Advance

IKEDA Hiroko

    Department of Life Science　Research associate
Last Updated :2024/04/25

Researcher Information

Degree

  • Ph.D. (Medicine)（Gunma University）

Research funding number

  • 90806465

J-Global ID

Research Interests

  • Cell biology   Bystander effect   Radiation biology   

Research Areas

  • Environmental science/Agricultural science / Environmental effects of radiation
  • Life sciences / Radiology

Academic & Professional Experience

  • 2020/04 - Today  Kindai UniversityFaculty of Science and Engineering, Department of Life ScienceAssistant professor
  • 2017/04 - 2020/03  Gunma University Initiative for Advanced ResearchInternational Open Laboratory (Dr. Held lab, Harvard Medical School / MGH)Postdoctoral researcher

Education

  • 2012/04 - 2017/03  Gunma University Graduate School of Medicine  医学系研究科  PhD Course of Medical Sciences
  • 2010/04 - 2012/03  Gunma University Graduate School of Medicine  医学系研究科  Master Course of Biomedical Sciences
  • 2006/04 - 2010/03  Kindai University  Faculty of Science and Engineering  Department of Life Science

Association Memberships

  • YOUNG RADIATION BIOLOGISTS' ASSOCIATION OF JAPAN   THE JAPAN MICROBEAM BIOLOGY RESEARCH ASSOCIATION   THE JAPANESE SOCIETY FOR BIOLOGICAL SCIENCES IN SPACE   THE JAPANESE RADIATION RESEARCH SOCIETY   日本量子医科学会   日本癌学会   

Published Papers

  • Hiroko Ikeda; Miwa Takai; Narumi Yashiro; Yuka Amano; Koki Hara; Mao Yamamoto; Toshifumi Tsujiuchi
    Pathology - Research and Practice Elsevier BV 257 155293 - 155293 0344-0338 2024/05 [Refereed]
  • Nho Cong Luong; Hidemasa Kawamura; Hiroko Ikeda; Reiko T. Roppongi; Atsushi Shibata; Jiaxuan Hu; Jinmeng G. Jiang; David S. Yu; Kathryn D. Held
    International Journal of Radiation Biology Informa UK Limited 1 - 12 0955-3002 2024/03 [Refereed]
  • Hiroko Ikeda; Miwa Takai; Toshifumi Tsujiuchi
    Advances in Biological Regulation Elsevier BV 92 101029 - 101029 2212-4926 2024/02 [Refereed]
  • Polina Malatesta; Konstantinos Kyriakidis; Megumi Hada; Hiroko Ikeda; Akihisa Takahashi; Premkumar B. Saganti; Alexandros G. Georgakilas; Ioannis Michalopoulos
    Biomolecules MDPI AG 14 (1) 88  2024/01 [Refereed]
     
    During future space missions, astronauts will be exposed to cosmic radiation and microgravity (μG), which are known to be health risk factors. To examine the differentially expressed genes (DEG) and their prevalent biological processes and pathways as a response to these two risk factors simultaneously, 1BR-hTERT human fibroblast cells were cultured under 1 gravity (1G) or simulated μG for 48 h in total and collected at 0 (sham irradiated), 3 or 24 h after 1 Gy of X-ray or Carbon-ion (C-ion) irradiation. A three-dimensional clinostat was used for the simulation of μG and the simultaneous radiation exposure of the samples. The RNA-seq method was used to produce lists of differentially expressed genes between different environmental conditions. Over-representation analyses were performed and the enriched biological pathways and targeting transcription factors were identified. Comparing sham-irradiated cells under simulated μG and 1G conditions, terms related to response to oxygen levels and muscle contraction were identified. After irradiation with X-rays or C-ions under 1G, identified DEGs were found to be involved in DNA damage repair, signal transduction by p53 class mediator, cell cycle arrest and apoptosis pathways. The same enriched pathways emerged when cells were irradiated under simulated μG condition. Nevertheless, the combined effect attenuated the transcriptional response to irradiation which may pose a subtle risk in space flights.
  • Aya Okuda; Miwa Takai; Rio Kurisu; Miyu Takamoto; Hiroko Ikeda; Toshifumi Tsujiuchi
    International Journal of Radiation Biology Informa UK Limited 99 (12) 1925 - 1933 0955-3002 2023/08 [Refereed]
  • Kanako Minami; Nanami Ueda; Kaichi Ishimoto; Rio Kurisu; Miyu Takamoto; Hiroko Ikeda; Toshifumi Tsujiuchi
    Experimental and Molecular Pathology Elsevier BV 118 104596 - 104596 0014-4800 2021/02 [Refereed]
  • Kanako Minami; Nanami Ueda; Kaichi Ishimoto; Rio Kurisu; Miyu Takamoto; Hiroko Ikeda; Toshifumi Tsujiuchi
    Biochemical and Biophysical Research Communications Elsevier BV 532 (3) 427 - 432 0006-291X 2020/11 [Refereed]
  • Hiroko Ikeda; Masafumi Muratani; Jun Hidema; Megumi Hada; Keigi Fujiwara; Hikaru Souda; Yukari Yoshida; Akihisa Takahashi
    International Journal of Molecular Sciences MDPI AG 20 (19) 4791  2019/09 [Refereed]
     
    Multiple unique environmental factors such as space radiation and microgravity (μG) pose a serious threat to human gene stability during space travel. Recently, we reported that simultaneous exposure of human fibroblasts to simulated μG and radiation results in more chromosomal aberrations than in cells exposed to radiation alone. However, the mechanisms behind this remain unknown. The purpose of this study was thus to obtain comprehensive data on gene expression using a three-dimensional clinostat synchronized to a carbon (C)-ion or X-ray irradiation system. Human fibroblasts (1BR-hTERT) were maintained under standing or rotating conditions for 3 or 24 h after synchronized C-ion or X-ray irradiation at 1 Gy as part of a total culture time of 2 days. Among 57,773 genes analyzed with RNA sequencing, we focused particularly on the expression of 82 cell cycle-related genes after exposure to the radiation and simulated μG. The expression of cell cycle-suppressing genes (ABL1 and CDKN1A) decreased and that of cell cycle-promoting genes (CCNB1, CCND1, KPNA2, MCM4, MKI67, and STMN1) increased after C-ion irradiation under μG. The cell may pass through the G1/S and G2 checkpoints with DNA damage due to the combined effects of C-ions and μG, suggesting that increased genomic instability might occur in space.
  • Megumi Hada; Hiroko Ikeda; Jordan Rhone; Andrew Beitman; Ianik Plante; Hikaru Souda; Yukari Yoshida; Kathryn Held; Keigi Fujiwara; Premkumar Saganti; Akihisa Takahashi
    International Journal of Molecular Sciences MDPI AG 20 (1) 43  2018/12 [Refereed]
     
