詳細

川﨑　薫 （カワサキ　カオル）

  • 医学科　医学部講師
Last Updated :2024/04/25

コミュニケーション情報 byコメンテータガイド

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研究者情報

学位

  • 博士（医学）（2019年07月 京都大学）
  • 医学学士（2003年03月 京都大学）

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J-Global ID

研究キーワード

  • メタボローム解析   腸内細菌   硫酸マグネシウム   妊娠高血圧腎症   妊娠高血圧症候群   産婦人科   周産期   

現在の研究分野（キーワード）

    患者さんのお役に立つことができるように臨床、研究、教育に努めて参ります。

研究分野

  • ライフサイエンス / 医療薬学 / 産婦人科 周産期

経歴

  • 2021年03月 - 現在  近畿大学医学部産科婦人科学教室助教
  • 2020年04月 - 2021年03月  京都大学医学部婦人科学産科学教室助教
  • 2019年09月 - 2020年03月  京都大学医学部婦人科学産科学教室特定病院助教
  • 2018年05月 - 2019年08月  神戸市立医療センター 中央市民病院産婦人科医長
  • 2017年04月 - 2018年05月  独立行政法人国立病院機構 京都医療センター産婦人科医員
  • 2012年04月 - 2013年03月  京都大学医学部婦人科学産科学教室特定病院助教
  • 2011年04月 - 2012年03月  国立研究開発法人国立循環器病研究センター周産期婦人科医員
  • 2009年06月 - 2011年03月  独立行政法人国立病院機構 京都医療センター産婦人科医員
  • 2007年03月 - 2009年05月  倉敷中央病院産婦人科医員
  • 2005年03月 - 2007年03月  天理よろづ相談所病院 産婦人科医員
  • 2003年04月 - 2005年02月  京都大学医学部附属病院 産科婦人科研修医

学歴

  • 2013年04月 - 2017年03月   京都大学大学院   医学研究科   婦人科学産科学
  • 1997年04月 - 2003年03月   京都大学   医学部

所属学協会

  • 日本血栓止血学会   日本内視鏡外科学会   日本超音波医学会   日本産婦人科腫瘍学会   日本人類遺伝学会   日本産婦人科内視鏡学会   日本胎児心臓病学会   日本妊娠高血圧学会   日本胎盤学会   日本周産期新生児医学会   日本産婦人科医会   日本産科婦人科学会   

