier B.V. All rights reserved.
• Measurement of friction characteristics of neutrophils on MPC polymer with the inclined centrifuge microscope

  Takashi Umimoto; Atsushi Shirai; Toshiyuki Hayase

  Proc. GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering 11 - 12 2008/12
• Reproduction of pulse waveform measurement using one-dimensional mathematical model for validation of pulse diagnosis

  Tsutomu Nakanishi; Atsushi Shirai; Toshiyuki Hayase

  Proc. GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering 9 - 10 2008/12
• Frictional characteristics of erythrocytes on coated glass plates subject to inclined centrifugal forces

  Takashi Kandori; Toshiyuki Hayase; Kousuke Inoue; Kenichi Funamoto; Takanori Takeno; Makoto Ohta; Motohiro Takeda; Atsushi Shirai

  Journal of Biomechanical Engineering-Transactions of the ASME ASME-AMER SOC MECHANICAL ENG 130 (5) 051007-1 - 051007-8 0148-0731 2008/10 [Refereed]
   

  In recent years a diamond-like carbon (DLC) film and a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer have attracted attention as coating materials for implantable artificial organs or devices. When these materials are coated on vascular devices, compatibility to blood is an important problem. The present paper focuses on friction characteristics of erythrocytes to these coating materials in a medium. With an inclined centrifuge microscope developed by the authors, observation was made for erythrocytes moving on flat glass plates with and without coating in a medium of plasma or saline under the effect of inclined centrifugal force. Friction characteristics of erythrocytes with respect to these coating materials were then measured and compared to each other to characterize DLC and MPC as coating materials. The friction characteristics of erythrocytes in plasma using the DLC-coated and noncoated glass plates are similar, changing approximately proportional to the 0.5th power of the cell velocity. The cells stick to these plates in saline as well, implying the influence of plasma protein. The results using the MPC-coated plate in plasma are similar to those of the other plates for large cell velocities, but deviate from the other results with decreased cell velocity. The results change nearly proportional to the 0.75th power of the cell velocity in the range of small velocities. The results for the MPC-coated plate in saline are similar to that in plasma but somewhat smaller, implying that the friction characteristics for the MPC-coated plate are essentially independent of plasma protein.
• Development of one-dimensional mathematical model for validation of pulse diagnosis

  Kentaro NARUMI; Tsutomu NAKANISHI; Atsushi SHIRAI; Toshiyuki HAYASE

  日本機械学会論文集(B編) 74 (737) 142 - 148 2008/01 [Refereed]
  
• Effect of Retention Time of Neutrophils in Alveolar Capillaries on Increase in Their Concentration in the Capillary Network

  Atsushi Shirai; Toshiyuki Hayase

  Proc. 5th Joint ASME/JSME Fluids Engineering Conference (FEDSM2007) #FEDSM2007-37654  2007/07 [Refereed]
  
• Effect of Neutrophils Retention Time in Capillaries on Increase in Their Concentration in a Lattice Capillary Network Model

  Atsushi Shirai; Toshiyuki Hayase

  Proc. ASME 2007 Summer Bioengineering Conference #SBC2007-176717  2007/06
• Deformations of thin liquid spherical shells in liquid-liquid-gas systems

  Satoyuki Kawano; Atsushi Shirai; Shohei Nagasaka

  Physics of Fluids AMER INST PHYSICS 19 (1) Article 012105  1070-6631 2007/01 [Refereed]
   

  Deformation characteristics of a millimeter-sized thin liquid spherical shell moving at intermediate Reynolds numbers in immiscible liquid are investigated both numerically and experimentally. Experiments are made using the novel principle of sequential production of the shell developed by the authors. Numerical results of the flow pattern around the liquid shell, deformation ratio, and the drag coefficient are compared to experimental results for wide flow conditions. They are in reasonable agreement from the viewpoint of practical engineering. Furthermore, effects of shell deformation on heat transfer characteristics are also investigated numerically. The present research provides the fluid dynamical knowledge for various applications of liquid spherical shells. (c) 2007 American Institute of Physics.
• Numerical simulation of flow for viscoelastic neutrophil models in a rectangular capillary network: Effects of capillary shape and cell stiffness on transit time

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Technology and Health Care 15 (2) 131 - 146 0928-7329 2007 [Refereed]
   

  The concentration of neutrophils in the pulmonary microvasculature is higher than in large systemic vessels. It is thought that the high concentration of neutrophils facilitates their effective recruitment to sites of inflammation. Thus, in order to understand the role of neutrophils in the immune system, it is important to clarify their flow characteristics in the pulmonary microvasculature. In a previous study, we developed a model to simulate the flow of neutrophils in a capillary network, in which the cells were modeled as spheres of a Maxwell material with a cortical tension and the capillary segments were modeled as arc-shaped constrictions in straight pipes. In the present paper, the flow of neutrophils in a simplified alveolar capillary network model is investigated for various constriction shapes and cell stiffnesses. Finally, it is shown that both the coefficient of variation of the transit time of the cells, which is the standard deviation divided by the mean transit time, and the mean transit time increase as the capillary segments become steep or tight, or when the cells become hard. The mean value of the transit time exceeds the median for all of the conditions that occur in real lungs, although the difference between them is small. © 2007 - IOS Press and the authors. All rights reserved.
• Numerical simulation of noninvasive blood pressure measurement

  Satoru Hayashi; Toshiyuki Hayase; Atsushi Shirai; Masaru Maruyama

  Journal of Biomechanical Engineering-Transactions of the ASME ASME-AMER SOC MECHANICAL ENG 128 (5) 680 - 687 0148-0731 2006/10 [Refereed]
   

  In this paper a simulation model based on the partially pressurized collapsible tube model for reproducing noninvasive blood pressure measurement is presented. The model consists of a collapsible tube, which models the pressurized part of the artery, rigid pipes connected to the collapsible tube, which model proximal and distal region far from the pressurized part, and the Windkessel model, which represents the capacitance and the resistance of the distal part of the circulation. The blood flow is simplified to a one-dimensional system. Collapse and expansion of the tube is represented by the change in the cross-sectional area of the tube considering the force balance acting on the tube membrane in the direction normal to the tube axis. They are solved using the Runge-Kutta method. This simple model can easily reproduce the oscillation of inner fluid and corresponding tube collapse typical for the Korotkoff sounds generated by the cuff pressure. The numerical result is compared with the experiment and shows good agreement.
• Numerical simulation of 3-D deformation of a neutrophil in a rectangular microchannel

  Atsushi SHIRAI; Sunao MASUDA; Toshiyuki HAYASE

  Journal of Biomechanics (Abstract of the 5th World Congress of Biomechanics) S333 - CD-ROM 2006/07
• 3-D numerical simulation of flow of a neutrophil for the retention time in a moderate constriction of a rectangular microchannel

  Atsushi Shirai; Sunao Masuda; Toshiyuki Hayase

  Proc. ASME 2006 Summer Bioengineering Conference #157817  2006/06
• Numerical realization of blood flow in aneurysmal aorta by integrating measurement and simulation

  Hayase, Toshiyuki; Funamoto, Kenichi; Yamagata, Takayuki; Liu, Lei; Shirai, Atsushi; Ohta, Makoto; Inoue, Kosuke; Saijo, Yoshifumi; Yambe, Tomoyuki

  Future Medical Engineering Based on Bionanotechnology, Proceedings 2006 [Refereed]
  
• Numerical Simulation of Flow and Deformation of a Neutrophil Passing Through a Constriction in a Fine Capillary

  Atsushi SHIRAI; Ryo FUJITA; Toshiyuki HAYASE

  Reports of the Institute of Fluid Science, Tohoku University 18 2006 

  Published in the Proc. 5th JSME-KSME Fluid Eng. Conf., (2002).
• Moderate constriction model for neutrophils flow in pulmonary capillaries

  A. Shirai

  Proc. The 12th International Conference on Biomedical Engineering (ICBME2005) 74  2005/12 [Invited]
  
• Moderate constriction model for neutrophils flow in pulmonary capillaries

  A. Shirai; R. Fujita; T. Hayase

  Proc. The 7th International Symposium of Future Medical Engineering based on Bio-nanotechnology 8 - 11 2005/12
• Numerical analysis of effect of cross-section of microchannel on transit characteristics of neutrophils

  Sunao Masuda; Atsushi Shirai; Toshiyuki Hayase

  Proc. The 5th International Symposium on Advanced Fluid Information(AFI-2005) 64 - 65 2005/12
• Numerical Simulation for Spatial Distribution of Neutrophils in a Capillary Network

  Atsushi Shirai; Toshiyuki Hayase

  Proc. The 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program) 60 - 61 2005/11
• Three-dimensional numerical analysis of plasma flow around a neutrophil in a microchannel

  Atsushi Shirai; Sunao Masuda; Toshiyuki Hayase

  Proc. ASME 2005 Summer Bioengineering Conference #b0105636  2005/06
• Fundamental study of ultrasonic-measurement-integrated simulation of real blood flow in the aorta

  K Funamoto; T Hayase; A Shirai; Y Saijo; T Yambe

  Annals of Biomedical Engineering SPRINGER 33 (4) 415 - 428 0090-6964 2005/04 [Refereed]
   

  Acquisition of detailed information on the velocity and pressure fields of the blood flow is essential to achieve accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms. A possible way to obtain such information is integration of numerical simulation and color Doppler ultrasonography in the framework of a flow observer. This methodology, namely, Ultrasonic-Measurement-Integrated (UMI) Simulation, consists of the following processes. At each time step of numerical simulation, the difference between the measurable output signal and the signal indicated by numerical simulation is evaluated. Feedback signals are generated from the difference, and numerical simulation is updated applying the feedback signal to compensate for the difference. This paper deals with a numerical study on the fundamental characteristics of UMI simulation using a simple two-dimensional model problem for the blood flow in an aorta with an aneurysm. The effect of the number of feedback points and the feedback formula are investigated systematically. It is revealed that the result of UMI simulation in the feedback domain rapidly converges to the standard solution, even with usually inevitable incorrect upstream boundary conditions. Finally, an example of UMI simulation with feedback from real color Doppler measurement also shows a good agreement with measurement.
• Flow simulation of neutrophils in capillary network (Effect of capillary geometry on transit time of cells through network)

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Proc. The 3rd IASTED International Conference BIOMEDICAL ENGINEERING (BioMED 2005) 929 - 934 2005/02 [Refereed]
  
• Numerical realization for analysis of real flows by integrating computation and measurement

  T Hayase; K Nisugi; A Shirai

  International Journal for Numerical Methods in Fluids JOHN WILEY & SONS LTD 47 (6-7) 543 - 559 0271-2091 2005/02 [Refereed]
   

  In this paper, we deal with a numerical realization, which is a numerical analysis methodology to reproduce real flows by integrating numerical simulation and measurement. It is difficult to measure or calculate field information of real three-dimensional unsteady flows due to the lack of an experimental field measurement method, as well as of a way to specify the exact boundary or initial conditions in computation. Based on the observer theory, numerical realization is achieved by a combination of numerical simulation, experimental measurement, and a feedback loop to the simulation from the output signals of both methods. The present paper focuses on the problem of how an inappropriate model or insufficient grid resolution influences the performance of the numerical realization in comparison with ordinary simulation. For a fundamental flow with the Karman vortex street behind a square cylinder, two-dimensional analysis is performed by means of numerical realization and ordinary simulation with three grid resolutions. Comparison of the results with those of the experiment proved that the feedback of the experimental measurement significantly reduces the error due to insufficient grid resolution and effectively reduces the error due to inappropriate model assuming two-dimensionality. Copyright (C) 2004 John Wiley Sons, Ltd.
• Simulation model for flow of neutrophils in pulmonary capillary network

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Technology and Health Care 13 (4) 301 - 311 0928-7329 2005 [Refereed]
   

  The concentration of neutrophils in the pulmonary microvasculature is higher than in systemic large vessels. It is thought that the high concentration of neutrophils facilitates their effective recruitment to sites of inflammation. Thus, in order to understand the role of neutrophils in the immune system, it is important to clarify their flow characteristics in the pulmonary microvasculature. In previous studies, we numerically investigated the motion of a neutrophil through a single capillary segment modeled by a moderate axisymmetric constriction in a straight pipe, developing a mathematical model for the prediction of the transit time of the cell through the segment. In the present study, this model was extended for application to network simulation of the motion of neutrophils. First, we numerically investigated shape recovery of a neutrophil after expulsion from a narrow capillary segment. This process was modeled in two different phases: elastic recovery and viscous recovery. The resulting model was combined with the previously developed models to simulate motion of the cells and plasma flow in a capillary network. A numerical simulation of the motion of neutrophils and plasma flow in a simple lattice capillary network showed that neutrophils were widely dispersed in the network with an increased concentration. © 2005 - IOS Press and the authors. All rights reserved.
• Effect of Cell Stiffness on Transit Through Pulmonary Capillary Network

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Proc. The 4th International Symposium on Advanced Fluid Information and The 1st International Symposium on Transdisciplinary Fluid Integration (AFI/TFI 2004) 26 - 29 2004/11
• Fundamental study of aerodynamic drag reduction for vehicle with feedback flow control

  K Nisugi; T Hayase; A Shirai

  JSME International Journal Series B JAPAN SOC MECHANICAL ENGINEERS 47 (3) 584 - 592 1340-8054 2004/08 [Refereed]
   

  The present paper deals with a fundamental study of aerodynamic drag reduction for a vehicle with a feedback flow control. As the first step, two-dimensional calculation was performed for a flow around a simplified vehicle model. The mechanism of unsteady drag was investigated in relation to the vortex shedding from the model. The location of the control flow nozzle was so determined that the control flow influences the drag most effectively. The key in designing the present feedback control is the definition of the output signal. Based on the physical consideration of the drag generation, the location of the output velocity measurement was changed within a limited region near the front windshield. A systematic calculation revealed that the output signal defined in a small region results in a significant drag reduction of 20% with respect to the case without control. The present feedback flow control is generally applicable to the drag reduction of the bluff body for which the drag is generated under the same mechanism of essentially two-dimensional vortex shedding.
• Fundamental study of hybrid wind tunnel integrating numerical simulation and experiment in analysis of flow field

  K Nisugi; T Hayase; A Shirai

  JSME International Journal Series B JAPAN SOC MECHANICAL ENGINEERS 47 (3) 593 - 604 1340-8054 2004/08 [Refereed]
   

  This paper deals with a new flow analysis system, namely the hybrid wind tunnel, which integrates the experimental measurement with a wind tunnel and a corresponding numerical simulation with a computer. Analysis here is performed for the fundamental flow with the Karman vortex street in a wake of a square cylinder. A specific feature of the hybrid wind tunnel is existence of the feedback signal to compensate the error in the pressure on the side walls of the cylinder and the feed-forward signal to adjust the upstream velocity boundary condition. Investigation is focused on evaluating the hybrid wind tunnel as a flow analysis methodology with respect to the ordinary simulation and the experiment. As compared with the ordinary simulation, the hybrid wind tunnel substantially improves the accuracy and the efficiency in the analysis of the flow. Especially, the oscillation of the flow due to the Karman vortex street reproduced with the hybrid wind tunnel exactly synchronizes with that of the experiment; while that with the ordinary simulation never behave like that. In comparison with the experiment, the hybrid wind tunnel provides more detailed information of the flow than the experiment does.
• Development of a Measurement System of Blood Cell Velocities in Microchannels

  Sunao Masuda; Atsushi Shirai; Toshiyuki Hayase

  Proc. The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program) 88 - 89 2004/06
• Application of Ultrasonic-Measurement-Integrated Simulation to Blood Flow

  Kenichi Funamoto; Toshiyuki Hayase; Atsushi Shirai; Yoshifumi Saijo; Tomoyuki Yambe

  Proc. The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program) 78 - 79 2004/06
• Flow Simulation of Neutrophils in Pulmonary Capillary Network

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Proc. The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program) 28 - 29 2004/06
• Two-dimensional computational flow analysis and frictional characteristics model for red blood cell under inclined centrifuge microscopy

  K Funamoto; T Hayase; A Shirai

  JSME International Journal Series C JAPAN SOC MECHANICAL ENGINEERS 46 (4) 1304 - 1311 1344-7653 2003/12 [Refereed]
   

