詳細

稲田　莉乃 （イナダ　リノ）

  • 医学科　医学部講師
Last Updated :2024/04/25

コミュニケーション情報 byコメンテータガイド

  • コメント

    脳神経内科一般の基本的な疾患・治療法の説明

研究者情報

学位

  • 博士（医学）

ホームページURL

J-Global ID

プロフィール

  • 日本内科学会認定内科医・総合内科専門医


    日本神経学会神経内科専門医

現在の研究分野（キーワード）

    脳神経内科一般の基本的な疾患・治療法の説明

研究分野

  • その他 / その他

研究活動情報

論文

  • Atsushi Terayama; Keisuke Yoshikawa; Toru Michiura; Kanako Fujii; Rino Inada; Yoshiyuki Mitsui; Ichizo Nishino; Yoshitaka Nagai
    Clinical neurology and neurosurgery 229 107715 - 107715 2023年04月 
    Patients with myasthenia gravis (MG) often have other autoimmune disorders. However, the coexistence of MG and myositis is rare. Here, we report a case of a 77-year-old woman who developed mild fatigable muscle weakness and diplopia in 3 months. Serum creatine kinase was elevated to 1385 IU/L. Antibodies to acetylcholine receptor (AChR), titin and voltage-gated potassium channel 1.4 (Kv 1.4) were all positive while all tested myositis-specific autoantibodies were negative. Standard needle electromyography showed fibrillation potential and early recruitment of motor units. The repetitive nerve stimulations were consistent with a disorder of the neuromuscular junction. Muscle biopsy showed that the clusters of histiocyte were present along the fascicles in perimysium and some of them invaded into endomysium.
  • 内眼筋麻痺を主徴とした不全型Fisher症候群の一例
    寺山 敦之; 定金 秀爾; 稲田 莉乃; 大賀 智行; 三井 良之; 楠 進
    臨床神経学 62 1 69 - 69 (一社)日本神経学会 2022年01月
  • Kanako Fujii; Makito Hirano; Atsushi Terayama; Rino Inada; Yoshihiko Saito; Ichizo Nishino; Yoshitaka Nagai
    Neuromuscular Disorders 2022年01月
  • 外眼筋麻痺を伴わず両側内眼筋麻痺を主徴とした不全型Fisher症候群の2例
    寺山 敦之; 吉川 恵輔; 定金 秀爾; 稲田 莉乃; 桑原 基; 宮本 勝一; 大賀 智行; 永井 義隆
    神経免疫学 26 1 156 - 156 (一社)日本神経免疫学会 2021年10月
  • Rino Inada; Makito Hirano; Nobuyuki Oka; Makoto Samukawa; Kazumasa Saigoh; Hidekazu Suzuki; Fukashi Udaka; Akihiro Hashiguchi; Hiroshi Takashima; Yukihiro Hamada; Yusaku Nakamura; Susumu Kusunoki
    Journal of neurology 268 8 2933 - 2942 2021年08月 
    BACKGROUND: We intended to clarify the phenotypic and molecular diversities of spinocerebellar ataxia type 2 (SCA2) in Japan. METHODS: DNA was extracted from the peripheral blood of 436 patients, including 126 patients with chronic neuropathy, 108 with amyotrophic lateral sclerosis, and 202 with cerebellar ataxia. We then PCR-amplified and sequenced the ATXN2 gene. The biopsied sural nerves of mutation-positive patients were subjected to light-microscopic and electron-microscopic analyses. Transfection analyses were performed using a Schwann cell line, IMS32. RESULTS: We found PCR-amplified products potentially corresponding to expanded CAG repeats in four patients. Two patients in the chronic neuropathy group had a full repeat expansion or an intermediate expansion (39 or 32 repeats), without limb ataxia. The sural nerve biopsy findings of the two patients included axonal neuropathy and mixed neuropathy (axonal changes with demyelination). Schwann cells harbored either cytoplasmic or nuclear inclusions on electron microscopic examination. Both patients recently exhibited pyramidal signs. In the third patient in the cerebellar ataxia group, we identified a novel 