詳細

河村　尚幸 （カワムラ　タカユキ）

  • 医学科　医学部講師
Last Updated :2024/04/25

コミュニケーション情報 byコメンテータガイド

  • コメント

    循環器内科全般

研究者情報

学位

  • 学士（医学） 近畿大学

ホームページURL

科研費研究者番号

  • 40642848

J-Global ID

現在の研究分野（キーワード）

    循環器内科全般

研究分野

  • ライフサイエンス / 循環器内科学

研究活動情報

論文

  • Kenji Yamaji; Yoshitaka Iwanaga; Kazuyoshi Kakehi; Kosuke Fujita; Takayuki Kawamura; Chikara Hirase; Masafumi Ueno; Gaku Nakazawa
    International heart journal 65 1 13 - 20 2024年 
    Recent studies have showed that asymptomatic cerebral infarction (ACI) developed in a reasonable number of patients after cardiac catheterization. However, no study has investigated the long-term prognostic impact of ACI after cardiac catheterization. We investigated whether ACI after cardiac catheterization affects long-term mortality and subsequent cardiovascular events.We retrospectively enrolled patients who underwent cardiac catheterization before cardiac surgery and cerebral diffusion-weighted magnetic resonance imaging (DWI). The incidence and clinical features of ACI were investigated. The long-term prognosis, including all-cause mortality and subsequent major cardiovascular events (MACE; all-cause mortality, stroke, acute myocardial infarction, fatal arrhythmia, and hospitalized heart failure), was also assessed.A total of 203 patients were enrolled. Of these, 10.3% had ACI diagnosed by DWI. There were no differences in baseline characteristics between patients with and without ACI, except more frequent history of symptomatic stroke in patients with ACI. In the Kaplan-Meier analysis during a median follow-up of 1009 days, the patients with ACI showed worse mortality and a slightly higher occurrence of MACE compared with those without ACI (P = 0.01 and P = 0.08, respectively). In addition, ACI was a prognostic marker independent of age, surgery type, and history of stroke.ACI after cardiac catheterization frequently developed and was also associated with long-term prognosis. It may be an independent prognostic marker in high-risk patients who underwent subsequent cardiac surgery.
  • Kazuyoshi Kakehi; Masafumi Ueno; Takayuki Kawamura; Nobuhiro Yamada; Kuniaki Takahashi; Kosuke Fujita; Masakazu Yasuda; Koichiro Matsumura; Tatsuya Miyoshi; Kazuki Mizutani; Toru Takase; Genichi Sakaguchi; Gaku Nakazawa
    Journal of cardiology 2023年08月 
    BACKGROUND: Early prediction of aorta-related events is important for determining subsequent treatment strategies in patients with acute aortic dissection. However, most studies evaluated long-term aortic growth rates by annual assessment. The purpose of our study was to determine whether the in-hospital growth rate of aortic volume was associated with aorta-related events. METHODS: We studied 116 patients with uncomplicated type B acute aortic dissection. We analyzed whether changes in aortic volume were associated with aorta-related events during a 5-year follow-up. According to the growth rate from admission to discharge, patients were divided into two groups: Increase >0 (aortic volume: n = 59, aortic diameter: n = 43) and Reduction ≤0 (aortic volume: n = 57, aortic diameter: n = 73) in maximum aortic diameter or aortic volume. The primary endpoint was the discriminative ability of the growth rate of aortic volume for aorta-related events. RESULTS: According to the evaluation of aortic volume changes, the Increase group had significantly higher aorta-related event rates than those in the Reduction group (49.2 % vs. 3.5 %, respectively; p < 0.001). Receiver operating characteristics analysis showed that the growth rate of aortic volume had a clearly useful discrimination, with an area under the curve of 0.84, whereas the discriminative ability of the growth rate of maximum aortic diameter was poor (area under the curve: 0.53). Multivariate analysis showed that the growth rate of aortic volume from admission to discharge was an independent predictor of aorta-related events (hazard ratio, 26.3; 95 % confidence interval, 2.04-286.49; p = 0.001). CONCLUSIONS: In-hospital evaluation of aortic volume was helpful to predict long-term aorta-related events in patients with uncomplicated type B acute aortic dissection.
  • Yu Kataoka; Satoshi Yasuda; Yasuhide Asaumi; Satoshi Honda; Teruo Noguchi; Yoshihiro Miyamoto; Kazuhiro Sase; Noriaki Iwahashi; Takayuki Kawamura; Masami Kosuge; Kazuo Kimura; Itaru Takamisawa; Yoshitaka Iwanaga; Shunichi Miyazaki