  Simplified two-dimensional flow analysis is performed in order to simulate frictional characteristics measurement of red blood cells moving on a glass plate in a medium with an inclined centrifuge microscope. Computation under various conditions reveals the influences of parameters on lift, drag, and moment acting on a red blood cell. Among these forces, lift appears only when the cell is longitudinally asymmetric. By considering the balance of forces, the frictional characteristics of the red blood cell are modeled as the sum of Coulomb friction and viscous drag. The model describes the possibility that the red blood cell deforms to expand in the front side in response to the inclined centrifugal force. When velocity exceeds some critical value, the lift overcomes the normal centrifugal force component, and the thickness of the plasma layer between the cell and the glass plate increases from the initial value of the plasma protein thickness.
• Transit characteristics of a neutrophil passing through two moderate constrictions in a cylindrical capillary vessel (Effect of cell deformation on transit through the second constriction)

  A Shirai; R Fujita; T Hayase

  JSME International Journal Series C JAPAN SOC MECHANICAL ENGINEERS 46 (4) 1198 - 1207 1344-7653 2003/12 [Refereed]
   

  Neutrophils must flow through the pulmonary capillary network in a deformed shape because pulmonary capillaries are closely interconnected, and deformed neutrophils take about 15 s to 1 min to return to their resting spherical shape. In this paper, flow of a neutrophil through two moderate constrictions in a pipeline is numerically investigated, focusing on the effect of cell deformation on the cell's transit time through the constrictions. Changing sizes and positions of the constrictions, we found that the maximum cell radius at the entrance of the constriction and the throat radius of the constriction are the dominant factors in predicting the cell's transit time through the constriction. When the difference between these two radii is relatively large, steeper constriction (smaller radius of curvature) increases the transit time, but this tendency is reversed when the difference is small. Cells traverse the constriction without delay when the maximum cell radius and throat radius are comparable. Finally, we present a simple mathematical model for the transit time.
• Transit Characteristics of a Deformed Neutrophil Through a Moderate Constriction

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Proc. 2003 ASME International Mechanical Engineering Conference (IMECE2003) #IMECE2003-55020  2003/11
• Numerical Analysis for Affect of Neutrophil Shape on Transit Through Capillaries

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Proc. 3rd International Symposium on Advanced Fluid Information (AFI-2003) 41 - 42 2003/11
• Reproduction of Real Blood Flow in Aorta with Ultra sonic-Measurement-Integrated Simulation

  Kenichi Funamoto; Toshiyuki Hayase; Atsushi Shirai; Tomoyuki Yambe; Yoshifumi Saijo

  Proc. 3rd International Symposium on Advanced Fluid Information (AFI-2003) 39 - 40 2003/11
• Numerical simulation of noninvasive blood pressure measurement by partially pressurized collapsible tube model

  Satoru Hayashi; Masaru Maruyama; Toshiyuki Hayase; Atsushi Shirai

  Proc. 7th International Symposium on Fluid Control, Measurement and Visualization (FLUCOME 2003) #023  2003/08
• Evidence-based Simulation of Blood Flow with Feedback of Ultrasonic Measurement

  Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai; Tomoyuki Yambe; Yoshifumi Saijo

  Proc. The 1st International Symposium on Future Medical Engineering based on Bio-nanotechnology 40 - 42 2003/01
• Numerical Realization of Flow by Integrating Computation and Measurement in Medical Applications

  Toshiyuki Hayase; Kenichi Funamoto; Keisuke Nisugi; Atsushi Shirai; Tomoyuki Yambe; Yoshifumi Saijo

  Proc. AFI-2002 Mini-Symposium on Advanced Fluid Information - Fusion of EFD and CFD 77 - 85 2002/12
• Transit characteristics of a neutrophil passing through a circular constriction in a cylindrical capillary vessel (effect of mechanical properties of the cell and constriction geometry)

  A Shirai; R Fujita; T Hayase

  JSME International Journal Series C JAPAN SOC MECHANICAL ENGINEERS 45 (4) 974 - 980 1344-7653 2002/12 [Refereed]
   

  The former analysis of neutrophil's transit through pulmonary capillary network used the result of a micropipette aspiration experiment to model the transit in single capillary segment despite blunt tip geometry of the pipette is largely different from the real capillary segment. In the previous work, we have numerically investigated the transit of passive and fMLP-stimulated neutrophils through an arc-shaped constriction, establishing the analytical expression for the transit time. This paper intends to give a simplified model for the transit of a neutrophil through a capillary segment based on the numerical analysis and the stress-strain relationship of a Maxwell material. It is shown that the transit time is in proportion to the viscosity of the cell and in inverse proportion to the square root of the curvature radius of the constriction. The definition of the driving pressure of the cell into a micropipette is also applicable to that into the constriction.
• Flow and deformation of a neutrophil passing through a constriction in a fine capillary

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Proc. The 5th JSME-KSME Fluids Engineering Conference CD-ROM  2002/11
• Analysis of Dynamic Characteristics of Water Hydraulic Relief Valve

  林叡; 中西貴之; 早瀬敏幸; 白井敦

  日本フルードパワーシステム学会論文集 33 (7) 149 - 155 2002/11 [Refereed]
  
• Neutrophil transit times through pulmonary capillaries: The effects of capillary geometry and fMLP-stimulation

  M Bathe; A Shirai; CM Doerschuk; RD Kamm

  Biophysical Journal BIOPHYSICAL SOCIETY 83 (4) 1917 - 1933 0006-3495 2002/10 [Refereed]
   

  The deformations of neutrophils as they pass through the pulmonary microcirculation affect their transit time, their tendency to contact and interact with the endothelial surface, and potentially their degree of activation. Here we model the cell as a viscoelastic Maxwell material bounded by constant surface tension and simulate indentation experiments to quantify the effects of (N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-stimulation on its mechanical properties (elastic shear modulus and viscosity). We then simulate neutrophil transit through individual pulmonary capillary segments to determine the relative effects of capillary geometry and fMLP-stimulation on transit time. Indentation results indicate that neutrophil viscosity and shear modulus increase by factors of 3.4, for 10(-9) M fMLP, and 7.3, for 10(-6) M fMLP, over nonstimulated cell values, determined to be 30.8 Pa.s and 185 Pa, respectively. Capillary flow results indicate that capillary entrance radius of curvature has a significant effect on cell transit time, in addition to minimum capillary radius and neutrophil stimulation level. The relative effects of capillary geometry and fMLP on neutrophil transit time are presented as a simple dimensionless expression and their physiological significance is discussed.
• Effect of constriction geometry on transit of deformed neutrophils in capillaries

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Proc. 4th World Congress of Biomechanics (WCB2002) CD-ROM  2002/08
• Numerical realization of flow field by integrating computation and measurement

  Toshiyuki Hayase; Keisuke Nisugi; Atsushi Shirai

  Proc. 5th World Congress on Computational Mechanics (WCCM V) 1 - 12 2002/07
• Three-dimensional flow analysis in VFP type artificial heart by unstructured grid

  Satoyuki Kawano; Takuma Kato; Kazuhiro Nakahashi; Atsushi Shirai; Toshiyuki Hayase; Tomoyuki Yambe; Shin-Ichi Nitta; Hiroyuki Hashimoto

  American Society of Mechanical Engineers, Pressure Vessels and Piping Division (Publication) PVP 448 (1) 229 - 238 0277-027X 2002 [Refereed]
   

  To effectively design the vibrating flow pump (VFP) for left ventricular assist device, the numerical codes were developed for three-dimensional blood flow based on the finite volume method. The numerical codes were also developed based on the artificial compressibility method by the use of unstructured grid. Three-dimensional numerical computations and the visualizations were made for flow patterns in the casing of VFP, which were closely connected with hemolysis and blood coagulation. We examined the three different inlet conditions, i.e., radial flow, flow considering the 2nd vibration mode of the jellyfish valve motion, and the swirling flow, to explore the suitable condition for preventing the hemolysis and the blood coagulation. It was found that the swirling flow could effectively decrease hemolysis. The effect of rhenlogy model of the blood flow was also studied in detail.
• Measurement of frictional characteristics of red blood cells moving on a plate in plasma due to inclined centrifugal force

  Toshiyuki Hayase; Atsushi Shirai; Hidekatsu Sugiyama; Tsuyoshi Hamaya

  Nippon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B Japan Society of Mechanical Engineers 68 (676) 3386 - 3391 0387-5016 2002 [Refereed]
   

  As a fundamental equipment for studying blood flow in microcirculation, the inclined centrifuge microscope enables us to measure frictional characteristics of cells moving on a plate in a medium under the effect of inclined centrifugal force. Specifically, this paper deals with measurement for red blood cells moving on a glass plate in plasma. First, accuracy of the manual measurement of cell velocity through the microscope was confirmed in comparison with the image processing method. Measurement was then performed confirming frictional characteristics of red blood cells were properly modeled as the sum of the Coulomb friction with friction coefficient of 0.206 and the linear viscous friction applied on a simplified circular disk with a plasma layer of thickness of 0.176 μm in the present condition.
• Multi-Scale Simulation in biological Systems

  Roger Kamm; Eun-Bo Shim; Atsushi Shirai; Mark Bathe; Thomas Heldt; Hesham Younis; Ana Isasi; Mohammad Kaazempur-Mofrad; Wonmuk Hwang

  Proc. The 1st International Symposium on Advanced Fluid Information (AFI-2001) 121 - 124 2001/10
• The Effect of Neutrophil Activation on Transit Time through Pulmonary Capillaries

  Atsushi Shirai; Mark Bathe; Roger D. Kamm

  Proc. The 1st International Symposium on Advanced Fluid Information (AFI-2001) 125 - 130 2001/10
• Static and dynamic characteristics of a pressure-compensated flow control

  Satoru Hayashi; Atsushi Shirai; Nan-nan Guo; Toshiyuki Hayase

  Proc. The 5th International Conference on Fluid Power Transmission and Control (ICFP'2001) 156 - 160 2001/04 [Refereed]
  
• Influence of Pipeline Friction on Chaotic Oscillations in a Direct-Acting Poppet Valve Circuit

  HAYASHI Satoru; WANG Weimin; HAYASE Toshiyuki; SHIRAI Atsushi

  TRANSACTIONS OF THE JAPAN FLUID POWER SYSTEM SOCIETY The Japan Fluid Power System Society 31 (5) 123 - 131 1343-4616 2000/08 [Refereed]
   

  Poppet valve circuits are liable to be unstable and various kinds of oscillations induced. This paper deals with chaotic oscillations occurring in a direct-acting poppet valve circuit with a long pipeline on the basis of a distributed parameter model with average pipeline friction. Then, the influence of pipeline friction on chaotic oscillations was examined taking the pipeline length as a control parameter by using the method of numerical simulation. Simulation results are qualitatively in better agreement with experimental results than the case of a frictionless pipeline model.
• Aerodynamic drag reduction by feedback control of flow field

  K. Nisugi; T. Hayase; A. Shirai

  Proc. The 6th Triennial International Symposium on Flow Control, Measurement and Flow #060  2000/08
• Numerical Analysis of Flow Around the Main Valve of Hydraulic Damper and Effect of Axial Flow Force on Stability of the Damper

  SATO Naoto; HAYASHI Satoru; HAYASE Toshiyuki; SHIRAI Aatsushi

  Journal of the Japan Hydraulics & Pneumatics Society 日本油空圧学会 31 (1) 22 - 29 1343-4616 2000/01 [Refereed]
  
• Chaotic oscillations in a direct-acting poppet valve circuit (Pipeline length as a control parameter)

  Weimin Wang; Satoru Hayashi; Toshiyuki Hayase; Atsushi Shirai

  Proc. 4th JHPS Iternational Symposium on Fluid Power Tokyo'99 597 - 602 1999/11 [Refereed]
  
• Numerical simulation of water hydraulic relief valve

  Takayuki Nakanishi; Satoru Hayashi; Toshiyuki Hayase; Atsushi Shirai; Masao Jotatsu; Hideki Kawamoto

  Proc. 4th JHPS Iternational Symposium on Fluid Power Tokyo'99 555 - 560 1999/11 [Refereed]
  
• Eigenvalue analysis of direct-acting poppet valve circuit

  Atsushi Shirai; Satoru Hayashi; Toshiyuki Hayase; Weimin Wang

  Proc. 4th JHPS Iternational Symposium on Fluid Power Tokyo'99 303 - 308 1999/11 [Refereed]
  
• Stability of a direct-acting poppet valve circuit with a long pipeline

  Satoru Hayashi; Weimin Wang; Toshiyuki Hayase; Atsushi Shirai

  Proc. The 3rd International Symposium on Fluid Power Transmission and Control (ISFP'99) 7 - 12 1999/09 [Refereed]
  
• Chaotic Oscillations in a Direct-Acting Poppet Valve Circuit (Case of a Long Pipeline)

  WANG Weimin; HAYASHI Satoru; HAYASE Toshiyuki; SHIRAI Atsushi

  Journal of the Japan Hydraulics & Pneumatics Society 日本油空圧学会 30 (5) 119 - 127 1343-4616 1999/08 [Refereed]
  
• Deformation of red blood cells in fine capillaries

  Atsushi Shirai; Satoru Hayashi; Toshiyuki Hayase; Satoyuki Kawano

  Proc. International Conference on New Frontiers in Biomechanical Engineering 399 - 402 1999/07
• Eigenvalue Analysis of Direct-Acting Poppet Valve Circuit

  SHIRAI Atsushi; HAYASHI Satoru; HAYASE Toshiyuki; WANG Weimin

  Journal of the Japan Hydraulics & Pneumatics Society 日本油空圧学会 30 (3) 75 - 80 1343-4616 1999/05 [Refereed]
  
• Local Stability of a Direct-Acting Poppet Valve Circuit with a Long Pipeline

  WANG Weimin; HAYASHI Satoru; HAYASE Toshiyuki; SHIRAI Atsushi

  Proceedings of the JFPS International Symposium on Fluid Power The Japan Fluid Power System Society 30 (3) 67 - 74 1343-4616 1999/05 [Refereed]
   

  This paper deals with chaotic oscillations occurring in a direct-acting poppet valve circuit with a long pipeline. The system is liable to be unstable and various kinds of oscillations are induced. In this study, a distributed parameter model with average friction was derived for the system. Then, several complicated oscillations were examined taking the pipeline length as a control parameter by using the method of numerical simulation. It is shown that chaotic oscillations can occur in some ranges of the control parameter in this system.
• Numerical Analysis of Flow Pattern and Mass Transfer Around an Axisymmetric Red Blood Cell Moving in a Fine Capillary

  SHIRAI Atsushi; KAWANO Satoyuki; HASHIMOTO Hiroyuki; NITTA Shinichi

  Japanese journal of medical electronics and biological engineering 日本エム・イー学会 34 (2) 151 - 160 0021-3292 1996/06 [Refereed]
  
• Computer aided flow visualization and animation of three-dimensional solid-liquid two-phase jet at low Reynolds numbers

  H. Hashimoto; S. Kawano; A. Shirai; A. Ihara; T. Yamamoto

  Proc. 2nd International Conference on Multiphase Flow '95-Kyoto 4 AV9 - AV16 1995/04
• Computer aided flow visualization and animation of three-dimensional solid-liquid two-phase jet at low Reynolds numbers

  H Hashimoto; S Kawano; A Shirai; A Ihara; T Yamamoto

  Advances in Multiphase Flow ELSEVIER SCIENCE PUBL B V 383 - 393 1995 [Refereed]
  
• Applicability of lubrication theory to blood cells motion in fine capillaries

  Hiroyuki Hashimoto; Satoyuki Kawano; Atsushi Shirai; Akio Ihara

  Proc. The 3rd JSME-KSME Fluids Engineering Conference 166 - 170 1994/07

Conference Activities & Talks

• Development of VFG-Type Left Ventricular Assist Device (Measurement of pressure-flow rate characteristics)  [Not invited]

  笠松諒; 畑本宗一郎; 白井敦

  日本機械学会第33回バイオフロンティア講演会  2022/12
• 幻肢痛低減や運動機能回復への適用を目指したWebカメラを用いる安価な改良型鏡療法  [Invited]

  白井敦

  2021年度第1回ヘルスケア・医療福祉事業化交流会  2021/07
• Development of VFP-Type Left Ventricular Assist device (Production of tricuspid check valve and examination of pumping effect)  [Not invited]