21-base duplication mutation near 22 CAG repeats (c.432_452dup). The transfection study revealed that the 21-base-duplication mutant Ataxin-2 proteins aggregated in IMS32 and rendered cells susceptible to oxidative stress, similar to a CAG-expanded mutant. The fourth patient, with 41 repeats, had ataxia and spasticity. The two patients with cerebellar ataxia also had peripheral neuropathy. CONCLUSIONS: Patients with expanded CAG repeats can exhibit a neuropathy-dominant phenotype not described previously. The novel 21-base-duplication mutant seems to share the aggregation properties of polyglutamine-expanded mutants.
  • Rino Inada; Katsuichi Miyamoto; Noriko Tanaka; Kota Moriguchi; Kenji Kadomatsu; Kosei Takeuchi; Michihiro Igarashi; Susumu Kusunoki
    Glycobiology 31 3 260 - 265 2021年04月 
    Proteoglycans (PGs) are one of the main components in the extracellular matrix of the central nervous system. Chondroitin sulfate (CS) is a glycosaminoglycan (GAG), which is composed of major PGs. Similar to keratin sulfate (KS), another GAG, CS inhibits axon regeneration. However, the influence of these GAGs on the pathogenicity of neuroimmunological diseases is unclear. Here, we induced experimental autoimmune encephalomyelitis (EAE) in mice lacking CS N-acetylgalactosaminyltransferase-1 (CSGalNAcT1-KO), an important enzyme for CS synthesis. In our study, CSGalNAcT1-KO mice showed milder EAE symptoms than those in wild-type (WT) mice. The recall response of antigen-specific lymphocytes showed that CSGalNAcT1-KO-derived lymphocytes had a milder cell proliferation response than that in WT-derived lymphocytes. These results suggest that CS contributes toward the induction phase of EAE. We previously performed EAE experiments in GlcNAc-6-O-sulfotransferase KO (GlcNAc6ST-KO) and C6ST1-KO mice, which had reduced KS and reduced CS-C, respectively. EAE in CSGalNAcT1-KO mice was more similar to that in GlcNAc6ST-KO mice than in C6ST1-KO mice. In conclusion, the distinct GAG sugar chains are associated with severe or mild phenotypes of EAE and are therefore potential new therapeutic targets for neuroimmunological diseases, including multiple sclerosis.
  • Rino Inada; Katsuichi Miyamoto; Noriko Tanaka; Kota Moriguchi; Susumu Kusunoki
    Internal medicine (Tokyo, Japan) 59 1 55 - 60 2020年01月 
    Objective Oryeongsan (Goreisan), a formula composed of five herbal medicines, has long been used to treat impairments of the regulation of body fluid homeostasis. Goreisan has been revealed to have anti-inflammatory actions and inhibit a water channel, the aquaporin (AQP). We herein report the therapeutic effect of Goreisan on experimental autoimmune encephalomyelitis (EAE in, an animal model of inflammatory demyelinating diseases. Materials and Methods EAE mice immunized with MOG35-55 peptide were divided into Goreisan- and sham-treated groups. The clinical EAE score and histopathological finding of the central nervous system (CNS) were analyzed. For the proliferation assay, prepared spleen cells from immunized mice were cultured and analyzed for the [3H]-thymidine uptake and cytokine concentrations of the culture supernatant. The relative