    Journal of diabetes and its complications 37 5 108469 - 108469 2023年05月 
    AIMS: To elucidate the long-term cardiovascular benefit of lowering postprandial hyperglycemia (PPG) in early-stage T2DM patients. METHODS: This 10-year post-trial follow-up study included 243 patients from the DIANA (DIAbetes and diffuse coronary Narrowing) study, a multi-center randomized controlled trial which compared the efficacy of one-year life-style and pharmacological (voglibose/nateglinide) intervention lowering PPG on coronary atherosclerosis in 302 early-stage T2DM subjects [impaired glucose tolerance (IGT) or newly-diagnosed T2DM] (UMIN-CTRID#0000107). MACE (all-cause death, non-fatal MI or unplanned coronary revascularization) were compared in (1) three assigned therapies (life-style intervention/vogliose/nateglinide) and (2) patients with and without improvement of PPG (reversion from IGT to NGT or from DM to IGT/NGT on 75 g oral glucose tolerance test). RESULTS: During the 10-year post-trial observational period, voglibose (HR = 1.07, 95%CI: 0.69-1.66, p = 0.74) or nateglinide (HR = 0.99, 95%CI: 0.64-1.55, p = 0.99) did not reduce MACE. Similarly, achieving the improvement of PPG was not associated with a reduction of MACE (HR = 0.78, 95%CI: 0.51-1.18, p = 0.25). However, in IGT subjects (n = 143), this glycemic management significantly reduced the occurrence of MACE (HR = 0.44, 95%CI: 0.23-0.86, p = 0.01), especially unplanned coronary revascularization (HR = 0.46, 95%CI: 0.22-0.94, p = 0.03). CONCLUSIONS: The early improvement of PPG significantly reduced MACE and unplanned coronary revascularization in IGT subjects during the post-trial 10-year period.
  • Prognostic Impact of TIMI Frame Count in Patients with Dilated Cardiomyopathy(タイトル和訳中)
    Kawamura Takayuki; Matsumura Koichiro; Funauchi Yohei; Soejima Naoko; Okune Mana; Kakehi Kazuyoshi; Yasuda Masakazu; Mizutani Kazuki; Ueno Masafumi; Nakazawa Gaku
    日本循環器学会学術集会抄録集 87回 PE52 - 1 2023年03月
  • Association of Lifestyle Changes and Weight Gain in Adult Population during the COVID-19 Pandemic(タイトル和訳中)
    松村 光一郎; 八木 英次郎; 高林 健介; 伊地知 健; 長谷川 実咲; 大西 教平; 筧 和剛; 河村 尚幸; 上野 雅史; 中澤 学
    日本循環器学会学術集会抄録集 87回 OJ40 - 2 2023年03月
  • Kenji Yamaji; Yoshitaka Iwanaga; Takayuki Kawamura; Kosuke Fujita; Masakazu Yasuda; Toru Takase; Chikara Hirase; Masafumi Ueno; Gaku Nakazawa
    Journal of Cardiology 2022年02月
  • 負荷心エコー図検査の現状と未来 当院における負荷エコーの現状と有用性
    奥根 真楠; 平野 豊; 副島 奈央子; 河村 尚幸; 三好 達也; 中澤 学
    超音波医学 48 Suppl. S212 - S212 (公社)日本超音波医学会 2021年04月
  • 黄色プラークのグレードの高さは末梢動脈疾患患者の死亡率に関する新規予測因子である 血管造影による解析(Higher Grade of Yellow Plaque Color is a Novel Predictor for Mortality in Patients with Peripheral Arterial Disease: Angioscopy Analysis)
    山治 憲司; 岩永 善高; 藤田 晃輔; 河村 尚幸; 安田 昌和; 渡邉 平太郎; 高瀬 徹; 中村 貴; 上野 雅史; 中澤 学
    日本循環器学会学術集会抄録集 85回 OJ68 - 6 2021年03月
  • Higher Grade of Yellow Plaque Color is a Novel Predictor for Mortality in Patients with Peripheral Arterial Disease: Angioscopy Analysis(和訳中)
    山治 憲司; 岩永 善高; 藤田 晃輔; 河村 尚幸; 安田 昌和; 渡邉 平太郎; 高瀬 徹; 中村 貴; 上野 雅史; 中澤 学
    日本循環器学会学術集会抄録集 85回 OJ68 - 6 2021年03月
  • Mana Okune; Masakazu Yasuda; Naoko Soejima; Kazuyoshi Kakehi; Takayuki Kawamura; Takashi Kurita; Gaku Nakazawa; Yoshitaka Iwanaga
    Frontiers in cardiovascular medicine 8 781125 - 781125 2021年 
    Aims: The clinical impact of the type of atrial fibrillation (AF) has not been completely elucidated in non-ischemic cardiomyopathy (NICM). Although the structure and function of the left atrium (LA) provide prognostic information in patients with heart failure, the relationship of the AF type with LA structure and function in NICM is unclear. Methods: Consecutive patients with NICM who underwent cardiac magnetic resonance were evaluated and followed. Multivariable Cox regression models were used to estimate hazard ratios (HRs) for major adverse cardiovascular events (MACE) related to the AF type, such as paroxysmal AF, chronic AF, and new-onset AF (NOAF). Results: Among 625 patients with NICM (mean age, 64.4 ± 14.2 years; women, 39.7%), 133 had a history of AF at baseline; of these, 60 had paroxysmal AF. Each baseline AF type was associated with higher LA volume and lower LA emptying fraction but not with an increased incidence of MACE (p = 0.245). New-onset AF developed in 5.9% of patients with sinus rhythm over a median follow-up period