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TAKEUCHI Yuichi

    Department of Pharmacy　Professor
Last Updated :2024/05/19

Researcher Information

Degree

  • Ph.D. (Science)（2010/03 The Graduate University for Advanced Studies）

URL

Research funding number

  • 70588384

ORCID ID

J-Global ID

Profile

  • Yuichi Takeuchi earned his BSc and MS from Nagoya City University in Japan, where he studied analgesic mechanisms of anti-epileptic drugs. He received his PhD in neurophysiology from the National Institute of Physiological Sciences in Japan 2010, where he studied remodeling of the somatosensory pathway of rodents after peripheral nerve injury using in vitro and in vivo electrophysiological techniques. He then worked in Tokyo Women's Medical University in Japan as a faculty. After that, he worked in University of Szeged in Hungary, where he developed a real-time closed-loop intervention of epileptic seizures. His research is currently focused on real-time closed-loop interventions of neuropsychiatric disorders.


    curriculum vitae  Takeuchi lab


    A postdoctoral position and student positions are available now. Let's enjoy science together!


    open postdoctoral position  open student position 


     

Research Interests

  • Mental disorders   Biological markers   Simulation   Basal forebrain   Deep Brain Stimulation   Electroencephalogram   Oscillation   Real-time processing   Machine learning   Prefrontal cortex   Decision making   Limbic system   Ultrasound   Neurological disorders   Optogenetics   Epilepsy   Non-Invasive Brain Stimulation   Electrophysiology   Neural circuit   Comprehensive Brain Science Network   

Research Areas

  • Life sciences / Neurology
  • Life sciences / Psychiatry
  • Life sciences / Neuroscience - general
  • Life sciences / Physiology

Academic & Professional Experience

  • 2024/04 - Today  Hokkaido UniversityFaculty of Pharmaceutical SciencesVisiting Professor
  • 2024/04 - Today  Kindai UniversityFaculty of Pharmacy Department of PharmacyProfessor
  • 2022/01 - 2024/03  National Institutes for Quantum and Radiological Science and TechnologyVisiting Research Fellow
  • 2021/08 - 2024/03  Hokkaido UniversityFaculty of Pharmaceutical SciencesAssociate Professor
  • 2018/04 - 2022/03  Nagoya City UniversityGraduate School of Pharmaceutical SciencesResearch Fellow
  • 2020/09 - 2021/07  Osaka City UniversityGraduate School of MedicineSpecially-Appointed Lecturer
  • 2015/09 - 2020/08  Hungarian Medical UniversitiesVisiting Lecturer
  • 2015/09 - 2020/08  University of SzegedFaculty of MedicineResearch Assistant Professor
  • 2016/01 - 2016/12  Uehara Memorial FoundationResearch Fellow
  • 2010/04 - 2015/08  Tokyo Women's Medical UniversityDepartment of PhysiologyAssistant Professor
  • 2009/04 - 2010/03  Japan Society for the Promotion of ScienceResearch Fellow
  • 2007/04 - 2008/08  National Institute for Physiological SciencesResearch Assistant

Education

  • 2007/04 - 2010/03  The Graduate University for Advanced Studies  School of Life Science  Department of Physiological Sciences
  • 2005/04 - 2007/03  Nagoya City University  Graduate School of Pharmaceutical Sciences  医療機能薬学専攻
  • 2001/04 - 2005/03  Nagoya City University  Faculty of Pharmaceutical Sciences  製薬学科

Association Memberships

  • The Pharmaceutical Society of Japan   Asia-Pacific Neural Network Society   JAPANESE NEURAL NETWORK SOCIETY   Society for Neuroscience   PHYSIOLOGICAL SOCIETY OF JAPAN   THE JAPAN NEUROSCIENCE SOCIETY   THE JAPANESE PHARMACOLOGICAL SOCIETY   

Published Papers

  • Rodrigo Ordoñez Sierra; Lizeth Katherine Pedraza; Lívia Barcsai; Andrea Pejin; Qun Li; Gábor Kozák; Yuichi Takeuchi; Anett J. Nagy; Magor L. Lőrincz; Orrin Devinsky; György Buzsáki; Antal Berényi
    Nature Communications Springer Science and Business Media LLC 14 (1) 3972  2023/07 [Refereed]
     
    Dysregulated fear reactions can result from maladaptive processing of trauma-related memories. In post-traumatic stress disorder (PTSD) and other psychiatric disorders, dysfunctional extinction learning prevents discretization of trauma-related memory engrams and generalizes fear responses. Although PTSD may be viewed as a memory-based disorder, no approved treatments target pathological fear memory processing. Hippocampal sharp wave-ripples (SWRs) and concurrent neocortical oscillations are scaffolds to consolidate contextual memory, but their role during fear processing remains poorly understood. Here, we show that closed-loop, SWR triggered neuromodulation of the medial forebrain bundle (MFB) can enhance fear extinction consolidation in male rats. The modified fear memories became resistant to induced recall (i.e., ‘renewal’ and ‘reinstatement’) and did not reemerge spontaneously. These effects were mediated by D2 receptor signaling-induced synaptic remodeling in the basolateral amygdala. Our results demonstrate that SWR-triggered closed-loop stimulation of the MFB reward system enhances extinction of fearful memories and reducing fear expression across different contexts and preventing excessive and persistent fear responses. These findings highlight the potential of neuromodulation to augment extinction learning and provide a new avenue to develop treatments for anxiety disorders.
  • Li Q; Takeuchi Y; Wang J; Gellért L; Barcsai L; Pedraza LK; Nagy AJ; Kozák G; Nakai S; Kato S; Kobayashi K; Ohsawa M; Horváth G; Kékesi G; Lőrincz ML; Devinsky O; Buzsáki G; Berényi A
    Neuron Cell Press 111 2065 - 2075 2023/07 [Refereed]
     
    Although the etiology of major depressive disorder remains poorly understood, reduced gamma oscillations is an emerging biomarker. Olfactory bulbectomy, an established model of depression that reduces limbic gamma oscillations, suffers from non-specific effects of structural damage. Here, we show that transient functional suppression of olfactory bulb neurons or their piriform cortex efferents decreased gamma oscillation power in limbic areas and induced depression-like behaviors in rodents. Enhancing transmission of gamma oscillations from olfactory bulb to limbic structures by closed-loop electrical neuromodulation alleviated these behaviors. By contrast, silencing gamma transmission by anti-phase closed-loop stimulation strengthened depression-like behaviors in naive animals. These induced behaviors were neutralized by ketamine treatment that restored limbic gamma power. Taken together, our results reveal a causal link between limbic gamma oscillations and depression-like behaviors in rodents. Interfering with these endogenous rhythms can affect behaviors in rodent models of depression, suggesting that restoring gamma oscillations may alleviate depressive symptoms.
  • Takeuchi Y; Nagy AJ; Barcsai L; Li Q; Ohsawa M; Mizuseki K; Berényi A
    Front Neural Circuits Frontiers 15 701080 - 701080 2021/07 [Refereed][Invited]
     