    Space radiation and microgravity (μG) are two major environmental stressors for humans in space travel. One of the fundamental questions in space biology research is whether the combined effects of μG and exposure to cosmic radiation are interactive. While studies addressing this question have been carried out for half a century in space or using simulated μG on the ground, the reported results are ambiguous. For the assessment and management of human health risks in future Moon and Mars missions, it is necessary to obtain more basic data on the molecular and cellular responses to the combined effects of radiation and µG. Recently we incorporated a μG–irradiation system consisting of a 3D clinostat synchronized to a carbon-ion or X-ray irradiation system. Our new experimental setup allows us to avoid stopping clinostat rotation during irradiation, which was required in all other previous experiments. Using this system, human fibroblasts were exposed to X-rays or carbon ions under the simulated μG condition, and chromosomes were collected with the premature chromosome condensation method in the first mitosis. Chromosome aberrations (CA) were quantified by the 3-color fluorescent in situ hybridization (FISH) method. Cells exposed to irradiation under the simulated μG condition showed a higher frequency of both simple and complex types of CA compared to cells irradiated under the static condition by either X-rays or carbon ions.
  • Performance evaluation of new devices to synchronize heavy-ion or X-ray irradiation and simulated microgravity for space radiation research ~ Improvement of a control stage ~.
    Takahashi A; Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T
    The 31st International Symposium on Space Technology and Science (ISTS), proceeding (Theses ID: 2017-p-09) 2018 [Refereed]
  • Role of High-Linear Energy Transfer Radiobiology in Space Radiation Exposure Risks.
    Takahashi A; Ikeda H; Yoshida Y
    Int J Particle Ther. 5 (1) 151 - 159 2018 [Refereed]
  • Hiroko Ikeda; Hikaru Souda; Anggraeini Puspitasari; Kathryn D. Held; Jun Hidema; Takeshi Nikawa; Yukari Yoshida; Tatsuaki Kanai; Akihisa Takahashi
    Life Sciences in Space Research Elsevier BV 12 51 - 60 2214-5524 2017/02 [Refereed]
  • Hiroko Ikeda; Hikaru Souda; Anggraeini Puspitasari; Kathryn D. Held; Jun Hidema; Takeshi Nikawa; Yukari Yoshida; Tatsuaki Kanai; Akihisa Takahashi
    Biological Sciences in Space Japanese Society for Biological Sciences in Space 30 (0) 8 - 16 0914-9201 2016/12 [Refereed]
     
    Considering further human activity in space, it is necessary to study the biological effects of combined microgravity and space radiation; however, many aspects of these combined effects remain unclear. In the field of space biology, it is difficult to investigate relative biological effectiveness (RBE) and combined effects because the ability to conduct and replicate space experiments is restricted. Therefore, a new three-dimensional (3D) clinostat synchronized X-irradiation system with a high-speed shutter was fabricated following the development of a heavy-ion irradiation system. This study showed that the system could simultaneously irradiate rotating samples using the 3D clinostat, with the samples in a horizontal position. The samples were completely irradiated because of the flatness and symmetry of the irradiation fields. Doses were virtually identical under both standing and rotation conditions, with the difference being <1% under the assumption of X-irradiation at a dose of 1 Gy. Our new device could accurately synchronize X-irradiation and simulated microgravity at the ground level. The device is expected to greatly contribute to space radiation research as a valuable platform for studies concerning RBE and the combined effects of radiation under microgravity.
  • Yuichiro Yokota; Tomoo Funayama; Yasuko Mutou-Yoshihara; Hiroko Ikeda; Yasuhiko Kobayashi
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY INFORMA HEALTHCARE 91 (5) 383 - 388 0955-3002 2015/05 [Refereed]
     
    Purpose : To investigate the dependence of the bystander cell-killing effect on radiation dose and quality, and to elucidate related molecular mechanisms. Materials and methods : Normal human fibroblast WI-38 cells were irradiated with 0.125 - 2 Gy of gamma-rays or carbon ions and were co-cultured with non-irradiated cells. Survival rates of bystander cells were investigated using the colony formation assays, and nitrite concentrations in the medium were measured using the modified Saltzman method. Results : Survival rates of bystander cells decreased with doses of gamma-rays and carbon ions of <= 0.5 Gy. Treatment of the specific nitric oxide (NO) radical scavenger prevented reductions in survival rates of bystander cells. Moreover, nitrite concentrations increased with doses of less than 0.25 Gy (gamma-rays) and 1 Gy (carbon ions). The dose responses of increased nitrite concentrations as well as survival reduction were similar between gamma-rays and carbon ions. In addition, negative relationships were observed between survival rates and nitrite concentrations. Conclusion : The bystander cell-killing effect mediated by NO radicals in normal human fi broblasts depends on irradiation doses of up to 0.5 Gy, but not on radiation quality. NO radical production appears to be an important determinant of gamma-ray-and carbon-ion-induced bystander effects.
  • Narongchai Autsavapromporn; Masao Suzuki; Tomoo Funayama; Noriko Usami; Ianik Plante; Yuichiro Yokota; Yasuko Mutou; Hiroko Ikeda; Katsumi Kobayashi; Yasuhiko Kobayashi; Yukio Uchihori; Tom K. Hei; Edouard I. Azzam; Takeshi Murakami
    Radiation Research 180 (4) 367 - 375 0033-7587 2013/10 [Refereed]
     
    Understanding the mechanisms underlying the bystander effects of low doses/low fluences of low- or high-linear energy transfer (LET) radiation is relevant to radiotherapy and radiation protection. Here, we investigated the role of gap-junction intercellular communication (GJIC) in the propagation of stressful effects in confluent normal human fibroblast cultures wherein only 0.036-0.144% of cells in the population were traversed by primary radiation tracks. Confluent cells were exposed to graded doses from monochromatic 5.35 keV X ray (LET ∼6 keV/μm), 18.3 MeV/u carbon ion (LET ∼103 keV/μm), 13 MeV/u neon ion (LET ∼380 keV/μm) or 11.5 MeV/u argon ion (LET ∼1,260 keV/μm) microbeams in the presence or absence of 18-α-glycyrrhetinic acid (AGA), an inhibitor of GJIC. After 4 h incubation at 37°C, the cells were subcultured and assayed for micronucleus (MN) formation. Micronuclei were induced in a greater fraction of cells than expected based on the fraction of cells targeted by primary radiation, and the effect occurred in a dose-dependent manner with any of the radiation sources. Interestingly, MN formation for the heavy-ion microbeam irradiation in the absence of AGA was higher than in its presence at high mean absorbed doses. In contrast, there were no significant differences in cell cultures exposed to X-ray microbeam irradiation in presence or absence of AGA. This showed that the inhibition of GJIC depressed the enhancement of MN formation in bystander cells from cultures exposed to high-LET radiation but not low-LET radiation. Bystander cells recipient of growth medium harvested from 5.35 keV X-irradiated cultures experienced stress manifested in the form of excess micronucleus formation. Together, the results support the involvement of both junctional communication and secreted factor(s) in the propagation of radiation-induced stress to bystander cells. They highlight the important role of radiation quality and dose in the observed effects. © 2013 by Radiation Research Society.
  • Naoko Wakabayashi; Megumu Tsujino; Masaki Tajiri; Midori Taki; Ayumi Koshino; Hiroko Ikeda; Nobuyuki Fukushima; Toshifumi Tsujiuchi
    Journal of Toxicologic Pathology 23 (1) 63 - 66 0914-9198 2010/04 [Refereed]
     
    Lysophosphatidic acid (LPA) is a bioactive phospholipid that stimulates cell proliferation and migration, and protects cells from apoptosis. It interacts with specific G protein-coupled transmembrane receptors. Recently, frequent mutations of the LPA receptor-1 (LPA1) gene were detected in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). In this study, to evaluate the involvement of other LPA receptor gene alterations during lung carcinogenesis, we investigated mutations of the LPA2, LPA3, LPA4 and LPA5 genes in lung adenocarcinomas induced by BHP in rats. Fifteen male Wistar rats, 6 weeks of age, were given 2000 ppm BHP in their drinking water for 12 weeks and then maintained without further treatment until sacrifice at 25 weeks, and 15 adenocarcinomas were obtained. Genomic DNAs were extracted from frozen tissues, and the LPA2, LPA3, LPA4 and LPA5 genes were examined for mutations, using polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) analysis. No mutations of LPA2, LPA3, LPA4 and LPA5 were detected in the 15 adenocarcinomas. These results suggest that alterations due to LPA2, LPA3, LPA4 and LPA5 gene mutations might not be involved in the development of lung adenocarcinomas induced by BHP in rats.

