KINDAI UNIVERSITY


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IKEDA Hiroko

Profile

FacultyDepartment of Life Science
PositionAssistant Professor
DegreePh.D. in Medicine
Commentator Guidehttps://www.kindai.ac.jp/meikan/2459-ikeda-hiroko.html
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Last Updated :2020/06/01

Education and Career

Education

  •   2006 04  - 2010 03 , Kindai University, Faculty of Science and Engineering
  •   2010 04  - 2012 03 , Gunma University Graduate School of Medicine
  •   2012 04  - 2017 03 , Gunma University Graduate School of Medicine

Academic & Professional Experience

  •   2020 04 ,  - 現在, Assistant professor, Faculty of Science and Engineering, Department of Life Science, Kindai University
  •   2017 04 ,  - 2020 03 , Postdoctoral researcher, International Open Laboratory (Dr. Held lab, Harvard Medical School / MGH), Gunma University Initiative for Advanced Research

Research Activities

Research Areas

  • Environmental science/Agricultural science, Environmental effects of radiation
  • Life sciences, Radiology

Research Interests

  • Bystander effect, Radiation biology, Cell biology

Published Papers

  • Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation., Hada M, Ikeda H, Rhone JR, Beitman AJ, Plante I, Souda H, Yoshida Y, Held KD, Fujiwara K, Saganti PB, Takahashi A, Int. J. Mol. Sci., Int. J. Mol. Sci., 20(1), 43, 2019 , Refereed
  • Expression Profile of Cell Cycle-Related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity, Ikeda H, Muratani M, Hidema J, Hada M, Fujiwara K, Souda H, Yoshida Y, Takahashi A, Int. J. Mol. Sci., Int. J. Mol. Sci., 20(19), 4791, 2019 , Refereed
  • Performance evaluation of new devices to synchronize heavy-ion or X-ray irradiation and simulated microgravity for space radiation research ~ Improvement of a control stage ~., Takahashi A, Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, The 31st International Symposium on Space Technology and Science (ISTS), proceeding (Theses ID: 2017-p-09), The 31st International Symposium on Space Technology and Science (ISTS), proceeding (Theses ID: 2017-p-09), 2018 , Refereed
  • Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system., Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A, Life Sci. Space Res., Life Sci. Space Res., 12, 51 - 60, 2017 , Refereed
  • A new system for three-dimensional clinostat synchronized X-irradiation with a high-speed shutter for space radiation research., Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A, Biol. Sci. Space, Biol. Sci. Space, 30, 8 - 16, 2016 , Refereed
  • The bystander cell-killing effect mediated by nitric oxide in normal human fibroblasts varies with irradiation dose but not with radiation quality., Yokota Y, Funayama T, Mutou-Yoshihara Y, Ikeda H, Kobayashi Y, Int. J. Radiat. Biol., Int. J. Radiat. Biol., 91, 383 - 388, 2015 , Refereed
  • Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: the impact of radiation quality., Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou Y, Ikeda H, Kobayashi K, Kobayashi Y, Uchihori Y, Hei TK, Azzam EI, Murakami T, Radiat. Res., Radiat. Res., 180, 367 - 375, 2013 , Refereed
  • No mutations of lysophosphatidic acid receptor genes in lung adenocarcinomas induced by N-Nitrosobis(2-hydroxypropyl)amine in rats, Naoko Wakabayashi, Megumu Tsujino, Masaki Tajiri, Midori Taki, Ayumi Koshino, Hiroko Ikeda, Nobuyuki Fukushima, Toshifumi Tsujiuchi, Journal of Toxicologic Pathology, Journal of Toxicologic Pathology, 23(1), 63 - 66, Apr. 2010 , Refereed
    Summary:Lysophosphatidic acid (LPA) is a bioactive phospholipid that stimulates cell proliferation and migration, and protects cells from apoptosis. It interacts with specific G protein-coupled transmembrane receptors. Recently, frequent mutations of the LPA receptor-1 (LPA1) gene were detected in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). In this study, to evaluate the involvement of other LPA receptor gene alterations during lung carcinogenesis, we investigated mutations of the LPA2, LPA3, LPA4 and LPA5 genes in lung adenocarcinomas induced by BHP in rats. Fifteen male Wistar rats, 6 weeks of age, were given 2000 ppm BHP in their drinking water for 12 weeks and then maintained without further treatment until sacrifice at 25 weeks, and 15 adenocarcinomas were obtained. Genomic DNAs were extracted from frozen tissues, and the LPA2, LPA3, LPA4 and LPA5 genes were examined for mutations, using polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) analysis. No mutations of LPA2, LPA3, LPA4 and LPA5 were detected in the 15 adenocarcinomas. These results suggest that alterations due to LPA2, LPA3, LPA4 and LPA5 gene mutations might not be involved in the development of lung adenocarcinomas induced by BHP in rats.