研究活動情報

論文

  • Yu Takaishi; Kaoru Kawasaki; Kazuhiko Uematsu; Shinya Yoshioka
    Journal of Medical Ultrasonics 2024年03月 [査読有り]
  • 「周産期における血液凝固異常症の早期発見に役立つ検査 ～暫定版産科DIC診断基準と妊娠高血圧腎症の発症予測バイオマーカー～」
    川﨑薫
    日本臨床医学検査会誌 71 9 650 - 653 2023年09月
  • Yoshie Yo; Kaoru Kawasaki; Kaori Moriuchi; Reona Shiro; Masao Shimaoka; Noriomi Matsumura
    Healthcare 11 11 1657 - 1657 2023年06月 
    Several studies in Europe and the United States have shown that sexual intercourse (SI) during pregnancy is not associated with preterm birth. However, it is unclear whether these findings apply to pregnant Japanese women. The aim of this prospective cohort study was to elucidate the influence of SI during pregnancy on preterm birth in Japan. A total of 182 women who underwent antenatal care and delivery were included in this study. The frequency of SI was assessed using a questionnaire, and its association with preterm birth was analyzed. The results showed that SI during pregnancy was associated with a significantly higher cumulative preterm birth rate (p = 0.018), which was more pronounced for SI more than once a week (p < 0.0001). Multivariate analysis showed that SI, bacterial vaginosis in the second trimester, previous preterm birth, and smoking during pregnancy were independent risk factors for preterm birth. The combination of SI and second trimester bacterial vaginosis was associated with a 60% preterm birth rate, whereas either factor alone was associated with a lower rate, suggesting a synergistic effect (p < 0.0001). Future studies are needed to investigate the effect of prohibiting SI in pregnant women with bacterial vaginosis on preterm birth.
  • Reona Shiro; Yasushi Kotani; Mamiko Ohta; Hanako Sato; Yoko Kashima; Kosuke Murakami; Kaoru Kawasaki; Hidekatsu Nakai; Noriomi Matsumura
    Healthcare 11 11 1619 - 1619 2023年06月 
    Background: Cervical cystic lesions encompass a range of benign and malignant pathologies. Magnetic resonance imaging or cytology alone cannot provide a definitive diagnosis, and conventional practice involves performing a cervical biopsy by conization to confirm the histology in cases exhibiting potential signs of lobular endocervical glandular hyperplasia (LEGH) or malignancy. However, as postoperative complications resulting from conization can impact future fertility and pregnancy, alternative diagnostic methods are needed for reproductive-age patients. This study aimed to establish the efficacy of a hysteroscopic biopsy for diagnosing cervical cystic lesions and compare it with conization. Methods: Thirteen patients with cervical cystic lesions suspected of LEGH or malignancy underwent a hysteroscopic biopsy, while 23 underwent conization. Patient background information, preoperative evaluation, histology, and postoperative outcomes were collected and compared retrospectively. Results: No significant differences were found between the hysteroscopy and conization groups in terms of mean patient age (45 vs. 48 years), operating time (23 vs. 35 min), blood loss (small amount vs. 43 mL), and postoperative hospitalization (1.1 vs. 1.6 days). Conclusion: A hysteroscopic biopsy allows for targeted resection of the cervix while maintaining diagnostic accuracy. It may serve as an efficient method for diagnosing cervical cystic lesions.
  • 伊田 昂平; 川崎 薫; 森内 芳; 大須賀 拓真; 松坂 優; 滝 真奈; 山口 綾香; 千草 義継; 最上 晴太; 近藤 英治; 万代 昌紀
    産婦人科の進歩 75 1 32 - 38 「産婦人科の進歩」編集室 2023年02月 
    後期早産(妊娠34週0日-36週6日)が予測される妊婦へのステロイド投与は新生児呼吸障害を低下させると報告されているが,本邦における投与指針は確立していない.本研究では,2014年から2015年の間にステロイドを投与されずに後期早産に至った49例(非投与群)と,2016年から2020年の間にステロイド投与後に後期早産に至った31例(投与群)の2群間で比較検討を行った.2群間で新生児一過性多呼吸(transient tachypnea of the newborn;TTN)や新生児呼吸窮迫症候群(respiratory distress syndrome;RDS)の発症やサーファクタント製剤の使用に有意差は認めなかった.分娩週数ごとの比較でもTTN,RDSの発症やサーファクタント製剤の使用に有意差を認めなかった.合併症として新生児低血糖の発症は2群間で有意差を認めなかった.またステロイド投与による母体合併症も認めなかった.今回の単施設後方視的検討では,late Pretermにおける経母体ステロイド投与の効果は示されなかった.今後本邦での多施設共同研究による検討が望まれる.(著者抄録)
  • Risa Fujishima; Kaoru Kawasaki; Kaori Moriuchi; Reona Shiro; Yoshie Yo; Noriomi Matsumura
    Healthcare 11 2 168 - 168 2023年01月 
    This retrospective study aims to compare the early manual removal of placenta (MROP) and conservative management of retained products of conception (RPOC) after 34 weeks of gestation. Nineteen cases underwent MROP within 24 h of delivery, of which nine patients had no symptoms requiring emergent treatment. These 9 patients (group M) were compared with 22 patients who were treated conservatively (group C). Massive bleeding was observed in 5 (56%) patients in group M and 11 (50%) patients in group C, with no significant difference in frequency. However, the lowest hemoglobin level within 72 h after massive bleeding was lower in group M (median: 6.7 vs. 7.7 g/dL, p = 0.029), suggesting that massive bleeding occurred in a short period of time. On the other hand, a retained placenta was observed in four patients in group M after the MROP; however, the placenta disappeared more quickly than in group C (median; 1.0 vs. 99.0 days, p = 0.009). In group C, all bleeding and infection occurred within 60 days of delivery, including heavy bleeding in six cases during the placental-extraction trial. Human chorionic gonadotropin in group C fell below the measurable threshold at a median of 67 days postpartum. In conclusion, for RPOC without urgent symptoms, early MROP and conservative treatment have their advantages and disadvantages. Randomized controlled trials are needed to determine which of those treatments is superior.
  • A case of placental multiple giant chorangioma leading to neonatal death from fetal hydrops
    Aoi Shiraga; Takuma Ohsuga; Kaoru Kawasaki; Haruta Mogami; Sachiko Minamiguchi; Masaki Mandai
    12 2023年
  • Yudai Tateishi; Katsuyuki Sakanaka; Hideaki Hirashima; Nobutaka Mukumoto; Hiroyuki Inoo; Kota Fujii; Tomohiro Ono; Mitsuhiro Nakamura; Manabu Nakata; Kaoru Kawasaki; Hirohiko Tani; Masaki Mandai; Takashi Mizowaki
    International cancer conference journal 11 4 292 - 297 2022年10月 
    The information of definitive radiotherapy for a pregnant woman with malignancy was limited; however, it was reported to be potentially feasible with minimal risks. We performed definitive chemoradiotherapy for a pregnant woman with locally advanced cervical esophageal cancer. Feasibility of radiotherapy and safety of fetus were confirmed by the phantom study estimating fetal dose, and monitoring it in each radiotherapy session. The planned chemoradiotherapy completely eradicated esophageal cancer while preserving her laryngopharyngeal function. A female infant was delivered by cesarian section after planned chemoradiotherapy, and she grew without any apparent disorders 2 years after chemoradiotherapy. Chemoradiotherapy might be one of the treatment options for a pregnant woman with cervical esophageal cancer especially wishing the preservation of laryngopharyngeal function.
  • Yosuke Kawamura; Haruta Mogami; Eriko Yasuda; Masahito Takakura; Yu Matsuzaka; Yusuke Ueda; Asako Inohaya; Kaoru Kawasaki; Yoshitsugu Chigusa; Masaki Mandai; Eiji Kondoh
    Science signaling 15 751 eabi5453  2022年09月 
    The premature rupture of the amniotic sac, a condition referred to as a preterm prelabor rupture of membranes (pPROM), is a leading cause of preterm birth. In some cases, these ruptured membranes heal spontaneously. Here, we investigated repair mechanisms of the amnion, a layer of epithelial cells in the amniotic sac closest to the embryo. Macrophages migrated to and resided at rupture sites in both human and mouse amnion. A process called epithelial-mesenchymal transition (EMT), in which epithelial cells acquire a mesenchymal phenotype and which is implicated in tissue repair, was observed at rupture sites. In dams bearing macrophage-depleted fetuses, the repair of amnion ruptures was compromised, and EMT was rarely detected at rupture sites. The migration of cultured amnion epithelial cells in wound healing assays was mediated by EMT through transforming growth factor-β (TGF-β)-Smad signaling. These findings suggest that fetal macrophages are crucial in amnion repair because of their ability to induce EMT in amnion epithelial cells.
  • Kaori Moriuchi; Kaoru Kawasaki; Maako Hayashi; Akihiko Ueda; Yukio Yamanishi; Haruta Mogami; Kohei Fujita; Reona Shiro; Yoshie Yo; Masaki Mandai; Noriomi Matsumura
    Healthcare 10 8 1581 - 1581 2022年08月 
    In preeclampsia, plasma antithrombin activity is decreased, which leads to exacerbation of the disorder. We previously showed that long-term magnesium sulfate (MgSO4) administration prolonged the pregnancy period and may be able to improve pregnancy outcomes for patients with severe preeclampsia. The present study aimed to investigate the changes in plasma antithrombin activity during long-term MgSO4 administration for patients without severe hypertension. This multicenter retrospective study included patients with preeclampsia and superimposed preeclampsia without severe hypertension at diagnosis. The participants were divided into two groups: MgSO4 nontreatment group (three institutions) and MgSO4 treatment group (one institution). Antithrombin activity from time of diagnosis to delivery were compared between the two groups. In the MgSO4 nontreatment group (n = 16), antithrombin activity prior to delivery was significantly lower than at time of diagnosis (p = 0.015). In three cases, antithrombin activity was less than 60%. On the other hand, in the MgSO4 treatment group (n = 34), antithrombin activity did not change until just before delivery (p = 0.74). There were no cases in which antithrombin activity was decreased below 60%. Long-term MgSO4 administration for preeclampsia without severe hypertension may prevent a decrease in antithrombin activity and improve the disease state of preeclampsia.