    The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Accumulating evidence points out that the physiological oscillations under septal influence are frequently disrupted or altered in pathological conditions. Therefore, the MS may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies) to restore healthy patterns or erase undesired ones. Recent studies have revealed that the patterned stimulation of the MS alleviates symptoms of epilepsy. We discuss here that stimulus timing is a critical determinant of treatment efficacy on multiple time scales. On-demand stimulation may dramatically reduce side effects by not interfering with normal physiological functions. A precise pattern-matched stimulation through adaptive timing governed by the ongoing oscillations is essential to effectively terminate pathological oscillations. The time-targeted strategy for the MS stimulation may provide an effective way of treating multiple disorders including Alzheimer's disease, anxiety/fear, schizophrenia, and depression, as well as pain.
  • Kathleen C. Robinson; Lajos V. Kem{\'{e } }ny; Gillian L. Fell; Andrea L. Hermann; Jennifer Allouche; Weihua Ding; Ajay Yekkirala; Jennifer J. Hsiao; Mack Y. Su; Nicholas Theodosakis; Gabor Kozak; Yuichi Takeuchi; Shiqian Shen; Antal Berenyi; Jianren Mao; Clifford J. Woolf; David E. Fisher
    Science Advances American Association for the Advancement of Science ({AAAS}) 7 (14) abd1310  2375-2548 2021/04 [Refereed]
     
    In the red-haired background, altered pain thresholds exist and are explained by distinct OPRM1/MC4R signaling.
  • Yuichi Takeuchi; Márk Harangozó; Lizeth Pedraza; Tamás Földi; Gábor Kozák; Qun Li; Antal Berényi
    Brain Oxford University Press (OUP) 114 (3) 885 - 908 0006-8950 2021/01 [Refereed]
     
    Temporal lobe epilepsy with distributed hippocampal seizure foci is often intractable and its secondary generalization might lead to sudden death. Early termination through spatially extensive hippocampal intervention is not feasible directly, because of the large size and irregular shape of the hippocampus. In contrast, the medial septum is a promising target to govern hippocampal oscillations through its divergent connections to both hippocampi. Combining this ‘proxy intervention’ concept and precisely timed stimulation, we report here that closed-loop medial septum electrical stimulation can quickly terminate intrahippocampal seizures and suppress secondary generalization in a rat kindling model. Precise stimulus timing governed by internal seizure rhythms was essential. Cell type-specific stimulation revealed that the precisely timed activation of medial septum GABAergic neurons underlaid the effects. Our concept of time-targeted proxy stimulation for intervening pathological oscillations can be extrapolated to other neurological and psychiatric disorders, and has potential for clinical translation.
  • Yasunaga H; Takagi T; Shinko D; Nakayama Y; Takeuchi Y; Nishikawa A; Loesing A; Ohsawa M; Sekiguchi H
    Jpn J Appl Phys IOP Publishing 60 (1) 016503 - 016503 0021-4922 2020/12 [Refereed]
  • Yasuyuki Nagumo; Yoshifumi Ueta; Hisako Nakayama; Hironobu Osaki; Yuichi Takeuchi; Naofumi Uesaka; Masanobu Kano; Mariko Miyata
    Cell Reports Elsevier BV 31 (12) 107797 - 107797 2211-1247 2020/06 [Refereed]
  • Yuichi Takeuchi; Antal Ber{\'{e } }nyi
    Neuroscience Research Elsevier {BV} 152 87 - 107 0168-0102 2020/03 [Refereed][Invited]
  • Madoka Narushima; Yuki Yagasaki; Yuichi Takeuchi; Atsu Aiba; Mariko Miyata
    PLOS ONE 14 (12) e0226820  2019/12 [Refereed]
  • Niimi Y; Matsumine H; Takeuchi Y; Osaki H; Tsunoda S; Miyata M; Yamato M; Sakurai H
    Microsurgery 39 (1) 70 - 80 2019/01 [Refereed]
     
    PURPOSE: This study investigated the potential of collagen-coated polyglycolic acid (PGA) tube with interpositional jump graft (IPJG) in rat. MATERIALS AND METHODS: A total of 16 Lewis rats were used in this study. Facial nerve paralysis was created by ligating facial nerve trunk with a ligature clip. The rats were divided into 3 groups. Nerve conduit group (n = 6) were treated by IPJG with collagen-coated PGA tubes between the facial nerve trunks and the hypoglossal nerves. Autograft group (n = 6) were treated by IPJG with the greater auricular nerves. As the control group (n = 4), non-treated-model rats with facial nerve paralysis were used. The number of myelinated fibers, fiber diameter, axon diameter, myelin thickness, and g-ratio, were analyzed histologically at 13 weeks after surgery. Compound muscle action potential (CMAP) and retrograde tracing were measured. RESULT: Although the number of myelinated fibers in autograft group (1957 ± 775) had significantly higher than that of nerve conduit group (90 ± 41, P < .05), the nerve conduit group showed the regeneration of myelinated nerve axons. CMAP amplitude values of the autograft (4706 ± 1154 µV) and the nerve conduit groups (4119 ± 1397 µV) were significantly higher than that of the control group (915 ± 789 µV, P < .05). Retrograde tracing confirmed the double innervation of mimetic muscles by the facial and hypoglossal nucleus in both groups. CONCLUSION: This study showed histologically and physiologically the superior effectiveness of performing IPJG with a collagen-coated PGA conduit in a rat model.
  • Nagy, Anett J.; Takeuchi, Yuichi; Berényi, Antal
    PLOS Biology 16 (6) e2004712  2018/06 [Refereed]
  • Mihály Vöröslakos; Yuichi Takeuchi; Kitti Brinyiczki; Tamás Zombori; Azahara Oliva; Antonio Fernández-Ruiz; Gábor Kozák; Zsigmond Tamás Kincses; Béla Iványi; György Buzsáki; Antal Berényi
    Nature Communications 9 483  2018/02 [Refereed]
  • Yuichi Takeuchi; Hironobu Osaki; Hajime Matsumine; Yosuke Niimi; Ryo Sasaki; Mariko Miyata
    MethodsX Elsevier B.V. 5 283 - 298 2215-0161 2018/01 [Refereed]
     