of 609 days, and maximum LA volume was a strong and independent predictor [p < 0.001, area under the ROC curve (AUC): 0.795]. Maximum LA volume was superior to LA emptying fraction and B-type natriuretic peptide (AUC: 0.683 and 0.680, respectively). The use of β-blocker and the age of the patient were associated with the incidence of NOAF (HR: 0.37, 95% CI: 0.16-0.84 and HR: 1.05, 95% CI: 1.01-1.09, respectively). Kaplan-Meier analysis showed that patients with NOAF had a higher incidence of MACE than those with sinus rhythm or baseline AF (p = 0.002). NOAF and LA emptying fraction were independent predictors of MACE (HR: 2.28, 95% CI: 1.20-3.97 and HR: 0.98, 95% CI: 0.96-0.99, respectively) after adjusting for age, sex, body mass index, and diagnosis. Conclusions: Paroxysmal and chronic AF in patients with NICM were not associated with an increased incidence of MACE despite their association with LA volume and function. NOAF was independently associated with poor prognosis. Higher maximum LA volume predicted the onset and lower LA emptying fraction was independently associated with poor prognosis.
  • Mana Okune; Masakazu Yasuda; Naoko Soejima; Yoshinori Kagioka; Kazuyoshi Kakehi; Takayuki Kawamura; Kohei Hanaoka; Hayato Kaida; Kazunari Ishii; Gaku Nakazawa; Shunichi Miyazaki; Yoshitaka Iwanaga
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 29 2 753 - 764 2020年10月 
    BACKGROUND: Although each 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE) has been used to diagnose cardiac sarcoidosis (CS), active CS is still misdiagnosed. METHODS: Active CS, diagnosed by PET alone, was defined as focal or focal on diffuse FDG uptake pattern. In fusion PET/CMR imaging, using a regional analysis with AHA 17-segment model, the patients were categorized into four groups: (1) PET-/LGE-, (2) PET+/LGE-, (3) PET+/LGE+, and (4) PET-/LGE+. PET+/LGE+ was defined as active CS. RESULTS: 74 Patients with suspected CS were enrolled. Between PET alone and fusion PET/CMR imaging, 20 cases had mismatch evaluations of active CS, and most had diffuse or focal on diffuse FDG uptake pattern on PET alone imaging. 40 Patients fulfilled the 2016 the Japanese Circulation Society diagnostic criteria for CS. The interobserver diagnostic agreement was excellent (κ statistics 0.89) and the overall accuracy for diagnosing CS was 87.8% in fusion PET/CMR imaging, which were superior to those in PET alone imaging (0.57 and 82.4%, respectively). In a sub-analysis of diffuse and focal on diffuse patterns, the agreement (κ statistics 0.86) and overall accuracy (81.8%) in fusion PET/CMR imaging were still better. CONCLUSIONS: Fusion PET/CMR imaging with regional analysis offered reliable and accurate diagnosis of CS, covering low diagnostic area by FDG-PET alone.
  • Yoshinori Kagioka; Masakazu Yasuda; Mana Okune; Kazuyoshi Kakehi; Takayuki Kawamura; Kazuhiro Kobuke; Shunichi Miyazaki; Yoshitaka Iwanaga
    Clinical research in cardiology : official journal of the German Cardiac Society 109 8 988 - 998 2020年08月 
    BACKGROUND: Late gadolinium enhancement imaging (LGE) of the left ventricle (LV) by cardiac magnetic resonance (CMR) has prognostic value for patients with cardiac sarcoidosis (CS). Right ventricle (RV) dysfunction is also associated with adverse outcomes in patients with heart failure. Therefore, we sought to determine if RV LGE and dysfunction predicted adverse events in patients with suspected CS. METHODS: In 103 consecutive patients with suspected CS who underwent CMR, functional and remodeling indexes of both the LV and RV were measured and the extent and localization of LGE were also analyzed. Major adverse cardiac events (MACE) were defined as cardiovascular mortality, severe ventricular tachyarrhythmia, hospitalization with heart failure, and advanced atrioventricular block. RESULTS: During a median follow-up of 20.6 months, Kaplan-Meier analysis showed that decreased RV ejection fraction (EF) was associated with MACE (P < 0.001) and receiver operating characteristics curve (ROC) analysis indicated good predictive performance of RV EF for MACE (area under the ROC = 0.834). RV EF operated independently of LV EF or LGE extent for predicting MACE. In addition, the presence of LGE in RV was independently associated with MACE (P = 0.011), and a combined analysis of RV EF and RV LGE showed better risk stratification for MACE (P < 0.001). CONCLUSIONS: Both RV EF and LGE were independently associated with MACE and enhanced risk stratification in patients with suspected CS. CMR may be a useful tool for detecting myocardial function and fibrosis in both the LV and RV.