  • Megumi Aki; Miyu Katsumata; Koji Yamanoi; Akihiko Ueda; Baku Nakakita; Hirohiko Tani; Kaoru Kawasaki; Yoshitsugu Chigusa; Haruta Mogami; Masaki Mandai; Eiji Kondoh
    Taiwanese journal of obstetrics & gynecology 61 2 243 - 248 2022年03月 
    OBJECTIVE: To investigate the factors that stratify high-risk cases among subchorionic hematomas (SCHs) patients with persistent vaginal bleeding in early pregnancy. MATERIALS AND METHODS: A total of 56 patients who required hospitalization for SCH with vaginal bleeding in early pregnancy were classified into two groups: 1) no hematoma by ultrasonography when vaginal bleeding occurred, and then hematoma was observed by ultrasonography "bleeding to hematoma (BH group, n = 15)" and 2) no vaginal bleeding when hematoma was observed by routine ultrasonography, and then vaginal bleeding occurred later "hematoma to bleeding (HB group, n = 41)". Retrospective cohort study was performed and maternal and neonatal outcomes were evaluated. RESULTS: The duration of SCHs and/or vaginal bleeding was significantly longer in the BH group than in the HB group (mean: 60.8 days [BH group] vs. 33.3 days [HB group], p = 0.015). BH group patients delivered earlier than HB group patients significantly (mean: 27.3 weeks [BH group] vs. 35.6 weeks [HB group], p = 0.0028). The frequency of chronic abruption and oligohydramnios sequence (CAOS) was significantly higher in the BH group than in the HB group (3/15; 20.0% [BH group] vs. 0/41; 0.0% [HB group], p = 0.016). The frequency of sever fetal distress (Apgar score <4 points) was significantly higher in the BH group than in the HB group (4/15; 26.7% [BH group] vs. 0/41; 0.0% [HB group], p = 0.0037). The levels of factor XIII were relatively lower in the BH group than in the HB group (mean: 54.8% (n = 4) [BH group] vs. 76.1% (n = 7) [HB group], p = 0.077). CONCLUSION: The order of the symptoms, bleeding first, is an important feature that reflects the subsequent prolonged duration of SCHs/vaginal bleeding, resulting in very early preterm delivery. Continuous hemorrhage consumes coagulation factor XIII, which further worsen the hemostasis.
  • Miki Ohtsuki; Yoshitsugu Chigusa; Haruta Mogami; Akihiko Ueda; Kaoru Kawasaki; Ken Yamaguchi; Masaki Mandai; Eiji Kondoh
    Taiwanese journal of obstetrics & gynecology 61 2 277 - 281 2022年03月 
    OBJECTIVE: Although cyclooxygenase inhibitors effectively suppress uterine contraction, constriction of the fetal ductus arteriosus (DA) and oligohydramnios are major concerns. Celecoxib, a selective cyclooxygenase 2 inhibitor, is a potential potent tocolytic agent, but there are no studies that have evaluated the beneficial or adverse effects of celecoxib use on fetuses for more than 48 hours in pregnant women. We therefore aimed to evaluate the effect of middle-long-term celecoxib administration on the fetus during the second trimester of pregnancy, particularly in terms of fetal DA and amniotic fluid volume. MATERIALS AND METHODS: We retrospectively extracted and reviewed data from patients with preterm labor who received celecoxib for tocolysis for more than 48 hours between 2016 and 2020. Celecoxib was used for tocolysis only when treatment of patients with conventional tocolytic agents was ineffective. Data on the peak systolic velocity in ductus arteriosus (PSV-DA) and the maximum vertical pocket (MVP) were collected. RESULTS: A total of 15 patients were eligible. The median gestational age at celecoxib introduction was 22.6 weeks, and the median period of administration was 9 days (range 3-40 days). The median gestational age at delivery was 27.1 weeks, and the median duration from initial celecoxib administration to delivery was 40 days. The Z scores of PSV-DA and MVP did not change significantly after celecoxib administration. During administration, PSV-DA exceeded the 95th percentile of the corresponding normal reference range in three cases, but the levels returned to normal after reduction or discontinuation of treatment. There was no oligohydramnios during the treatment. CONCLUSION: Celecoxib administration for more than 48 hours in the second trimester of pregnancy might be safe and tolerable in terms of fetal PSV-DA and amniotic fluid volume as long as careful ultrasound monitoring is performed. Celecoxib could be an alternative for preterm labor when conventional tocolysis is not effective.
  • Maternal and perinatal outcomes according to blood pressure levels for prehypertension: A review and meta-analysis
    Suzuki H, Takagi K, Matsubara K, Mito A, Kawasaki K, Nanjo S, Mimura K, Bokuda K, Makino S, Nakamoto O, Ichihara A, Seki H
    Hypertension Research in Pregnancy 10 29 - 39 2022年
  • 多賀 悠希子; 川﨑 薫; 安田 枝里子; 川村 明緒; 山口 綾香; 佐藤 麻衣; 最上 晴太; 近藤 英治; 万代 昌紀
    日本周産期・新生児医学会雑誌 58 1 76 - 82 一般社団法人 日本周産期・新生児医学会 2022年
  • Mai Sato; Asako Inohaya; Eriko Yasuda; Haruta Mogami; Yoshitsugu Chigusa; Kaoru Kawasaki; Yosuke Kawamura; Yusuke Ueda; Hiroshi Takai; Masaki Mandai; Eiji Kondoh
    Scientific Reports 11 1 14167 - 14167 2021年12月 
    AbstractPlacental dysfunction is related to the pathogenesis of preeclampsia and fetal growth restriction, but there is no effective treatment for it. Recently, various functional three-dimensional organs have been generated from human induced-pluripotent cells (iPSCs), and the transplantation of these iPSCs-derived organs has alleviated liver failure or diabetes mellitus in mouse models. Here we successfully generated a three-dimensional placental organ bud from human iPSCs. The iPSCs differentiated into various lineages of trophoblasts such as cytotrophoblast-like, syncytiotrophoblast-like, and extravillous trophoblast-like cells, forming organized layers in the bud. Placental buds were transplanted to the murine uterus, where 22% of the buds were successfully engrafted. These iPSC-derived placental organ buds could serve as a new model for the study of placental function and pathology.
  • Yoshitsugu Chigusa; Haruta Mogami; Sachiko Minamiguchi; Aki Kido; Ayami Ishida; Yasuhisa Kurata; Eriko Yasuda; Kaoru Kawasaki; Akihito Horie; Ken Yamaguchi; Masaki Mandai; Eiji Kondoh
    The Journal of Maternal-Fetal & Neonatal Medicine 1 - 7 2021年05月 
    AIM: The pathogenic mechanism of chronic abruption-oligohydramnios sequence (CAOS) remains unknown, and there are no objective standards for diagnosis on imaging or using pathological evidence. We aimed to reconsider and clarify the true pathology of CAOS by integrating clinical, magnetic resonance imaging (MRI) and histopathological findings of the placenta. MATERIAL AND METHODS: This is a case series of patients with CAOS managed at our hospital between 2010 and 2020. The clinical data of the patients, including MRI findings and placental pathology, were reviewed retrospectively. RESULTS: A total of 18 patients were eligible. Preterm birth occurred in 17 (94%) cases; the median gestational age at delivery was 25. Three neonates (17%) died within two years, and 10 neonates (56%) developed chronic lung disease. MRI was performed in 13 cases and clearly showed intrauterine hematoma and hemorrhagic amniotic fluid. Pathologically, in all cases, retroplacental hematoma was not detected, and fetal membranes were extremely fragile and ragged. Shedding and necrosis of the amniotic epithelium was a characteristic finding, which was confirmed in 17 cases (94%). Diffuse chorionic hemosiderosis (DCH) was detected in all cases. CONCLUSIONS: The fundamental cause of CAOS is repeated intrauterine hemorrhage and subsequent subchorionic hematoma, which induces hemorrhagic amniotic fluid and DCH. Consequently, these factors result in the necrosis and weakening of the amnion. Therefore, the true pathology of CAOS is believed to be premature rupture of membranes rather than chronic abruption.
  • Ryuji Kawaguchi; Koji Matsumoto; Tetsuya Ishikawa; Ken Ishitani; Ryugo Okagaki; Mariko Ogawa; Toshimichi Oki; Nobuaki Ozawa; Kaoru Kawasaki; Yoshimitsu Kuwabara; Kaori Koga; Yuichi Sato; Yasushi Takai; Kyoko Tanaka; Kyoko Tanebe; Masakazu Terauchi; Yukiharu Todo; Sayaka Nose-Ogura; Tsuneo Noda; Tsukasa Baba; Eriko Fujii; Takuma Fujii; Hiroaki Miyazaki; Osamu Yoshino; Kazuaki Yoshimura; Tsugio Maeda; Yoshiki Kudo; Hiroshi Kobayashi
    Journal of Obstetrics and Gynaecology Research 47 1 5 - 25 2021年01月 