    Compound muscle action potential (CMAP) recording via reconstructed or regenerated motor axons is a critical examination to evaluate newly developed surgical and regeneration techniques. However, there is currently no documentation on technical aspects of CMAP recordings via reconstructed or regenerated facial nerves. We have studied new techniques of plastic surgery and nerve regeneration using a rat facial nerve defect model for years, standardizing an evaluation pipeline using CMAP recordings. Here we describe our CMAP recording procedure in detail as a package including surgical preparation, data acquisition, analysis and troubleshooting. Each resource is available in public repositories and is maintained as a version control system. In addition, we demonstrate that our analytical pipeline can not only be applied to rats, but also mice. Finally, we show that CMAP recordings can be practically combined with other behavioral and anatomical examinations. For example, retrograde motor neuron labeling provides anatomical evidence for physical routes between the facial motor nucleus and its periphery through reconstructed or regenerated facial nerves, in addition to electrophysiological evidence by CMAP recordings from the same animal. • Standardized surgical, recording and analytical procedures for the functional evaluation of reconstructed or regenerated facial nerves of rats, extended to mice.• The functional evaluation can be combined with anatomical evaluations.• The methods described here are maintained in public repositories as version control systems.
  • Yuichi Takeuchi; Hironobu Osaki; Yuki Yagasaki; Yoko Katayama; Mariko Miyata
    eNeuro Society for Neuroscience 4 (2) e0345-16  2373-2822 2017 [Refereed]
     
    Plastic changes in the CNS in response to peripheral sensory nerve injury are a series of complex processes, ranging from local circuit remodeling to somatotopic reorganization. However, the link between circuit remodeling and somatotopic reorganization remains unclear. We have previously reported that transection of the primary whisker sensory nerve causes the abnormal rewiring of lemniscal fibers (sensory afferents) on a neuron in the mouse whisker sensory thalamus (V2 VPM). In the present study, using transgenic mice whose lemniscal fibers originate from the whisker sensory principle trigeminal nucleus (PrV2) are specifically labeled, we identified that the transection induced retraction of PrV2-originating lemniscal fibers and invasion of those not originating from PrV2 in the V2 VPM. This anatomical remodeling with somatotopic reorganization was highly correlated with the rewiring of lemniscal fibers. Origins of the non-PrV2-origin lemniscal fibers in the V2 VPM included the mandibular subregion of trigeminal nuclei and the dorsal column nuclei (DCNs), which normally represent body parts other than whiskers. The transection also resulted in ectopic receptive fields of V2 VPM neurons and extraterritorial pain behavior on the uninjured mandibular region of the face. The anatomical remodeling, emergence of ectopic receptive fields, and extraterritorial pain behavior all concomitantly developed within a week and lasted more than three months after the transection. Our findings, thus, indicate a strong linkage between these plastic changes after peripheral sensory nerve injury, which may provide a neural circuit basis underlying large-scale reorganization of somatotopic representation and abnormal ectopic sensations.
  • Yosuke Niimi; Hajime Matsumine; Yuichi Takeuchi; Ryo Sasaki; Yorikatsu Watanabe; Masayuki Yamato; Mariko Miyata; Hiroyuki Sakurai
    Plastic and Reconstructive Surgery - Global Open Lippincott Williams and Wilkins 3 (6) e416  2169-7574 2015 [Refereed]
     
    Background: Interpositional jump graft (IPJG) is a nerve graft axonally supercharged from the hypoglossal nerve. However, for using the technique, an autologous nerve, which should contain the great auricular and sural nerves, must be obtained. Depending on the donor site, unavoidable issues such as nerve disorders and postoperative scarring may appear. To reduce the issues, in this study, the authors developed an end-to-side neurorrhaphy technique with the recipient nerve and an artificial nerve conduit and investigated the efficacy of an IPJG with an artificial nerve conduit in a rat facial nerve paresis model. Methods: A ligature clip was used to crush the facial nerve trunk, thereby creating a partial facial nerve paresis model. An artificial nerve conduit was then prepared with a 10-mm-long silicone tube containing 10 μL type I collagen and used to create an IPJG between the facial nerve trunk and the hypoglossal nerve (the silicone tube group). Thirteen weeks after the surgery, the outcome was histologically and physiologically compared with conventional IPJG with autograft using the great auricular nerve. Results: Retrograde tracer test confirmed a double innervation by the facial and hypoglossal nerve nuclei. In the autograft and silicone tube groups, the regeneration of myelinated axons was observed. Conclusion: In this study, the authors successfully developed an end-to-side neurorrhaphy technique with the recipient nerve and an artificial nerve conduit, and revealed that an IPJG in the conduit was effective in the rat facial nerve paresis model.
  • Ryo Sasaki; Hajime Matsumine; Yorikatsu Watanabe; Yuichi Takeuchi; Masayuki Yamato; Teruo Okano; Mariko Miyata; Tomohiro Ando
    PLASTIC AND RECONSTRUCTIVE SURGERY LIPPINCOTT WILLIAMS & WILKINS 134 (5) 970 - 978 0032-1052 2014/11 [Refereed]
     
    Background: Dental pulp tissue contains Schwann and neural progenitor cells. Tissue-engineered nerve conduits with dental pulp cells promote facial nerve regeneration in rats. However, no nerve functional or electrophysiologic evaluations were performed. This study investigated the compound muscle action potential recordings and facial functional analysis of dental pulp cell regenerated nerve in rats. Methods: A silicone tube containing rat dental pulp cells in type I collagen gel was transplanted into a 7-mm gap of the buccal branch of the facial nerve in Lewis rats; the same defect was created in the marginal mandibular branch, which was ligatured. Compound muscle action potential recordings of vibrissal muscles and facial functional analysis with facial palsy score of the nerve were performed. Results: Tubulation with dental pulp cells showed significantly lower facial palsy scores than the autograft group between 3 and 10 weeks postoperatively. However, the dental pulp cell facial palsy scores showed no significant difference from those of autograft after 11 weeks. Amplitude and duration of compound muscle action potentials in the dental pulp cell group showed no significant difference from those of the intact and autograft groups, and there was no significant difference in the latency of compound muscle action potentials between the groups at 13 weeks postoperatively. However, the latency in the dental pulp cell group was prolonged more than that of the intact group. Conclusion: Tubulation with dental pulp cells could recover facial nerve defects functionally and electrophysiologically, and the recovery became comparable to that of nerve autografting in rats.
  • Hajime Matsumine; Yuichi Takeuchi; Ryo Sasaki; Tomohiko Kazama; Koichiro Kano; Taro Matsumoto; Hiroyuki Sakurai; Mariko Miyata; Masayuki Yamato
    PLASTIC AND RECONSTRUCTIVE SURGERY LIPPINCOTT WILLIAMS & WILKINS 134 (4) 686 - 697 0032-1052 2014/10 [Refereed]
     