quantification of AQP4 mRNA in the CNS of EAE mice was analyzed quantitatively. Results The EAE score of the Goreisan-treated mice was significantly lower than that of the sham-treated mice. The CD4-positive cell number in the CNS of Goreisan-treated mice was lower than that of sham-treated mice. In the recall response to MOG35-55 peptide, the cell proliferation did not differ markedly between the spleen cells from Goreisan- and sham-treated mice. Furthermore, Goreisan decreased the mRNA level of AQP4 in the spinal cord during EAE. Conclusion Goreisan prevented the disease activity of EAE by inhibiting the migration of pathogenic cells into the CNS by suppressing the AQP4 expression in the CNS. Goreisan may have a therapeutic effect on inflammatory demyelinating diseases.
  • 脱髄性ニューロパチーにて発症し、神経生検にて診断に至った神経サルコイドーシスの一例
    定金 秀爾; 名村 仁志; 稲田 莉乃; 桑原 基; 西郷 和真; 岡 伸幸; 竹内 啓喜; 楠 進
    臨床神経学 59 12 843 - 843 (一社)日本神経学会 2019年12月
  • 桑原 基; 吉川 恵輔; 森川 みゆき; 稲田 莉乃; 寒川 真; 平野 牧人; 楠 進
    末梢神経 30 2 335 - 335 日本末梢神経学会 2019年12月
  • 難治性てんかん症例におけるペランパネル導入の検討
    西郷 和真; 森口 幸太; 平野 牧人; 山下 翔子; 定金 秀爾; 柳本 諭志; 稲田 莉乃; 岡崎 真央; 寒川 真; 鈴木 秀和; 三井 良之; 楠 進
    臨床神経学 59 Suppl. S365 - S365 (一社)日本神経学会 2019年11月
  • ペランパネルを使用した難治性てんかん8症例の検討
    森口 幸太; 西郷 和真; 山下 翔子; 定金 秀爾; 柳本 諭志; 稲田 莉乃; 岡崎 真央; 寒川 真; 鈴木 秀和; 平野 牧人; 三井 良之; 楠 進
    大阪てんかん研究会雑誌 29 1 7 - 9 大阪てんかん研究会 2018年11月 
    ペランパネル(PER)を投与した難治性てんかん8例(男性4例、女性4例、平均45.5歳)を対象とした。知的能力障害を伴った症例が4例あり、幼少期からてんかん発作を認めた。比較的高齢使用例の2例は、特発性血小板減少性紫斑病や、多発血管炎性肉芽腫症を合併した。抗てんかん薬(AED)は、PERを含めて2～4剤(平均3.1剤)であった。併用AEDとして使用されていたのは、バルプロ酸(VPA)4例、レベチラセタム(LEV)3例、ラモトリギン(LTG)3例、カルバマゼピン(CBZ)3例、ゾニサミド(ZNS)2例、ラコサミド(LCM)1例、ガバペンチン(GBP)1例であった。知的能力障害を伴う2例は焦燥感、興奮性等の症状により投与を中止した。知的能力障害を伴わない成人発症てんかん6例は、比較的少量で有効性を認め、ふらつきで減量を要する症例もあったが、薬剤中止はなく忍容性は良好であった。CBZの併用は3例で、うち1例は最大容量に近い10mgまでPERが増量され、CBZにより血中濃度が低下していた可能性が考えられた。
  • 脳幹脳炎の併発により急性水頭症に至ったリステリア髄膜炎の1例
    定金 秀爾; 山下 翔子; 稲田 莉乃; 寒川 真; 楠 進
    NEUROINFECTION 23 2 204 - 204 日本神経感染症学会 2018年10月
  • Rino Ueno; Katsuichi Miyamoto; Noriko Tanaka; Kota Moriguchi; Kenji Kadomatsu; Susumu Kusunoki
    JOURNAL OF NEUROSCIENCE RESEARCH 93 12 1874 - 1880 2015年12月 [査読有り]
     
    Proteoglycans (PGs) are the components of extracellular matrices in the central nervous system (CNS). Keratan sulfate (KS) is a glycosaminoglycan that is included in the KSPG that acts as an inhibitory factor in nerve regeneration after CNS injury. To investigate the role of KS in immune diseases, we induced experimental autoimmune encephalomyelitis (EAE) in mice that were deficient in the N-acetylglucosamine (GlcNAc)-6-O-sulfotransferase 1 (GlcNAc6ST1) gene (KS-KO). KS-KO mice developed less severe EAE and showed repressed recall response in the induction phase. Furthermore, GlcNAc6ST1 might have roles in the passage of the pathogenic lymphocytes through the blood-brain barrier via adhesion molecules. Thus, modulation of KS may become a treatment for neuroimmunological diseases. (c) 2015 Wiley Periodicals, Inc.
  • C型肝炎ウイルス感染に伴うクリオグロブリン血症に関連した神経障害の検討
    稲田 莉乃; 森川 みゆき; 加藤 茉里; 鈴木 秀和; 萩原 智; 宮本 勝一; 三井 良之; 岡 伸幸; 楠 進
    臨床神経学 54 Suppl. S156 - S156 (一社)日本神経学会 2014年12月

MISC

その他のリンク

researchmap


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.