  Hiroshi Miura; Atsushi Shirai

  日本機械学会第31回バイオフロンティア講演会  2020/12
• Development of a Mirror Visual Feedback System using a WEB Camera -Examination of extraction of images of a healthy limb-  [Not invited]

  Atsushi Shirai

  第29回計測自動制御学会中国支部学術講演会  2020/11
• 好中球ローリングのモデル実験  [Invited]

  白井敦

  近畿大学工学部研究公開フォーラム2019  2019/10
• Fundamental evaluation of a pulse wave measurement system mimicking pulse diagnosis using a wrist pulsatile blood flow model

  Tatsuya Tsuboi; Atsushi Shirai; Suguru Miyauchi; Toshiyuki Hayase

  15th International Conference on Flow Dynamics (ICFD2018)  2018/11
• Elucidation of mechanism of Fiber Bragg Grating vital sensing by Ultrasonic-Measurement-Integrated simulation: Flow analysis in ultrasound flow phantom

  Suguru Miyauchi; Toshiyuki hayase; Kosuke Inoue; Toshiyuki Ogasawara; Tatsuya Tsuboi; Atsushi Shirai; Shun Chino; Shouhei Koyama; Hiroaki Ishizawa

  15th International Conference on Flow Dynamics (ICFD2018)  2018/11
• Modeling of alveolar microcirculation for passage of neutrophils  [Invited]

  Atsushi Shirai

  15th international Conference on Flow Dynamics (ICFD2018)  2018/11
• Fundamental evaluation of a pulse wave measurement system using a wrist pulsatile flow model:Analysis of measured signal, blood pressure and vessel deformation  [Not invited]

  TSUBOI Tatsuya; SHIRAI Atsushi; MIYAUCHI Suguru; HAYASE Toshiyuki

  The Proceedings of the JSME Conference on Frontiers in Bioengineering  2018/10  The Japan Society of Mechanical Engineers
  
• Elucidation of Mechanisms of FBG vital sensing by Ultrasonic-Measurement-Integrated simulation::Experiment using Ultrasound Flow Phantom  [Not invited]

  HARADA Daisuke; MIYAUCHI Suguru; HAYASE Toshiyuki; INOUE Kosuke; SHIRAI Atsushi; KOYAMA Shouhei; ISHIZAWA Hiroaki

  日本機械学会東北支部第53期総会・講演会  2018/03  The Japan Society of Mechanical Engineers
  
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelial topography: Influence of pressing force on cell trajectories

  Atsushi Shirai; Jean-Paul Rieu

  ELyT Workshop 2018  2018/03
• A methodology to generate a randomly oriented capillary network on alveolus

  Atsushi Shirai; Kentaro Yamada

  15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE2018)  2018/03
• 手首拍動流モデルを用いた脈波計測システムの評価（計測波形と血管変形の関係）

  坪井達哉; 白井敦

  日本機械学会第30回バイオエンジニアリング講演会  2017/12
• 血管内皮表面を模擬したPDMS基板上におけるHL-60細胞の挙動解析（P-セレクチンの塗布による影響）

  荒井俊貴; 白井敦; Jean-Paul Rieu

  日本機械学会第30回バイオエンジニアリング講演会  2017/12
• Rolling experiment of HL-60 cells on patterned PDMS substrate coated by P-selectin

  Toshiki Arai; Atsushi Shirai; Jean-Paul Rieu

  14th International Conference on Flow Dynamics (ICFD2017)  2017/11
• Fundamental measurement of pulsation on a wrist pulsatile blood flow model using a pulse wave measurement system mimicking pulse diagnosis

  Tatsuya Tsuboi; Atsushi Shirai

  14th International Conference on Flow Dynamics (ICFD2017)  2017/11
• 凹凸を有するPDMS基板へのP-selectinおよびBSAのコーティングのための基礎的検討

  荒井俊貴; 白井敦; Jean-Paul Rieu

  日本機械学会第29回バイオエンジニアリング講演会  2017/01
• Fundamental study on generation of a 3-D alveolar capillary network model based on the bubble mesh method  [Not invited]

  Kentaro Yamada; Atsushi Shirai

  The 16th International conference on biomedical engineering (ICBME2016)  2016/12  JAPAN
• Influence of pressing force on rolling characteristics of HL-60 cell line on a bumpy substrate mimicking the endothelium topography  [Not invited]

  Atsushi Shirai; Jean-Paul Rieu; Ryota Sugimoto; Daisuke Yoshino

  The 16th International conference on biomedical engineering (ICBME2016)  2016/12  Singapore
• Hemodynamic model of acupuncture therapy  [Invited]

  Atsushi Shirai

  3rd Biomedical Symposium  2016/11  JAPAN
• Correlative effect of normal force and P-selectin concentration on rolling behavior of neutrophils  [Not invited]

  Ryota Sugimoto; Atsushi Shirai; Daisuke Yoshino; Jean-Paul Rieu

  13th International Conference on Flow Dynamics (ICFD2016)  2016/10  JAPAN
• Development of 2-D pulmonary capillary network model based on the bubble mesh method: Effects of segmentation and treatment of border capillaries on capillary length  [Not invited]

  Kentaro Yamada; Atsushi Shirai

  13th International Conference on Flow Dynamics (ICFD2016)  2016/10  JAPAN
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelial topography: PTV analysis of the cells motion on regular hexagonal pattern  [Not invited]

  Atsushi Shirai; Jean-Paul Rieu; Ryota Sugimoto; Daisuke Yoshino

  13th International Conference on Flow Dynamics (ICFD2016)  2016/10  JAPAN
• 血管内皮表面を模擬したPDMS基板上におけるHL-60細胞の挙動解析  [Not invited]

  白井敦; Jean-Paul Rieu; 杉本涼太; 吉野大輔

  日本流体力学会年会2016  2016/09  JAPAN
• Numerical simulation of propulsion mechanism of small aquatic creatures by ciliated swimming legs (Influence of clearance between cilia of single leg on propulsion force)  [Not invited]

  SHIRAI Atsushi; INOUE Kosuke; HAYASE Toshiyuki; SUDO Seiichi

  Transactions of the JSME (in Japanese)  2016/08  The Japan Society of Mechanical Engineers
   

  The goal of this study is elucidation of propulsion mechanism of small creatures by ciliated swimming legs. For this purpose, a ciliated pereiopod of an opossum shrimp was introduced and it was modeled with a straight cylindrical stem with 10 much narrower cylindrical poles perpendicularly projecting on the stem. Flow drag acting on the pereiopod in a steady flow, which corresponds to the thrust force by paddling of the pereiopod, was computed with a variety of clearance between each adjacent pair of cilia d and the flow velocity U. It was found that the drag increased with the increase in d to be saturated with a certain value in the range of d ≥ 0.04 mm where influence of boundary layers of adjacent cilia is negligible, and the drag agreed well with that estimated from drag of a two-dimensional cylinder. This result suggests that the opossum shrimp is propelled with the drag-based swimming and the ciliated pereiopods supply greater thrust force than tabular pereiopods with the same projection area. It was also found that the drag decreased in the range of d > 0.07 mm in which some cilia come into the boundary layer of body of the shrimp. It was optically observed that distance between adjacent cilia is around 0.07 mm on the stem and cilia near the root of the pereiopod are shorter than those near the tip. The present results suggest that the ciliated pereiopod is well designed to efficiently generate the thrust force within a limited length and mass by preventing influence of the boundary layers.

• バブルメッシュ法を用いた肺毛細血管網モデル構築に関する基礎的検討(節点サイズが毛細血管長に与える影響)  [Not invited]

  山田健太郎; 白井敦

  日本機械学会第28回バイオエンジニアリング講演会  2016/01  JAPAN
• 太衝(LR-3)への鍼刺激による血行動態変化の数学的再現(血行動態に対する両腕の末梢血管抵抗変化の寄与について)  [Not invited]

  鈴木琢也; 白井敦; 関隆志

  日本機械学会第28回バイオエンジニアリング講演会  2016/01  JAPAN
• Fundamental study of interaction between erythrocyte and endothelial cell under inclined centrifugal force: Physical explanation of interaction model

  Akira Yatsuyanagi; Toshiyuki Hayase; Suguru Miyauchi; Kenichi Funamoto; Kosuke Inoue; Atsushi Shirai; Luca Brandt

  12th International Conference on Flow Dynamics (ICFD2015)  2015/10
• Numerical reproduction of hemodynamic change induced by acupuncture needle stimulation to Taichong (LR-3): Modification of boundary conditions for quantitative agreement with experimental data

  Takuya Suzuki; Atsushi Shirai; Toshiyuki Hayase

  12th International Conference on Flow Dynamics (ICFD2015)  2015/10
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelial topography

  Atsushi Shirai; Jean-Paul Rieu

  The 15th International Symposium on Advanced Fluid Information (AFI-2015) in ICFD2015  2015/10
• 押しつけ力作用下における好中球のローリング特性解析・伝統中国医学の科学的検証  [Invited]

  白井敦

  東北大学・信州大学共催シンポジウム  2015/10
• Numerical Reproduction of Hemodynamic Change Induced by Acupuncture to ST-36

  Takuya Suzuki; Atsushi Shirai; Takashi Seki

  17th International Conference on Biological Engineering and Bionatural Sciences (ICBEBS 2015)  2015/09
• 傾斜遠心力場における血球の挙動解析  [Invited]

  白井敦

  日本機械学会2015年度年次大会  2015/09
• クロウリハムシの離陸飛行に関する研究

  山本翔也; 須藤誠一; 白井敦; 早瀬敏幸

  日本機械学会東北支部第50期総会・講演会  2015/03
• Rolling characteristics of neutrophils on PDMS surface mimicking the endothelium topography  [Not invited]

  Jean-Paul Rieu; Atsushi Shirai

  2015 Annual ELyT Workshop  2015/02  JAPAN
• 傾斜遠心力作用下における好中球様細胞の挙動解析  [Invited]

  白井敦

  日本機械学会P-SCC12（高度物理刺激と生体応答に関する研究分科会)第8回分科会  2015/01  JAPAN
• 傾斜遠心力場による赤血球と内皮細胞との力学的相互作用の解明(相互作用モデルの物理的解釈)

  八柳暁; 早瀬敏幸; 船本健一; 井上浩介; 白井敦

  日本機械学会第27回バイオエンジニアリング講演会  2015/01
• 傾斜遠心顕微鏡による内皮細胞上の赤血球の摩擦特性の計測(傾斜遠心力の垂直成分の影響)

  井上浩介; 早瀬敏幸; 船本健一; 白井敦

  日本機械学会第27回バイオエンジニアリング講演会  2015/01
• 超音波計測と計測融合シミュレーションによる血圧場と血流場の同時解析システム

  曾根周作; 早瀬敏幸; 船本健一; 白井敦

  日本機械学会第27回バイオエンジニアリング講演会  2015/01
• 押しつけ力がP-selectin上でのHL-60の移動特性に与える影響  [Not invited]

  杉本涼太; 白井敦; Jean-Paul Rieu; 吉野大輔

  日本機械学会第27回バイオエンジニアリング講演会  2015/01  JAPAN
• 鍼治療における血行動態の数学モデル構築 -太衝への刺鍼による血行動態変化の再現-  [Not invited]

  鈴木琢也; 白井敦; 関隆志

  日本機械学会第27回バイオエンジニアリング講演会  2015/01  JAPAN
• The jump of water springtail and morphology of the jumping organ

  Seiichi Sudo; Toshiya Kainuma; Tetsuya Yano; Atsushi Shirai; Toshiyuki Hayase

  9th International Symposium on Advanced Science and Technology in Experimental Mechanics (9th ISEM'14)  2014/11
• On the Motility and Locomotive Organs of Beach Flea  [Not invited]

  Seiichi Sudo; Takuya Amano; Atsushi Shirai; Toshiyuki Hayase

  The Sixth International Symposium on Aero Aqua Bio-Mechanisms (ISABME2014)  2014/11  United States
• Quantitative measurement of pulse waves using PVDF film sensor and cuff

  Yuta Wakabayashi; Atsushi Shirai

  11th International Conference on Flow Dynamics (ICFD2014)  2014/10
• Fundamental study of interaction between erythrocyte and endothelial cell under inclined centrifugal force (Reproduction of friction characteristics by numerical analysis using simple interaction model)

  Akira Yatsuyanagi; Toshiyuki Hayase; Kenichi Funamoto; Kosuke Inoue; Atsushi Shirai

  11th International Conference on Flow Dynamics (ICFD2014)  2014/10
• An aspect in flight morphology of the butterfly

  Seiichi Sudo; Ryosuke Tanaka; Kosuke Inoue; Atsushi Shirai; Toshiyuki Hayase

  11th International Conference on Flow Dynamics (ICFD2014)  2014/10
• 光電容積脈波計測と超音波計測融合シミュレーションによる頸動脈内の血圧と血流場の同時解析

  曾根周作; 早瀬敏幸; 船本健一; 白井敦

  日本流体力学会年会2014  2014/09
• 固体平板と水面でのトビムシの跳躍挙動における比較  [Not invited]

  須藤誠一; 貝沼俊哉; 矢野哲也; 白井敦; 井上浩介; 早瀬敏幸

  日本流体力学会年会2014  2014/09  JAPAN
• Simultaneous analysis system for blood pressure and flow using ultrasonic-measurement-integrated simulation

  Shusaku Sone; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  7th World Congress of Biomechanics (WCB2014)  2014/07
• 超音波計測融合シミュレーションにおける血流量推定精度の向上

  曾根周作; 早瀬敏幸; 船本健一; 白井敦

  日本超音波医学会第87回学術集会  2014/05
• 傾斜遠心力場における赤血球と内皮細胞との力学的相互作用の解明 (赤血球とグリコカリックスの相互作用モデルを用いた数値解析による摩擦特性の再現)

  八柳暁; 早瀬敏幸; 井上浩介; 船本健一; 白井敦

  日本機械学会東北支部第49期総会・講演会  2014/03
• 脈診における脈波同時計測システムの開発 ―カフを用いたPVDFフィルムセンサによる脈波計測の定量化―  [Not invited]

  若林勇太; 白井敦

  日本機械学会東北支部第49期総会・講演会  2014/03  JAPAN
• 傾斜遠心顕微鏡を用いた血球と固体壁との力学的相互作用の計測  [Invited]

  白井敦

  第98回岡山県医用工学研究会  2014/02  JAPAN
• Fundamental characteristics of motion of neutrophil-lik HL-60 cells on glass plate  [Not invited]

  Atsushi Shirai; Yoshiro Sugiyama

  2014 Annual ELyT Workshop  2014/02  France
• 光電脈波計測と超音波計測融合シミュレーションによる血圧と血流の同時計測システムの開発(開発システムによるWave Intensityの評価)

  曾根周作; 早瀬敏幸; 船本健一; 白井敦

  日本機械学会第26回バイオエンジニアリング講演会  2014/01
• HL-60の分化がガラス基板への付着性に与える影響  [Not invited]

  杉山佳郞; 白井敦

  日本機械学会第26回バイオエンジニアリング講演会  2014/01  JAPAN
• Influence of differentiation of HL-60 cells on their motion on a flat glass plate  [Not invited]

  Yoshiro Sugiyama; Atsushi Shirai

  The 15th International Conference on Biomedical Engineering. (ICBME2013)  2013/12  Singapore
• 微小血管における好中球の挙動  [Invited]

  白井敦

  日本機械学会2013年度年次大会  2013/09  JAPAN
• Simultaneous Analysis System for Blood Pressure and Flow Using Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation

  Shusaku Sone; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'13)  2013/07
• Friction characteristics of erythrocytes on endothelial-cultured or material-coated glass plates subject to inclined centrifugal forces

  Toshiyuki Hayase; Kosuke Inoue; Kenichi Funamoto; Atsushi Shirai

  8th International Conference on Multiphase Flow (ICMF2013)  2013/05
• 血液のながれ

  白井敦

  平成25年度みやぎ県民大学 東北大学流体科学研究所開放講座～流れを科学する～  2013
• ガラス平板上におけるHL60の挙動に与える分化の影響に関する傾斜遠心顕微鏡を用いた実験的研究  [Not invited]