    Background: Dedifferentiated fat cells, obtained from the ex vivo ceiling culture of mature adipocytes of mammals, have a high proliferative potential and pluripotency. The authors transplanted dedifferentiated fat cells into a nerve defect created in rat facial nerve and evaluated nerve regeneration ability. Methods: The buccal branch of the facial nerve of rats was exposed, and a 7-mm nerve defect was created. Green fluorescent protein-positive dedifferentiated fat cells prepared from adipocytes were mixed with type 1 collagen scaffold and infused into a silicone tube, which was then transplanted into the nerve defect in a green fluorescent protein-negative rat (the dedifferentiated fat group). Regenerated nerves were excised at 13 weeks after transplantation and examined histologically and physiologically. The findings were compared with those of autografts and silicone tubes loaded with collagen gel alone (the control group) transplanted similarly. Results: Axon diameter of regenerated nerve increased significantly in the dedifferentiated fat group compared with the control group, whereas no significant difference was found between the dedifferentiated fat and autograft groups. Myelin thickness was found to be largest in the autograft group, followed by the dedifferentiated fat and the control groups, showing significant differences between all pairs of groups. Evaluation of physiologic function of nerves by compound muscle action potential revealed a significantly better result in the dedifferentiated fat group than in the control group. The regenerated nerves in the dedifferentiated fat group had S100 and green fluorescent protein-double-positive Schwann-like supportive cells. Conclusion: After being transplanted into a facial nerve defect, dedifferentiated fat cells promoted the maturation of the regenerated nerve.
  • Hajime Matsumine; Ryo Sasaki; Yuichi Takeuchi; Mariko Miyata; Masayuki Yamato; Teruo Okano; Hiroyuki Sakurai
    JOURNAL OF RECONSTRUCTIVE MICROSURGERY THIEME MEDICAL PUBL INC 30 (2) 127 - 136 0743-684X 2014/02 [Refereed]
     
    Histological and physiological basis of the therapeutic efficacy of the vascularized autologous nerve graft in facial nerve regeneration remains poorly understood because of no established rat model. The left median nerve and median artery/vein of Lewis rats were collectively ligated, and harvested as a vascularized island median nerve, which was transplanted to a 7-mm gap in the left buccal branch of facial nerve. Nerve regeneration was investigated. The numbers of myelinated fibers, axon diameter, and myelin thickness were significantly higher in the vascularized nerve graft group than in the nonvascularized nerve graft group. Compound muscle action potential measurement showed that the parameters of vascularized group were similar to those in the intact control group. A vascularized median nerve graft resulted in better facial nerve regeneration outcomes.
  • Yuichi Takeuchi; Hidetsugu Asano; Yoko Katayama; Yoshihiro Muragaki; Keiji Imoto; Mariko Miyata
    JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 34 (4) 1258 - 1270 0270-6474 2014/01 [Refereed]
     
    Functional synapse elimination and strengthening are crucial developmental processes in the formation of precise neuronal circuits in the somatosensory system, but the underlying alterations in topographical organization are not yet fully understood. To address this issue, we generated transgenic mice in which afferent fibers originating from the whisker-related brain region, called the maxillary principal trigeminal nucleus (PrV2), were selectively visualized with genetically expressed fluorescent protein. We found that functional synapse elimination drove and established large-scale somatotopic refinement even after the thalamic barreloid architecture was formed. Before functional synapse elimination, the whisker sensory thalamus was innervated by afferent fibers not only from the PrV2, but also from the brainstem nuclei representing other body parts. Most notably, only afferent fibers from PrV2 onto a whisker sensory thalamic neuron selectively survived and were strengthened, whereas other afferent fibers were preferentially eliminated via their functional synapse elimination. This large-scale somatotopic refinement was at least partially dependent on somatosensory experience. These novel results uncovered a previously unrecognized role of developmental synapse elimination in the large-scale, instead of the fine-scale, somatotopic refinement even after the initial segregation of the barreloid map.
  • Hajime Matsumine; Ryo Sasaki; Yuichi Takeuchi; Yorikatsu Watanabe; Yosuke Niimi; Hiroyuki Sakurai; Mariko Miyata; Masayuki Yamato
    Plastic and Reconstructive Surgery - Global Open Lippincott Williams and Wilkins 2 (10) e240  2169-7574 2014 [Refereed]
     
    Background: Extensive facial nerve defects between the facial nerve trunk and its branches can be clinically reconstructed by incorporating double innervation into an end-to-side loop graft technique. This study developed a new animal model to evaluate the technique's ability to promote nerve regeneration. Methods: Rats were divided into the intact, nonsupercharge, and supercharge groups. Artificially created facial nerve defects were reconstructed with a nerve graft, which was end-to-end sutured from proximal facial nerve stump to the mandibular branch (nonsupercharge group), or with the graft of which other end was end-to-side sutured to the hypoglossal nerve (supercharge group). And they were evaluated after 30 weeks. Results: Axonal diameter was significantly larger in the supercharge group than in the nonsupercharge group for the buccal (3.78 ± 1.68 vs 3.16 ± 1.22 P < 0.0001) and marginal mandibular branches (3.97 ± 2.31 vs 3.46 ± 1.57 P < 0.0001), but the diameter was significantly larger in the intact group for all branches except the temporal branch. In the supercharge group, compound muscle action potential amplitude was significantly higher than in the nonsupercharge group (4.18 ± 1.49 mV vs 1.87 ± 0.37 mV P < 0.0001) and similar to that in the intact group (4.11 ± 0.68 mV). Retrograde labeling showed that the mimetic muscles were double-innervated by facial and hypoglossal nerve nuclei in the supercharge group. Conclusions: Multiple facial nerve branch reconstruction with an endto-side loop graft was able to achieve axonal distribution. Additionally, axonal supercharge from the hypoglossal nerve significantly improved outcomes.
  • Yuichi Takeuchi; Miwako Yamasaki; Yasuyuki Nagumo; Keiji Imoto; Masahiko Watanabe; Mariko Miyata
    JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 32 (20) 6917 - 6930 0270-6474 2012/05 [Refereed]
     