Conference Activities & Talks

  • Effects of fractionated X-ray Irradiation on acquired radiation resistance and maintenance of osteosarcoma cells
    池田裕子
    第82回日本癌学会学術総会  2023/09
  • DIFFERENTIAL GENE EXPRESSION IN HUMAN FIBROBLASTS SIMULTANEOUSLY EXPOSED TORADIATION AND SIMULATED MICROGRAVITY
    P. Malatesta; H. Ikeda; A. Takahashi; M. Hada; A. G. Georgakilas; I. Michalopoulos
    2023 NASA Human Research Program Investigators’ Workshop  2023/02
  • CHROMOSOME ABERRATIONS IN HUMAN CELLS INDUCED BY SIMULTANEOUSLY EXPOSED TO PARTIAL GRAVITY AND LOW DOSE-RATE NEUTRONS
    M. Hada; H. Ikeda; J-H Mao; P.B. Saganti; A. Takahashi
    NASA HRP IWS meeting 2023  2023/02
  • Chromosome aberration induction by simulation environment of outer space, Moon and Mars
    Akihisa Takahashi; Hiroko Ikeda; Jian-Hua Mao; Premkumar B. Saganti; Megumi Hada
    第2回日本量子医科学会  2022/12
  • Expression profile of cell cycle / aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity
    Ikeda H; Hada M; Takahashi A
    ASGSR2022  2022/11
  • Increases chromosome aberrations in human cells exposed simultaneously to simulated microgravity and neutron
    M. Hada; H. Ikeda; P.B. Saganti; A. Takahashi
    ASGSR 2022  2022/11
  • The synergistic effects of radiation and simulated microgravity to expression profile changes of cell cycle / aging-related genes in human fibroblasts
    Ikeda H; Hada M; Takahashi A
    日本放射線影響学会第65回大会  2022/09
  • SwiNGを用いた模擬低重力と低線量率中性子線同時曝露による染色体異常誘導
    Akihisa Takahashi; Hiroko Ikeda; Megumi Hada
    日本宇宙生物学会第65回大会  2022/09
  • 宇宙空間、月、火星を模擬した低重力と低線量率中性子線同時曝露による染色体異常誘導
    Akihisa Takahashi; Hiroko Ikeda; Megumi Hada
    日本放射線影響学会第65回大会  2022/09
  • Expression profile of cell cycle or aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity
    Ikeda H; Hada M; Takahashi A
    44th COSPAR Scientific Assembly  2022/07
  • Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity-change (SwiNG)
    Akihisa Takahashi; Hiroko Ikeda; Nagy Lotfy Guiriuis; Yukari Yoshida; Fady; Megumi Hada
    44th COSPAR Scientific Assembly  2022/07
  • Increases chromosome aberrations in human cells exposed to simulated microgravity and radiation simultaneously
    M. Hada; H. Ikeda; J-H. Mao; P.B. Saganti; A. Takahashi
    44th COSPAR Scientific Assembly  2022/07
  • COMPREHENSIVE GENE EXPRESSION ANALYSIS OF HUMAN FIBROBLASTS USING 3D CLINOSTAT SYNCHRONIZED IRRADIATION SYSTEMS  [Not invited]
    Ikeda H; Hada M; Takahashi A
    2022 NASA Human Research Program Investigators’ Workshop  2022/02
  • 宇宙放射線と重力環境変化による複合影響研究 2021年報
    髙橋昭久; 鈴木健之; 鶴岡千鶴; 森岡孝満; 武島嗣英; 吉田由香里; 中村麻子; 池田裕子; 秦恵; 永松愛子; 大平充宣; 稲富裕光; 柿沼志津子
    第36回 宇宙環境利用シンポジウム  2022/01
  • Combined effects of HZE particle and simulated µG on gene expression in human fibroblasts  [Not invited]
    Ikeda H; Hada M; Takahashi A
    日本量子医科学会第1回学術大会  2021/12
  • Increased Chromosome Aberrations in Human Cells Exposed Simultaneously to Simulated Microgravity and Radiation
    Megumi Hada; Sakuya Yamanouchi; Jian Hua Mao; Hiroko Ikeda; Ianik Plante; Premkumar Saganti; Akihisa Takahashi
    2021 American Society for Gravitational and Space Research  2021/11
  • Effects of lysophosphatidic acid (LPA) signaling via LPA2 on the enhancement of chemoresistance in osteosarcoma cells  [Not invited]
    池田裕子; 上田七海; 栗栖梨緒; 高本美友; 辻内俊文
    第80回日本癌学会学術総会  2021/10
  • Increased chromosome aberrations in human cells exposed simultaneously to simulated microgravity and radiationIncreased chromosome aberrations in human cells exposed simultaneously to simulated microg
    Megumi Hada; Sakuya Yamanouchi; Jordan Rhone; Jian-Hua Mao; Hiroko Ikeda; Ianik Plante; Keigi Fujiwara; Premkumar Saganti; Akihisa Takahashi
    NASA HRP-IWS  2021/02
  • 宇宙放射線と重力環境変化による複合影響研究 2020年報
    髙橋昭久; 鈴木健之; 鶴岡千鶴; 森岡孝満; 武島嗣英; 吉田由香里; 中村麻子; 池田裕子; 秦恵; 永松愛子; 大平充宣; 稲富裕光; 柿沼志津子
    第 35 回 宇宙環境利用シンポジウム  2021/01
  • 3D clinostat synchronized irradiation systems and expression profile changes of cell cycle-related genes in human fibroblasts
    Ikeda H; Muratani M; Hidema J; Hada M; Fujiwara K; Souda H; Yoshida Y; Takahashi A
    日本放射線影響学会第63回大会  2020/10
  • RNA sequencing of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity
    Takahashi A; Ikeda H; Muratni M; Hidema J; Fujiwara K; Souda H; Yoshida Y; Hada M
    2020 NASA Human Research Program Investigators' Workshop  2020/01
  • Expression Profile of Cell Cycle-related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity
    Akihisa Takahashi; Hiroko Ikeda; Masafumi Muratani; Jun Hidema; Megumi Hada; Keigi Fujiwara; Hikaru Souda; Yukari Yoshida
    ASGSR2019  2019/11
  • Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and RadiationIncreased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation
    Megumi Hada; Jordan Rhone; Andrew J Beitman; Hiroko Ikeda; Ianik Plante; Hikaru Souda; Yukari Yoshida; Kathryn D Held; Keigi Fujiwara; Premkumar B Saganti; Akihisa Takahashi