    Nine years after the first edition of The Guideline for Gynecological Practice, which was jointly edited by The Japan Society of Obstetrics and Gynecology and The Japan Association of Obstetricians and Gynecologists, the 4th Revised Edition was published in 2020. The 2020 Guidelines includes 4 additional clinical questions (CQ), which brings the total to 99 CQ (12 on infectious disease, 29 on oncology and benign tumors, 29 on endocrinology and infertility and 29 on healthcare for women). Currently, a consensus has been reached on the Guidelines, and therefore, the objective of this report is to present the general policies regarding diagnostic and treatment methods used in standard gynecological outpatient care that are considered appropriate. At the end of each answer, the corresponding Recommendation Level (A, B, C) is indicated.
  • Akihiko Ueda; Yoshitsugu Chigusa; Haruta Mogami; Kaoru Kawasaki; Akihito Horie; Masaki Mandai; Eiji Kondoh
    The Journal of Maternal-Fetal & Neonatal Medicine 1 - 6 2020年11月 
    PURPOSE: To identify predictors of systemic lupus erythematosus (SLE) flares during pregnancy in patients previously considered to be at low risk. MATERIALS AND METHODS: The retrospective cohort study included 54 singleton pregnancies, managed between 2005 and 2019, involving maternal diagnosed SLE at a low disease activity (SLE Disease Activity Index ≤4) for ≥12 months before conception and without anti-phospholipid antibodies. Pregnancy outcomes were compared between patients who had SLE exacerbations during pregnancy (flare group, n = 21) and patients that did not have a flare (non-flare group, n = 33). RESULTS: The flare group had shorter gestational durations (p = .01), lower birth weights (p = .02), and a higher risk of emergent cesarean section (p = .002) compared with the non-flare group. The flare group demonstrated higher doses of prednisone (p = .04) at the time of conception as well as an increased rate of low 50% hemolytic complement (CH50) activity (p = .03) in the first trimester compared to the non-flare group. A decision tree drawn using a prednisone dose ≥10.5 mg/day and a low CH50 predicted SLE flares with a net accuracy of 78%. CONCLUSIONS: A prednisone dose ≥10.5 mg daily and CH50 hypocomplementemia in early pregnancy are useful in the early detection of patients at a high risk of SLE exacerbation.
  • Shimpei Shitanaka; Yoshitsugu Chigusa; Shunsuke Kawahara; Kaoru Kawasaki; Haruta Mogami; Masaki Mandai; Eiji Kondoh
    Journal of Obstetrics and Gynaecology Research 46 10 1982 - 1987 2020年10月 
    AIM: The aim of the study was to investigate the efficacy of conservative treatment in cases of retained products of conception (RPOC) with a preceding pregnancy of less than 22 weeks and to assess whether serum beta-human chorionic gonadotropin (hCG) levels could be a useful index to monitor the progress of treatment. METHODS: This is a case series of patients with RPOC developed after less than 22 weeks of gestation and managed expectantly with serial serum hCG measurement between 2011 and 2017. The clinical data of subjects were reviewed retrospectively. Cases that did not require invasive treatment such as surgery were designated as conservative management success. RESULTS: A total of 19 cases were eligible: 14 miscarriages and 5 induced abortions. Eleven patients underwent dilatation and curettage. The diagnosis of RPOC was made 35 (8-80) days after abortion. All patients were successfully treated with conservative management. Serum hCG levels at diagnosis were 29.6 (3.2-1585) mIU/mL. Serial measurement of serum hCG was continued until the levels became lower than the cutoff value, and the mean duration to hCG disappearance was 67.5 (6-183) days. In all cases, RPOC vanished spontaneously 77 (27-184) days after diagnosis. The disappearance of RPOC in the uterine cavity was subsequent to a significant decrease in serum hCG. Once serum hCG levels reached the cutoff value, no bleeding episodes were observed. CONCLUSION: Conservative management for RPOC might be acceptable and effective. Furthermore, serial serum hCG levels reflect the activity of RPOC, and hCG may be a reliable index to monitor the progress of treatment.
  • Shingo Io; Eiji Kondoh; Yoshitsugu Chigusa; Kaoru Kawasaki; Masaki Mandai; and Shigehito Yamada
    Human Reproduction Update 26 5 611 - 633 2020年09月 
    Abstract Many pregnancy complications are the result of dysfunction in the placenta. The pathogenic mechanisms of placenta-mediated pregnancy complications, however, are unclear. Abnormal placental development in these conditions begins in the first trimester, but no symptoms are observed during this period. To elucidate effective preventative treatments, understanding the differentiation and development of human placenta is crucial. This review elucidates the uniqueness of the human placenta in early development from the aspect of structural characteristics and molecular markers. We summarise the morphogenesis of human placenta based on human specimens and then compile molecular markers that have been clarified by immunostaining and RNA-sequencing data across species. Relevant studies were identified using the PubMed database and Google Scholar search engines up to March 2020. All articles were independently screened for eligibility by the authors based on titles and abstracts. In particular, the authors carefully examined literature on human placentation. This review integrates the development of human placentation from morphological approaches in comparison with other species and provides new insights into trophoblast molecular markers. The morphological features of human early placentation are described in Carnegie stages (CS), from CS3 (floating blastocyst) to CS9 (emerging point of tertiary villi). Molecular markers are described for each type of trophoblast involved in human placental development. We summarise the character of human trophoblast cell lines and explain how long-term culture system of human cytotrophoblast, both monolayer and spheroid, established in recent studies allows for the generation of human trophoblast cell lines. Due to differences in developmental features among species, it is desirable to understand early placentation in humans. In addition, reliable molecular markers that reflect normal human trophoblast are needed to advance trophoblast research. In the clinical setting, these markers can be valuable means for morphologically and functionally assessing placenta-mediated pregnancy complications and provide early prediction and management of these diseases.
  • 産科DICをきたした分娩後異常出血症例に対する子宮動脈塞栓術の有用性について
    岡本 葉留子; 川崎; 薫 林; 信孝; 小山; 瑠梨子; 大竹; 紀子; 上松; 和彦; 青木; 卓哉; 吉岡 信也
    72 3 224 - 229 2020年
  • Hiroshi Takai; Eiji Kondoh; Haruta Mogami; Kaoru Kawasaki; Yoshitsugu Chigusa; Mai Sato; Yosuke Kawamura; Ryusuke Murakami; Noriomi Matsumura; Ikuo Konishi; Masaki Mandai
    The Journal of Clinical Endocrinology & Metabolism 104 9 4239 - 4252 2019年09月 
    Abstract Context Placental dysfunction is the underlying cause of common major disorders of pregnancy, such as fetal growth restriction and preeclampsia. However, the mechanisms of placental dysfunction are not entirely elucidated. We previously reported 10 reliable preeclampsia pathways based on multiple microarray data sets, among which was the sonic hedgehog (SHH) pathway. In this study, we describe the significant role of SHH signaling involved in placental development and fetal growth. Design The placental expression levels of surrogate markers of the SHH pathway, patched homolog 1 (PTCH1) and glioma-associated oncogene homolog (GLI) 2, were evaluated using quantitative real-time PCR, western blot analysis, and immunohistochemistry. We investigated the underlying mechanisms of the SHH pathway in trophoblast syncytialization, a critical process for placental development and maturation, using primary cytotrophoblasts. Moreover, the potential roles of placental SHH signaling in the regulation of the IGF axis were explored by pathway analysis of microarray data. Finally, the influence of SHH signaling on fetal growth was examined by placental administration of cyclopamine, an SHH pathway inhibitor, to pregnant mice. Results The SHH pathway was downregulated in preeclampsia placentas, and its activation was highly correlated with birth weight. Trophoblast syncytialization was modulated by noncanonical SHH–adenylate cyclase (ADCY) signaling rather than canonical SHH–GLI signaling. The IGF1 receptor pathway was regulated by both noncanonical SHH–ADCY signaling and canonical SHH–GLI signaling. Inhibition of placental SHH signaling significantly reduced fetal weight in mice. Conclusion Placental development and fetal growth were regulated through the SHH pathway via the IGF axis.
  • Kaoru Kawasaki; Eiji Kondoh; Yoshitsugu Chigusa; Yosuke Kawamura; Haruta Mogami; Satoru Takeda; Akihito Horie; Tsukasa Baba; Noriomi Matsumura; Masaki Mandai; Ikuo Konishi
    Hypertension 73 3 671 - 679 2019年03月
  • Ujita Mari; Kondoh Eiji; Chigusa Yoshitsugu; Mogami Haruta; Kawasaki Kaoru; Kiyokawa Hikaru; Kawamura Yosuke; Takai Hiroshi; Sato Mai; Horie Akihito; Baba Tsukasa; Konishi Ikuo; Matsumura Noriomi; Mandai Masaki
    Pregnancy Hypertension: International Journal of Women’s Cardiovascular Health 13 225 - 234 2018年07月
  • Fujita Kohei; Kondoh Eiji; Chigusa Yoshitsugu; Mogami Haruta; Kawasaki Kaoru; Ujita Mari; Fujita Masatoshi; Konishi Ikuo
    Hypertension Research in Pregnancy 5 1 2 - 6 日本妊娠高血圧学会 2017年 [査読有り]
     