    The remodeling of neural circuitry and changes in synaptic efficacy after peripheral sensory nerve injury are considered the basis for functional reorganization in the brain, including changes in receptive fields. However, when or how the remodeling occurs is largely unknown. Here we show the rapid rewiring of afferent fibers in the mature ventral posteromedial thalamic nucleus of mice after transection of the peripheral whisker sensory nerve, using the whole-cell voltage-clamp technique. Transection induced the recruitment of afferent fibers to a thalamic relay neuron within 5-6 d of injury. The rewiring was pathway specific, but not sensory experience dependent or peripheral nerve activity dependent. The newly recruited fibers mediated small EPSCs, and postsynaptic GluA2-containing AMPA receptors were selectively upregulated at the new synapses. This rapid and pathway-specific remodeling of thalamic circuitry may be an initial step in the massive axonal reorganization at supraspinal levels, which occurs months or years after peripheral sensory nerve injury.
  • Yasuyuki Nagumo; Yuichi Takeuchi; Keiji Imoto; Mariko Miyata
    NEUROSCIENCE RESEARCH ELSEVIER IRELAND LTD 69 (3) 203 - 213 0168-0102 2011/03 [Refereed]
     
    The rodent thalamic ventrobasal complex (VB) which is a subdivision of somatosensory thalamus receives two excitatory inputs through the medial lemniscal synapse, which is a sensory afferent synapse, and the corticothalamic synapse from layer VI of the somatosensory cortex. In addition, the VB also receives cholinergic inputs from the brain stem, and nicotinic acetylcholine receptors (nAChRs) are highly expressed in the VB. Little is known, however, how acetylcholine (ACh) modulates synaptic transmission at the medial lemniscal and corticothalamic synapses in the VB. Furthermore, it remains unclear which subtype of nAChRs contributes to VB synaptic transmission. We report here that the activation of nAChRs presynaptically depressed corticothalamic synaptic transmission, whereas it did not affect medial lemniscal synaptic transmission in juvenile mice. This presynaptic modulation was mediated by the activation of nAChRs that contained alpha 4 and beta 2 subunit, but not by alpha 7 nAChRs. Moreover, galanthamine, an allosteric modulator of alpha 4 beta 2 alpha 5 nAChR, enhanced the ACh-induced depression of corticothalamic excitatory postsynaptic currents (EPSCs), indicating that alpha 4 beta 2 alpha 5 nAChRs at corticothalamic axon terminals specifically contribute to the depression of corticothalamic synaptic transmission. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
  • Mitsuo Tanabe; Keiko Takasu; Yuichi Takeuchi; Hideki Ono
    JOURNAL OF NEUROSCIENCE RESEARCH WILEY-BLACKWELL 86 (15) 3258 - 3264 0360-4012 2008/11 [Refereed][Invited]
     
    The anti hypersensitivity actions of gabapentin and pregabalin have been well characterized in a large number of studies, although the underlying mechanisms have yet to be defined. We have been focusing on the supraspinal structure as a possible site for their action and have demonstrated that intracerebroventricular (i.c.v.) administration of gabapentin and pregabalin indeed decreases thermal and mechanical hypersensitivity in a murine chronic pain model involving partial ligation of the sciatic nerve. This novel supraspinally mediated analgesic effect was markedly suppressed by either depletion of central noradrenaline (NA) or blockade of spinal alpha(2)-adrenergic receptors. Moreover, i.c.v. injection of gabapentin and pregabalin increased spinal NA turnover in mice only after peripheral nerve injury. In locus coeruleus (LC) neurons in brainstem slices prepared from mice after peripheral nerve injury, gabapentin reduced the gamma-aminobutyric acid (GABA) type A receptor-mediated inhibitory postsynaptic currents (IPSCs). Glutamate-mediated excitatory synaptic transmission was hardly affected. Moreover, gabapentin did not reduce IPSCs in slices taken from mice given a sham operation. Although gabapentin altered neither the amplitude nor the frequency of miniature IPSCs, it reduced IPSCs together with an increase in the paired-pulse ratio, suggesting that gabapentin acts on the presynaptic GABAergic nerve terminals in the LC. Together, the data suggest that gabapentin presynaptically reduces GABAergic synaptic transmission, thereby removing the inhibitory influence on LC neurons only in neuropathic pain states, leading to activation of the descending noradrenergic system. (C) 2008 Wiley-Liss, Inc.
  • Yuichi Takeuchi; Keiko Takasu; Hideki Ono; Mitsuo Tanabe
    NEUROPHARMACOLOGY PERGAMON-ELSEVIER SCIENCE LTD 53 (7) 842 - 853 0028-3908 2007/12 [Refereed]
     
    We have previously demonstrated that gabapentin supraspinally activates the descending noradrenergic system to alleviate neuropathic pain. In this study, we investigated whether pregabalin, an antiepileptic and analgesic drug that is also designed as a structural analogue of gamma-aminobutyric acid (GABA), exhibits supraspinal analgesic effects similar to those of gabapentin involving the descending noradrenergic system. Both systemically (intraperitoneally; i.p.) and locally (intracerebroventricularly or intrathecally; i.c.v. or i.t.) injected pregabalin reduced thermal and mechanical hypersensitivity in a murine chronic pain model that was prepared by partial ligation of the sciatic nerve (the Seltzer model), suggesting that pregabalin acts at both supraspinal and spinal loci. The supraspinal analgesic action of pregabalin was observed only after peripheral nerve injury. and pregabalin (i.p. and i.c.v.) did not affect acute thermal and mechanical nociception, Depletion of spinal noradrenaline (NA) or pharmacological blockade of spinal alpha(2)-adrenoceptors with yohimbine i.p. or i.t.), but not alpha(1)-adrenoceptors with prazosin (i.p.), reduced the analgesic effects of pregabalin (i.p. or i.c.v.) on thermal and mechanical hypersensitivity. Moreover. i,c.v.-administered pregabalin dose-dependently increased the spinal 4-hydroxy-3-methoxyphenylglycol (MHPG) content and the MHPG/NA ratio only in mice with neuropathic pain, whereas the concentrations of NA, serotonin, 5-hydroxyindoleacetic acid and dopamine were unchanged, demonstrating that supraspinal pregabalin accelerated the spinal turnover of NA. Together, these results indicate that pregabalin Supraspinally activates the descending noradrenergic pain inhibitory system coupled with spinal alpha(2)-adrenoceptors to ameliorate neuropathic pain. (c) 2007 Elsevier Ltd. All rights reserved.
  • Mitsuo Tanabe; Yuichi Takeuchi; Hideki Ono
    JOURNAL OF PHARMACOLOGICAL SCIENCES JAPANESE PHARMACOLOGICAL SOC 104 (4) 335 - 340 1347-8613 2007/08 [Refereed]
     