    ASGSR2019  2019/11
  • Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation
    Rhone JR; Beitman A; Ikeda H; Souda H; Yoshida Y; Held KD; Fujiwara K; Takahashi A; Saganti PB; Hada M
    2019 NASA Human Research Program Investigators' Workshop  2019/01
  • The synergistic effect of simulated microgravity and charged particle radiation on gene expression in human fibroblasts  [Not invited]
    Ikeda H; Muratani M; Puspitasari A; Held KD; Kawamura H; Hidema J; Yoshida Y; Takahashi A
    COSPAR2018, 42th ASSEMBLY  2018/07
  • Comprehensive gene expression analysis of human fibroblasts using new device to synchronize carbon-ion irradiation and simulated microgravity  [Invited]
    Ikeda H
    Prairie View A&M University (CRI/RaISE Science seminar)  2018/01
  • Development of 3D clinostat synchronized irradiation systems for simulating space conditions  [Not invited]
    Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Hada M; Saganti P; Yoshida Y; Kanai T; Takahashi A
    2018 NASA Human Research Program Investigators’ Workshop  2018/01
  • Importance of the combined effects of radiation and simulated microgravity for space biosciences  [Not invited]
    Ikeda H; Puspitasari A; Held KD; Yoshida Y; Takahashi A
    21st IAA Humans in Space Symposium  2017/11
  • RNAseq profiling to analyze the combined effects on radiation under simulated microgravity for space biosciences  [Not invited]
    Takahashi A; Ikeda H; Muratani M; Puspitasari A; Held KD; Hidema J; Yoshida Y
    63rd Annual RRS Meeting  2017/10
  • 宇宙環境を模擬した疑似微小重力と重粒子線の複合影響による遺伝子発現解析  [Not invited]
    池田裕子; 想田光; 村谷匡史; Puspitasari Anggraeini; HELD Kathryn D; 日出間純; 吉田由香里; 金井達明; 髙橋昭久
    日本放射線影響学会第60回大会  2017/10
  • 放射線が正常脳に及ぼす影響についての研究  [Not invited]
    吉田由香里; Anggraeni Puspitasari; 池田裕子; 中野隆史; 髙橋昭久
    日本宇宙生物科学会第31回大会  2017/09
  • 平成29年度受賞記念講演 (奨励賞) “宇宙環境を模擬した微小重力下の放射線同期照射システムの開発”  [Not invited]
    池田裕子
    日本宇宙生物科学会31回大会  2017/09
  • Performance evaluation of new devices to synchronize X-ray or heavy-ion irradiation and simulated microgravity for space radiation research  [Not invited]
    Takahashi A; Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T
    The 31st International Symposium on Space Technology and Science  2017/06
  • New devices to synchronize irradiation and simulated µG for space radiation research  [Not invited]
    Takahashi A; Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T
    The 5th International Symposium on Space Radiation and Particle Radiotherapy, including the 8th International Workshop on Space Research Radiation (IWSRR) and the 17th Ion Beams in Biology and Medicine (IBIBAM)  2017/05
  • Gene expression profile changes of human fibroblasts using device to synchronize carbon-ion irradiation and simulated microgravity  [Not invited]
    Ikeda H; Muratani M; Puspitasari A; Held KD; Hidema J; Yoshida Y; Takahashi A
    The 5th International Symposium on Space Radiation and Particle Radiotherapy, including the 8th International Workshop on Space Research Radiation (IWSRR) and the 17th Ion Beams in Biology and Medicine (IBIBAM)  2017/05
  • Comprehensive gene expression analysis of human fibroblasts after combined exposure to microgravity and heavy-ions for simulating space conditions  [Not invited]
    Ikeda H; Muratani M; Puspitasari A; Held KD; Hidema J; Yoshida Y; Takahashi A
    The 7th International Society of Radiation Neurobiology Conference  2017/02
  • Effects of oxygen concentration and radiation quality on radiation-induced DNA damage  [Not invited]
    Tominaga S; Okada H; Ikeda H; Yoshida Y; Takahashi A
    The 7th International Society of Radiation Neurobiology Conference  2017/02
  • Development of new devices that analyze the combined effects of radiation and microgravity: 2nd report  [Not invited]
    Takahashi A; Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T
    The 7th International Society of Radiation Neurobiology Conference  2017/02
  • 宇宙環境を模擬した疑似微小重力と重粒子線の複合影響解析  [Not invited]
    髙橋昭久; 池田裕子; 想田光; 村谷匡史; Anggraeini Puspitasari; Kathryn D. Held; 日出間純; 二川健; 吉田由香里; 金井達明
    第10回Quantum Medicine研究会  2017/02
  • Development of 3D-clinostat synchronized heavy-ion irradiation system  [Not invited]
    Ikeda H; Hidema J; Nikawa T; Yoshida Y; Souda H; Kanai T; Takahashi A
    11th Asian Microgravity Symposium  2016/10
  • 擬似微小重力環境における高精度重粒子線同期照射システムの開発  [Not invited]
    髙橋昭久; 池田裕子; 想田光; 金井達明; 吉田由香里; 日出間純; 二川健
    第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会  2016/10
  • 炭素イオン線がん治療の分割照射における治療効果比の基礎的検討  [Not invited]
    吉田由香里; 安藤興一; 小池幸子; 鵜澤玲子; 池田裕子; 八高知子; 髙橋昭久; 金井達明; 中野隆史
    第54回日本放射線腫瘍学会生物部会学術大会  2016/07
  • ヒト正常線維芽細胞においてバイスタンダー効果の誘導に関与する遺伝子の探索  [Not invited]
    横田裕一郎; 舟山知夫; 坂下哲哉; 鈴木芳代; 小林泰彦; 池田裕子
    第10回高崎量子応用研究シンポジウム  2015/10
  • p53タンパクは胞胚期の細胞殺傷を修復し正常な形態形成を進行させるのに必須である  [Not invited]