  • 心尖部肥大型心筋症が臨床転帰へ及ぼす影響 心臓MRI所見からの洞察(Impact of Apical Hypertrophic Cardiomyopathy on Clinical Outcomes: Insights from Cardiac Magnetic Resonance Imaging)
    中村 貴; 岩永 善高; 奥根 真楠; 筧 和剛; 河村 尚幸; 栗田 隆志
    日本循環器学会学術集会抄録集 84回 OJ2 - 4 2020年07月
  • 心臓MRI/18F-FDG PETの融合画像による心臓サルコイドーシスの活動性評価(Fusion Imaging of Cardiac Magnetic Resonance/18F-fluorodeoxyglcose Positron Emission Tomography for Assessing Active Cardiac Sarcoidosis)
    副島 奈央子; 安田 昌和; 鍵岡 賛典; 奥根 真楠; 筧 和剛; 河村 尚幸; 栗田 隆志; 岩永 善高
    日本循環器学会学術集会抄録集 84回 PJ14 - 4 2020年07月
  • Takayuki Kawamura; Masakazu Yasuda; Mana Okune; Kazuyoshi Kakehi; Yoshinori Kagioka; Takashi Nakamura; Shunichi Miyazaki; Yoshitaka Iwanaga
    The Canadian journal of cardiology 36 4 518 - 526 2020年04月 
    BACKGROUND: The clinical significance of left ventricular (LV) trabeculation remains unknown in cardiomyopathies. B-Type natriuretic peptide (BNP) strongly reflects LV end-diastolic wall stress and is a useful prognostic marker of cardiovascular diseases. The enhanced identification of LV trabeculae (T) with the use of cardiac magnetic resonance and the evaluation of its relationship with BNP may elucidate the biologic significance and clinical impact of trabeculation in patients with nonischemic cardiomyopathy (NICM). METHODS: The LV volume and mass of 515 patients with NICM and 36 control subjects were analyzed with the use of a steady-state free precession sequence, and individual T mass was planimetred. Major adverse cardiac events (MACE) were assessed. RESULTS: T mass index correlated with LV end-diastolic volume index (EDVI), LV mass index, and papillary muscle mass index (all P < 0.001). Also, T mass index was positively correlated with BNP level (R = 0.381; P < 0.001) and was an independent determinant of BNP after adjusting for age, sex, body mass index (BMI), etiology, LV ejection fraction, and LV EDVI (P < 0.001). Kaplan-Meier analysis during a median follow-up of 17.3 months showed that higher T mass index and increased BNP level correlated with MACE. On multivariate analysis, T mass index (P = 0.031) and BNP (P < 0.001) remained associated with poor outcomes when combined with age, sex, BMI, and etiology. CONCLUSIONS: Increased LV trabeculation was associated with LV dysfunction/remodelling and impaired outcomes in NICM of various etiologies. This may support the biologic significance of LV trabeculation and could be attributed to its association with BNP through LV wall stress.
  • 心房頻拍に対して経大動脈アプローチのカテーテルアブレーション中に急性心筋梗塞を発症した1例
    筧 和剛; 上野 雅史; 山田 信広; 船内 陽平; 永野 兼也; 河村 尚幸; 丸山 将広; 安田 昌和; 山治 憲司; 岩永 善高; 栗田 隆志
    日本冠疾患学会誌 Suppl.2019 171 - 171 (NPO)日本冠疾患学会 2019年12月
  • 台風21号による関西国際空港閉鎖、連絡橋タンカー船衝突事故時に発症した急性肺血栓塞栓症の一例
    船内 陽平; 山治 憲司; 河村 尚幸; 渡邉 平太郎; 高瀬 徹; 上野 雅史; 平野 豊; 岩永 善高; 栗田 隆志
    日本心臓病学会学術集会抄録 67回 P - 083 (一社)日本心臓病学会 2019年09月
  • Kawamura T; Iwanaga Y; Nakamura T; Yasuda M; Kurita T; Miyazaki S
    Internal medicine (Tokyo, Japan) 58 14 2041 - 2044 2019年07月 [査読有り]
  • 心臓MRIによる三尖弁輪収縮期移動距離(TAPSE)は肥大型心筋症患者における予後マーカーのひとつである(Cardiac MRI-derived TAPSE is One of Prognostic Markers in Patients with Hypertrophic Cardiomyopathy)
    中村 貴; 岩永 善高; 筧 和剛; 河村 尚幸; 鍵岡 賛典; 奥根 真楠; 宮崎 俊一
    日本循環器学会学術集会抄録集 83回 PJ118 - 7 2019年03月
  • DES留置後早期に3剤併用抗血栓療法を減量しステント血栓症を来した一例
    松浦 剛郎; 渡邉 平太郎; 河村 尚幸; 高瀬 徹; 上野 雅史; 岩永 善高; 宮崎 俊一
    日本冠疾患学会雑誌 Suppl. 161 - 161 (NPO)日本冠疾患学会 2018年11月
  • Yasuda M; Iwanaga Y; Kawamura T; Nakamura T; De Rosa S; Indolfi C; Miyazaki S
    Medicine 97 35 e11938  2018年08月 [査読有り]
  • Critical Hand IschemiaのCTO病変に対して血管内視鏡を施行した1例
    鍵岡 賛典; 山治 憲司; 藤田 晃輔; 河村 尚幸; 上野 雅史; 生田 新一郎; 小夫家 和宏; 岩永 善高; 宮崎 俊一
    心臓血管内視鏡 3 Suppl. s60 - s60 日本心臓血管内視鏡学会 2017年11月
  • 心サルコイドーシスの脚ブロックおよびQRS分裂がもつ臨床的重要性(Clinical Significance of Bundle Branch Block and Fragmented QRS in Cardiac Sarcoidosis)
    丸山 将広; 岩永 善高; 鍵岡 賛典; 藤田 晃輔; 河村 尚幸; 中村 貴; 安田 昌和; 栗田 隆志; 宮崎 俊一
    日本循環器学会学術集会抄録集 81回 PJ - 158 2017年03月
  • Masakazu Yasuda; Yoshitaka Iwanaga; Takao Kato; Toshiaki Izumi; Yasutaka Inuzuka; Takashi Nakamura; Yuki Miyaji; Takayuki Kawamura; Shigeru Ikeguchi; Moriaki Inoko; Takashi Kurita; Shunichi Miyazaki
    Open Heart 3 2 e000437  2016年07月 [査読有り]
     