    Aim: This study aimed to determine the normal range of the lectin-like oxidised LDL receptor (LOX) index during pregnancy and investigate whether the index can be used as a biomarker of maternal endothelial function.

    Methods: We conducted a prospective pilot study consisting of 12 pregnant women without obstetric or medical complications and eight non-pregnant women at Kyoto University Hospital between March 2011 and March 2012. Endothelial function was evaluated by the reactive hyperaemia index (RHI) using Endo-PAT2000 in early, mid-, and late gestation. Plasma levels of soluble LOX-1 (sLOX-1) and LOX-1 ligand containing apolipoprotein B (LAB) in each gestation period were measured by ELISA. The LOX index was obtained by multiplying plasma levels of LAB with those of sLOX-1.

    Results: The LOX index increased significantly as gestational age advanced. The LOX index, but not LAB or sLOX-1, was correlated with RHI in mid-gestation (R=0.3352, P=0.0486).

    Conclusions: The LOX index during mid-gestation may be a useful biomarker of maternal endothelial function.

  • Yuki Fukutani; Yoshitsugu Chigusa; Eiji Kondoh; Kaoru Kawasaki; Shingo Io; Noriomi Matsumura
    Case Reports in Obstetrics and Gynecology 2017 1 - 4 2017年 
    Pneumocystis pneumonia (PCP) is a life-threatening opportunistic infection that sometimes occurs in immunocompromised patients with human immunodeficiency virus (HIV). Here, we report two extremely rare cases of PCP in non-HIV pregnant women who underwent chemotherapy for malignant lymphoma. Case  1 is a 34-year-old primigravida who was diagnosed with Hodgkin’s lymphoma. She received ABVD chemotherapy and developed PCP at 37 weeks of gestation. After the onset of PCP, emergent cesarean section was performed due to a nonreassuring fetal status. Case  2 is a 31-year-old multigravida with diffuse large B-cell lymphoma who was administered R-CHOP chemotherapy. At 34 weeks of gestation, she complained of dyspnea and developed PCP. She delivered her baby vaginally immediately after the onset of symptoms. Both patients were treated with sulfamethoxazole-trimethoprim (ST) and recovered shortly thereafter. The babies’ courses were also uneventful. PCP remains a serious cause of death, especially in non-HIV patients, and, therefore, appropriate prophylaxis and a prompt diagnosis are imperative.
  • Yu Kanzaki; Eiji Kondoh; Kaoru Kawasaki; Haruta Mogami; Yoshitsugu Chigusa; Ikuo Konishi
    Journal of Obstetrics and Gynaecology Research 42 11 1476 - 1482 2016年11月
  • Akihiko Ueda; Eiji Kondoh; Kaoru Kawasaki; Haruta Mogami; Yoshitsugu Chigusa; Ikuo Konishi
    The Journal of Maternal-Fetal & Neonatal Medicine 29 19 3115 - 3120 2016年10月
  • Nozomi Higashiyama; Eiji Kondoh; Akihiko Ueda; Tsukasa Baba; Haruta Mogami; Kaoru Kawasaki; Yoshitsugu Chigusa; Ikuo Konishi
    Journal of Obstetrics and Gynaecology 36 6 769 - 771 2016年08月
  • Kaoru Kawasaki; Eiji Kondoh; Sachiko Minamiguchi; Fumihiko Matsuda; Koichiro Higasa; Kohei Fujita; Haruta Mogami; Yoshitsugu Chigusa; Ikuo Konishi
    Journal of Obstetrics and Gynaecology Research 42 8 911 - 917 2016年08月 
    A partial molar pregnancy almost always ends in miscarriage due to a triploid fetus. We describe a rare case of a singleton, partial molar pregnancy with a seemingly huge placenta, which continued to delivery of a live-born diploid baby. A 27-year-old primigravida suffered from severe pre-eclampsia and progressive anemia. The uterus was enormously enlarged for the gestational age. A cesarean section was performed because of deterioration of maternal status at 25 weeks' gestation, when more than 3000 mL blood spouted concurrently with the delivery of the placenta. The histological examination showed congestion in the decidua, which indicated disturbance of maternal venous return from the intervillous space. The chromosome complement of the placenta and the neonate were 69,XXX and 46,XX, respectively. We also reviewed all published cases of a singleton, partial molar pregnancy. A literature search yielded 18 cases of a singleton, diploid fetus with partial molar pregnancy. The mean gestational age at delivery was 24.5 ± 6.2 weeks, and fetuses survived outside the uterus in only four cases (22.2%). Intriguingly, previous reports numbered 10 cases with diploid placenta as well as five cases with no karyotyping of the placenta, indicating that they may have included a complete mole in a twin pregnancy or placental mesenchymal dysplasia. In conclusion, this was the first case of placentomegaly that presented manifestations of excessive abdominal distension and maternal severe anemia, and the second case of a singleton, partial molar pregnancy confirmed by chromosome analysis resulting in a diploid living baby.
  • Chigusa Yoshitsugu; Kawasaki Kaoru; Kondoh Eiji; Mogami Haruta; Ujita Mari; Fujita Kohei; Tatsumi Keiji; Takeda Satoru; Konishi Ikuo
    Journal of Obstetrics and Gynaecology Research 42 1 36 - 43 2016年01月
  • Kawata Etsuko; Kondoh Eiji; Kawasaki Kaoru; Baba Tsukasa; Ueda Akihiko; Kido Aki; Konishi Ikuo
    The journal of obstetrics and gynaecology research 41 4 631 - 634 wiley 2015年04月 
    Extensively distended and tortuous vessels on both sides of the uterus are rare incidental findings on transvaginal sonography in early pregnancy. A 31-year-old woman with a history of surgical repair for congenital intestinal stenosis was noted to have utero-ovarian varices on a transvaginal ultrasound examination during her first prenatal visit at 6 weeks' gestation. Magnetic resonance imaging revealed dilated ovarian veins along with infrarenal absence of inferior vena cava as well as the absence of external and common iliac veins. Despite concerns regarding spontaneous utero-ovarian vessels rupture, her antenatal course was uneventful. A vaginal delivery was successfully achieved without any postpartum complication. We also demonstrated an intraoperative view of the utero-ovarian vessels during cesarean section in her subsequent pregnancy. Absence of inferior vena cava and pelvic varices can occur in women with a history of neonatal surgery. Although the risk of utero-ovarian varices rupture remains unclear, vaginal delivery may be safely achieved.
  • Kaoru Kawasaki; Eiji Kondoh; Yoshitsugu Chigusa; Mari Ujita; Ryusuke Murakami; Haruta Mogami; J.B. Brown; Yasushi Okuno; Ikuo Konishi
    MHR: Basic science of reproductive medicine 21 2 217 - 224 2015年02月 
    Pre-eclampsia is a multifactorial disorder characterized by heterogeneous clinical manifestations. Gene expression profiling of preeclamptic placenta have provided different and even opposite results, partly due to data compromised by various experimental artefacts. Here we aimed to identify reliable pre-eclampsia-specific pathways using multiple independent microarray data sets. Gene expression data of control and preeclamptic placentas were obtained from Gene Expression Omnibus. Single-sample gene-set enrichment analysis was performed to generate gene-set activation scores of 9707 pathways obtained from the Molecular Signatures Database. Candidate pathways were identified by t-test-based screening using data sets, GSE10588, GSE14722 and GSE25906. Additionally, recursive feature elimination was applied to arrive at a further reduced set of pathways. To assess the validity of the pre-eclampsia pathways, a statistically-validated protocol was executed using five data sets including two independent other validation data sets, GSE30186, GSE44711. Quantitative real-time PCR was performed for genes in a panel of potential pre-eclampsia pathways using placentas of 20 women with normal or severe preeclamptic singleton pregnancies (n = 10, respectively). A panel of ten pathways were found to discriminate women with pre-eclampsia from controls with high accuracy. Among these were pathways not previously associated with pre-eclampsia, such as the GABA receptor pathway, as well as pathways that have already been linked to pre-eclampsia, such as the glutathione and CDKN1C pathways. mRNA expression of GABRA3 (GABA receptor pathway), GCLC and GCLM (glutathione metabolic pathway), and CDKN1C was significantly reduced in the preeclamptic placentas. In conclusion, ten accurate and reliable pre-eclampsia pathways were identified based on multiple independent microarray data sets. A pathway-based classification may be a worthwhile approach to elucidate the pathogenesis of pre-eclampsia.
  • Iemura Asako; Kondoh Eiji; Kawasaki Kaoru; Fujita Kohei; Ueda Akihiko; Mogami Haruta; Baba Tsukasa; Konishi Ikuo
    The journal of maternal-fetal & neonatal medicine 28 1 106 - 112 Taylor & Francis Group 2015年01月 
    Foetal membranes bulging into the abdominal cavity is a unique initial manifestation of silent or complete uterine rupture during pregnancy. Since silent uterine rupture has potential risk for complete uterine rupture, which leads to acute life-threatening complications for both the mother and baby, it is difficult to determine whether to manage expectantly or surgically, including repair of the uterine wall or termination of the pregnancy, especially in the early second trimester. We present here a case of a herniated amniotic sac with overstretched uterine wall of the fundus presenting as silent uterine rupture, which was incidentally detected on routine ultrasonography at 18 weeks' gestation in a 38-year-old primigravida with a history of myomectomy for diffuse uterine leiomyomatosis. Magnetic resonance imaging examination revealed that the myometrium thickness was fully maintained at the site of the foetal membranes ballooning. The pregnancy was therefore managed expectantly and continued to successful delivery at 30 weeks' gestation. The precise assessment of the uterine wall may be essential to manage a herniated amniotic sac presenting as silent uterine rupture and to optimise the outcome of the pregnancy. We review all cases of a herniated amniotic sac out of focally overstretched uterine wall before 34 weeks' gestation.