    保田隆子; 尾田正二; 浅香智美; 永田健斗; 三谷啓志; 舟山知夫; 横田裕一郎; 鈴木芳代; 池田裕子; 小林泰彦
    第10回高崎量子応用研究シンポジウム  2015/10
  • イオンビームとレーザー光照射に対する増感剤投与悪性脳腫瘍C6培養細胞の殺細胞併用増感作用の解明  [Not invited]
    三好憲雄; 池田裕子; 横田裕一郎; 舟山知夫; 小林泰彦
    第10回高崎量子応用研究シンポジウム  2015/10
  • 線虫変異体のマイクロビーム照射に対する化学走性学習応答：その2  [Not invited]
    坂下哲哉; 鈴木芳代; 池田裕子; 服部佑哉; 武藤泰子; 横田裕一郎; 舟山知夫; 小林泰彦; 浜田信行; 白井花菜
    第10回高崎量子応用研究シンポジウム  2015/10
  • Evaluation of survival curves for solid tumor cells after large doses of carbon ion beams and X-rays  [Not invited]
    Yoshida Y; Ando K; Koike S; Yako T; Ikeda H; Uzawa A; Matsumoto T; Isono M; Kanai T; Nakano T
    15th International Congress of Radiation Research  2015/05
  • Bystander cell-killing effect mediated by nitric oxide in nor mal human fibroblasts depends on irradiation dose but not on radiation quality  [Not invited]
    Yokota Y; Funayama T; Ikeda H; Mutoh Yoshihara Y; Suzuki M; Sakashita T; Kobayashi Y
    15th International Congress of Radiation Research  2015/05
  • P53-dependent cell-killing effect via bystander effect using carbon-ion microbeams simulating the spot scanning system with pencil beams at HIMAC  [Not invited]
    Suzuki M; Funayama T; Yokota Y; Suzuki M; Ikeda H; Sakashita T; Kobayashi Y; Murakami T
    15th International Congress of Radiation Research  2015/05
  • Target irradiation of cells and individuals with heavy-ion microbeams of JAEA-Takasaki  [Not invited]
    Funayama T; Yokota Y; Sakashita T; Suzuki M; Ikeda H; Kobayashi Y
    15th International Congress of Radiation Research  2015/05
  • Radiation quality-independent bystander effect and its molecular mechanism  [Not invited]
    Yokota Y; Funayama T; Ikeda H; Mutoh-Yoshihara Y; Suzuki M; Sakashita T; Kobayashi Y
    The 12th International Workshop on Microbeam Probes of Cellular Radiation Response  2015/05
  • Responses of the salt chemotaxis learning in wild type and mutant C. elegans to microbeam irradiation  [Not invited]
    Sakashita T; Suzuki M; Hattori Y; Ikeda H; Mutou Y; Yokota Y; Funayama T; Hamada N; Shirai K; Kobayashi Y
    15th International Congress of Radiation Research  2015/05
  • The systemic effects of irradiation revealed by the local irradiation to the medaka testis using carbon-ion micro-beam system in TIARA  [Not invited]
    Oda S; Yasuda T; Watanabe-Asaka T; Ikeda H; Muto Y; Yokota Y; Sakashita T; Suzuki M; Funayama T; Kobayashi Y; Mitani H
    The 12th International Workshop on Microbeam Probes of Cellular Radiation Response  2015/05
  • Analysis of medium-mediated bystander effects induced by carbon-ion irradiation between human lung normal and cancer cells  [Not invited]
    Ikeda H; Yokota Y; Funayama T; Kanai T; Nakano T; Kobayashi Y
    15th International Congress of Radiation Research  2015/05
  • Patterning irradiation for contact co-culture of different type cells using heavy-ion microbeam  [Not invited]
    Ikeda H; Yokota Y; Funayama T; Kanai T; Nakano T; Kobayashi Y
    The 12th International Workshop on Microbeam Probes of Cellular Radiation Response  2015/05
  • Responses of the salt chemotaxis learning in wild type and mutant C. elegans to microbeam irradiation  [Not invited]
    Sakashita T; Suzuki M; Hattori Y; Ikeda H; Mutou Y; Yokota Y; Funayama T; Hamada N; Shirai K; Kobayashi Y
    The 5th International Society of Radiation Neurobiology Conference  2015/02
  • ヒト正常線維芽細胞において一酸化窒素ラジカルが媒介するバイスタンダー細胞致死効果は線質に依存しない  [Not invited]
    横田裕一郎; 舟山知夫; 池田裕子; 坂下哲哉; 鈴木芳代; 小林泰彦
    日本放射線影響学会第57回大会  2014/10
  • マイクロビーム照射されたメダカ胚盤細胞の全能性  [Not invited]
    保田隆子; 尾田正二; 浅香智美; 永田健斗; 三谷啓志; 舟山知夫; 横田裕一郎; 鈴木芳代; 池田裕子; 小林泰彦
    第9回高崎量子応用研究シンポジウム  2014/10
  • 放射線誘発バイスタンダー応答による放射線適応応答の誘導メカニズム  [Not invited]
    松本英樹; 冨田雅典; 大塚健介; 畑下昌範; 前田宗利; 舟山知夫; 横田裕一郎; 鈴木芳代; 坂下哲哉; 池田裕子; 小林泰彦
    第9回高崎量子応用研究シンポジウム  2014/10
  • 線虫の筋運動に対する炭素イオンマイクロビーム局部照射の影響  [Not invited]
    鈴木芳代; 坂下哲哉; 舟山知夫; 横田裕一郎; 池田裕子; 小林泰彦; 服部佑哉
    第9回高崎量子応用研究シンポジウム  2014/10
  • アルゴンイオンによる液性因子を介した細胞致死効果のバイスタンダー効果誘導  [Not invited]
    鈴木雅雄; 舟山知夫; 横田裕一郎; 鈴木芳代; 池田裕子; 武藤泰子; 服部佑哉; 坂下哲哉; 小林泰彦
    第9回高崎量子応用研究シンポジウム  2014/10
  • マイクロビーム照射に対する線虫変異体の化学走性学習の応答  [Not invited]
    坂下哲哉; 鈴木芳代; 池田裕子; 武藤泰子; 横田裕一郎; 舟山知夫; 小林泰彦; 服部佑哉; 浜田信行; 白井花菜
    第9回高崎量子応用研究シンポジウム  2014/10
  • 培養液経由による炭素線誘発異細胞種間バイスタンダー効果の解析  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 小林泰彦; 金井達明
    第9回高崎量子応用研究シンポジウム  2014/10
  • バイスタンダー効果の線量応答と分子機構  [Not invited]
    横田裕一郎; 舟山知夫; 坂下哲哉; 鈴木芳代; 小林泰彦; 池田裕子
    第9回高崎量子応用研究シンポジウム  2014/10
  • 重粒子線がん治療の至適分割照射法開発のための基礎的研究  [Not invited]
    吉田由香里; 安藤興一; 小池幸子; 鵜澤玲子; 磯野真由; 池田裕子; 溝端健亮; 金井達明; 大野達也; 中野隆史
    日本放射線影響学会第57回大会  2014/10
  • ヒト肺由来の異細胞種間バイスタンダー効果における線量応答の解析  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 金井達明; 中野隆史; 小林泰彦
    日本放射線影響学会第57回大会  2014/10
  • 線虫変異体の化学走性学習に対する重イオンマイクロビーム局部照射の影響  [Not invited]
    坂下哲哉; 鈴木芳代; 服部佑哉; 池田裕子; 武藤泰子; 横田裕一郎; 舟山知夫; 浜田信行; 白井花菜; 小林泰彦
    日本宇宙生物科学会第28回大会  2014/09