  杉山佳郞; 白井敦; 早瀬敏幸

  日本機械学会第25回バイオエンジニアリング講演会  2013/01  JAPAN
• Numerical analysis of leviation mechanism of red blood cell in inclined centrifuge microscope - Effect of asymmetric cell shape on the motion

  Takashi Oshibe; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  Ninth International Conference on Flow Dynamics (ICFD2012)  2012/09
• 水上跳躍昆虫の流体力学的研究

  貝沼俊哉; 須藤誠一; 白井敦; 早瀬敏幸

  日本機械学会第2012年度年次大会  2012/09
• 分岐を考慮した腕部血管系一次元数学モデルにおける脈波の反射の検証  [Not invited]

  高島稔; 白井敦; 早瀬敏幸

  日本機械学会2012年度年次大会  2012/09  JAPAN
• 水棲微小生物の推進機構に関する数値解析（定常層流下における単一遊泳脚モデルの形状が推進力に与える影響）  [Not invited]

  井上浩介; 白井敦; 早瀬敏幸; 須藤誠一

  日本機械学会2012年度年次大会  2012/09  JAPAN
• 植物流体力学としての花弁表面細胞の研究  [Not invited]

  須藤誠一; 塩野正裕; 白井敦; 早瀬敏幸

  日本機械学会2012年度年次大会  2012/09  JAPAN
• The Jump of the Globular Springtail and Jumping Mechanism Worked by a Spring  [Not invited]

  Seiichi Sudo; Masahiro Shiono; Atsushi Shirai; Toshiyuki Hayase

  The 5th International Symposium on Aero Aqua Bio-mechanisms  2012/08  Taiwan
• Influence of Pressing Force on Motion of HL60 Cells on HUVEC substrate  [Not invited]

  Atsushi Shirai; Haruka Uranuma; Toshiyuki Hayase

  18th Congress of the European Society of Biomechanics (ESB2012)  2012/07  Portugal
• Dynamics in Motion of Dandelion Flower Head  [Not invited]

  Seiichi Sudo; Masahiro Shiono; Atsushi Shirai; Toshiyuki Hayase

  15th International Conference on Experimental Mechanics (ICEM15)  2012/07  Portugal
• Motion of fMLP-Stimulated HL60 Cells on HUVEC Cultured on a Flat Glass Plate  [Not invited]

  A. Shirai; H. Sato; T. Hayase

  26th International Conference on Surface Modification Technologies (SMT26)  2012/06  France
• Behavior of HL60 cells on HUVEC substrate under inclined centrifugal forces  [Not invited]

  Atsushi Shirai; Haruka Uranuma; Toshiyuki Hayase

  2012 Annual ELyT Workshop  2012/03  France
• トビムシの水面上での跳躍  [Not invited]

  貝沼俊哉; 須藤誠一; 白井敦; 早瀬敏幸

  日本機械学会東北支部第47期総会・講演会  2012/03  JAPAN
• ハマトビムシのロコモーション・メカニズム  [Not invited]

  天野拓也; 須藤誠一; 白井敦; 早瀬敏幸

  日本機械学会東北支部第47期総会・講演会  2012/03  JAPAN
• Observation of motion of HL60 cells on HUVEC using the inclined centrifuge microscope  [Invited]

  Atsushi Shirai

  Japan-China Joint Workshop on Bio, Material and Flow Dynamics  2012/02
• 傾斜遠心顕微鏡下での赤血球の浮上機構に関する数値解析 第2報：剛体赤血球モデルによる摩擦特性の再現性の検討  [Not invited]

  押部峻; 早瀬敏幸; 船本健一; 白井敦

  日本機械学会第24回バイオエンジニアリング講演会  2012/01  JAPAN
• ガラス平板上におけるHL60の挙動に与えるfMLP刺激の影響に関する傾斜遠心顕微鏡を用いた実験的研究  [Not invited]

  佐藤博紀; 白井敦; 早瀬敏幸

  日本機械学会第24回バイオエンジニアリング講演会  2012/01  JAPAN
• HUVEC基板上を移動するHL60に対する押しつけ力の影響  [Not invited]

  白井敦; 浦沼晴香; 早瀬敏幸

  日本機械学会第24回バイオエンジニアリング講演会  2012/01  JAPAN
• Numerical analysis for the effect of angle of attack on a red blood cell moving in an inclined centrifuge microscope

  Takashi Oshibe; Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai

  5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering  2011/12
• Contribution of Ulnar Artery to Numerical Reproduction of Indentation Experiment of Radial Artery for Scientific Verification of Pulse Diagnosis  [Not invited]

  Minoru Takashima; Atsushi Shirai; Toshiyuki Hayase

  5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering  2011/12  Singapore
• Movement of Springtail in Air  [Not invited]

  M. Shiono; S. Sudo; A. Shirai; T. Hayase

  Eighth International Conference on Flow Dynamics  2011/11  JAPAN
• Observation of Fly Wings and Flight Behavior  [Not invited]

  Kohei Kitadera; Seiichi Sudo; Atsushi Shirai; Toshiyuki Hayase

  Eighth International Conference on Flow Dynamics  2011/11  JAPAN
• Springtail Jump on Water Surface  [Not invited]

  Toshiya Kainuma; Seiichi Sudo; Atsushi Shirai; Toshiyuki Hayase

  The Eleventh International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (ICFD2011)  2011/11  JAPAN
• 傾斜遠心顕微鏡下での赤血球浮上機構に関する数値解析

  押部峻; 早瀬敏幸; 船本健一; 白井敦

  日本機械学会第22回バイオフロンティア講演会  2011/10
• 脈診を模擬した脈波計測の数値実験における尺骨動脈の影響  [Not invited]

  高島稔; 白井敦; 早瀬敏幸

  日本機械学会第22回バイオフロンティア講演会  2011/10  JAPAN
• Observation of Motion of HL60 Cells on HUVEC Cultured on a Flat Glass Plate using the Inclined Centrifuge Microscope  [Not invited]

  Atsushi Shirai; Takashi Umimoto; Haruka Uranuma; Toshiyuki Hayase

  ELyT Annual Workshop in Sendai 2011  2011/02  JAPAN 仙台
• Observation of velocity of Antibody-modified HL60 cells on glass plates using the inclined centrifuge microscope  [Not invited]

  Hiroki Sato; Atsushi Shirai; Toshiyuki Hayase

  4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering  2010/12  Singapore シンガポール
• 血管内皮細胞の配向方向が好中球の挙動に与える影響に関する実験的研究  [Not invited]

  浦沼晴香; 白井敦; 早瀬敏幸

  日本機械学会第21回バイオフロンティア講演会  2010/11  JAPAN 金沢
• Experimental Study on Effect of Direction of Endothelial Cells' Orientation on Motion of HL60 Cells  [Not invited]

  H. Uranuma; A. Shirai; T. Hayase

  The 7th International Conference on Flow Dynamics (ICFD2010)  2010/11  JAPAN 仙台
• 傾斜遠心顕微鏡で撮影された連続画像のぶれ補正手法  [Not invited]

  白井敦; 早瀬敏幸

  日本流体力学会年会2010  2010/09  JAPAN 札幌
• 傾斜遠心顕微鏡を用いたガラス平板上におけるHL60の微視的挙動に関する基礎的研究  [Not invited]

  佐藤博紀; 白井敦; 早瀬敏幸

  日本機械学会2010年度年次大会  2010/09  JAPAN 名古屋
• A Stabilization Technique of Wobbly Images taken by the Inclined Centrifuge Microscope  [Not invited]

  A. Shirai; T. Hayase

  6th World Congress of Biomechanics (WCB2010)  2010/08  Singapore シンガポール
• An Alligning Technique of Successive Images Taken by the Inclined Centrifuge Microscope  [Not invited]

  Atsushi Shirai

  2010 Annual ELyT Workshop  2010/03  France Sevrier
• G0200-1-5 Fundamental observation of microscopic behavior of HL60 cells on glass plate using the inclined centrifuge microscope

  Sato Hiroki; Shirai Atsushi; Hayase Toshiyuki

  The proceedings of the JSME annual meeting  2010  The Japan Society of Mechanical Engineers
   

  The authors have investigated the adhesion and friction characteristics of the neutrophils on a flat glass plate using the inclined centrifuge microscope. In their studies, however, precise behavior of the neutrophils on the plate has not been observed. In this study, microbeads were attached on the HL60 cells, a model cell of neutrophils, via an antibody as marker particles to observe if the cells were rolling or sliding on the plate. Some cells were observed to roll on the glass plate and showed the stick-slip motion. Influence of stimulation of the HL60 cells by the antibody on their adhesivity to the plate was also investigated with respect to the adhesion ratio. It was shown that the adhesion ratio of the stimulated cells did not change with coating of the plate with the MPC polymer which prevents the cells adhesion, while that of the not-stimulated cells decreased drastically.
• 血管モデル活用し、経験に基づく東洋医学を科学的に解明

  白井敦

  仙台トラビス, Vol. 19 (2010 Spring), 特別付録「健康REPORT2010」  2010
• 血液のながれ

  白井敦

  平成22年度みやぎ県民大学 東北大学流体科学研究所開放講座～流れを科学する～  2010
• Experimental observation of behavior of neutrophil-like HL60 cells on oriented endothelial cells

  Haruka Uranuma; Atsushi Shirai; Toshiyuki Hayase

  3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering  2009/12
• 血管内皮細胞の配向が好中球の挙動に与える影響に関する実験的研究  [Not invited]

  浦沼晴香; 白井敦; 早瀬敏幸

  日本機械学会2009年度年次大会  2009/09  JAPAN 盛岡市
• 健康度のわかる血管情報の可視化  [Invited]

  白井敦

  第8回情報科学技術フォーラム  2009/09  JAPAN 仙台市
• J0203-3-2 Experimental Observation of influence of Orientation of Endothelial Cells on Motion of Neutrophils

  URANUMA Haruka; SHIRAI Atsushi; HAYASE Toshiyuki

  The proceedings of the JSME annual meeting  2009  The Japan Society of Mechanical Engineers
   

  Neutrophils tend to adhere and roll on the endothelial cells (ECs) in blood vessels. In the former research, we observed behavior of neutrophil-like HL60 cells on cultured ECs in terms of the adhesion, ratio and moving velocity using the inclined centrifuge microscope. However, ECs exposed to blood flow are said to be oriented to the flow direction. In this study, we observed the motion of HL60s on oriented and on not-oriented ECs to investigate the influence of the orientation on the behavior of HL60s. Consequently, we found that adhesion ratio of HL60s is lower and the mean velocity is higher on the oriented ECs than not-oriented cells.
• 傾斜遠心顕微鏡を用いた好中球の内皮細胞に対する摩擦特性の計測  [Not invited]

  海本隆志; 白井敦; 早瀬敏幸

  日本機械学会第21回バイオエンジニアリング講演会  2009/01  JAPAN
• 脈診の科学的検証のための一次元数学モデルを用いた脈波計測実験の再現  [Not invited]

  中西勉; 白井敦; 早瀬敏幸

  日本機械学会第21回バイオエンジニアリング講演会  2009/01  JAPAN
• Multi-Scale Bio-Fluid Researches in IFS  [Not invited]

  Atsushi Shirai

  ELyT Lab. Workshop and Signing Ceremony  2008/12  JAPAN
• Measurement of Friction Characteristics of Neutrophils on MPC Polymer with the Inclined Centrifuge Microscope  [Not invited]

  Takashi Umimoto; Atsushi Shirai; Toshiyuki Hayase

  GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering  2008/12  Singapore
• Reproduction of Pulse Waveform Measurement using One-dimensional Mathematical Model for Validation of Pulse Diagnosis  [Not invited]

  Tsutomu Nakanishi; Atsushi Shirai; Toshiyuki Hayase

  GPBE/NUS-Tohoku Graduate Student Conference in Bioengineering  2008/12  Singapore
• Flow and Friction Characteristics of Neutrophils  [Not invited]

  IFS, Tohoku Univ. – Tsinghua Univ. Joint Workshop  2008/10  China
• 血液のながれ  [Not invited]

  白井敦

  平成20年度みやぎ県民大学 東北大学流体科学研究所開放講座～流れを科学する～  2008/09  JAPAN
• 傾斜遠心顕微鏡を用いた好中球のMPCポリマーに対する摩擦特性の計測  [Not invited]

  海本隆志; 白井敦; 早瀬敏幸

  日本機械学会第19回バイオフロンティア講演会  2008/09  JAPAN
• 脈診の科学的検証のための腕部皮下組織の力学モデルの検討  [Not invited]

  中西勉; 鳴海賢太郎; 白井敦; 早瀬敏幸

  第11回日本代替・相補・伝統医療連合会議(JACT) 第7回日本統合医療学会(JIM)合同大会2007 in 松島  2007/12  JAPAN 松島
• 肺毛細血管網における好中球の停滞時間が濃度上昇に与える影響  [Not invited]

  白井敦; 早瀬敏幸

  (社)日本機械学会創立110周年記念2007年度年次大会  2007/09  JAPAN 吹田市
• Effect of Retention Time of Neutrophils in Alveolar Capillaries on Increase in Their Concentration in the Capillary Network  [Not invited]

  Atsushi SHIRAI; Toshiyuki HAYASE

  5th Joint ASME/JSME Fluids Engineering Conference (FEDSM2007)  2007/07  United States San Diego, CA
• Effect of Neutrophils Retention Time in Capillaries on Increase in Their Concentration in a Lattice Capillary Network Model  [Not invited]

  Atsushi SHIRAI; Toshiyuki HAYASE

  ASME 2007 Summer Bioengineering Conference  2007/07  United States Keystone, CO
• 脈診の数値モデル構築のための基礎的研究

  鳴海賢太郎; 中西勉; 劉磊; 白井敦; 早瀬敏幸; 太田信; 金野敏; 川田浩; 丸山満也; 仁田新一

  日本機械学会東北支部第42期総会・講演会  2007/03
• 血球流動観察システムを用いた微小流路における血球の流動速度計測

  朝比奈翔; 白井敦; 早瀬敏幸

  日本機械学会東北支部第42期総会・講演会  2007/03
• 1122 Effect of Retention Time of Neutrophils in Pulmonary Capillary Network on Increase in Their Concentration in the Network

  SHIRAI Atsushi; HAYASE Toshiyuki

  The proceedings of the JSME annual meeting  2007  The Japan Society of Mechanical Engineers
   

  Neutrophils can be retained in pulmonary capillaries causing higher concentration than in systemic circulation, and it is thought to be due to the cells' low deformability in passing through narrow capillaries. The authors numerically simulated flow of neutrophils through a simple capillary network model taking into consideration the cells deformability. However, in the simulation, the concentration ratio of the cells between those in the network and those injected into the network was less than a half of the experimentally obtained value. Other possible factors for the long retention time are friction or plasma leak between the cells and the endothelium of the capillaries. In this paper, these effects were simply modeled to introduce into the simulation and their contribution to the increase in the concentration was numerically investigated. Consequently, it was found that the concentration ratio has an upper limit, and it increases only in the case large amount of plasma leak.
• 脈診における脈波情報の取得に関する数学モデルの構築と実験による検証  [Not invited]

  鳴海賢太郎; 中西勉; 劉磊; 井上浩介; 白井敦; 早瀬敏幸; 太田信; 金野敏; 川田浩; 丸山満也; 白石泰之; 仁田新一

  日本機械学会第17回バイオフロンティア講演会  2006/11  JAPAN 上田市 

  発表：鳴海
• 微小流路における好中球の流動観察システムの改良（MPCコーティングによる血球の流路への付着防止）  [Not invited]

  朝比奈翔; 白井敦; 早瀬敏幸

  日本機械学会第17回バイオフロンティア講演会  2006/11  JAPAN 上田市 

  発表：朝比奈
• 好中球の物性が毛細血管網の通過時間に与える影響  [Not invited]

  白井敦; 早瀬敏幸

  第84期日本機械学会流体工学部門講演会  2006/10  JAPAN 川越市
• 矩形流路における好中球の流動に関する数値解析（流路断面形状が通過時間に与える影響）  [Not invited]

  白井敦; 増田直; 早瀬敏幸

  日本機械学会2006年度年次大会  2006/09  JAPAN 熊本市
• 肺毛細血管網における好中球の流動シミュレーション  [Invited]