    Background The presence of myocardial fibrosis by cardiac MRI has prognostic value in cardiac sarcoidosis, and localisation may be equally relevant to clinical outcomes. Objective We aimed to analyse cardiac damage and function in detail and explore the relationship with clinical outcomes in patients with cardiac sarcoidosis using cardiac MRI. Methods We included 81 consecutive patients with cardiac sarcoidosis undergoing cardiac MR. Left ventricular mass and fibrosis mass were calculated, and localisation was analysed using a 17-segment model. Participants underwent follow-up through 2015, and the development of major adverse cardiac events including ventricular tachyarrhythmias was recorded. Results Increased left ventricular fibrosis mass was associated with increased prevalence of ventricular tachyarrhythmias (p< 0.001). When localisation was defined as the sum of late gadolinium enhancement in the left ventricular basal anterior and basal anteroseptal areas, or the right ventricular area, it was associated with ventricular tachyarrhythmias (p< 0.001). Kaplan-Meier analysis during a median follow-up of 22.1â €..months showed that both the mass and localisation groupings for fibrosis were significantly associated with major adverse cardiac events or ventricular tachyarrhythmias and that when combined, the risk stratification was better than for each variable alone (p< 0.001, respectively). By Cox-proportional hazard risk analysis, the localisation grouping was an independent predictor for the both. Conclusions In patients with cardiac sarcoidosis, both fibrosis mass and its localisation to the basal anterior/anteroseptal left ventricle, or right ventricle was associated with the development of major adverse cardiac events or ventricular tachyarrhythmias. Cardiac MR with late gadolinium enhancement may be useful for improving risk stratification in patients with cardiac sarcoidosis.
  • Takashi Nakamura; Yoshitaka Iwanaga; Masakazu Yasuda; Takayuki Kawamura; Yuki Miyaji; Hanako Morooka; Shunichi Miyazaki
    INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 32 4 613 - 620 2016年04月 [査読有り]
     