    We have previously demonstrated that the antiepileptic drug zonisamide supraspinally generates analgesic effects on thermal and mechanical hypersensitivity in mice after peripheral nerve injury. To further establish the neurochemical basis for the supraspinally mediated analgesic action of zonisamide, we measured spinal noradrenaline (NA), 3-methoxy-4hydroxyphenyleneglycol (MHPG), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and dopamine (DA) contents using HPLC with electrochemical detection in a murine neuropathic pain model that was prepared by partial ligation of the sciatic nerve (Seltzer model). Intraperitoneally or intracerebroventricularly administered zonisamide (50 mg/kg, i.p. and 30 mu g, i.c.v., respectively), which almost completely reduced mechanical hypersensitivity, did not elicit any changes in spinal NA, MHPG, 5-HT, 5-HIAA, and DA contents. Moreover, the effectiveness of i.p. or i.c.v. administered zonisamide at reducing thermal and mechanical hypersensitivity was not influenced by intrathecally administered yohimbine (3,mu g), an alpha(2)-adrenergic receptor antagonist. Thus, it appears that the supraspinally mediated analgesic effects of zonisamide are independent of the descending monoaminergic pain inhibitory system.
  • Yuichi Takeuchi; Keiko Takasu; Motoko Honda; Hideki Ono; Mitsuo Tanabe
    EUROPEAN JOURNAL OF PHARMACOLOGY ELSEVIER SCIENCE BV 556 (1-3) 69 - 74 0014-2999 2007/02 [Refereed]
     
    We have previously demonstrated that gabapentin supraspinally activates the descending noradrenergic system to produce analgesic effects after peripheral nerve injury. To further establish the neurochemical basis for its supraspinally mediated analgesic action, concentrations of spinal noradrenaline, 4-hydroxy-3-methoxyphenylglycol (MHPG), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and dopamine were measured using high-performance liquid chromatography in a murine neuropathic pain model that was prepared by partial ligation of the sciatic nerve (the Seltzer model). Intracerebroventricularly (i.c.v.) administered gabapentin (100 and 300 mu g) increased the spinal MHPG concentration and the MHPG/noradrenaline ratio and alleviated mechanical hypersensitivity, whereas the concentrations of noradrenaline, 5-HT, 5-HIAA and dopamine were unchanged. By contrast, i.c.v. gabapentin neither affected the spinal MHPG concentration and MHPG/noradrenaline ratio nor exhibited analgesic effects in animals subjected to a sham operation. In addition, spinal monoamine levels in ligated animals were not changed after intrathecal administration of gabapentin which however generated analgesic effects. Thus, the supraspinally mediated analgesic effects of gabapentin are correlated with an increase in spinal noradrenaline turnover. (c) 2006 Elsevier B.V. All rights reserved.

Books etc

  • 原巧樹; 竹内雄一 (Contributor報酬系脳領域刺激による脳疾患治療)北隆館 2023/03 63 52-54
  • Takeuchi Y; Kawano T; Li Q; Mima T; Nagai J (Editor)Lausanne: Frontiers Media SA 2022/06 9782889764587
  • 竹内雄一; 関和彦 (Contributor超音波ニューロモデュレーション)中外医学社 2022/02 249-253
  • Yuichi Takeuchi (Contributorオシレーション治療)Chugai-igakusha 2021/07 847–851
  • Takeuchi Y (ContributorToward real-time control of neuropsychiatric disorders)Hokuryukan. 2021/01 68 67–59
  • Takeuchi Y (ContributorDevelopment of on-demand interventions of epileptic seizures and a quantitative method of seizure susceptibility)Hokuryukan 2020/08
  • Takeuchi Y (ContributorRevealing neuronal network dynamics underlying behavioral phenotypes of psychiatric disorders, Medical Science Digest 46 (6): 906-909, 2020.)Hokuryukan 2020/06 906-909 
    Medical Science Digest 46 (6): 906-909, 2020.
  • Epilepsy progress
    Yuichi Takeuchi (ContributorDevelopment of on-demand interventions of epileptic seizures and a quantitative method of seizure susceptibility)Hokuryukan 2020/01 60 118-121 
    Medical Science Digest 46 (2): 118-121
  • Neurophysiology of body image
    Miyata M; Takeuchi Y (ContributorRemodeling of the body map)Chugai-Igakusha 2011/08 895-899 
    Clin Neurosci 29 (8): 895-899.

Conference Activities & Talks

Works

  • Takeuchi Y Software 2020/05 - Today
  • Takeuchi Y Others 2020/05 
    A solenoid valve driver
  • Takeuchi Y Others 2020/05 
    A PCB board for small EIB pins
  • Takeuchi Y Others 2020/05 
    A foot shock device based on the design of Fred A. Masterson
  • Yuichi Takeuchi Others 2018/04 
    Motion detector with three infrared LED and phototransistor pairs
  • Yuichi Takeuchi Others 2018/04 
    On-head Faraday cage for electrophysiological experiments with freely-moving rats
  • Yuichi Takeuchi Others 2018/04 
    Dimensions of head holder, arms, and restraint frames for headfix behavioral experiments with mice
  • Yuichi Takeuchi Others 2018/04 
    Dimensions of head holder, arms, and restraint frames for headfix behavioral experiments with rats
  • Yuichi Takeuchi Software 2018/04 
    C++ codes for auditory cue presentations and reward deliveries with STM microcomputers
  • Yuichi Takeuchi Others figshare 2018/04 
    A microcomputer-based system for task control of animal experiments
  • Yuichi Takeuchi Software 2018/04 
    Collection of g files for an SM-2 conductance injection system
  • Yuichi Takeuchi Others figshare 2018/03 
    Protocols for retrograde labelings of motor neurons from peripheral tissues of rodents
  • Yuichi Takeuchi Others Mendeley Data 2018/03 
    An online method package for method of compound-muscle action potential recordings from rodent vibrissal muscles
  • Yuichi Takeuchi Software 2018/03 
    Matlab codes for neuronal membrane potential analyses
  • Yuichi Takeuchi Database 2017/11 
    Neuromorpho.org
  • Yuichi Takeuchi Database 2017/11 
    Neuromorpho.org
  • Yuichi Takeuchi Others figshare 2017/09 
    Microcomputer-based negative-feedback circuit
  • Yuichi Takeuchi Others 2017/09 
    Active bandpass filter with four times amplification
  • Yuichi Takeuchi Others 2017/09 
    A foot shock electrical circuit for fear memory researches
  • Yuichi Takeuchi Software 2017/09 
    Matlab code for auditory cue-dependent fear conditioning.
  • Yuichi Takeuchi Software 2017/09 
    C++ code and electronics for feedback voltage control with a microcomputer
  • Yuichi Takeuchi Software 2017/06 
    Practical R script collection for biostatistics.
  • Yuichi Takeuchi Software 2017/06 
    Matlab GUI for automatic action potential detection of membrane potential recordings.
  • Yuichi Takeuchi Software 2017/06 
    Matlab GUI for controlling NI data acquisition boards.
  • Yuichi Takeuchi Software 2017/06 
    Igor Pro GUI for a versatile data acquisition environment with an InstruTECH ITC18.
  • Yuichi Takeuchi Software 2017/06 
    Igor Pro GUI for a versatile data acquisition environment with an InstruTECH ITC16.
  • Yuichi Takeuchi Software 2017/06 
    Igor Pro GUI for importing any neurophysiology data in neuroshare format.
  • Yuichi Takeuchi Software 2017/06 
    Igor Pro GUI which offers a spike sorting environment for extracellular recordings.
  • Yuichi Takeuchi Software 2017/06 
    Igor Pro GUI which offers an analytical environment for miniature events.
  • Yuichi Takeuchi Software 2017/06 
    Igor Pro GUI which offers a general purpose analytical environment.
  • Yuichi Takeuchi Software 2017/05 
    Igor Pro GUI used for averaging, analyses, and figure preparation of evoked potentials.
  • Yuichi Takeuchi Software Szeged 2017/05 
    Matlab GUI which randomly asks 3 questions and normal values on medical physiolgy.