  • Bystander cell-killing effect mediated by nitric oxide in normal human fibroblasts depends in part on irradiation dose but not on radiation quality  [Not invited]
    Yokota Y; Funayama T; Ikeda H; Kobayashi Y
    The 60th Annual Meeting of the Radiation Research Society  2014/09
  • マイクロビームを用いた個体レベル放射線影響の解析 -放射線影響の照射部位依存性に迫る-  [Not invited]
    鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 池田裕子; 小林泰彦
    第4回国際放射線神経生物学会大会  2014/01
  • 原子力機構・高崎における重イオンマイクロビーム照射技術開発の現状  [Not invited]
    舟山知夫; 横田裕一郎; 坂下哲哉; 鈴木芳代; 池田裕子; 小林泰彦
    日本放射線影響学会第56回大会  2013/10
  • 重イオンとガンマ線により誘発されるバイスタンダー効果の解析研究：バイスタンダー効果は線量に部分的に依存するが線質に依存しない  [Not invited]
    横田裕一郎; 舟山知夫; 鈴木芳代; 坂下哲哉; 小林泰彦; 池田裕子
    第8回高崎量子応用研究シンポジウム  2013/10
  • メダカ胚をモデルとした着床前期胚の放射線影響  [Not invited]
    保田隆子; 尾田正二; 大西壽子; 三谷啓志; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    第8回高崎量子応用研究シンポジウム  2013/10
  • 線虫の咽頭ポンピング運動に対する放射線影響の照射部位依存性  [Not invited]
    鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 池田裕子; 小林泰彦
    第8回高崎量子応用研究シンポジウム  2013/10
  • バイスタンダー効果で誘導されるヒト正常細胞の染色体異常誘発効果の線量効果関係  [Not invited]
    鈴木雅雄; Autsavapromporn N; 舟山知夫; 横田裕一郎; 武藤泰子; 鈴木芳代; 池田裕子; 服部佑哉; 坂下哲哉; 小林泰彦
    第8回高崎量子応用研究シンポジウム  2013/10
  • マイクロビーム照射に対するMock条件付け線虫の化学走性の応答  [Not invited]
    坂下哲哉; 下澤容子; 鈴木芳代; 服部佑哉; 池田裕子; 武藤泰子; 横田裕一郎; 舟山知夫; 小林泰彦; 浜田信行; 白井花菜
    第8回高崎量子応用研究シンポジウム  2013/10
  • 重イオンとガンマ線により誘発されるバイスタンダー効果の線質依存性と時間依存性の解析  [Not invited]
    横田裕一郎; 舟山知夫; 池田裕子; 武藤泰子; 鈴木芳代; 坂下哲哉; 小林泰彦
    日本放射線影響学会第56回大会  2013/10
  • 原子力機構・高崎の生物照射用マイクロビーム装置  [Not invited]
    舟山知夫; 横田裕一郎; 鈴木芳代; 池田裕子; 坂下哲哉; 小林泰彦
    日本マイクロビーム生物研究会第4回連絡会議（日本放射線影響学会第56回大会・ランチョンセミナー）  2013/10
  • 線虫の筋運動に対する重イオンマイクロビーム局部照射の影響  [Not invited]
    鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 池田裕子; 小林泰彦
    日本放射線影響学会第56回大会  2013/10
  • アルゴンイオンマイクロビーム照射で誘導される細胞死効果のバイスタンダー効果  [Not invited]
    鈴木雅雄; Autsavapromporn N; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 鈴木芳代; 服部佑哉; 坂下哲哉; 小林泰彦; 村上健
    日本放射線影響学会第56回大会  2013/10
  • マイクロビームを用いた精巣選択的照射のメダカ生体への影響  [Not invited]
    尾田正二; 保田隆子; 浅香智美; 三谷啓志; 池田裕子; 武藤泰子; 横田裕一郎; 鈴木芳代; 舟山知夫; 小林泰彦
    日本放射線影響学会第56回大会  2013/10
  • 異細胞種間における重粒子線誘発バイスタンダー効果  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 小林泰彦; 金井達明
    第8回高崎量子応用研究シンポジウム  2013/10
  • 異細胞種間および同細胞種間における炭素線誘発バイスタンダー効果の解析  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 金井達明; 小林泰彦
    日本放射線影響学会第56回大会  2013/10
  • Effects of carbon-ion microbeam irradiation on locomotion and pharyngeal pumping in C. elegans  [Not invited]
    Suzuki M; Hattori Y; Sakashita T; Funayama T; Yokota Y; Ikeda H; Kobayashi Y
    11th International Workshop on Microbeam Probes of Cellular Radiation Response  2013/10
  • Analysis of bystander effects induced by heavy ions and gamma-rays  [Not invited]
    Yokota Y; Funayama T; Ikeda H; Mutoh-Yoshihara Y; Suzuki M; Sakashita T; Kobayashi Y
    11th International Workshop on Microbeam Probes of Cellular Radiation Response  2013/10
  • Recent progress in development of heavy-ion microbeam systems of JAEA-Takasaki  [Not invited]
    Funayama T; Yokota Y; Suzuki M; Ikeda H; Sakashita T; Kobayashi Y
    11th International Workshop on Microbeam Probes of Cellular Radiation Response  2013/10
  • Establishment of experimental systems for analyzing bystander effects induced by heavy-ion irradiation between normal and cancer cells  [Not invited]
    Ikeda H; Funayama T; Yokota Y; Kanai T; Kobayashi Y
    The 11th International Workshop on Microbeam Probes of Cellular Radiation Response  2013/10
  • Exploration of the site responsible for the radiation response of the salt chemotaxis learning in C. elegans using heavy-ion microbeam  [Not invited]
    Sakashita T; Suzuki M; Mutou Y; Hattori Y; Ikeda H; Yokota Y; Funayama T; Hamada N; Fukamoto K; Kobayashi Y
    Heavy Ion in Therapy and Space Radiation Symposium 2013  2013/05
  • Cellular response for low-fluence irradiation with HZE-ion beams  [Not invited]
    Suzuki M; Autsavapromporn N; Funayama T; Plante I; Yokota Y; Mutou Y; Suzuki M; Ikeda H; Hattori Y; Kobayashi Y; Murakami T
    3rd Asian Congress of Radiation Research (ACRR2013)  2013/05
  • Current status of heavy-ion microbeam systems of JAEA-Takasaki  [Not invited]
    Funayama T; Yokota Y; Sakashita T; Suzuki M; Ikeda H; Hattori Y; Kobayashi Y
    3rd Asian Congress of Radiation Research (ACRR2013)  2013/05
  • Radiation-quality dependent bystander effects induced by the microbeams with different radiation sources  [Not invited]
    Suzuki M; Autsavapromporn N; Usami N; Funayama T; Plante I; Yokota Y; Mutou Y; Suzuki M; Ikeda H; Hattori Y; Kobayashi K; Kobayashi Y; Murakami T
    Heavy Ion in Therapy and Space Radiation Symposium 2013  2013/05
  • 同細胞種間および異細胞種間における放射線誘発バイスタンダー効果の網羅的検出  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 金井達明; 小林泰彦
    日本原子力学会・学生連絡会主催 学生ポスターセッション  2013/03
  • 線虫の全身運動及び咽頭ポンピング運動に対する放射線影響の照射部位依存性  [Not invited]
    鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    第3回国際放射線神経生物学会  2013/01