Conference Activities & Talks

  • The synergistic effect of simulated microgravity and charged particle radiation on gene expression in human fibroblasts, Ikeda H, Muratani M, Puspitasari A, Held KD, Kawamura H, Hidema J, Yoshida Y, Takahashi A, COSPAR2018, 42th ASSEMBLY,   2018 07
  • Comprehensive gene expression analysis of human fibroblasts using new device to synchronize carbon-ion irradiation and simulated microgravity, Ikeda H, Prairie View A&M University (CRI/RaISE Science seminar),   2018 01 , 招待有り
  • Development of 3D clinostat synchronized irradiation systems for simulating space conditions, Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Hada M, Saganti P, Yoshida Y, Kanai T, Takahashi A, 2018 NASA Human Research Program Investigators’ Workshop,   2018 01
  • Importance of the combined effects of radiation and simulated microgravity for space biosciences, Ikeda H, Puspitasari A, Held KD, Yoshida Y, Takahashi A, 21st IAA Humans in Space Symposium,   2017 11
  • RNAseq profiling to analyze the combined effects on radiation under simulated microgravity for space biosciences, Takahashi A, Ikeda H, Muratani M, Puspitasari A, Held KD, Hidema J, Yoshida Y, 63rd Annual RRS Meeting,   2017 10
  • Performance evaluation of new devices to synchronize X-ray or heavy-ion irradiation and simulated microgravity for space radiation research, Takahashi A, Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, The 31st International Symposium on Space Technology and Science,   2017 06
  • New devices to synchronize irradiation and simulated µG for space radiation research, Takahashi A, Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, The 5th International Symposium on Space Radiation and Particle Radiotherapy, including the 8th International Workshop on Space Research Radiation (IWSRR) and the 17th Ion Beams in Biology and Medicine (IBIBAM),   2017 05
  • Gene expression profile changes of human fibroblasts using device to synchronize carbon-ion irradiation and simulated microgravity, Ikeda H, Muratani M, Puspitasari A, Held KD, Hidema J, Yoshida Y, Takahashi A, The 5th International Symposium on Space Radiation and Particle Radiotherapy, including the 8th International Workshop on Space Research Radiation (IWSRR) and the 17th Ion Beams in Biology and Medicine (IBIBAM),   2017 05
  • Comprehensive gene expression analysis of human fibroblasts after combined exposure to microgravity and heavy-ions for simulating space conditions, Ikeda H, Muratani M, Puspitasari A, Held KD, Hidema J, Yoshida Y, Takahashi A, The 7th International Society of Radiation Neurobiology Conference,   2017 02
  • Effects of oxygen concentration and radiation quality on radiation-induced DNA damage, Tominaga S, Okada H, Ikeda H, Yoshida Y, Takahashi A, The 7th International Society of Radiation Neurobiology Conference,   2017 02
  • Development of new devices that analyze the combined effects of radiation and microgravity: 2nd report, Takahashi A, Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, The 7th International Society of Radiation Neurobiology Conference,   2017 02
  • Development of 3D-clinostat synchronized heavy-ion irradiation system, Ikeda H, Hidema J, Nikawa T, Yoshida Y, Souda H, Kanai T, Takahashi A, 11th Asian Microgravity Symposium,   2016 10
  • Evaluation of survival curves for solid tumor cells after large doses of carbon ion beams and X-rays, Yoshida Y, Ando K, Koike S, Yako T, Ikeda H, Uzawa A, Matsumoto T, Isono M, Kanai T, Nakano T, 15th International Congress of Radiation Research,   2015 05
  • Bystander cell-killing effect mediated by nitric oxide in nor mal human fibroblasts depends on irradiation dose but not on radiation quality, Yokota Y, Funayama T, Ikeda H, Mutoh Yoshihara Y, Suzuki M, Sakashita T, Kobayashi Y, 15th International Congress of Radiation Research,   2015 05
  • P53-dependent cell-killing effect via bystander effect using carbon-ion microbeams simulating the spot scanning system with pencil beams at HIMAC, Suzuki M, Funayama T, Yokota Y, Suzuki M, Ikeda H, Sakashita T, Kobayashi Y, Murakami T, 15th International Congress of Radiation Research,   2015 05
  • Target irradiation of cells and individuals with heavy-ion microbeams of JAEA-Takasaki, Funayama T, Yokota Y, Sakashita T, Suzuki M, Ikeda H, Kobayashi Y, 15th International Congress of Radiation Research,   2015 05