  • Saeko Imai; Eiji Kondoh; Kaoru Kawasaki; Haruta Mogami; Akihiko Ueda; Shigeaki Umeoka; Ikuo Konishi
    European Journal of Obstetrics & Gynecology and Reproductive Biology 180 199 - 201 2014年09月
  • Taga, Atsuko; Kondoh, Eiji; Hamanishi, Junzo; Kawasaki, Kaoru; Fujita, Kohei; Mogami, Haruta; Konishi, Ikuo
    Journal of Maternal-Fetal and Neonatal Medicine 27 12 1285 - 1287 2014年08月
  • Ayako Morita; Eiji Kondoh; Kaoru Kawasaki; Kohei Fujita; Haruta Mogami; Sachiko Minamiguchi; Ikuo Konishi
    Journal of Obstetrics and Gynaecology Research 40 4 1118 - 1123 2014年04月
  • Kondoh Eiji; Kawasaki Kaoru; Kawamura Akeo; Ueda Akihiko; Fujita Kohei; Konishi Ikuo
    The journal of maternal-fetal & neonatal medicine 27 3 309 - 311 Informa Healthcare 2014年02月 
    Background: Conservative management for placenta previa accreta (PPA) may be preferred, but uncontrollable hemorrhage sometimes occurs during a cesarean section. Case: We present a case with a successful maneuver for the management of intraoperative hemorrhage in PPA. Profuse hemorrhage occurred due to partial placental separation during a cesarean section. The bleeding was stopped by the placement of intrauterine tamponade balloons with their shafts passed through the anterior abdominal wall. The catheters were removed after 24 h. The patient had no complications, and the placenta spontaneously resorbed three months after delivery. Conclusion: This is a useful addition to the options for management of PPA at cesarean section.
  • Yosuke Kawamura; Eiji Kondoh; Junzo Hamanishi; Kaoru Kawasaki; Kohei Fujita; Akihiko Ueda; Akeo Kawamura; Haruta Mogami; Ikuo Konishi
    Journal of Obstetrics and Gynaecology Research 40 1 67 - 74 2014年01月
  • Yoshitsugu Chigusa; Eiji Kondoh; Haruta Mogami; Fumitomo Nishimura; Mari Ujita; Kaoru Kawasaki; Kohei Fujita; Keiji Tatsumi; Ikuo Konishi
    Reproductive Sciences 20 8 891 - 898 2013年08月
  • Furuta Nozomi; Kondoh Eiji; Yamada Shigehito; Kawasaki Kaoru; Ueda Akihiko; Mogami Haruta; Konishi Ikuo
    European Journal of Obstetrics & Gynecology and Reproductive Biology 167 2 127 - 131 Elsevier Ireland Ltd. 2013年04月 
    Vulvar varicosities are generally not an indication for a caesarean section but in a rare case of severe vulvar varicosities, it would be a controversial issue whether to perform a caesarean section for fear they might rupture during a vaginal delivery. We present a case of huge vulvar varicosities during pregnancy. MRI revealed obstruction of the internal iliac system by the gravid uterus and subsequent incompetence of a collateral pathway via the round ligament vein that emptied into the ovarian vein. The patient went into labour at 38 weeks, and successfully vaginally delivered a baby. The vulvar varicose veins became compressed by the foetal head from the inside, and markedly diminished in size during crowning and after delivery. Women with vulvar varicosities can be allowed to attempt a vaginal birth regardless of their severity. The use of MRI aids in the overall anatomical understanding of vulvar varicosities in pregnancy.
  • Akeo Kawamura; Eiji Kondoh; Junzo Hamanishi; Yosuke Kawamura; Kyoko Kusaka; Akihiko Ueda; Kaoru Kawasaki; Kohei Fujita; Haruta Mogami; Ikuo Konishi
    Journal of Obstetrics and Gynaecology Research 39 3 733 - 737 2013年03月
  • Takekazu Miyoshi; Shinji Katsuragi; Tomoaki Ikeda; Chinami Horiuchi; Kaoru Kawasaki; Chizuko A. Kamiya; Yoshihito Sasaki; Kazuhiro Osato; Reiko Neki; Jun Yoshimatsu
    Fetal Diagnosis and Therapy 34 1 19 - 25 2013年 
    OBJECTIVE: From a single-center retrospective cohort with fetal chylothorax, we evaluated the factors related to the decision to use shunting, poor prognostic factors, and reported shunting outcomes with a new double basket-catheter device. METHODS: A retrospective single-center study was performed in 35 cases of fetal chylothorax. RESULTS: There were 35 cases of chylothorax: 23 with hydrops and 12 without hydrops. Twenty-one procedures were performed on 15 fetuses (11 with hydrops) with a single shunt in 11, two shunts in 3 and four shunts in 1. All 12 nonhydropic cases survived. In 23 hydropic cases, overall survival rates with and without thoracoamniotic shunting were 46 and 33%, respectively. The mortality rates of fetal hydropic cases with and without ascites were 93 and 11%, respectively. Fetal ascites, progression of fetal hydrops, and premature delivery at <33 weeks were significant risk factors for a poor prognosis. Progression of polyhydramnios after shunting was also associated with a poor prognosis. Obstruction of the catheter was observed in 38%. There were no direct fetal deaths associated with shunting. CONCLUSION: Thoracoamniotic shunting should be considered for pleural effusion before development of fetal hydrops, or at least before the appearance of fetal ascites. A double-basket catheter tends to be obstructive, but may be less invasive for fetuses.
  • KAMIYA Chizuko A.; IWAMIYA Tadashi; NEKI Reiko; KATSURAGI Shinji; KAWASAKI Kaoru; MIYOSHI Takakazu; SASAKI Yoshihito; OSATO Kazuhiro; MUROHARA Toyoaki; IKEDA Tomoaki
    Circulation journal : official journal of the Japanese Circulation Society 76 4 957 - 963 The Japanese Circulation Society 2012年 
    Background: Improved medical techniques have allowed most women with repaired tetralogy of Fallot (TOF) to reach childbearing age. The predictors of adverse events and the effects of pregnancy on cardiac function have not been clearly described in these patients. Methods and Results: In the present study we retrospectively reviewed 40 deliveries in 25 patients with repaired TOF. There were 23 patients in New York Heart Association (NYHA) class I, and 2 in classes II-III before pregnancy. The mean age at delivery was 29.1 years and the mean gestational period was 37.8 weeks. Seven pregnancies (17.5%) in 7 patients were complicated with cardiac events such as a decline in NYHA class and arrhythmia. History of ablation and the baseline cardiothoracic ratio on chest radiography were predictors of adverse events. Peak plasma brain natriuretic peptide (BNP) level after the second trimester was higher in patients with cardiac events. Left ventricular size and contraction did not change from before to after pregnancy, but the right ventricle was enlarged at 6 months after delivery. Conclusions: Many of the pregnancies in women with repaired TOF were successful. However, careful management is required for some patients and the BNP level may be a useful marker to identify these patients. Because the right heart tended to be enlarged in the late postpartum period, pregnancy may also affect the long-term prognosis of patients with repaired TOF. (Circ J 2012; 76: 957-963)
  • KATSURAGI Shinji; YAMANAKA Kaoru; NEKI Reiko; KAMIYA Chizuko; SASAKI Yoshihito; OSATO Kazuhiro; MIYOSHI Takekazu; KAWASAKI Kaoru; HORIUCHI Chinami; KOBAYASHI Yoshinari; UEDA Keiko; YOSHIMATSU Jun; NIWA Koichiro; TAKAGI Yaemi; OGO Takeshi; NAKANISHI Norifumi; IKEDA Tomoaki
    Circulation journal : official journal of the Japanese Circulation Society 76 9 2249 - 2254 The Japanese Circulation Society 2012年 
    Background: Pulmonary arterial hypertension (PAH), including Eisenmenger syndrome, has a risk of mortality in pregnancy of 10–40%. The aim of this study was to investigate whether pulmonary artery blood pressure (PABP) is a prognostic factor for pregnancy outcome in patients with PAH. Methods and Results: The subjects were 42 patients with PAH during pregnancy. Severe and mild cases were defined by PABP before and during the first 14 weeks of pregnancy, with severe cases having mean PABP >40mmHg by catheterization or systolic PABP >50mmHg on echocardiography. Eighteen women chose termination of pregnancy before 14 weeks, leaving 24 women (10 mild, 14 severe) for analysis. The women with severe PAH delivered earlier (35.4 vs. 31.5 weeks, P<0.05) and had higher rates of small-for-gestational-age infants (0/10 vs. 7/14, P<0.01). Among the women with severe PAH, the New York Heart Association class dropped by 1 in 9 cases, by 2 in 3 cases, and remained the same in 2 cases as pregnancy progressed, whereas among the women with mild PAH, the class dropped by 1 in 1 case and 9 women remained in the same class. Among the severe cases, 1 woman died and there was 1 fetal death; PABP markedly increased in later pregnancy from 54 to 74mmHg (catheter measurement) and from 78 to 93mmHg (echocardiography) (P<0.05). Conclusions: The level of PABP before or in the early stage of pregnancy is an important predictor of pregnancy outcome.  (Circ J 2012; 76: 2249–2254)
  • 谷 洋彦; 伊東 宏晃; 小阪 謙三; 竹村 真紀; 岡田 由貴子; 川崎 薫; 佐川 典正; 藤井 信吾
    産婦人科の進歩 57 3 309 - 310 近畿産科婦人科学会 2005年
  • 川崎 薫; 伊東 宏晃; 小阪 謙三; 福嶋 亜紀子; 岩見 州一郎; 佐川 典正; 藤井 信吾
    産婦人科の進歩 56 3 381 - 384 近畿産科婦人科学会 2004年08月