    Myocardial fibrosis is frequently observed and may be associated with the prognosis in patients with hypertrophic cardiomyopathy (HCM); however, the clinical pathophysiological features, particularly in terms of fibrosis, of hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. This study aimed to determine a role of local fibrosis in HOCM using cardiac magnetic resonance (CMR). 108 consecutive HCM patients underwent CMR. HOCM was defined as a left ventricular outflow tract (LVOT) pressure gradient a parts per thousand yen30 mmHg at rest. Myocardial mass and fibrosis mass by late gadolinium-enhancement CMR (LGE-CMR) were calculated and the distribution/pattern was analyzed using the AHA 17-segment model. LV ejection fraction (LVEF) was significantly higher in patients with HOCM (n = 19) than in those with nonobstructive HCM (n = 89) (P < 0.05). Both total myocardial and fibrosis masses in LV were similar in the two groups (P = 0.385 and P = 0.859, respectively). However, fibrosis in the basal septum was significantly less frequent in the HOCM group than in the nonobstructive HCM group (P < 0.01). The LVOT pressure gradient was significantly higher in the basal-septal non-fibrosis group than in the fibrosis group (23.6 +/- A 37.3 vs. 4.8 +/- A 11.4 mmHg, P < 0.01). Multivariate analysis revealed that basal-septal fibrosis was an independent negative predictor of LVOT obstruction in addition to the local wall thickness and LVEF as positive predictors in HCM patients. In conclusion, a significant association was observed between LVOT obstruction and basal septal fibrosis by LGE-CMR in HCM patients. In addition to negative impact of basal-septal fibrosis, basal-septal hypertrophy and preserved global LV contractility may be associated with the pathophysiological features of LVOT obstruction.
  • 非虚血性心筋症におけるICD留置後予後の差異
    河村 尚幸; 岩永 善高; 宮地 佑希; 安田 昌和; 中村 貴; 安岡 良文; 元木 康一郎; 栗田 隆志; 宮崎 俊一
    日本内科学会雑誌 105 臨増 159 - 159 (一社)日本内科学会 2016年02月
  • Yuki Miyaji; Yoshitaka Iwanaga; Takashi Nakamura; Masakazu Yasuda; Takayuki Kawamura; Shunichi Miyazaki
    INTERNAL MEDICINE 55 10 1261 - 1268 2016年 [査読有り]
     