MISC

Awards & Honors

  • 2024/03 The Physiogicial Society of Japan Promotion Award of the Physiological Society Japan for Young Scientists
     神経・精神疾患の制御を目的とした新規脳刺激技術の研究開発 
    受賞者: Yuichi Takeuchi
  • 2023/10 Hokkaido University Cross-Departmental Symposium Research Encouraging Award
     
    受賞者: Yuichi Takeuchi
  • 2022/10 Hokkaido University Cross-Departmental Symposium Research Encouragement Award
     
    受賞者: Yuichi Takeuchi
  • 2022/06 Nishinomiya Basic Research Fund Research award
     
    受賞者: Yuichi Takeuchi
  • 2019/03 Young Researchers' Society of Neurobehavioral Pharmacology Special Award
     
    受賞者: Yuichi Takeuchi
  • 2013/08 Physiological Society of Japan Incentive Award for Young Scientist
     japan_society 
    受賞者: Yuichi Takeuchi
  • 2012/09 Narishige Neuroscience Research Foundation Research Award
     
    受賞者: Yuichi Takeuchi

Research Grants & Projects

Teaching Experience

  • Advanced Lecture on Pharmaceutical and Biological ScienceAdvanced Lecture on Pharmaceutical and Biological Science Kindai University
  • Advanced Lecture on Pharmaceutical and Biological ScienceAdvanced Lecture on Pharmaceutical and Biological Science Kindai University
  • Laboratory DiagnosisLaboratory Diagnosis Kindai University
  • Laboratory Exam and Therapy of Diseases 2Laboratory Exam and Therapy of Diseases 2 Kindai University
  • Pharmacotherapy 2Pharmacotherapy 2 Kindai University
  • Kindai SeminarKindai Seminar Kindai University
  • General Seminar 2General Seminar 2 Kindai University
  • Laboratory Exam and Therapy of Diseases 1Laboratory Exam and Therapy of Diseases 1 Kindai University
  • Laboratory Course of Pharmacology and PharmacokineticsLaboratory Course of Pharmacology and Pharmacokinetics Kindai University
  • Introduction to PharmacyIntroduction to Pharmacy Kindai University
  • Genral Seminar 1Genral Seminar 1 Kindai University
  • Pharmacotherapy 3Pharmacotherapy 3 Kindai University
  • Pharmacotherapy 1Pharmacotherapy 1 Kindai University
  • PathologyPathology Kindai University
  • Introduction of Brain Researches in Hokkaido UniversityIntroduction of Brain Researches in Hokkaido University Hokkaido University
  • A Guide to Neuroscience ResearchesA Guide to Neuroscience Researches Hokkaido University
  • Introduction to Pharmaceutical ScienceIntroduction to Pharmaceutical Science Hokkaido University
  • Brain Science I (Practice)Brain Science I (Practice) Hokkaido University
  • Freshman Seminar: Introduction of NeuropharmacologyFreshman Seminar: Introduction of Neuropharmacology Hokkaido University
  • Brain Science I (Lecture)Brain Science I (Lecture) Hokkaido University
  • Pharmacology IIIPharmacology III Hokkaido University
  • Pharmacology IIPharmacology II Hokkaido University
  • Methods in Life Science IIMethods in Life Science II Hokkaido University
  • Laboratory Exercise of Analytical ChemistryLaboratory Exercise of Analytical Chemistry Hokkaido University
  • Pharmacology IVPharmacology IV Hokkaido University
  • Basic Brain Science IVBasic Brain Science IV Hokkaido University
  • Pharmaceutical SciencePharmaceutical Science Hokkaido University
  • Training Course for Electrophysiology: Hokkaido Summer Institute Hokkaido University
  • Medical PharmacologyMedical Pharmacology Hungarian Medical Universities
  • Medical PhysiologyMedical Physiology University of Szeged
  • Internship abroad programsInternship abroad programs Toyohashi University of Technology
  • Respiratory MedicineRespiratory Medicine Tokyo Women's Medical University
  • PBL, TBL TutorialsPBL, TBL Tutorials Tokyo Women's Medical University
  • Physiology practicePhysiology practice Tokyo Women's Medical University
  • NIPS Training CourseNIPS Training Course National Institute for Physiological Sciences

Committee Membership

  • 2023/11 - Today   International Union of Physiological Sciences   International Mentoring Program Mentor
  • 2023/05 - Today   Frontiers in Behavioral Neuroscience   Review Editor
  • 2021/03 - Today   Japanese Pharmacological Society   Board member
  • 2020/11 - Today   Fronteirs in Human Neuroscience   Guest Associate Editor
  • 2020/03 - Today   The Physiological Society of Japan   Board member
  • 2022/04 -2024/03   The Pharmaceutical Society of Japan Hokkaido Branch   Board Member
  • 2020/11 -2021/12   Frontiers in Behavioral Neuroscience   Guest Associate Editor