書籍

  • 産科婦人科手術で初めて執刀する時に必ずみておく教科書
    (担当:分担執筆範囲:卵巣嚢腫摘出術・付属器切除術)2024年02月
  • 産科と婦人科vol91 No1 産婦人科診療ガイドライン婦人科外来編2023改定のポイント 感染症・女性医学編
    (担当:範囲:7, 子宮内避妊用具（IUD）・レボノルゲストレル放出子宮内システム（LNG-IUS）を装着するときの説明は？)診断と治療者 2024年01月
  • MFICUマニュアル改定4版
    川﨑薫 (担当:分担執筆範囲:意識障害)メディカ出版 2022年06月
  • 胎盤病理アトラス
    川﨑薫 (担当:分担執筆範囲:胎盤の超音波画像 胎盤のMRI像)文光堂 2021年10月
  • 平松, 祐司 (担当:分担執筆範囲:妊娠中の卵巣腫瘍に対する手術)メジカルビュー社 2021年03月 ISBN: 9784758319850 197p
  • 竹田, 省 (担当:分担執筆範囲:前置胎盤の帝王切開術)メジカルビュー社 2020年08月 ISBN: 9784758319836 193p
  • 日本母体救命システム普及協議会; 京都産婦人科救急診療研究会 (担当:分担執筆範囲:2 分娩進行中の子宮破裂)メディカ出版 2020年05月 ISBN: 9784840471886 xi, 355p
  • 産科と婦人科 来たれ！私たちの産婦人科 京都大学医学部附属病院
    川﨑薫 (担当:範囲:第87巻第8号page966-968)診断と治療社 2020年
  • 周産期医学 周産期と悪性腫瘍 卵巣癌
    川﨑薫 (担当:分担執筆範囲:第50巻第9号 page1591-1594, 2020)2020年
  • PERINATAL CARE, 前置胎盤と常位胎盤早期剥離 01病態生理 ～超危険な前置癒着胎盤
    川﨑薫 (担当:分担執筆範囲:第39巻第5号 page12-15)2020年
  • PERINATAL CARE, 妊娠高血圧症候群 新基準とケア 06入院管理と降圧剤
    川﨑薫 (担当:分担執筆範囲:第39巻第２号 page43-47)2020年
  • 日本産科婦人科学会; 日本産婦人科医会 日本産科婦人科学会 2020年 ISBN: 9784990196325 冊
  • 日本産婦人科医会研修ノート103 産科異常出血への対応 手術療法（保存療法）
    川﨑薫 (担当:分担執筆範囲:)2019年
  • Baby;お医者さんがつくった妊娠出産の本
    日本産婦人科学会監修 (担当:分担執筆範囲:「妊娠の兆候と検査薬」「母子健康手帳」「妊婦健診で行う検査」)RECRUITE 2015年
  • 小西, 郁生 (担当:分担執筆範囲:前置胎盤の帝王切開術 妊娠中期)メジカルビュー社 2012年02月 ISBN: 9784758312080 153p

