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NAKAO Kikuyo

    Kindai University Hospital　Research assistant
Last Updated :2024/04/25

Researcher Information

Degree

  • ph.D（2013 Kindai University）

J-Global ID

Research Areas

  • Other / Other

Published Papers

  • Murata Kazuya; Nakao Kikuyo; Moriyama Kenzo; Fujita Takanori; Matsuda Hideaki
    J. Trad. Med. Medical and Pharmaceutical Society for WAKAN-YAKU 30 (3) 140 - 144 1880-1447 2013 [Refereed]
     
    A screening of extracts from seven Lamiaceae plants for their effects on xanthine oxidase, a key enzyme in the biosynthesis of uric acid, was performed. Among the plants tested, peppermint (dried leaves of Mentha piperita) showed the potent inhibitory activity. Inhibitory activity guided purification of the active constituent led us to obtain pratensein and apigenin. This is the first report on the inhibitory activity of pratensein on xanthine oxidase.
  • Murata Kazuya; Tsukioka Yasuyuki; Nakao Kikuyo; Moriyama Kenzo; Samukawa Keiichi; Namba Kensuke; Matsuda Hideaki
    J. Trad. Med. Medical and Pharmaceutical Society for WAKAN-YAKU 29 (4) 169 - 178 1880-1447 2012 [Refereed]
     
    The effect of 70% methanolic extract of Red Ginseng (Panax ginseng C. A. MEYER, RG-ext) was investigated on blood fluidity in rats. Evaluation of blood fluidity was carried out by measuring whole blood passage time using a micro channel array flow analyzer (MC-FAN), polybrene-induced erythrocyte aggregation (PEA), and the euglobulin lysis time (ELT). RG-ext inhibited the elongation of the passage time caused by cold stress (5°C), whereas White Ginseng extract (WG-ext) showed no effect. In addition, RG-ext showed inhibition of PEA. The aggregation inhibitory activity of RG-ext was stronger than that of WG-ext. These data indicated that effects of RG-ext on blood fluidity are superior to those of WG-ext. Successive oral administration of RG-ext (50 and 200 mg/kg, p.o.) to adjuvant-induced arthritis model rats inhibited the elongations of both the whole blood passage time and ELT caused by arthritis, although RG-ext showed no effect on right hind paw swelling. In order to identify active constituents, the effects of several Ginseng saponins [ginsenoside-Ro, -Rb1, -Rg1 and 20(S)-ginsenoside-Rg3 [20(S)-Rg3]] in Red Ginseng on the elongation of whole blood passage time in low temperature-treated rat blood and PEA were examined. Among these, 20(S)-Rg3, a saponin characteristic of Red Ginseng, showed the most potent inhibitory activity on elongation of whole blood passage time and showed concentration-dependent inhibition of PEA. Therefore, part of the effect of Red Ginseng on improving blood fluidity may be attributable to 20(S)-Rg3.
  • Nakao Kikuyo; Murata Kazuya; Itoh Kimihisa; Hanamoto Yuko; Masuda Megumi; Moriyama Kenzo; Shintani Takahiro; Matsuda Hideaki
    Journal of Traditional Medicines Medical and Pharmaceutical Society for WAKAN-YAKU 28 (1) 10 - 15 1880-1447 2011 [Refereed]
     
    In our search for novel materials possessing anti-hyperuricemic effects, we examined immature Citrus unshiu fruit. Extracts of immature C. unshiu fruit showed moderate anti-hyperuricemic effects in a hyperuricemic model; the extract reduced increased serum urate level by 36% at 500 mg/kg, p.o. The extract did not show significant xanthine oxidase inhibitory activity, but the metabolite of the main flavanone glycoside in the fruit, hesperetin, showed potent anti-hyperuricemic effects; hesperetin reduced increased serum urate level by 44% at 200 mg/kg, p.o. Furthermore, hesperetin showed dose-dependent xanthine oxidase inhibitory activity of 52% at 200 μM. Thus, the anti-hyperuricemic effects of immature C. unshiu may be attributed to hesperetin, a metabolite of hesperidin via xanthine oxidase inhibition.
  • Kikuyo Nakao; Kenzo Moriyama; Kazuya Murata; Hideaki Matsuda; Tadato Tani
    Yakushigaku zasshi 46 (2) 91 - 101 0285-2314 2011 [Refereed]
     