  • Radiation quality-independent bystander effect and its molecular mechanism, Yokota Y, Funayama T, Ikeda H, Mutoh-Yoshihara Y, Suzuki M, Sakashita T, Kobayashi Y, The 12th International Workshop on Microbeam Probes of Cellular Radiation Response,   2015 05
  • Responses of the salt chemotaxis learning in wild type and mutant C. elegans to microbeam irradiation, Sakashita T, Suzuki M, Hattori Y, Ikeda H, Mutou Y, Yokota Y, Funayama T, Hamada N, Shirai K, Kobayashi Y, 15th International Congress of Radiation Research,   2015 05
  • The systemic effects of irradiation revealed by the local irradiation to the medaka testis using carbon-ion micro-beam system in TIARA, Oda S, Yasuda T, Watanabe-Asaka T, Ikeda H, Muto Y, Yokota Y, Sakashita T, Suzuki M, Funayama T, Kobayashi Y, Mitani H, The 12th International Workshop on Microbeam Probes of Cellular Radiation Response,   2015 05
  • Analysis of medium-mediated bystander effects induced by carbon-ion irradiation between human lung normal and cancer cells, Ikeda H, Yokota Y, Funayama T, Kanai T, Nakano T, Kobayashi Y, 15th International Congress of Radiation Research,   2015 05
  • Patterning irradiation for contact co-culture of different type cells using heavy-ion microbeam, Ikeda H, Yokota Y, Funayama T, Kanai T, Nakano T, Kobayashi Y, The 12th International Workshop on Microbeam Probes of Cellular Radiation Response,   2015 05
  • Responses of the salt chemotaxis learning in wild type and mutant C. elegans to microbeam irradiation, Sakashita T, Suzuki M, Hattori Y, Ikeda H, Mutou Y, Yokota Y, Funayama T, Hamada N, Shirai K, Kobayashi Y, The 5th International Society of Radiation Neurobiology Conference,   2015 02
  • Bystander cell-killing effect mediated by nitric oxide in normal human fibroblasts depends in part on irradiation dose but not on radiation quality, Yokota Y, Funayama T, Ikeda H, Kobayashi Y, The 60th Annual Meeting of the Radiation Research Society,   2014 09
  • Effects of carbon-ion microbeam irradiation on locomotion and pharyngeal pumping in C. elegans, Suzuki M, Hattori Y, Sakashita T, Funayama T, Yokota Y, Ikeda H, Kobayashi Y, 11th International Workshop on Microbeam Probes of Cellular Radiation Response,   2013 10
  • Analysis of bystander effects induced by heavy ions and gamma-rays, Yokota Y, Funayama T, Ikeda H, Mutoh-Yoshihara Y, Suzuki M, Sakashita T, Kobayashi Y, 11th International Workshop on Microbeam Probes of Cellular Radiation Response,   2013 10
  • Recent progress in development of heavy-ion microbeam systems of JAEA-Takasaki, Funayama T, Yokota Y, Suzuki M, Ikeda H, Sakashita T, Kobayashi Y, 11th International Workshop on Microbeam Probes of Cellular Radiation Response,   2013 10
  • Establishment of experimental systems for analyzing bystander effects induced by heavy-ion irradiation between normal and cancer cells, Ikeda H, Funayama T, Yokota Y, Kanai T, Kobayashi Y, The 11th International Workshop on Microbeam Probes of Cellular Radiation Response,   2013 10
  • Exploration of the site responsible for the radiation response of the salt chemotaxis learning in C. elegans using heavy-ion microbeam, Sakashita T, Suzuki M, Mutou Y, Hattori Y, Ikeda H, Yokota Y, Funayama T, Hamada N, Fukamoto K, Kobayashi Y, Heavy Ion in Therapy and Space Radiation Symposium 2013,   2013 05
  • Cellular response for low-fluence irradiation with HZE-ion beams, Suzuki M, Autsavapromporn N, Funayama T, Plante I, Yokota Y, Mutou Y, Suzuki M, Ikeda H, Hattori Y, Kobayashi Y, Murakami T, 3rd Asian Congress of Radiation Research (ACRR2013),   2013 05
  • Current status of heavy-ion microbeam systems of JAEA-Takasaki, Funayama T, Yokota Y, Sakashita T, Suzuki M, Ikeda H, Hattori Y, Kobayashi Y, 3rd Asian Congress of Radiation Research (ACRR2013),   2013 05
  • Radiation-quality dependent bystander effects induced by the microbeams with different radiation sources, Suzuki M, Autsavapromporn N, Usami N, Funayama T, Plante I, Yokota Y, Mutou Y, Suzuki M, Ikeda H, Hattori Y, Kobayashi K, Kobayashi Y, Murakami T, Heavy Ion in Therapy and Space Radiation Symposium 2013,   2013 05
  • Intercellular communication in the propagation of bystander effect in human fibroblasts induced by microbeams: the impact of radiation quality, Autsavapromporn N, Suzuki M, Funayama T, Usami N, Yokota Y, Mutou Y, Ikeda H, Itsuka T, Konishi T, Oikawa M, Matsufuji N, Uchihori Y, Kobayashi K, Kobayashi Y, Hei TK, Azzam EI, Murakami T, 10th International Workshop Microbeam Probes of Cellular Radiation Response,   2012 03