講演・口頭発表等

  • 有床診療所・総合病院での 病院内スタッフ限定コース開催の効果と課題  [招待講演]
    第76回日本産科婦人科学会学術集会 J-CIMELSワークショップ ディレクター・ミーティング ～各地でのJ-MELS継続開催の取り組み〜 2024年04月
  • 鉄欠乏性貧血 高用量鉄剤による治療効果 ～新規静注鉄剤で輸血を回避する～  [招待講演]
    川﨑薫
    モノヴァー静注発売１周年記念Web講演会 2024年03月
  • 産科DICの診断と治療～妊産婦死亡を防ぐためにできること～  [招待講演]
    川崎薫
    第3回周産期麻酔学会年次学術集会 教育講演 2024年02月
  • 血液凝固カスケードから見た周産期合併症～産科DICを中心に～  [招待講演]
    川﨑薫
    大阪温知会学術講演会 2024年02月
  • DIC部会 DIC診療ガイドライン(仮）のお披露目 産科  [招待講演]
    川﨑薫
    第18回日本血栓止血学会学術標準化委員会シンポジウム 2024年02月
  • 周産期における鉄欠乏性貧血の治療意義～高用量静注鉄剤の効果～  [招待講演]
    川﨑薫
    Update Webセミナー ～産科・婦人科医療におけるトータルヘルスケアを目指して～
  • 周産期における鉄欠乏性貧血の治療～高用量鉄剤により輸血を回避する～  [招待講演]
    川﨑薫
    鉄欠乏性貧血を考える会
  • 産科危機的出血 超急性期から回復期までの管理  [招待講演]
    川﨑薫
    姫路産婦人科医会学術講演会 2023年12月
  • 麻酔科医にもやさしい 帝王切開の基本術式と応用  [招待講演]
    川﨑薫
    第127回産科麻酔科学会 2023年12月
  • DIC診療ガイドライン～産科DICの診断と治療～  [招待講演]
    川﨑薫
    日本血液製剤機構 産科DIC WEBセミナー
  • 周産期における鉄欠乏性貧血の治療 ～高用量鉄剤による治療意義～  [招待講演]
    川﨑薫
    ゼリア新薬社内勉強会 2023年10月
  • 周産期における鉄欠乏性貧血の治療 ～高用量鉄剤による治療意義～  [招待講演]
    川﨑薫
    岡山県西部地区産婦人科研究会 2023年09月
  • 帝王切開と癒着防止  [招待講演]
    川﨑薫
    科研製薬 社内勉強会 2023年09月
  • 周産期における鉄欠乏性貧血の治療 ～高用量鉄剤による治療意義～  [招待講演]
    川﨑薫
    鉄欠乏性貧血セミナー～高用量静鉄剤の選択肢～ 2023年09月
  • 産婦人科における鉄欠乏性貧血の治療 ～高用量鉄剤による治療意義～  [招待講演]
    川﨑薫
    日常診療におけるIron defficiency anemia 最新治療 ～より高いQOLを目指して～ 2023年08月
  • 胎児心拍数陣痛図の判読  [招待講演]
    京都府看護協会令和5年度新人助産師研修 2023年08月
  • 妊娠産褥期の鉄欠乏性貧血の治療 ～周産期予後向上を目指して～  [招待講演]
    血液疾患連携の会 2023年07月
  • 妊娠中の卵巣腫瘍に対する腹腔鏡下手術の安全性と工夫 ～開腹手術とのちがい～  [招待講演]
    日本周産期新生児医学会 2023年07月
  • 周産期における鉄欠乏性貧血の管理  [招待講演]
    川崎薫
    第148回近畿産婦人科学会学術集会 教育セミナー 2023年06月
  • 産科DICの診断と治療 ～妊産婦死亡を防ぐために～  [招待講演]
    川崎薫
    第45回日本血栓止血学会学術集会 会長企画シンポジウム 「播種性血管内凝固症（DIC）の基礎疾患別の病態・治療戦略」 2023年06月
  • 周産期における血液凝固異常症の早期発見に役立つ検査 ～産科DICスコア改訂版と新規バイオマーカーについて～  [招待講演]
    川﨑薫
    第66回日本臨床検査医学会近畿支部例会 2023年05月
  • 産科DICと 先天性血液凝固異常症合併妊娠  [招待講演]
    川﨑薫
    一般社団法人日本血液製剤機構 機構内勉強会 2023年04月
  • 妊娠中の貧血の治療 周産期予後向上を目指して  [招待講演]
    あすか製薬株式会社; 社内研修会
    2023年03月
  • 「DIC診療ガイドライン（仮）の構想と進捗状況」7. 産科  [招待講演]
    川﨑薫
    第17回日本血栓止血学会 学術標準化委員会 SSCシンポジウム 2023年02月
  • 周産期における鉄欠乏性貧血の治療  [招待講演]
    川﨑薫
    日本新薬株式会社 社内招聘勉強会 2023年01月
  • 周産期メンタルヘルス 妊婦貧血の管理  [招待講演]
    第1回ASKA周産期セミナーin兵庫 2022年12月
  • 妊娠・産褥期に血小板低下をきたす疾患 HELLP症候群？それとも？  [招待講演]
    川﨑薫
    Clinical Questionから学ぶ「補体とTMAの世界」 2022年12月
  • 胎児心拍数モニタリング 産科救急  [招待講演]
    川﨑薫
    京都府看護協会令和4年度新人助産師研修 2022年08月
  • 産科DIC  [招待講演]
    川﨑薫
    日本血栓止血学会 教育講演 2022年06月
  • あすか産婦人科セミナー 周産期貧血治療 ～周産期における貧血とその治療～  [招待講演]
    川﨑薫
    2022年03月
  • 妊娠高血圧症候群 重症化を防ぐために  [招待講演]
    第１回上本町産婦人科セミナー 2021年10月
  • 京都府看護協会令和3年度新人助産師研修  [招待講演]
    胎児心拍数モニタリング
  • 第72回産婦人科診療ガイドライン外来編2020解説講演
    川﨑薫
    日本産科婦人科学会学術講演会
  • 産科出血ハンズオンセミナー 子宮圧迫縫合  [招待講演]
    川﨑薫
    第43回産婦人科手術学会 2020年11月
  • 妊娠中の静脈血栓塞栓症  [招待講演]
    川﨑薫
    Meeting of Venous Thromboembolism 2020年01月
  • 精神疾患合併妊娠における精神障害増悪リスク因子についての検討
    川﨑薫; 柳川真澄; 山添紗恵子; 﨑山明香; 松林彩; 林信孝; 小山瑠梨子; 田邉更衣子; 大竹紀子; 上松和彦; 青木卓哉; 吉岡信也
    第56回日本周産期新生児医学会学術講演会 2019年07月
  • 前置胎盤のリスク評価に対するMRIの有用性についての検討
    川﨑薫; 柳川真澄; 山添紗恵子; 﨑山明香; 松林彩; 林信孝; 小山瑠梨子; 田邉更衣子; 大竹紀子; 上松和彦; 青木卓哉; 吉岡信也
    第71回日本産科婦人科学会学術講演会 2019年04月
  • 遺伝子発現データの統合的解析に基づく妊娠高血圧腎症に対する新規治療法の開発  [招待講演]
    川﨑薫
    キッセイ薬品工業株式会社 社内研修会講演 2018年11月
  • 胎児発育不全のスクリーニング法  [招待講演]
    川﨑薫
    日本超音波医学会;関西地方会学術集会 2018年10月
  • 当院で緊急頸管縫縮術を施行した11例の後方視的検討
    川﨑薫; 山村幸; 小椋恵利; 松坂優; 髙倉賢人; 宇治田麻里; 山口建; 高尾由美; 髙倉賢二; 小西郁生
    京都周産期カンファレンス 2017年11月
  • 妊娠高血圧腎症の胎盤におけるグルタチオン合成酵素の発現と硫酸マグネシウムによる効果
    川﨑薫
    第24胎盤学会学術集会 シンポジウム 2016年11月
  • Magnesium sulfate may ameliorate oxidative stress and inflammation in preeclampsia
    第68回日本産科婦人科学会学術講演会international session 2016年04月
  • MgSO4 potentiates anti-inflammatory and anti-oxidant activities in trophoblast cell
    Kawasaki K, Kondoh E, Chigusa Y, Murakami R, Takai H, Ujita M, Mogami H, J.B. Brown, Yasushi O, Takeda S, Konishi I
    46th International Congress on Pathophysiology of Pregnancy 2014年09月
  • Integrative Genomic Analysis of Preeclamptic Placentas Identifies Glutathione;GABA Receptor Pathways;as Novel Therapeutic Targets of Preeclampsia
    Kawasaki K; Kondoh E; Chigusa Y; Murakami R; Ujita M; Mogami H; Takeda S; Konishi I
    61st Annual Meeting of the Society for Gynecologic Investigation, Florence, Italy 2014年03月

MISC

受賞

  • 2015年09月 第46回国際妊娠病態生理学会 Young Doctor Award
  • 2015年 ヒューマンメタボローム株式会社 先導研究助成大賞
  • 2014年09月 第34回妊娠高血圧学会学術集会 学術奨励賞

共同研究・競争的資金等の研究課題

  • 腸内細菌を標的とした妊娠高血圧腎症の創薬開発
    日本学術振興会：科学研究費助成事業 若手研究
    研究期間 : 2021年04月 -2026年03月 
    代表者 : 川崎 薫
  • バイオマーカーと超音波検査を組み合わせた妊娠高血圧腎症の発症・予後 予測法の開発
    近畿大学学内研究助成金：
    研究期間 : 2024年03月 -2024年03月 
    代表者 : 川﨑薫
  • Sonic hedgehog pathwayをターゲットとした胎盤機能不全に対する新規治療法の開発
    神澤医学振興財団研究助成：
    研究期間 : 2017年04月
  • 硫酸マグネシウムは妊娠高血圧腎症の病態改善に寄与しうる
    藤原記念財団：
    研究期間 : 2016年04月 -2017年03月

委員歴

  • 2023年08月 - 現在   令和５年度厚生労働科学研究費補助金 難治性疾患等政策研究事業 血液凝固異常症等に関する研究班 特発性血栓症研究班研究協力者
  • 2023年06月 - 現在   大阪産婦人科医会   医療安全委員会
  • 2022年07月 - 現在   日本周産期新生児医学会   専門医精度委員会施設認定委員会委員
  • 2022年07月 - 現在   日本周産期新生児医学会   臨床研究審査委員会委員
  • 2022年07月 - 現在   日本血栓止血学会   DIC部会委員
  • 2022年07月 - 現在   日本周産期新生児医学会   評議員
  • 2021年04月 - 現在   近畿産婦人科学会   周産期部会委員
  • 2021年04月 - 現在   大阪OGCS   運営委員会 委員
  • 2016年10月 - 現在   日本産婦人科医会   研修委員会 委員
  • 2020年04月 - 2023年03月   日本産婦人科医会   産婦人科診療ガイドライン2023 外来編 編集委員
  • 2017年04月 - 2020年03月   日本産婦人科医会   産婦人科診療ガイドライン2020 外来編 編集委員
  • 2020年   日本妊娠高血圧学会   妊婦の高血圧診断基準に関する検討委員会委員
  • 2015年 - 2016年   日本産科婦人科学会   未来委員会 若手委員
  • 2016年   日本産科婦人科学会   サマースクール若手実行委員会 委員長
  • 2014年 - 2015年   日本産科婦人科学会   未来ビジョン委員会 委員

社会貢献活動

  • 日本母体救命システム普及協議会 母体救命ベーシックコース コースディレクター
    期間 : 2012年 - 現在
    役割 : 講師
    種別 : 資格認定講習
  • 日本周産期・新生児医学会 新生児蘇生法「専門」コース インストラクター
    期間 : 2009年 - 現在
    役割 : 講師
    種別 : 資格認定講習

学術貢献活動

  • 日本産婦人科医会 研修委員会 研修ノート監修
    期間 : 2016年 - 現在
    役割 : 監修

その他のリンク

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