  白井敦

  21世紀COEプログラム 平成18年度第4回医工共同開催講義  2006/09  JAPAN 仙台市
• Numerical simulation of 3-D deformation of a neutrophil in a rectangular microchannel  [Not invited]

  Atsushi SHIRAI; Sunao MASUDA; Toshiyuki HAYASE

  The 5th World Congress of Biomechanics (WCB 2006)  2006/07  Germany Munich
• 3-D numerical simulation of flow of a neutrophil for the retention time in a moderate constriction of a rectangular microchannel  [Not invited]

  Atsushi SHIRAI; Sunao MASUDA; Toshiyuki HAYASE

  ASME 2006 Summer Bioengineering Conference  2006/06  United States Florida
• 634 Numerical Simulation of Flow of a Neutrophil through a Rectangular Microchannel : Effect of Cross-section size of the Channel on the Transit Time

  SHIRAI Atsushi; MASUDA Sunao; HAYASE Toshiyuki

  The proceedings of the JSME annual meeting  2006  The Japan Society of Mechanical Engineers
   

  Transit characteristics of neutrophils through narrow capillaries is the fundamental knowledge for the understanding of the behavior of the cells in immune system in lungs. Authors have developed a simple mathematical model to predict the transit time of the cell through a capillary segment considering the cell as a visco-elastic sphere and the segment as an axisymmetric moderate constriction in a straight pipe. However, the real capillaries do not have the perfect circle cross section, and thus, the cell has to deform three dimensionally in passing through it. In this paper, the capillary is considered to be a moderate constriction in a rectangular channel, and flow of the cell through the constriction is numerically investigated in terms of the transit time for some combinations of the minimum width of the constriction and height of the channel. The transit time is compared with the axisymmetric model to show the effect of cross section of the channel on the transit time.
• Moderate Constriction Model for Neutrophils Flow in Pulmonary Capillaries  [Not invited]

  A. Shirai

  The 12th International Conference on Biomedical Engineering (ICBME 2005)  2005/12  Singapore Singapore 

  Held as the 7th International Symposium of Future Medical Engineering Based on Bio-nanotechnology In the 12 the International Conference on Biomedical Engineering (ICBME 2005).
• Moderate constriction model for neutrophils flow in pulmonary capillaries

  A. Shirai; R. Fujita; T. Hayase

  The 7th International Symposium of Future Medical Engineering based on Bio-nanotechnology  2005/12
• Numerical analysis of effect of cross-section of microchannel on transit characteristics of neutrophils

  Sunao Masuda; Atsushi Shirai; Toshiyuki Hayase

  The 5th International Symposium on Advanced Fluid Information(AFI-2005)  2005/12
• Numerical Simulation for Spatial Distribution of Neutrophils in a Capillary Network  [Not invited]

  Atsushi Shirai; Toshiyuki Hayase

  The 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)  2005/11  JAPAN 仙台市
• 毛細血管ネットワークにおける好中球濃度の上昇に関する数値解析  [Not invited]

  白井敦; 早瀬敏幸

  日本機械学会 第16回バイオフロンティア講演会  2005/11  JAPAN 草津市
• 肺の毛細血管網を対象とした好中球流動のシミュレーションモデル開発  [Invited]

  白井敦; 藤田亮; 早瀬敏幸

  日本生体医工学会 第106回バイオメカニクス研究会  2005/09  JAPAN 仙台
• 微小流路の断面形状が好中球の流動特性に与える影響の数値解析  [Not invited]

  増田直; 白井敦; 早瀬敏幸

  日本機械学会2005年度年次大会  2005/09  JAPAN 東京 

  発表：増田
• 毛細血管ネットワークにおける好中球の濃度分布に関する数値解析  [Not invited]

  白井敦; 早瀬敏幸

  日本流体力学会年会2005  2005/09  JAPAN 東京
• Three-Dimensional Numerical Analysis of Plasma Flow around a Neutrophil in a Microchannel  [Not invited]

  Atsushi Shirai; Sunao Masuda; Toshiyuki Hayase

  ASME 2005 Summer Bioengineering Conference  2005/06  United States Vail, CO
• Three-dimensional numerical analysis of plasma flow around a neutrophil in a microchannel

  Atsushi Shirai; Sunao Masuda; Toshiyuki Hayase

  Proc. ASME 2005 Summer Bioengineering Conference  2005/06
• Inclined centrifuge microscope for measuring fractional characteristics of red blood cells moving on glass plate in plasma

  Toshiyuki Hayase; Hidekatsu Sugiyama; Takayuki Yamagata; Kosuke Inoue; Atsushi Shirai; Motohiro Takeda

  ASME 2005 Summer Bioengineering Conference  2005/06
• Flow simulation of neutrophils in capillary network (Effect of capillary geometry on transit time of cells through network)  [Not invited]

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  The 3rd IASTED International Conference on Biomedical Engineering (BioMED 2005)  2005/02  Austria インスブルック
• 1265 Numerical Analysis of Effect of Cross-Sectional Configuration of Channel on Transit Characteristics of a Neutrophil

  MASUDA Sunao; SHIRAI Atsushi; HAYASE Toshiyuki

  The proceedings of the JSME annual meeting  2005  The Japan Society of Mechanical Engineers
   

  Neutrophils retain in pulmonary capillaries causing 40- to 80-fold higher concentration than in systemic large vessels even in normal lungs. The highly concentrated neutrophils are effectively recruited to inflammations for the host defense. Tube-flow model and Sheet-flow model are well known in the investigation of blood flow in pulmonary capillaries. Cross-sectional configuration of Tube-flow model is circle, but that of Sheet-flow model is rectangular. In the previous research, flow of neutrophil in an axisymmetric capillary model was investigated. In this research, three-dimensional deformation of a neutrophil and flow of plasma in a rectangular model are simulated to investigate effects of the difference in cross-sectional configuration. The neutrophil is largely deformed in the direction of X- and Y-axes. There are clearances between corners of the channel and the cell during the cell is in the channel, and pressure acting on the cell decreases due to plasma leak through the clearances.
• 211 Improvement of Flow Channels in Observation System for Blood Cells in a Micro-Channel

  MASUDA Sunao; SHIRAI Atsushi; HAYASE Toshiyuki

  Proceedings of the JSME Bioengineering Conference and Seminar  2005  The Japan Society of Mechanical Engineers
  
• 212 Flow Simulation of Neutrophils in Capillary Network : Effect of Capillary Geometry on Transit Time of Cells Passing Through Network

  SHIRAI Atsushi; FUJITA Ryo; HAYASE Toshiyuki

  Proceedings of the JSME Bioengineering Conference and Seminar  2005  The Japan Society of Mechanical Engineers
  
• 毛細血管ネットワークにおける好中球の流動シミュレーション（血管形状がネットワーク通過時間に与える影響）

  白井敦; 藤田亮; 早瀬敏幸

  日本機械学会第17回バイオエンジニアリング講演会  2005/01
• 微小流路における血球流動観察システムの流路の改良

  増田直; 白井敦; 早瀬敏幸

  日本機械学会第17回バイオエンジニアリング講演会  2005/01
• Effect of Cell Stiffness on Transit Through Pulmonary Capillary Network  [Not invited]

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Thr Fourth International symposium on Advanced Fluid Information and The First International Symposium on Transdisciplinary Fluid Integration  2004/11  JAPAN 宮城県仙台市
• 傾斜遠心顕微鏡による赤血球の摩擦特性計測における赤血球の回転の影響

  斎藤琴美; 早瀬敏幸; 白井敦

  日本機械学会2004年度年次大会  2004/09
• 微小流路における血球の流動特性観察システムの開発

  増田直; 白井敦; 早瀬敏幸

  日本機械学会2004年度年次大会  2004/09
• 毛細血管ネットワークにおける好中球の流動シミュレーション

  白井敦; 藤田亮; 早瀬敏幸

  日本機械学会2004年度年次大会  2004/09
• 超音波計測融合シミュレーションのフィードバック則に関する検討

  船本健一; 早瀬敏幸; 白井敦; 西條芳文; 山家智之

  日本流体力学会年会2004  2004/08
• 毛細血管ネットワークにおける好中球の流動シミュレーション

  白井敦; 藤田亮; 早瀬敏幸

  日本流体力学会年会2004  2004/08
• Microscopic Observation of Red Blood Cells Moving on Glass Plate Under Inclined Centrifugal Force

  SAITO Kotomi; HAYASE Toshiyuki; SHIRAI Atushi

  The proceedings of the JSME annual meeting  2004/06  The Japan Society of Mechanical Engineers
   

  Precise frictional characteristics of the red blood cells (RBCs) have not been understood. Hayase et al. developed the inclined centrifuge microscope, and the frictional characteristics of RBCs on a glass plate were measured at the first step. In that research, it was the subject of discussion whether the cells glide or roll on the glass plate since the resolution of the microscope was not sufficient to distinguish the cell motion. This report deals with improvement of the observation technique for cell motion. At first, the magnification of the inclined centrifuge microscope is increased by 5 times. The shape of RBCs under movement can be seen clearly and cells seem to glide on the glass plate. However, it is still difficult to exclude the possibility of cell rolling. So authors investigated microbeads as the indicator of cell motion. It revealed that ordinary microbeads are too small to observe, and they don't adhere to RBCs.
• Development of a Measurement System of Blood Cell Velocities in Microchannels

  Sunao Masuda; Atsushi Shirai; Toshiyuki Hayase

  The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)  2004/06
• Microscopic Observation of Red Blood cells Moving on Glass Plate under Inclined Centrifugal Force

  Kotomi Saito; Takayuki Yamagata; Toshiyuki Hayase; Atsushi Shirai; Kosuke Inoue; Motohiro Takeda

  The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)  2004/06
• Application of Ultrasonic-Measurement-Integrated Simulation to Blood Flow

  Kenichi Funamoto; Toshiyuki Hayase; Atsushi Shirai; Yoshifumi Saijo; Tomoyuki Yambe

  The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)  2004/06
• Flow Simulation of Neutrophils in Pulmonary Capillary Network

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  The 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)  2004/06
• 傾斜遠心顕微鏡による細胞の摩擦特性の計測

  早瀬敏幸; 斎藤琴美; 山懸貴幸; 武田元博; 白井敦; 井上浩介

  第1回東北大学バイオサイエンスシンポジウム  2004/05
• Measurement of Frictional Characteristics of Cells Using Inclined Centrifuge Microscope  [Not invited]

  HAYASE Toshiyuki; SAITO Kotomi; YAMAGATA Takayuki; INOUE Kosuke; SHIRAI Atsushi

  日本流体力学会年会講演論文集  2004/08  日本流体力学会
   

  In order to understand precise frictional characteristics of the red blood cells in blood capillaries, the inclined centrifuge microscope has been developed, and the frictional characteristics of blood cells on a glass plate were measured as the first step. In that research, it was the subject of discussion whether the cells glide or roll on the glass plate since the resolution of the microscope was not sufficient to distinguish the cell motion. This report deals with improvement of the observation technique for cell motion. The magnification of the inclined centrifuge microscope is increased by 5 times. The shape of red blood cells under movement can be seen clearly and cells seem to glide on the glass plate, although it is still difficult to exclude the possibility of cell rolling.
• Flow Simulation of Neutrophil in Micro Capillary Network

  SHIRAI Atsushi; FUJITA Ryo; HAYASE Toshiyuki

  The proceedings of the JSME annual meeting  2004  The Japan Society of Mechanical Engineers
   

  Neutrophils are known as the most popular cells in leukocytes. They retain in pulmonary capillaries even in normal lungs causing 40- to 80-fold higher concentration than in systemic large vessels. The highly concentrated neutrophils are recruited to inflammations for the host defense. Therefore, it is essential to know their flow characteristics in the pulmonary capillary bed for the understanding of the immune system in lungs. For that purpose, authors have investigated the flow of a neutrophil in single capillary segment, and developed a mathematical model to simulate the flow of neutrophils in a capillary network. In this research, effect of the cell stiffness on the distribution of transit time of the cells is investigated. The result shows that the median of the transit times is longer than the average value for all the three levels of cell stiffness.
• Development of Observation System for Blood Cells in Micro-Channel

  MASUDA Sunao; SHIRAI Atsushi; HAYASE Toshiyuki

  The proceedings of the JSME annual meeting  2004  The Japan Society of Mechanical Engineers
   

  Neutrophils retain in pulmonary capillaries causing 40- to 80-fold higher concentration than in systemic large vessels in normal lungs. The highly concentrated neutrophils are effectively recruited to inflammations for the host defense. Therefore, it is important to know the flow characteristics of neutrophils in pulmonary capillary bed for the understanding of the immune system in lungs. In previous studies, flow of a neutrophil through a narrow capillary was investigated numerically to develop a mathematical model. It is indispensable to evaluate the accuracy of the model. In this research, an observation system of flow of blood cells in microchannels is constructed, and the cell velocities are measured. Neutrophils don't pass through the channel under the pressure control. Erythrocytes pass through it under the flow rate control, and their velocities are measured to show that the velocity profile along their loci varies with the cell orientation entering the channel.
• 毛細血管を通過して変形した好中球の最大半径の変化

  白井敦; 藤田亮; 早瀬敏幸

  日本機械学会第16回バイオエンジニアリング講演会  2004/01
• 血流の超音波計測融合シミュレーションに関する研究 第2報：大動脈瘤内の血流の再現

  船本健一; 早瀬敏幸; 白井敦; 山家智之; 西條芳文

  日本機械学会第16回バイオエンジニアリング講演会  2004/01
• Numerical Analysis for Affect of Neutrophil Shape on Transit Through Capillaries  [Not invited]

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  Third International Symposium on Advanced Fluid Information (AFI-2003)  2003/11  United States ニューヨーク
• Transit Characteristics of a Deformed Neutrophil Through a Moderate Constriction  [Not invited]

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  2003 ASME International Mechanical Engineering Conference (IMECE 2003)  2003/11  United States ワシントンＤ．Ｃ．
• Reproduction of Real Blood Flow in Aorta with Ultra sonic-Measurement-Integrated Simulation

  Kenichi Funamoto; Toshiyuki Hayase; Atsushi Shirai; Tomoyuki Yambe; Yoshifumi Saijo

  3rd International Symposium on Advanced Fluid Information (AFI-2003)  2003/11
• 血球の超音波計測融合シミュレーションに関する研究 第1報：上流速度境界条件に起因する誤差の改善

  船本健一; 早瀬敏幸; 白井敦; 山家智之; 西條芳文

  日本機械学会第14回バイオフロンティア講演会  2003/09
• 画像処理による傾斜遠心顕微鏡を用いた赤血球摩擦特性計測精度の改善

  半澤徹; 早瀬敏幸; 白井敦; 濱谷剛

  日本機械学会第14回バイオフロンティア講演会  2003/09
• Numerical simulation of noninvasive blood pressure measurement by partially pressurized collapsible tube model

  Satoru Hayashi; Masaru Maruyama; Toshiyuki Hayase; Atsushi Shirai

  7th International Symposium on Fluid Control, Measurement and Visualization (FLUCOME 2003)  2003/08
• 流れ場のフィードバック制御による大型車両の抵抗低減

  岩船兼昌; 早瀬敏幸; 白井敦

  日本機会学会2003年度年次大会  2003/08
• Drag Reduction of Large-Size Vehicle by Feedback Flow Control

  IWAFUNE Kensuke; HAYASE Toshiyuki; SHIRAI Atsushi

  The proceedings of the JSME annual meeting  2003  The Japan Society of Mechanical Engineers
   

  Drag reduction of vehicles is an important problem concerned with energy saving and the environment protection. Especially in the commercial transportation field, it benefits significant saving in the fuel cost. Aerodynamic drag reduction has been conducted by designing body shape, but commercial vehicles have restrictions in it to keep the loading capacity. Therefore, other method for the drag reduction is desired. This report deals with the drag reduction of a large-size vehicle using feedback control. For the first step, effect of the location of control point on the drag reduction is investigated numerically.
• Evidence-based Simulation of Blood Flow with Feedback of Ultrasonic Measurement

  Toshiyuki Hayase; Kenichi Funamoto; Atsushi Shirai; Tomoyuki Yambe; Yoshifumi Saijo

  The 1st International Symposium on Future Medical Engineering based on Bio-nanotechnology  2003/01
• Transit time of a deformed neutrophil through a pulmonary capillary segment  [Invited]