    Objective Increased left ventricular mass (LVM) and LV fibrosis mass (LVFM) are characteristics of hypertrophic cardiomyopathy (HCM). Additionally, a substantial increase in the plasma B-type natriuretic peptide (BNP) level is observed. Therefore, we investigated the interrelationship and clinical significances of these parameters in a HCM cohort that underwent cardiac MRI (CMR). Methods Patients with HCM (n=109) receiving regular outpatient treatment underwent CMR and follow-up through 2015 from CMR examinations. The clinical outcome measures were all-cause mortality, admission for worsening heart failure, and ventricular tachycardia/fibrillation. Results The baseline body mass index (BMI), LV outflow tract (LVOT) obstruction, New York Heart Association (NYHA) class, and increased left atrial dimension (LAD) index were associated with the plasma BNP level. In the CMR analysis, LVM and LVFM indices significantly correlated with the BNP level (r=0.422 and 0.368, respectively), which were independent determinants according to a multivariate analysis (p=0.009 and 0.023, respectively). A Kaplan-Meier analysis during a median follow-up of 19.4 months showed that the baseline LVM or LVFM index was not associated with the clinical outcomes. However, the baseline BNP level was significantly associated with them (p<0.001). In addition, a multivariate Cox proportional hazard analysis showed that plasma BNP was an independent predictor for the clinical outcomes after adjusting for age, sex, LVM, and LVFM. Conclusion The LVM and LVFM are determinants of the BNP level independent of the BMI, LVOT obstruction, LAD, and NYHA class in patients with HCM. However, plasma BNP may be a more sensitive integrated-marker for the clinical outcomes than LVM or LVFM.