  • マイクロビームを用いた線虫の化学走性学習に及ぼす放射線影響部位の探索  [Not invited]
    坂下哲哉; 鈴木芳代; 服部佑哉; 池田裕子; 武藤泰子; 横田裕一郎; 舟山知夫; 浜田信行; 深本花菜; 小林泰彦
    第3回国際放射線神経生物学会  2013/01
  • 重粒子線誘発バイスタンダー効果における細胞種依存性の評価  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 金井達明; 小林泰彦
    第6回日本保健物理学会学生発表会  2012/12
  • 放射線誘発バイスタンダー効果の網羅的検出 ―もたらされる影響は有害か、有益か？―  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 金井達明; 小林泰彦
    日本原子力学会 関東・甲越支部 第11回若手研究者発表討論会  2012/11
  • p53遺伝子欠損メダカ精巣へのマイクロビーム照射影響  [Not invited]
    保田隆子; 尾田正二; 三谷啓志; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子
    第7回高崎量子応用研究シンポジウム  2012/10
  • 重イオン照射肺がん細胞の免疫応答に関する研究  [Not invited]
    武藤泰子; 舟山知夫; 横田裕一郎; 坂下哲哉; 鈴木芳代; 小林泰彦; 池田裕子
    第7回高崎量子応用研究シンポジウム  2012/10
  • 線虫の全身運動に対する重イオンマイクロビーム局部照射の影響  [Not invited]
    鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    第7回高崎量子応用研究シンポジウム  2012/10
  • マイクロビームを用いた線虫の化学走性学習に及ぼす放射線影響部位の探索  [Not invited]
    坂下哲哉; 鈴木芳代; 服部佑哉; 池田裕子; 武藤泰子; 横田裕一郎; 舟山知夫; 小林泰彦; 浜田信行; 深本花菜
    第7回高崎量子応用研究シンポジウム  2012/10
  • 異細胞種間および同細胞種間における重粒子線誘発バイスタンダー応答の経時変化  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 武藤泰子; 小林泰彦; 金井達明
    第7回高崎量子応用研究シンポジウム  2012/10
  • 線質の違いがバイスタンダー効果に及ぼす影響  [Not invited]
    鈴木雅雄; Autsavapromporn; Narongchai; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 鈴木芳代; 服部佑哉; 小林泰彦
    第7回高崎量子応用研究シンポジウム  2012/10
  • マイクロビームを用いた線虫の化学走性学習に及ぼす放射線影響部位  [Not invited]
    坂下哲哉; 鈴木芳代; 服部佑哉; 池田裕子; 武藤泰子; 横田裕一郎; 舟山知夫; 浜田信行; 深本花菜; 小林泰彦
    日本放射線影響学会第55回大会  2012/09
  • メダカ胚の脳に対する重粒子炭素線マイクロビーム照射応答解析  [Not invited]
    保田隆子; 日比勇祐; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦; 尾田正二; 三谷啓志
    日本放射線影響学会第55回大会  2012/09
  • 放射線のエネルギー付与の微視的空間分布における不均一性とマイクロビーム  [Not invited]
    舟山知夫; 横田裕一郎; 池田裕子; 小林泰彦
    日本放射線影響学会第55回大会  2012/09
  • 線虫の筋運動に対する放射線影響の照射部位依存性  [Not invited]
    鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    日本放射線影響学会第55回大会  2012/09
  • 重イオンマイクロビームを用いた異細胞種間バイスタンダー効果解析のための実験系構築  [Not invited]
    池田裕子; 舟山知夫; 横田裕一郎; 金井達明; 小林泰彦
    日本放射線影響学会第55回大会  2012/09
  • 共培養実験系を用いた放射線誘発バイスタンダー効果の網羅的検出  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 武藤泰子; 金井達明; 小林泰彦
    京都大学原子炉実験所専門研究会  2012/08
  • メダカ胚の脳に対する重粒子線マイクロビーム照射応答解析  [Not invited]
    保田隆子; 尾田正二; 日比勇祐; 漆原祐介; 三谷啓志; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    第49回アイソトープ・放射線研究発表会  2012/07
  • Intercellular communication in the propagation of bystander effect in human fibroblasts induced by microbeams: the impact of radiation quality  [Not invited]
    Autsavapromporn N; Suzuki M; Funayama T; Usami N; Yokota Y; Mutou Y; Ikeda H; Itsuka T; Konishi T; Oikawa M; Matsufuji N; Uchihori Y; Kobayashi K; Kobayashi Y; Hei TK; Azzam EI; Murakami T
    10th International Workshop Microbeam Probes of Cellular Radiation Response  2012/03
  • 線虫の全身運動に対する重イオンマイクロビーム照射の影響  [Not invited]
    池田 裕子鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    第2回国際放射線神経生物学会大会  2011/12
  • 放射線誘発異細胞種間バイスタンダー効果の解析  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 武藤泰子; 金井達明; 小林泰彦
    第5回日本保健物理学会学生発表会  2011/12
  • 放射線誘発バイスタンダー応答の時間依存性の解析  [Not invited]
    横田裕一郎; 舟山知夫; 武藤泰子; 池田裕子; 小林泰彦
    日本放射線影響学会第54回大会  2011/11
  • 重粒子線マイクロビーム誘発バイスタンダー効果が生体免疫能に与える影響  [Not invited]
    武藤泰子; 舟山知夫; 横田裕一郎; 池田裕子; 小林泰彦
    日本放射線影響学会第54回大会  2011/11
  • 低LETおよび高LET放射線マイクロビーム照射で誘発されるバイスタンダー効果への細胞間情報伝達機構の関与  [Not invited]
    アッサバプロンポーン; ナロンチャイ; 宇佐美徳子; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 内堀幸夫; 劉翠華; 小林克己; 小林泰彦; ヘイ トム; アザム エドアー; 鈴木雅雄
    日本放射線影響学会第54回大会  2011/11
  • 原子力機構高崎の重イオンマイクロビーム照射装置を用いた生物機能解析研究  [Not invited]
    小林泰彦; 舟山知夫; 田口光正; 田中淳; 和田成一; 渡辺宏; 古澤佳也; 木口憲爾; 深本花菜; 坂下哲哉; 柿崎竹彦; 横田裕一郎; 浜田信行; 鈴木芳代; 武藤泰子; 菊池正博; 服部佑哉; 池田裕子
    日本放射線影響学会第54回大会  2011/11
  • 炭素線誘発異種細胞間バイスタンダー効果の解析  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 武藤泰子; 金井達明; 小林泰彦
    日本放射線影響学会第54回大会  2011/11
  • ブロードビーム全体照射とマイクロビーム局所照射による放射線誘発バイスタンダー応答の誘導時間の違い  [Not invited]
    横田裕一郎; 舟山知夫; 武藤泰子; 小林泰彦; 池田裕子
    第6回高崎量子応用研究シンポジウム  2011/10
  • メダカ個体を用いた重粒子線照射に対する組織応答の解析  [Not invited]
    保田隆子; 尾田正二; 日比勇祐; 漆原祐介; 三谷啓志; 横田裕一郎; 武藤泰子; 池田裕子; 舟山知夫; 小林泰彦
    第6回高崎量子応用研究シンポジウム  2011/10
  • 重粒子線誘発バイスタンダー効果が生体免疫能に与える影響  [Not invited]
    武藤泰子; 舟山知夫; 横田裕一郎; 坂下哲哉; 鈴木芳代; 小林泰彦; 池田裕子
    第6回高崎量子応用研究シンポジウム  2011/10
  • 線虫の運動に対する全身および局部重イオン照射の影響  [Not invited]
    鈴木芳代; 服部佑哉; 坂下哲哉; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    第6回高崎量子応用研究シンポジウム  2011/10
  • ヒト正常細胞の遺伝子突然変異に対するバイスタンダー効果のイオン種依存性  [Not invited]
    鈴木雅雄; 劉翠華、Autsavapromporn; Narongchai; 舟山知夫; 横田裕一郎; 武藤泰子; 池田裕子; 小林泰彦
    第6回高崎量子応用研究シンポジウム  2011/10
  • 異種細胞間における放射線誘発バイスタンダー効果の解析  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 武藤泰子; 小林泰彦; 金井達明
    第6回高崎量子応用研究シンポジウム  2011/10
  • 炭素線誘発バイスタンダー応答における時間依存性の解析  [Not invited]
    横田裕一郎; 舟山知夫; 武藤泰子; 池田裕子; 小林泰彦
    京都大学原子炉実験所専門研究会  2011/07
  • 炭素線誘発異種細胞間バイスタンダー効果の機構解析  [Not invited]
    池田裕子; 横田裕一郎; 舟山知夫; 武藤泰子; 金井達明; 小林泰彦
    京都大学原子炉実験所専門研究会  2011/07