  白井敦

  The First International workshop on Hierarchical Life Cycle Evaluation of Complex Systems and The sixth International Workshop on Intelligent Fluid and Materials Systems  2002/12  JAPAN 宮城県仙台市
• Numerical Realization of Flow by Integrating Computation and Measurement in Medical Applications

  Toshiyuki Hayase; Kenichi Funamoto; Keisuke Nisugi; Atsushi Shirai; Tomoyuki Yambe; Yoshifumi Saijo

  AFI-2002 Mini-Symposium on Advanced Fluid Information - Fusion of EFD and CFD  2002/12
• Flow and deformation of a neutrophil passing through a constriction in a fine capillary  [Not invited]

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  The 5th JSME-KSME Fluids Engineering Conference  2002/11  JAPAN 愛知県名古屋市
• FUNDAMENTAL CONSIDERATION ON NUMERICAL ANALYSIS OF UNSTEADY FLOW THROUGH SPOOL VALVE

  HAYASE Toshiyuki; XIA Yupeng; SHIRAI Atsushi; HAYASHI Satoru

  Proceedings of the JFPS International Symposium on Fluid Power  2002/11  The Japan Fluid Power System Society
   

  The present paper deals with the numerical analysis on unsteady flow through a spool valve. Especially the effect of the spatial and temporal grid resolutions on the computational results is investigated. For the valve model of a simple geometry, unsteady fow was calculated for the step change of the supply pressure. Variations of the fow rate and the fow force were obtained for several values of the grid resolution and the time step. Comparison of the results revealed the complex convergence process of the relevant flow analysis. The transient response corresponding to the flow rate change does not much depend on spatial grid resolution and the time step. After the transition, the fow force is strongly affected by the time step, and its convergence with the grid refinement is rather slow, while the fow rate is not sensitive to the time step and converges with a relatively rough spatial grid resolution.
• Fundamental consideration on numerical analysis of unsteady flow through spool valve

  Toshiyuki Hayase; Yupeng Xia; Atsushi Shirai; Satoru Hayashi

  The 5th JFPS International Symposium  2002/11
• 数値解析と実験計測を統合したハイブリッド風洞に関する基礎的研究(2次元での解析)

  仁杉圭延; 早瀬敏幸; 白井敦

  第45回自動制御連合講演会  2002/11
• 流れの数値解析を融合した超音波診断装置の基礎的研究

  船本健一; 早瀬敏幸; 白井敦

  第45回自動制御連合講演会  2002/11
• 実験計測と数値解析を融合したハイブリッド風洞に関する基礎的研究(リアルタイムでの解析に関する検討)

  仁杉圭延; 早瀬敏幸; 白井敦

  日本機械学会東北支部八戸地方講演会  2002/09
• 円弧状狭窄において好中球の無次元物性値がその通過時間に与える影響

  白井敦; Mark Bathe; 藤田亮; 早瀬敏幸

  日本機械学会第13回バイオエンジニアリング学術講演会・秋期セミナー  2002/09
• 数値解析と実験計測を融合したハイブリッド風洞における解析性能の大幅な向上について

  仁杉圭延; 白井敦; 早瀬敏幸

  日本機械学会2002年度年次大会  2002/09
• 傾斜遠心力下の赤血球の挙動に関する流動数値解析

  船本健一; 早瀬敏幸; 白井敦

  日本機械学会2002年度年次大会  2002/09
• Effect of constriction geometry on transit of deformed neutrophils in capillaries  [Not invited]

  Atsushi Shirai; Ryo Fujita; Toshiyuki Hayase

  4th World Congress of Biomechanics (WCB2002)  2002/08  Canada カルガリー
• Three-dimensional flow analysis in VFP type artificial heart by unstructured grid

  Satoyuki Kawano; Takuma Kato; Kazuhiro Nakahashi; Atsushi Shirai; Toshiyuki Hayase; Tomoyuki Yambe; Shin-ichi Nitta; Hiroyuki Hashimoto

  Computational technologies for fluid/thermal/structural/chemical systems with industrial applications  2002/08
• Numerical realization of flow field by integrating computation and measurement

  Toshiyuki Hayase; Keisuke Nisugi; Atsushi Shirai

  5th World Congress on Computational Mechanics (WCCM V)  2002/07
• 毛細血管狭窄部における変形した好中球の流動特性（狭窄部最小流路半径の影響）

  藤田亮; 白井敦; 早瀬敏幸

  日本流体力学会年会2002  2002/07
• 傾斜遠心顕微鏡による微小速度域における赤血球の摩擦特性の計測

  杉山英勝; 早瀬敏幸; 白井敦; 濱谷剛

  日本流体力学会年会2002  2002/07
• 微小血管における血漿流動と血球変形の連成問題  [Invited]

  白井敦

  日本機会学会計算力学部門「流体と構造の複合問題研究会・バイオエンジニアリング部門「制御と情報－生体への応用研究会」共同企画「Multidisciplinary Lecture Series 5」  2002/03  JAPAN 宮城県仙台市 

  日本機械学会 計算力学部門「流体と構造の複合問題研究会」・バイオエンジニアリング部門「制御と情報－生体への応用研究会」共同企画
• 直角分岐管内流れの数値解析（不安定振動の発生機構）

  内藤大貴; 早瀬敏幸; 白井敦; 山口隆平

  日本機械学会東北支部第37期総会・講演会  2002/03
• 実験計測と数値解析を統合したハイブリッド風洞に関する基礎的研究(フィードバック則の検討)

  武田晋平; 仁杉圭延; 白井敦; 早瀬敏幸

  日本機械学会東北支部第37期総会・講演会  2002/03
• 2つの狭窄部を持つ毛細血管内における好中球の流動特性

  白井敦; 藤田亮; 早瀬敏幸

  日本機械学会第14回バイオエンジニアリング講演会  2002/03
• Numerical Simulation of Red Blood Cell under Inclined Centrifugal Force

  FUNAMOTO Kenichi; HAYASE Toshiyuki; SHIRAI Atsushi

  The proceedings of the JSME annual meeting  2002  The Japan Society of Mechanical Engineers
   

  Two dimensional flow analysis was performed to simulate the former experiment using the inclined centrifuge microscope for the frictional characteristics of red blood cells moving on a glass plate in a medium. Lift, drag and momentum acting on a red blood cell were obtained in various conditions. Considering a balance among various forces acting on a red blood cell, the frictional characteristics of a red blood cell were modeled as the sum of Coulomb friction and drag. The result indicates the possibility that a red blood cell deforms to expand on the front side, and the plasma layer of the thickness of 0.16 μm exists on a glass plate.
• Significant Improvement of Analysis Performance in Hybrid Wind Tunnel With Integration of Numerical Simulation and Experimental Measurement

  NISUGI Keisuke; SHIRAI Atsushi; HAYASE Toshiyuki

  The proceedings of the JSME annual meeting  2002  The Japan Society of Mechanical Engineers
   

  The new flow field analysis system of "Hybrid Wind Tunnel" is proposed. The basic idea of this facility is an integration of experimental measurement and computer simulation for general flow related problems. The problem treated in this work is well-known flow field as Karman Vortex Street in a wake of a column. The fundamental system components and first-step results are investigated in previous report. In the report, favorable results have been earned even if it used a course grid system. It is generally known that very-fine grid spacing and time increment are necessary for high-accurate numerical analysis. So it needs a huge calculation load. In this paper, the hybrid wind tunnel is compared to the ordinary numerical analysis with fine grid spacing and time increments in its analysis performance including accuracy and calculation time. As a result, calculation load is drastically decreased with valid accuracy.
• Effect of Non-dimensional Mechanical Properties of a Neutrophil on the Transit Time Through a Moderate Constriction

  SHIRAI Atsushi; BATHE Mark; FUJITA Ryo; HAYASE Toshiyuki

  Proceedings of the JSME Bioengineering Conference and Seminar  2002  The Japan Society of Mechanical Engineers
  
• 実験計測と数値解析を統合したハイブリッド風洞に関する基礎的研究（リアルタイム処理に向けた計算速度と精度の検討）

  仁杉圭延; 白井敦; 早瀬敏幸

  計測自動制御学会東北支部第199回研究集会  2001/12
• 遠心顕微鏡による赤血球の摩擦特性の計測

  早瀬敏幸; 白井敦; 杉山英勝; 濱谷剛

  計測自動制御学会東北支部第198回研究集会  2001/11
• The Effect of Neutrophil Activation on Transit Time through Pulmonary Capillaries  [Not invited]

  Atsushi Shirai; Mark Bathe; Roger D. Kamm

  The First Internaional Symposium on Advanced Fluid Information (AFI-2001)  2001/10  JAPAN 宮城県仙台市
• Multi-Scale Simulation in biological Systems

  Roger Kamm; Eun-Bo Shim; Atsushi Shirai; Mark Bathe; Thomas Heldt; Hesham Younis; Ana Isasi; Mohammad Kaazempur-Mofrad; Wonmuk Hwang

  The 1st International Symposium on Advanced Fluid Information (AFI-2001)  2001/10
• 狭窄部を持つ毛細血管内における好中球の流動特性

  白井敦; 藤田亮; 早瀬敏幸

  日本機械学会第12回バイオエンジニアリング学術講演会・秋期セミナー  2001/10
• 遠心力の作用下でガラス板上を移動数赤血球の数学モデル

  早瀬敏幸; 杉山英勝; 白井敦; 濱谷剛

  日本機械学会第12回バイオエンジニアリング学術講演会・秋期セミナー  2001/10
• 傾斜遠心顕微鏡による赤血球の流動特性の測定

  早瀬敏幸; 杉山英勝; 白井敦; 濱谷剛

  日本機械学会流体工学部門講演会  2001/10
• 直角分岐管内流れの数値解析（不安定振動の空間分布）

  内藤大貴; 早瀬敏幸; 白井敦; 山口隆平

  日本機械学会流体工学部門講演会  2001/10
• 毛細血管狭窄部における好中球の変形挙動

  白井敦; 藤田亮; 早瀬敏幸

  日本機械学会流体工学部門講演会  2001/10
• 実験風洞と数値解析を統合したハイブリッド風洞に関する基礎的研究(推定性能の評価)

  武田晋平; 仁杉圭延; 白井敦; 早瀬敏幸

  日本機械学会流体工学部門講演会  2001/10
• 実験風洞と数値解析を融合したハイブリッド風洞に関する基礎的研究(フィードバック則の検討)

  仁杉圭延; 武田晋平; 白井敦; 早瀬敏幸

  日本機械学会流体工学部門講演会  2001/10
• Static and dynamic characteristics of a pressure-compensated flow control

  Satoru Hayashi; Atsushi Shirai; Nan-nan Guo; Toshiyuki Hayase

  The 5th International Conference on Fluid Power Transmission and Control (ICFP'2001)  2001/04
• 1B16 Flow of Neutrophils in Fine Capillaries with Constriction

  SHIRAI Atsushi; FUJITA Ryo; HAYASE Toshiyuki

  Proceedings of the JSME Bioengineering Conference and Seminar  2001  The Japan Society of Mechanical Engineers
  
• 1B13 Mathematical Model of Red Blood Cell Moving on Glass Plate under the Influence of Centrifugal Force

  HAYASE Toshiyuki; SUGIYAMA Hidekatsu; SHIRAI Atsushi; HAMAYA Tsuyoshi

  Proceedings of the JSME Bioengineering Conference and Seminar  2001  The Japan Society of Mechanical Engineers
  
• 直角分岐管内流れの数値解析（シャープエッジの分岐管全体の解析）

  内藤大貴; 早瀬敏幸; 白井敦; 山口隆平

  日本機械学会第13回バイオエンジニアリング講演会  2001/01
• 赤血球の摩擦特性の計測（抗力の影響）

  坂下重人; 白井敦; 濱谷剛; 早瀬敏幸

  日本機械学会第13回バイオエンジニアリング講演会  2001/01
• 角柱周りの流れ場のオブザーバに関する実験

  武田晋平; 仁杉圭延; 白井敦; 早瀬敏幸

  計測自動制御学会東北支部第192回研究集会  2000/12
• 赤血球の摩擦特性の計測

  坂下重人; 早瀬敏幸; 白井敦; 濱谷剛

  日本機械学会第11回バイオエンジニアリング学術講演会・秋季セミナー  2000/10
• Aerodynamic drag reduction by feedback control of flow field

  K. Nisugi; T. Hayase; A. Shirai

  The 6th Triennial International Symposium on Flow Control, Measurement and Flow Visualization (FLUCOME2000)  2000/08
• 実験風洞と数値解析を統合したハイブリッド風洞に関する基礎的研究(カルマン渦列の解析)

  早瀬敏幸; 仁杉圭延; 白井敦

  日本機械学会2000年度年次大会  2000/08
• 車両周りの流れ場のフィードバック制御(制御パラメータの影響）

  仁杉圭延; 早瀬敏幸; 白井敦, 林叡

  日本機械学会2000年度年次大会  2000/08
• 直角分岐管内流れの数値解析(枝管部における周期的変動の発生機構)

  中川忠; 白井敦; 早瀬敏幸; 林叡; 山口隆平

  日本機械学会2000年度年次大会  2000/08
• Numerical Simulation of Flow in Right Angle Branch : Mechanism of Periodical Flow Oscillation in Side Branch

  NAKAGAWA Tadashi; SHIRAI Atsushi; HAYASE Toshiyuki; HAYASHI Satoru; YAMAGUCHI Ryuhei

  The proceedings of the JSME annual meeting  2000  The Japan Society of Mechanical Engineers
   

  This report deals with a numerical analysis on the stability of a flow in a right angle side branch. Spatial growth of velocity perturbation at the upstream boundary of the side branch is examined for various frequencies. The computational result revealed that frequency range of the maximum amplification coincides with that of the fluctuation observed in experiment. Distribution of the wall shear stress fluctuation due to instability shows the local extremum in both the proximal and the distal wall.
• Fundamental Study on Hybrid Wind Tunnel : Analysis of Karman Vortex Street

  HAYASE Toshiyuki; NISUGI Keisuke; SHIRAI Atsushi

  The proceedings of the JSME annual meeting  2000  The Japan Society of Mechanical Engineers
   

  This report proposes a new concept of "Hybrid Wind Tunnel". The basic idea of this facility is an integration of experimental measurement and computer simulation for general flow related problems. A general structure of the equipment is first explained and a possible application for a simple unsteady flow problem is then discussed. The problem treated in this work is well-known flow field as Karman vortex street in a wake of a column. As the first step, a flow velocity component is estimated in off-line operation of the hybrid wind tunnel with feedback of the measurement pressure data on the column wall. Comparing the estimated data with measurement, the estimation performance of hybrid wind tunnel is investigated. As the results, even if its feedback scheme is tentative, it is shown that the estimated pressure and velocity is close to the measured one with its fluctuation and phase.
• Feedback Control of Flow Field around the Vehicle : Effect of Control Parameters

  NISUGI Keisuke; HAYASE Toshiyuki; SHIRAI Atsushi; HAYASHI Satoru

  The proceedings of the JSME annual meeting  2000  The Japan Society of Mechanical Engineers
   

  This report deals with the numerical simulation of flow field around the vehicle with feedback control. In previous work, the flow field and vortex structure around the vehicle was investigated and effect of control port location was surveyed. The control law was composed of control parameters, such as the monitoring point location of the flow velocity output, the bias velocity, and the feedback gain. In this report, the effect of drag reduction and lift is surveyed for these parameters. As the result, lift is increased whenever the drag is reduced drastically in some parameter region. But using a simple front spoiler for the numerical model as aerodynamical device, the drag reduction keeps its effect while suppression the lift increase.
• Measurement of Frictional Characteristics of a Red Blood Cell

  SAKASHITA Shigeto; HAYASE Toshiyuki; SHIRAI Atsushi; HAMAYA Tsuyoshi

  Proceedings of the JSME Bioengineering Conference and Seminar  2000  The Japan Society of Mechanical Engineers
  