講演・口頭発表等

  • Impact of papillary muscle hypertrophy in hypertrophic cardiomyopathy: insights from cardiac magnetic resonance analysis  [通常講演]
    河村 尚幸; 岩永善高; 安田昌和; 中村貴; 宮崎俊一
    ESC Congress 2016年08月 ポスター発表
  • 非虚血性心筋症のICD留置後の予後の差異  [通常講演]
    河村尚幸; 岩永善高; 宮地佑希; 安田昌和; 中村貴; 安岡良文; 元木康一郎; 栗田隆志; 宮崎俊一
    第113回日本内科学会総会 2016年04月 ポスター発表
  • Diagnostic and prognostic values of serumangiotensin-converting enzyme level in cardiac sarcoidosis  [通常講演]
    河村尚幸; 岩永善高; 安田昌和; 中村貴; 宮崎俊一
    第80回日本循環器学会学術集会 2016年03月 ポスター発表
  • 大動脈弁狭窄症、肥大型心筋症にて失神を来たした１例  [通常講演]
    河村 尚幸; 岩永 善高; 中村 貴; 平野 豊; 栗田 隆志; 宮崎 俊一
    第63回心臓病学会学術集会 2015年09月 ポスター発表
  • Clinical significance of measuring serum angiotensin-converting enzyme in cardiac sarcoidosis: analysis by cardiac MRI and FDG-PET  [通常講演]
    河村尚幸; 岩永善高; 安田昌和; 中村貴; 宮崎俊一
    第79回日本循環器学会学術集会 2015年03月 ポスター発表
  • 肝細胞癌に対するラジオ波施行後に生じた、たこつぼ型心筋障害の１例  [通常講演]
    河村 尚幸; 池田 智之; 上野 雅史; 藤田 晃輔; 八木 英次郎; 磯野 員理; 生田 新一郎; 平野 豊; 宮崎 俊一
    第21回 日本心血管インターベンション治療学会近畿地方会 2013年10月 豊中市 第21回 日本心血管インターベンション治療学会近畿地方会
  • アイゼンメンジャー症候群に伴う肺高血圧症に対して肺血管拡張薬を使用した３症例  [通常講演]
    河村 尚幸; 谷口 貢; 植木博之; 平野 豊; 宮崎 俊一
    第61回 日本心臓病学会学術集会 2013年09月 熊本市 第61回 日本心臓病学会学術集会
  • 冠動脈瘤内血栓により心筋梗塞を発症した1例  [通常講演]
    八木 英次郎; 磯野 員理; 河村 尚幸; 渡邉 平太郎; 中村 貴; 上野 雅史; 生田 新一郎; 山本 裕美; 谷口 貢; 岩永 善高; 宮崎 俊一
    第115回 日本循環器学会近畿地方会 2013年06月 京都市 第115回 日本循環器学会近畿地方会
  • 僧房弁閉鎖不全の原因同定に苦慮した1例  [通常講演]
    長束 一紘; 山本 裕美; 河村 尚幸; 中村 貴; 岩永 善高; 宮崎 俊一
    第115回 日本循環器学会近畿地方会 2013年06月 第115回 日本循環器学会近畿地方会
  • 学生・初期研修医セッション 陳旧性心筋梗塞の加療中に完全房室ブロックが出現しMRI・PET－CTにて心サルコイドーシスと診断された1例  [通常講演]
    田中 寛樹; 安田 昌和; 八木 英次郎; 河村 尚幸; 中村 貴; 岩永 善高; 宮崎 俊一
    第114回 日本循環器学会近畿地方会 2012年12月 大阪国際会議場 第114回 日本循環器学会近畿地方会

MISC

その他のリンク

researchmap


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.