Social Contribution

  • Date (from-to) : 2023/09/11-Today
    Role : Informant
    Category : Internet
    Sponser, Organizer, Publisher  : The Japan Neuroscience Society
  • AMED Prime application
    Date (from-to) : 2023/04/26
    Role : Lecturer
    Category : Lecture
    Sponser, Organizer, Publisher  : Hokkaido University
    Event, Program, Title : AMED CREST Prime application
  • Open lab
    Date (from-to) : 2022/08/07-2022/08/08
    Role : Organizing member
    Category : Open college
    Sponser, Organizer, Publisher  : Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
  • Date (from-to) : 2021/12/24
    Role : Editor
    Category : Paper
    Sponser, Organizer, Publisher  : Frontiers
  • Date (from-to) : 2021/11/25
    Role : Editor
    Category : Paper
    Sponser, Organizer, Publisher  : Frontiers
  • Date (from-to) : 2021/07/19
    Role : Editor
    Category : Paper
    Sponser, Organizer, Publisher  : Frontiers
  • Date (from-to) : 2021/06/23
    Role : Editor
    Category : Paper
    Sponser, Organizer, Publisher  : Frontiers
  • Date (from-to) : 2021/05/14
    Role : Editor
    Category : Paper
    Sponser, Organizer, Publisher  : Frontiers
    Researchers
  • Date (from-to) : 2021/05/14
    Role : Editor
    Category : Paper
    Sponser, Organizer, Publisher  : Frontiers
    Researchers
  • Date (from-to) : 2017/03-2017/03
    Role : Coverage cooperation
    Category : Internet
    Sponser, Organizer, Publisher  : 私立大学医学部に入ろう.com
    Event, Program, Title : 海外医学部 医学部情報
  • Open lab
    Date (from-to) : 2016/11/26-2016/11/26
    Role : Organizing member
    Category : Open college
    Sponser, Organizer, Publisher  : Department of Physiology, University of Szeged, Hungary
  • Open lab
    Date (from-to) : 2014/09/20-2014/09/20
    Role : Organizing member
    Category : Open college
    Sponser, Organizer, Publisher  : School of Medicine, Tokyo Women’s Medical University
  • Open lab
    Date (from-to) : 2008/11/01-2008/11/01
    Role : Organizing member
    Category : Open college
    Sponser, Organizer, Publisher  : National Institute of Physiological Sciences

Academic Contribution

  • Date (from-to) :2023/02/07-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Bentham Science Publishers
  • Date (from-to) :2022/12/10-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Bentham Science Publishers
  • Date (from-to) :2022/07/24-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Springer Nature
  • Frontiers in Neural Circuits
    Date (from-to) :2022/06/14-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Frontiers
  • Date (from-to) :2022/05/06-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Taylor & Francis
  • Neurology and Clinical Neuroscience
    Date (from-to) :2022/01/18-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Wiley
  • Date (from-to) :2021/11/19-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Frontiers in Human Neuroscience
  • Date (from-to) :2021/02/27-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: De Gruyter
  • Date (from-to) :2020/11/09-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: AME Publishing Company
  • Date (from-to) :2019/09/28-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Wiley
  • Date (from-to) :2018/07/01-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Gavin Publishers
  • Date (from-to) :2017/12/10-Today
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: Elsevier
  • Date (from-to) :2024/03/28-2024/03/28
    Role: Planning etc
    Type: Competition etc
    Organizer, responsible person: The 101st Annual Meeting of The Physiological Society of Japan
    Kita-Kyushu
  • Special seminar
    Date (from-to) :2024/03/14-2024/03/14
    Role: Planning etc
    Type: Academic society etc
    Organizer, responsible person: The Pharmaceutical Society of Japan Hokkaido Branch
  • Special seminar
    Date (from-to) :2024/02/21-2024/02/24
    Role: Planning etc
    Type: Academic society etc
    Organizer, responsible person: The Pharmaceutical Society of Japan Hokkaido Branch
  • Young Researchers' Symposium
    Date (from-to) :2023/10/18-2023/10/18
    Role: Planning etc
    Type: Academic society etc
    Organizer, responsible person: The Pharmaceutical Society of Japan Hokkaido Branch
  • Date (from-to) :2023/08/04
    Role: Panel chair etc
    Type: Competition etc
    Organizer, responsible person: The 46th Annual Meeting of the Japan Neuroscience Society
    Sendai
  • Oral Session
    Date (from-to) :2023/05/20-2023/05/20
    Role: Panel chair etc
    Type: Academic society etc
    Organizer, responsible person: The 150th Annual Meeting of the Pharmaceutical Society of Japan Hokkaido branch
  • Date (from-to) :2022/06/30
    Role: Panel chair etc
    Type: Competition etc
    Organizer, responsible person: Neuro2022
    沖縄
  • Date (from-to) :2020/11/24-2021/12/31
    Role: Planning etc
    Type: Review
    Organizer, responsible person: Frontiers
  • Date (from-to) :2021/12/30
    Role: Peer review
    Type: Peer review etc
    Organizer, responsible person: UKRI – UK Research and Innovation
  • Date (from-to) :2021/08/26
    Role: Panel chair etc
    Type: Competition etc
    Organizer, responsible person: 生体機能と創薬シンポジウム2021
    札幌
  • Date (from-to) :2020/07/29
    Role: Planning etc
    Type: Competition etc
    Organizer, responsible person: The 43rd Annual Meeting of the Japan Neuroscience Society
  • Date (from-to) :2019/03/31
    Role: Panel chair etc
    Type: Competition etc
    Organizer, responsible person: FAOPS
  • Date (from-to) :2018/07/14
    Role: Panel chair etc
    Type: Academic society etc
    Organizer, responsible person: PCS

Others

  • 2021/11 - Today  Pharmacology Educator 
    The Japanese Pharmacological Society, No. 0539
  • 2020/05 - Today  Curriculum Vitae 
    https://github.com/yuichi-takeuchi/curriculum_vitae
  • 2018/01 - Today  Certified Publons academy peer reviewer 
    Graduates of the Publons Academy practical Peer Review course have been endorsed by a qualified mentor after completing peer review course work corresponding to 10-15 hours.
  • 2017/01 - Today  Certificate - "FELASA C" Course 
    Certificate of successful completion of 80-hr course on "Animal experiments theory and practice". The course has been certificated by the Federation of European Laboratory Animal Science Associations (FELASA), and it is accordance with the recommendations of FELASA on the education and training of persons working with laboratory animals (FELASA category C). The course was organized and coordinated by the institute of Surgical Research, University of Szeged, Hungary.
  • 2016/01 - Today  Physiology educator 
    Physiological Society of Japan, No. 160018
  • 2005/11 - Today  Japanese pharmacist license 
    No. 399397

Other link

researchmap


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