• コラプシブルチューブの自励振動におけるチューブの軸方向初期ひずみの影響（数値シミュレーション）

  夏毓鵬; 早瀬敏幸; 林叡; 濱谷剛; 白井敦

  日本機械学会第12回バイオエンジニアリング講演会  2000/01
• 車両まわりの流れ場のフィードバック制御に関する数値解析

  仁杉圭延; 早瀬敏幸; 白井敦, 林叡

  第13回数値流体力学シンポジウム  1999/12
• 水圧用圧力補償型流量制御弁の流動特性解析

  白井敦; 林叡; 早瀬敏幸; 郭南楠

  計測自動制御学会東北支部第185回研究集会  1999/12
• 圧力補償型流量制御弁の数値シミュレーション

  白井敦; 林叡; 早瀬敏幸; 郭南楠

  第17回流体計測，第14回流体制御合同シンポジウム  1999/12
• Eigenvalue analysis of direct-acting poppet valve circuit  [Not invited]

  Atsushi Shirai; Satoru Hayashi; Toshiyuki Hayase; Weimin Wang

  The Forth JHPS International Symposium  1999/11  JAPAN 東京都有明
• Chaotic oscillations in a direct-acting poppet valve circuit (Pipeline length as a control parameter)

  Weimin Wang; Satoru Hayashi; Toshiyuki Hayase; Atsushi Shirai

  4th JHPS Iternational Symposium on Fluid Power Tokyo'99  1999/11
• Numerical simulation of water hydraulic relief valve

  Takayuki Nakanishi; Satoru Hayashi; Toshiyuki Hayase; Atsushi Shirai; Masao Jotatsu; Hideki Kawamoto

  4th JHPS Iternational Symposium on Fluid Power Tokyo'99  1999/11
• 直動型ポペット弁回路に発生するカオス振動(管路長をパラメーターとする場合)

  王偉民; 林叡; 早瀬敏幸; 白井敦

  平成11年春期フルイドパワーシステム講演会  1999/11
• スーパーコンピュータと実験計測を統合したハイブリッド風洞に関する基礎的研究（基本構造の検討）

  早瀬敏幸; 仁杉圭延; 牧野芳和; 白井敦, 林叡

  計測自動制御学会東北支部35周年記念学術講演会  1999/10
• 吹き出し制御による車両の空力抵抗低減

  仁杉圭延; 早瀬敏幸; 白井敦, 林叡

  平成11年秋期フルイドパワーシステムワークショップ  1999/10
• 直動型ポペット弁回路の固有値解析と非線形挙動

  白井敦; 王偉民; 林叡; 早瀬敏幸

  平成11年秋期フルイドパワーシステムワークショップ  1999/10
• Stability of a direct-acting poppet valve circuit with a long pipeline

  Satoru Hayashi; Weimin Wang; Toshiyuki Hayase; Atsushi Shirai

  The 3rd International Symposium on Fluid Power Transmission and Control (ISFP'99)  1999/09
• フィードバック制御による車両空力抵抗の低減に関する数値解析

  仁杉圭延; 早瀬敏幸; 白井敦, 林叡

  計測自動制御学会第38回学術講演会  1999/07
• 輸送機器まわりの流れ場のフィードバック制御による空力抵抗の低減

  仁杉圭延; 早瀬敏幸; 白井敦, 林叡

  計測自動制御学会東北支部第183回研究集会  1999/07
• 直動型ポペット弁回路の安定性について(アキュムレータによる制振効果に関する一考察)

  白井敦; 林叡; 早瀬敏幸; 王偉民

  平成11年春期フルイドパワーシステム講演会  1999/05
• 微小循環における赤血球の確率的な流れに関する数値解析(確率密度の影響)

  韮澤英夫; 早瀬敏幸; 林叡, 白井敦

  日本機械学会第11回バイオエンジニアリング講演会  1999/03
• 直動型ポペット弁回路の集中定数近似モデルについて

  白井敦; 林叡; 早瀬敏幸; 王偉民

  平成10年春期油空圧講演会  1998/10
• 直動型ポペット弁回路に発生するカオス振動（長い給油管路の場合）

  王偉民; 林叡; 早瀬敏幸; 白井敦

  計測自動制御学会第13回流体制御シンポジウム  1998/08
• Deformation of red blood cells in fine capillaries

  Atsushi Shirai; Satoru Hayashi; Toshiyuki Hayase; Satoyuki Kawano

  International Conference on New Frontiers in Biomechanical Engineering  1997/07
• 毛細血管内における赤血球の流動解析に適した曲線座標格子形成法

  白井敦; 川野聡恭; 林叡; 橋本弘之

  混相流シンポジウム'96（第15回）  1996/07
• 毛細血管内における赤血球周囲の流動特性

  白井敦; 川野聡恭; 橋本弘之; 林叡

  日本機械学会第73期通常総会講演会  1996/04
• 三次元固液混層噴流のコンピュータアニメーション

  白井敦; 川野聡恭; 橋本弘之; 庵原昭夫

  混相流シンポジウム'95（第14回）  1995/07
• Computer Aided Flow Visualization and Animation of Three-Dimensional Solid-Liquid Two-Phase Jet at Lowr Reynolds Numbers  [Not invited]

  H. Hashimoto; S. Kawano; A. Shirai; A. Ihara; T. Yamamoto

  The 2nd International Conference on Multiphase Flow '95-Kyoto  1995/04  JAPAN 京都府左京区
• 毛細血管内における赤血球の簡易流動モデル（曲線座標変換法による数値解析）

  白井敦; 川野聡恭; 橋本弘之; 庵原昭夫

  日本機械学会流体工学部門講演会  1994/11
• Applicability of lubrication theory to blood cells motion in fine capillaries  [Not invited]

  Hiroyuki Hashimoto; Satoyuki Kawano; Atsushi Shirai; Akio Ihara

  The Third JSME-KSME Fluids Engineering Conference  1994/07  JAPAN 宮城県仙台市
• 毛細血管内における赤血球の流動モデル（円筒モデルによる数値解析）

  白井敦; 川野聡恭; 橋本弘之

  日本機械学会第17期全国大会  1993/10

MISC

• 2E25 Development of pulmonary capillary network model based on the bubble mesh method : Effects of node size on capillary lengths

  YAMADA Kentaro; SHIRAI Atsushi  バイオエンジニアリング講演会講演論文集  2016-  (28)  "2E25  -1"-"2E25-5"  2016/01
• F051001 Observation of Motion of Blood Cells under Inclined Centrifugal Forces

  SHIRAI Atsushi  Mechanical Engineering Congress, Japan  2015-  "F051001  -1"-"F051001-5"  2015/09
• 1D43 Fundamental study of interaction between erythrocyte and endothelial cell under inclined centrifugal force : Physical explanation of interaction model

  YATSUYANAGI Akira; HAYASE Toshiyuki; FUNAMOTO Kenichi; INOUE Kosuke; SHIRAI Atsushi  バイオエンジニアリング講演会講演論文集  2015-  (27)  171  -172  2015/01
• 1D42 Measurement of frictional characteristics of erythrocytes on endothelial cells with an inclined centrifuge microscope : influence of normal component of inclined centrifugal force

  INOUE Kosuke; HAYASE Toshiyuki; FUNAMOTO Kenichi; SHIRAI Atsushi  バイオエンジニアリング講演会講演論文集  2015-  (27)  169  -170  2015/01
• 超音波計測と計測融合シミュレーションによる血圧場と血流場の同時解析システム

  曾根周作; 早瀬敏幸; 船本健一; 白井敦  バイオエンジニアリング講演会講演論文集  27th-  2015
• Observation of Rolling Characteristics of Neutrophils under Contact Forces : In vitro observation using the inclined centrifuge microscope

  白井 敦; 海本 隆志  可視化情報学会誌  34-  (134)  120  -125,図巻頭1p  2014/07  [Invited]
  
• 168 Fundamental Study of Interaction between Red Blood Cell and Endothelial Cell under Inclined Centrifugal Force : Reproduction of Friction Characteristics by Numerical Analysis Using Interaction Model

  YATSUYANAGI Akira; HAYASE Toshiyuki; INOUE Kosuke; FUNAMOTO Kenichi; SHIRAI Atsushi  講演論文集  2014-  (49)  133  -134  2014
• J024044 Verification of reflected pressure pulse waves at bifurcation of one-dimensional arterial vascular model of an arm

  TAKASHIMA Minoru; SHIRAI Atsushi; HAYASE Toshiyuki  Mechanical Engineering Congress, Japan  2012-  "J024044  -1"-"J024044-5"  2012/09
• J024021 Hydrodynamics of Water-jumping Insect

  KAINUMA Toshiya; SUDO Seiichi; SHIRAI Atsushi; HAYASE Toshiyuki  Mechanical Engineering Congress, Japan  2012-  "J024021  -1"-"J024021-4"  2012/09
• J024022 Numerical Simulation for Propulsion Mechanism of Small Aquatic Creatures : Influence of shape of single pleopod model on propulsion force in a steady laminar flow

  INOUE Kosuke; SHIRAI Atsushi; HAYASE Toshiyuki; SUDO Seiichi  Mechanical Engineering Congress, Japan  2012-  "J024022  -1"-"J024022-4"  2012/09
• S054031 A Study on the Petal Surface Cells as the Plant Hydrodynamics

  SUDO Seiichi; SHIONO Masahiro; SHIRAI Atsushi; HAYASE Toshiyuki  Mechanical Engineering Congress, Japan  2012-  "S054031  -1"-"S054031-4"  2012/09
• 106 Locomotion Mechanism of Beach Flea

  AMANO Takuya; SUDO Seiichi; SHIRAI Atsushi; HAYASE Toshiyuki  講演論文集  2012-  (47)  18  -19  2012/03
• 105 Jump of Springtail on the Water Surface

  KAINUMA Toshiya; SUDO Seiichi; SHIRAI Atsushi; HAYASE Toshiyuki  講演論文集  2012-  (47)  16  -17  2012/03
• 8F23 Observation of influence of fMLP stimulation on behavior of HL60 cells on glass plate using the inclined centrifuge microscope

  SATO Hiroki; SHIRAI Atsushi; HAYASE Toshiyuki  バイオエンジニアリング講演会講演論文集  2012-  (24)  "8F23  -1"-"8F23-2"  2012/01
• 8F21 Influence of normal force on behavior of HL60 cells moving on HUVEC substrate

  SHIRAI Atsushi; URANUMA Haruka; HAYASE Toshiyuki  バイオエンジニアリング講演会講演論文集  2012-  (24)  "8F21  -1"-"8F21-2"  2012/01
• 8F24 Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope : 2nd Report: Validity of Rigid Red Blood Cell Model for Reproduction of Friction Characteristics

  OSHIBE Takashi; HAYASE Toshiyuki; FUNAMOTO Kenichi; SHIRAI Atsushi  バイオエンジニアリング講演会講演論文集  2012-  (24)  "8F24  -1"-"8F24-2"  2012/01
• A207 Contribution of ulnar artery on numerical reproduction of pulse wave measurement in pulse diagnosis

  TAKASHIMA Minoru; SHIRAI Atsushi; HAYASE Toshiyuki  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2011-  (22)  91  -92  2011/10
• B120 Numerical Analysis of Levitation Mechanism of Red Blood Cell in Inclined Centrifuge Microscope

  OSHIBE Takashi; HAYASE Toshiyuki; FUNAMOTO Kenichi; SHIRAI Atsushi  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2011-  (22)  77  -78  2011/10
• A204 Experimental study on effect of direction of orientation of endothelial cells on motion of neutrophils

  URANUMA Haruka; SHIRAI Atsushi; HAYASE Toshiyuki  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2010-  (21)  45  -46  2010/11
• A Compensation Technique of Shaking of Successive Images Taken by the Inclined Centrifuge Microscope

  SHIRAI Atsushi; HAYASE Toshiyuki  日本流体力学会年会講演論文集  2010-  215  -215  2010
• Transdisciplinary Fluid Integration Research Center, Institute of Fluid Science, Tohoku University

  SHIRAI Atsushi  計測と制御  48-  (3)  288  -289  2009/03
• 212 Measurement of Friction Characteristics of Neutrophil on Endothelial Cells with the Inclined Centrifuge Microscope

  UMIMOTO Takashi; SHIRAI Atsushi; HAYASE Toshiyuki  バイオエンジニアリング講演会講演論文集  2008-  (21)  81  -82  2009/01
• Modeling neutrophil transport in pulmonary capillaries

  Atsushi Shirai  Respiratory Physiology & Neurobiology  163-  (1-3)  158  -165  2008/11  [Invited]
  
• A316 Measurement of Friction Characteristics of Neutrophil on MPC polymer with an Inclined Centrifuge Microscope

  UMIMOTO Takashi; SHIRAI Atsushi; HAYASE Toshiyuki  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2008-  (19)  111  -112  2008/09
• (1)Transit Characteristics of a Neutrophil Passing through Two Moderate Constrictions in a Cylindrical Capillary Vessel : Effect of Cell Deformation on Transit through the Second Constriction

  白井 敦; 藤田 亮; 早瀬 敏幸  Journal of the Japan Society of Mechanical Engineers  110-  (1062)  339  -339  2007/05
• 鍼灸所見の臨床的意義と客観化 六部定位の脈診について 脈波情報の客観化と脈診 (全日本鍼灸学会雑誌)

  丸山満也; 金野敏; 仁田新一; 高島充; 白石泰之; 山家智之; 関隆志; 荒井啓行; 太田信; 劉磊; 白井敦; 早瀬敏幸  全日本鍼灸学会雑誌  57-  (2)  116  -118  2007/05
• 157 Measurement of fluid velocity of blood cell in microchannel with observation system

  ASAHINA Sho; SHIRAI Atsushi; HAYASE Toshiyuki  講演論文集  2007-  (42)  113  -114  2007/03
• 161 Basic Study for Development of Numerical Model of the Pulse Diagnosis

  NARUMI Kentarou; NAKANISHI Tsutomu; LIU Lei; SHIRAI Atsushi; HAYASE Toshiyuki; OHTA Makoto; KONNO Satoshi; KAWATA Hiroshi; MARUYAMA Mitsuya; NITTA Shin-ichi  講演論文集  2007-  (42)  121  -122  2007/03
• B110 Development of observation System of Neutrophils Transit in Microchannel : Prevention of Adhesion of the Cells on Microchannel by MPC Coating

  ASAHINA Sho; SHIRAI Atsushi; HAYASE Toshiyuki  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2006-  (17)  59  -60  2006/11
• 818 Effect of Mechanical Properties of Neutrophils on Their Transit Time through a Capillary Network(1)

  SHIRAI Atsushi; HAYASE Toshiyuki  Fluids engineering conference ...  2006-  "818  -a"  2006/10
• 818 Effect of Mechanical Properties of Neutrophils on Their Transit Time through a Capillary Network(2)

  SHIRAI Atsushi; HAYASE Toshiyuki  Fluids engineering conference ...  2006-  "818  -1"-"818-4"  2006/10
• B108 Development and Experimental Validation of Mathematical Model for Acquisition of Information in Pulse Diagnosis

  NARUMI Kentarou; SHIRAISHI Mitsuya; NITTA Shin-ichi; NAKANISHI Tsutomu; LIU Lei; INOUE Kosuke; SHIRAI Atsushi; HAYASE Toshiyuki; OHTA Makoto; KONNO Satoshi; KAWATA Hiroshi  The Proceedings of the JSME Conference on Frontiers in Bioengineering  2006-  (0)  55  -56  2006
• B210 Numerical Analysis for Increase in Concentration of Neutrophils in Capillary Network

  SHIRAI Atsushi; HAYASE Toshiyuki  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2005-  (16)  147  -148  2005/11
• AM05-17-022 Numerical Simulation for Concentration Distribution of Neutrophils in Caoillary Network

  SHIRAI Atsushi; HAYASE Toshiyuki  日本流体力学会年会講演論文集  2005-  313  -313  2005
• Ultrasonic-Measurement-Integrated Simulation for Blood Flows 2^ Report : Reproduction of Blood Flow in Aorta

  FUNAMOTO Kenichi; HAYASE Toshiyuki; SHIRAI Atsushi; YAMBE Tomoyuki; SAIJO Yoshifumi  バイオエンジニアリング講演会講演論文集  2004-  (16)  165  -166  2004/01
• Time Variation of the Maximum Radius of a Deformed Neutrophil that has Passed through a Narrow Capillary

  SHIRAI Atsushi; FUJITA Ryo; HAYASE Toshiyuki  バイオエンジニアリング講演会講演論文集  2004-  (16)  179  -180  2004/01
• B322 Measurement of Frictional Characteristics of Cells Using Inclined Centrifuge Microscope