Misc

  • Role of High-Linear Energy Transfer Radiobiology in Space Radiation Exposure Risks., Takahashi A, Ikeda H, Yoshida Y, Int J Particle Ther., 5, 1, 151, 159,   2018 , Refereed
  • Analysis of Gamma-ray Induced Bystander Effect between Human Lung Normal and Cancer Cells, Ikeda H, Yokota Y, Funayama T, Takahashi A, Kanai T, Nakano T, Kobayashi Y, QST Takasaki Annual Report 2015, 111,   2016

Awards & Honors

  •   2017 09 , Japanese Society for Biological Sciences in Space, Young Investigator Award
  •   2012 11 , Atomic Energy Society of Japan, Kanto-Koetsu Branch (11th Young Researcher’s Presentation and Discussion Meeting), Award for Emerging Technology

Others

  •   2018 01 , Ikeda H. Support of dispatching young researchers abroad from “Living in Space”, 5 years’ fund of “Grant-in-Aid for scientific Research on Innovative Area (2015-2019) from Ministry of Education, Culture, Sports, Science and Technology Japan (MEXT), Texas, USA, January 15-31, 2018.
  •   2015 05 , Ikeda H. Support project of research for thesis in Fiscal Year 2014: Financial support for participating in “2015 Radiation Epidemiology and Dosimetry Course (May 18-22, 2015)” at the National Cancer Institute, Rockville, MD, USA, May 2015.
  •   2015 05 , Ikeda H, Financial Support for Students and Postdoctoral Fellows of the IWM2015, The 12th International Workshop on Microbeam Probes of Cellular Radiation Response, May30-June1 2015
  •   2014 11 , Ikeda H. Support project of research for thesis in Fiscal Year 2014: Supporting for PhD student, November 2014- September 2015.