    Rates of gouty arthritis with hyperuricemia have increased recently as it has become a lifestyle-related disease. We reviewed historical treatments for pain due to gouty arthritis in traditional Chinese medical books, with special interest in pathological causes, including dietary and drinking habits, as well as the frequency of crude drugs used in historical prescriptions. From the present historical survey, we showed that six traditional terms may be equivalent to modern gouty arthritis and that the "Manbyokaishun," a formulary edited in the 16th century in China, included medical information for gouty arthritis. Furthermore, the 46 prescriptions, including Sokeikakketsuto, mentioned in the "Manbyokaishun," were selected as likely treatments for gouty arthritis. The most common crude drugs in the 46 prescriptions were aconite root, angelica root, cinnamon bark, peony root and saposhnikovia root. The inhibitory activity of these crude drugs extracts against xanthine oxidase was investigated. Angelica root and saposhnikovia root showed more potent inhibitory activity (20% at 250 microg/mL) than aconite root (16%), notopterygium rhizome (15%) and cinnamon bark (12%).
  • Kikuyo Nakao; Kazuya Murata; Takahiro Deguchi; Kimihisa Itoh; Takanori Fujita; Masayuki Higashino; Yuri Yoshioka; Shin-Ichi Matsumura; Rika Tanaka; Tetsuro Shinada; Yasufumi Ohfune; Hideaki Matsuda
    Biological & pharmaceutical bulletin 34 (7) 1143 - 6 2011 [Refereed]
     
    Kaempferia parviflora (KP), a Zingiberaceae plant, is used as a folk medicine in Thailand for the treatment of various symptoms, including general pains, colic gastrointestinal disorders, and male impotence. In this study, the inhibitory activities of KP against xanthine oxidase (XOD) were investigated. The extract of KP rhizomes showed more potent inhibitory activity (38% at 500 µg/ml) than those of the other Zingiberaceae plants tested. Ten methoxyflavones were isolated from the KP extract as the major chemical components and their chemical structures were elucidated by X-ray crystallography. The structurally confirmed methoxyflavones were subjected to the XOD inhibitory test. Among them, 3,5,7,4',5'-pentamethoxyflavone and 3',4',5,7-tetramethoxyflavone showed inhibitory activities (IC(50) of 0.9 and >4 mM, respectively) and their modes of inhibition are clarified as competitive/non-competitive mixed type. To the best of our knowledge, this is the first report to present the inhibitory activities of KP, 3,5,7,4',5'-pentamethoxyflavone and 3',4',5,7-tetramethoxyflavone against XOD.
  • Kazuya Murata; Kikuyo Nakao; Noriko Hirata; Kensuke Namba; Takao Nomi; Yoshihisa Kitamura; Kenzo Moriyama; Takahiro Shintani; Munekazu Iinuma; Hideaki Matsuda
    Journal of Natural Medicines Springer Science and Business Media LLC 63 (3) 355 - 359 1340-3443 2009/07 [Refereed]
  • TAHARA Eiichi; SHINTANI Takahiro; MORIYAMA Kenzo; NAKAO Kikuyo; TSUKIOKA Yasuyuki; NIIZAWA Atsushi; NINOMIYA Hiroyuki; TAKAYA Yutaka
    Japanese Journal of Oriental Medicine The Japan Society for Oriental Medicine 57 (5) 639 - 643 0287-4857 2006/09 [Refereed]
     
    We analyzed the differences between responder and non-responder groups using Choyoto for hand eczema. In 7 cases the drug was effective, and in 6 cases it was not. Most patients in the effective group had white-complexioned skin, and the eczema tended to localize on the hands. In contrast, most patients in the noneffective group had with sleep difficulties and/or a smoking habit. In addition, they showed marked symptoms of Oketsu such as dark red gingiva, indicating that many of the non-effective hand eczema cases had elevated Oketsu scores. It was shown that objective and subjective symptoms could be indicators for the choosing of Choyoto for hand eczema treatment.
  • Yutaka Takaya; Takahiro Shintani; Eiichi Tahara; Yasuyuki Tsukioka; Kenzo Moriyama; Kikuyo Nakao; Hideaki Matsuda; Atsushi Niizawa; Hiroyuki Ninomiya; Katsutoshi Terasawa
    Journal of Traditional Medicines 23 (4) 147 - 150 1881-3747 2006 [Refereed]
     