  HAYASE Toshiyuki; SAITO Kotomi; YAMAGATA Takayuki; INOUE Kosuke; SHIRAI Atsushi  日本流体力学会年会講演論文集  2004-  534  -535  2004
• B324 Study of Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow

  FUNAMOTO Kenichi; HAYASE Toshiyuki; SHIRAI Atsushi; SAIJO Yoshifumi; YAMBE Tomoyuki  日本流体力学会年会講演論文集  2004-  538  -539  2004
• B323 Numerical Simulation of Neutrophils Flow in Capillary Network

  SHIRAI Atsushi; FUJITA Ryo; HAYASE Toshiyuki  日本流体力学会年会講演論文集  2004-  536  -537  2004
• Improvement of Accuracy of Measurement for Frictional Characteristics of Red Blood Cells with Inclined Centrifuge Microscope by Image Processing Technique

  半澤 徹; 早瀬 敏幸; 白井 敦; 濱谷 剛  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  2003-  (14)  27  -28  2003/09
• Ultrasonic-Measurement-Integrated Simulation for Blood Flows : 1^ Report : Reduction of Error Originating from Upstream Boundary Condition

  FUNAMOTO Kenichi; HAYASE Toshiyuki; SHIRAI Atsushi; YAMBE Tomoyuki; SAIJO Yoshifumi  Proceedings of the ... JSME Conference on Frontiers in Bioengineering  1-  83  -84  2003
• 有限要素法による流れ解析

  白井敦  フルードパワーシステム  33-  (7)  420  -425  2002/11
• Fundamental Study of Hybrid Wind Tunnel : Investigation of Realtime Analysis

  NISUGI Keisuke; HAYASE Toshiyuki; SHIRAI Atsushi  講演論文集  2002-  105  -106  2002/09
• Fundamental Study on Hybrid Wind Tunnel : Investigation of Feedback Scheme

  TAKEDA Shinpei; NISUGI Keisuke; SHIRAI Atsushi; HAYASE Toshiyuki  講演論文集  2002-  (37)  32  -33  2002/03
• Numerical Simulation of Flow in Right Angle Branch : Mechanism of Unstable Oscillation

  NAITO Taiki; HAYASE Toshiyuki; SHIRAI Atsushi; YAMAGUCHI Ryuhei  講演論文集  2002-  (37)  44  -45  2002/03
• Flow of Neutrophils through Two Constrictions in a Fine Capillary

  SHIRAI Atsushi; FUJITA Ryo; HAYASE Toshiyuki  バイオエンジニアリング講演会講演論文集  2002-  (14)  133  -134  2002/03
• Transit of a Deformed Neutrophil through a Constriction in a Fine Capillary : Effect of Throat Radius of Constriction on Transit Time

  FUJITA Ryo; SHIRAI Atsushi; HAYASE Toshiyuki  日本流体力学会年会講演論文集  2002-  302  -303  2002
• Measurement of Frictional Characteristics of Red blood Cells in Small Velocity Regime with Inclined Centrifugal Microscope

  SUGIYAMA Hidekatsu; HAYASE Toshiyuki; SHIRAI Atsushi; HAMAYA Tsuyoshi  日本流体力学会年会講演論文集  2002-  298  -299  2002
• 308 Numerical Simulation of Flow in Right Angle Branch : Spatial Distribution of Unstable Oscillation

  NAITO Taiki; HAYASE Toshiyuki; SHIRAI Atsushi; YAMAGUCHI Ryuhei  Fluids engineering conference ...  2001-  39  -39  2001/09
• 309 Measurement of Flow Characteristics of Red Blood Cells with Inclined Centrifuge Microscope

  HAYASE Toshiyuki; SUGIYAMA Hidekatsu; SHIRAI Atsushi; HAMAYA Tsuyoshi  Fluids engineering conference ...  2001-  40  -40  2001/09
• 305 Numerical Analysis of Deformation of Neutrophils through Stenotic Capillaries

  SHIRAI Atsushi; FUJITA Ryo; HAYASE Toshiyuki  Fluids engineering conference ...  2001-  37  -37  2001/09
• G804 Fundamental Study on Hybrid Wind Tunnel : Evaluation of the Estimation Performance

  TAKEDA Shinpei; NISUGI Keisuke; SHIRAI Atsushi; HAYASE Toshiyuki  Fluids engineering conference ...  2001-  236  -236  2001/09
• G803 Fundamental Study on Hybrid Wind Tunnel : Study of Feedback Scheme

  NISUGI Keisuke; TAKEDA Shinpei; SHIRAI Atsushi; HAYASE Toshiyuki  Fluids engineering conference ...  2001-  235  -235  2001/09
• 肺の毛細血管における血漿流動と好中球変形の連成問題

  白井敦  日本数値流体力学会誌  9-  (4)  106  -111  2001/08  [Invited]
  
• Numerical Simulation of Flow in Right Angle Branch : Simulation in the Whole Region of Sharp Edged Branch

  NAITO Taiki; HAYASE Toshiyuki; SHIRAI Atsushi; YAMAGUCHI Ryuhei  バイオエンジニアリング講演会講演論文集  2001-  (13)  76  -77  2001/01
• Measurement of Frictional Characteristics of a Red Blood Cell : Effect of Reaction

  SAKASHITA Shigeto; SHIRAI Atsushi; HAMAYA Tsuyoshi; HAYASE Toshiyuki  バイオエンジニアリング講演会講演論文集  2001-  (13)  12  -13  2001/01
• Numerical Analysis of Flow Control Valve for Water Hydraulics

  林 叡; 白井 敦; 郭 南楠; 早瀬 敏幸  油空圧講演論文集  12-  (2)  97  -99  2000/10
• Eigenvalue Analysis and Non-Linear Phenomena of Direct-Acting Poppet Valve Circuit

  白井 敦; 王 偉民; 林 叡; 早瀬 敏幸  油空圧講演論文集  11-  (2)  3  -4  1999/10
• Drag Reduction of an Automobile by Feedback Control

  仁杉 圭延; 早瀬 敏幸; 白井 敦; 林 叡  油空圧講演論文集  11-  (2)  102  -103  1999/10
• Stability of Direct-Acting Poppet Valve Circuit (Effect of Accumulator on Vibration of the Circuit)

  白井 敦; 林 叡; 早瀬 敏幸; 王 偉民  油空圧講演論文集  11-  (1)  70  -72  1999/05
• Applicability of Lumped Parameter Pipeline Models on Direct-Acting Poppet Valve Circuit

  白井 敦; 林 叡; 早瀬 敏幸; 王 偉民  油空圧講演論文集  10-  (1)  31  -33  1998/05

Industrial Property Rights

• 特許5750805:連続血圧測定システム、連続血圧測定方法、連続血圧測定プログラムおよび、連続血圧測定プログラムを記録したコンピュータ読み取り可能な記録媒体    2015/05/29

  白井敦, 早瀬敏幸
• 特許5751540:血管固さ評価装置、血管固さ評価方法、血管固さ評価プログラムおよび血管固さ評価プログラムを記録したコンピュータ読み取り可能な記録媒体    2015/05/29

  白井敦, 中西勉, 松野史子, 早瀬敏幸
• 特許4269623:血流可視化診断装置  

  早瀬敏幸, 船本健一, 白井敦, 山家智之, 西條芳文  株式会社東北テクノアーチ

Awards & Honors

• 2007/04 (一社)日本機械学会 日本機械学会賞(論文)
   Transit Characteristics of a Neutrophil Passing through Two Moderate Constrictions in a Cylindrical Capillary Vessel (Effect of Cell Deformation on Transit through the Second Constriction) JPN international_academic_award 

  受賞者: 白井敦;藤田亮;早瀬敏幸Transit Characteristics of a Neutrophil Passing through Two Moderate Constrictions in a Cylindrical Capillary Vessel (Effect of Cell Deformation on Transit through the Second Constriction)
• 2002/03 (財)トーキン科学技術振興財団 (財)トーキン科学技術振興財団 第12回(平成13年度)研究奨励賞
   微小血管系における白血球の流動制御に関する研究 JPN publisher 

  受賞者: 白井敦

Research Grants & Projects

• Development of a pulatile VAD having a valve mimicking aortic valve

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2020/04 -2023/03 

  Author : 白井 敦
• 血管内皮の表面幾何形状が好中球のローリング挙動に与える影響に関する実験的研究

  日本学術振興会：平成29年度科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)

  Date (from‐to) : 2017/04 -2020/03 

  Author : 白井 敦
• 好中球ネットーシス上のマイクロ血栓形成メカニズム解明とARDS治療法開発

  日本学術振興会：平成27年度学術研究助成基金助成金 基盤研究(B)

  Date (from‐to) : 2015/04 -2018/03 

  Author : 西堀 正洋
• P-セレクチン上での好中球のローリング特性に与える接触力の影響に関する実験的研究

  日本学術振興会：平成26年度科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)

  Date (from‐to) : 2014/04 -2017/03 

  Author : 白井 敦
• 傾斜遠心顕微鏡を用いた血管表面の凹凸が好中球の挙動に与える影響に関する実験的研究

  日本学術振興会：平成23年度科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)

  Date (from‐to) : 2011/04 -2014/03 

  Author : 白井 敦
• 超音波計測連成解析による超高精度生体機能計測システム

  科学技術振興機構：平成18年度先端計測分析技術・機器開発事業

  Date (from‐to) : 2006/04 -2013/03 

  Author : 早瀬 敏幸
• 超微細超高感度センシングによる疾患の早期発見・兆候検出技術の開発

  文部科学省：平成19年度知的クラスター創成事業(第2期)

  Date (from‐to) : 2007/04 -2012/03
• 傾斜遠心顕微鏡を用いた血球の固体壁に対する付着特性の定量評価に関する研究

  日本学術振興会：平成21年度科学研究費補助金 若手研究(B)

  Date (from‐to) : 2009/04 -2011/03 

  Author : 白井 敦
• 計測融合連成解析による生体内血流場の経時的挙動の解明

  日本学術振興会：平成19年度科学研究費補助金 基盤研究(B)

  Date (from‐to) : 2007/04 -2010/03 

  Author : 早瀬 敏幸
• 毛細血管網における血球の変形・流動特性の微小流路を用いた実験的研究

  日本学術振興会：平成17年度科学研究費補助金 若手研究(B)

  Date (from‐to) : 2005/04 -2007/03 

  Author : 白井 敦
• 微小血管網における血球の変形とその流動に関する実験的研究

  日本学術振興会：平成15年度科学研究費補助金 若手研究(B)

  Date (from‐to) : 2003/04 -2005/03 

  Author : 白井 敦
• 微小血管における好中球の流動特性および変形挙動に関する実験的研究

  (財)新世代研究所：平成14年度研究助成

  Date (from‐to) : 2002/04 -2003/03 

  Author : 白井 敦
• 血球の変形挙動に与える固体壁の影響に関する実験的研究

  日本学術振興会：平成13年度科学研究費補助金 奨励研究(A)

  Date (from‐to) : 2001/04 -2003/03 

  Author : 白井 敦
• 毛細血管内におけるがん細胞流動の定量的な記述が可能なミクロ生体流動モデルの構築

  日本学術振興会：平成12年度科学研究補助金 萌芽的研究

  Date (from‐to) : 2000/04 -2002/03 

  Author : 早瀬 敏幸
• 赤血球の三次元挙動に与える固体壁の影響に関する実験的研究

  日本学術振興会：平成12年度科学研究費補助金 奨励研究(A)

  Date (from‐to) : 2000/04 -2001/03 

  Author : 白井 敦
• 毛細血管内の赤血球の流動特性とその機能性に関する研究

  日本学術振興会：平成7年度日本学術振興会特別研究員奨励費(DC1)

  Date (from‐to) : 1995/04 -1998/03 

  Author : 白井 敦

Social Contribution

• 広島県立黒瀬高等学校 模擬授業

  Date (from-to) : 2020/10/28-2020/10/28

  Role : Lecturer

  Sponser, Organizer, Publisher  : 近畿大学工学部
• 平成25年度みやぎ県民大学 東北大学流体科学研究所開放講座

  Date (from-to) : 2013/07/05

  Role : Lecturer 「血液の流れ」と題して，一般市民に対して血液の流れに関する講演を行った．
• 平成22年度みやぎ県民大学 東北大学流体科学研究所開放講座

  Date (from-to) : 2010/09/03

  Role : Lecturer 「第2回：血液の流れ」と題して，一般市民に対して血液の流れに関する講演を行った．
• 平成20年度みやぎ県民大学 東北大学流体科学研究所開放講座

  Date (from-to) : 2008/09/19

  Role : Lecturer 「第2回：血液の流れ」と題して，一般市民に対して血液の流れに関する講演を行った．

Media Coverage

• 血管モデル活用し、経験に基づく東洋医学を科学的に解明

  Date : 2010

  Publisher, broadcasting station: (株)アイグラフ

  Program, newspaper magazine: 仙台トラビス, Vol. 19 (2010 Spring)

  特別付録「健康REPORT2010」 Paper

Others

• 2014/04 -2014/04  鍼刺激による血流動態変化の検証 

  伝統中国医学の一つである鍼治療において，刺鍼による刺激が血行動態に影響を与えることが実験的に確かめられた．しかし，その機序についてはまだ仮定の段階であるため，数値解析によって物理的側面から刺鍼による血行動態変化を解析する．
• 2013/04 -2013/04  血管内皮細胞の表面幾何形状が好中球のローリングに与える影響に関するin vitro実験 

  好中球の免疫反応プロセスにおいて，血管内非常におけるローリング挙動が最初期の反応として注目されている．これまでは接着分子の寄与に注目した研究が殆どであったが，血管内皮表面の幾何形状もその挙動に大きな影響を与えると考えられる．そこで，PDMSを用いてこの表面形状を模擬し，好中球の挙動に与える表面形状の影響を実験的に解析する．
• 2011/10 -2011/10  水棲微生物の推進に関する数値解析 

  数mmから数cmオーダの水棲微生物に特有な繊毛を有する遊泳脚の推進機構を解明する．
• 2007/10 -2007/10  先進予防型健康社会仙台クラスター 

  近年の少子・高齢化社会の急速な進展は，対応する社会システムやインフラの整備が追いつかない中で，医療費・介護費等の増加が指摘されている．こうした中で，コスト増を防ぎつつ市民の安全，安心かつ健康な生活を実現するためには，これまでの疾病等にかかってからの治療(2次，3次予防)に替えて，疾病等の発生そのものを予防する1次予防の取り組みを強化する必要がある．そこで，東北大学，東北福祉大学等の先端的な研究資源を活用し，先進的な予防の実現に資する研究開発，実証を行うことで先進的疾病予防・健康維持に関する知見の集積およびそれを活用した疾病予防・健康維持のためのサービス・機器開発を目指す産業の形成を図り，これによって市民の健康の質の向上，行政コストの効率化および地域経済の活性化をバランス良く成立させることを目指します．
• 2006/12 -2006/12  高精度血球変形観察システム 

  ハイスピードビデオカメラを用いた微小流路における血球流動観察システムの開発
• 2006/12 -2006/12  PDMS微小流路作成システム 

  PDMSによる微小流路を作成する
• 2006/10 -2006/10  超音波計測連成解析による超高精度生体機能計測システム 

  機器開発プログラム(領域特定型)「ハードウェアによる計測限界を突破するためのコンピュータ融合型計測分析システム」
• 2006/09 -2006/09  超音波を利用した非侵襲的骨切除システムの開発 

  超音波を利用して非侵襲的に骨を切除するシステムの開発
• 2005/08 -2005/08  脈診を参考にした，脈波計測による病変診断システムの開発 

  脈波計測による病変診断システム開発において，腕部血管系の血流シミュレーションモデル構築
• 2003/04 -2003/04  血球流動観察システム 

  平成14年度からの継続
• 2002/04 -2002/04  微小血管における好中球の流動特性および変形挙動に関する実験的研究 

  顕微鏡下における好中球流動および変形能の観察
• 2002/04 -2002/04  血球流動観察システム 

  顕微鏡下における血球の流動特性を観察するシステムの開発
• 2000/06 -2000/06  肺毛細血管内における好中球の流動特性に関する数値解析 

  肺の毛細血管における好中球の流動特性の数値解析

Other link

researchmap

https://researchmap.jp/a_shirai