MISC

  • 高橋 昭久; 池田 裕子; 吉田 由香里  生体の科学  69-  (2)  152  -156  2018  [Invited]
  • Analysis of Gamma-ray Induced Bystander Effect between Human Lung Normal and Cancer Cells
    Ikeda H; Yokota Y; Funayama T; Takahashi A; Kanai T; Nakano T; Kobayashi Y  QST Takasaki Annual Report 2015  111  2016
  • 放射線の効果を細胞から細胞へ伝えるバイスタンダー効果の特徴－鍵を握るのは一酸化窒素－
    横田裕一郎; 舟山知夫; 池田裕子; 小林泰彦  Isotope News  741-  21  -25  2016  [Invited]

Awards & Honors

  • 2017/09 Japanese Society for Biological Sciences in Space Young Investigator Award
     
    受賞者: IKEDA Hiroko
  • 2012/11 Atomic Energy Society of Japan, Kanto-Koetsu Branch (11th Young Researcher’s Presentation and Discussion Meeting) Award for Emerging Technology
     
    受賞者: IKEDA Hiroko

Research Grants & Projects

  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2021/04 -2024/03 
    Author : 辻内 俊文; 池田 裕子
     
    Gタンパク共役型受容体であるリゾフォスファチジン酸（LPA：lysophosphatidic acid）受容体は、生理活性脂質であるLPAと結合し、細胞増殖・分化・運動・形態形成など様々な細胞応答を呈する。現在までに6種類（LPA1-LPA6）の受容体が同定され、それぞれの受容体は細胞特異的に異なる作用を有することが判明している。がん細胞においても、LPA受容体を介する細胞内シグナルが、がんの発生・増殖・進展に重要な役割を担うことが明らかとなってきている。本研究は、これまでの知見を基盤に、がん細胞の抗がん剤・放射線感受性制御におけるLPA受容体シグナルの分子機構を明らかにするものである。 研究初年度は、種々のがん細胞を用いて抗がん剤処理と放射線照射を行う2つの実験系に大別して研究を行った。 ①抗がん剤処理によるがん細胞の細胞生存率に対するLPA受容体の機能解析 LPA受容体ノックダウン細胞およびLPA受容体agonist・antagonistを用いて、抗がん剤に対するがん細胞の細胞生存率を解析した。シスプラチン（CDDP）処理膵がん細胞では、LPA2を介する細胞内シグナルの活性化が抗がん剤に対する細胞生存率を上昇させた。一方、大腸がん細胞にフルオロウラシル（5-FU）を処理するとLPA4およびLPA6を介する細胞内シグナルが細胞生存率を低下させることがわかった。 ②放射線照射に対するがん細胞のLPA受容体発現レベルの解析 膵がん・肺がん細胞、骨肉腫・線維肉腫細胞に放射線照射（０～15 Gy）を行い、リアルタイムRT-PCR法を用いて遺伝子発現レベルを測定したところ、細胞特異的にLPA受容体遺伝子発現が誘導されることが示された。また、放射線照射に対する細胞生存率は、LPA2を介する細胞内シグナルにより上昇した。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
    Date (from‐to) : 2020/04 -2022/03 
    Author : Ikeda Hiroko
     
    “Bystander effects” are caused by radiation influences through intercellular communication to nearby non-irradiated cells, and may cause a decrease in the therapeutic effect on radiation-resistant tumors. This study focused on "DNA damage/repair response linked to the cell cycle" to obtain basic knowledge about radiation-resistant cancer cells such as chondrosarcoma and osteosarcoma. By narrowing down the causal pathway and the involvement of intercellular signals, this study aimed to clarify the resistance mechanism of radiation-induced bystander effects.
  • 細胞周期分布と修復動態に着目した放射線誘発バイスタンダー効果の解析
    群馬大学：平成29年度女性研究者研究助成
    Date (from‐to) : 2017 -2018/03 
    Author : 池田裕子

Teaching Experience

  • BiologyBiology Kindai University
  • Biochemistry in MetabolismBiochemistry in Metabolism Kindai University

Social Contribution

  • 「きいて納得！重粒子線がん治療（生物学編）」
    Date (from-to) : 2014/11
    Role : Others
    Category : Open college
    Sponser, Organizer, Publisher  : 群馬大学
    Event, Program, Title : 重粒子線がん治療施設見学会 公開市民講座「最先端がん治療装置のしくみ」

Others

  • 2021/04 -2022/03  放射線抵抗性がん細胞株の新規樹立と細胞応答メカニズムの解明 
    近畿大学学内研究助成金 奨励研究助成金 SR11 研究概要：放射線がん治療の二次がん発生において、放射線抵抗性の獲得の関与が懸念されているが、その詳細は分かっていない。治療効果を高めるためには、細胞機能に関する情報の構築が必須となる。 本研究の目的は、低線量放射線による長期分割照射で「放射線抵抗性の新規細胞株を樹立」し、細胞レベル・分子レベルの解析により「運動能（遊走）、DNA損傷・修復および増殖能（代謝）」に着目して放射線感受性の評価と原因経路を同定することである。本研究の実現により、これまでのX線治療では限界のあった腫瘍に対しても、より効果的な治療アプローチを提案できる可能性があり、得られた生物学的根拠を医学応用へ発展させることが期待できる。
  • 2018/01 -2018/01  Ikeda H. Support of dispatching young researchers abroad from “Living in Space”, 5 years’ fund of “Grant-in-Aid for scientific Research on Innovative Area (2015-2019) from Ministry of Education, Culture, Sports, Science and Technology Japan (MEXT), Texas, USA, January 15-31, 2018.
  • 2015/05 -2015/05  Ikeda H. Support project of research for thesis in Fiscal Year 2014: Financial support for participating in “2015 Radiation Epidemiology and Dosimetry Course (May 18-22, 2015)” at the National Cancer Institute, Rockville, MD, USA, May 2015.
  • 2015/05 -2015/05  Ikeda H, Financial Support for Students and Postdoctoral Fellows of the IWM2015, The 12th International Workshop on Microbeam Probes of Cellular Radiation Response, May30-June1 2015
  • 2014/11 -2014/11  Ikeda H. Support project of research for thesis in Fiscal Year 2014: Supporting for PhD student, November 2014- September 2015.

Other link

researchmap


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.