    Increasing evidence suggests that remnant-like lipoprotein particles cholesterol (RLP-C) is an independent cardiovascular disease (CVD) risk factor. High levels of RLP-C exhibit findings similar to those of “oketsu” syndrome on blood rheology studies and scanning electron micrographs. We measured levels of RLP-C in plasma samples and “oketsu” scores obtained in 199 randomly selected subjects. The coefficient of correlation between levels of RLP-C and “oketsu” score was highly significant (r=0.581, P< 0.0001). This finding suggests that presence of excess RLP-C in the blood resembles closely “oketsu” syndrome which we have shown to be an independent risk factor for CVD. © 2006, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.

Conference Activities & Talks

  • 未熟温州ミカン果実の血清尿酸値低下作用に関する研究  [Not invited]
    中尾 紀久世; 松田 秀秋; 森山 健三; 新谷 卓弘; 増田 めぐみ; 伊藤 仁久; 花本 祐子; 古川 加純; 村田 和也; 飯沼 宗和
    日本生薬学会第56回年会  2009  京都  日本生薬学会第56回年会
  • コショウ科キンマ（Piper betle L.）葉のキサンチンオキシダーゼ阻害作用に関する研究  [Not invited]
    松田 秀秋; 平田 規子; 野口 秀人; 難波 健輔; 劉 鵬; 中尾 紀久世; 森山 健三; 新谷 卓弘; 能味 堂郎; 飯沼 宗和
    日本薬学会第128年会  2008  横浜  日本薬学会第128年会
  • 和歌山県産ブドウサンショウの生理活性成分  [Not invited]
    松田 秀秋; 難波 健輔; 中尾 紀久世; 森山 健三; 新谷 卓弘; 得永 雅士; 前島 義郎
    第25回和漢医薬学会学術大会  2008  大阪  第25回和漢医薬学会学術大会
  • 薬用人参の血液流動性亢進に関する研究  [Not invited]
    月岡 康行; 松田 秀秋; 中尾 紀久世; 森山 健三; 新谷 卓弘; 竹下 文章; 稲葉 一訓; 寒川 慶一
    日本生薬学会第55回年会  2008  長崎  日本生薬学会第55回年会
  • 新健康素材・山椒  [Not invited]
    中尾 紀久世
    KAMPO EYES シンポジウム 薬局分科会  2005/10  大阪  KAMPO EYES シンポジウム 薬局分科会
  • 加附子の功罪について  [Not invited]
    新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 吉川 雅之; 月岡 康行; 新澤 敦; 二宮 裕幸; 髙屋 豊; 平崎 能郎; 山本 篤
    平成17年度日本東洋医学会関西支部例会  2005/10  奈良  平成17年度日本東洋医学会関西支部例会
  • 症状軽快にもかかわらず、肝機能障害を認めた眼輪部皮膚炎の一例  [Not invited]
    田原 英一; 新谷 卓弘; 森山 健三; 中尾 紀久世; 月岡 康行; 吉川 雅之; 山本 篤; 平崎 能郎; 髙屋 豊; 新澤 敦; 二宮 裕幸
    平成17年度日本東洋医学会関西支部例会  2005/10  奈良  平成17年度日本東洋医学会関西支部例会
  • 大柴胡湯長期投与により間質性肺炎の合併を生じた一例  [Not invited]
    髙屋 豊; 新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 吉川 雅之; 月岡 康行; 新澤 敦; 二宮 裕幸; 平崎 能郎; 山本 篤
    平成17年度日本東洋医学会関西支部例会  2005/10  奈良  平成17年度日本東洋医学会関西支部例会
  • アトピー性皮膚炎における青森ヒバ入浴オイルの使用経験  [Not invited]
    田原 英一; 新谷 卓弘; 森山 健三; 中尾 紀久世; 吉川雅之; 月岡康行; 松田秀秋; 髙屋豊; 新沢敦; 二宮裕幸
    第22回和漢医薬学大会  2005/08  東京  第22回和漢医薬学大会
  • 難治性GERDにおける氣の失調と胃噴門部の関連について  [Not invited]
    髙屋豊; 田原 英一; 新谷 卓弘; 中尾 紀久世; 森山 健三; 月岡康行; 新沢敦; 二宮裕幸; 後藤博三; 寺澤捷年
    第22回和漢医薬学大会  2005/08  東京  第22回和漢医薬学大会
  • 大建中湯が奏効した過敏性腸症候群の1例  [Not invited]
    田原 英一; 新谷 卓弘; 森山 健三; 中尾 紀久世; 久保道德; 新沢敦; 二宮裕幸; 髙屋豊
    第55回日本東洋医学会学術総会  2005/05  富山  第55回日本東洋医学会学術総会
  • ？血のパラメーターとしてのレムナント様リポ蛋白コレステロール（RLP-C）  [Not invited]
    髙屋豊; 田原 英一; 新谷 卓弘; 中尾 紀久世; 森山 健三; 月岡康行; 久保道德; 引網宏彰; 古田一史; 嶋田豊; 後藤博三; 寺澤捷年
    第56回日本東洋医学会学術総会  2005/05  富山  第56回日本東洋医学会学術総会
  • 手湿疹に対する腸癰湯の有効例・無効例の検討  [Not invited]
    田原 英一; 新谷卓弘; 森山 健三; 中尾 紀久世; 久保道德; 高屋豊; 新澤敦; 二宮裕幸; 嶋田豊; 寺澤捷年
    2005
  • 鍼灸治療と漢方薬の併用が奏効したと考えられる不妊症の一例  [Not invited]
    川口 顕; 新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德; 月岡 康行; 村上 純一; 新澤 敦; 二宮 裕幸; 髙屋 豊; 平崎 能郎
    平成16年度日本東洋医学会関西支部例会  2004/10  神戸  平成16年度日本東洋医学会関西支部例会
  • EBウイルス脳炎後の摂食障害に大柴胡湯が有効であった症例  [Not invited]
    髙屋 豊; 新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德; 新澤 敦; 二宮 裕幸; 平崎 能郎
    平成16年度日本東洋医学会関西支部例会  2004/10  神戸  平成16年度日本東洋医学会関西支部例会
  • 清心蓮子飲により「七割の生き方」が可能となった双極性障害の一例  [Not invited]
    新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德; 新澤 敦; 二宮 裕幸; 髙屋 豊; 平崎 能郎
    平成16年度日本東洋医学会関西支部例会  2004/10  神戸  平成16年度日本東洋医学会関西支部例会
  • 氣の失調と胃食道逆流症の検討  [Not invited]
    新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德; 松田 秀秋; 髙屋 豊; 新澤 敦; 二宮 裕幸
    第21回和漢医薬学会大会  2004/08  富山  第21回和漢医薬学会大会
  • 胃食道逆流症の治療反応の差異からみた氣の失調の意味づけ  [Not invited]
    髙屋 豊; 新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德; 松田 秀秋; 月岡 康行; 新澤 敦; 二宮 裕幸
    第21回和漢医薬学会大会  2004/08  富山  第21回和漢医薬学会大会
  • 胃食道逆流症に対する日本語版GSRSと氣スコアの検討  [Not invited]
    髙屋 豊; 新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德; 松田 秀秋; 新澤 敦; 二宮 裕幸
    第21回和漢医薬学会大会  2004/08  富山  第21回和漢医薬学会大会
  • 閉塞性化膿性胆管炎の急性期治療に茵陳蒿湯エキス製剤等の併用が有効であった三症例  [Not invited]
    髙屋 豊; 新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德
    第55回日本東洋医学会学術総会  2004/06  横浜  第55回日本東洋医学会学術総会
  • 氣虚と心理状態の検討  [Not invited]
    新谷 卓弘; 田原 英一; 森山 健三; 中尾 紀久世; 久保 道德; 髙屋 豊
    第55回日本東洋医学会学術総会  2004/06  横浜  第55回日本東洋医学会学術総会
  • The Effects of Containing Rhemaniae Radix on Hematological with Behcet's disease Findings  [Not invited]
    森山 健三; 中尾 紀久世; 田原 英一; 新谷 卓弘; 久保 道徳; 二宮 裕幸; 新沢 敦; 永山 紀子; 高屋 豊
    第54回日本東洋医学会学術総会  2003/05  福岡市  第54回日本東洋医学会学術総会
     
    他院から処方された鉄含有量の高い生薬である地黄の長期連用によると見られるヘモクロマトーシスの症例を示し，西洋医学的診断を取り入れながら処方運用を行う事が必要であることを報告した．

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